

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit assembly (GO:0000028) | 6.12131198 |
| 2 | viral transcription (GO:0019083) | 6.03226167 |
| 3 | translational termination (GO:0006415) | 5.85159793 |
| 4 | ribosomal small subunit biogenesis (GO:0042274) | 5.82766408 |
| 5 | DNA deamination (GO:0045006) | 5.50124833 |
| 6 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 5.37909172 |
| 7 | respiratory electron transport chain (GO:0022904) | 5.34548929 |
| 8 | maturation of SSU-rRNA (GO:0030490) | 5.28943672 |
| 9 | electron transport chain (GO:0022900) | 5.23890590 |
| 10 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 5.16901316 |
| 11 | protein complex biogenesis (GO:0070271) | 5.12289999 |
| 12 | translational elongation (GO:0006414) | 5.11067477 |
| 13 | cotranslational protein targeting to membrane (GO:0006613) | 5.09452673 |
| 14 | protein targeting to ER (GO:0045047) | 5.05577219 |
| 15 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.84371708 |
| 16 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.79339126 |
| 17 | protein localization to endoplasmic reticulum (GO:0070972) | 4.77386017 |
| 18 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.77190893 |
| 19 | NADH dehydrogenase complex assembly (GO:0010257) | 4.77190893 |
| 20 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.77190893 |
| 21 | translational initiation (GO:0006413) | 4.75324829 |
| 22 | ribosomal large subunit biogenesis (GO:0042273) | 4.71791030 |
| 23 | viral life cycle (GO:0019058) | 4.64343368 |
| 24 | cellular protein complex disassembly (GO:0043624) | 4.62326627 |
| 25 | proteasome assembly (GO:0043248) | 4.56525954 |
| 26 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.55021999 |
| 27 | regulation of mitochondrial translation (GO:0070129) | 4.43617203 |
| 28 | respiratory chain complex IV assembly (GO:0008535) | 4.31290470 |
| 29 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.27181187 |
| 30 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.26146549 |
| 31 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.25907165 |
| 32 | termination of RNA polymerase III transcription (GO:0006386) | 4.25907165 |
| 33 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 4.23936453 |
| 34 | formation of translation preinitiation complex (GO:0001731) | 4.20600339 |
| 35 | oxidative phosphorylation (GO:0006119) | 4.19717588 |
| 36 | translation (GO:0006412) | 4.16669618 |
| 37 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.16286790 |
| 38 | cytochrome complex assembly (GO:0017004) | 4.07366722 |
| 39 | DNA strand elongation (GO:0022616) | 4.06325644 |
| 40 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.04008110 |
| 41 | protein complex disassembly (GO:0043241) | 4.02664825 |
| 42 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.01272228 |
| 43 | establishment of integrated proviral latency (GO:0075713) | 3.82960319 |
| 44 | macromolecular complex disassembly (GO:0032984) | 3.82648111 |
| 45 | ATP synthesis coupled proton transport (GO:0015986) | 3.82197122 |
| 46 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.82197122 |
| 47 | DNA replication initiation (GO:0006270) | 3.80870504 |
| 48 | protein localization to mitochondrion (GO:0070585) | 3.78259974 |
| 49 | ATP biosynthetic process (GO:0006754) | 3.77199445 |
| 50 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.75070240 |
| 51 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.72894356 |
| 52 | spliceosomal snRNP assembly (GO:0000387) | 3.72534165 |
| 53 | rRNA processing (GO:0006364) | 3.72138842 |
| 54 | negative regulation of ligase activity (GO:0051352) | 3.71555351 |
| 55 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.71555351 |
| 56 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.71543248 |
| 57 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.69468942 |
| 58 | telomere maintenance via recombination (GO:0000722) | 3.68825795 |
| 59 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.68803587 |
| 60 | protein neddylation (GO:0045116) | 3.59016156 |
| 61 | 7-methylguanosine mRNA capping (GO:0006370) | 3.58626064 |
| 62 | rRNA metabolic process (GO:0016072) | 3.57950371 |
| 63 | 7-methylguanosine RNA capping (GO:0009452) | 3.57165120 |
| 64 | RNA capping (GO:0036260) | 3.57165120 |
| 65 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.56519544 |
| 66 | pseudouridine synthesis (GO:0001522) | 3.55471903 |
| 67 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.52599743 |
| 68 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.52525851 |
| 69 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.51686657 |
| 70 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.51686657 |
| 71 | rRNA modification (GO:0000154) | 3.50962349 |
| 72 | cellular component biogenesis (GO:0044085) | 3.50221547 |
| 73 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.49368090 |
| 74 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.49368090 |
| 75 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.49368090 |
| 76 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.48601174 |
| 77 | DNA replication checkpoint (GO:0000076) | 3.47683192 |
| 78 | CENP-A containing nucleosome assembly (GO:0034080) | 3.44740241 |
| 79 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.43735894 |
| 80 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.42188191 |
| 81 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 3.40675518 |
| 82 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.40552631 |
| 83 | hydrogen ion transmembrane transport (GO:1902600) | 3.40523434 |
| 84 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.39896787 |
| 85 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.39896787 |
| 86 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.39208895 |
