SFPQ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.70260732
2nuclear pore organization (GO:0006999)4.56104127
3mitotic sister chromatid cohesion (GO:0007064)4.50082959
4pre-miRNA processing (GO:0031054)4.37587666
5negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.24147958
6DNA unwinding involved in DNA replication (GO:0006268)4.23566849
7negative regulation of RNA splicing (GO:0033119)3.92595351
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.90563526
9protein localization to kinetochore (GO:0034501)3.82531609
10regulation of RNA export from nucleus (GO:0046831)3.81186247
11negative regulation of histone methylation (GO:0031061)3.80568890
12negative regulation of mRNA processing (GO:0050686)3.75417829
13RNA stabilization (GO:0043489)3.68361150
14mRNA stabilization (GO:0048255)3.68361150
15regulation of histone H3-K9 methylation (GO:0051570)3.60972137
16heterochromatin organization (GO:0070828)3.51570025
17pore complex assembly (GO:0046931)3.50739131
18regulation of sister chromatid cohesion (GO:0007063)3.47614018
19DNA topological change (GO:0006265)3.45518976
20DNA duplex unwinding (GO:0032508)3.45499423
21DNA geometric change (GO:0032392)3.43496378
22negative regulation of mRNA metabolic process (GO:1903312)3.43195548
23sister chromatid segregation (GO:0000819)3.40841831
24dosage compensation (GO:0007549)3.39152367
25protein localization to chromosome, centromeric region (GO:0071459)3.34608024
26glucocorticoid receptor signaling pathway (GO:0042921)3.34073445
27regulation of DNA endoreduplication (GO:0032875)3.33033350
28chromatin assembly (GO:0031497)3.31823428
29mitotic nuclear envelope disassembly (GO:0007077)3.27922095
30regulation of histone H3-K27 methylation (GO:0061085)3.23370875
31mitotic chromosome condensation (GO:0007076)3.20479419
32histone H3-K36 demethylation (GO:0070544)3.19733597
33chromosome condensation (GO:0030261)3.19717762
34mRNA splice site selection (GO:0006376)3.18990181
35regulation of centriole replication (GO:0046599)3.18266186
36regulation of NFAT protein import into nucleus (GO:0051532)3.16122224
37kinetochore organization (GO:0051383)3.14722257
38membrane disassembly (GO:0030397)3.10238105
39nuclear envelope disassembly (GO:0051081)3.10238105
40positive regulation of mitotic sister chromatid separation (GO:1901970)3.08353261
41positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.08353261
42positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.08353261
43regulation of mRNA stability (GO:0043488)3.07737742
44positive regulation of chromosome segregation (GO:0051984)3.07024437
45protein-DNA complex disassembly (GO:0032986)3.06340110
46nucleosome disassembly (GO:0006337)3.06340110
473-UTR-mediated mRNA stabilization (GO:0070935)3.03014508
48cytoplasmic mRNA processing body assembly (GO:0033962)2.99643165
49monoubiquitinated protein deubiquitination (GO:0035520)2.99386779
50regulation of nucleobase-containing compound transport (GO:0032239)2.99223254
51mitotic sister chromatid segregation (GO:0000070)2.98975092
52DNA synthesis involved in DNA repair (GO:0000731)2.98354968
53sister chromatid cohesion (GO:0007062)2.91194896
54DNA strand elongation (GO:0022616)2.89702780
55positive regulation of RNA splicing (GO:0033120)2.87827319
56positive regulation by host of viral transcription (GO:0043923)2.86304437
57regulation of RNA stability (GO:0043487)2.86144708
58RNA transport (GO:0050658)2.82998771
59establishment of RNA localization (GO:0051236)2.82998771
60nucleic acid transport (GO:0050657)2.82998771
61chromatin assembly or disassembly (GO:0006333)2.82606576
62negative regulation of histone modification (GO:0031057)2.81912955
63DNA conformation change (GO:0071103)2.81802709
64DNA packaging (GO:0006323)2.80289037
65* mRNA splicing, via spliceosome (GO:0000398)2.80129972
66* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.80129972
67positive regulation of cell cycle checkpoint (GO:1901978)2.79689568
68double-strand break repair via nonhomologous end joining (GO:0006303)2.79069685
69non-recombinational repair (GO:0000726)2.79069685
70regulation of centrosome cycle (GO:0046605)2.77985782
71spliceosomal tri-snRNP complex assembly (GO:0000244)2.77477328
72regulation of centrosome duplication (GO:0010824)2.77271907
73* RNA splicing, via transesterification reactions (GO:0000375)2.76603945
74negative regulation of histone acetylation (GO:0035067)2.76528983
75regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.76076703
76corticosteroid receptor signaling pathway (GO:0031958)2.76053017
