SFR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)4.53900740
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.43529140
3mitotic metaphase plate congression (GO:0007080)4.24422291
4cullin deneddylation (GO:0010388)4.19800738
5protein deneddylation (GO:0000338)4.13734778
6energy coupled proton transport, down electrochemical gradient (GO:0015985)4.09667513
7ATP synthesis coupled proton transport (GO:0015986)4.09667513
8protein complex biogenesis (GO:0070271)4.07551916
9nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.05469846
10exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.02398832
11DNA deamination (GO:0045006)4.02107206
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.96970414
13mitochondrial respiratory chain complex I assembly (GO:0032981)3.96970414
14NADH dehydrogenase complex assembly (GO:0010257)3.96970414
15respiratory chain complex IV assembly (GO:0008535)3.89891013
16establishment of integrated proviral latency (GO:0075713)3.88936179
17mitochondrial respiratory chain complex assembly (GO:0033108)3.87716851
18maturation of SSU-rRNA (GO:0030490)3.79784213
19protein neddylation (GO:0045116)3.78509984
20ribosomal small subunit assembly (GO:0000028)3.78482106
21metaphase plate congression (GO:0051310)3.75150479
22formation of translation preinitiation complex (GO:0001731)3.74595612
23DNA replication initiation (GO:0006270)3.74476136
24chaperone-mediated protein transport (GO:0072321)3.73522469
25DNA strand elongation involved in DNA replication (GO:0006271)3.70922535
26proteasome assembly (GO:0043248)3.69110236
27CENP-A containing nucleosome assembly (GO:0034080)3.69092826
28DNA unwinding involved in DNA replication (GO:0006268)3.67484809
29ribosomal small subunit biogenesis (GO:0042274)3.65633525
30DNA double-strand break processing (GO:0000729)3.65196181
31platelet dense granule organization (GO:0060155)3.64929751
32attachment of spindle microtubules to kinetochore (GO:0008608)3.64506250
33chromatin remodeling at centromere (GO:0031055)3.61348717
34DNA replication checkpoint (GO:0000076)3.59671054
35mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.58924723
36negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.56368075
37synapsis (GO:0007129)3.55951539
38DNA strand elongation (GO:0022616)3.54106632
39anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.51661051
40cytochrome complex assembly (GO:0017004)3.46427312
41kinetochore organization (GO:0051383)3.45484001
42rRNA modification (GO:0000154)3.45223004
43replication fork processing (GO:0031297)3.45177285
44regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.42627443
45tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.41988750
46RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.41988750
47positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.41920915
48DNA replication-dependent nucleosome organization (GO:0034723)3.40552383
49DNA replication-dependent nucleosome assembly (GO:0006335)3.40552383
50DNA catabolic process, exonucleolytic (GO:0000738)3.39985390
51translational termination (GO:0006415)3.39863819
52establishment of chromosome localization (GO:0051303)3.38815260
53ribosomal large subunit biogenesis (GO:0042273)3.38507850
54viral transcription (GO:0019083)3.38431188
55telomere maintenance via semi-conservative replication (GO:0032201)3.36851578
56negative regulation of ligase activity (GO:0051352)3.32708375
57negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.32708375
58ribosome assembly (GO:0042255)3.29226465
59telomere maintenance via recombination (GO:0000722)3.28374358
60negative regulation of DNA-dependent DNA replication (GO:2000104)3.27193439
61water-soluble vitamin biosynthetic process (GO:0042364)3.25680731
62protein localization to kinetochore (GO:0034501)3.24695841
63regulation of meiosis I (GO:0060631)3.21719180
64respiratory electron transport chain (GO:0022904)3.20391492
65DNA replication-independent nucleosome organization (GO:0034724)3.17621909
66DNA replication-independent nucleosome assembly (GO:0006336)3.17621909
67translational initiation (GO:0006413)3.17207262
68mitotic recombination (GO:0006312)3.17081169
69electron transport chain (GO:0022900)3.16719054
707-methylguanosine mRNA capping (GO:0006370)3.16290390
71regulation of mitotic spindle checkpoint (GO:1903504)3.14768495
72regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.14768495
73establishment of viral latency (GO:0019043)3.14605251
74regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.13569282
75RNA capping (GO:0036260)3.12404858
767-methylguanosine RNA capping (GO:0009452)3.12404858
77negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.10561411
78spindle checkpoint (GO:0031577)3.10519260
79kinetochore assembly (GO:0051382)3.09355020
80ribonucleoprotein complex biogenesis (GO:0022613)3.09092065
81regulation of spindle organization (GO:0090224)3.08199546
82purine nucleobase biosynthetic process (GO:0009113)3.06949981
83protein K6-linked ubiquitination (GO:0085020)3.06572381
84SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.05242174
85negative regulation of mitotic sister chromatid separation (GO:2000816)3.04919628
86negative regulation of mitotic sister chromatid segregation (GO:0033048)3.04919628
87negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.04919628
88negative regulation of sister chromatid segregation (GO:0033046)3.04919628
89positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.04916873
90cotranslational protein targeting to membrane (GO:0006613)3.04822065
91mitotic nuclear envelope disassembly (GO:0007077)3.04767369
92translational elongation (GO:0006414)3.04631862
93mitotic spindle assembly checkpoint (GO:0007094)3.03645106
94maturation of 5.8S rRNA (GO:0000460)3.03446441
