SFRP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1androgen biosynthetic process (GO:0006702)9.36087344
2cellular response to follicle-stimulating hormone stimulus (GO:0071372)9.11766677
3mesenchymal-epithelial cell signaling (GO:0060638)8.23034236
4estrogen metabolic process (GO:0008210)7.95585257
5response to follicle-stimulating hormone (GO:0032354)7.89067771
6negative regulation of biomineral tissue development (GO:0070168)7.14368655
7progesterone metabolic process (GO:0042448)6.98957917
8biomineral tissue development (GO:0031214)6.68541597
9C21-steroid hormone biosynthetic process (GO:0006700)6.65744969
10keratan sulfate biosynthetic process (GO:0018146)6.64527647
11regulation of branching involved in salivary gland morphogenesis (GO:0060693)6.54604934
12cartilage condensation (GO:0001502)6.25451091
13cell aggregation (GO:0098743)6.25451091
14peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)6.13028695
15cellular response to gonadotropin stimulus (GO:0071371)6.11199007
16mating behavior (GO:0007617)5.98427662
17replacement ossification (GO:0036075)5.98056840
18endochondral ossification (GO:0001958)5.98056840
19cellular response to antibiotic (GO:0071236)5.92152259
20keratan sulfate metabolic process (GO:0042339)5.85036667
21epoxygenase P450 pathway (GO:0019373)5.81638015
22cellular response to interferon-alpha (GO:0035457)5.76622414
23protein heterotrimerization (GO:0070208)5.64540729
24collagen fibril organization (GO:0030199)5.23882997
25uterus development (GO:0060065)5.22513461
26androgen metabolic process (GO:0008209)5.12742591
27glucocorticoid biosynthetic process (GO:0006704)5.01727282
28response to gonadotropin (GO:0034698)4.97370628
29ossification (GO:0001503)4.96076243
30sulfur compound catabolic process (GO:0044273)4.95391576
31negative regulation of bone mineralization (GO:0030502)4.90889789
32amino sugar catabolic process (GO:0046348)4.84838062
33negative regulation of complement activation (GO:0045916)4.80013588
34cellular response to growth hormone stimulus (GO:0071378)4.65994620
35positive regulation of respiratory burst (GO:0060267)4.59557278
36negative regulation of BMP signaling pathway (GO:0030514)4.56318268
37regulation of gonadotropin secretion (GO:0032276)4.48175064
38glucocorticoid metabolic process (GO:0008211)4.47214982
39response to phenylpropanoid (GO:0080184)4.36684306
40bone mineralization (GO:0030282)4.35286740
41adhesion of symbiont to host (GO:0044406)4.34662613
42vitamin D metabolic process (GO:0042359)4.25300759
43peptidyl-proline hydroxylation (GO:0019511)4.21989289
44response to insecticide (GO:0017085)4.20374649
45hormone biosynthetic process (GO:0042446)4.17919299
46glycosaminoglycan catabolic process (GO:0006027)4.16051628
47bone resorption (GO:0045453)4.15324623
48C21-steroid hormone metabolic process (GO:0008207)4.08820288
49Leydig cell differentiation (GO:0033327)4.03981725
50detection of molecule of bacterial origin (GO:0032490)4.03142197
51cellular response to toxic substance (GO:0097237)4.02095250
52keratan sulfate catabolic process (GO:0042340)4.00022084
53seminiferous tubule development (GO:0072520)3.99651088
54response to vitamin E (GO:0033197)3.94792561
55cartilage development (GO:0051216)3.90565422
56parturition (GO:0007567)3.90423536
57negative regulation of protein activation cascade (GO:2000258)3.88807798
58dermatan sulfate biosynthetic process (GO:0030208)3.85587256
59chondrocyte proliferation (GO:0035988)3.84246337
60positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.82514917
61opsonization (GO:0008228)3.81156178
62basement membrane organization (GO:0071711)3.80753499
63sequestering of extracellular ligand from receptor (GO:0035581)3.80173930
64cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.79408088
65regulation of biomineral tissue development (GO:0070167)3.73752039
66bone trabecula formation (GO:0060346)3.69314795
67protein localization to cell surface (GO:0034394)3.64672503
68positive regulation of osteoblast proliferation (GO:0033690)3.58909758
69dermatan sulfate metabolic process (GO:0030205)3.56740350
70metanephric mesenchyme development (GO:0072075)3.54253369
71collagen metabolic process (GO:0032963)3.54126895
72collagen catabolic process (GO:0030574)3.53312342
73positive regulation of hair cycle (GO:0042635)3.52431788