77ATP-dependent chromatin remodeling (GO:0043044)2.75614931
78protein complex localization (GO:0031503)2.75382179
79protein localization to chromosome (GO:0034502)2.75282130
80histone H2B ubiquitination (GO:0033523)2.74852822
81stress granule assembly (GO:0034063)2.74844584
82regulation of DNA damage checkpoint (GO:2000001)2.73812060
83regulation of spindle organization (GO:0090224)2.73746949
84negative regulation of DNA repair (GO:0045738)2.73434179
85regulation of histone H3-K4 methylation (GO:0051569)2.71580275
86regulation of chromatin binding (GO:0035561)2.70569127
87protein export from nucleus (GO:0006611)2.69953512
88positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.68745969
89histone H3-K9 methylation (GO:0051567)2.68575816
90hematopoietic stem cell differentiation (GO:0060218)2.68538024
91paraxial mesoderm development (GO:0048339)2.68318953
92regulation of mitotic spindle organization (GO:0060236)2.68163653
93regulation of stem cell maintenance (GO:2000036)2.67744907
94histone H3-K4 methylation (GO:0051568)2.65520139
95mRNA transport (GO:0051028)2.65211933
96translesion synthesis (GO:0019985)2.64179661
97regulation of histone methylation (GO:0031060)2.63400483
98positive regulation of gene expression, epigenetic (GO:0045815)2.63329625
99nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.62654753
100DNA replication-dependent nucleosome assembly (GO:0006335)2.62607856
101DNA replication-dependent nucleosome organization (GO:0034723)2.62607856
102negative regulation of chromatin modification (GO:1903309)2.62390264
103histone H3-K4 trimethylation (GO:0080182)2.61240360
104mitotic metaphase plate congression (GO:0007080)2.60817691
105peptidyl-lysine dimethylation (GO:0018027)2.58133024
106histone H2A monoubiquitination (GO:0035518)2.58110111
107V(D)J recombination (GO:0033151)2.57119503
108termination of RNA polymerase II transcription (GO:0006369)2.56496474
109RNA export from nucleus (GO:0006405)2.55907858
110DNA replication initiation (GO:0006270)2.55618914
111negative regulation of translation, ncRNA-mediated (GO:0040033)2.55328513
112regulation of translation, ncRNA-mediated (GO:0045974)2.55328513
113negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.55328513
114peptidyl-lysine trimethylation (GO:0018023)2.54685285
115* alternative mRNA splicing, via spliceosome (GO:0000380)2.54100815
116negative regulation of gene expression, epigenetic (GO:0045814)2.53213152
117mRNA export from nucleus (GO:0006406)2.51302699
118regulation of posttranscriptional gene silencing (GO:0060147)2.51064181
119regulation of gene silencing by miRNA (GO:0060964)2.51064181
120regulation of gene silencing by RNA (GO:0060966)2.51064181
121DNA strand elongation involved in DNA replication (GO:0006271)2.50735072
122gene silencing by RNA (GO:0031047)2.50339387
123metaphase plate congression (GO:0051310)2.49780367
124nuclear envelope organization (GO:0006998)2.47826595
125DNA replication-independent nucleosome assembly (GO:0006336)2.47773884
126DNA replication-independent nucleosome organization (GO:0034724)2.47773884

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human5.91820113
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.75934377
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.13659539
4* MYC_22102868_ChIP-Seq_BL_Human3.53776240
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.21389722
6TP63_19390658_ChIP-ChIP_HaCaT_Human2.91954579
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.88024320
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.84819812
9* MYC_18555785_ChIP-Seq_MESCs_Mouse2.75147548
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.43260655
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.41417792
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.26513862
13* CIITA_25753668_ChIP-Seq_RAJI_Human2.05110653
14VDR_21846776_ChIP-Seq_THP-1_Human2.03972006
15E2F7_22180533_ChIP-Seq_HELA_Human10.0948947
16TCF7_22412390_ChIP-Seq_EML_Mouse1.96749132
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.95286137
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.82744430
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.78043347
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.76154191
21KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.72204257
22* AR_21909140_ChIP-Seq_LNCAP_Human1.68853682
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68135906
24ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68033496
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.63975043
26* KDM2B_26808549_Chip-Seq_DND41_Human1.60096978