95mitotic spindle checkpoint (GO:0071174)3.02893695
96regulation of cellular amino acid metabolic process (GO:0006521)3.02149634
97transcription-coupled nucleotide-excision repair (GO:0006283)3.02100436
98maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.01508964
99mitotic chromosome condensation (GO:0007076)3.00345913
100negative regulation of chromosome segregation (GO:0051985)3.00026439
101protein targeting to ER (GO:0045047)2.99742002
102piRNA metabolic process (GO:0034587)2.99163087
103DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.98889984
104histone exchange (GO:0043486)2.98592592
105spindle assembly checkpoint (GO:0071173)2.98242174
106termination of RNA polymerase III transcription (GO:0006386)2.97348106
107transcription elongation from RNA polymerase III promoter (GO:0006385)2.97348106
108nucleobase biosynthetic process (GO:0046112)2.95476517
109protein-cofactor linkage (GO:0018065)2.94543672
110RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.94371383
111intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.93927155
112signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.93927155
113spliceosomal complex assembly (GO:0000245)2.92888722
114regulation of mitochondrial translation (GO:0070129)2.92675275
115nucleotide-excision repair, DNA gap filling (GO:0006297)2.92645622
116regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.92394558
117cell cycle G1/S phase transition (GO:0044843)2.92321689
118G1/S transition of mitotic cell cycle (GO:0000082)2.92321689
119positive regulation of ligase activity (GO:0051351)2.91575974
120spliceosomal snRNP assembly (GO:0000387)2.89722631
121signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.89548274
122signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.89548274
123signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.89548274
124transcription elongation from RNA polymerase I promoter (GO:0006362)2.89363043
125resolution of meiotic recombination intermediates (GO:0000712)2.89048385
126rRNA processing (GO:0006364)2.88696697
127nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.88028760
128telomere maintenance via telomere lengthening (GO:0010833)2.87834963
129mitotic sister chromatid segregation (GO:0000070)2.87723745
130regulation of mitotic metaphase/anaphase transition (GO:0030071)2.87642333
131signal transduction involved in DNA integrity checkpoint (GO:0072401)2.87183952
132signal transduction involved in DNA damage checkpoint (GO:0072422)2.87183952
133regulation of helicase activity (GO:0051095)2.85866995
134rRNA methylation (GO:0031167)2.85557259
135establishment of protein localization to endoplasmic reticulum (GO:0072599)2.85049608
136protein localization to endoplasmic reticulum (GO:0070972)2.84613485
137intracellular protein transmembrane import (GO:0044743)2.84417649
138regulation of mitotic spindle organization (GO:0060236)2.84093726
139membrane disassembly (GO:0030397)2.83515547
140nuclear envelope disassembly (GO:0051081)2.83515547
141somatic hypermutation of immunoglobulin genes (GO:0016446)2.83387642
142somatic diversification of immune receptors via somatic mutation (GO:0002566)2.83387642
143inner mitochondrial membrane organization (GO:0007007)2.82463673
144signal transduction involved in cell cycle checkpoint (GO:0072395)2.82337717
145L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.82043863
146* recombinational repair (GO:0000725)2.81840470
147regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.80421599
148regulation of ubiquitin-protein transferase activity (GO:0051438)2.80066047
149meiotic chromosome segregation (GO:0045132)2.79942926
150DNA ligation (GO:0006266)2.79752244
151pseudouridine synthesis (GO:0001522)2.79504896
152* double-strand break repair via homologous recombination (GO:0000724)2.79169825
153centriole replication (GO:0007099)2.78918980
154ribosome biogenesis (GO:0042254)2.78662034
155GTP biosynthetic process (GO:0006183)2.78394010
156protein targeting to mitochondrion (GO:0006626)2.75480415

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.62742990
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.43699705
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.96483395
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.65632951
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.54885128
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.44956381
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.22735473
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.13194712
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.12798997
10* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.09847742
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.03305851
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.00150582
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.96155996
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.94148940
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.90894844
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.71140293
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.66300325
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.62373986
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.48706209
20VDR_23849224_ChIP-Seq_CD4+_Human2.43163567
21ZNF274_21170338_ChIP-Seq_K562_Hela2.41845048
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.41122892
23AR_21909140_ChIP-Seq_LNCAP_Human2.38180674
24ELK1_19687146_ChIP-ChIP_HELA_Human2.36898093
25XRN2_22483619_ChIP-Seq_HELA_Human2.33445845
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32842640
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.32069750
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.28476632
29RBPJ_22232070_ChIP-Seq_NCS_Mouse2.23728481
30DCP1A_22483619_ChIP-Seq_HELA_Human2.17175175
