SFMBT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene shares high similarity with the Drosophila Scm (sex comb on midleg) gene. It encodes a protein which contains four malignant brain tumor repeat (mbt) domains and may be involved in antigen recognition. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)7.78898303
2male meiosis (GO:0007140)5.90236822
3monoubiquitinated protein deubiquitination (GO:0035520)5.68140068
4mitotic chromosome condensation (GO:0007076)5.22040258
5DNA methylation involved in gamete generation (GO:0043046)5.02611805
6regulation of meiosis I (GO:0060631)5.00911573
7meiotic cell cycle (GO:0051321)4.78273351
8mitotic sister chromatid cohesion (GO:0007064)4.76302905
9negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.70178574
10female gamete generation (GO:0007292)4.50027832
11male meiosis I (GO:0007141)4.48476222
12sister chromatid cohesion (GO:0007062)4.45070502
13synaptonemal complex assembly (GO:0007130)4.40312180
14synapsis (GO:0007129)4.28188255
15mitotic metaphase plate congression (GO:0007080)4.24952437
16oocyte maturation (GO:0001556)4.19190318
17meiotic chromosome segregation (GO:0045132)4.19091777
18synaptonemal complex organization (GO:0070193)4.07546453
19multicellular organism reproduction (GO:0032504)4.06638840
20histone H2A monoubiquitination (GO:0035518)4.04158772
21cellular ketone body metabolic process (GO:0046950)4.02626869
22regulation of meiosis (GO:0040020)3.99265121
23gene silencing by RNA (GO:0031047)3.96820185
24meiotic nuclear division (GO:0007126)3.88794524
25meiosis I (GO:0007127)3.88285859
26negative regulation of meiosis (GO:0045835)3.83303151
27nuclear pore complex assembly (GO:0051292)3.76389969
28negative regulation of hormone biosynthetic process (GO:0032353)3.73162511
29negative regulation of hormone metabolic process (GO:0032351)3.73162511
30ketone body metabolic process (GO:1902224)3.71085559
31cytoplasmic mRNA processing body assembly (GO:0033962)3.70272292
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.70095596
33metaphase plate congression (GO:0051310)3.68093640
34fusion of sperm to egg plasma membrane (GO:0007342)3.61851297
35regulation of sister chromatid cohesion (GO:0007063)3.55177051
36regulation of DNA endoreduplication (GO:0032875)3.54653664
37DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.49471664
38establishment of chromosome localization (GO:0051303)3.48835216
39urea cycle (GO:0000050)3.45446920
40urea metabolic process (GO:0019627)3.45446920
41mitotic sister chromatid segregation (GO:0000070)3.45367707
42rRNA catabolic process (GO:0016075)3.45123136
43regulation of female gonad development (GO:2000194)3.45022951
44regulation of retinoic acid receptor signaling pathway (GO:0048385)3.43647072
45centriole replication (GO:0007099)3.41051070
46DNA methylation (GO:0006306)3.40144667
47DNA alkylation (GO:0006305)3.40144667
48DNA damage response, signal transduction resulting in transcription (GO:0042772)3.39901734
49attachment of spindle microtubules to kinetochore (GO:0008608)3.32653119
50chromosome organization involved in meiosis (GO:0070192)3.29977754
51regulation of hexokinase activity (GO:1903299)3.26087756
52regulation of glucokinase activity (GO:0033131)3.26087756
53meiotic cell cycle process (GO:1903046)3.23498956
54DNA deamination (GO:0045006)3.23427886
55reproduction (GO:0000003)3.21636740
56reciprocal meiotic recombination (GO:0007131)3.20525586
57reciprocal DNA recombination (GO:0035825)3.20525586
58cilium or flagellum-dependent cell motility (GO:0001539)3.14483227
59negative regulation of DNA-dependent DNA replication (GO:2000104)3.14195358
60DNA damage induced protein phosphorylation (GO:0006975)3.13499201
61fucose catabolic process (GO:0019317)3.13461804
62L-fucose metabolic process (GO:0042354)3.13461804
63L-fucose catabolic process (GO:0042355)3.13461804
64chromosome segregation (GO:0007059)3.10251759
65regulation of centriole replication (GO:0046599)3.09520172
66protein localization to chromosome, centromeric region (GO:0071459)3.08505057
67regulation of meiotic cell cycle (GO:0051445)3.07873123
68oogenesis (GO:0048477)3.06168369
69positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.06056137
70positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.06056137
71positive regulation of mitotic sister chromatid separation (GO:1901970)3.06056137
72sister chromatid segregation (GO:0000819)3.04020144
73microtubule nucleation (GO:0007020)3.02926953
74water-soluble vitamin biosynthetic process (GO:0042364)3.00789264
75protein K11-linked deubiquitination (GO:0035871)2.98377848
76kinetochore organization (GO:0051383)2.96819155
77nitrogen cycle metabolic process (GO:0071941)2.95984980
78snRNA transcription (GO:0009301)2.93654430
79replication fork processing (GO:0031297)2.93408648
80microtubule depolymerization (GO:0007019)2.92753563
81kinetochore assembly (GO:0051382)2.92465737
82resolution of meiotic recombination intermediates (GO:0000712)2.92356454
83regulation of RIG-I signaling pathway (GO:0039535)2.91973721
84histone H2A ubiquitination (GO:0033522)2.91878077
85macroautophagy (GO:0016236)2.91605514
86regulation of nuclear cell cycle DNA replication (GO:0033262)2.90330708
87double-strand break repair via homologous recombination (GO:0000724)2.88849528
88nuclear pore organization (GO:0006999)2.88628062
89recombinational repair (GO:0000725)2.87883055
90protein K6-linked ubiquitination (GO:0085020)2.85461229
91type B pancreatic cell development (GO:0003323)2.85206551
92DNA replication checkpoint (GO:0000076)2.84176827
93RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.84012585
94chromosome condensation (GO:0030261)2.83460215
95protein localization to chromosome (GO:0034502)2.81952282
96fertilization (GO:0009566)2.80392694
97sperm-egg recognition (GO:0035036)2.79700447
98regulation of mononuclear cell migration (GO:0071675)2.78424269
99axonemal dynein complex assembly (GO:0070286)2.76381118
100gene silencing (GO:0016458)2.75899755
101N-terminal protein amino acid acetylation (GO:0006474)2.74037248