27* XRN2_22483619_ChIP-Seq_HELA_Human1.58492042
28* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57643289
29* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.57234577
30* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55736408
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52147308
32PKCTHETA_26484144_Chip-Seq_BREAST_Human1.52067235
33SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.51710876
34SCL_19346495_ChIP-Seq_HPC-7_Human1.51599493
35HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.47330695
36SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.47107830
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47054469
38* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46802605
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.46486612
40CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.45336633
41UTX_26944678_Chip-Seq_JUKART_Human1.45109924
42ZFP281_27345836_Chip-Seq_ESCs_Mouse1.44787318
43KDM5A_27292631_Chip-Seq_BREAST_Human1.44083164
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.42409172
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37209024
46DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.32170564
47PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.31949174
48* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.31883436
49* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.30838685
50* MAF_26560356_Chip-Seq_TH1_Human1.28740448
51CLOCK_20551151_ChIP-Seq_293T_Human1.25361805
52* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25357373
53KDM2B_26808549_Chip-Seq_JURKAT_Human1.23140099
54* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23138845
55WT1_19549856_ChIP-ChIP_CCG9911_Human1.22715483
56* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22250545
57* TTF2_22483619_ChIP-Seq_HELA_Human1.20386914
58NANOG_21062744_ChIP-ChIP_HESCs_Human1.20312295
59* CHD1_26751641_Chip-Seq_LNCaP_Human1.20111054
60KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19300495
61KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19300495
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19300495
63EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17769344
64ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16670017
65* MYB_26560356_Chip-Seq_TH1_Human1.15645718
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15477798
67ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13469524
68* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12441163
69VDR_24763502_ChIP-Seq_THP-1_Human1.11889840
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11752526
71* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11707205
72* MYB_26560356_Chip-Seq_TH2_Human1.10743353
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08792139
74FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08289534
75* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08111863
76NCOR1_26117541_ChIP-Seq_K562_Human1.08009666
77* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07924150
78* ELK3_25401928_ChIP-Seq_HUVEC_Human1.07559399
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07141819
80* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07089908
81WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06047219
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03424604
83KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02744141
84* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.02349358
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99883721
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99181667
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99167988
88KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98169040
89ELK1_19687146_ChIP-ChIP_HELA_Human0.97553072
90* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97326708
91FOXP3_21729870_ChIP-Seq_TREG_Human0.97132029
92KDM2B_26808549_Chip-Seq_K562_Human0.95078755
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94551401
94STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.94176655
95TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93786061
96RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91251346
97* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90531637
98PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89889812
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89860798
100* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88740120
101SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88307799
102* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88051851