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.15209147
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.13751272
33VDR_22108803_ChIP-Seq_LS180_Human2.10387101
34TTF2_22483619_ChIP-Seq_HELA_Human2.01730214
35THAP11_20581084_ChIP-Seq_MESCs_Mouse2.01362297
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.99120005
37FOXP3_21729870_ChIP-Seq_TREG_Human1.98765653
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93295469
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90028051
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.87201026
41GABP_19822575_ChIP-Seq_HepG2_Human1.87165120
42KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.84614049
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83745886
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77385671
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.76893041
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76261521
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.73916742
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.73723207
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72398584
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72205424
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.66687750
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.64730024
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.62735926
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60145331
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.59342464
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.59184095
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58072343
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57156872
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51975006
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51270656
61NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.51152256
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.49257997
63IGF1R_20145208_ChIP-Seq_DFB_Human1.47661115
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45116268
65TAF15_26573619_Chip-Seq_HEK293_Human1.42839143
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40753576
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.39831623
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34439800
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34130317
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34049599
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33540304
72IRF1_19129219_ChIP-ChIP_H3396_Human1.33242607
73P300_19829295_ChIP-Seq_ESCs_Human1.32584078
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.31906712
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.29016586
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.29011994
77MYC_18940864_ChIP-ChIP_HL60_Human1.24543878
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24480259
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.23227839
80TP53_22573176_ChIP-Seq_HFKS_Human1.20267695
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20003367
82EGR1_19374776_ChIP-ChIP_THP-1_Human1.19043916
83KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.18893138
84KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.18893138
85KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.18893138
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17930965
87TFEB_21752829_ChIP-Seq_HELA_Human1.17930124
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17029095
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16988678
90IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12416136
91ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11839547
92SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11144041
93SOX17_20123909_ChIP-Seq_XEN_Mouse1.11072395
94HTT_18923047_ChIP-ChIP_STHdh_Human1.10108905
95TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09696307
96KDM5A_27292631_Chip-Seq_BREAST_Human1.09683191
97SOX2_19829295_ChIP-Seq_ESCs_Human1.07829427
98NANOG_19829295_ChIP-Seq_ESCs_Human1.07829427
99FOXA1_25329375_ChIP-Seq_VCAP_Human1.07147410
100FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07147410
101GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06781165
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06541275
103POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06211166
104HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05922355
105E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05526021
106NANOG_16153702_ChIP-ChIP_HESCs_Human1.05232537
107KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03849304
108CIITA_25753668_ChIP-Seq_RAJI_Human1.03518641
109CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02373123
110CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01023724
111TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00202308
112HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98297047
113CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98268242
114CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97947038
115FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97234819
116SOX2_16153702_ChIP-ChIP_HESCs_Human0.96860248
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95437215
118AR_20517297_ChIP-Seq_VCAP_Human0.95029152
119SALL4_22934838_ChIP-ChIP_CD34+_Human0.93780769
120EZH2_27294783_Chip-Seq_NPCs_Mouse0.93747378
121BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93376242
122FUS_26573619_Chip-Seq_HEK293_Human0.92933789
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92522281
124SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92365532
125ER_23166858_ChIP-Seq_MCF-7_Human0.90876739
126CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89741927
127CBP_20019798_ChIP-Seq_JUKART_Human0.88600221
128IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88600221