| 87 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.38651151 |
| 88 | inner mitochondrial membrane organization (GO:0007007) | 3.37486657 |
| 89 | mRNA catabolic process (GO:0006402) | 3.35867226 |
| 90 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.35238868 |
| 91 | nucleobase biosynthetic process (GO:0046112) | 3.33837142 |
| 92 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.33461325 |
| 93 | mitochondrial transport (GO:0006839) | 3.33457531 |
| 94 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.33187898 |
| 95 | chromatin remodeling at centromere (GO:0031055) | 3.33185215 |
| 96 | deoxyribonucleotide catabolic process (GO:0009264) | 3.33032265 |
| 97 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.32840593 |
| 98 | telomere maintenance via telomere lengthening (GO:0010833) | 3.32247390 |
| 99 | ribosome biogenesis (GO:0042254) | 3.31958301 |
| 100 | mitotic recombination (GO:0006312) | 3.31591929 |
| 101 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.27539263 |
| 102 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.27539263 |
| 103 | protein targeting to membrane (GO:0006612) | 3.26516686 |
| 104 | aerobic respiration (GO:0009060) | 3.25859440 |
| 105 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.24848667 |
| 106 | spliceosomal complex assembly (GO:0000245) | 3.24775920 |
| 107 | GTP biosynthetic process (GO:0006183) | 3.22876135 |
| 108 | peptidyl-histidine modification (GO:0018202) | 3.22113641 |
| 109 | RNA catabolic process (GO:0006401) | 3.20963261 |
| 110 | deoxyribose phosphate catabolic process (GO:0046386) | 3.20539561 |
| 111 | viral mRNA export from host cell nucleus (GO:0046784) | 3.17693636 |
| 112 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.16276507 |
| 113 | establishment of viral latency (GO:0019043) | 3.15654459 |
| 114 | protein localization to kinetochore (GO:0034501) | 3.15197992 |
| 115 | positive regulation of ligase activity (GO:0051351) | 3.13809838 |
| 116 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.13182255 |
| 117 | mitotic metaphase plate congression (GO:0007080) | 3.12466234 |
| 118 | nucleoside triphosphate biosynthetic process (GO:0009142) | 3.12278451 |
| 119 | purine nucleobase biosynthetic process (GO:0009113) | 3.11630485 |
| 120 | UTP biosynthetic process (GO:0006228) | 3.11388919 |
| 121 | transcription from RNA polymerase I promoter (GO:0006360) | 3.10638832 |
| 122 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.10171473 |
| 123 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 3.09420866 |
| 124 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.09172264 |
| 125 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.08614194 |
| 126 | establishment of protein localization to mitochondrion (GO:0072655) | 3.08059757 |
| 127 | protein targeting to mitochondrion (GO:0006626) | 3.07210381 |
| 128 | termination of RNA polymerase I transcription (GO:0006363) | 3.06956201 |
| 129 | protein maturation by protein folding (GO:0022417) | 3.05926411 |
| 130 | kinetochore assembly (GO:0051382) | 3.05079457 |
| 131 | purine nucleoside monophosphate biosynthetic process (GO:0009127) | 3.03989023 |
| 132 | purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 3.03989023 |
| 133 | cell cycle G1/S phase transition (GO:0044843) | 2.99989446 |
| 134 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.99989446 |
| 135 | chaperone-mediated protein transport (GO:0072321) | 2.97251002 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.69377126 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.45113979 |
| 3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.13020811 |
| 4 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.93942334 |
| 5 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.83555717 |
| 6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.79251242 |
| 7 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.65545181 |
| 8 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.51721398 |
| 9 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.50837506 |
| 10 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.20351792 |
| 11 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.20176625 |
| 12 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.18439612 |
| 13 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.06158904 |
| 14 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.00729156 |
| 15 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.93154681 |
| 16 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.88147784 |
| 17 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.82075025 |
| 18 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.66742120 |
| 19 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.59127994 |
| 20 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.56001025 |
| 21 | * XRN2_22483619_ChIP-Seq_HELA_Human | 2.55990588 |
| 22 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.55926743 |
| 23 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.45154242 |
| 24 | * ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.39244047 |
| 25 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.37562102 |
| 26 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.29745090 |
| 27 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.26255679 |
| 28 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.24449106 |
| 29 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.19531227 |
| 30 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.12952209 |
| 31 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.09952409 |
| 32 | * TTF2_22483619_ChIP-Seq_HELA_Human | 2.07166263 |
| 33 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.05008747 |
| 34 | * SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.01207782 |
