SFMBT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.40543492
2nuclear pore organization (GO:0006999)6.03760681
3positive regulation of gamma-delta T cell activation (GO:0046645)5.94427266
4histone H4-K12 acetylation (GO:0043983)5.81466476
5protein localization to kinetochore (GO:0034501)5.21935169
6heterochromatin organization (GO:0070828)5.19925352
7DNA replication-dependent nucleosome organization (GO:0034723)5.07851658
8DNA replication-dependent nucleosome assembly (GO:0006335)5.07851658
9regulation of gene silencing by RNA (GO:0060966)4.96828700
10regulation of posttranscriptional gene silencing (GO:0060147)4.96828700
11regulation of gene silencing by miRNA (GO:0060964)4.96828700
12pre-miRNA processing (GO:0031054)4.96794077
13pore complex assembly (GO:0046931)4.80973351
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.80969768
15regulation of telomere maintenance via telomerase (GO:0032210)4.79517628
16daunorubicin metabolic process (GO:0044597)4.74814354
17polyketide metabolic process (GO:0030638)4.74814354
18doxorubicin metabolic process (GO:0044598)4.74814354
19histone H4-K5 acetylation (GO:0043981)4.74591707
20histone H4-K8 acetylation (GO:0043982)4.74591707
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.74255500
22mitotic sister chromatid segregation (GO:0000070)4.61147098
23regulation of nuclear cell cycle DNA replication (GO:0033262)4.60412913
24regulation of B cell receptor signaling pathway (GO:0050855)4.60361458
25trophectodermal cell differentiation (GO:0001829)4.58951427
26regulation of gamma-delta T cell activation (GO:0046643)4.58785699
27antigen processing and presentation of endogenous antigen (GO:0019883)4.54997921
28positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.48179926
29negative thymic T cell selection (GO:0045060)4.33460783
30negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.32611536
31positive T cell selection (GO:0043368)4.32013946
32piRNA metabolic process (GO:0034587)4.31633511
33negative T cell selection (GO:0043383)4.26241967
34positive thymic T cell selection (GO:0045059)4.25776143
35B cell receptor signaling pathway (GO:0050853)4.24033235
36regulation of gamma-delta T cell differentiation (GO:0045586)4.23337810
37protein localization to chromosome, centromeric region (GO:0071459)4.21625118
38DNA replication checkpoint (GO:0000076)4.21376662
39modulation by symbiont of host immune response (GO:0052553)4.17754124
40positive regulation by symbiont of host defense response (GO:0052509)4.17754124
41modulation by symbiont of host defense response (GO:0052031)4.17754124
42modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.17754124
43modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.17754124
44positive regulation by organism of defense response of other organism involved in symbiotic interact4.17754124
45chromatin assembly (GO:0031497)4.12291980
46negative regulation of epidermis development (GO:0045683)4.10747955
47negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.09472462
48negative regulation of cell killing (GO:0031342)4.08705754
49negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.08705754
50sister chromatid segregation (GO:0000819)4.05305974
51positive regulation of B cell differentiation (GO:0045579)4.01000063
52T cell migration (GO:0072678)3.95378472
53T cell selection (GO:0045058)3.85990792
54macrophage activation involved in immune response (GO:0002281)3.83867192
55negative regulation of cell cycle G2/M phase transition (GO:1902750)3.83450793
56activated T cell proliferation (GO:0050798)3.81431631
57positive regulation of granulocyte differentiation (GO:0030854)3.76059809
58response to muramyl dipeptide (GO:0032495)3.75643874
59negative regulation of telomerase activity (GO:0051974)3.71983597
60mitotic nuclear envelope disassembly (GO:0007077)3.70954697
61thymic T cell selection (GO:0045061)3.70880512
62positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.68511742
63maintenance of protein location in nucleus (GO:0051457)3.67116558
64cellular extravasation (GO:0045123)3.66741489
65regulation of mammary gland epithelial cell proliferation (GO:0033599)3.66066424
66histone H3-K36 demethylation (GO:0070544)3.65410223
67histone H4-K16 acetylation (GO:0043984)3.61535389
68DNA duplex unwinding (GO:0032508)3.57933849
69mitotic chromosome condensation (GO:0007076)3.57048132
70DNA geometric change (GO:0032392)3.56620859
71positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.53657056
72histone H2A monoubiquitination (GO:0035518)3.53363423
73formation of translation preinitiation complex (GO:0001731)3.52083327
74interferon-gamma production (GO:0032609)3.51858437
75negative regulation of interleukin-12 production (GO:0032695)3.49403217
76antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.48958068
77synaptonemal complex assembly (GO:0007130)3.48442354
78regulation of B cell differentiation (GO:0045577)3.48048177
79DNA unwinding involved in DNA replication (GO:0006268)3.46808892
80ribosome biogenesis (GO:0042254)3.46015357
81membrane disassembly (GO:0030397)3.44896248
82nuclear envelope disassembly (GO:0051081)3.44896248
83immunoglobulin mediated immune response (GO:0016064)3.44578482
84regulation of cilium movement (GO:0003352)3.44133726
85response to peptidoglycan (GO:0032494)3.43313408
86somite rostral/caudal axis specification (GO:0032525)3.41288715
87DNA replication initiation (GO:0006270)3.41103189
88regulation of interleukin-2 biosynthetic process (GO:0045076)3.40441965
89negative regulation of histone methylation (GO:0031061)3.39830985
90negative regulation of erythrocyte differentiation (GO:0045647)3.38253439
91positive regulation of antigen processing and presentation (GO:0002579)3.36401637
92cellular response to ethanol (GO:0071361)3.35884049
93positive regulation of DNA-dependent DNA replication (GO:2000105)3.35046360
94germinal center formation (GO:0002467)3.33387949
95regulation of histone H3-K9 methylation (GO:0051570)3.33044319
96detection of other organism (GO:0098543)3.31726856
97notochord development (GO:0030903)3.31081955
98regulation of response to osmotic stress (GO:0047484)3.31053779
99mannose metabolic process (GO:0006013)3.29073028
100B cell homeostasis (GO:0001782)3.28758369
101rRNA transcription (GO:0009303)3.26278811
102positive regulation of interleukin-2 production (GO:0032743)3.25657297
103NLS-bearing protein import into nucleus (GO:0006607)3.25264870
104microglial cell activation (GO:0001774)3.24135282
105regulation of alpha-beta T cell proliferation (GO:0046640)3.22833742
106response to type I interferon (GO:0034340)3.21473233
107detection of bacterium (GO:0016045)3.21031666
108cellular response to type I interferon (GO:0071357)3.20365996
109type I interferon signaling pathway (GO:0060337)3.20365996
110response to interleukin-15 (GO:0070672)3.16220402
111interferon-gamma-mediated signaling pathway (GO:0060333)3.14856476
112synaptonemal complex organization (GO:0070193)3.14522705