74positive regulation of hair follicle development (GO:0051798)3.52431788
75response to leptin (GO:0044321)3.50312754
76negative regulation of chondrocyte differentiation (GO:0032331)3.44221792
77negative regulation of ossification (GO:0030279)3.39957511
78skin morphogenesis (GO:0043589)3.39814958
79skeletal system development (GO:0001501)3.38136129
80glomerular filtration (GO:0003094)3.37734903
81regulation of steroid hormone biosynthetic process (GO:0090030)3.37383518
82platelet-derived growth factor receptor signaling pathway (GO:0048008)3.36724507
83extracellular matrix organization (GO:0030198)3.35251774
84extracellular structure organization (GO:0043062)3.34090286
85extracellular matrix assembly (GO:0085029)3.34088709
86multicellular organismal macromolecule metabolic process (GO:0044259)3.33591143
87organ induction (GO:0001759)3.29330790
88regulation of extracellular matrix disassembly (GO:0010715)3.27825818
89regulation of bone mineralization (GO:0030500)3.26024366
90cardiac muscle cell proliferation (GO:0060038)3.25322639
91multicellular organismal catabolic process (GO:0044243)3.24952771
92protein hydroxylation (GO:0018126)3.24935225
93pathway-restricted SMAD protein phosphorylation (GO:0060389)3.24626349
94regulation of complement activation (GO:0030449)3.23848864
95virion attachment to host cell (GO:0019062)3.19942887
96adhesion of symbiont to host cell (GO:0044650)3.19942887
97import into cell (GO:0098657)3.18724155
98multicellular organismal metabolic process (GO:0044236)3.16489047
99branching involved in salivary gland morphogenesis (GO:0060445)3.16052331
100negative regulation of heart growth (GO:0061117)3.15246129
101negative regulation of cardiac muscle tissue growth (GO:0055022)3.15246129
102fibril organization (GO:0097435)3.11117434
103kidney mesenchyme development (GO:0072074)3.09227610
104renal filtration (GO:0097205)3.08419834
105chondroitin sulfate catabolic process (GO:0030207)3.07917860
106regulation of chondrocyte differentiation (GO:0032330)3.07819173
107embryonic cranial skeleton morphogenesis (GO:0048701)3.07171105
108negative regulation of humoral immune response (GO:0002921)3.03862473
109response to corticosterone (GO:0051412)3.02796528
110tooth mineralization (GO:0034505)3.02694121
111regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.02591353
112face morphogenesis (GO:0060325)3.01618734
113extracellular matrix disassembly (GO:0022617)3.01571344
114positive regulation of odontogenesis (GO:0042482)2.99713806
115endodermal cell differentiation (GO:0035987)2.99459623
116chondrocyte development (GO:0002063)2.98859055
117interkinetic nuclear migration (GO:0022027)2.98715012
118glycosaminoglycan biosynthetic process (GO:0006024)2.96725412
119aminoglycan biosynthetic process (GO:0006023)2.92307840
120negative regulation of cartilage development (GO:0061037)2.91321732
121apoptotic cell clearance (GO:0043277)2.91221689
122regulation of inositol phosphate biosynthetic process (GO:0010919)2.90890484
123regulation of BMP signaling pathway (GO:0030510)2.90871530
124regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.90390095
125regulation of protein activation cascade (GO:2000257)2.88343449
126negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:2.88279585
127toxin metabolic process (GO:0009404)2.87850742
128positive regulation of macrophage activation (GO:0043032)2.87226452
129regulation of organ formation (GO:0003156)2.86601964
130regulation of hair follicle development (GO:0051797)2.85653382
131glomerular basement membrane development (GO:0032836)2.85388411
132lung secretory cell differentiation (GO:0061140)2.84306952
133regulation of macrophage cytokine production (GO:0010935)2.83304397
134bone development (GO:0060348)2.82447238
135endothelial cell proliferation (GO:0001935)2.82021321
136regulation of odontogenesis (GO:0042481)2.80621151
137cytokine metabolic process (GO:0042107)2.79936862
138phagocytosis, recognition (GO:0006910)2.78630762
139ketone biosynthetic process (GO:0042181)2.78479843
140regulation of apoptotic cell clearance (GO:2000425)2.77891278
141regulation of cardiac muscle hypertrophy (GO:0010611)2.77393452
142male genitalia development (GO:0030539)2.75482348
143regulation of bone remodeling (GO:0046850)2.74606459
144regulation of cardiac muscle cell differentiation (GO:2000725)2.70514886