| 35 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.97495389 |
| 36 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.86663632 |
| 37 | * ELK1_19687146_ChIP-ChIP_HELA_Human | 1.82850735 |
| 38 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.80561653 |
| 39 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.76358073 |
| 40 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.74904000 |
| 41 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.73401689 |
| 42 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.73196773 |
| 43 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.71377661 |
| 44 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.64938565 |
| 45 | * HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.64405794 |
| 46 | * CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.63581699 |
| 47 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.62085028 |
| 48 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.60871317 |
| 49 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.59225477 |
| 50 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.56836355 |
| 51 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.50676843 |
| 52 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.49646650 |
| 53 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.47228675 |
| 54 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.45029581 |
| 55 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.42509229 |
| 56 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.39318334 |
| 57 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.38249937 |
| 58 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.37489738 |
| 59 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.35813748 |
| 60 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.35151380 |
| 61 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.34909632 |
| 62 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.32242131 |
| 63 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.31624801 |
| 64 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.30742173 |
| 65 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.24089437 |
| 66 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.23024254 |
| 67 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.22214051 |
| 68 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.19961163 |
| 69 | * MYC_18940864_ChIP-ChIP_HL60_Human | 1.18371413 |
| 70 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.16588807 |
| 71 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.12262730 |
| 72 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.09787818 |
| 73 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.08330980 |
| 74 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.07518427 |
| 75 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.07291854 |
| 76 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.06464959 |
| 77 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.05139867 |
| 78 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.03585672 |
| 79 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.02733880 |
| 80 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.01580305 |
| 81 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.00768549 |
| 82 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.00581822 |
| 83 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.00230196 |
| 84 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.99823366 |
| 85 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.99149179 |
| 86 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.98993518 |
| 87 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.97846552 |
| 88 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.96172174 |
| 89 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.96026242 |
| 90 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.95465695 |
| 91 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.94919385 |
| 92 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.94814207 |
| 93 | * GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.94474923 |
| 94 | * PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.92961140 |
| 95 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.92616732 |
| 96 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.92593988 |
| 97 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.90928317 |
| 98 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.88458999 |
| 99 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.88283276 |
| 100 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.87124042 |
| 101 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.87050422 |
| 102 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.86594718 |
| 103 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.86242338 |
| 104 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.86239730 |
| 105 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.84436994 |
| 106 | * OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.83337615 |
| 107 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.80850074 |
| 108 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.80571496 |
| 109 | * SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.79963220 |
| 110 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.76460787 |
| 111 | MYC_22102868_ChIP-Seq_BL_Human | 0.76071739 |
| 112 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.75785532 |
| 113 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 0.75371469 |
| 114 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.75100657 |
| 115 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.72757615 |
| 116 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.72079026 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.69599777 |