129NANOG_21062744_ChIP-ChIP_HESCs_Human0.87781799
130FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87471600
131DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87194364
132GBX2_23144817_ChIP-Seq_PC3_Human0.86846269
133SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86835815
134CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85686801
135PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.85618564
136HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84636978
137SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.82942679
138EWS_26573619_Chip-Seq_HEK293_Human0.81467652
139STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81388004

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.79772990
2MP0004957_abnormal_blastocyst_morpholog3.66541634
3MP0010094_abnormal_chromosome_stability3.33055889
4MP0003123_paternal_imprinting3.08724419
5MP0003077_abnormal_cell_cycle3.01589586
6MP0008057_abnormal_DNA_replication2.82770383
7MP0008007_abnormal_cellular_replicative2.80071298
8MP0003806_abnormal_nucleotide_metabolis2.76098051
9MP0008932_abnormal_embryonic_tissue2.75946343
10MP0003111_abnormal_nucleus_morphology2.67052885
11MP0008438_abnormal_cutaneous_collagen2.47281667
12MP0008877_abnormal_DNA_methylation2.40031761
13MP0006072_abnormal_retinal_apoptosis2.39862878
14MP0003121_genomic_imprinting2.28981503
15MP0008058_abnormal_DNA_repair2.27652511
16MP0003718_maternal_effect2.23545469
17MP0003195_calcinosis2.18596242
18MP0010030_abnormal_orbit_morphology2.09726226
19MP0000372_irregular_coat_pigmentation2.08409759
20MP0005503_abnormal_tendon_morphology2.05084982
21MP0005084_abnormal_gallbladder_morpholo2.04106068
22MP0003186_abnormal_redox_activity1.93658185
23MP0008789_abnormal_olfactory_epithelium1.91867344
24MP0006036_abnormal_mitochondrial_physio1.85421901
25MP0003950_abnormal_plasma_membrane1.81648971
26MP0006035_abnormal_mitochondrial_morpho1.79674601
27MP0002837_dystrophic_cardiac_calcinosis1.78649606
28MP0000350_abnormal_cell_proliferation1.77328249
29MP0001730_embryonic_growth_arrest1.71590863
30MP0003786_premature_aging1.68026743
31MP0004147_increased_porphyrin_level1.66143428
32MP0009250_abnormal_appendicular_skeleto1.55756558
33MP0003937_abnormal_limbs/digits/tail_de1.48518385
34MP0005253_abnormal_eye_physiology1.47520106
35MP0001764_abnormal_homeostasis1.46072868
36MP0003122_maternal_imprinting1.44507031
37MP0005551_abnormal_eye_electrophysiolog1.42468870
38MP0001697_abnormal_embryo_size1.40550672
39MP0005275_abnormal_skin_tensile1.39522055
40MP0003136_yellow_coat_color1.38284455
41MP0002085_abnormal_embryonic_tissue1.36726259
42MP0003941_abnormal_skin_development1.35782391
43MP0002938_white_spotting1.34547679
44MP0008995_early_reproductive_senescence1.33205176
45MP0003315_abnormal_perineum_morphology1.32509053
46MP0002277_abnormal_respiratory_mucosa1.32117010
47MP0005410_abnormal_fertilization1.30044938
48MP0006054_spinal_hemorrhage1.26956599
49MP0002138_abnormal_hepatobiliary_system1.25408453
50MP0002210_abnormal_sex_determination1.22960931
51MP0000358_abnormal_cell_content/1.22915501
52MP0005623_abnormal_meninges_morphology1.20726724
53MP0002084_abnormal_developmental_patter1.19286269
54MP0002148_abnormal_hypersensitivity_rea1.18476316
55MP0002254_reproductive_system_inflammat1.17567661
56MP0005508_abnormal_skeleton_morphology1.17563510
57MP0001542_abnormal_bone_strength1.16443005
58MP0005389_reproductive_system_phenotype1.16104475
59MP0005394_taste/olfaction_phenotype1.15601991
60MP0005499_abnormal_olfactory_system1.15601991
61MP0003755_abnormal_palate_morphology1.15599661
62MP0008872_abnormal_physiological_respon1.14495013
63MP0004197_abnormal_fetal_growth/weight/1.14465894
64MP0010352_gastrointestinal_tract_polyps1.14170625
65MP0001672_abnormal_embryogenesis/_devel1.13190359
66MP0005380_embryogenesis_phenotype1.13190359
67MP0002282_abnormal_trachea_morphology1.12948820
68MP0003385_abnormal_body_wall1.12606571
69MP0002234_abnormal_pharynx_morphology1.12069870
70MP0003567_abnormal_fetal_cardiomyocyte1.11763266
71MP0002080_prenatal_lethality1.11121434
72MP0004142_abnormal_muscle_tone1.09238087
73MP0001293_anophthalmia1.08912829
74MP0003942_abnormal_urinary_system1.08306194
75MP0001986_abnormal_taste_sensitivity1.08237269
76MP0005645_abnormal_hypothalamus_physiol1.07374901
77MP0000569_abnormal_digit_pigmentation1.06663630
78MP0008875_abnormal_xenobiotic_pharmacok1.06361610
79MP0009379_abnormal_foot_pigmentation1.05147041
80MP0000049_abnormal_middle_ear1.05118248
81MP0005023_abnormal_wound_healing1.04067734
82MP0005075_abnormal_melanosome_morpholog1.03465907
83MP0009785_altered_susceptibility_to1.01988859
84MP0000537_abnormal_urethra_morphology1.01445772
85MP0004272_abnormal_basement_membrane1.00622284
86MP0001984_abnormal_olfaction1.00002062
87MP0002638_abnormal_pupillary_reflex0.99629158
88MP0000653_abnormal_sex_gland0.99095099
89MP0001119_abnormal_female_reproductive0.99031456
90MP0000427_abnormal_hair_cycle0.98423405
91MP0003984_embryonic_growth_retardation0.97672229
92MP0006082_CNS_inflammation0.97149024
93MP0009697_abnormal_copulation0.96962978
94MP0002932_abnormal_joint_morphology0.96208927
95MP0001145_abnormal_male_reproductive0.95860670
96MP0002111_abnormal_tail_morphology0.95553016
97MP0005646_abnormal_pituitary_gland0.95219074
98MP0002088_abnormal_embryonic_growth/wei0.95094278
99MP0005671_abnormal_response_to0.94821762
100MP0004215_abnormal_myocardial_fiber0.94565945
101MP0000516_abnormal_urinary_system0.94493020
102MP0005367_renal/urinary_system_phenotyp0.94493020
103MP0002396_abnormal_hematopoietic_system0.93794500
104MP0003011_delayed_dark_adaptation0.93420534
105MP0003698_abnormal_male_reproductive0.93142994
106MP0005395_other_phenotype0.92028460
107MP0003279_aneurysm0.91044461