102regulation of DNA methylation (GO:0044030)2.72765461
103female gonad development (GO:0008585)2.71721041
104motile cilium assembly (GO:0044458)2.70833931
105regulation of histone H3-K27 methylation (GO:0061085)2.70629983
106pore complex assembly (GO:0046931)2.70607935
107histone lysine demethylation (GO:0070076)2.70292080
108regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.69792067
109positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.69792067
110maturation of 5.8S rRNA (GO:0000460)2.69669889
111respiratory chain complex IV assembly (GO:0008535)2.69396574
112centriole assembly (GO:0098534)2.68094736
113cell wall macromolecule metabolic process (GO:0044036)2.66721439
114cell wall macromolecule catabolic process (GO:0016998)2.66721439
115regulation of clathrin-mediated endocytosis (GO:2000369)2.65728718
116histone exchange (GO:0043486)2.65648783
117somatic diversification of immune receptors via somatic mutation (GO:0002566)2.63732994
118somatic hypermutation of immunoglobulin genes (GO:0016446)2.63732994
119* gamete generation (GO:0007276)2.63648273
120positive regulation of mRNA 3-end processing (GO:0031442)2.63405003
121acrosome assembly (GO:0001675)2.63162423
122binding of sperm to zona pellucida (GO:0007339)2.62877839
123DNA packaging (GO:0006323)2.61529196
124ncRNA catabolic process (GO:0034661)2.60579738
125histone H3-K36 demethylation (GO:0070544)2.60320884
126regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.59379188
127regulation of mitotic spindle checkpoint (GO:1903504)2.59379188
128intra-S DNA damage checkpoint (GO:0031573)2.59080739
129regulation of establishment of cell polarity (GO:2000114)2.58523615
130histone demethylation (GO:0016577)2.58476260
131spermatid development (GO:0007286)2.58211583
132regulation of chromosome segregation (GO:0051983)2.57957638
133protein localization to kinetochore (GO:0034501)2.57582638
134positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.57242064
135regulation of hippo signaling (GO:0035330)2.53038715
136keratinocyte development (GO:0003334)2.49186971
137double-strand break repair via nonhomologous end joining (GO:0006303)2.49107949
138non-recombinational repair (GO:0000726)2.49107949
139somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.48080730
140somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.48080730
141isotype switching (GO:0045190)2.48080730
142maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.48032953
143positive regulation of histone H3-K4 methylation (GO:0051571)2.47324974
144positive regulation of mRNA catabolic process (GO:0061014)2.46611710
145tryptophan catabolic process (GO:0006569)2.46569398
146indole-containing compound catabolic process (GO:0042436)2.46569398
147indolalkylamine catabolic process (GO:0046218)2.46569398
148establishment of protein localization to Golgi (GO:0072600)2.46162137
149somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.45988715
150somatic cell DNA recombination (GO:0016444)2.45988715
151axoneme assembly (GO:0035082)2.45353529
152somatic diversification of immune receptors (GO:0002200)2.43868252
153regulation of mRNA 3-end processing (GO:0031440)2.43825062
154regulation of centrosome cycle (GO:0046605)2.42873088
155cytochrome complex assembly (GO:0017004)2.42016898
156somatic recombination of immunoglobulin gene segments (GO:0016447)2.40793320
157sperm motility (GO:0030317)2.40546086
158regulation of centrosome duplication (GO:0010824)2.40239456
159regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.40062363
160positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.40062363
161positive regulation of defense response to virus by host (GO:0002230)2.39315785
162protein targeting to Golgi (GO:0000042)2.38936795
163somatic diversification of immunoglobulins (GO:0016445)2.38456763
164DNA recombination (GO:0006310)2.38436990
165V(D)J recombination (GO:0033151)2.38012850
166DNA replication-dependent nucleosome assembly (GO:0006335)2.36500360
167DNA replication-dependent nucleosome organization (GO:0034723)2.36500360
168double-strand break repair (GO:0006302)2.36149363
169kynurenine metabolic process (GO:0070189)2.35078938
170oocyte development (GO:0048599)2.34436210
171cAMP catabolic process (GO:0006198)2.34095727
172oxidative demethylation (GO:0070989)2.33840160

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.67989408
2E2F7_22180533_ChIP-Seq_HELA_Human4.42538690
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.17212369
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.47274663
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.38867828
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.35957916
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.09785106
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.69506421
9ZNF274_21170338_ChIP-Seq_K562_Hela2.64286954
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.55477165
11KAP1_22055183_ChIP-Seq_ESCs_Mouse2.49631542
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.49338848
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.44048393
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.42615234
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.36470478
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.30919118
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.26813738
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.24149540
19VDR_23849224_ChIP-Seq_CD4+_Human2.10538971
20IRF1_19129219_ChIP-ChIP_H3396_Human2.10300333
21* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.04283275
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.01063183
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.96737319
24AR_21909140_ChIP-Seq_LNCAP_Human1.95770161
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.90024915
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89419801
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89135544
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.87190988
29ELK1_19687146_ChIP-ChIP_HELA_Human1.87010095
