SFN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* keratinization (GO:0031424)9.89062566
2* establishment of skin barrier (GO:0061436)7.57507224
3* regulation of water loss via skin (GO:0033561)7.50325587
4intermediate filament organization (GO:0045109)7.35624630
5bundle of His cell to Purkinje myocyte communication (GO:0086069)6.39277651
6interferon-gamma secretion (GO:0072643)6.01157923
7surfactant homeostasis (GO:0043129)5.79541775
8keratinocyte differentiation (GO:0030216)5.54716211
9gap junction assembly (GO:0016264)5.41824366
10intestinal epithelial cell development (GO:0060576)5.39833039
11peptide cross-linking (GO:0018149)5.25671822
12negative regulation of macroautophagy (GO:0016242)5.04179628
13epidermis development (GO:0008544)4.95824242
14* multicellular organismal water homeostasis (GO:0050891)4.79961584
15chemical homeostasis within a tissue (GO:0048875)4.73958705
16skin morphogenesis (GO:0043589)4.68257817
17establishment of planar polarity (GO:0001736)4.61747121
18establishment of tissue polarity (GO:0007164)4.61747121
19intermediate filament cytoskeleton organization (GO:0045104)4.56096754
20epidermal cell differentiation (GO:0009913)4.45424091
21intermediate filament-based process (GO:0045103)4.45181936
22polarized epithelial cell differentiation (GO:0030859)4.39805826
23positive regulation of keratinocyte differentiation (GO:0045618)4.30381018
24epithelial cell differentiation involved in prostate gland development (GO:0060742)4.22370963
25* negative regulation of keratinocyte proliferation (GO:0010839)4.18378524
26ectoderm development (GO:0007398)4.15960187
27epithelial cell-cell adhesion (GO:0090136)4.14738184
28cell-substrate junction assembly (GO:0007044)4.14700880
29* regulation of keratinocyte proliferation (GO:0010837)4.13878259
30lung-associated mesenchyme development (GO:0060484)4.12312610
31ribosome assembly (GO:0042255)4.07066030
32* water homeostasis (GO:0030104)3.95032053
33positive regulation of hair follicle development (GO:0051798)3.92230124
34positive regulation of hair cycle (GO:0042635)3.92230124
35protein localization to endosome (GO:0036010)3.88276472
36dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.85555545
37regulation of hair follicle development (GO:0051797)3.80848624
38adhesion of symbiont to host cell (GO:0044650)3.68244229
39virion attachment to host cell (GO:0019062)3.68244229
40cell adhesion mediated by integrin (GO:0033627)3.66772064
41negative regulation of chondrocyte differentiation (GO:0032331)3.62038281
42trophectodermal cell differentiation (GO:0001829)3.61775614
43* positive regulation of epidermal cell differentiation (GO:0045606)3.48740709
44lateral sprouting from an epithelium (GO:0060601)3.43267717
45long-chain fatty acid biosynthetic process (GO:0042759)3.40464952
46maturation of SSU-rRNA (GO:0030490)3.38745499
47cytoskeletal anchoring at plasma membrane (GO:0007016)3.38458225
48cell junction assembly (GO:0034329)3.35755748
49hypotonic response (GO:0006971)3.33933734
50negative regulation of cell fate specification (GO:0009996)3.31063622
51keratinocyte proliferation (GO:0043616)3.27527179
52epithelium development (GO:0060429)3.27473668
53formation of translation preinitiation complex (GO:0001731)3.26476608
54cell junction organization (GO:0034330)3.25732677
55regulation of cardioblast differentiation (GO:0051890)3.24957025
56regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.24002013
57regulation of keratinocyte differentiation (GO:0045616)3.23522956
58ribosomal small subunit biogenesis (GO:0042274)3.20713815
59skin development (GO:0043588)3.19197927
60purine nucleobase biosynthetic process (GO:0009113)3.17249386
61planar cell polarity pathway involved in neural tube closure (GO:0090179)3.15527891
62* regulation of epidermis development (GO:0045682)3.12419012
63atrioventricular valve morphogenesis (GO:0003181)3.11753383
64ribosomal large subunit biogenesis (GO:0042273)3.07729452
65hair follicle morphogenesis (GO:0031069)3.06936271
66negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.05826179
67cytidine deamination (GO:0009972)3.02404936
68cytidine metabolic process (GO:0046087)3.02404936
69cytidine catabolic process (GO:0006216)3.02404936
70ventricular cardiac muscle cell action potential (GO:0086005)2.99657181
71regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.99368098
72lipoxygenase pathway (GO:0019372)2.95875439
73* keratinocyte development (GO:0003334)2.95675781
74cell-substrate adherens junction assembly (GO:0007045)2.95472668
75focal adhesion assembly (GO:0048041)2.95472668
76activation of Rac GTPase activity (GO:0032863)2.95310068
77* positive regulation of epidermis development (GO:0045684)2.95125075
78nucleobase biosynthetic process (GO:0046112)2.92772602
79negative regulation of T cell differentiation in thymus (GO:0033085)2.91173510
80eyelid development in camera-type eye (GO:0061029)2.89065866
81positive regulation of monocyte chemotaxis (GO:0090026)2.88578800
82renal filtration (GO:0097205)2.88180039
83wound healing, spreading of epidermal cells (GO:0035313)2.83686614
84adhesion of symbiont to host (GO:0044406)2.83580370
85L-serine transport (GO:0015825)2.83258324