113regulation of granulocyte differentiation (GO:0030852)3.13797183
114negative regulation of T cell mediated immunity (GO:0002710)3.11859814
115gene silencing by RNA (GO:0031047)3.11850273
116branching involved in labyrinthine layer morphogenesis (GO:0060670)3.11154115
117regulation of double-strand break repair (GO:2000779)3.11019422
118negative regulation of bone resorption (GO:0045779)3.10579350
119DNA methylation involved in gamete generation (GO:0043046)3.09908959
120regulation of gene silencing (GO:0060968)3.09562519
121regulation of translation in response to stress (GO:0043555)3.08417457
122paraxial mesoderm development (GO:0048339)3.07995974
123RNA stabilization (GO:0043489)3.06858697
124mRNA stabilization (GO:0048255)3.06858697
125tolerance induction (GO:0002507)3.06480006
126regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.04983149
127myeloid cell activation involved in immune response (GO:0002275)3.04672354
128regulation of dendritic cell antigen processing and presentation (GO:0002604)3.04322621
129male meiosis (GO:0007140)3.04106406
130regulation of hippo signaling (GO:0035330)3.03553306
131response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.03522433
132response to host immune response (GO:0052572)3.03522433
133regulation of type I interferon-mediated signaling pathway (GO:0060338)3.00071662
134positive regulation of alpha-beta T cell proliferation (GO:0046641)2.99221429
135phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.97717878
136muscle organ morphogenesis (GO:0048644)2.97492061
137DNA conformation change (GO:0071103)2.97457488
138positive regulation of interferon-alpha production (GO:0032727)2.97361752
139defense response to protozoan (GO:0042832)2.97037496
140detection of external biotic stimulus (GO:0098581)2.96983882
141antigen receptor-mediated signaling pathway (GO:0050851)2.96612971
142mast cell activation (GO:0045576)2.96585270
143natural killer cell differentiation (GO:0001779)2.96054731
144detection of molecule of bacterial origin (GO:0032490)2.95006009
145regulation of interferon-beta biosynthetic process (GO:0045357)2.94935944
146chromatin assembly or disassembly (GO:0006333)2.93853067
147regulation of telomere maintenance (GO:0032204)2.93666055
148histone H3-K4 trimethylation (GO:0080182)2.93633998
149CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.93549932
150rRNA modification (GO:0000154)2.93478019
151rRNA methylation (GO:0031167)2.92584582
152macrophage activation (GO:0042116)2.92541383
153folic acid-containing compound biosynthetic process (GO:0009396)2.92153689
154regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.90724619
155cell differentiation involved in embryonic placenta development (GO:0060706)2.88483542
156protein K6-linked ubiquitination (GO:0085020)2.88397946
157protein localization to chromosome (GO:0034502)2.88067057
158negative regulation of telomere maintenance (GO:0032205)2.87978948
159interferon-gamma secretion (GO:0072643)2.87457343
160mitotic metaphase plate congression (GO:0007080)2.87160943
161aminoglycoside antibiotic metabolic process (GO:0030647)2.85664147
162nucleobase biosynthetic process (GO:0046112)2.84629610
163chromosome condensation (GO:0030261)2.84118950
164leukocyte aggregation (GO:0070486)2.83834386
165regulation of interleukin-12 biosynthetic process (GO:0045075)2.83704107
166spindle assembly (GO:0051225)2.83465136
167response to protozoan (GO:0001562)2.83275063
168mitotic sister chromatid cohesion (GO:0007064)2.82837039
169respiratory burst (GO:0045730)2.81780375
170regulation of antigen processing and presentation (GO:0002577)2.81397670
171cell fate commitment involved in formation of primary germ layer (GO:0060795)2.80527698
172B cell mediated immunity (GO:0019724)2.80397352
173regulation of interferon-alpha production (GO:0032647)2.80131268
174regulation of DNA-dependent DNA replication (GO:0090329)2.79791034
175response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.78818349
176response to host (GO:0075136)2.78818349
177response to host defenses (GO:0052200)2.78818349
178detection of biotic stimulus (GO:0009595)2.77598070
179antigen processing and presentation via MHC class Ib (GO:0002475)2.77298470
180attachment of spindle microtubules to kinetochore (GO:0008608)2.76802734
181cellular response to interleukin-15 (GO:0071350)2.76450803
182chromosome organization involved in meiosis (GO:0070192)2.75510949
183placenta development (GO:0001890)2.74583542
184T cell proliferation (GO:0042098)2.73796550
185negative regulation of lymphocyte mediated immunity (GO:0002707)2.73655344
186regulation of MHC class I biosynthetic process (GO:0045343)2.73102006
187regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.72985402
188negative regulation of epidermal cell differentiation (GO:0045605)2.72729576
189negative regulation of gene silencing (GO:0060969)2.72180117
190somatic hypermutation of immunoglobulin genes (GO:0016446)2.70938134
191somatic diversification of immune receptors via somatic mutation (GO:0002566)2.70938134
192regulation of hypersensitivity (GO:0002883)2.70883403
193monoubiquitinated protein deubiquitination (GO:0035520)2.70695728
194mitotic G2/M transition checkpoint (GO:0044818)2.70496183
195DNA packaging (GO:0006323)2.70481017
196intestinal epithelial cell development (GO:0060576)2.70064646
197myeloid dendritic cell activation (GO:0001773)2.69944974
198T cell costimulation (GO:0031295)2.68515079
199regulation of interleukin-2 production (GO:0032663)2.66182372
200regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.65673588

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.38968170
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.69927577
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.29820246
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.29820246
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.29820246
6* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.12607402
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.32146199
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.06047398
9SCL_19346495_ChIP-Seq_HPC-7_Human3.65653899
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.57189813
11IRF8_21731497_ChIP-ChIP_J774_Mouse3.55031909
12FOXM1_23109430_ChIP-Seq_U2OS_Human3.48288157
13E2F4_17652178_ChIP-ChIP_JURKAT_Human3.47151980
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.39791128
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.26766269
16RUNX_20019798_ChIP-Seq_JUKART_Human3.24845591
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.18287089
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human3.06265338
19MYC_18555785_ChIP-Seq_MESCs_Mouse3.01001646
20MYB_26560356_Chip-Seq_TH2_Human2.96028251
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.93505117
22SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.93235665
23* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.92695593
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.89648652