145regulation of transforming growth factor beta2 production (GO:0032909)2.69920834
146regulation of muscle hypertrophy (GO:0014743)2.69882135
147negative regulation of reproductive process (GO:2000242)2.69436825
148thrombin receptor signaling pathway (GO:0070493)2.68579496
149calcium-mediated signaling using intracellular calcium source (GO:0035584)2.67723304
150regulation of hormone biosynthetic process (GO:0046885)2.66558572
151glial cell migration (GO:0008347)2.65757102
152striated muscle cell proliferation (GO:0014855)2.63372781
153endothelial cell morphogenesis (GO:0001886)2.60958146
154positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.60394397
155regulation of cartilage development (GO:0061035)2.60100473
156phospholipid homeostasis (GO:0055091)2.60029989
157mesenchymal cell proliferation (GO:0010463)2.58279288
158positive regulation of Rho protein signal transduction (GO:0035025)2.57432984
159response to interferon-alpha (GO:0035455)2.57032100
160regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.56679323
161regulation of ossification (GO:0030278)2.55615617
162blood vessel remodeling (GO:0001974)2.55503038
163hemidesmosome assembly (GO:0031581)2.55329255
164osteoblast development (GO:0002076)2.54246755
165extracellular fibril organization (GO:0043206)2.52331623
166aminoglycan catabolic process (GO:0006026)2.52304400
167radial glial cell differentiation (GO:0060019)2.52151351
168positive regulation of muscle hypertrophy (GO:0014742)2.52026192
169response to cadmium ion (GO:0046686)2.51782646
170ovarian follicle development (GO:0001541)2.51077195
171estrogen biosynthetic process (GO:0006703)16.0571455
172glucosamine-containing compound catabolic process (GO:1901072)10.8322297
173cellular response to cadmium ion (GO:0071276)10.5043269
174response to parathyroid hormone (GO:0071107)10.2117467

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_15608294_ChIP-ChIP_MCF-7_Human5.23829001
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.04889099
3CLOCK_20551151_ChIP-Seq_293T_Human4.09134165
4ESR1_22446102_ChIP-Seq_UTERUS_Mouse3.57062266
5ESR1_21235772_ChIP-Seq_MCF-7_Human3.26771554
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.12252422
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.96424877
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.71451464
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.52144167
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.37551981
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.33217360
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.23693363
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.21192498
14CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.16804641
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.11683404
16TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.08468913
17CJUN_26792858_Chip-Seq_BT549_Human2.02745407
18BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.89994344
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88303888
20HIF1A_21447827_ChIP-Seq_MCF-7_Human1.85745653
21WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.84576351
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.83558015
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.83488222
24RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.83168274
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81438196
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.80205679
27EP300_21415370_ChIP-Seq_HL-1_Mouse1.80136683
28CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.80084100
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.78113123
30NRF2_20460467_ChIP-Seq_MEFs_Mouse1.75367236
31NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.75367236
32GBX2_23144817_ChIP-Seq_PC3_Human1.74918938
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.73636255
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.73636255
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.71358958
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69470671
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.68978006
38EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.63712586
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60486587
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.59006004