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.85425641
31LXR_22158963_ChIP-Seq_LIVER_Mouse1.85062277
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.84565740
33VDR_22108803_ChIP-Seq_LS180_Human1.83351032
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82887840
35IGF1R_20145208_ChIP-Seq_DFB_Human1.81839302
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77477145
37* RXR_22158963_ChIP-Seq_LIVER_Mouse1.77166265
38* TAF15_26573619_Chip-Seq_HEK293_Human1.75012446
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.69101004
40ER_23166858_ChIP-Seq_MCF-7_Human1.68386231
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.67724809
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.66444550
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.65438545
44FOXP3_21729870_ChIP-Seq_TREG_Human1.64174794
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.64089585
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63046406
47ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.60499735
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56774796
49EWS_26573619_Chip-Seq_HEK293_Human1.55912290
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55503308
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54282126
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53937337
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.51680620
54CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.48708428
55ELK4_26923725_Chip-Seq_MESODERM_Mouse1.48630089
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.48591492
57IRF8_22096565_ChIP-ChIP_GC-B_Human1.48222470
58MYC_18940864_ChIP-ChIP_HL60_Human1.47137524
59PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.44858921
60RUNX1_26923725_Chip-Seq_HPCs_Mouse1.44197988
61CBP_20019798_ChIP-Seq_JUKART_Human1.42574219
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42574219
63IRF8_27001747_Chip-Seq_BMDM_Mouse1.36516266
64JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.36161882
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34103298
66ETS1_20019798_ChIP-Seq_JURKAT_Human1.32323542
67GATA1_26923725_Chip-Seq_HPCs_Mouse1.32159254
68TP53_22573176_ChIP-Seq_HFKS_Human1.31738532
69TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31718333
70GBX2_23144817_ChIP-Seq_PC3_Human1.30763443
71BP1_19119308_ChIP-ChIP_Hs578T_Human1.29576251
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29320006
73ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28687199
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.28537563
75STAT1_17558387_ChIP-Seq_HELA_Human1.28339195
76* E2F1_21310950_ChIP-Seq_MCF-7_Human1.28066447
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.26841467
78* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.26032405
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25982437
80GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25237939
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24729842
82STAT3_23295773_ChIP-Seq_U87_Human1.24286625
83GATA3_26560356_Chip-Seq_TH2_Human1.24202859
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24004285
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23934035
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21435119
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21435119
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.20992479
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18616908
90KDM5A_27292631_Chip-Seq_BREAST_Human1.18409820
91P300_19829295_ChIP-Seq_ESCs_Human1.18020351
92SRF_21415370_ChIP-Seq_HL-1_Mouse1.17814499
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17630029
94BCAT_22108803_ChIP-Seq_LS180_Human1.17071806
95HOXB7_26014856_ChIP-Seq_BT474_Human1.14854307
96* TCF4_23295773_ChIP-Seq_U87_Human1.13645130
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13493016
98GATA3_26560356_Chip-Seq_TH1_Human1.13382301
99TP63_19390658_ChIP-ChIP_HaCaT_Human1.13156223
100RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12852342
101CDX2_22108803_ChIP-Seq_LS180_Human1.12805464
102TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12594184
103CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12030526
104CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11602526
105GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11560480
106NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.10841203
107CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.10438822
108PKCTHETA_26484144_Chip-Seq_BREAST_Human1.09515704
109SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08779390
110FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08145447
111FOXA1_25329375_ChIP-Seq_VCAP_Human1.08145447
112AR_20517297_ChIP-Seq_VCAP_Human1.06780084
113MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06122537
114YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04761146
115FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.04716537
116IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.04667490
117MYB_26560356_Chip-Seq_TH2_Human1.04293163
118DCP1A_22483619_ChIP-Seq_HELA_Human1.02824462
119STAT3_18555785_Chip-Seq_ESCs_Mouse1.02172020
120OCT4_18555785_Chip-Seq_ESCs_Mouse1.01938253
121* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.01845645
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01349521
123* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01285949
124CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01133168
125KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00131386
126FOXA2_19822575_ChIP-Seq_HepG2_Human1.00084215
127ESRRB_18555785_Chip-Seq_ESCs_Mouse0.99980718
128NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99470977
129FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99431140
130CTCF_18555785_Chip-Seq_ESCs_Mouse0.98975404
131FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.98274881
132ESR1_20079471_ChIP-ChIP_T-47D_Human0.97602670
133NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96949054
134* PRDM14_20953172_ChIP-Seq_ESCs_Human0.96321468
135OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96197174
136SOX2_18555785_Chip-Seq_ESCs_Mouse0.95730795
137FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95521177
138HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95476524
139AR_25329375_ChIP-Seq_VCAP_Human0.95262312
140SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95200326
141NMYC_18555785_Chip-Seq_ESCs_Mouse0.94202316
142CMYC_18555785_Chip-Seq_ESCs_Mouse0.93947427
143ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93546212
144ETV1_20927104_ChIP-Seq_GIST48_Human0.93505046
145RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93044758
146EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.92950353
147SOX2_19829295_ChIP-Seq_ESCs_Human0.92701193
148NANOG_19829295_ChIP-Seq_ESCs_Human0.92701193
149KLF4_18555785_Chip-Seq_ESCs_Mouse0.92237355
150CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91957807
151E2F1_18555785_Chip-Seq_ESCs_Mouse0.91846059
152* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91294039
153TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90830071
154CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90760379
155FUS_26573619_Chip-Seq_HEK293_Human0.90312925
156TBL1_22424771_ChIP-Seq_293T_Human0.90302554
157RBPJ_21746931_ChIP-Seq_IB4_Human0.90301884
158SMRT_27268052_Chip-Seq_Bcells_Human0.90128665
159CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90007590
160KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.90002184
161SMAD4_21741376_ChIP-Seq_EPCs_Human0.89938852
162TCF4_22108803_ChIP-Seq_LS180_Human0.89907944
163NFYA_21822215_ChIP-Seq_K562_Human0.89376858
164SUZ12_18555785_Chip-Seq_ESCs_Mouse0.88662722
165FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88660864
166ZFX_18555785_Chip-Seq_ESCs_Mouse0.88006586
167P53_22387025_ChIP-Seq_ESCs_Mouse0.87271805
168CRX_20693478_ChIP-Seq_RETINA_Mouse0.86343622

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.74946890
2MP0002139_abnormal_hepatobiliary_system3.83576137
3MP0005451_abnormal_body_composition3.51560299
4MP0003787_abnormal_imprinting3.29455388
5MP0000569_abnormal_digit_pigmentation2.94737045
6MP0005365_abnormal_bile_salt2.94430500
7MP0003718_maternal_effect2.84271327
8MP0005360_urolithiasis2.81016246
9MP0002653_abnormal_ependyma_morphology2.73795707
10MP0001929_abnormal_gametogenesis2.72436743
11MP0000372_irregular_coat_pigmentation2.59572997
12MP0005410_abnormal_fertilization2.48050186
13MP0010094_abnormal_chromosome_stability2.38933634
14MP0010307_abnormal_tumor_latency2.35274536
15MP0003693_abnormal_embryo_hatching2.32204301
16MP0003252_abnormal_bile_duct2.30672984
17MP0005085_abnormal_gallbladder_physiolo2.30488492
18MP0002210_abnormal_sex_determination2.24813551
19MP0003646_muscle_fatigue2.18338030
20MP0002009_preneoplasia2.16793171
21MP0001119_abnormal_female_reproductive2.09025140
22MP0002163_abnormal_gland_morphology2.05719443
23MP0000653_abnormal_sex_gland2.04624948
24MP0003699_abnormal_female_reproductive2.03924997
25MP0002102_abnormal_ear_morphology1.97561902
26MP0003111_abnormal_nucleus_morphology1.96349358
27MP0003077_abnormal_cell_cycle1.95176408
28MP0005551_abnormal_eye_electrophysiolog1.88967936
29MP0005310_abnormal_salivary_gland1.88053714
30MP0008875_abnormal_xenobiotic_pharmacok1.87762410
31MP0003698_abnormal_male_reproductive1.79062037
32MP0003195_calcinosis1.78214620
33MP0006072_abnormal_retinal_apoptosis1.76357480
34MP0005075_abnormal_melanosome_morpholog1.74279202
35MP0005408_hypopigmentation1.73676023
36MP0008057_abnormal_DNA_replication1.71152695
37MP0001145_abnormal_male_reproductive1.70620095
38MP0010234_abnormal_vibrissa_follicle1.68607703
39MP0009840_abnormal_foam_cell1.68101769
40MP0001873_stomach_inflammation1.66164182
41MP0003121_genomic_imprinting1.65221168
42MP0005395_other_phenotype1.64217672
43MP0005076_abnormal_cell_differentiation1.61436465
44MP0004264_abnormal_extraembryonic_tissu1.59831703
45MP0002161_abnormal_fertility/fecundity1.59077587
46MP0002877_abnormal_melanocyte_morpholog1.58451488
47MP0004381_abnormal_hair_follicle1.58113357
48MP0003763_abnormal_thymus_physiology1.55526289
49MP0005253_abnormal_eye_physiology1.52554297
50MP0002876_abnormal_thyroid_physiology1.51883095
51MP0000015_abnormal_ear_pigmentation1.49135875
52MP0003123_paternal_imprinting1.48831169
53MP0001915_intracranial_hemorrhage1.48181306
54MP0003011_delayed_dark_adaptation1.48147742
55MP0005174_abnormal_tail_pigmentation1.48073199
56MP0001986_abnormal_taste_sensitivity1.39436758
57MP0003890_abnormal_embryonic-extraembry1.37917058
58MP0005645_abnormal_hypothalamus_physiol1.35500122
59MP0003786_premature_aging1.32690966
60MP0008007_abnormal_cellular_replicative1.32080334
61MP0002837_dystrophic_cardiac_calcinosis1.31934218
62MP0003868_abnormal_feces_composition1.31478755
63MP0000609_abnormal_liver_physiology1.26561135
64MP0005647_abnormal_sex_gland1.26471232
65MP0002138_abnormal_hepatobiliary_system1.22271291
66MP0008995_early_reproductive_senescence1.20919875
67MP0010329_abnormal_lipoprotein_level1.20765204
68MP0005397_hematopoietic_system_phenotyp1.20377061
69MP0001545_abnormal_hematopoietic_system1.20377061
70MP0005266_abnormal_metabolism1.18880940
71MP0002928_abnormal_bile_duct1.17601851
72MP0003656_abnormal_erythrocyte_physiolo1.17427070
73MP0004185_abnormal_adipocyte_glucose1.17367038
74MP0004142_abnormal_muscle_tone1.16999575
75MP0002160_abnormal_reproductive_system1.14025505
76MP0000639_abnormal_adrenal_gland1.13071369
77MP0010678_abnormal_skin_adnexa1.11905110
78MP0006036_abnormal_mitochondrial_physio1.10657160
79MP0006082_CNS_inflammation1.09868269
80MP0005646_abnormal_pituitary_gland1.09849688
81MP0004957_abnormal_blastocyst_morpholog1.09318167
82MP0002254_reproductive_system_inflammat1.08443580
83MP0000350_abnormal_cell_proliferation1.07660174
84MP0008058_abnormal_DNA_repair1.06315397
85MP0001835_abnormal_antigen_presentation1.04666087
86MP0006035_abnormal_mitochondrial_morpho1.03762800
87MP0003183_abnormal_peptide_metabolism1.02751105
88MP0004510_myositis1.02497842