25* IRF8_27001747_Chip-Seq_BMDM_Mouse2.87138917
26NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.83534821
27VDR_21846776_ChIP-Seq_THP-1_Human2.82709227
28TP63_19390658_ChIP-ChIP_HaCaT_Human2.78782913
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.64678164
30VDR_24763502_ChIP-Seq_THP-1_Human2.55755307
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.55066973
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.52841816
33GATA1_22025678_ChIP-Seq_K562_Human2.51030380
34* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.48424425
35MYB_21317192_ChIP-Seq_ERMYB_Mouse2.46632527
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.43505801
37* MYB_26560356_Chip-Seq_TH1_Human2.41220965
38MAF_26560356_Chip-Seq_TH1_Human2.37041771
39* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.36073502
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.34882287
41STAT4_19710469_ChIP-ChIP_TH1__Mouse2.32641950
42NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.31309560
43MYC_19030024_ChIP-ChIP_MESCs_Mouse2.23724556
44SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.20977473
45TCF3_18692474_ChIP-Seq_MESCs_Mouse2.20129693
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.16147498
47SPI1_23127762_ChIP-Seq_K562_Human2.16061047
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.15357092
49TCF3_18692474_ChIP-Seq_MEFs_Mouse2.13853037
50SPI1_23547873_ChIP-Seq_NB4_Human2.10249010
51RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05967109
52ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.02148088
53* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00141061
54STAT3_1855785_ChIP-Seq_MESCs_Mouse1.99147178
55GATA3_27048872_Chip-Seq_THYMUS_Human1.97526666
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.96828925
57* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.94268657
58* VDR_24787735_ChIP-Seq_THP-1_Human1.93803045
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90070099
60BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87469992
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.86888726
62UTX_26944678_Chip-Seq_JUKART_Human1.86565755
63ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.86058471
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.84536030
65CIITA_25753668_ChIP-Seq_RAJI_Human1.83107953
66EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.82837693
67AR_21909140_ChIP-Seq_LNCAP_Human1.80790607
68* MAF_26560356_Chip-Seq_TH2_Human1.80227393
69FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.80182053
70MYC_18358816_ChIP-ChIP_MESCs_Mouse1.79434597
71TCF7_22412390_ChIP-Seq_EML_Mouse1.79201646
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.79201420
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.78916782
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.77917526
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.76245365
76NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.73460992
77NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.73454265
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.73008829
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.72094852
80EGR1_19374776_ChIP-ChIP_THP-1_Human1.72054190
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68623682
82BP1_19119308_ChIP-ChIP_Hs578T_Human1.66118416
83SOX2_18555785_ChIP-Seq_MESCs_Mouse1.65972780
84NELFA_20434984_ChIP-Seq_ESCs_Mouse1.64634626
85SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.63151828
86* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.61577527
87HIF1A_21447827_ChIP-Seq_MCF-7_Human1.61238823
88RUNX1_22412390_ChIP-Seq_EML_Mouse1.60644383
89* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.59643127
90* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56387057
91POU5F1_16518401_ChIP-PET_MESCs_Mouse1.56299647
92MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54029990
93RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.50872056
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49735241
95GATA3_26560356_Chip-Seq_TH2_Human1.49625020
96* KDM2B_26808549_Chip-Seq_DND41_Human1.48976169
97* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48529658
98CREB1_15753290_ChIP-ChIP_HEK293T_Human1.46417593
99ESR1_15608294_ChIP-ChIP_MCF-7_Human1.41631193
100ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40247578
101TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.39090803
102* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.38783197
103PU_27001747_Chip-Seq_BMDM_Mouse1.38509113
104EST1_17652178_ChIP-ChIP_JURKAT_Human1.37363238
105PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37348432
106XRN2_22483619_ChIP-Seq_HELA_Human1.35587484
107E2F1_21310950_ChIP-Seq_MCF-7_Human1.35025037
108NANOG_18692474_ChIP-Seq_MESCs_Mouse1.33278519
109PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27845345
110POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.27838095
111SOX2_18692474_ChIP-Seq_MESCs_Mouse1.27027818
112GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26975583
113SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26700140
114GATA1_19941827_ChIP-Seq_MEL_Mouse1.26607067
115NANOG_18692474_ChIP-Seq_MEFs_Mouse1.26568323
116YY1_21170310_ChIP-Seq_MESCs_Mouse1.26502132
117PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.25999649
118TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25865489
119MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25296717
120KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24652167
121MYC_22102868_ChIP-Seq_BL_Human1.24650226
122GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23955380
123KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.21039652
124RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.20608935
125* NANOG_21062744_ChIP-ChIP_HESCs_Human1.18380586
126GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18153608
127E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18052955
128RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15797078
129CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13645923
130OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12216335
131ETS1_20019798_ChIP-Seq_JURKAT_Human1.11823943
132* NANOG_16518401_ChIP-PET_MESCs_Mouse1.11761721
133GATA1_19941826_ChIP-Seq_K562_Human1.11108198
134KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08840702
135SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08679684
136SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08129807
137* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07855493
138* KDM2B_26808549_Chip-Seq_JURKAT_Human1.07710072
139FOXP3_21729870_ChIP-Seq_TREG_Human1.07607084
140KDM5A_27292631_Chip-Seq_BREAST_Human1.07557983
141TTF2_22483619_ChIP-Seq_HELA_Human1.05581061
142SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04751882
143POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.04403405
144ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02606637
145NANOG_16153702_ChIP-ChIP_HESCs_Human1.02271110