103* VDR_23849224_ChIP-Seq_CD4+_Human0.88032288
104ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87881491
105* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86794711
106POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86581093
107SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86495021
108* SOX2_16153702_ChIP-ChIP_HESCs_Human0.86383348
109TCF3_18692474_ChIP-Seq_MESCs_Mouse0.86192235
110TFEB_21752829_ChIP-Seq_HELA_Human0.84936555
111NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.84514448
112POU5F1_16518401_ChIP-PET_MESCs_Mouse0.83676458
113* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83423326
114STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.81921160
115TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81486071
116POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.76850278
117ISL1_27105846_Chip-Seq_CPCs_Mouse0.74720557
118* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.74696739
119* RING1B_27294783_Chip-Seq_NPCs_Mouse0.73275114

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.09984104
2MP0003111_abnormal_nucleus_morphology3.05379380
3MP0008057_abnormal_DNA_replication2.92000432
4MP0003077_abnormal_cell_cycle2.57067524
5MP0005076_abnormal_cell_differentiation2.56672587
6MP0003693_abnormal_embryo_hatching2.49924109
7MP0004957_abnormal_blastocyst_morpholog2.44685827
8MP0010352_gastrointestinal_tract_polyps2.40706904
9MP0002396_abnormal_hematopoietic_system2.17770590
10MP0008007_abnormal_cellular_replicative2.14581116
11MP0009278_abnormal_bone_marrow2.13674208
12MP0003123_paternal_imprinting2.10344517
13MP0004808_abnormal_hematopoietic_stem2.08049798
14MP0003121_genomic_imprinting2.02900444
15MP0000537_abnormal_urethra_morphology2.00474408
16MP0000350_abnormal_cell_proliferation1.94900231
17MP0010030_abnormal_orbit_morphology1.91872274
18MP0004197_abnormal_fetal_growth/weight/1.88624048
19MP0000569_abnormal_digit_pigmentation1.84728512
20MP0001730_embryonic_growth_arrest1.83493925
21MP0010307_abnormal_tumor_latency1.82571050
22MP0002084_abnormal_developmental_patter1.78674305
23MP0009053_abnormal_anal_canal1.73876731
24MP0004185_abnormal_adipocyte_glucose1.73352952
25MP0005380_embryogenesis_phenotype1.71470119
26MP0001672_abnormal_embryogenesis/_devel1.71470119
27MP0002085_abnormal_embryonic_tissue1.68424262
28MP0008058_abnormal_DNA_repair1.68329717
29MP0003567_abnormal_fetal_cardiomyocyte1.60788363
30MP0003705_abnormal_hypodermis_morpholog1.59453275
31MP0003984_embryonic_growth_retardation1.59025635
32MP0001697_abnormal_embryo_size1.58559942
33MP0002088_abnormal_embryonic_growth/wei1.57904863
34MP0003890_abnormal_embryonic-extraembry1.57296933
35MP0002086_abnormal_extraembryonic_tissu1.57030074
36MP0008877_abnormal_DNA_methylation1.54635561
37MP0001293_anophthalmia1.54308076
38MP0003787_abnormal_imprinting1.53823680
39MP0000733_abnormal_muscle_development1.52664593
40MP0001346_abnormal_lacrimal_gland1.45724178
41MP0006292_abnormal_olfactory_placode1.44555561
42MP0008932_abnormal_embryonic_tissue1.43993485
43MP0000703_abnormal_thymus_morphology1.38038740
44MP0009703_decreased_birth_body1.34927975
45MP0002080_prenatal_lethality1.33477007
46MP0000428_abnormal_craniofacial_morphol1.33209762
47MP0003937_abnormal_limbs/digits/tail_de1.26913051
48MP0003115_abnormal_respiratory_system1.26367994
49MP0000490_abnormal_crypts_of1.25759975
50MP0000566_synostosis1.24979533
51MP0003119_abnormal_digestive_system1.24509318
52MP0005397_hematopoietic_system_phenotyp1.24452689
53MP0001545_abnormal_hematopoietic_system1.24452689
54MP0003935_abnormal_craniofacial_develop1.23218658
55MP0001849_ear_inflammation1.22891794
56MP0003385_abnormal_body_wall1.22179649
57MP0002092_abnormal_eye_morphology1.20459465
58MP0003300_gastrointestinal_ulcer1.18896325
59MP0009672_abnormal_birth_weight1.17701897
60MP0003763_abnormal_thymus_physiology1.16403150
61MP0001188_hyperpigmentation1.15192826
62MP0000432_abnormal_head_morphology1.13159997
63MP0006054_spinal_hemorrhage1.12105433
64MP0002697_abnormal_eye_size1.11807688
65MP0002925_abnormal_cardiovascular_devel1.10437999
66MP0001915_intracranial_hemorrhage1.07710007
67MP0002398_abnormal_bone_marrow1.06026575
68MP0010234_abnormal_vibrissa_follicle1.04721389
69MP0000313_abnormal_cell_death1.03597318
70MP0002932_abnormal_joint_morphology1.02267638
71MP0003303_peritoneal_inflammation1.02090194
72MP0001286_abnormal_eye_development1.02010500
73MP0003861_abnormal_nervous_system1.00461610
74MP0002938_white_spotting0.96949863
75MP0003755_abnormal_palate_morphology0.96642072
76MP0005367_renal/urinary_system_phenotyp0.96639340