89MP0002095_abnormal_skin_pigmentation1.02337711
90MP0003136_yellow_coat_color1.01867570
91MP0001851_eye_inflammation1.01653877
92MP0000371_diluted_coat_color1.01545272
93MP0005671_abnormal_response_to0.99328400
94MP0001730_embryonic_growth_arrest0.98846756
95MP0000579_abnormal_nail_morphology0.96805784
96MP0005248_abnormal_Harderian_gland0.95721662
97MP0003943_abnormal_hepatobiliary_system0.93536843
98MP0000383_abnormal_hair_follicle0.92283032
99MP0003191_abnormal_cellular_cholesterol0.91988275
100MP0005380_embryogenesis_phenotype0.90818000
101MP0001672_abnormal_embryogenesis/_devel0.90818000
102MP0004808_abnormal_hematopoietic_stem0.90442895
103MP0001764_abnormal_homeostasis0.90388453
104MP0001697_abnormal_embryo_size0.89770189
105MP0009672_abnormal_birth_weight0.89402196
106MP0006292_abnormal_olfactory_placode0.89078569
107MP0002090_abnormal_vision0.88542416
108MP0001919_abnormal_reproductive_system0.87662359
109MP0005332_abnormal_amino_acid0.87370475
110MP0001800_abnormal_humoral_immune0.87235077
111MP0000631_abnormal_neuroendocrine_gland0.86957232
112MP0000703_abnormal_thymus_morphology0.84587427
113MP0004043_abnormal_pH_regulation0.84567976
114MP0001666_abnormal_nutrient_absorption0.84228407
115MP0005389_reproductive_system_phenotype0.82976379
116MP0002019_abnormal_tumor_incidence0.82929553
117MP0002693_abnormal_pancreas_physiology0.81031993
118MP0009115_abnormal_fat_cell0.80637862
119MP0008961_abnormal_basal_metabolism0.80575008
120MP0008872_abnormal_physiological_respon0.79261348
121MP0003303_peritoneal_inflammation0.79023575
122MP0001485_abnormal_pinna_reflex0.78571134
123MP0005379_endocrine/exocrine_gland_phen0.76749189
124MP0002085_abnormal_embryonic_tissue0.76179033
125MP0009697_abnormal_copulation0.76150424
126MP0005391_vision/eye_phenotype0.75979005
127MP0002168_other_aberrant_phenotype0.75573337
128MP0002084_abnormal_developmental_patter0.75068872
129MP0003705_abnormal_hypodermis_morpholog0.74535534
130MP0003806_abnormal_nucleotide_metabolis0.74339144
131MP0001324_abnormal_eye_pigmentation0.74013839
132MP0003984_embryonic_growth_retardation0.73791866
133MP0002088_abnormal_embryonic_growth/wei0.72162883
134MP0000689_abnormal_spleen_morphology0.72156756
135MP0002166_altered_tumor_susceptibility0.71588551
136MP0000598_abnormal_liver_morphology0.71394352
137MP0002086_abnormal_extraembryonic_tissu0.71107857
138MP0002971_abnormal_brown_adipose0.69868818
139MP0002909_abnormal_adrenal_gland0.69529455
140MP0001944_abnormal_pancreas_morphology0.69004986
141MP0000604_amyloidosis0.68882988
142MP0004742_abnormal_vestibular_system0.68704871
143MP0001661_extended_life_span0.66585166
144MP0005187_abnormal_penis_morphology0.65916381
145MP0010386_abnormal_urinary_bladder0.65824115
146MP0000470_abnormal_stomach_morphology0.64524527
147MP0003937_abnormal_limbs/digits/tail_de0.64407334
148MP0001984_abnormal_olfaction0.64137780
149MP0009764_decreased_sensitivity_to0.63785059
150MP0002277_abnormal_respiratory_mucosa0.62372252
151MP0005621_abnormal_cell_physiology0.62246538
152MP0000566_synostosis0.61471559
153MP0000427_abnormal_hair_cycle0.61334496
154MP0002118_abnormal_lipid_homeostasis0.61147510
155MP0005220_abnormal_exocrine_pancreas0.61036260
156MP0000627_abnormal_mammary_gland0.60125866

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)5.90417811
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.16402304
3Male infertility (HP:0003251)4.74445829
4Abnormality of the fingertips (HP:0001211)4.07546869
5Chromsome breakage (HP:0040012)3.84472975
6Facial hemangioma (HP:0000329)3.71381846
7Renal cortical cysts (HP:0000803)3.60750655
8Abnormality of the renal cortex (HP:0011035)3.49254814
9Chronic bronchitis (HP:0004469)3.48320138
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.46179788
11Thyroid carcinoma (HP:0002890)3.30961645
12Infertility (HP:0000789)3.26870147
13Deep venous thrombosis (HP:0002625)3.20415611
14Acute myeloid leukemia (HP:0004808)3.20146144
15Complement deficiency (HP:0004431)3.15325492
16Pancreatic cysts (HP:0001737)3.09576554
17Cortical dysplasia (HP:0002539)3.06142855
18Abnormal respiratory motile cilium physiology (HP:0012261)3.01284974
19Prostate neoplasm (HP:0100787)2.95669086
20Abnormality of lateral ventricle (HP:0030047)2.95235834
21Azoospermia (HP:0000027)2.86878564
22Type II lissencephaly (HP:0007260)2.84157096
23Shawl scrotum (HP:0000049)2.79610305
24Rhinitis (HP:0012384)2.78674223
25Capillary hemangiomas (HP:0005306)2.71982505
26Myocardial infarction (HP:0001658)2.71801754
27Abnormality of chromosome stability (HP:0003220)2.64446480
28Abnormal spermatogenesis (HP:0008669)2.63760193
29Spontaneous abortion (HP:0005268)2.63312798
30Fair hair (HP:0002286)2.62034343
31Cerebellar dysplasia (HP:0007033)2.61400316
32Congenital stationary night blindness (HP:0007642)2.59651150
33Hyperglycemia (HP:0003074)2.54712191
34Thyroiditis (HP:0100646)2.49966660
35Recurrent gram-negative bacterial infections (HP:0005420)2.46868340
36Insulin-resistant diabetes mellitus (HP:0000831)2.45627719
37Upper motor neuron abnormality (HP:0002127)2.44316955
38Hypochromic microcytic anemia (HP:0004840)2.42958900
39Abnormal hair whorl (HP:0010721)2.42607857
40Absent/shortened dynein arms (HP:0200106)2.42494226
41Dynein arm defect of respiratory motile cilia (HP:0012255)2.42494226
42Hyperinsulinemic hypoglycemia (HP:0000825)2.40896830
43Intrahepatic cholestasis (HP:0001406)2.39625546
44Ketoacidosis (HP:0001993)2.37025295
45Methylmalonic acidemia (HP:0002912)2.35918299
46Abnormality of homocysteine metabolism (HP:0010919)2.33906562
47Homocystinuria (HP:0002156)2.33906562
48Abnormality of the labia minora (HP:0012880)2.33000155
49Severe combined immunodeficiency (HP:0004430)2.31749236
50Oligodactyly (hands) (HP:0001180)2.29365211
51Tubulointerstitial nephritis (HP:0001970)2.27874496
52Ectopic kidney (HP:0000086)2.27346526
53Heterotopia (HP:0002282)2.27047579
54Aplasia/Hypoplasia of the uvula (HP:0010293)2.26366303
55Sandal gap (HP:0001852)2.24717614
56Impulsivity (HP:0100710)2.24644819
57IgG deficiency (HP:0004315)2.24517070