146* SMRT_27268052_Chip-Seq_Bcells_Human1.01439845
147JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.00283689
148IRF1_19129219_ChIP-ChIP_H3396_Human0.99877376
149ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99423591
150YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98856450
151FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98784967
152ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96867943
153PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95825251
154VDR_23849224_ChIP-Seq_CD4+_Human0.94792703
155ETS1_22383799_ChIP-Seq_G1ME_Mouse0.93562944
156* PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93556736
157GABP_19822575_ChIP-Seq_HepG2_Human0.93033069
158MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92003142
159* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.91438060
160KAP1_27257070_Chip-Seq_ESCs_Mouse0.91264134
161CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90813895
162LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89403148
163CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87609174
164SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87486913
165DCP1A_22483619_ChIP-Seq_HELA_Human0.87469223
166* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85761739
167GABP_17652178_ChIP-ChIP_JURKAT_Human0.84973031
168* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84597436
169CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83480914
170GATA1_26923725_Chip-Seq_HPCs_Mouse0.82187231
171SOX2_16153702_ChIP-ChIP_HESCs_Human0.82100077
172E2F1_17053090_ChIP-ChIP_MCF-7_Human0.82035225
173POU5F1_16153702_ChIP-ChIP_HESCs_Human0.81862541
174* GATA2_19941826_ChIP-Seq_K562_Human0.81606869
175* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.81528137
176RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80852400
177CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78894792
178* DROSHA_22980978_ChIP-Seq_HELA_Human0.78623665
179GATA1_19941827_ChIP-Seq_MEL86_Mouse0.78424278
180VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.77581842
181TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.76753981
182NCOR1_26117541_ChIP-Seq_K562_Human0.76464148
183GATA1_22383799_ChIP-Seq_G1ME_Mouse0.75214973
184PU.1_20513432_ChIP-Seq_Bcells_Mouse0.74201971
185PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73853899
186TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73394888
187GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73022038
188TFEB_21752829_ChIP-Seq_HELA_Human0.71772338
189GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.70380502
190CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.69672584
191FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69463600
192PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.68768134
193LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.68733758
194BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.67977639
195ERG_20887958_ChIP-Seq_HPC-7_Mouse0.64960706

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.26198659
2MP0004264_abnormal_extraembryonic_tissu4.16460966
3MP0003763_abnormal_thymus_physiology3.61048978
4MP0004957_abnormal_blastocyst_morpholog3.58630535
5MP0008057_abnormal_DNA_replication3.50811391
6MP0005671_abnormal_response_to3.39960599
7MP0003123_paternal_imprinting3.30093748
8MP0001800_abnormal_humoral_immune3.19315373
9MP0003121_genomic_imprinting3.06905328
10MP0003436_decreased_susceptibility_to3.00654080
11MP0003890_abnormal_embryonic-extraembry2.89982734
12MP0001790_abnormal_immune_system2.88974091
13MP0005387_immune_system_phenotype2.88974091
14MP0003303_peritoneal_inflammation2.85507501
15MP0005000_abnormal_immune_tolerance2.81561527
16MP0003111_abnormal_nucleus_morphology2.71264417
17MP0010094_abnormal_chromosome_stability2.69705790
18MP0000685_abnormal_immune_system2.67863740
19MP0003705_abnormal_hypodermis_morpholog2.67660968
20MP0010352_gastrointestinal_tract_polyps2.66944274
21MP0002723_abnormal_immune_serum2.64844115
22MP0003693_abnormal_embryo_hatching2.59614001
23MP0003122_maternal_imprinting2.58284584
24MP0003077_abnormal_cell_cycle2.58116228
25MP0002452_abnormal_antigen_presenting2.56895143
26MP0008877_abnormal_DNA_methylation2.52045811
27MP0002420_abnormal_adaptive_immunity2.50518535
28MP0002653_abnormal_ependyma_morphology2.48465650
29MP0001819_abnormal_immune_cell2.46253758
30MP0002419_abnormal_innate_immunity2.45735147
31MP0002009_preneoplasia2.43426940
32MP0003300_gastrointestinal_ulcer2.36079885
33MP0006292_abnormal_olfactory_placode2.32519830
34MP0005025_abnormal_response_to2.31363761
35MP0005380_embryogenesis_phenotype2.29422482
36MP0001672_abnormal_embryogenesis/_devel2.29422482
37MP0002398_abnormal_bone_marrow2.27892845
38MP0003724_increased_susceptibility_to2.26448333
39MP0000569_abnormal_digit_pigmentation2.21306244
40MP0003011_delayed_dark_adaptation2.20539904
41MP0002166_altered_tumor_susceptibility2.17961860
42MP0003984_embryonic_growth_retardation2.13464633
43MP0002088_abnormal_embryonic_growth/wei2.11805264
44MP0002086_abnormal_extraembryonic_tissu2.11735210
45MP0000716_abnormal_immune_system2.07665349
46MP0002254_reproductive_system_inflammat2.05771296
47MP0002148_abnormal_hypersensitivity_rea2.02575291
48MP0001730_embryonic_growth_arrest2.02439514
49MP0006082_CNS_inflammation1.99485587
50MP0000350_abnormal_cell_proliferation1.98597033
51MP0009785_altered_susceptibility_to1.98539779
52MP0000703_abnormal_thymus_morphology1.94019048
53MP0004197_abnormal_fetal_growth/weight/1.93190378
54MP0002084_abnormal_developmental_patter1.90225234
55MP0000689_abnormal_spleen_morphology1.88810945
56MP0001873_stomach_inflammation1.86671283
57MP0002405_respiratory_system_inflammati1.84821286
58MP0004808_abnormal_hematopoietic_stem1.83845991
59MP0009278_abnormal_bone_marrow1.83065207
60MP0009333_abnormal_splenocyte_physiolog1.79730086
61MP0002085_abnormal_embryonic_tissue1.79274413
62MP0001293_anophthalmia1.75142691
63MP0001697_abnormal_embryo_size1.73645462
64MP0003172_abnormal_lysosome_physiology1.72923128
65MP0005310_abnormal_salivary_gland1.72822225
66MP0008932_abnormal_embryonic_tissue1.72734284
67MP0002722_abnormal_immune_system1.70529490
68MP0008058_abnormal_DNA_repair1.68923452
69MP0002429_abnormal_blood_cell1.66755384
70MP0008007_abnormal_cellular_replicative1.66581253
71MP0005410_abnormal_fertilization1.65683371
72MP0002006_tumorigenesis1.59657549
73MP0005623_abnormal_meninges_morphology1.59342333
74MP0004858_abnormal_nervous_system1.54974910
75MP0005464_abnormal_platelet_physiology1.53581246
76MP0004133_heterotaxia1.53328422
77MP0005397_hematopoietic_system_phenotyp1.52202721
78MP0001545_abnormal_hematopoietic_system1.52202721
79MP0003119_abnormal_digestive_system1.50762651
80MP0010155_abnormal_intestine_physiology1.50521379
81MP0002210_abnormal_sex_determination1.48649525
82MP0003786_premature_aging1.48566723
83MP0001845_abnormal_inflammatory_respons1.48174145
84MP0005499_abnormal_olfactory_system1.46153422