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53179345
42PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51020562
43NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.50786282
44WT1_19549856_ChIP-ChIP_CCG9911_Human1.49670284
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.48274337
46TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.48034531
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47900204
48TP53_16413492_ChIP-PET_HCT116_Human1.46927132
49SALL4_18804426_ChIP-ChIP_XEN_Mouse1.46297516
50SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.46138756
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.44417615
52SOX2_20726797_ChIP-Seq_SW620_Human1.43723257
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.43284554
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.42467818
55CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.38627929
56ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.34943577
57TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.34436777
58SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33444895
59SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.33244044
60CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.32021434
61SMAD4_21799915_ChIP-Seq_A2780_Human1.31813330
62P300_19829295_ChIP-Seq_ESCs_Human1.30809113
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30187295
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.29986445
65EZH2_27304074_Chip-Seq_ESCs_Mouse1.29426488
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28650718
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27923451
68BRD4_25478319_ChIP-Seq_HGPS_Human1.27220305
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.25090112
70SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.24434425
71UBF1/2_26484160_Chip-Seq_HMECs_Human1.23540677
72JARID2_20075857_ChIP-Seq_MESCs_Mouse1.23508947
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22207832
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21963880
75WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21571858
76* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.21392535
77TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.21185763
78SOX9_24532713_ChIP-Seq_HFSC_Mouse1.20359403
79HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20028553
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18299058
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16795227
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16771851
83RNF2_27304074_Chip-Seq_ESCs_Mouse1.15861470
84EED_16625203_ChIP-ChIP_MESCs_Mouse1.15612942
85VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15558049
86SALL1_21062744_ChIP-ChIP_HESCs_Human1.15162849
87SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.14180406
88SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.14180406
89JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13831498
90GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13231547
91ELK3_25401928_ChIP-Seq_HUVEC_Human1.11970249
92SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11593978
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.11568130
94ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11420292
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11246233
96MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08700481
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08684536
98TBX20_22328084_ChIP-Seq_HEART_Mouse1.08397981
99TBX20_22080862_ChIP-Seq_HEART_Mouse1.08397981
100SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07829081
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05924206
102BCAT_22108803_ChIP-Seq_LS180_Human1.04517612
103EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04447253
104KDM2B_26808549_Chip-Seq_REH_Human1.03299071
105GATA1_22025678_ChIP-Seq_K562_Human1.02963815
106PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02763548
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02106315
108TAL1_26923725_Chip-Seq_HPCs_Mouse1.01891600
109TP53_18474530_ChIP-ChIP_U2OS_Human1.01861203
110NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01032956
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00960908
112ISL1_27105846_Chip-Seq_CPCs_Mouse1.00196922
113ARNT_22903824_ChIP-Seq_MCF-7_Human0.98972155
114SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.98935534
115NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98071458
116CDX2_22108803_ChIP-Seq_LS180_Human0.97899767
117SA1_22415368_ChIP-Seq_MEFs_Mouse0.97823446
118TP63_23658742_ChIP-Seq_EP156T_Human0.97804165
119ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97153297
120TCF4_18268006_ChIP-ChIP_LS174T_Human0.96044711
121TP53_20018659_ChIP-ChIP_R1E_Mouse0.94634591
122KDM2B_26808549_Chip-Seq_K562_Human0.94506602
123SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94060812
124FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94014946
125STAT3_23295773_ChIP-Seq_U87_Human0.93664290
126ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93174514
127P53_22387025_ChIP-Seq_ESCs_Mouse0.93046200
128SMAD3_21741376_ChIP-Seq_EPCs_Human0.92256956
129VDR_22108803_ChIP-Seq_LS180_Human0.92171060
130JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91468020
131PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91395754
132GATA3_24758297_ChIP-Seq_MCF-7_Human0.89542998
133TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88892577
134AHR_22903824_ChIP-Seq_MCF-7_Human0.88408969
135PIAS1_25552417_ChIP-Seq_VCAP_Human0.87776603
136KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87250507
137FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.87224323
138LXR_22158963_ChIP-Seq_LIVER_Mouse0.86971205
139UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86895129
140* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.86834740
141PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86606038
142DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86034223
143CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85239877
144ZFP281_27345836_Chip-Seq_ESCs_Mouse0.83245983
145PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82704807
146SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.81502138
147SMAD3_21741376_ChIP-Seq_HESCs_Human0.79988601
148KDM2B_26808549_Chip-Seq_JURKAT_Human0.79803304
149RACK7_27058665_Chip-Seq_MCF-7_Human0.79402186

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.92014639
2MP0005275_abnormal_skin_tensile4.90148431
3MP0005503_abnormal_tendon_morphology4.50666452
4MP0006054_spinal_hemorrhage3.93809364
5MP0003279_aneurysm3.00776560
6MP0002254_reproductive_system_inflammat2.95703395
7MP0005647_abnormal_sex_gland2.87894255
8MP0004272_abnormal_basement_membrane2.79807147
9MP0001958_emphysema2.71068880
10MP0001919_abnormal_reproductive_system2.60984099
11MP0002909_abnormal_adrenal_gland2.45694619
12MP0003315_abnormal_perineum_morphology2.31020023
13MP0005187_abnormal_penis_morphology2.23740450
14MP0009384_cardiac_valve_regurgitation2.19712916
15MP0010368_abnormal_lymphatic_system2.15072533
16MP0000639_abnormal_adrenal_gland2.10131740
17MP0004883_abnormal_blood_vessel1.95779374
18MP0005389_reproductive_system_phenotype1.94612164
19MP0001661_extended_life_span1.92868231
20MP0001542_abnormal_bone_strength1.91832497
21MP0000751_myopathy1.91006038
22MP0003705_abnormal_hypodermis_morpholog1.89402651
23MP0002896_abnormal_bone_mineralization1.78936804
24MP0005508_abnormal_skeleton_morphology1.76968865
25MP0003566_abnormal_cell_adhesion1.75094856
26MP0003195_calcinosis1.71802342
27MP0005164_abnormal_response_to1.62538195
28MP0005257_abnormal_intraocular_pressure1.60461023
29MP0009250_abnormal_appendicular_skeleto1.59367720
30MP0002060_abnormal_skin_morphology1.58069527
31MP0005623_abnormal_meninges_morphology1.56580154
32MP0005023_abnormal_wound_healing1.51989152
33MP0002108_abnormal_muscle_morphology1.47162087
34MP0010386_abnormal_urinary_bladder1.45015041
35MP0005083_abnormal_biliary_tract1.43103570
36MP0000013_abnormal_adipose_tissue1.41713846
37MP0002295_abnormal_pulmonary_circulatio1.33355515
38MP0000750_abnormal_muscle_regeneration1.32432027
39MP0002282_abnormal_trachea_morphology1.31715285
40MP0000767_abnormal_smooth_muscle1.30879023
41MP0002998_abnormal_bone_remodeling1.30445414
42MP0002115_abnormal_skeleton_extremities1.27178807
43MP0001879_abnormal_lymphatic_vessel1.23341452
44MP0002168_other_aberrant_phenotype1.16236241
45MP0003385_abnormal_body_wall1.11982385
46MP0004019_abnormal_vitamin_homeostasis1.11503067
47MP0000163_abnormal_cartilage_morphology1.09898344
48MP0004036_abnormal_muscle_relaxation1.09563219