77MP0000516_abnormal_urinary_system0.96639340
78MP0003122_maternal_imprinting0.96067713
79MP0002111_abnormal_tail_morphology0.95264998
80MP0002019_abnormal_tumor_incidence0.94131914
81MP0008961_abnormal_basal_metabolism0.93888542
82MP0002233_abnormal_nose_morphology0.92071778
83MP0002116_abnormal_craniofacial_bone0.90273241
84MP0003786_premature_aging0.89336391
85MP0005409_darkened_coat_color0.88183877
86MP0000049_abnormal_middle_ear0.87969574
87MP0003942_abnormal_urinary_system0.87891077
88MP0001299_abnormal_eye_distance/0.86819574
89MP0005621_abnormal_cell_physiology0.86760420
90MP0004264_abnormal_extraembryonic_tissu0.86443035
91MP0003315_abnormal_perineum_morphology0.86301784
92MP0000778_abnormal_nervous_system0.85505193
93MP0002722_abnormal_immune_system0.85367076
94MP0002114_abnormal_axial_skeleton0.85212496
95MP0002249_abnormal_larynx_morphology0.84804359
96MP0002009_preneoplasia0.84172128
97MP0002166_altered_tumor_susceptibility0.83664845
98MP0003943_abnormal_hepatobiliary_system0.82399096
99MP0003566_abnormal_cell_adhesion0.82109474
100MP0003091_abnormal_cell_migration0.80042217
101MP0002877_abnormal_melanocyte_morpholog0.79297992
102MP0002282_abnormal_trachea_morphology0.79254925
103MP0005623_abnormal_meninges_morphology0.78969234
104MP0005187_abnormal_penis_morphology0.78802329
105MP0002081_perinatal_lethality0.78795557
106MP0001784_abnormal_fluid_regulation0.78279891
107MP0000383_abnormal_hair_follicle0.77913074
108MP0010678_abnormal_skin_adnexa0.77163351
109MP0008770_decreased_survivor_rate0.77121057
110MP0010630_abnormal_cardiac_muscle0.77088529
111MP0009697_abnormal_copulation0.76291170
112MP0003938_abnormal_ear_development0.75596494
113MP0003941_abnormal_skin_development0.74359682
114MP0005220_abnormal_exocrine_pancreas0.74305052
115MP0001340_abnormal_eyelid_morphology0.74282031
116MP0005666_abnormal_adipose_tissue0.73210156
117MP0003221_abnormal_cardiomyocyte_apopto0.73103208
118MP0009250_abnormal_appendicular_skeleto0.72222447
119MP0000266_abnormal_heart_morphology0.72197567
120MP0000689_abnormal_spleen_morphology0.72069194
121MP0002089_abnormal_postnatal_growth/wei0.69410569
122MP0005384_cellular_phenotype0.69333492
123MP0000534_abnormal_ureter_morphology0.67782978

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.54928512
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.54928512
3Volvulus (HP:0002580)3.30513555
4Abnormality of the fingertips (HP:0001211)3.10335646
5Increased nuchal translucency (HP:0010880)2.94731005
6Hyperacusis (HP:0010780)2.93075932
7Birth length less than 3rd percentile (HP:0003561)2.66955946
8Medulloblastoma (HP:0002885)2.66807201
9Renal duplication (HP:0000075)2.66590689
10Abnormality of the 4th metacarpal (HP:0010012)2.62354877
11Long eyelashes (HP:0000527)2.58513104
12Proximal placement of thumb (HP:0009623)2.43773266
13Supernumerary ribs (HP:0005815)2.42720812
14Abnormality of the distal phalanx of the thumb (HP:0009617)2.39673644
15Nephroblastoma (Wilms tumor) (HP:0002667)2.39440439
16Deviation of the thumb (HP:0009603)2.37813849
17Ependymoma (HP:0002888)2.32824451
18Deep palmar crease (HP:0006191)2.31248145
19Abnormal number of incisors (HP:0011064)2.30654942
20Trigonocephaly (HP:0000243)2.30029401
21Colon cancer (HP:0003003)2.28407698
22Spinal cord lesions (HP:0100561)2.26817158
23Syringomyelia (HP:0003396)2.26817158
24Ectopic kidney (HP:0000086)2.25508009
25Missing ribs (HP:0000921)2.23256111
26Cortical dysplasia (HP:0002539)2.22676921
27Embryonal renal neoplasm (HP:0011794)2.21559041
28Heterotopia (HP:0002282)2.19941117
29Supernumerary bones of the axial skeleton (HP:0009144)2.19297903
30Renovascular hypertension (HP:0100817)2.18148657
31Selective tooth agenesis (HP:0001592)2.17900327
32Elfin facies (HP:0004428)2.14198109
33Hepatoblastoma (HP:0002884)2.13280536
34Dysmetric saccades (HP:0000641)2.12540613
35Neoplasm of the oral cavity (HP:0100649)2.10483477
36Increased density of long bones (HP:0006392)2.08328886
37Overriding aorta (HP:0002623)2.07689360
38Macroorchidism (HP:0000053)2.07422013
39Broad palm (HP:0001169)2.05871982
40Abnormality of the astrocytes (HP:0100707)2.04915916
41Astrocytoma (HP:0009592)2.04915916
42Shallow orbits (HP:0000586)2.04243496
43Chromsome breakage (HP:0040012)2.03046489
44Asymmetry of the thorax (HP:0001555)2.02522836
45Abnormality of the phalanges of the hallux (HP:0010057)2.01117981
46Deep philtrum (HP:0002002)1.98781708
47Chin dimple (HP:0010751)1.98199514
4811 pairs of ribs (HP:0000878)1.96832170
49Skin tags (HP:0010609)1.96751107