| 2 | MP0004957_abnormal_blastocyst_morpholog | 4.31951157 |
| 3 | MP0003111_abnormal_nucleus_morphology | 3.81077116 |
| 4 | MP0010094_abnormal_chromosome_stability | 3.74011890 |
| 5 | MP0003077_abnormal_cell_cycle | 3.62729481 |
| 6 | MP0008057_abnormal_DNA_replication | 3.62480661 |
| 7 | MP0009379_abnormal_foot_pigmentation | 3.36075568 |
| 8 | MP0008058_abnormal_DNA_repair | 3.18643546 |
| 9 | MP0008932_abnormal_embryonic_tissue | 2.85596937 |
| 10 | MP0008007_abnormal_cellular_replicative | 2.63349225 |
| 11 | MP0003786_premature_aging | 2.26776236 |
| 12 | MP0003718_maternal_effect | 2.16053377 |
| 13 | MP0009333_abnormal_splenocyte_physiolog | 2.03035389 |
| 14 | MP0002396_abnormal_hematopoietic_system | 2.01201422 |
| 15 | MP0003186_abnormal_redox_activity | 1.97280550 |
| 16 | MP0002132_abnormal_respiratory_system | 1.96814252 |
| 17 | MP0000490_abnormal_crypts_of | 1.88057063 |
| 18 | MP0001764_abnormal_homeostasis | 1.87671670 |
| 19 | MP0003136_yellow_coat_color | 1.85603481 |
| 20 | MP0008789_abnormal_olfactory_epithelium | 1.72435725 |
| 21 | MP0002837_dystrophic_cardiac_calcinosis | 1.71555496 |
| 22 | MP0006292_abnormal_olfactory_placode | 1.71010587 |
| 23 | MP0003806_abnormal_nucleotide_metabolis | 1.70377606 |
| 24 | MP0003315_abnormal_perineum_morphology | 1.66914958 |
| 25 | MP0005379_endocrine/exocrine_gland_phen | 1.61876318 |
| 26 | MP0001730_embryonic_growth_arrest | 1.60424916 |
| 27 | MP0005084_abnormal_gallbladder_morpholo | 1.58549232 |
| 28 | MP0000350_abnormal_cell_proliferation | 1.58384675 |
| 29 | MP0004133_heterotaxia | 1.54442852 |
| 30 | MP0001529_abnormal_vocalization | 1.51072155 |
| 31 | MP0008877_abnormal_DNA_methylation | 1.48904563 |
| 32 | MP0003123_paternal_imprinting | 1.45696173 |
| 33 | MP0005075_abnormal_melanosome_morpholog | 1.44014513 |
| 34 | MP0000313_abnormal_cell_death | 1.41365834 |
| 35 | MP0005410_abnormal_fertilization | 1.38787885 |
| 36 | MP0006036_abnormal_mitochondrial_physio | 1.36546978 |
| 37 | MP0003763_abnormal_thymus_physiology | 1.33890789 |
| 38 | MP0002019_abnormal_tumor_incidence | 1.30836414 |
| 39 | MP0001986_abnormal_taste_sensitivity | 1.27093717 |
| 40 | MP0009697_abnormal_copulation | 1.25764242 |
| 41 | MP0003011_delayed_dark_adaptation | 1.25309778 |
| 42 | MP0001853_heart_inflammation | 1.24564668 |
| 43 | MP0002102_abnormal_ear_morphology | 1.21476776 |
| 44 | MP0005670_abnormal_white_adipose | 1.21357345 |
| 45 | MP0005174_abnormal_tail_pigmentation | 1.21228417 |
| 46 | MP0002938_white_spotting | 1.20475962 |
| 47 | MP0005636_abnormal_mineral_homeostasis | 1.18729566 |
| 48 | MP0001835_abnormal_antigen_presentation | 1.18473430 |
| 49 | MP0001697_abnormal_embryo_size | 1.17547410 |
| 50 | MP0002398_abnormal_bone_marrow | 1.17420730 |
| 51 | MP0005397_hematopoietic_system_phenotyp | 1.16983416 |
| 52 | MP0001545_abnormal_hematopoietic_system | 1.16983416 |
| 53 | MP0006035_abnormal_mitochondrial_morpho | 1.15391385 |
| 54 | MP0002736_abnormal_nociception_after | 1.15077809 |
| 55 | MP0002148_abnormal_hypersensitivity_rea | 1.15070062 |
| 56 | MP0001727_abnormal_embryo_implantation | 1.13462765 |
| 57 | MP0002160_abnormal_reproductive_system | 1.13353090 |
| 58 | MP0002080_prenatal_lethality | 1.13019966 |
| 59 | MP0005645_abnormal_hypothalamus_physiol | 1.12828229 |
| 60 | MP0002722_abnormal_immune_system | 1.11732121 |
| 61 | MP0005408_hypopigmentation | 1.11655007 |
| 62 | MP0005671_abnormal_response_to | 1.09838332 |
| 63 | MP0005332_abnormal_amino_acid | 1.09498095 |
| 64 | MP0000858_altered_metastatic_potential | 1.08890239 |
| 65 | MP0000015_abnormal_ear_pigmentation | 1.08435833 |
| 66 | MP0000689_abnormal_spleen_morphology | 1.07110319 |
| 67 | MP0000703_abnormal_thymus_morphology | 1.05777810 |
| 68 | MP0005646_abnormal_pituitary_gland | 1.02729710 |
| 69 | MP0004808_abnormal_hematopoietic_stem | 1.02307727 |
| 70 | MP0009785_altered_susceptibility_to | 1.01117533 |
| 71 | MP0002429_abnormal_blood_cell | 1.00921917 |
| 72 | MP0002234_abnormal_pharynx_morphology | 1.00134172 |
| 73 | MP0002210_abnormal_sex_determination | 1.00102492 |
| 74 | MP0008875_abnormal_xenobiotic_pharmacok | 0.99507193 |
| 75 | MP0006072_abnormal_retinal_apoptosis | 0.99270417 |
| 76 | MP0000372_irregular_coat_pigmentation | 0.98974760 |
| 77 | MP0000358_abnormal_cell_content/ | 0.98911959 |
| 78 | MP0002095_abnormal_skin_pigmentation | 0.97587539 |
| 79 | MP0004142_abnormal_muscle_tone | 0.96881701 |
| 80 | MP0005394_taste/olfaction_phenotype | 0.95614692 |
| 81 | MP0005499_abnormal_olfactory_system | 0.95614692 |
| 82 | MP0002085_abnormal_embryonic_tissue | 0.95363187 |
| 83 | MP0001672_abnormal_embryogenesis/_devel | 0.94916642 |
| 84 | MP0005380_embryogenesis_phenotype | 0.94916642 |
| 85 | MP0002163_abnormal_gland_morphology | 0.93730369 |
| 86 | MP0008260_abnormal_autophagy | 0.93347557 |
| 87 | MP0003567_abnormal_fetal_cardiomyocyte | 0.93343330 |
| 88 | MP0008872_abnormal_physiological_respon | 0.92537960 |
| 89 | MP0001919_abnormal_reproductive_system | 0.91907494 |
| 90 | MP0000716_abnormal_immune_system | 0.90471512 |
| 91 | MP0005389_reproductive_system_phenotype | 0.90327301 |
| 92 | MP0004147_increased_porphyrin_level | 0.90234449 |
| 93 | MP0004381_abnormal_hair_follicle | 0.89690760 |
| 94 | MP0010030_abnormal_orbit_morphology | 0.89376027 |
| 95 | MP0000678_abnormal_parathyroid_gland | 0.88844815 |
| 96 | MP0001145_abnormal_male_reproductive | 0.87772317 |
| 97 | MP0002420_abnormal_adaptive_immunity | 0.87631908 |
| 98 | MP0005025_abnormal_response_to | 0.87516882 |
| 99 | MP0001881_abnormal_mammary_gland | 0.87379921 |
| 100 | MP0001819_abnormal_immune_cell | 0.87187044 |
| 101 | MP0001905_abnormal_dopamine_level | 0.84976518 |