58Disinhibition (HP:0000734)2.24249162
59Abnormality of complement system (HP:0005339)2.22914554
60T lymphocytopenia (HP:0005403)2.22676086
61Retrobulbar optic neuritis (HP:0100654)2.21045837
62Optic neuritis (HP:0100653)2.21045837
63Systemic lupus erythematosus (HP:0002725)2.20750387
64Autoimmune thrombocytopenia (HP:0001973)2.18951666
65Recurrent bacterial skin infections (HP:0005406)2.18258634
66Oligodactyly (HP:0012165)2.17157319
67Large for gestational age (HP:0001520)2.16636376
68Combined immunodeficiency (HP:0005387)2.13207058
69Abnormality of DNA repair (HP:0003254)2.13178411
70Lip pit (HP:0100267)2.12330867
71True hermaphroditism (HP:0010459)2.10644328
72Hypoplasia of the pons (HP:0012110)2.10578735
73Hypoglycemic coma (HP:0001325)2.09577828
74Abnormality of the pons (HP:0007361)2.09195164
75Sensorimotor neuropathy (HP:0007141)2.08665871
76Generalized hypopigmentation of hair (HP:0011358)2.06337333
77Nasal polyposis (HP:0100582)2.05328307
78Volvulus (HP:0002580)2.04247764
79Acanthocytosis (HP:0001927)2.03809465
80Abnormality of the prostate (HP:0008775)2.02401927
81Clubbing of toes (HP:0100760)2.01710128
82Stomach cancer (HP:0012126)2.01456345
83Abnormality of vitamin B metabolism (HP:0004340)2.00078937
84Glomerulonephritis (HP:0000099)1.99554312
85Bronchiectasis (HP:0002110)1.98218669
86Patellar aplasia (HP:0006443)1.97569087
87Abnormality of T cell number (HP:0011839)1.96019746
88Abnormal biliary tract physiology (HP:0012439)1.94685765
89Bile duct proliferation (HP:0001408)1.94685765
90Tubular atrophy (HP:0000092)1.94459041
91Epidermoid cyst (HP:0200040)1.93363633
92Abnormality of the carotid arteries (HP:0005344)1.93156623
93Molar tooth sign on MRI (HP:0002419)1.93068660
94Abnormality of midbrain morphology (HP:0002418)1.93068660
95Birth length less than 3rd percentile (HP:0003561)1.92705489
96Progressive inability to walk (HP:0002505)1.92125867
97Ketosis (HP:0001946)1.92077847
98Abnormality of the phalanges of the hallux (HP:0010057)1.91506183
99Nephronophthisis (HP:0000090)1.90365061
100Truncal obesity (HP:0001956)1.89540762
101Abnormality of the intrinsic pathway (HP:0010989)1.89192378
102Hypoglycemic seizures (HP:0002173)1.88746659
103Arterial thrombosis (HP:0004420)1.87434914
104Hypercholesterolemia (HP:0003124)1.85769554
105Intestinal atresia (HP:0011100)1.85658464
106Meckel diverticulum (HP:0002245)1.84224717
107Abnormality of chromosome segregation (HP:0002916)1.83948960
108Attenuation of retinal blood vessels (HP:0007843)1.83679934
109Microglossia (HP:0000171)1.83565747
110Protruding tongue (HP:0010808)1.81054509
111Orchitis (HP:0100796)1.79301118
112Gaze-evoked nystagmus (HP:0000640)1.79100899
113Myelodysplasia (HP:0002863)1.78020019
114Abnormality of the vitamin B12 metabolism (HP:0004341)1.76288807
115Abnormality of alanine metabolism (HP:0010916)1.75769388
116Hyperalaninemia (HP:0003348)1.75769388
117Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.75769388
118Aplasia/Hypoplasia of the patella (HP:0006498)1.75202372
119Methylmalonic aciduria (HP:0012120)1.75084177
120Aplasia/Hypoplasia of the tibia (HP:0005772)1.74276905
121Aplasia/Hypoplasia of the tongue (HP:0010295)1.73808524
122Global brain atrophy (HP:0002283)1.73094352
123Abnormality of the renal collecting system (HP:0004742)1.72185607
124Cystic liver disease (HP:0006706)1.71356265
125Sloping forehead (HP:0000340)1.71123597
126Abnormality of the ileum (HP:0001549)1.70877305
127Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.70870018
128Duplicated collecting system (HP:0000081)1.70468647
129Gastrointestinal infarctions (HP:0005244)1.69418003
130Bronchitis (HP:0012387)1.68466374
131Abnormality of the preputium (HP:0100587)1.67511852
132Joint hemorrhage (HP:0005261)1.67335066
133Primary amenorrhea (HP:0000786)1.67310462
134Dandy-Walker malformation (HP:0001305)1.66934170
135Aplasia/Hypoplasia of the spleen (HP:0010451)1.66464931
136Chronic hepatic failure (HP:0100626)1.66196339
137Duodenal stenosis (HP:0100867)1.66056397
138Small intestinal stenosis (HP:0012848)1.66056397
139Abnormality of vitamin metabolism (HP:0100508)1.65712908
140Abnormality of the common coagulation pathway (HP:0010990)1.65473258
141Neonatal hypoglycemia (HP:0001998)1.65316669
142Prominent metopic ridge (HP:0005487)1.65236388
143Transitional cell carcinoma of the bladder (HP:0006740)1.65223111
144Cafe-au-lait spot (HP:0000957)1.64695404
1453-Methylglutaconic aciduria (HP:0003535)1.64509556
146Lissencephaly (HP:0001339)1.64392358
147Pulmonary fibrosis (HP:0002206)1.64040142
148Medial flaring of the eyebrow (HP:0010747)1.63992872
149Abnormality of aromatic amino acid family metabolism (HP:0004338)1.63916464
150Hyperglycinemia (HP:0002154)1.63719927
151Recurrent abscess formation (HP:0002722)1.63190293
152Abnormality of monocarboxylic acid metabolism (HP:0010996)1.63126585
153Hypobetalipoproteinemia (HP:0003563)1.62540111
154Neoplasm of the adrenal cortex (HP:0100641)1.62262329
155Pancreatic fibrosis (HP:0100732)1.61626352
156Cystic hygroma (HP:0000476)1.61596285
157Abnormal drinking behavior (HP:0030082)1.61344877
158Polydipsia (HP:0001959)1.61344877
159Abnormality of endocrine pancreas physiology (HP:0012093)1.61273446
160Abnormality of the pancreatic islet cells (HP:0006476)1.61273446
161Asplenia (HP:0001746)1.60915348
162Lipid accumulation in hepatocytes (HP:0006561)1.60844723
163Prominent nose (HP:0000448)1.60657798
164Abnormality of the duodenum (HP:0002246)1.60348226
165Xanthomatosis (HP:0000991)1.60184647
166Abnormality of the renal medulla (HP:0100957)1.59731601
167Congenital hepatic fibrosis (HP:0002612)1.59410293
168Abnormal rod and cone electroretinograms (HP:0008323)1.58197211
169Absent thumb (HP:0009777)1.57102261
170Short tibia (HP:0005736)1.56639852
171Oculomotor apraxia (HP:0000657)1.56169566
172Pancreatic islet-cell hyperplasia (HP:0004510)1.56110264
173Increased CSF lactate (HP:0002490)1.55266849

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.79962460
2TAOK34.12014177
3STK38L3.81178677