49MP0005171_absent_coat_pigmentation1.08477578
50MP0000538_abnormal_urinary_bladder1.08102206
51MP0000681_abnormal_thyroid_gland1.05216478
52MP0000343_altered_response_to1.04762385
53MP0000604_amyloidosis1.03847060
54MP0001881_abnormal_mammary_gland1.03018233
55MP0003091_abnormal_cell_migration1.01734926
56MP0002233_abnormal_nose_morphology1.01107710
57MP0002116_abnormal_craniofacial_bone1.00152312
58MP0009278_abnormal_bone_marrow0.99402544
59MP0004084_abnormal_cardiac_muscle0.97035684
60MP0000733_abnormal_muscle_development0.93666594
61MP0003935_abnormal_craniofacial_develop0.93567639
62MP0002113_abnormal_skeleton_development0.91640524
63MP0005390_skeleton_phenotype0.91021094
64MP0002114_abnormal_axial_skeleton0.90461242
65MP0004134_abnormal_chest_morphology0.89383985
66MP0002269_muscular_atrophy0.89368907
67MP0002102_abnormal_ear_morphology0.89143344
68MP0002932_abnormal_joint_morphology0.87143722
69MP0004185_abnormal_adipocyte_glucose0.86441479
70MP0003795_abnormal_bone_structure0.85748618
71MP0003567_abnormal_fetal_cardiomyocyte0.85610719
72MP0003448_altered_tumor_morphology0.85409053
73MP0001299_abnormal_eye_distance/0.84837126
74MP0006072_abnormal_retinal_apoptosis0.84655144
75MP0000462_abnormal_digestive_system0.79997482
76MP0003115_abnormal_respiratory_system0.79661659
77MP0001243_abnormal_dermal_layer0.79162955
78MP0001915_intracranial_hemorrhage0.78551936
79MP0005076_abnormal_cell_differentiation0.77326415
80MP0000762_abnormal_tongue_morphology0.76258135
81MP0000249_abnormal_blood_vessel0.74276237
82MP0001533_abnormal_skeleton_physiology0.73397081
83MP0002128_abnormal_blood_circulation0.73176811
84MP0000432_abnormal_head_morphology0.72717793
85MP0005084_abnormal_gallbladder_morpholo0.72456058
86MP0004858_abnormal_nervous_system0.71945344
87MP0002009_preneoplasia0.71629044
88MP0001765_abnormal_ion_homeostasis0.70666183
89MP0004484_altered_response_of0.70368665
90MP0001849_ear_inflammation0.70178073
91MP0005369_muscle_phenotype0.69631784
92MP0005248_abnormal_Harderian_gland0.69560732
93MP0005395_other_phenotype0.69384305
94MP0003045_fibrosis0.69256296
95MP0002089_abnormal_postnatal_growth/wei0.68402226
96MP0000428_abnormal_craniofacial_morphol0.68022125
97MP0000627_abnormal_mammary_gland0.67931389
98MP0000613_abnormal_salivary_gland0.67820409
99MP0003936_abnormal_reproductive_system0.67000391
100MP0005620_abnormal_muscle_contractility0.66823368
101MP0001614_abnormal_blood_vessel0.66270381
102MP0009780_abnormal_chondrocyte_physiolo0.65277700
103MP0005595_abnormal_vascular_smooth0.64958844
104MP0003942_abnormal_urinary_system0.63346991
105MP0010329_abnormal_lipoprotein_level0.63291968
106MP0003646_muscle_fatigue0.63193729
107MP0004130_abnormal_muscle_cell0.62971851
108MP0000003_abnormal_adipose_tissue0.62070173
109MP0003329_amyloid_beta_deposits0.62064580
110MP0003283_abnormal_digestive_organ0.61693039
111MP0002109_abnormal_limb_morphology0.61170802
112MP0001270_distended_abdomen0.60939951
113MP0002876_abnormal_thyroid_physiology0.60115343
114MP0010352_gastrointestinal_tract_polyps0.59898251
115MP0002933_joint_inflammation0.58841177
116MP0005197_abnormal_uvea_morphology0.58637662
117MP0000230_abnormal_systemic_arterial0.58631289
118MP0003937_abnormal_limbs/digits/tail_de0.57727102
119MP0005253_abnormal_eye_physiology0.53328654
120MP0000569_abnormal_digit_pigmentation0.53055773
121MP0003755_abnormal_palate_morphology0.51550501
122MP0001664_abnormal_digestion0.50288329
123MP0002111_abnormal_tail_morphology0.45678501
124MP0003183_abnormal_peptide_metabolism0.42638946
125MP0003950_abnormal_plasma_membrane0.40441867
126MP0000534_abnormal_ureter_morphology0.37445593
127MP0009115_abnormal_fat_cell0.37423077
128MP0001175_abnormal_lung_morphology0.36272159
129MP0002133_abnormal_respiratory_system0.35273606
130MP0005388_respiratory_system_phenotype0.35273606
131MP0001286_abnormal_eye_development0.34830577
132MP0005193_abnormal_anterior_eye0.32995805
133MP0000026_abnormal_inner_ear0.32517146
134MP0003938_abnormal_ear_development0.31956187
135MP0002177_abnormal_outer_ear0.31441137

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)8.87450985
2Metaphyseal dysplasia (HP:0100255)8.51396816
3Hypophosphatemic rickets (HP:0004912)7.70299192
4Gonadotropin excess (HP:0000837)7.35561175
5Abnormality of the vertebral endplates (HP:0005106)6.03782112