86regulation of chemokine secretion (GO:0090196)2.81398366
87viral transcription (GO:0019083)2.80654101
88regulation of heart rate by cardiac conduction (GO:0086091)2.79288993
89negative regulation of epidermis development (GO:0045683)2.78547994
90translational initiation (GO:0006413)2.76425848
91endodermal cell differentiation (GO:0035987)2.76078177
92regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.75742966
93mammary gland epithelial cell proliferation (GO:0033598)2.75032476
94negative regulation of interferon-gamma production (GO:0032689)2.74427680
95translational termination (GO:0006415)2.73848646
96protein neddylation (GO:0045116)2.73661322
97cell communication involved in cardiac conduction (GO:0086065)2.70242848
98positive regulation of T cell differentiation in thymus (GO:0033089)2.68734404
99regulation of endothelial cell chemotaxis (GO:2001026)2.67515429
100linoleic acid metabolic process (GO:0043651)2.65641393
101ribonucleoprotein complex biogenesis (GO:0022613)2.65334136
102morphogenesis of embryonic epithelium (GO:0016331)2.64877381
103mitotic G2 DNA damage checkpoint (GO:0007095)2.63432450
104regulation of hair cycle (GO:0042634)2.63420481
105negative regulation of stem cell proliferation (GO:2000647)2.63080329
106mitotic G1 DNA damage checkpoint (GO:0031571)2.61929697
107regulation of autophagic vacuole assembly (GO:2000785)2.61580970
108positive regulation of Cdc42 GTPase activity (GO:0043089)2.61008861
109phosphatidylserine acyl-chain remodeling (GO:0036150)2.60922598
110adherens junction organization (GO:0034332)2.59966628
111wound healing (GO:0042060)2.59865383
112regulation of translational termination (GO:0006449)2.58666740
113adherens junction assembly (GO:0034333)2.57962536
114folic acid transport (GO:0015884)2.57333200
115membrane tubulation (GO:0097320)2.56643791
116epithelial cell proliferation (GO:0050673)2.56222187
117cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.53489532
118Golgi transport vesicle coating (GO:0048200)2.53256059
119COPI coating of Golgi vesicle (GO:0048205)2.53256059
120cell-cell junction assembly (GO:0007043)2.52193710
121membrane raft organization (GO:0031579)2.50998708
122cell differentiation involved in embryonic placenta development (GO:0060706)2.50743803
123negative regulation of cell fate commitment (GO:0010454)2.49657510
124proteasome assembly (GO:0043248)2.49193116
125tight junction assembly (GO:0070830)2.48293469
126hair cycle process (GO:0022405)2.47413608
127molting cycle process (GO:0022404)2.47413608
128mitotic metaphase plate congression (GO:0007080)2.46984174
129negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.46788703
130negative regulation of cartilage development (GO:0061037)2.46349042
131regulation of posttranscriptional gene silencing (GO:0060147)2.46001544
132regulation of gene silencing by miRNA (GO:0060964)2.46001544
133regulation of gene silencing by RNA (GO:0060966)2.46001544
134regulation of vitamin metabolic process (GO:0030656)2.45996565
135gland morphogenesis (GO:0022612)2.45675450
136cardiac right ventricle morphogenesis (GO:0003215)2.44084145
137branching involved in labyrinthine layer morphogenesis (GO:0060670)2.43676210
138ribosome biogenesis (GO:0042254)2.43326371
139blastocyst development (GO:0001824)2.41864786
140mesodermal cell differentiation (GO:0048333)2.40899208
141viral life cycle (GO:0019058)2.40710538
142chondrocyte proliferation (GO:0035988)2.40250775
143translational elongation (GO:0006414)2.38843105
144* regulation of epidermal cell differentiation (GO:0045604)2.38115793
145vitamin transmembrane transport (GO:0035461)2.36334082
146regulation of transforming growth factor beta2 production (GO:0032909)2.34841850
147regulation of G0 to G1 transition (GO:0070316)2.34088685
148negative regulation of epidermal cell differentiation (GO:0045605)2.33541921
149branching involved in mammary gland duct morphogenesis (GO:0060444)2.33179479
150hair cycle (GO:0042633)13.6145462
151molting cycle (GO:0042303)13.6145462
152hemidesmosome assembly (GO:0031581)12.0735508
153desmosome organization (GO:0002934)10.9612566

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.99795980
2ZNF263_19887448_ChIP-Seq_K562_Human2.66732372
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.66452975
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.62550574
5* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.37386600
6E2F7_22180533_ChIP-Seq_HELA_Human2.29792195
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.27864683
8* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.22438083
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.01866220
10NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.00780480
11* TP63_17297297_ChIP-ChIP_HaCaT_Human12.7635834
12POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.92080031
13MYC_18555785_ChIP-Seq_MESCs_Mouse1.89309277
14ESR1_21235772_ChIP-Seq_MCF-7_Human1.86705595
15* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.82393746
16* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.82393746
17* ATF3_27146783_Chip-Seq_COLON_Human1.79722700
18* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.77265161