50Gastrointestinal carcinoma (HP:0002672)1.96269514
51Malignant gastrointestinal tract tumors (HP:0006749)1.96269514
52Neonatal hypoglycemia (HP:0001998)1.96134387
53Atresia of the external auditory canal (HP:0000413)1.95405737
54Broad thumb (HP:0011304)1.94924997
55Obsessive-compulsive behavior (HP:0000722)1.94066902
56Cutis marmorata (HP:0000965)1.92999711
57Radioulnar synostosis (HP:0002974)1.92563541
58Basal cell carcinoma (HP:0002671)1.92544044
59Abnormality of the parietal bone (HP:0002696)1.91535109
60Pseudobulbar signs (HP:0002200)1.91272702
61Facial hemangioma (HP:0000329)1.90973979
62Arnold-Chiari malformation (HP:0002308)1.90968875
63Skull defect (HP:0001362)1.90891754
64Narrow palate (HP:0000189)1.89929159
65Prominent nose (HP:0000448)1.89779813
66Neoplasm of striated muscle (HP:0009728)1.89691619
67Diastasis recti (HP:0001540)1.86493915
68Rhabdomyosarcoma (HP:0002859)1.86277179
69Subacute progressive viral hepatitis (HP:0006572)1.85536002
70Urethral obstruction (HP:0000796)1.85259963
71Patellar aplasia (HP:0006443)1.83534031
72Cafe-au-lait spot (HP:0000957)1.83456249
73Absent radius (HP:0003974)1.83041566
74Chromosomal breakage induced by crosslinking agents (HP:0003221)1.81920908
75Abnormality of the diencephalon (HP:0010662)1.81816129
76Glioma (HP:0009733)1.80845988
77High pitched voice (HP:0001620)1.80631807
78Flat cornea (HP:0007720)1.80392005
79Partial agenesis of the corpus callosum (HP:0001338)1.79422293
80Insomnia (HP:0100785)1.79400201
81Pointed chin (HP:0000307)1.79101606
82Overlapping toe (HP:0001845)1.78124925
83Ankyloglossia (HP:0010296)1.77070232
84Absent frontal sinuses (HP:0002688)1.75101074
85Aplasia/Hypoplasia of the patella (HP:0006498)1.75084087
86Bowel diverticulosis (HP:0005222)1.75020474
87Abnormality of the incisor (HP:0000676)1.74768729
88Sparse lateral eyebrow (HP:0005338)1.74514505
89Abnormality of the labia minora (HP:0012880)1.73924122
90Aqueductal stenosis (HP:0002410)1.73459377
91Low anterior hairline (HP:0000294)1.73293243
92Abnormality of the calcaneus (HP:0008364)1.73285141
93Acute myeloid leukemia (HP:0004808)1.72999616
94Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.72502953
95Protruding tongue (HP:0010808)1.72174066
96Short phalanx of the thumb (HP:0009660)1.71836288
97Neoplasm of the adrenal cortex (HP:0100641)1.69750414
98Broad phalanges of the hand (HP:0009768)1.69325021
99Preauricular skin tag (HP:0000384)1.69266980
100Germ cell neoplasia (HP:0100728)1.69182088
101Rib fusion (HP:0000902)1.69103648
102Transitional cell carcinoma of the bladder (HP:0006740)1.68675288
103Relative macrocephaly (HP:0004482)1.68608463
104High anterior hairline (HP:0009890)1.68598595
105Acute lymphatic leukemia (HP:0006721)1.68160142
106Esophageal atresia (HP:0002032)1.68065523
107Truncal obesity (HP:0001956)1.67967495
108Anal stenosis (HP:0002025)1.67946339
109Abnormality of chromosome stability (HP:0003220)1.67278245
110Broad finger (HP:0001500)1.66307889
111Aplasia/Hypoplasia of the sternum (HP:0006714)1.65876096
112Abnormality of chromosome segregation (HP:0002916)1.65787605
113Bladder carcinoma (HP:0002862)1.65513273
114Bladder neoplasm (HP:0009725)1.65513273
115Hypoplasia of the maxilla (HP:0000327)1.65445551
116Aplasia involving forearm bones (HP:0009822)1.64813529
117Absent forearm bone (HP:0003953)1.64813529
118Sacral dimple (HP:0000960)1.64583408
119Short 5th finger (HP:0009237)1.64429543
120Embryonal neoplasm (HP:0002898)1.63846583
121Disproportionate tall stature (HP:0001519)1.63823204
122Large earlobe (HP:0009748)1.63708375
123Smooth philtrum (HP:0000319)1.63415031
124Midline defect of the nose (HP:0004122)1.63182351
125Uterine leiomyosarcoma (HP:0002891)1.62982672
126Leiomyosarcoma (HP:0100243)1.62982672
127Myelodysplasia (HP:0002863)1.62471734
128Abnormality of the carotid arteries (HP:0005344)1.61832121
129Short middle phalanx of finger (HP:0005819)1.61287335
130Abnormality of the intervertebral disk (HP:0005108)1.61172058
131Sandal gap (HP:0001852)1.61115624
132Short 1st metacarpal (HP:0010034)1.60005450
133Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.60005450
134Rectal prolapse (HP:0002035)1.60004141
135Vertebral arch anomaly (HP:0008438)1.59465353
136Deviation of the hallux (HP:0010051)1.58568066
137Spina bifida occulta (HP:0003298)1.58421383
138Dislocated radial head (HP:0003083)1.58090965

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.93060885
2BRD43.86048661
3CDC73.85509505
4MAP3K103.47886701
5EEF2K3.30672681
6SMG12.69890709
7NEK22.53623969
8PKN22.30912782
9SRPK11.92155466
10CDK61.90434348
11RPS6KB21.82392528