| 102 | MP0002405_respiratory_system_inflammati | 0.84620569 |
| 103 | MP0001293_anophthalmia | 0.84396962 |
| 104 | MP0008873_increased_physiological_sensi | 0.83398393 |
| 105 | MP0005000_abnormal_immune_tolerance | 0.81864894 |
| 106 | MP0005319_abnormal_enzyme/_coenzyme | 0.80916733 |
| 107 | MP0002653_abnormal_ependyma_morphology | 0.79920724 |
| 108 | MP0000049_abnormal_middle_ear | 0.79810321 |
| 109 | MP0002723_abnormal_immune_serum | 0.79529684 |
| 110 | MP0003698_abnormal_male_reproductive | 0.79528225 |
| 111 | MP0002452_abnormal_antigen_presenting | 0.78982664 |
| 112 | MP0001873_stomach_inflammation | 0.78473922 |
| 113 | MP0001800_abnormal_humoral_immune | 0.76576233 |
| 114 | MP0001968_abnormal_touch/_nociception | 0.76499641 |
| 115 | MP0005451_abnormal_body_composition | 0.74707374 |
| 116 | MP0003984_embryonic_growth_retardation | 0.74495511 |
| 117 | MP0008995_early_reproductive_senescence | 0.74237368 |
| 118 | MP0001929_abnormal_gametogenesis | 0.73976216 |
| 119 | MP0000653_abnormal_sex_gland | 0.73071233 |
| 120 | MP0001119_abnormal_female_reproductive | 0.72461386 |
| 121 | MP0001542_abnormal_bone_strength | 0.71577313 |
| 122 | MP0002088_abnormal_embryonic_growth/wei | 0.70969825 |
| 123 | MP0002139_abnormal_hepatobiliary_system | 0.70770567 |
| 124 | MP0002876_abnormal_thyroid_physiology | 0.70441107 |
| 125 | MP0002277_abnormal_respiratory_mucosa | 0.69700473 |
| 126 | MP0003436_decreased_susceptibility_to | 0.68681549 |
| 127 | MP0010352_gastrointestinal_tract_polyps | 0.67175001 |
| 128 | MP0001188_hyperpigmentation | 0.64743964 |
| 129 | MP0002822_catalepsy | 0.64676451 |
| 130 | MP0000685_abnormal_immune_system | 0.63767630 |
| 131 | MP0005409_darkened_coat_color | 0.63654934 |
| 132 | MP0006054_spinal_hemorrhage | 0.63244138 |
| 133 | MP0005266_abnormal_metabolism | 0.63098830 |
| 134 | MP0003121_genomic_imprinting | 0.62408059 |
| 135 | MP0002084_abnormal_developmental_patter | 0.62274468 |
| 136 | MP0001346_abnormal_lacrimal_gland | 0.62257039 |
| 137 | MP0003646_muscle_fatigue | 0.58533544 |
| 138 | MP0009643_abnormal_urine_homeostasis | 0.55837959 |
| 139 | MP0009765_abnormal_xenobiotic_induced | 0.54631449 |
| 140 | MP0002693_abnormal_pancreas_physiology | 0.52510826 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 6.47545657 |
| 2 | Abnormal number of erythroid precursors (HP:0012131) | 6.04037829 |
| 3 | Reticulocytopenia (HP:0001896) | 5.69223388 |
| 4 | Birth length less than 3rd percentile (HP:0003561) | 4.27669258 |
| 5 | Macrocytic anemia (HP:0001972) | 4.26307425 |
| 6 | Acute necrotizing encephalopathy (HP:0006965) | 4.15381618 |
| 7 | Pallor (HP:0000980) | 4.03151262 |
| 8 | Mitochondrial inheritance (HP:0001427) | 3.87949544 |
| 9 | Breast hypoplasia (HP:0003187) | 3.72270608 |
| 10 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.64728815 |
| 11 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.64728815 |
| 12 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.62548457 |
| 13 | Hepatocellular necrosis (HP:0001404) | 3.50866202 |
| 14 | Increased hepatocellular lipid droplets (HP:0006565) | 3.50043770 |
| 15 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.46765526 |
| 16 | Increased CSF lactate (HP:0002490) | 3.46286396 |
| 17 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.38341332 |
| 18 | Aplastic anemia (HP:0001915) | 3.33678004 |
| 19 | Acute encephalopathy (HP:0006846) | 3.17240304 |
| 20 | 3-Methylglutaconic aciduria (HP:0003535) | 3.17095647 |
| 21 | Progressive macrocephaly (HP:0004481) | 3.15799632 |
| 22 | Cerebral hypomyelination (HP:0006808) | 3.10529603 |
| 23 | Oral leukoplakia (HP:0002745) | 3.10114674 |
| 24 | Exertional dyspnea (HP:0002875) | 3.00624487 |
| 25 | Rough bone trabeculation (HP:0100670) | 3.00353535 |
| 26 | Increased serum lactate (HP:0002151) | 2.97039675 |
| 27 | Lipid accumulation in hepatocytes (HP:0006561) | 2.96664177 |
| 28 | Hepatic necrosis (HP:0002605) | 2.94496619 |
| 29 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.87987899 |
| 30 | Renal Fanconi syndrome (HP:0001994) | 2.83285057 |
| 31 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.82506854 |
| 32 | Type I transferrin isoform profile (HP:0003642) | 2.82038550 |
| 33 | Chromsome breakage (HP:0040012) | 2.81009125 |
| 34 | Lethargy (HP:0001254) | 2.73377216 |
| 35 | Carpal bone hypoplasia (HP:0001498) | 2.69344413 |
| 36 | Abnormality of renal resorption (HP:0011038) | 2.62598395 |
| 37 | Patellar aplasia (HP:0006443) | 2.59703632 |
| 38 | Absent thumb (HP:0009777) | 2.55647041 |
| 39 | Respiratory difficulties (HP:0002880) | 2.55321643 |
| 40 | Abnormality of the preputium (HP:0100587) | 2.54454237 |
| 41 | Meckel diverticulum (HP:0002245) | 2.50977047 |
| 42 | Exercise intolerance (HP:0003546) | 2.50558947 |
| 43 | Abnormality of glycolysis (HP:0004366) | 2.50519224 |
| 44 | Increased serum pyruvate (HP:0003542) | 2.50519224 |
| 45 | Duplicated collecting system (HP:0000081) | 2.50338687 |
| 46 | Generalized aminoaciduria (HP:0002909) | 2.49451266 |
| 47 | Abnormality of urine glucose concentration (HP:0011016) | 2.47785484 |
| 48 | Glycosuria (HP:0003076) | 2.47785484 |
| 49 | Microretrognathia (HP:0000308) | 2.45796558 |
| 50 | CNS demyelination (HP:0007305) | 2.45521829 |
| 51 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.44695600 |
| 52 | Respiratory failure (HP:0002878) | 2.43313131 |
| 53 | Increased intramyocellular lipid droplets (HP:0012240) | 2.43034774 |
| 54 | Abnormality of the ileum (HP:0001549) | 2.42735295 |
| 55 | Premature graying of hair (HP:0002216) | 2.39445791 |
| 56 | Emotional lability (HP:0000712) | 2.38285165 |
| 57 | 11 pairs of ribs (HP:0000878) | 2.36959400 |
| 58 | Selective tooth agenesis (HP:0001592) | 2.36197743 |
| 59 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.35417779 |