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.76413392
20AR_21909140_ChIP-Seq_LNCAP_Human1.74380560
21NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68534197
22FOXM1_23109430_ChIP-Seq_U2OS_Human1.68379564
23* RACK7_27058665_Chip-Seq_MCF-7_Human1.68061973
24KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.65041100
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.63641043
26SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.58607564
27SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.57106695
28TCF3_18692474_ChIP-Seq_MEFs_Mouse1.55981342
29* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.54484215
30KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.52272993
31KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.52272993
32KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.52272993
33STAT3_1855785_ChIP-Seq_MESCs_Mouse1.49311923
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48636751
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.48449557
36CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.45569792
37* TP63_23658742_ChIP-Seq_EP156T_Human1.44467297
38NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.44172497
39UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41250100
40SRY_22984422_ChIP-ChIP_TESTIS_Rat1.38220027
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.35417137
42SOX9_24532713_ChIP-Seq_HFSC_Mouse1.34490711
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33319432
44NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.32764957
45BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.30906311
46RUNX1_27514584_Chip-Seq_MCF-7_Human1.28932276
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.27155571
48* GATA6_25053715_ChIP-Seq_YYC3_Human1.26615057
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24647617
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.23724931
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.22961259
52TRIM28_21343339_ChIP-Seq_HEK293_Human1.21883895
53* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.21455093
54EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.20380821
55* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18074591
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.18020372
57* ELK3_25401928_ChIP-Seq_HUVEC_Human1.16570901
58GATA4_25053715_ChIP-Seq_YYC3_Human1.13543445
59MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11694467
60YY1_22570637_ChIP-Seq_MALME-3M_Human1.10590716
61* TP63_22573176_ChIP-Seq_HFKS_Human1.10307903
62* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10003264
63SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09218983
64* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07514656
65SOX2_18692474_ChIP-Seq_MEFs_Mouse1.06815888
66RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06806968
67MYC_19030024_ChIP-ChIP_MESCs_Mouse1.06230487
68* KLF5_25053715_ChIP-Seq_YYC3_Human1.05238853
69ETS1_20019798_ChIP-Seq_JURKAT_Human1.04713577
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04278704
71* UBF1/2_26484160_Chip-Seq_HMECs_Human1.04277381
72ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04173268
73* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03427607
74GATA3_24758297_ChIP-Seq_MCF-7_Human1.03221616
75* XRN2_22483619_ChIP-Seq_HELA_Human1.02786040
76P68_20966046_ChIP-Seq_HELA_Human1.01451115
77CTCF_20526341_ChIP-Seq_ESCs_Human1.01370843
78FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00997131
79KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99182810
80ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99181335
81* BCOR_27268052_Chip-Seq_Bcells_Human0.99082277
82CDX2_20551321_ChIP-Seq_CACO-2_Human0.98933153
83* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98577297
84ERG_21242973_ChIP-ChIP_JURKAT_Human0.98366780
85* E2F1_20622854_ChIP-Seq_HELA_Human0.97809740
86TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97662479
87TP53_22127205_ChIP-Seq_IMR90_Human0.97035799
88SOX2_20726797_ChIP-Seq_SW620_Human0.96624647
89CREB1_15753290_ChIP-ChIP_HEK293T_Human0.95756562
90TCF3_18692474_ChIP-Seq_MESCs_Mouse0.95484373
91ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91921028
92CLOCK_20551151_ChIP-Seq_293T_Human0.91813642
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91687445
94* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91605765
95ELK1_22589737_ChIP-Seq_MCF10A_Human0.90634536
96NELFA_20434984_ChIP-Seq_ESCs_Mouse0.89854194
97* SA1_27219007_Chip-Seq_ERYTHROID_Human0.89265708
98CJUN_26792858_Chip-Seq_BT549_Human0.87832822
99NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.86225142
100PHF8_20622854_ChIP-Seq_HELA_Human0.86033984
101* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85674510
102SMC4_20622854_ChIP-Seq_HELA_Human0.85251543
103RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.84703797
104PPAR_26484153_Chip-Seq_NCI-H1993_Human0.84136558
105NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.83818700
106LXR_22292898_ChIP-Seq_THP-1_Human0.83085409
107* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.83054804
108EGR1_19032775_ChIP-ChIP_M12_Human0.82746308
109POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.82074998
110TET1_21490601_ChIP-Seq_MESCs_Mouse0.81549323
111* CTCF_27219007_Chip-Seq_Bcells_Human0.81390502
112KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.80726592
113PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.79073360
114* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.78666078
115ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78627225
116GATA2_21666600_ChIP-Seq_HMVEC_Human0.78492477
117* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.78273355
118PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.77812622
119RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75232875
120GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.75100889
121* TCF4_18268006_ChIP-ChIP_LS174T_Human0.73766647
122DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.73274496
123* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.72854512
124TBX20_22328084_ChIP-Seq_HEART_Mouse0.72444097
125TBX20_22080862_ChIP-Seq_HEART_Mouse0.72444097
126* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.71419963
127TP53_18474530_ChIP-ChIP_U2OS_Human0.70744350
128P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.67123657
129PPARA_22158963_ChIP-Seq_LIVER_Mouse0.66674491
130WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.66563478
131ESR1_20079471_ChIP-ChIP_T-47D_Human0.66120220
132CREB1_26743006_Chip-Seq_LNCaP_Human0.64453220
133* KDM2B_26808549_Chip-Seq_K562_Human0.63207296
134* CHD1_26751641_Chip-Seq_LNCaP_Human0.61995829
135TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.61626972

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.25729360
2MP0002796_impaired_skin_barrier5.80597825
3MP0000579_abnormal_nail_morphology5.16705243
4MP0005275_abnormal_skin_tensile4.03729680
5MP0005501_abnormal_skin_physiology3.71592761
6MP0002098_abnormal_vibrissa_morphology3.68973743
7MP0000383_abnormal_hair_follicle3.64054231
8MP0010678_abnormal_skin_adnexa3.54508130
9MP0002254_reproductive_system_inflammat3.41058355
10MP0003941_abnormal_skin_development3.23228423
11* MP0001216_abnormal_epidermal_layer2.94712888
12MP0000647_abnormal_sebaceous_gland2.94260083
13MP0000467_abnormal_esophagus_morphology2.93169544
14MP0003705_abnormal_hypodermis_morpholog2.91993183
15MP0003453_abnormal_keratinocyte_physiol2.76889202
16MP0002060_abnormal_skin_morphology2.64494818
17MP0004381_abnormal_hair_follicle2.45872328
18* MP0000377_abnormal_hair_follicle2.42342744
19* MP0000762_abnormal_tongue_morphology2.23050937
20MP0010771_integument_phenotype2.21361360
21MP0004947_skin_inflammation2.17733573
22MP0003693_abnormal_embryo_hatching2.09711597
23MP0000427_abnormal_hair_cycle2.06177067
24MP0001849_ear_inflammation1.85439745
25MP0010352_gastrointestinal_tract_polyps1.81147456
26* MP0003566_abnormal_cell_adhesion1.76354838
27MP0003283_abnormal_digestive_organ1.65283946
28MP0000678_abnormal_parathyroid_gland1.58644871
29MP0004264_abnormal_extraembryonic_tissu1.56373423
30MP0004957_abnormal_blastocyst_morpholog1.54077732
31* MP0009931_abnormal_skin_appearance1.43171000
32* MP0000367_abnormal_coat/_hair1.41476164
33MP0000462_abnormal_digestive_system1.35773506
34MP0004782_abnormal_surfactant_physiolog1.34710738
35MP0010030_abnormal_orbit_morphology1.32994807
36MP0002877_abnormal_melanocyte_morpholog1.31790822
37MP0001243_abnormal_dermal_layer1.31715046
38MP0009379_abnormal_foot_pigmentation1.29454086
39MP0005023_abnormal_wound_healing1.23743893
40MP0005377_hearing/vestibular/ear_phenot1.22023802
41MP0003878_abnormal_ear_physiology1.22023802
42MP0000537_abnormal_urethra_morphology1.22015952
43MP0003111_abnormal_nucleus_morphology1.21425828
44MP0004185_abnormal_adipocyte_glucose1.18424706
45MP0001346_abnormal_lacrimal_gland1.16266753
46MP0005451_abnormal_body_composition1.16156889
47* MP0001191_abnormal_skin_condition1.12718038
48MP0000566_synostosis1.09117937
49MP0004885_abnormal_endolymph1.05086459
50MP0008789_abnormal_olfactory_epithelium1.02514311
51MP0004019_abnormal_vitamin_homeostasis0.95749721
52MP0005076_abnormal_cell_differentiation0.94345266
53MP0003718_maternal_effect0.94323299
54* MP0000627_abnormal_mammary_gland0.85505486
55MP0001851_eye_inflammation0.84350027
56* MP0003755_abnormal_palate_morphology0.83798469
57MP0005257_abnormal_intraocular_pressure0.83484249
58MP0002282_abnormal_trachea_morphology0.83175306
59MP0004272_abnormal_basement_membrane0.82538655
60MP0009840_abnormal_foam_cell0.82097589
61* MP0002111_abnormal_tail_morphology0.81424599
62MP0001730_embryonic_growth_arrest0.80690905
63MP0000858_altered_metastatic_potential0.79930604
64MP0009780_abnormal_chondrocyte_physiolo0.77095861
65MP0008932_abnormal_embryonic_tissue0.76999511
66MP0005360_urolithiasis0.73591000
67MP0005367_renal/urinary_system_phenotyp0.73005666
68MP0000516_abnormal_urinary_system0.73005666
69MP0003077_abnormal_cell_cycle0.69628590
70MP0005499_abnormal_olfactory_system0.68365382
71MP0005394_taste/olfaction_phenotype0.68365382
72MP0000750_abnormal_muscle_regeneration0.65958813
73MP0008007_abnormal_cellular_replicative0.65832976
74* MP0000350_abnormal_cell_proliferation0.65628164
75MP0000465_gastrointestinal_hemorrhage0.64533003