108MP0002095_abnormal_skin_pigmentation0.90611113
109MP0000631_abnormal_neuroendocrine_gland0.90593508
110MP0002102_abnormal_ear_morphology0.89307884
111MP0006292_abnormal_olfactory_placode0.88913546
112MP0000383_abnormal_hair_follicle0.88755431
113MP0009053_abnormal_anal_canal0.88673449
114MP0003787_abnormal_imprinting0.88205126
115MP0001243_abnormal_dermal_layer0.86643198
116MP0005379_endocrine/exocrine_gland_phen0.86494674
117MP0000750_abnormal_muscle_regeneration0.86268323
118MP0000762_abnormal_tongue_morphology0.86024240
119MP0001929_abnormal_gametogenesis0.85942475
120MP0000428_abnormal_craniofacial_morphol0.85475444
121MP0000733_abnormal_muscle_development0.85327332
122MP0000313_abnormal_cell_death0.85203283
123MP0002114_abnormal_axial_skeleton0.85079654
124MP0005174_abnormal_tail_pigmentation0.84474417
125MP0002653_abnormal_ependyma_morphology0.84332131
126MP0002751_abnormal_autonomic_nervous0.84111308
127MP0002086_abnormal_extraembryonic_tissu0.83664905
128MP0002163_abnormal_gland_morphology0.83272803
129MP0003890_abnormal_embryonic-extraembry0.83100205
130MP0004233_abnormal_muscle_weight0.82237388
131MP0004133_heterotaxia0.81829001
132MP0002006_tumorigenesis0.81786573
133MP0005171_absent_coat_pigmentation0.80725944
134MP0004134_abnormal_chest_morphology0.80197785
135MP0002019_abnormal_tumor_incidence0.79796957
136MP0002249_abnormal_larynx_morphology0.79693815
137MP0004084_abnormal_cardiac_muscle0.79378641
138MP0010678_abnormal_skin_adnexa0.79163141
139MP0003119_abnormal_digestive_system0.76075333
140MP0002736_abnormal_nociception_after0.76034235
141MP0000432_abnormal_head_morphology0.75944350
142MP0004808_abnormal_hematopoietic_stem0.75878134
143MP0001286_abnormal_eye_development0.75565070
144MP0009333_abnormal_splenocyte_physiolog0.75068244
145MP0001485_abnormal_pinna_reflex0.73500352
146MP0009384_cardiac_valve_regurgitation0.73078804
147MP0002116_abnormal_craniofacial_bone0.72744209
148MP0000647_abnormal_sebaceous_gland0.71896891
149MP0001835_abnormal_antigen_presentation0.71718473
150MP0001324_abnormal_eye_pigmentation0.71385993
151MP0009764_decreased_sensitivity_to0.71138210
152MP0005266_abnormal_metabolism0.70832160
153MP0001919_abnormal_reproductive_system0.70574831
154MP0002160_abnormal_reproductive_system0.69573953
155MP0008873_increased_physiological_sensi0.69470825
156MP0010307_abnormal_tumor_latency0.69329007
157MP0002109_abnormal_limb_morphology0.69170390
158MP0003705_abnormal_hypodermis_morpholog0.68471431
159MP0001529_abnormal_vocalization0.67704718
160MP0002233_abnormal_nose_morphology0.67620416
161MP0002090_abnormal_vision0.67093323
162MP0005195_abnormal_posterior_eye0.65851869
163MP0002876_abnormal_thyroid_physiology0.63195489
164MP0005636_abnormal_mineral_homeostasis0.62437998
165MP0005391_vision/eye_phenotype0.61903137

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.52923430
2Breast hypoplasia (HP:0003187)3.94516416
3Acute encephalopathy (HP:0006846)3.89106997
4Lipid accumulation in hepatocytes (HP:0006561)3.66012913
5Hepatocellular necrosis (HP:0001404)3.60777694
6Methylmalonic acidemia (HP:0002912)3.44186312
7Hepatic necrosis (HP:0002605)3.42271063
8Protrusio acetabuli (HP:0003179)3.22371556
9Renal Fanconi syndrome (HP:0001994)3.17565253
10Pancreatic cysts (HP:0001737)3.15682708
11Pancreatic fibrosis (HP:0100732)3.05679530
12Molar tooth sign on MRI (HP:0002419)3.01575465
13Abnormality of midbrain morphology (HP:0002418)3.01575465
14True hermaphroditism (HP:0010459)3.00742723
15Methylmalonic aciduria (HP:0012120)2.90380985
16Premature rupture of membranes (HP:0001788)2.88868910
17Patellar aplasia (HP:0006443)2.88177437
18Cerebral hypomyelination (HP:0006808)2.88110582
19Abnormality of the labia minora (HP:0012880)2.84753664
20Cerebral edema (HP:0002181)2.80544693
21Ankle contracture (HP:0006466)2.75371336
22Aplasia/Hypoplasia of the patella (HP:0006498)2.69766606
23Selective tooth agenesis (HP:0001592)2.68401372
24Nephronophthisis (HP:0000090)2.67718637
25Increased serum lactate (HP:0002151)2.67202415
26Exertional dyspnea (HP:0002875)2.64734057
27Supernumerary spleens (HP:0009799)2.62646781
28Chromosomal breakage induced by crosslinking agents (HP:0003221)2.59474101
29Abnormality of the anterior horn cell (HP:0006802)2.57142061
30Degeneration of anterior horn cells (HP:0002398)2.57142061
31Abnormality of dentin (HP:0010299)2.54858085
32Medial flaring of the eyebrow (HP:0010747)2.50027734
33Glossoptosis (HP:0000162)2.49753367
34Colon cancer (HP:0003003)2.48836255
35Increased serum pyruvate (HP:0003542)2.48773742
36Abnormality of glycolysis (HP:0004366)2.48773742
37Lactic acidosis (HP:0003128)2.46220029
38Abnormality of chromosome stability (HP:0003220)2.45206473
39Hyperglycinemia (HP:0002154)2.41401236
40Carpal bone hypoplasia (HP:0001498)2.40454877
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.40242809
423-Methylglutaconic aciduria (HP:0003535)2.40065750
43Adrenal hypoplasia (HP:0000835)2.35609299
44Slender long bone (HP:0003100)2.34522305
45Irregular epiphyses (HP:0010582)2.34518805
46Respiratory failure (HP:0002878)2.33514126
47Medulloblastoma (HP:0002885)2.33399707
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.30769938
49Soft skin (HP:0000977)2.29850900
50Abnormality of cells of the erythroid lineage (HP:0012130)2.29511197
51Trismus (HP:0000211)2.28835309
52Abnormal umbilical cord blood vessels (HP:0011403)2.26182252
53Single umbilical artery (HP:0001195)2.26182252
54Abnormality of the fetal cardiovascular system (HP:0010948)2.26182252
55Reticulocytopenia (HP:0001896)2.25837245
56Abnormality of the umbilical cord (HP:0010881)2.25483841
57Optic disc pallor (HP:0000543)2.23932731
58Increased intramyocellular lipid droplets (HP:0012240)2.23756272
59Lethargy (HP:0001254)2.22558676