| 60 | Dicarboxylic aciduria (HP:0003215) | 2.35417779 |
| 61 | Trismus (HP:0000211) | 2.33889787 |
| 62 | Lactic acidosis (HP:0003128) | 2.32821588 |
| 63 | Microvesicular hepatic steatosis (HP:0001414) | 2.31344649 |
| 64 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.30885886 |
| 65 | Methylmalonic aciduria (HP:0012120) | 2.29791745 |
| 66 | Pancytopenia (HP:0001876) | 2.29415520 |
| 67 | Triphalangeal thumb (HP:0001199) | 2.27765721 |
| 68 | Bone marrow hypocellularity (HP:0005528) | 2.26803170 |
| 69 | Cleft eyelid (HP:0000625) | 2.24251941 |
| 70 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.23355078 |
| 71 | Abnormal trabecular bone morphology (HP:0100671) | 2.23266902 |
| 72 | Hyperphosphaturia (HP:0003109) | 2.19062354 |
| 73 | Multiple enchondromatosis (HP:0005701) | 2.14491277 |
| 74 | Reduced antithrombin III activity (HP:0001976) | 2.14379775 |
| 75 | Muscle fiber atrophy (HP:0100295) | 2.13395002 |
| 76 | Absent radius (HP:0003974) | 2.12997144 |
| 77 | Abnormality of the renal collecting system (HP:0004742) | 2.12368247 |
| 78 | Horseshoe kidney (HP:0000085) | 2.11841361 |
| 79 | Premature ovarian failure (HP:0008209) | 2.10453036 |
| 80 | Abnormality of the anterior horn cell (HP:0006802) | 2.09179433 |
| 81 | Degeneration of anterior horn cells (HP:0002398) | 2.09179433 |
| 82 | Abnormality of chromosome stability (HP:0003220) | 2.09136613 |
| 83 | Asplenia (HP:0001746) | 2.08533757 |
| 84 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.08440088 |
| 85 | Leukodystrophy (HP:0002415) | 2.06616434 |
| 86 | Secondary amenorrhea (HP:0000869) | 2.06600501 |
| 87 | Hyperglycinemia (HP:0002154) | 2.04842212 |
| 88 | Sparse eyelashes (HP:0000653) | 2.04813625 |
| 89 | Poor head control (HP:0002421) | 2.04223118 |
| 90 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.99418795 |
| 91 | Absent forearm bone (HP:0003953) | 1.97825452 |
| 92 | Aplasia involving forearm bones (HP:0009822) | 1.97825452 |
| 93 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 1.97219890 |
| 94 | Cellular immunodeficiency (HP:0005374) | 1.97069640 |
| 95 | Colon cancer (HP:0003003) | 1.95541246 |
| 96 | Methylmalonic acidemia (HP:0002912) | 1.95170616 |
| 97 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.93622835 |
| 98 | Abnormal protein glycosylation (HP:0012346) | 1.93622835 |
| 99 | Abnormal glycosylation (HP:0012345) | 1.93622835 |
| 100 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.93622835 |
| 101 | Hypoplasia of the radius (HP:0002984) | 1.93009681 |
| 102 | Progressive microcephaly (HP:0000253) | 1.92549630 |
| 103 | Type 2 muscle fiber atrophy (HP:0003554) | 1.92448994 |
| 104 | Myelodysplasia (HP:0002863) | 1.89989910 |
| 105 | Duodenal stenosis (HP:0100867) | 1.89686962 |
| 106 | Small intestinal stenosis (HP:0012848) | 1.89686962 |
| 107 | Increased muscle lipid content (HP:0009058) | 1.88654467 |
| 108 | Abnormality of reticulocytes (HP:0004312) | 1.87703280 |
| 109 | Cerebral edema (HP:0002181) | 1.87244879 |
| 110 | Petechiae (HP:0000967) | 1.86946965 |
| 111 | IgM deficiency (HP:0002850) | 1.86826697 |
| 112 | X-linked dominant inheritance (HP:0001423) | 1.85976024 |
| 113 | Thrombocytosis (HP:0001894) | 1.84426203 |
| 114 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 1.84401984 |
| 115 | Blindness (HP:0000618) | 1.81114775 |
| 116 | Supernumerary spleens (HP:0009799) | 1.80979599 |
| 117 | Optic disc pallor (HP:0000543) | 1.80625918 |
| 118 | Abnormal lung lobation (HP:0002101) | 1.79196990 |
| 119 | Gliosis (HP:0002171) | 1.77431193 |
| 120 | Vomiting (HP:0002013) | 1.76821213 |
| 121 | Testicular atrophy (HP:0000029) | 1.75210122 |
| 122 | Opisthotonus (HP:0002179) | 1.73416707 |
| 123 | Sclerocornea (HP:0000647) | 1.69500449 |
| 124 | Abnormality of alanine metabolism (HP:0010916) | 1.67679058 |
| 125 | Hyperalaninemia (HP:0003348) | 1.67679058 |
| 126 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.67679058 |
| 127 | Neutropenia (HP:0001875) | 1.66177722 |
| 128 | Progressive muscle weakness (HP:0003323) | 1.65559499 |
| 129 | Abnormality of methionine metabolism (HP:0010901) | 1.65071566 |
| 130 | Redundant skin (HP:0001582) | 1.62572085 |
| 131 | Severe visual impairment (HP:0001141) | 1.60884544 |
| 132 | Ragged-red muscle fibers (HP:0003200) | 1.60847482 |
| 133 | Nausea (HP:0002018) | 1.60155282 |
| 134 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.59403553 |
| 135 | Abnormal urine phosphate concentration (HP:0012599) | 1.57063098 |
| 136 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.54465836 |
| 137 | Abnormality of serum amino acid levels (HP:0003112) | 1.54464519 |
| 138 | Death in infancy (HP:0001522) | 1.53181538 |
| 139 | Cerebral palsy (HP:0100021) | 1.52070176 |
| 140 | Pancreatic cysts (HP:0001737) | 1.51804214 |
| 141 | Abnormality of midbrain morphology (HP:0002418) | 1.50689994 |
| 142 | Molar tooth sign on MRI (HP:0002419) | 1.50689994 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 6.53318485 |
| 2 | BUB1 | 4.87806425 |
| 3 | NME2 | 4.43996148 |
| 4 | STK16 | 3.90160264 |
| 5 | WEE1 | 3.85499840 |
| 6 | VRK1 | 2.77249631 |
| 7 | EIF2AK1 | 2.56055368 |
| 8 | PIM2 | 2.49793705 |
| 9 | SRPK1 | 2.39266879 |
| 10 | TESK2 | 2.31842756 |
| 11 | CDC7 | 2.16800052 |
| 12 | TLK1 | 2.11637958 |
| 13 | EIF2AK3 | 2.04767924 |
| 14 | PLK4 | 2.02740611 |
| 15 | NME1 | 1.89703906 |
| 16 | NUAK1 | 1.81057565 |
| 17 | TAF1 | 1.77621237 |
| 18 | DYRK3 | 1.76057492 |
| 19 | ARAF | 1.71378880 |
| 20 | BRSK2 | 1.62657073 |
| 21 | PDK2 | 1.60264403 |
| 22 | MST4 | 1.51262292 |
| 23 | PLK1 | 1.47822042 |
| 24 | MKNK1 | 1.47237124 |
| 25 | TTK | 1.46185553 |
| 26 | KDR | 1.46029566 |
| 27 | TSSK6 | 1.45312868 |
| 28 | BRAF | 1.44468559 |
| 29 | NEK2 | 1.42163973 |