85MP0005394_taste/olfaction_phenotype1.46153422
86MP0004381_abnormal_hair_follicle1.43854810
87MP0002080_prenatal_lethality1.43115814
88MP0001145_abnormal_male_reproductive1.43072536
89MP0001929_abnormal_gametogenesis1.42658937
90MP0001853_heart_inflammation1.40867088
91MP0004947_skin_inflammation1.40235921
92MP0005075_abnormal_melanosome_morpholog1.35356820
93MP0002127_abnormal_cardiovascular_syste1.33124668
94MP0002998_abnormal_bone_remodeling1.32538196
95MP0005257_abnormal_intraocular_pressure1.30975986
96MP0002332_abnormal_exercise_endurance1.29715253
97MP0004272_abnormal_basement_membrane1.29515054
98MP0005076_abnormal_cell_differentiation1.29491873
99MP0003866_abnormal_defecation1.27749179
100MP0003787_abnormal_imprinting1.26838490
101MP0003566_abnormal_cell_adhesion1.26409956
102MP0010307_abnormal_tumor_latency1.25785858
103MP0001533_abnormal_skeleton_physiology1.21871641
104MP0000015_abnormal_ear_pigmentation1.20636465
105MP0002092_abnormal_eye_morphology1.19919063
106MP0000428_abnormal_craniofacial_morphol1.19548217
107MP0003698_abnormal_male_reproductive1.19026743
108MP0003567_abnormal_fetal_cardiomyocyte1.15894277
109MP0003937_abnormal_limbs/digits/tail_de1.14031627
110MP0005023_abnormal_wound_healing1.12412184
111MP0001849_ear_inflammation1.11027921
112MP0003315_abnormal_perineum_morphology1.10923549
113MP0000653_abnormal_sex_gland1.06479430
114MP0005451_abnormal_body_composition1.05957788
115MP0009703_decreased_birth_body1.05531218
116MP0003938_abnormal_ear_development1.05423663
117MP0005174_abnormal_tail_pigmentation1.05312764
118MP0006035_abnormal_mitochondrial_morpho1.04530203
119MP0000432_abnormal_head_morphology1.04426402
120MP0000313_abnormal_cell_death1.04370883
121MP0003045_fibrosis1.03181239
122MP0003690_abnormal_glial_cell1.02199779
123MP0002925_abnormal_cardiovascular_devel1.00569711
124MP0008469_abnormal_protein_level0.99589001
125MP0003941_abnormal_skin_development0.95342976
126MP0000604_amyloidosis0.92553701
127MP0002396_abnormal_hematopoietic_system0.91587940
128MP0005058_abnormal_lysosome_morphology0.91447638
129MP0010030_abnormal_orbit_morphology0.91414445
130MP0003935_abnormal_craniofacial_develop0.90538014
131MP0003755_abnormal_palate_morphology0.89617442
132MP0002160_abnormal_reproductive_system0.89364594
133MP0003861_abnormal_nervous_system0.89331166
134MP0000465_gastrointestinal_hemorrhage0.88477136
135MP0005266_abnormal_metabolism0.88092734
136MP0009764_decreased_sensitivity_to0.87968837
137MP0000490_abnormal_crypts_of0.87088671
138MP0001851_eye_inflammation0.86600595
139MP0002114_abnormal_axial_skeleton0.86213544
140MP0009115_abnormal_fat_cell0.84566493
141MP0000858_altered_metastatic_potential0.84505452
142MP0000371_diluted_coat_color0.84093493
143MP0004883_abnormal_blood_vessel0.83583159
144MP0002111_abnormal_tail_morphology0.83568364
145MP0001286_abnormal_eye_development0.82088858
146MP0002697_abnormal_eye_size0.81944759
147MP0005167_abnormal_blood-brain_barrier0.79817971
148MP0003828_pulmonary_edema0.79475917
149MP0003656_abnormal_erythrocyte_physiolo0.79060767
150MP0005384_cellular_phenotype0.78462977
151MP0002233_abnormal_nose_morphology0.77619405
152MP0008770_decreased_survivor_rate0.77395167
153MP0003646_muscle_fatigue0.76390909
154MP0000762_abnormal_tongue_morphology0.76230674
155MP0001915_intracranial_hemorrhage0.75212734
156MP0000358_abnormal_cell_content/0.74943400
157MP0002161_abnormal_fertility/fecundity0.74795795
158MP0005647_abnormal_sex_gland0.73847550
159MP0002932_abnormal_joint_morphology0.73400867
160MP0002019_abnormal_tumor_incidence0.73207594
161MP0002277_abnormal_respiratory_mucosa0.71947107
162MP0000049_abnormal_middle_ear0.68571802
163MP0002693_abnormal_pancreas_physiology0.68014320
164MP0000678_abnormal_parathyroid_gland0.67405503
165MP0009672_abnormal_birth_weight0.67297928
166MP0005391_vision/eye_phenotype0.67145241
167MP0003936_abnormal_reproductive_system0.67071044
168MP0004130_abnormal_muscle_cell0.66156484
169MP0003221_abnormal_cardiomyocyte_apopto0.65763944
170MP0002933_joint_inflammation0.65679196
171MP0001501_abnormal_sleep_pattern0.64099512
172MP0008260_abnormal_autophagy0.62791650
173MP0004742_abnormal_vestibular_system0.62475876
174MP0008961_abnormal_basal_metabolism0.62336546
175MP0003942_abnormal_urinary_system0.62278458
176MP0009763_increased_sensitivity_to0.61669921
177MP0004510_myositis0.60821281
178MP0005166_decreased_susceptibility_to0.60734141
179MP0000249_abnormal_blood_vessel0.60578188
180MP0009840_abnormal_foam_cell0.58500542
181MP0002138_abnormal_hepatobiliary_system0.57052515
182MP0004185_abnormal_adipocyte_glucose0.56492267
183MP0000920_abnormal_myelination0.56206850
184MP0001986_abnormal_taste_sensitivity0.55874206
185MP0008995_early_reproductive_senescence0.55219877
186MP0005645_abnormal_hypothalamus_physiol0.53838387
187MP0003448_altered_tumor_morphology0.51943934
188MP0001919_abnormal_reproductive_system0.51170505
189MP0001663_abnormal_digestive_system0.50594153
190MP0003091_abnormal_cell_migration0.47772158

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)4.91983896
2Ependymoma (HP:0002888)4.51943486
3Chronic mucocutaneous candidiasis (HP:0002728)4.48853302
4Recurrent cutaneous fungal infections (HP:0011370)4.48853302
5Colitis (HP:0002583)4.48813866
6Panhypogammaglobulinemia (HP:0003139)4.40759767
7Recurrent bacterial skin infections (HP:0005406)4.40507310
8Abnormality of the lower motor neuron (HP:0002366)4.39099662
9Recurrent fungal infections (HP:0002841)4.36640514
10Abnormal delayed hypersensitivity skin test (HP:0002963)4.35208381
11Recurrent viral infections (HP:0004429)4.23020349
12Recurrent abscess formation (HP:0002722)4.06932081
13Supernumerary spleens (HP:0009799)3.97589057
14Eczematoid dermatitis (HP:0000976)3.94090791
15Abnormality of the fingertips (HP:0001211)3.91115175
16Chromosomal breakage induced by crosslinking agents (HP:0003221)3.78868418
17Rib fusion (HP:0000902)3.73177832
18Hypochromic microcytic anemia (HP:0004840)3.60753552
19Nephroblastoma (Wilms tumor) (HP:0002667)3.60168064
20Chromsome breakage (HP:0040012)3.58503636
21Rhabdomyosarcoma (HP:0002859)3.52332986
22Inflammation of the large intestine (HP:0002037)3.51692454
23Recurrent skin infections (HP:0001581)3.50003263
24T lymphocytopenia (HP:0005403)3.47165671
25Meningitis (HP:0001287)3.46597548
26Impulsivity (HP:0100710)3.45845265
27Aplasia/hypoplasia of the humerus (HP:0006507)3.45799431
28Mediastinal lymphadenopathy (HP:0100721)3.44261642
29Neoplasm of striated muscle (HP:0009728)3.43384031
30Short humerus (HP:0005792)3.39914808
31Agammaglobulinemia (HP:0004432)3.38648435
32Abnormality of the astrocytes (HP:0100707)3.37468661
33Astrocytoma (HP:0009592)3.37468661
34Embryonal renal neoplasm (HP:0011794)3.36061883
35Hepatoblastoma (HP:0002884)3.35672697
36Stomatitis (HP:0010280)3.35363548
37Gastrointestinal inflammation (HP:0004386)3.34640062
38Selective tooth agenesis (HP:0001592)3.30258625
39Abnormality of T cell number (HP:0011839)3.30219339