76MP0000613_abnormal_salivary_gland0.63894001
77MP0004197_abnormal_fetal_growth/weight/0.63582982
78MP0003786_premature_aging0.63363018
79MP0000538_abnormal_urinary_bladder0.63324771
80MP0003806_abnormal_nucleotide_metabolis0.63074635
81MP0002095_abnormal_skin_pigmentation0.62185313
82* MP0001340_abnormal_eyelid_morphology0.60997491
83MP0008260_abnormal_autophagy0.60594571
84MP0001542_abnormal_bone_strength0.59977620
85MP0003866_abnormal_defecation0.59209397
86MP0005508_abnormal_skeleton_morphology0.59102098
87MP0000470_abnormal_stomach_morphology0.57958915
88MP0002086_abnormal_extraembryonic_tissu0.57380512
89MP0010094_abnormal_chromosome_stability0.57032620
90MP0001188_hyperpigmentation0.56530804
91* MP0000477_abnormal_intestine_morphology0.56296833
92MP0001784_abnormal_fluid_regulation0.55395797
93MP0002089_abnormal_postnatal_growth/wei0.54788790
94MP0003950_abnormal_plasma_membrane0.54358922
95MP0000490_abnormal_crypts_of0.53637533
96MP0001756_abnormal_urination0.53286488
97MP0003191_abnormal_cellular_cholesterol0.51458981
98MP0001672_abnormal_embryogenesis/_devel0.50893129
99MP0005380_embryogenesis_phenotype0.50893129
100MP0000003_abnormal_adipose_tissue0.50699184
101* MP0003937_abnormal_limbs/digits/tail_de0.50440723
102MP0005193_abnormal_anterior_eye0.49740775
103* MP0000432_abnormal_head_morphology0.49633648
104MP0005409_darkened_coat_color0.49339958
105* MP0002084_abnormal_developmental_patter0.46494842
106MP0010155_abnormal_intestine_physiology0.46264770
107* MP0002234_abnormal_pharynx_morphology0.46180828
108MP0002896_abnormal_bone_mineralization0.45923981
109MP0003045_fibrosis0.44243642
110MP0000733_abnormal_muscle_development0.44142565
111MP0000428_abnormal_craniofacial_morphol0.43488267
112* MP0009053_abnormal_anal_canal0.42982456
113MP0001299_abnormal_eye_distance/0.42356980
114MP0005197_abnormal_uvea_morphology0.42146635
115MP0002088_abnormal_embryonic_growth/wei0.42092980
116* MP0002085_abnormal_embryonic_tissue0.41974750
117MP0003119_abnormal_digestive_system0.41697449
118MP0003091_abnormal_cell_migration0.41477750
119MP0003385_abnormal_body_wall0.41299095
120MP0001697_abnormal_embryo_size0.41190099
121MP0003984_embryonic_growth_retardation0.41072287
122MP0003329_amyloid_beta_deposits0.40515579
123MP0005375_adipose_tissue_phenotype0.39736819
124MP0005248_abnormal_Harderian_gland0.39543707
125MP0003638_abnormal_response/metabolism_0.36639568
126MP0004043_abnormal_pH_regulation0.35854680
127* MP0002177_abnormal_outer_ear0.35497160
128MP0004858_abnormal_nervous_system0.34640362
129MP0001765_abnormal_ion_homeostasis0.33899854
130MP0005666_abnormal_adipose_tissue0.31688121
131MP0005083_abnormal_biliary_tract0.30410571
132MP0005075_abnormal_melanosome_morpholog0.30015432
133* MP0005621_abnormal_cell_physiology0.27167259
134MP0000013_abnormal_adipose_tissue0.26763264

Predicted human phenotypes

RankGene SetZ-score
1Fragile nails (HP:0001808)7.64543701
2Milia (HP:0001056)7.14757021
3Abnormality of nail color (HP:0100643)7.07429563
4Onycholysis (HP:0001806)6.61146895
5Plantar hyperkeratosis (HP:0007556)6.49212967
6Hypotrichosis (HP:0001006)6.38484037
7Pili torti (HP:0003777)6.21463936
8Thick nail (HP:0001805)6.18371394
9Woolly hair (HP:0002224)6.10137121
10Nail dystrophy (HP:0008404)5.50880742
11Palmoplantar hyperkeratosis (HP:0000972)5.37671201
12Palmar hyperkeratosis (HP:0010765)5.15771480
13Alopecia of scalp (HP:0002293)5.14331066
14Right ventricular cardiomyopathy (HP:0011663)4.68313022
15Ridged nail (HP:0001807)4.57976025
16Atrophic scars (HP:0001075)4.32272629
17Abnormal blistering of the skin (HP:0008066)4.17791074
18Oral leukoplakia (HP:0002745)4.02522400
19Increased IgE level (HP:0003212)4.02506502
20Congenital ichthyosiform erythroderma (HP:0007431)3.71437545
21Sparse eyelashes (HP:0000653)3.51179321
22Abnormal hair laboratory examination (HP:0003328)3.50833250
23Abnormality of the axillary hair (HP:0100134)3.40007620
24Abnormality of secondary sexual hair (HP:0009888)3.40007620
25Erythroderma (HP:0001019)3.27548371
26Abnormality of the salivary glands (HP:0010286)3.10777397
27Abnormality of placental membranes (HP:0011409)3.06038277
28Amniotic constriction ring (HP:0009775)3.06038277
29Blepharitis (HP:0000498)3.02538019
30Erythema (HP:0010783)2.97604995
31Pterygium (HP:0001059)2.95534133
32Follicular hyperkeratosis (HP:0007502)2.92402911
33Posterior subcapsular cataract (HP:0007787)2.86199832
34Breast hypoplasia (HP:0003187)2.83808766
35Popliteal pterygium (HP:0009756)2.81303041
36Brittle hair (HP:0002299)2.75319125
37Hypoplastic labia majora (HP:0000059)2.68154801
38Anonychia (HP:0001798)2.67691900
39Natal tooth (HP:0000695)2.62271088
40Dry hair (HP:0011359)2.60719319
41Abnormality of the neuromuscular junction (HP:0003398)2.53106782
42Fatigable weakness (HP:0003473)2.53106782
43Lip pit (HP:0100267)2.51874033
44Aplasia cutis congenita (HP:0001057)2.51115689
45Slow-growing hair (HP:0002217)2.49713569
46Abnormality of hair growth rate (HP:0011363)2.49713569
47Ankyloglossia (HP:0010296)2.48747638
48Oligodontia (HP:0000677)2.48499672
49Curly hair (HP:0002212)2.47416939
50Breech presentation (HP:0001623)2.46095896