| 30 | CDK7 | 1.39695064 |
| 31 | MAP4K2 | 1.36445975 |
| 32 | PBK | 1.29256405 |
| 33 | AURKB | 1.28740709 |
| 34 | AURKA | 1.27201623 |
| 35 | CCNB1 | 1.20948931 |
| 36 | RPS6KB2 | 1.16827122 |
| 37 | MAP3K11 | 1.15242023 |
| 38 | ACVR1B | 1.13672609 |
| 39 | MAP4K1 | 1.12879327 |
| 40 | RPS6KA4 | 1.10896429 |
| 41 | DYRK2 | 1.08990757 |
| 42 | MKNK2 | 1.08589098 |
| 43 | CDK8 | 1.06098345 |
| 44 | DAPK1 | 1.05123530 |
| 45 | ATR | 1.04486876 |
| 46 | CDK19 | 1.04328088 |
| 47 | EPHA2 | 1.00946240 |
| 48 | BRSK1 | 1.00100275 |
| 49 | MAP3K8 | 0.99702945 |
| 50 | EIF2AK2 | 0.98297327 |
| 51 | PAK4 | 0.98290703 |
| 52 | TESK1 | 0.96064285 |
| 53 | ABL2 | 0.95049260 |
| 54 | BLK | 0.92530165 |
| 55 | PASK | 0.91254838 |
| 56 | SMG1 | 0.91063709 |
| 57 | LIMK1 | 0.89235228 |
| 58 | PAK1 | 0.88954199 |
| 59 | IRAK4 | 0.87060092 |
| 60 | PLK3 | 0.86629003 |
| 61 | PIM1 | 0.86410603 |
| 62 | CHEK2 | 0.84138080 |
| 63 | IRAK3 | 0.83316310 |
| 64 | ZAK | 0.81320365 |
| 65 | RPS6KA5 | 0.80909891 |
| 66 | CSNK2A1 | 0.78183812 |
| 67 | TRIM28 | 0.77709689 |
| 68 | CSNK1G1 | 0.77451041 |
| 69 | STK4 | 0.75490120 |
| 70 | STK10 | 0.74420373 |
| 71 | NEK1 | 0.74280427 |
| 72 | ILK | 0.73767840 |
| 73 | CSNK1G2 | 0.73480410 |
| 74 | CSNK2A2 | 0.71723857 |
| 75 | CLK1 | 0.71364283 |
| 76 | TEC | 0.68582705 |
| 77 | CSNK1A1L | 0.67930812 |
| 78 | MAP3K12 | 0.67846812 |
| 79 | IKBKB | 0.67266538 |
| 80 | GRK1 | 0.64305981 |
| 81 | INSRR | 0.61871498 |
| 82 | CHEK1 | 0.60916091 |
| 83 | PRKCI | 0.57538842 |
| 84 | PINK1 | 0.57376375 |
| 85 | WNK3 | 0.56035939 |
| 86 | LRRK2 | 0.55649549 |
| 87 | CDK4 | 0.54167983 |
| 88 | BTK | 0.53708733 |
| 89 | TXK | 0.51865904 |
| 90 | TGFBR1 | 0.50738858 |
| 91 | SCYL2 | 0.50409783 |
| 92 | BCKDK | 0.48156181 |
| 93 | MYLK | 0.48127377 |
| 94 | GRK5 | 0.47861296 |
| 95 | TAOK2 | 0.47160069 |
| 96 | DAPK3 | 0.46849778 |
| 97 | MAP2K7 | 0.46425561 |
| 98 | MAP2K2 | 0.44909312 |
| 99 | ADRBK2 | 0.44430056 |
| 100 | TIE1 | 0.43053076 |
| 101 | CSNK1G3 | 0.40832795 |
| 102 | LYN | 0.40649290 |
| 103 | YES1 | 0.40365302 |
| 104 | GRK6 | 0.39525864 |
| 105 | KIT | 0.38939481 |
| 106 | ZAP70 | 0.37889686 |
| 107 | CDK2 | 0.36978937 |
| 108 | MAP2K3 | 0.36665032 |
| 109 | TBK1 | 0.35169586 |
| 110 | GRK7 | 0.34004407 |
| 111 | RAF1 | 0.32336078 |
| 112 | MUSK | 0.31885353 |
| 113 | BMPR1B | 0.31471546 |
| 114 | ATM | 0.31374963 |
| 115 | SYK | 0.30861375 |
| 116 | BCR | 0.30808991 |
| 117 | ERN1 | 0.30766109 |
| 118 | MAPKAPK5 | 0.30484812 |
| 119 | CSNK1A1 | 0.30085990 |
| 120 | MAPKAPK3 | 0.29152662 |
| 121 | MAPKAPK2 | 0.28764607 |
| 122 | MARK3 | 0.28190444 |
| 123 | CDK11A | 0.28108914 |
| 124 | TNK2 | 0.26191715 |
| 125 | PRKCD | 0.26047772 |
| 126 | IKBKE | 0.22985014 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 5.43725782 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 4.31347979 |
| 3 | DNA replication_Homo sapiens_hsa03030 | 4.15711260 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 4.04954475 |
| 5 | Mismatch repair_Homo sapiens_hsa03430 | 3.47601046 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.87023757 |
| 7 | * Spliceosome_Homo sapiens_hsa03040 | 2.85656021 |
| 8 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.80643436 |
| 9 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.77898348 |
| 10 | Homologous recombination_Homo sapiens_hsa03440 | 2.73085966 |
| 11 | Base excision repair_Homo sapiens_hsa03410 | 2.70717565 |
| 12 | Parkinsons disease_Homo sapiens_hsa05012 | 2.53324471 |
| 13 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.52891985 |
| 14 | RNA transport_Homo sapiens_hsa03013 | 2.27562556 |
| 15 | Protein export_Homo sapiens_hsa03060 | 2.07886827 |
| 16 | Huntingtons disease_Homo sapiens_hsa05016 | 2.05379550 |
| 17 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.88360407 |
| 18 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.81228307 |
| 19 | Cell cycle_Homo sapiens_hsa04110 | 1.80952771 |
| 20 | Basal transcription factors_Homo sapiens_hsa03022 | 1.80705909 |
| 21 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.63018178 |
| 22 | RNA degradation_Homo sapiens_hsa03018 | 1.61858247 |
| 23 | Alzheimers disease_Homo sapiens_hsa05010 | 1.60705728 |
| 24 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.59124471 |
| 25 | Purine metabolism_Homo sapiens_hsa00230 | 1.51351648 |
| 26 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.50257444 |
| 27 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.47454204 |
| 28 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.45761130 |
| 29 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.43998738 |
| 30 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.28421005 |
| 31 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.22346964 |
| 32 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.21241416 |
| 33 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.13525482 |
| 34 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.09616778 |
| 35 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.07397703 |
| 36 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.05200209 |
| 37 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.99088778 |
| 38 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.97964621 |
| 39 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.97482001 |
| 40 | Sulfur relay system_Homo sapiens_hsa04122 | 0.90243546 |
| 41 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.87795180 |
| 42 | Peroxisome_Homo sapiens_hsa04146 | 0.87622175 |
| 43 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.85831337 |
| 44 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.84406788 |
| 45 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.84188571 |
| 46 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.83493945 |