40Autoimmune hemolytic anemia (HP:0001890)3.23286978
41Recurrent bronchitis (HP:0002837)3.20264598
42IgM deficiency (HP:0002850)3.18658787
43Autoimmune thrombocytopenia (HP:0001973)3.11189614
44Multiple enchondromatosis (HP:0005701)3.10424178
45Increased IgE level (HP:0003212)3.08626125
46Encephalitis (HP:0002383)3.07129934
47Vasculitis (HP:0002633)3.00894372
48Recurrent sinusitis (HP:0011108)2.99125763
49Rectal fistula (HP:0100590)2.95408327
50Rectovaginal fistula (HP:0000143)2.95408327
51Abnormality of T cells (HP:0002843)2.95123334
52Increased cerebral lipofuscin (HP:0011813)2.94403202
53Chronic otitis media (HP:0000389)2.94098545
54Medulloblastoma (HP:0002885)2.91533077
55Abnormality of the labia minora (HP:0012880)2.89435405
56Fused cervical vertebrae (HP:0002949)2.89434733
57Amyotrophic lateral sclerosis (HP:0007354)2.89008182
58Gastrointestinal stroma tumor (HP:0100723)2.87259711
59Increased neuronal autofluorescent lipopigment (HP:0002074)2.86320692
60Elevated erythrocyte sedimentation rate (HP:0003565)2.86075085
61Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.84080796
62Missing ribs (HP:0000921)2.78307654
63Spontaneous hematomas (HP:0007420)2.77825596
64Abnormal lung lobation (HP:0002101)2.77175039
65Viral hepatitis (HP:0006562)2.75403890
66Meckel diverticulum (HP:0002245)2.75381661
67Lymphopenia (HP:0001888)2.74893127
68Abnormality of macrophages (HP:0004311)2.73235317
69Glioma (HP:0009733)2.73184009
70Osteomyelitis (HP:0002754)2.70051737
71Abnormality of T cell physiology (HP:0011840)2.68522771
72Intestinal fistula (HP:0100819)2.67936940
73IgA deficiency (HP:0002720)2.66203692
74Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.65016148
75Chronic diarrhea (HP:0002028)2.62764887
76Abnormality of B cell number (HP:0010975)2.61241552
77Shawl scrotum (HP:0000049)2.60266635
78Myositis (HP:0100614)2.57757796
79Aplasia/Hypoplasia of the uvula (HP:0010293)2.57702176
80Abnormality of the ileum (HP:0001549)2.57576671
81Abnormality of cells of the lymphoid lineage (HP:0012140)2.56854677
82Pustule (HP:0200039)2.54605444
83Granulocytopenia (HP:0001913)2.54380101
84Retrobulbar optic neuritis (HP:0100654)2.49897112
85Optic neuritis (HP:0100653)2.49897112
86IgG deficiency (HP:0004315)2.48705667
87Vaginal fistula (HP:0004320)2.47681652
88Preauricular skin tag (HP:0000384)2.46714615
89Acute myeloid leukemia (HP:0004808)2.42397285
90Absent radius (HP:0003974)2.42007880
91B lymphocytopenia (HP:0010976)2.41013608
92Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.40002128
93Obstructive lung disease (HP:0006536)2.38285534
94Chronic obstructive pulmonary disease (HP:0006510)2.38285534
95Recurrent gram-negative bacterial infections (HP:0005420)2.37319433
96Abnormality of the salivary glands (HP:0010286)2.35743307
97Trismus (HP:0000211)2.35534960
98Cellulitis (HP:0100658)2.32671530
99Leukocytosis (HP:0001974)2.31566568
100Dysmetric saccades (HP:0000641)2.30696630
101Hypoplasia of the thymus (HP:0000778)2.30606550
102Severe combined immunodeficiency (HP:0004430)2.29678125
103Hemoptysis (HP:0002105)2.28619095
104Pulmonary infiltrates (HP:0002113)2.27717803
105Absent forearm bone (HP:0003953)2.27430468
106Aplasia involving forearm bones (HP:0009822)2.27430468
107Skin tags (HP:0010609)2.27338017
108Orchitis (HP:0100796)2.25068843
109Neoplasm of the oral cavity (HP:0100649)2.24734044
110Hypopigmentation of the fundus (HP:0007894)2.23985299
111Prominent nose (HP:0000448)2.23746248
112Gingivitis (HP:0000230)2.23175553
113Eosinophilia (HP:0001880)2.22670510
114Slow saccadic eye movements (HP:0000514)2.21159205
115Facial cleft (HP:0002006)2.20037251
116Renal duplication (HP:0000075)2.18963259
117Increased nuchal translucency (HP:0010880)2.18499503
118Chest pain (HP:0100749)2.17686635
119Fatigue (HP:0012378)2.16891421
120Abnormality of the prostate (HP:0008775)2.16048492
121Atrophy/Degeneration involving motor neurons (HP:0007373)2.14444217
122Acute lymphatic leukemia (HP:0006721)2.14434301
123Upper motor neuron abnormality (HP:0002127)2.14245081
124Supernumerary ribs (HP:0005815)2.12504078
125Aplasia/Hypoplasia of the sternum (HP:0006714)2.11421599
126Large earlobe (HP:0009748)2.11198106
127Horizontal nystagmus (HP:0000666)2.09886724
128Partial duplication of thumb phalanx (HP:0009944)2.09850440
129Volvulus (HP:0002580)2.09498338
130Abnormality of the distal phalanx of the thumb (HP:0009617)2.08234901
131Duodenal stenosis (HP:0100867)2.07925920
132Small intestinal stenosis (HP:0012848)2.07925920
133Abnormality of the phalanges of the hallux (HP:0010057)2.07829663
134Combined immunodeficiency (HP:0005387)2.07449393
135Restrictive lung disease (HP:0002091)2.04114000
136Abnormality of eosinophils (HP:0001879)2.01859296
137Gastrointestinal infarctions (HP:0005244)2.01811262
138Hematochezia (HP:0002573)2.01693587
139Supernumerary bones of the axial skeleton (HP:0009144)2.01624841
140Testicular atrophy (HP:0000029)2.01549646
141Abnormality of chromosome stability (HP:0003220)2.01321487
142Spinal muscular atrophy (HP:0007269)2.00435372
143Atresia of the external auditory canal (HP:0000413)1.99432373
144Albinism (HP:0001022)1.99208451
145Aplastic anemia (HP:0001915)1.98475960
146Papilloma (HP:0012740)1.97685729
147Verrucae (HP:0200043)1.97685729
148Basal cell carcinoma (HP:0002671)1.97648675
149Narrow palate (HP:0000189)1.96308599
150Bifid tongue (HP:0010297)1.96106399
151Muscle fibrillation (HP:0010546)1.95141953
152Pseudobulbar signs (HP:0002200)1.93436377
153Hypochromic anemia (HP:0001931)1.93311960
154Abnormality of the columella (HP:0009929)1.93083295
155Hepatitis (HP:0012115)1.92779543
156Vertebral fusion (HP:0002948)1.92510707
157Limb hypertonia (HP:0002509)1.92159129
158Abnormality of the preputium (HP:0100587)1.92097134
159Lymphoma (HP:0002665)1.90935657
160Abnormal number of incisors (HP:0011064)1.90790305
161Deviation of the thumb (HP:0009603)1.90095821
162Neuronal loss in central nervous system (HP:0002529)1.89340694
163Abnormality of the anterior horn cell (HP:0006802)1.88406205
164Degeneration of anterior horn cells (HP:0002398)1.88406205
165Sloping forehead (HP:0000340)1.86308439
166Abnormality of abdominal situs (HP:0011620)1.86261378
167Abdominal situs inversus (HP:0003363)1.86261378
168Prolonged bleeding time (HP:0003010)1.85849677
16911 pairs of ribs (HP:0000878)1.85628379
170Abnormality of chromosome segregation (HP:0002916)1.84088279
171Myelodysplasia (HP:0002863)1.83436339
172Partial duplication of the phalanx of hand (HP:0009999)1.83039214
173Abnormality of the duodenum (HP:0002246)1.81641576
174Premature ovarian failure (HP:0008209)1.81472885
175Absent frontal sinuses (HP:0002688)1.80984998
176Clumsiness (HP:0002312)1.79875118
177Proximal placement of thumb (HP:0009623)1.79709393
178Tongue fasciculations (HP:0001308)1.79387177
179Breast hypoplasia (HP:0003187)1.78689178
180Ectopic kidney (HP:0000086)1.78354569
181Aplasia/Hypoplasia of the thymus (HP:0010515)1.77745336
182Abnormality of the musculature of the hand (HP:0001421)1.77497120