51Flat acetabular roof (HP:0003180)2.43120259
52Abnormality of the labia majora (HP:0012881)2.41906116
53Abnormality of the distal phalanx of the thumb (HP:0009617)2.41845680
54Neonatal short-limb short stature (HP:0008921)2.38112601
55Symphalangism affecting the phalanges of the hand (HP:0009773)2.37502992
56Palmoplantar keratoderma (HP:0000982)2.34533201
57Ectropion (HP:0000656)2.32587609
58Esophageal atresia (HP:0002032)2.27848283
59Hypohidrosis (HP:0000966)2.26968038
60Trismus (HP:0000211)2.25837560
61Flat capital femoral epiphysis (HP:0003370)2.24839342
62Irregular epiphyses (HP:0010582)2.23523705
63Concave nail (HP:0001598)2.22706435
64Advanced eruption of teeth (HP:0006288)2.20786165
65Down-sloping shoulders (HP:0200021)2.20354095
66Abnormality of the proximal phalanges of the hand (HP:0009834)2.20060815
67Fragile skin (HP:0001030)2.14150655
68Ventricular tachycardia (HP:0004756)2.11602985
69Parakeratosis (HP:0001036)2.06266959
70Absent hair (HP:0002298)2.05332339
71Abnormality of the fingernails (HP:0001231)2.05326040
72Abnormality of the distal phalanges of the toes (HP:0010182)2.04292685
73Amelogenesis imperfecta (HP:0000705)2.04205393
74Corneal erosion (HP:0200020)2.04017414
75Axonal loss (HP:0003447)2.03841972
76Hypoplasia of dental enamel (HP:0006297)2.01567612
77Multifactorial inheritance (HP:0001426)2.01563190
78Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.00507964
79Congenital, generalized hypertrichosis (HP:0004540)2.00009829
80Abnormality of oral frenula (HP:0000190)1.98436619
81Hyperhidrosis (HP:0000975)1.98350617
82Absent phalangeal crease (HP:0006109)1.97184057
83Dehydration (HP:0001944)1.96656161
84Selective tooth agenesis (HP:0001592)1.95456274
85Distal lower limb muscle weakness (HP:0009053)1.95281364
86Sparse scalp hair (HP:0002209)1.91172672
87Corneal dystrophy (HP:0001131)1.90857576
88Ventricular fibrillation (HP:0001663)1.88428684
89Septate vagina (HP:0001153)1.88110745
90Pustule (HP:0200039)1.84237733
91Hypodontia (HP:0000668)1.82367418
92Abnormality of the 1st metacarpal (HP:0010009)1.82002534
93Increased connective tissue (HP:0009025)1.81911725
94Xerostomia (HP:0000217)1.79143886
95Autoamputation (HP:0001218)1.76524526
96Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.76401155
97Subcapsular cataract (HP:0000523)1.74416556
98Rough bone trabeculation (HP:0100670)1.73668776
99Carious teeth (HP:0000670)1.73012833
100Spinal cord compression (HP:0002176)1.72935554
101Nasolacrimal duct obstruction (HP:0000579)1.72263364
102Abnormal vertebral ossification (HP:0100569)1.72034618
103Abnormality of permanent molar morphology (HP:0011071)1.70185681
104Abnormality of the dental root (HP:0006486)1.70185681
105Taurodontia (HP:0000679)1.70185681
106Acanthosis nigricans (HP:0000956)1.69319545
107Epidermoid cyst (HP:0200040)1.68975847
108Skin ulcer (HP:0200042)1.67652855
109Squamous cell carcinoma (HP:0002860)1.67568411
110Muscle fiber splitting (HP:0003555)1.64917425
111Myopathic facies (HP:0002058)1.64823328
112Short phalanx of the thumb (HP:0009660)1.64778069
113Premature rupture of membranes (HP:0001788)1.63667371
114Split foot (HP:0001839)1.63608263
115Carpal bone hypoplasia (HP:0001498)1.63358135
116Neonatal onset (HP:0003623)1.63072101
117Cheilitis (HP:0100825)1.62938193
118Abnormality of the middle phalanges of the toes (HP:0010183)1.62889427
119Cupped ribs (HP:0000887)1.62384061
120Abnormality of the 2nd finger (HP:0004100)1.62316947
121Short middle phalanx of finger (HP:0005819)1.60942031
122Laryngomalacia (HP:0001601)1.59803905
123Labial hypoplasia (HP:0000066)1.58361816
124Abnormality of the umbilical cord (HP:0010881)1.57930581
125Areflexia of lower limbs (HP:0002522)1.57773287
126Absent eyelashes (HP:0000561)1.57071894
127Biliary tract neoplasm (HP:0100574)1.56808755
128Abnormal finger flexion creases (HP:0006143)1.56236086
129Abnormality of the gastric mucosa (HP:0004295)1.55643608
130Abnormality of molar (HP:0011077)1.55109982
131Abnormality of molar morphology (HP:0011070)1.55109982
132Conjunctival hamartoma (HP:0100780)1.55054870
133Short nail (HP:0001799)1.54451435
134Vertebral clefting (HP:0008428)1.53946096
135Stillbirth (HP:0003826)1.53058822
136Hypoplastic female external genitalia (HP:0012815)1.50776957
137Abnormality of the dental pulp (HP:0006479)1.45576161

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.87361181
2TAOK36.26280873
3EPHB23.56772709
4MAP3K33.12473021
5MST1R2.86977759
6BUB12.84979921
7SIK12.69807773
8TSSK62.52683647
9WEE12.41431787
10NME12.24471349
11TGFBR12.19723816
12RPS6KB22.17802772
13TAOK12.13417172
14NTRK12.07179470
15MAPKAPK31.93376577
16FER1.92459150
17MAP2K21.86591995
18RIPK11.86424628
19MAP3K61.86408747
20MST41.85380599
21SMG11.81061807
22LATS11.69216824
23NEK11.59251013
24PIM21.58870132
25LMTK21.50608666
26MAP3K21.48044842
27ZAK1.39988621
28PDGFRA1.38312680
29RPS6KA41.38066692
30MAP3K121.34820722
31FLT31.32454401
32PBK1.30759617
33PRKCI1.27156397
34TTK1.23446917
35STK101.18681424
36MET1.17709222
37STK38L1.15011649
38MAP3K111.14846548
39LATS21.13581808
40MAP3K81.09312040
41PLK41.08498244
42EPHA31.06715557
43AURKB1.06664068
44AKT31.04427745
45EPHB11.00590884
46KSR20.99786398
47PTK20.98609740