| 47 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.79726080 |
| 48 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.78208106 |
| 49 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.73002741 |
| 50 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.70286237 |
| 51 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.69800607 |
| 52 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.68529167 |
| 53 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.66494059 |
| 54 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.64255178 |
| 55 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.63329892 |
| 56 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.63278239 |
| 57 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.61917419 |
| 58 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.58024648 |
| 59 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.53507154 |
| 60 | Metabolic pathways_Homo sapiens_hsa01100 | 0.52168371 |
| 61 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.49902125 |
| 62 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.49256461 |
| 63 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.48922448 |
| 64 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.44586777 |
| 65 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.44465625 |
| 66 | Asthma_Homo sapiens_hsa05310 | 0.44350843 |
| 67 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.44090563 |
| 68 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.43712866 |
| 69 | Allograft rejection_Homo sapiens_hsa05330 | 0.43444549 |
| 70 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.43130798 |
| 71 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.42559719 |
| 72 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.42198943 |
| 73 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.42026730 |
| 74 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.40543025 |
| 75 | Legionellosis_Homo sapiens_hsa05134 | 0.39292578 |
| 76 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.38746707 |
| 77 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.38193633 |
| 78 | Shigellosis_Homo sapiens_hsa05131 | 0.38163298 |
| 79 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.37955598 |
| 80 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.37570849 |
| 81 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.36410492 |
| 82 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.35949124 |
| 83 | HTLV-I infection_Homo sapiens_hsa05166 | 0.35229981 |
| 84 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.32573920 |
| 85 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.30325408 |
| 86 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.30221292 |
| 87 | Apoptosis_Homo sapiens_hsa04210 | 0.29628771 |
| 88 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.28841785 |
| 89 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.28091193 |
| 90 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.28005306 |
| 91 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.27470980 |
| 92 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.27245888 |
| 93 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.26948796 |
| 94 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.26700808 |
| 95 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.25469662 |
| 96 | Measles_Homo sapiens_hsa05162 | 0.25335527 |
| 97 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.24691534 |
| 98 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.24552139 |
| 99 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.23652790 |
| 100 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.23416644 |
| 101 | Alcoholism_Homo sapiens_hsa05034 | 0.22255770 |
| 102 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.21777393 |
| 103 | Phototransduction_Homo sapiens_hsa04744 | 0.21232413 |
| 104 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.20928812 |
| 105 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.20656496 |
| 106 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.20513227 |
| 107 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.19992305 |
| 108 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.19119977 |
| 109 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.18291895 |
| 110 | Other glycan degradation_Homo sapiens_hsa00511 | 0.18217259 |
| 111 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.17626466 |
| 112 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.15382312 |
| 113 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.14985307 |
| 114 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.14279517 |
| 115 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.14189820 |
| 116 | Thyroid cancer_Homo sapiens_hsa05216 | 0.13881900 |
| 117 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.13611189 |
| 118 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.12711184 |
| 119 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.12276325 |
| 120 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.11221150 |
| 121 | Phagosome_Homo sapiens_hsa04145 | 0.10992106 |
| 122 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.10725373 |
| 123 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.10321161 |
| 124 | Hepatitis B_Homo sapiens_hsa05161 | 0.10306142 |
| 125 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.09137621 |
| 126 | Leishmaniasis_Homo sapiens_hsa05140 | 0.08839105 |
| 127 | Galactose metabolism_Homo sapiens_hsa00052 | 0.06838440 |
| 128 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.06731420 |
| 129 | Carbon metabolism_Homo sapiens_hsa01200 | 0.06024010 |
| 130 | Influenza A_Homo sapiens_hsa05164 | 0.05946804 |
| 131 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.05844892 |