183Sepsis (HP:0100806)1.76671795
184Duplication of thumb phalanx (HP:0009942)1.76393715
185Nasal polyposis (HP:0100582)1.76323765
186Protruding tongue (HP:0010808)1.75711212
187Keratoconjunctivitis sicca (HP:0001097)1.75523866
188Abnormal respiratory motile cilium physiology (HP:0012261)1.75189960
189Increased CSF protein (HP:0002922)1.74809718
190Abnormality of the nasal mucosa (HP:0000433)1.74477992
191Birth length less than 3rd percentile (HP:0003561)1.74036267
192Hyperinsulinemic hypoglycemia (HP:0000825)1.72637286
193Malignant neoplasm of the central nervous system (HP:0100836)1.72001552
194Delayed puberty (HP:0000823)1.70841388
195Hemivertebrae (HP:0002937)1.70737668
196Tracheoesophageal fistula (HP:0002575)1.70292895
197Short 5th finger (HP:0009237)1.70210123
198Gastrointestinal carcinoma (HP:0002672)1.69579622

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.28465390
2MAP4K13.59315368
3PLK43.52548189
4RIPK43.28907005
5TTK3.07721421
6CDC72.96123139
7PRPF4B2.79810577
8WEE12.69892252
9EPHA22.59875897
10GRK52.56456947
11GRK62.56362260
12BLK2.54782304
13TYK22.53669060
14MAP3K142.49555368
15STK102.49413871
16JAK12.23571281
17MAP3K132.14007967
18TXK2.09445315
19TYRO32.08592724
20JAK32.03886412
21CDK71.99688657
22RPS6KB21.96943547
23NEK21.94376816
24TEC1.88279472
25ITK1.84151455
26TAOK31.77449995
27PLK11.77314542
28BTK1.71258720
29ERN11.69899920
30SYK1.69802205
31IKBKE1.69237611
32CAMK1D1.68203955
33PDK41.65016483
34PDK31.65016483
35PNCK1.63868698
36FES1.58850682
37ADRBK21.57669357
38CHEK21.53770184
39NEK11.53745941
40GRK11.52551520
41CSF1R1.51388616
42KIT1.48777520
43CAMK1G1.46355440
44CHEK11.41889157
45BRD41.39626432
46AKT31.39094057
47ALK1.38657795
48BMPR21.33848207
49SRPK11.30430575
50IRAK41.29565516
51IKBKB1.28124381
52FGFR31.27784943
53WNK11.26404975
54HCK1.24224006
55MAPK71.24210507
56IRAK11.22678198
57MAP2K31.22478849
58PAK41.22266290
59MAPK121.21368118
60ZAP701.19595782
61BUB11.19134571
62MATK1.19129422
63CAMKK21.18236369
64LCK1.13726892
65SIK21.13658397
66HIPK21.12996453
67JAK21.11600881
68LYN1.10863469
69ACVR1B1.10399268
70LATS21.10202807
71MTOR1.04706781
72TNK21.04205543
73PDK21.03807409
74NLK1.02746124
75PRKG21.02283743
76AURKB0.97094041
77PDK10.93953684
78TSSK60.92748706
79ATM0.92338242
80SCYL20.90106749
81ATR0.90051325
82TBK10.89899195
83MAPK110.89850581
84CDK20.89730674
85MST40.89515326
86CAMKK10.86972073
87PLK30.85006372
88AKT20.84811012
89ICK0.84727575
90SGK20.84229706
91PRKCI0.83297239
92AURKA0.82809009
93TRIB30.81793335
94GRK70.81498852
95CDK40.81395589
96FGFR40.80408983
97CHUK0.79596645
98MAP3K80.78912538
99TRPM70.78467441
100MOS0.77716150
101PASK0.75862501
102FRK0.75680908
103MAP3K100.74803394
104CDK60.73953636
105TGFBR20.73220400
106PRKCQ0.73112742
107SGK30.70349514
108IRAK30.68266355
109EPHA30.67661251
110TESK20.67641067
111CAMK40.67325019
112PIK3CG0.66773018
113RET0.66413349
114CSNK1E0.64208667
115MAP3K10.63187182
116MAP3K70.62402023
117STK38L0.62256906
118DYRK30.62044341
119CDK10.61408141
120EEF2K0.60423178
121KSR20.60219879
122PRKD30.58818786
123MAP3K20.58700720
124PKN20.57919326
125FGR0.57510964
126PAK10.52251363
127CDC42BPA0.51928701
128YES10.51575414
129STK240.50986633
130MKNK20.50014610
131PDGFRA0.49348798
132PTK20.49331918
133ADRBK10.48086074
134RAF10.47624480
135SMG10.46537673
136BRSK20.44799409
137LATS10.44794084
138STK30.44639359
139PDPK10.44126849
140NEK90.44050449
141MKNK10.43997108
142VRK10.43422719
143RPS6KA50.42869840
144MET0.42096099
145CSNK1D0.40733405
146IRAK20.39069984
147MAP3K90.38632718
148BMX0.37546641
149CSK0.37070846
150MAPK140.36804617
151PAK20.36518244
152MELK0.36479678
153PRKCH0.35289263
154PIM10.35103472
155MAPK100.34915980
156STK380.34488536
157MARK20.34285721
158SGK10.34062084
159RPS6KA60.33585424
160TESK10.33292107
161GSK3B0.33211548
162MAPK10.32152513
163RPS6KL10.30663187
164RPS6KC10.30663187
165CSNK2A20.30282219
166TLK10.29922497
167MAPK30.29551764
168STK40.29477358
169MARK30.29468103
170EIF2AK20.28734605
171MAPKAPK30.28712524
172LRRK20.28534296
173EIF2AK10.26548766
174AKT10.26096574

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.90198365
2RNA transport_Homo sapiens_hsa030133.48058859
3Vitamin B6 metabolism_Homo sapiens_hsa007503.16621844
4DNA replication_Homo sapiens_hsa030302.92907626
5Mismatch repair_Homo sapiens_hsa034302.90385874
6Primary immunodeficiency_Homo sapiens_hsa053402.74820773
7Graft-versus-host disease_Homo sapiens_hsa053322.71826849
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.68543558
9Allograft rejection_Homo sapiens_hsa053302.62267921
10One carbon pool by folate_Homo sapiens_hsa006702.58414125
11Fanconi anemia pathway_Homo sapiens_hsa034602.57975721
12B cell receptor signaling pathway_Homo sapiens_hsa046622.53961848
13Spliceosome_Homo sapiens_hsa030402.52986048
14Autoimmune thyroid disease_Homo sapiens_hsa053202.49501915
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.44250934
16Cell cycle_Homo sapiens_hsa041102.43381551
17mRNA surveillance pathway_Homo sapiens_hsa030152.37240683
18Intestinal immune network for IgA production_Homo sapiens_hsa046722.37152260
19Homologous recombination_Homo sapiens_hsa034402.35011237
20Leishmaniasis_Homo sapiens_hsa051402.33382279
21Osteoclast differentiation_Homo sapiens_hsa043802.27564033
22Basal transcription factors_Homo sapiens_hsa030222.22752195
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.17266844
24Asthma_Homo sapiens_hsa053102.10513160
25Type I diabetes mellitus_Homo sapiens_hsa049402.07355284
26T cell receptor signaling pathway_Homo sapiens_hsa046602.06382180
27Staphylococcus aureus infection_Homo sapiens_hsa051502.05013239
28NF-kappa B signaling pathway_Homo sapiens_hsa040642.04468759
29Nucleotide excision repair_Homo sapiens_hsa034202.00398214
30Fructose and mannose metabolism_Homo sapiens_hsa000511.96879892
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.96560108
32RNA polymerase_Homo sapiens_hsa030201.90201618
33Measles_Homo sapiens_hsa051621.89943600
34RNA degradation_Homo sapiens_hsa030181.88035838
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.84899250
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.78698859
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.75841728
38Tuberculosis_Homo sapiens_hsa051521.71923282
39Base excision repair_Homo sapiens_hsa034101.68322618
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.62108116
41Non-homologous end-joining_Homo sapiens_hsa034501.58440979
42Thyroid cancer_Homo sapiens_hsa052161.53516036
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44704185
44Toxoplasmosis_Homo sapiens_hsa051451.43479483
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.43192062
46Linoleic acid metabolism_Homo sapiens_hsa005911.43048220
47Ribosome_Homo sapiens_hsa030101.42173129
48Galactose metabolism_Homo sapiens_hsa000521.37656368
49Viral myocarditis_Homo sapiens_hsa054161.35951786
50p53 signaling pathway_Homo sapiens_hsa041151.32948646
51Hematopoietic cell lineage_Homo sapiens_hsa046401.32581461