12PRPF4B1.78882540
13CDK41.78338243
14TRIB31.74343881
15LATS11.71914698
16ATR1.67473755
17PASK1.63044951
18STK101.61996570
19TSSK61.56098270
20WEE11.53057955
21TTK1.50656705
22SIK21.45412863
23TAF11.42044033
24PTK61.41616089
25CDK71.39246368
26CHEK11.37942635
27CDK91.34916859
28MTOR1.32143637
29STK31.28208583
30ICK1.28046169
31CAMK1G1.27968143
32MAP4K11.27573309
33RPS6KA41.27200696
34PLK41.23575175
35TGFBR11.19020704
36PNCK1.16896345
37ATM1.15941516
38STK41.15513145
39PLK11.11165371
40DYRK31.10327571
41MAP3K81.09999073
42AURKB1.09243911
43CAMK1D1.08753410
44CHEK21.08016393
45CDK21.06357284
46TNIK1.06203479
47PAK41.03707546
48CLK11.03301959
49FGFR41.00352205
50RIPK10.97881401
51AKT30.97314373
52* MKNK10.94509068
53PLK30.93029925
54* ALK0.92913062
55SCYL20.92774942
56FGFR30.91899386
57PDGFRA0.90204170
58PIM10.89466604
59ERBB30.87840762
60FGFR10.86985413
61PAK20.86599132
62CDK10.82450609
63CDK30.82285337
64CHUK0.80517299
65MELK0.80345222
66MAP3K140.77260604
67LRRK20.76305924
68DMPK0.75399470
69PDGFRB0.73569015
70FGFR20.73051479
71PRKDC0.69411098
72MAPK140.68782808
73BMX0.68641156
74HIPK20.67958666
75CSNK1D0.65729251
76EIF2AK20.64996868
77NLK0.64212036
78CSNK1A1L0.62468375
79BTK0.61228071
80BUB10.60054799
81BRSK20.59628514
82TYRO30.59464257
83UHMK10.58487985
84CSNK1E0.58215565
85TTN0.56612360
86AKT10.55149707
87MAPK10.53143438
88GRK60.52460978
89STK240.51350253
90* GSK3B0.51198701
91KSR10.50506181
92MAP2K20.49590580
93ACVR1B0.49480582
94WNK10.49008058
95CDK80.48011980
96EPHB20.47728540
97DYRK1B0.47216676
98SGK20.47178211
99ERBB20.45440911
100MAP3K90.45347615
101RPS6KA10.42552307
102MAPK80.42218755
103CSF1R0.41688288
104STK38L0.41077035
105CSNK2A20.40528966
106MARK20.40046427
107DYRK1A0.39986375
108BRSK10.39933353
109MAPK90.39609717
110HCK0.39566629
111JAK30.38968932
112AKT20.38878370
113TAOK10.37662731
114RET0.37344196
115MARK30.37129282
116LATS20.36253322
117MAPK110.35922231
118YES10.35610715
119ITK0.35079830
120SIK10.34987534
121MAPK100.34984392
122SGK30.33312022
123IRAK20.32642527
124RPS6KC10.32292439
125RPS6KL10.32292439
126MAP3K130.31894227
127RPS6KB10.30812898

Predicted pathways (KEGG)

RankGene SetZ-score
1Spliceosome_Homo sapiens_hsa030402.69589328
2DNA replication_Homo sapiens_hsa030302.67538360
3Mismatch repair_Homo sapiens_hsa034302.41152715
4mRNA surveillance pathway_Homo sapiens_hsa030152.36291213
5Cell cycle_Homo sapiens_hsa041102.32522054
6RNA transport_Homo sapiens_hsa030132.23783932
7Base excision repair_Homo sapiens_hsa034101.85703536
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.80769480
9Chronic myeloid leukemia_Homo sapiens_hsa052201.72391113
10MicroRNAs in cancer_Homo sapiens_hsa052061.70228658
11Non-homologous end-joining_Homo sapiens_hsa034501.58273583
12Homologous recombination_Homo sapiens_hsa034401.53902096
13Basal cell carcinoma_Homo sapiens_hsa052171.53352799
14Nucleotide excision repair_Homo sapiens_hsa034201.50526295
15Fanconi anemia pathway_Homo sapiens_hsa034601.50387478
16Transcriptional misregulation in cancer_Homo sapiens_hsa052021.46547638
17Notch signaling pathway_Homo sapiens_hsa043301.46427142
18Colorectal cancer_Homo sapiens_hsa052101.46364620
19One carbon pool by folate_Homo sapiens_hsa006701.44807436
20Small cell lung cancer_Homo sapiens_hsa052221.41145066
21HTLV-I infection_Homo sapiens_hsa051661.36094256
22RNA degradation_Homo sapiens_hsa030181.35692761
23Lysine degradation_Homo sapiens_hsa003101.34223273
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.26128492
25Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.26016708
26Herpes simplex infection_Homo sapiens_hsa051681.25683632
27Viral carcinogenesis_Homo sapiens_hsa052031.24033158
28Hippo signaling pathway_Homo sapiens_hsa043901.23941461
29Adherens junction_Homo sapiens_hsa045201.23047596
30p53 signaling pathway_Homo sapiens_hsa041151.21532119
31B cell receptor signaling pathway_Homo sapiens_hsa046621.18522009
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.17810715
33Endometrial cancer_Homo sapiens_hsa052131.16492876
34Non-small cell lung cancer_Homo sapiens_hsa052231.14234744
35Primary immunodeficiency_Homo sapiens_hsa053401.13407829
36Viral myocarditis_Homo sapiens_hsa054161.12417105
37Antigen processing and presentation_Homo sapiens_hsa046121.12357487
38Prostate cancer_Homo sapiens_hsa052151.09273760
39Acute myeloid leukemia_Homo sapiens_hsa052211.07337823
40mTOR signaling pathway_Homo sapiens_hsa041501.07002621
41TGF-beta signaling pathway_Homo sapiens_hsa043501.06915989
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.06776006