4CDC73.53371576
5LATS23.28097064
6PLK43.22982868
7BMPR1B3.14468397
8MAP3K63.05027329
9ERBB42.96617149
10TXK2.79733775
11CDK122.76462726
12ZAK2.75445717
13EIF2AK32.57803513
14STK32.55823019
15PRKD32.32994285
16STK392.32854136
17WNK42.24750782
18NEK22.23461299
19MST42.19555304
20TLK12.17455584
21ADRBK22.14296288
22TTK2.09775660
23TAOK12.06116593
24TRIM282.02790908
25PNCK2.01785657
26BUB11.95285220
27STK161.95283541
28BRAF1.87842875
29KSR21.86312664
30MET1.81791617
31EEF2K1.77076962
32WNK31.73096589
33STK381.71841472
34GRK11.55151338
35ERBB31.52136334
36WEE11.51511608
37NLK1.49251477
38CDK91.48516986
39MAP3K91.48344138
40SIK31.48142771
41MAP3K131.46473009
42MARK31.43253689
43CHEK21.42147591
44MELK1.41980101
45MAP3K41.40244412
46TSSK61.36538738
47CDK81.27925829
48RAF11.24995259
49MUSK1.14829570
50NEK91.12082558
51PDK31.09979849
52PDK41.09979849
53SGK21.08357180
54OBSCN1.03967630
55MAP4K11.02138476
56JAK30.98885547
57NEK60.97309238
58MKNK20.96560686
59OXSR10.96529501
60KSR10.95190931
61MOS0.93803231
62NUAK10.93389224
63IRAK10.90880151
64PAK30.90409403
65MAP3K50.90090849
66INSRR0.87512036
67MAP2K40.86613949
68ACVR1B0.86157440
69PASK0.85554217
70EIF2AK10.85484932
71TNIK0.84052878
72PRKAA10.83732717
73PLK10.82308935
74ABL20.82255828
75PAK60.81976537
76SGK30.80659107
77PINK10.79321373
78CHEK10.78113567
79PRKAA20.78063663
80CAMK1D0.78037967
81ATM0.77314305
82CHUK0.76745610
83EIF2AK20.76156390
84MAP2K70.75250136
85BMPR20.75143879
86IKBKB0.73619688
87PRKCI0.72798786
88PHKG20.71827193
89PHKG10.71827193
90TYK20.71636763
91SRPK10.69707366
92TRPM70.68568802
93TRIB30.68006350
94TYRO30.67965674
95IRAK40.67403591
96ITK0.66668386
97CAMKK20.65353424
98RET0.63844510
99JAK20.62584127
100BRD40.61476428
101MAP3K100.61098348
102CDK40.61039735
103MAPK130.59606603
104MAPK110.58830064
105MST1R0.58749552
106STK240.58004599
107STK100.56765597
108PDK20.56359838
109DMPK0.55788159
110CDK60.55748707
111PRKD20.55503229
112ABL10.54677084
113PRKCQ0.54608531
114FRK0.52875816
115CAMK1G0.51771566
116ATR0.51259328
117FGFR20.51107811
118AURKB0.48619751
119CSNK1D0.48261809
120RPS6KA50.47194994
121MAP3K140.46403391
122JAK10.46387251
123PKN10.46128148
124CDK20.44458082
125PDGFRB0.43867028
126MAPKAPK30.42050302
127MAPK100.41117773
128MARK20.40938355
129MAP4K20.40466185
130PLK20.40191522
131MTOR0.39259930
132BRSK20.39152953
133CDK30.38528449
134CDK10.36493726
135SGK4940.36262551
136SGK2230.36262551
137IKBKE0.36204900
138AKT30.35567095
139WNK10.34972044
140TEC0.34758414
141STK40.34111691
142PDK10.33290719
143CSNK2A20.31690450
144MAPK140.31181634
145PIM10.31087354
146ARAF0.31042948
147RPS6KA40.30997149
148DYRK30.30912928
149BRSK10.30357142
150MAP3K80.30276747
151AKT10.29404826
152HIPK20.28551963
153CAMKK10.27458765
154PLK30.24771963
155FGFR30.24284825
156NTRK20.24176867
157GSK3B0.23391910

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.32162069
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.58100215
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.49557190
4Cell cycle_Homo sapiens_hsa041102.42448822
5Butanoate metabolism_Homo sapiens_hsa006502.32563083
6Primary immunodeficiency_Homo sapiens_hsa053402.29779454
7Staphylococcus aureus infection_Homo sapiens_hsa051502.19481540
8Complement and coagulation cascades_Homo sapiens_hsa046102.10958525
9Dorso-ventral axis formation_Homo sapiens_hsa043202.07967669
10Basal transcription factors_Homo sapiens_hsa030222.00798963
11Mismatch repair_Homo sapiens_hsa034301.93403771
12Vitamin B6 metabolism_Homo sapiens_hsa007501.91743911
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.91488907
14Ovarian steroidogenesis_Homo sapiens_hsa049131.89608180
15Pancreatic cancer_Homo sapiens_hsa052121.86942358
16RNA degradation_Homo sapiens_hsa030181.80506297
17Protein export_Homo sapiens_hsa030601.78589045
18Lysine degradation_Homo sapiens_hsa003101.78521080
19Phototransduction_Homo sapiens_hsa047441.73630392
20RNA polymerase_Homo sapiens_hsa030201.73225186
21DNA replication_Homo sapiens_hsa030301.73051287
22Circadian rhythm_Homo sapiens_hsa047101.70877949
23Folate biosynthesis_Homo sapiens_hsa007901.70527496
24Arginine biosynthesis_Homo sapiens_hsa002201.67543527
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.65661637
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.63864248
27Fanconi anemia pathway_Homo sapiens_hsa034601.60724454
28Prolactin signaling pathway_Homo sapiens_hsa049171.55848730
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.54260674
30Selenocompound metabolism_Homo sapiens_hsa004501.54086538
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53081285
32Nitrogen metabolism_Homo sapiens_hsa009101.51219466
33Nucleotide excision repair_Homo sapiens_hsa034201.50983655
34Homologous recombination_Homo sapiens_hsa034401.50191143
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.48989028
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.46079312
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.45309348
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.40195574
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38874155
40Propanoate metabolism_Homo sapiens_hsa006401.36969590
41Regulation of autophagy_Homo sapiens_hsa041401.32646013
42p53 signaling pathway_Homo sapiens_hsa041151.27959694
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25600040
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25392095
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19023031
46Proteasome_Homo sapiens_hsa030501.18085486
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15781796
48Oocyte meiosis_Homo sapiens_hsa041141.13764831
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09597522
50mTOR signaling pathway_Homo sapiens_hsa041501.09022687
51Linoleic acid metabolism_Homo sapiens_hsa005911.08978557
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.07821021
53T cell receptor signaling pathway_Homo sapiens_hsa046601.06719921
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.06045602
55Pyrimidine metabolism_Homo sapiens_hsa002401.05114208