48TRIB30.97324537
49PIK3CA0.91826222
50EEF2K0.88360060
51ALK0.84000597
52TRPM70.82690838
53FGFR40.81761181
54TESK10.80687274
55MAP3K90.78688869
56PAK40.78624255
57PLK10.78049999
58ERN10.77413020
59TTN0.77254409
60PTK60.72340892
61STK240.72159325
62NEK20.72106121
63LRRK20.70804313
64MAP2K10.70331232
65ILK0.67904354
66PLK30.67595642
67PRPF4B0.66533846
68STK380.63082204
69FGFR10.62723107
70PRKD20.62373478
71MAPKAPK20.61818131
72PKN20.61448242
73PNCK0.61420480
74TESK20.60009127
75STK30.59854132
76PIK3CG0.59466896
77CDK70.59324783
78TGFBR20.58305001
79CDK60.58089627
80DYRK30.57109871
81RPS6KA20.56861642
82MAP3K130.56746860
83RAF10.56036586
84ERBB40.55653671
85ABL20.54415365
86PDK20.53722050
87NME20.52413579
88MAP3K10.52169119
89MTOR0.51446134
90MAP2K30.49099840
91MOS0.48156176
92PAK10.47793512
93CDK120.46422855
94ROCK20.46403642
95SIK30.45583475
96GRK60.45525440
97DDR20.44681692
98ARAF0.44437486
99AURKA0.44328783
100RPS6KA10.43309412
101PDGFRB0.42937347
102ERBB20.40465968
103SRPK10.39905039
104NEK60.39792968
105CSNK1E0.38931212
106MAP2K60.37951301
107NLK0.33944764
108BRSK20.32875112
109RET0.32519818
110IKBKB0.32194127
111GSK3A0.32140689
112KSR10.31919143
113EIF2AK10.31457443
114CDC42BPA0.30733759
115ICK0.30447849
116SGK4940.30247979
117SGK2230.30247979
118DMPK0.29230439
119DYRK20.28988084
120BRAF0.27807808
121PIM10.25941640
122IRAK30.24465859
123MELK0.23893805
124BMX0.23218470
125JAK30.22896056
126CHUK0.22760161
127CHEK10.22622303
128CDK40.22310008
129AKT20.20328953
130TAOK20.20069824
131PRKG20.19389678
132PAK20.19317641
133MAPKAPK50.19083832
134RPS6KB10.18582403
135CDK90.18437810
136ADRBK10.18045649
137RPS6KC10.17480544
138RPS6KL10.17480544
139MKNK10.16887502
140CAMK2G0.16166421
141CSNK2A10.15920658
142TYK20.15715662
143ROCK10.15448020
144PRKCD0.14502861

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.22825988
2RNA polymerase_Homo sapiens_hsa030203.10911885
3Ribosome_Homo sapiens_hsa030102.99736919
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.86354943
5Hedgehog signaling pathway_Homo sapiens_hsa043402.43136671
6Basal cell carcinoma_Homo sapiens_hsa052172.20612586
7RNA transport_Homo sapiens_hsa030132.12849035
8Hippo signaling pathway_Homo sapiens_hsa043901.93920163
9Tight junction_Homo sapiens_hsa045301.92349934
10Linoleic acid metabolism_Homo sapiens_hsa005911.87963253
11Vitamin B6 metabolism_Homo sapiens_hsa007501.86109643
12Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.68185786
13Mineral absorption_Homo sapiens_hsa049781.67529603
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.65359691
15ECM-receptor interaction_Homo sapiens_hsa045121.64230061
16* p53 signaling pathway_Homo sapiens_hsa041151.64134935
17Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.62581496
18Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.61684502
19ErbB signaling pathway_Homo sapiens_hsa040121.61672355
20Pentose phosphate pathway_Homo sapiens_hsa000301.59554834
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.59363529
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.55965871
23Adherens junction_Homo sapiens_hsa045201.53616695
24Steroid biosynthesis_Homo sapiens_hsa001001.51445485
25Small cell lung cancer_Homo sapiens_hsa052221.50861567
26Spliceosome_Homo sapiens_hsa030401.50087775
27GnRH signaling pathway_Homo sapiens_hsa049121.46219128
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.45904559
29Fat digestion and absorption_Homo sapiens_hsa049751.43932356
30Bladder cancer_Homo sapiens_hsa052191.42508189
31Pyrimidine metabolism_Homo sapiens_hsa002401.41569068
32Arachidonic acid metabolism_Homo sapiens_hsa005901.41510699
33Axon guidance_Homo sapiens_hsa043601.31866584
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.31699426
35Proteoglycans in cancer_Homo sapiens_hsa052051.28728016
36* Cell cycle_Homo sapiens_hsa041101.28126480
37Epstein-Barr virus infection_Homo sapiens_hsa051691.27194078
38Glycerophospholipid metabolism_Homo sapiens_hsa005641.27009412
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26383211
40Sulfur metabolism_Homo sapiens_hsa009201.23969344
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.22076067
42Fructose and mannose metabolism_Homo sapiens_hsa000511.20429779
43Pancreatic cancer_Homo sapiens_hsa052121.19751953
44Folate biosynthesis_Homo sapiens_hsa007901.19269245
45Glioma_Homo sapiens_hsa052141.18925020
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.18628949
47Regulation of autophagy_Homo sapiens_hsa041401.18444126
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15206034
49Thyroid cancer_Homo sapiens_hsa052161.15061635
50DNA replication_Homo sapiens_hsa030301.10351963
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08638876
52Acute myeloid leukemia_Homo sapiens_hsa052211.07968651
53Apoptosis_Homo sapiens_hsa042101.04977760
54Antigen processing and presentation_Homo sapiens_hsa046121.04250797
55Prion diseases_Homo sapiens_hsa050201.03211663
56Drug metabolism - other enzymes_Homo sapiens_hsa009831.01543661
57Insulin signaling pathway_Homo sapiens_hsa049101.00983685
58Toxoplasmosis_Homo sapiens_hsa051451.00195841
59Arginine biosynthesis_Homo sapiens_hsa002200.99032679