60Abnormality of the preputium (HP:0100587)2.21103832
61Atresia of the external auditory canal (HP:0000413)2.19262966
62Abnormality of aspartate family amino acid metabolism (HP:0010899)2.16652239
63Stenosis of the external auditory canal (HP:0000402)2.16290876
64Acute necrotizing encephalopathy (HP:0006965)2.15492756
65Abnormality of renal resorption (HP:0011038)2.15218670
66Abnormality of the renal medulla (HP:0100957)2.13529250
67Rough bone trabeculation (HP:0100670)2.13465547
68Congenital, generalized hypertrichosis (HP:0004540)2.12156059
69Secondary amenorrhea (HP:0000869)2.11371680
70Short tibia (HP:0005736)2.10762562
71Abnormal lung lobation (HP:0002101)2.09021001
72Aplasia/Hypoplasia of the sacrum (HP:0008517)2.08287471
73Aplasia/Hypoplasia of the sternum (HP:0006714)2.08090863
74Pancytopenia (HP:0001876)2.05550468
75Aplasia/Hypoplasia of the tongue (HP:0010295)2.04790359
76Premature ovarian failure (HP:0008209)2.03668121
77Duodenal stenosis (HP:0100867)2.03489537
78Small intestinal stenosis (HP:0012848)2.03489537
79Abnormality of methionine metabolism (HP:0010901)2.03001915
80Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.01922946
81Hypoplastic pelvis (HP:0008839)2.01311530
82Sclerocornea (HP:0000647)2.00346268
83Calcaneovalgus deformity (HP:0001848)1.99525958
84Exercise intolerance (HP:0003546)1.98693252
85CNS demyelination (HP:0007305)1.97938035
86Nephrogenic diabetes insipidus (HP:0009806)1.96767422
87Aplasia/Hypoplasia of the tibia (HP:0005772)1.96742164
88Absent radius (HP:0003974)1.95702593
89Leukodystrophy (HP:0002415)1.95634066
90Flat capital femoral epiphysis (HP:0003370)1.95260604
91Type I transferrin isoform profile (HP:0003642)1.93831538
92Sloping forehead (HP:0000340)1.93480766
93Median cleft lip (HP:0000161)1.92767222
94Deviation of the thumb (HP:0009603)1.92577390
95Aplastic anemia (HP:0001915)1.92510382
96Abnormal number of erythroid precursors (HP:0012131)1.92288159
97Breech presentation (HP:0001623)1.91308745
98Abnormality of the renal cortex (HP:0011035)1.90983166
99Premature graying of hair (HP:0002216)1.88518375
100Abnormality of the phalanges of the 2nd finger (HP:0009541)1.88497511
101Aplasia involving forearm bones (HP:0009822)1.88096236
102Absent forearm bone (HP:0003953)1.88096236
103Embryonal renal neoplasm (HP:0011794)1.87379272
104Respiratory difficulties (HP:0002880)1.87379109
105Proximal placement of thumb (HP:0009623)1.87260199
106Abnormality of vitamin B metabolism (HP:0004340)1.86757207
107Congenital primary aphakia (HP:0007707)1.86725226
108Abolished electroretinogram (ERG) (HP:0000550)1.86319176
109Renal cortical cysts (HP:0000803)1.85958995
110Clubbing of toes (HP:0100760)1.85939016
111Congenital stationary night blindness (HP:0007642)1.85694909
112Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.85125815
113Decreased activity of mitochondrial respiratory chain (HP:0008972)1.85125815
114Abnormality of the vitamin B12 metabolism (HP:0004341)1.84619715
115Abnormality of the duodenum (HP:0002246)1.84349860
116Vertebral compression fractures (HP:0002953)1.84031805
117Oral leukoplakia (HP:0002745)1.83688202
118Glycosuria (HP:0003076)1.83557468
119Abnormality of urine glucose concentration (HP:0011016)1.83557468
120Nephroblastoma (Wilms tumor) (HP:0002667)1.83086302
121Decreased electroretinogram (ERG) amplitude (HP:0000654)1.82856064
122Rhabdomyosarcoma (HP:0002859)1.82456707
123Volvulus (HP:0002580)1.82371052
124Hypothermia (HP:0002045)1.81190849
125Deformed tarsal bones (HP:0008119)1.80356563
126Stomatitis (HP:0010280)1.79326997
127Mitochondrial inheritance (HP:0001427)1.79143588
128Abnormal mitochondria in muscle tissue (HP:0008316)1.78724886
129Abnormality of the pons (HP:0007361)1.78672152
130Hypoplasia of the capital femoral epiphysis (HP:0003090)1.76773592
131Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.76482154
132Abnormal protein N-linked glycosylation (HP:0012347)1.76482154
133Abnormal protein glycosylation (HP:0012346)1.76482154
134Abnormal glycosylation (HP:0012345)1.76482154
135Abnormality of the calcaneus (HP:0008364)1.76137008
136CNS hypomyelination (HP:0003429)1.75463409
137Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.74776515
138Macrocytic anemia (HP:0001972)1.74336627
139Type II lissencephaly (HP:0007260)1.74219446
140Postnatal microcephaly (HP:0005484)1.73302024
141Dicarboxylic aciduria (HP:0003215)1.73086611
142Abnormality of dicarboxylic acid metabolism (HP:0010995)1.73086611
143Abnormality of serum amino acid levels (HP:0003112)1.72750979
144Triphalangeal thumb (HP:0001199)1.72618874
145Meckel diverticulum (HP:0002245)1.72377412
146Biconcave vertebral bodies (HP:0004586)1.71342890
147Increased CSF lactate (HP:0002490)1.70740684
148Increased hepatocellular lipid droplets (HP:0006565)1.70731917
149Muscle fiber atrophy (HP:0100295)1.70180490
150Neoplasm of the pancreas (HP:0002894)1.68999580
151Type 2 muscle fiber atrophy (HP:0003554)1.68693557
152Diastasis recti (HP:0001540)1.68374791
153Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.68158010
154Absent epiphyses (HP:0010577)1.68158010
155Microretrognathia (HP:0000308)1.66726100
156Shallow orbits (HP:0000586)1.64818378
157Wormian bones (HP:0002645)1.64721980
158Abdominal situs inversus (HP:0003363)1.64298850
159Abnormality of abdominal situs (HP:0011620)1.64298850
160Mild short stature (HP:0003502)1.62359643
161Abnormality of the ileum (HP:0001549)1.61949114
162Agnosia (HP:0010524)1.60995043
163Asplenia (HP:0001746)1.60972718
164Delayed cranial suture closure (HP:0000270)1.59820423
165Abnormal number of incisors (HP:0011064)1.59281925
166Chromsome breakage (HP:0040012)1.59228709
167Abnormal trabecular bone morphology (HP:0100671)1.58287148
168Abnormality of alanine metabolism (HP:0010916)1.57782072