43Hedgehog signaling pathway_Homo sapiens_hsa043401.06396820
44Proteoglycans in cancer_Homo sapiens_hsa052051.06325961
45Longevity regulating pathway - mammal_Homo sapiens_hsa042111.05738275
46Wnt signaling pathway_Homo sapiens_hsa043101.05266746
47Pancreatic cancer_Homo sapiens_hsa052121.04636472
48Epstein-Barr virus infection_Homo sapiens_hsa051691.02995356
49Hepatitis B_Homo sapiens_hsa051611.01675479
50Thyroid cancer_Homo sapiens_hsa052161.01496394
51T cell receptor signaling pathway_Homo sapiens_hsa046601.00225166
52Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98495169
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97967052
54Choline metabolism in cancer_Homo sapiens_hsa052310.96740782
55Basal transcription factors_Homo sapiens_hsa030220.96724166
56Oocyte meiosis_Homo sapiens_hsa041140.96263595
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95185840
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.94155448
59Pathways in cancer_Homo sapiens_hsa052000.92532252
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92305159
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90827860
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.90626356
63Glioma_Homo sapiens_hsa052140.83338676
64Ribosome_Homo sapiens_hsa030100.83010288
65Measles_Homo sapiens_hsa051620.81271849
66Systemic lupus erythematosus_Homo sapiens_hsa053220.78734978
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.78268710
68Focal adhesion_Homo sapiens_hsa045100.77688316
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75290047
70Apoptosis_Homo sapiens_hsa042100.75079284
71Inositol phosphate metabolism_Homo sapiens_hsa005620.74910302
72Osteoclast differentiation_Homo sapiens_hsa043800.74908527
73FoxO signaling pathway_Homo sapiens_hsa040680.74801652
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74764206
75Dorso-ventral axis formation_Homo sapiens_hsa043200.72923182
76Bladder cancer_Homo sapiens_hsa052190.72902126
77Renal cell carcinoma_Homo sapiens_hsa052110.72498563
78Toxoplasmosis_Homo sapiens_hsa051450.72222941
79Platelet activation_Homo sapiens_hsa046110.68870394
80Long-term potentiation_Homo sapiens_hsa047200.68458412
81Melanogenesis_Homo sapiens_hsa049160.67340466
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.67135847
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.66337556
84Shigellosis_Homo sapiens_hsa051310.65994775
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65539796
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63756678
87Influenza A_Homo sapiens_hsa051640.62991003
88Insulin signaling pathway_Homo sapiens_hsa049100.61942640
89Leishmaniasis_Homo sapiens_hsa051400.61543093
90Prolactin signaling pathway_Homo sapiens_hsa049170.61438316
91Selenocompound metabolism_Homo sapiens_hsa004500.61244284
92ErbB signaling pathway_Homo sapiens_hsa040120.60908030
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60516979
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.60189321
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59105370
96VEGF signaling pathway_Homo sapiens_hsa043700.58899706
97Hematopoietic cell lineage_Homo sapiens_hsa046400.58376689
98Melanoma_Homo sapiens_hsa052180.57890597
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57157669
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57092808
101RNA polymerase_Homo sapiens_hsa030200.56893879
102Type II diabetes mellitus_Homo sapiens_hsa049300.56731578
103Tight junction_Homo sapiens_hsa045300.56707005
104TNF signaling pathway_Homo sapiens_hsa046680.56669908
105Estrogen signaling pathway_Homo sapiens_hsa049150.56499954
106ECM-receptor interaction_Homo sapiens_hsa045120.54318331
107Chemokine signaling pathway_Homo sapiens_hsa040620.54291308
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53096038
109MAPK signaling pathway_Homo sapiens_hsa040100.53051860
110AMPK signaling pathway_Homo sapiens_hsa041520.51844573
111HIF-1 signaling pathway_Homo sapiens_hsa040660.51474049
112Alcoholism_Homo sapiens_hsa050340.50956988
113Axon guidance_Homo sapiens_hsa043600.50840863
114GnRH signaling pathway_Homo sapiens_hsa049120.47222809
115Hepatitis C_Homo sapiens_hsa051600.45562721
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42796847
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.40666276
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39947716
119Gap junction_Homo sapiens_hsa045400.39827294
120Rap1 signaling pathway_Homo sapiens_hsa040150.37313618
121Prion diseases_Homo sapiens_hsa050200.34643564

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