6Aortic dissection (HP:0002647)5.86467511
7Increased density of long bones (HP:0006392)5.79214733
8Premature rupture of membranes (HP:0001788)5.70821560
9Mild short stature (HP:0003502)5.63102700
10Protrusio acetabuli (HP:0003179)5.25167354
11Enlarged penis (HP:0000040)5.14702419
12Overgrowth (HP:0001548)5.13756737
13Ankle contracture (HP:0006466)4.99471792
14Aortic aneurysm (HP:0004942)4.96655888
15Abnormality of calcium-phosphate metabolism (HP:0100530)4.88045110
16Abnormal sex determination (HP:0012244)4.77552842
17Sex reversal (HP:0012245)4.77552842
18Irregular vertebral endplates (HP:0003301)4.75185268
19Broad ribs (HP:0000885)4.72804837
20Craniofacial hyperostosis (HP:0004493)4.63745978
21Enlarged epiphyses (HP:0010580)4.57175054
22Facial diplegia (HP:0001349)4.38155408
23Spondylolisthesis (HP:0003302)4.37036221
24Cerebral aneurysm (HP:0004944)4.26020327
25Broad metatarsal (HP:0001783)4.22900810
26Cranial hyperostosis (HP:0004437)4.01173874
27Arterial tortuosity (HP:0005116)3.95320387
28Type 1 muscle fiber predominance (HP:0003803)3.89967704
29Vascular tortuosity (HP:0004948)3.74294908
30Hyperpituitarism (HP:0010514)3.69716917
31Renal salt wasting (HP:0000127)3.66240348
32Soft skin (HP:0000977)3.58233657
33Atrophic scars (HP:0001075)3.43124507
34Spinal cord compression (HP:0002176)3.42309100
35Arthropathy (HP:0003040)3.37782267
36Follicular hyperkeratosis (HP:0007502)3.35696215
37Macroorchidism (HP:0000053)3.35354500
38Absent frontal sinuses (HP:0002688)3.27733995
39Rickets (HP:0002748)3.22563977
40Short hallux (HP:0010109)3.19948825
41Genu varum (HP:0002970)3.19033445
42Mitral valve prolapse (HP:0001634)3.15857781
43Osteomalacia (HP:0002749)3.11395336
44Wormian bones (HP:0002645)3.06600550
45Choanal stenosis (HP:0000452)3.03468664
46Aplasia/Hypoplasia of the hallux (HP:0008362)2.98595388
47Ulnar bowing (HP:0003031)2.92992237
48Cervical subluxation (HP:0003308)2.85385370
49Sudden death (HP:0001699)2.78225065
50Lymphangioma (HP:0100764)2.74510179
51Osteolytic defects of the phalanges of the hand (HP:0009771)2.74088399
52Osteolytic defects of the hand bones (HP:0009699)2.74088399
53Blue sclerae (HP:0000592)2.73469809
54Abnormal cartilage morphology (HP:0002763)2.72849618
55Increased connective tissue (HP:0009025)2.72513391
56Shallow orbits (HP:0000586)2.72001212
57Subacute progressive viral hepatitis (HP:0006572)2.71798508
58Small epiphyses (HP:0010585)2.69085218
59Dilatation of the ascending aorta (HP:0005111)2.68516515
60Fragile skin (HP:0001030)2.68023090
61Spinal rigidity (HP:0003306)2.67511102
62Delayed closure of the anterior fontanelle (HP:0001476)2.65752252
63Short middle phalanx of finger (HP:0005819)2.65508755
64Slender build (HP:0001533)2.65394490
65Neonatal short-limb short stature (HP:0008921)2.62803193
66Amelogenesis imperfecta (HP:0000705)2.62243952
67Abnormality of dentin (HP:0010299)2.60683666
68Radial bowing (HP:0002986)2.54844623
69Increased variability in muscle fiber diameter (HP:0003557)2.52953387
70Metaphyseal cupping (HP:0003021)2.52215809
71Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.49081941
72Striae distensae (HP:0001065)2.47762215
73Bladder diverticulum (HP:0000015)2.46192443
74Aneurysm (HP:0002617)2.43939367
75Hypophosphatemia (HP:0002148)2.38072428
76Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.34255766
77Abnormality of femoral epiphyses (HP:0006499)2.34255766
78Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)2.31249067
79Multiple enchondromatosis (HP:0005701)2.28035944
80Persistence of primary teeth (HP:0006335)2.26314689
81Femoral bowing (HP:0002980)2.23795042
82Abnormal delivery (HP:0001787)2.21093192
83Abnormality of skeletal muscle fiber size (HP:0012084)2.16966477
84Mildly elevated creatine phosphokinase (HP:0008180)2.16293055
85Abnormality of the middle phalanges of the hand (HP:0009833)2.15230577
86Rectal prolapse (HP:0002035)2.13212883
87Hyperextensible skin (HP:0000974)2.12735443
88Wrist flexion contracture (HP:0001239)2.12542832
89Peritonitis (HP:0002586)2.12388642
90Wide anterior fontanel (HP:0000260)2.11264787
91Aortic regurgitation (HP:0001659)2.09665015
92Tarsal synostosis (HP:0008368)2.08494576
93Tibial bowing (HP:0002982)2.07169563
94Joint laxity (HP:0001388)2.06450611
95Elbow flexion contracture (HP:0002987)2.05265133
96Skin nodule (HP:0200036)2.04191483