169Hyperalaninemia (HP:0003348)1.57782072
170Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.57782072
171Fused cervical vertebrae (HP:0002949)1.57731183
172Progressive macrocephaly (HP:0004481)1.56644047
173Microglossia (HP:0000171)1.56103596
174Wrist flexion contracture (HP:0001239)1.56019651
175Abnormalities of placenta or umbilical cord (HP:0001194)1.55650381
176Sparse lateral eyebrow (HP:0005338)1.55412368
177Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.54431943

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.34206491
2VRK23.76764022
3CDC73.51801226
4EIF2AK13.43529266
5WEE13.36575840
6ACVR1B2.72197631
7NUAK12.61998745
8TESK22.47495496
9NME22.41892413
10FRK2.38828006
11MAP4K22.34053449
12TSSK62.31754552
13TRIM282.22638056
14PLK42.21624635
15MKNK12.17985955
16TAOK32.15830050
17PBK2.08530519
18BRSK22.08081311
19LIMK12.04869876
20SRPK11.99481770
21STK161.99022352
22TAF11.97743613
23VRK11.95281295
24TTK1.94270971
25EIF2AK31.84955789
26PLK11.79838020
27PLK31.79586613
28MOS1.73476297
29BCKDK1.55239649
30CDK81.50103500
31WNK31.48317150
32TGFBR11.47821088
33AURKB1.41331906
34PASK1.41080065
35ADRBK21.37533714
36PIM21.36879672
37TESK11.36287800
38RPS6KB21.36282563
39AURKA1.34023846
40BCR1.30794012
41TNIK1.30514517
42STK38L1.29943395
43STK391.27838903
44MAP3K121.27599355
45TLK11.24899899
46BMPR1B1.23467760
47NEK11.23216276
48RPS6KA41.21800863
49BRAF1.17564308
50LATS21.17023440
51ARAF1.16746946
52CDK71.14721997
53MKNK21.12313479
54STK101.12288147
55CHEK21.12130878
56NEK21.11161502
57GRK11.10641613
58BRSK11.07636605
59DYRK21.07084671
60PLK20.98552281
61MST40.96767884
62ZAK0.96479894
63PAK40.95712030
64MAPKAPK50.95331369
65TXK0.93034330
66WNK40.92862075
67DYRK30.92327930
68EPHA20.92056949
69MAP3K80.91547302
70ATR0.89354981
71OXSR10.88498358
72CHEK10.82674133
73NME10.81520556
74CSNK1G20.81437554
75RPS6KA50.80663337
76PAK10.79266136
77MELK0.78348039
78DAPK10.76774583
79STK30.75622222
80MAP3K40.74967363
81ILK0.73275504
82PNCK0.67446015
83EIF2AK20.65683411
84MET0.65295701
85CSNK1G30.65263589
86CCNB10.65136813
87STK40.63294954
88MAPKAPK30.62768435
89MAPK130.62113202
90CSNK2A10.61904573
91IKBKB0.61531680
92ATM0.61498954
93NEK90.61337166
94FLT30.61231249
95PRKCI0.60599179
96INSRR0.60494727
97SCYL20.58855220
98BMPR20.58568822
99CSNK2A20.58109116
100MUSK0.57920906
101ERBB40.57619138
102DDR20.57487092
103CDK140.56023316
104TEC0.54354888
105STK240.53714841
106PINK10.52769687
107CDK20.51072592
108ERBB30.49298873
109CDK10.48606059
110LRRK20.48576819
111PAK20.47725457
112CSNK1G10.45416031
113TRPM70.45244774
114KDR0.44572062
115ROCK20.43647849
116PIM10.43250783
117CDK180.42654405
118CASK0.41654192
119PRKCE0.41344162
120RAF10.41299420
121CDK190.41187267
122TIE10.40920147
123PIK3CG0.40101753
124CDK150.40070913
125CDK11A0.39437836
126PRKCG0.38801795
127ABL20.38422539
128PDK20.37384086
129CSNK1A1L0.36873742
130MAP2K70.36229170
131LATS10.33502768
132MAP3K60.32140720
133PRKCQ0.27813082
134ADRBK10.27162732
135GRK70.25052640
136CDK90.22069550
137PKN10.18189564

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.94768850
2DNA replication_Homo sapiens_hsa030303.77700296
3Ribosome_Homo sapiens_hsa030103.53855420
4Mismatch repair_Homo sapiens_hsa034303.47206581
5RNA polymerase_Homo sapiens_hsa030203.43194033
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.25544504
7Spliceosome_Homo sapiens_hsa030403.00215630
8RNA transport_Homo sapiens_hsa030132.85614124
9Nucleotide excision repair_Homo sapiens_hsa034202.79566745
10Cell cycle_Homo sapiens_hsa041102.75895455
11Homologous recombination_Homo sapiens_hsa034402.63374521
12Basal transcription factors_Homo sapiens_hsa030222.46821945
13Base excision repair_Homo sapiens_hsa034102.39071495
14Protein export_Homo sapiens_hsa030602.14767671
15Non-homologous end-joining_Homo sapiens_hsa034502.14495579
16RNA degradation_Homo sapiens_hsa030182.06061306
17Pyrimidine metabolism_Homo sapiens_hsa002402.05279570
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.82875302
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73191518
20Propanoate metabolism_Homo sapiens_hsa006401.69305215
21Fanconi anemia pathway_Homo sapiens_hsa034601.65383283
22mRNA surveillance pathway_Homo sapiens_hsa030151.63156575
23Fatty acid elongation_Homo sapiens_hsa000621.53095147
24Parkinsons disease_Homo sapiens_hsa050121.50748741
25Oxidative phosphorylation_Homo sapiens_hsa001901.50740271
26p53 signaling pathway_Homo sapiens_hsa041151.48518188
27Huntingtons disease_Homo sapiens_hsa050161.36956902
28One carbon pool by folate_Homo sapiens_hsa006701.29933897
29Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.28019717
30Purine metabolism_Homo sapiens_hsa002301.25033610
31Oocyte meiosis_Homo sapiens_hsa041141.21678804
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21112450
33Epstein-Barr virus infection_Homo sapiens_hsa051691.20339535
34Phototransduction_Homo sapiens_hsa047441.14364882
35Sulfur metabolism_Homo sapiens_hsa009201.11638666
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07848311
37TGF-beta signaling pathway_Homo sapiens_hsa043501.07395343
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06739323
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03415397
40Butanoate metabolism_Homo sapiens_hsa006501.01111845
41Peroxisome_Homo sapiens_hsa041461.00650605
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99389513
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96153381
44Selenocompound metabolism_Homo sapiens_hsa004500.92718459
45Asthma_Homo sapiens_hsa053100.92072260
46Systemic lupus erythematosus_Homo sapiens_hsa053220.91306205
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86019491
48Hippo signaling pathway_Homo sapiens_hsa043900.85577008
49Regulation of autophagy_Homo sapiens_hsa041400.83849485