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.27982550
53TNF signaling pathway_Homo sapiens_hsa046681.27783165
54Hepatitis B_Homo sapiens_hsa051611.27385020
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25069620
56Pyrimidine metabolism_Homo sapiens_hsa002401.23490243
57Hippo signaling pathway_Homo sapiens_hsa043901.23131567
58Chemokine signaling pathway_Homo sapiens_hsa040621.21456553
59Rheumatoid arthritis_Homo sapiens_hsa053231.20258218
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17979510
61MicroRNAs in cancer_Homo sapiens_hsa052061.14962333
62mTOR signaling pathway_Homo sapiens_hsa041501.14034375
63Arachidonic acid metabolism_Homo sapiens_hsa005901.13288081
64Chronic myeloid leukemia_Homo sapiens_hsa052201.13133143
65Basal cell carcinoma_Homo sapiens_hsa052171.08522505
66Other glycan degradation_Homo sapiens_hsa005111.07814460
67Prolactin signaling pathway_Homo sapiens_hsa049171.07562031
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05007575
69Neurotrophin signaling pathway_Homo sapiens_hsa047221.03971998
70Central carbon metabolism in cancer_Homo sapiens_hsa052301.03764255
71Oocyte meiosis_Homo sapiens_hsa041141.03665833
72Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02310445
73Viral carcinogenesis_Homo sapiens_hsa052031.01274793
74Pancreatic cancer_Homo sapiens_hsa052121.01040515
75Legionellosis_Homo sapiens_hsa051340.99489205
76Platelet activation_Homo sapiens_hsa046110.97095536
77Hepatitis C_Homo sapiens_hsa051600.95896162
78Hedgehog signaling pathway_Homo sapiens_hsa043400.91890590
79Adherens junction_Homo sapiens_hsa045200.90980522
80Tight junction_Homo sapiens_hsa045300.89303795
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88297542
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87287898
83Proteasome_Homo sapiens_hsa030500.87128735
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82742643
85Antigen processing and presentation_Homo sapiens_hsa046120.82646301
86Pentose phosphate pathway_Homo sapiens_hsa000300.82317026
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82191185
88Type II diabetes mellitus_Homo sapiens_hsa049300.81490838
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79591141
90Systemic lupus erythematosus_Homo sapiens_hsa053220.79329825
91Pertussis_Homo sapiens_hsa051330.78367516
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78112088
93FoxO signaling pathway_Homo sapiens_hsa040680.77436805
94HTLV-I infection_Homo sapiens_hsa051660.76477886
95Pathways in cancer_Homo sapiens_hsa052000.76230889
96Herpes simplex infection_Homo sapiens_hsa051680.76185780
97Selenocompound metabolism_Homo sapiens_hsa004500.72553132
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71982613
99Malaria_Homo sapiens_hsa051440.69267237
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69161372
101GnRH signaling pathway_Homo sapiens_hsa049120.68406386
102Lysine degradation_Homo sapiens_hsa003100.68186246
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.67115786
104Small cell lung cancer_Homo sapiens_hsa052220.67040428
105Glioma_Homo sapiens_hsa052140.66960269
106TGF-beta signaling pathway_Homo sapiens_hsa043500.66395667
107Notch signaling pathway_Homo sapiens_hsa043300.65441792
108Epstein-Barr virus infection_Homo sapiens_hsa051690.65165490
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63713164
110Acute myeloid leukemia_Homo sapiens_hsa052210.63099232
111Long-term potentiation_Homo sapiens_hsa047200.61472000
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61461314
113ErbB signaling pathway_Homo sapiens_hsa040120.60235991
114Phagosome_Homo sapiens_hsa041450.59927743
115Proteoglycans in cancer_Homo sapiens_hsa052050.59752724
116Dorso-ventral axis formation_Homo sapiens_hsa043200.59604757
117Colorectal cancer_Homo sapiens_hsa052100.59134267
118Wnt signaling pathway_Homo sapiens_hsa043100.58867008
119Purine metabolism_Homo sapiens_hsa002300.57612146
120Lysosome_Homo sapiens_hsa041420.57239868
121Inositol phosphate metabolism_Homo sapiens_hsa005620.57100444
122African trypanosomiasis_Homo sapiens_hsa051430.55418123
123MAPK signaling pathway_Homo sapiens_hsa040100.54974985
124Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54293171
125Biosynthesis of amino acids_Homo sapiens_hsa012300.52631270
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52504693
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52385858
128Bladder cancer_Homo sapiens_hsa052190.52156173
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51404743
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49589807
131Rap1 signaling pathway_Homo sapiens_hsa040150.48666245
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.47120731
133Insulin resistance_Homo sapiens_hsa049310.47068407
134Estrogen signaling pathway_Homo sapiens_hsa049150.46510444
135Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46102414
136Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45431923
137Adipocytokine signaling pathway_Homo sapiens_hsa049200.44273057
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43229363
139Ether lipid metabolism_Homo sapiens_hsa005650.42834813
140Cysteine and methionine metabolism_Homo sapiens_hsa002700.42767741
141Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42168079
142Prostate cancer_Homo sapiens_hsa052150.41125736
143SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40072226
144Phospholipase D signaling pathway_Homo sapiens_hsa040720.39747877
145Shigellosis_Homo sapiens_hsa051310.39139080
146HIF-1 signaling pathway_Homo sapiens_hsa040660.38664721
147Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38276136
148Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38211244
149Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37419287
150Non-small cell lung cancer_Homo sapiens_hsa052230.36673959
151Endometrial cancer_Homo sapiens_hsa052130.36451556
152Oxytocin signaling pathway_Homo sapiens_hsa049210.36378929
153Choline metabolism in cancer_Homo sapiens_hsa052310.36133597
154Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35220649
155Renal cell carcinoma_Homo sapiens_hsa052110.33771794
156Cyanoamino acid metabolism_Homo sapiens_hsa004600.31799231
157Apoptosis_Homo sapiens_hsa042100.31359851
158VEGF signaling pathway_Homo sapiens_hsa043700.30766898
159PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30493760
160Focal adhesion_Homo sapiens_hsa045100.29083096
161Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27028485
162Alcoholism_Homo sapiens_hsa050340.26630225
163Carbon metabolism_Homo sapiens_hsa012000.25690324
164AMPK signaling pathway_Homo sapiens_hsa041520.24028282
165Melanoma_Homo sapiens_hsa052180.23249258
166Glycerophospholipid metabolism_Homo sapiens_hsa005640.22312909
167ECM-receptor interaction_Homo sapiens_hsa045120.21958076
168Influenza A_Homo sapiens_hsa051640.20031163

Most similar genes based on co-expression Upload to Enrichr

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