60Salmonella infection_Homo sapiens_hsa051320.98846627
61Glutathione metabolism_Homo sapiens_hsa004800.98703923
62Sulfur relay system_Homo sapiens_hsa041220.98410419
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97393115
64Amoebiasis_Homo sapiens_hsa051460.94478934
65MicroRNAs in cancer_Homo sapiens_hsa052060.92275649
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.91454462
67Hepatitis C_Homo sapiens_hsa051600.86142330
68TGF-beta signaling pathway_Homo sapiens_hsa043500.85966649
69Phenylalanine metabolism_Homo sapiens_hsa003600.85490048
70HTLV-I infection_Homo sapiens_hsa051660.82164303
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81385284
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81036935
73Mismatch repair_Homo sapiens_hsa034300.79841154
74Renin-angiotensin system_Homo sapiens_hsa046140.78904856
75Estrogen signaling pathway_Homo sapiens_hsa049150.78462013
76Inositol phosphate metabolism_Homo sapiens_hsa005620.78206192
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78089991
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77468055
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77050128
80Vitamin digestion and absorption_Homo sapiens_hsa049770.75722507
81Pathways in cancer_Homo sapiens_hsa052000.74438048
82Sphingolipid metabolism_Homo sapiens_hsa006000.71341796
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70961119
84Endometrial cancer_Homo sapiens_hsa052130.70276763
85VEGF signaling pathway_Homo sapiens_hsa043700.69953765
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68812651
87PI3K-Akt signaling pathway_Homo sapiens_hsa041510.68735232
88Chronic myeloid leukemia_Homo sapiens_hsa052200.68595336
89Focal adhesion_Homo sapiens_hsa045100.68231839
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.67473030
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.67471289
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66150699
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65244447
94Dilated cardiomyopathy_Homo sapiens_hsa054140.64080342
95TNF signaling pathway_Homo sapiens_hsa046680.63992057
96Base excision repair_Homo sapiens_hsa034100.63776860
97Fatty acid elongation_Homo sapiens_hsa000620.62706244
98Viral carcinogenesis_Homo sapiens_hsa052030.61842849
99Oocyte meiosis_Homo sapiens_hsa041140.61220768
100Dorso-ventral axis formation_Homo sapiens_hsa043200.60143927
101Renin secretion_Homo sapiens_hsa049240.58347472
102Long-term depression_Homo sapiens_hsa047300.58019828
103Ovarian steroidogenesis_Homo sapiens_hsa049130.56701879
104Legionellosis_Homo sapiens_hsa051340.56605326
105Non-small cell lung cancer_Homo sapiens_hsa052230.56502420
106Protein digestion and absorption_Homo sapiens_hsa049740.55955524
107HIF-1 signaling pathway_Homo sapiens_hsa040660.55045128
108Choline metabolism in cancer_Homo sapiens_hsa052310.53802332
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53343765
110Biosynthesis of amino acids_Homo sapiens_hsa012300.52872175
111Chemical carcinogenesis_Homo sapiens_hsa052040.52410464
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50734855
113Histidine metabolism_Homo sapiens_hsa003400.50573862
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49482830
115Renal cell carcinoma_Homo sapiens_hsa052110.49100853
116Wnt signaling pathway_Homo sapiens_hsa043100.49089097
117Nucleotide excision repair_Homo sapiens_hsa034200.47722716
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47644863
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46183239
120Galactose metabolism_Homo sapiens_hsa000520.45950794
121Rap1 signaling pathway_Homo sapiens_hsa040150.45720911
122Shigellosis_Homo sapiens_hsa051310.45544197
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45263598
124Purine metabolism_Homo sapiens_hsa002300.44941019
125Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44886287
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.44787460
127Ether lipid metabolism_Homo sapiens_hsa005650.44566502
128Tyrosine metabolism_Homo sapiens_hsa003500.44005721
129Vibrio cholerae infection_Homo sapiens_hsa051100.43376396
130Glucagon signaling pathway_Homo sapiens_hsa049220.42662474
131Arginine and proline metabolism_Homo sapiens_hsa003300.42125367
132Caffeine metabolism_Homo sapiens_hsa002320.41968782
133Prostate cancer_Homo sapiens_hsa052150.41877341
134Notch signaling pathway_Homo sapiens_hsa043300.41668416
135Ras signaling pathway_Homo sapiens_hsa040140.41562021
136Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41019410
137N-Glycan biosynthesis_Homo sapiens_hsa005100.40703943
138Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40678749
139Pertussis_Homo sapiens_hsa051330.40090853
140Influenza A_Homo sapiens_hsa051640.39584192
141Melanogenesis_Homo sapiens_hsa049160.39474712
142Melanoma_Homo sapiens_hsa052180.37845583
143Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37142439
144Homologous recombination_Homo sapiens_hsa034400.31691143
145Endocytosis_Homo sapiens_hsa041440.31203975
146Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30729314
147NF-kappa B signaling pathway_Homo sapiens_hsa040640.29277127

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