50Viral carcinogenesis_Homo sapiens_hsa052030.83250271
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82837223
52Alzheimers disease_Homo sapiens_hsa050100.81482314
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81041989
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79496707
55Vitamin B6 metabolism_Homo sapiens_hsa007500.74949155
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.73603618
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72621910
58Type I diabetes mellitus_Homo sapiens_hsa049400.72414004
59Metabolic pathways_Homo sapiens_hsa011000.72382445
60HTLV-I infection_Homo sapiens_hsa051660.71978024
61Tryptophan metabolism_Homo sapiens_hsa003800.70641228
62ECM-receptor interaction_Homo sapiens_hsa045120.70555780
63MicroRNAs in cancer_Homo sapiens_hsa052060.68310296
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.68232495
65Antigen processing and presentation_Homo sapiens_hsa046120.67092044
66Nitrogen metabolism_Homo sapiens_hsa009100.66555841
67Pyruvate metabolism_Homo sapiens_hsa006200.65862745
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65304476
69Hedgehog signaling pathway_Homo sapiens_hsa043400.65242706
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63784910
71Collecting duct acid secretion_Homo sapiens_hsa049660.63642201
72Shigellosis_Homo sapiens_hsa051310.62338727
73Basal cell carcinoma_Homo sapiens_hsa052170.60936195
74Caffeine metabolism_Homo sapiens_hsa002320.59818405
75Primary immunodeficiency_Homo sapiens_hsa053400.58423266
76Alcoholism_Homo sapiens_hsa050340.58149012
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58006735
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57651984
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57156623
80Herpes simplex infection_Homo sapiens_hsa051680.56704452
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55503522
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53512308
83Colorectal cancer_Homo sapiens_hsa052100.53495845
84Legionellosis_Homo sapiens_hsa051340.50913799
85Ether lipid metabolism_Homo sapiens_hsa005650.50152436
86Tight junction_Homo sapiens_hsa045300.50110701
87Thyroid cancer_Homo sapiens_hsa052160.49470702
88Autoimmune thyroid disease_Homo sapiens_hsa053200.48344661
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47111210
90Malaria_Homo sapiens_hsa051440.46741653
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.46667856
92PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46521688
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46479937
94Melanoma_Homo sapiens_hsa052180.46126911
95Arachidonic acid metabolism_Homo sapiens_hsa005900.45380915
96Small cell lung cancer_Homo sapiens_hsa052220.45172598
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43053772
98Pathways in cancer_Homo sapiens_hsa052000.42975785
99Olfactory transduction_Homo sapiens_hsa047400.42392372
100Focal adhesion_Homo sapiens_hsa045100.40857102
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40176995
102Vibrio cholerae infection_Homo sapiens_hsa051100.39272136
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39261185
104Adherens junction_Homo sapiens_hsa045200.38821177
105Steroid biosynthesis_Homo sapiens_hsa001000.37646532
106Wnt signaling pathway_Homo sapiens_hsa043100.37275946
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36341252
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36222049
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35871045
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34359811
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.33885606
112Proteoglycans in cancer_Homo sapiens_hsa052050.33540836
113Bladder cancer_Homo sapiens_hsa052190.33057983
114Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.32682332
115Folate biosynthesis_Homo sapiens_hsa007900.32419465
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32166979
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31689944
118Viral myocarditis_Homo sapiens_hsa054160.31629532
119Chemical carcinogenesis_Homo sapiens_hsa052040.31474744
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.31238639
121Cardiac muscle contraction_Homo sapiens_hsa042600.30268164
122Sulfur relay system_Homo sapiens_hsa041220.29956290
123Prostate cancer_Homo sapiens_hsa052150.28549318
124Glutathione metabolism_Homo sapiens_hsa004800.28101896
125Phagosome_Homo sapiens_hsa041450.27040191
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26728644
127HIF-1 signaling pathway_Homo sapiens_hsa040660.26469940
128Pancreatic cancer_Homo sapiens_hsa052120.26428700
129Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26067077
130Linoleic acid metabolism_Homo sapiens_hsa005910.25581387
131Fatty acid metabolism_Homo sapiens_hsa012120.25223275
132Hepatitis B_Homo sapiens_hsa051610.24880738
133Retinol metabolism_Homo sapiens_hsa008300.23111875
134Renal cell carcinoma_Homo sapiens_hsa052110.23065209
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.21198280
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21125555
137beta-Alanine metabolism_Homo sapiens_hsa004100.20988517
138Apoptosis_Homo sapiens_hsa042100.20746506
139Notch signaling pathway_Homo sapiens_hsa043300.20595010
140Rheumatoid arthritis_Homo sapiens_hsa053230.20552327
141Allograft rejection_Homo sapiens_hsa053300.19619673
142Cysteine and methionine metabolism_Homo sapiens_hsa002700.19380315
143Leukocyte transendothelial migration_Homo sapiens_hsa046700.18645543
144N-Glycan biosynthesis_Homo sapiens_hsa005100.18081013
145Measles_Homo sapiens_hsa051620.13846665
146Biosynthesis of amino acids_Homo sapiens_hsa012300.13564219
147Ovarian steroidogenesis_Homo sapiens_hsa049130.13560450
148Graft-versus-host disease_Homo sapiens_hsa053320.12303529

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