56Spliceosome_Homo sapiens_hsa030401.02452404
57Type I diabetes mellitus_Homo sapiens_hsa049401.01755682
58Herpes simplex infection_Homo sapiens_hsa051681.00913122
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99463202
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98742227
61TGF-beta signaling pathway_Homo sapiens_hsa043500.98111445
62Tryptophan metabolism_Homo sapiens_hsa003800.96935790
63Caffeine metabolism_Homo sapiens_hsa002320.96355510
64MicroRNAs in cancer_Homo sapiens_hsa052060.96073631
65Influenza A_Homo sapiens_hsa051640.95286128
66FoxO signaling pathway_Homo sapiens_hsa040680.91741914
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89808571
68Chronic myeloid leukemia_Homo sapiens_hsa052200.89053393
69Hepatitis B_Homo sapiens_hsa051610.87701807
70Fatty acid elongation_Homo sapiens_hsa000620.85846219
71Non-small cell lung cancer_Homo sapiens_hsa052230.85501091
72Type II diabetes mellitus_Homo sapiens_hsa049300.85008337
73Other glycan degradation_Homo sapiens_hsa005110.84025910
74Colorectal cancer_Homo sapiens_hsa052100.83049781
75Purine metabolism_Homo sapiens_hsa002300.82547679
76Endometrial cancer_Homo sapiens_hsa052130.81684839
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79955324
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78155284
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77880355
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.77112955
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76986256
82PPAR signaling pathway_Homo sapiens_hsa033200.75861139
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74923542
84Non-homologous end-joining_Homo sapiens_hsa034500.73605971
85Choline metabolism in cancer_Homo sapiens_hsa052310.72985517
86Osteoclast differentiation_Homo sapiens_hsa043800.71565324
87Fatty acid metabolism_Homo sapiens_hsa012120.71316290
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.70167667
89ABC transporters_Homo sapiens_hsa020100.69824031
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68115072
91Glucagon signaling pathway_Homo sapiens_hsa049220.67629601
92Insulin resistance_Homo sapiens_hsa049310.66838996
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.66498720
94Chemical carcinogenesis_Homo sapiens_hsa052040.64938791
95B cell receptor signaling pathway_Homo sapiens_hsa046620.63918115
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62814601
97RNA transport_Homo sapiens_hsa030130.62628547
98TNF signaling pathway_Homo sapiens_hsa046680.62266607
99GnRH signaling pathway_Homo sapiens_hsa049120.60520242
100Prostate cancer_Homo sapiens_hsa052150.59531545
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59154189
102Leishmaniasis_Homo sapiens_hsa051400.59043016
103RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58900051
104Toxoplasmosis_Homo sapiens_hsa051450.58842502
105mRNA surveillance pathway_Homo sapiens_hsa030150.58788258
106Pentose phosphate pathway_Homo sapiens_hsa000300.58590543
107VEGF signaling pathway_Homo sapiens_hsa043700.58587326
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.57727896
109Small cell lung cancer_Homo sapiens_hsa052220.55735599
110One carbon pool by folate_Homo sapiens_hsa006700.55466290
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55313869
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54405167
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54251347
114Fatty acid degradation_Homo sapiens_hsa000710.53860677
115Renal cell carcinoma_Homo sapiens_hsa052110.53451836
116Adherens junction_Homo sapiens_hsa045200.51681956
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51537456
118Base excision repair_Homo sapiens_hsa034100.50919415
119Measles_Homo sapiens_hsa051620.50534493
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.49935908
121Notch signaling pathway_Homo sapiens_hsa043300.49897797
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.49150126
123Glycerolipid metabolism_Homo sapiens_hsa005610.48457456
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.48430657
125Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48029473
126Tuberculosis_Homo sapiens_hsa051520.47520939
127Oxidative phosphorylation_Homo sapiens_hsa001900.46369066
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.46283333
129Retinol metabolism_Homo sapiens_hsa008300.46036919
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45315700
131Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45242289
132Bile secretion_Homo sapiens_hsa049760.44638675
133Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43777926
134Epstein-Barr virus infection_Homo sapiens_hsa051690.43678287
135Ether lipid metabolism_Homo sapiens_hsa005650.42977894
136Metabolic pathways_Homo sapiens_hsa011000.42021353
137Inositol phosphate metabolism_Homo sapiens_hsa005620.41863849
138Steroid biosynthesis_Homo sapiens_hsa001000.41660939
139beta-Alanine metabolism_Homo sapiens_hsa004100.41353653
140Hematopoietic cell lineage_Homo sapiens_hsa046400.41310299
141Glioma_Homo sapiens_hsa052140.41133548
142HTLV-I infection_Homo sapiens_hsa051660.40657146
143Estrogen signaling pathway_Homo sapiens_hsa049150.40361833
144Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40097646
145Peroxisome_Homo sapiens_hsa041460.39936560
146Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39713110
147Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39527063
148Autoimmune thyroid disease_Homo sapiens_hsa053200.39075328
149Viral carcinogenesis_Homo sapiens_hsa052030.36188094
150Fatty acid biosynthesis_Homo sapiens_hsa000610.35820302
151Arachidonic acid metabolism_Homo sapiens_hsa005900.34683733
152Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34663092
153Olfactory transduction_Homo sapiens_hsa047400.34529627
154Antigen processing and presentation_Homo sapiens_hsa046120.31705769
155Sphingolipid metabolism_Homo sapiens_hsa006000.31517995
156Fat digestion and absorption_Homo sapiens_hsa049750.28891944
157Allograft rejection_Homo sapiens_hsa053300.26953360

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