97Abnormality of the epiphysis of the femoral head (HP:0010574)2.04122606
98Broad long bones (HP:0005622)2.03670839
99Bowed forearm bones (HP:0003956)2.02485030
100Bowing of the arm (HP:0006488)2.02485030
101Abnormality of the frontal sinuses (HP:0002687)2.02149925
102Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.01866107
103Hyperaldosteronism (HP:0000859)2.01517987
104Delayed cranial suture closure (HP:0000270)2.00818966
105Papilledema (HP:0001085)11.1667366
106Biconcave vertebral bodies (HP:0004586)1.99279559
107Mesomelia (HP:0003027)1.97906630
108Genu recurvatum (HP:0002816)1.96251870
109Cupped ribs (HP:0000887)1.95588391
110Abnormality of Sharpey fibers (HP:0100685)1.95313161
111Asymmetry of the thorax (HP:0001555)1.93859473
112Bicuspid aortic valve (HP:0001647)1.93639578
113Platyspondyly (HP:0000926)1.93544291
114Knee flexion contracture (HP:0006380)1.92746961
115Complement deficiency (HP:0004431)1.92397283
116Flared iliac wings (HP:0002869)1.91739417
117Osteoarthritis (HP:0002758)1.89869712
118Abnormality of primary teeth (HP:0006481)1.87357923
119Abnormality of the femoral head (HP:0003368)1.86601913
120Exostoses (HP:0100777)1.86531039
121Abnormality of the ischium (HP:0003174)1.86212078
122Abnormality of the acetabulum (HP:0003170)1.85703244
123Buphthalmos (HP:0000557)1.85532876
124Elevated alkaline phosphatase (HP:0003155)1.84578221
125Hypoplastic ischia (HP:0003175)1.83778682
126Hyporeflexia of lower limbs (HP:0002600)1.83738131
127Neoplasm of the heart (HP:0100544)1.82905804
128Synostosis involving bones of the lower limbs (HP:0009138)1.82231993
129Synostosis involving bones of the feet (HP:0009140)1.82231993
130Aplasia involving bones of the upper limbs (HP:0009823)1.79151438
131Aplasia of the phalanges of the hand (HP:0009802)1.79151438
132Aplasia involving bones of the extremities (HP:0009825)1.79151438
133Vertebral compression fractures (HP:0002953)1.78776518
134Purpura (HP:0000979)1.78001076
135Decreased skull ossification (HP:0004331)1.77969475
136Broad phalanx (HP:0006009)1.76824978
137Muscle fiber splitting (HP:0003555)1.76304854
138Constricted visual fields (HP:0001133)1.76192848
139Narrow palate (HP:0000189)1.75981724
140Venous insufficiency (HP:0005293)1.75524152
141Ovoid vertebral bodies (HP:0003300)1.75318533
142Coxa vara (HP:0002812)1.75268002
143Hydroxyprolinuria (HP:0003080)1.75038421
144Abnormality of proline metabolism (HP:0010907)1.75038421
145Venous abnormality (HP:0002624)1.74844074
146Ridged nail (HP:0001807)1.72890119
147Metaphyseal irregularity (HP:0003025)1.72528221
148Progressive visual loss (HP:0000529)1.67937093
149Abnormality of the phalanges of the 2nd finger (HP:0009541)1.65964313
150Abnormal cortical bone morphology (HP:0003103)1.64362042
151Abnormality of alkaline phosphatase activity (HP:0004379)1.61147623
152Infantile muscular hypotonia (HP:0008947)1.60301612
153Abnormality of skull ossification (HP:0002703)1.60265452
154Short middle phalanx of the 5th finger (HP:0004220)1.58367506
155Hypoplastic scapulae (HP:0000882)1.56244809
156Aplasia/Hypoplasia of the scapulae (HP:0006713)1.56244809
157Abnormal enzyme/coenzyme activity (HP:0012379)1.54210409
158Broad phalanges of the hand (HP:0009768)1.50666390
159Back pain (HP:0003418)1.47896660
160Cardiovascular calcification (HP:0011915)1.47804850
161Short distal phalanx of finger (HP:0009882)1.47596984

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.79270674
2NLK4.74931313
3MYLK4.42893912
4TNIK4.23972048
5DDR24.20925907
6TGFBR23.92630729
7PDGFRA3.78310882
8PIK3CG2.85611543
9TRIB32.55467549
10LATS12.45379047
11SGK22.22365373
12FER2.14520727
13DMPK2.09278605
14NTRK22.01044150
15FGFR21.99499155
16PAK21.87993888
17PNCK1.79559633
18ERN11.57730787
19PDK21.57428250
20EPHA31.56277113
21LMTK21.54320789
22SGK31.52004747
23LIMK11.49762628
24SGK4941.43843979
25SGK2231.43843979
26MET1.42671168
27SIK11.42274252
28RIPK11.42256447
29PDGFRB1.40475665
30EPHB21.38985941
31TYK21.36900588
32AKT31.35662383
33CDC42BPA1.35192507
34STK38L1.34102325
35PAK31.33979842
36MST41.31948021
37MAPKAPK31.30875659
38LRRK21.30753594
39PIK3CA1.24448256
40MAP3K131.23759229
41TAF11.18433583
42FGFR11.18210017
43NTRK11.17040909
44RET1.15694544
45TESK11.14334750
46FGFR31.13098640
47MOS1.11025906
48PKN21.10954736
49FGFR41.07709576
50ROCK11.07565135
51KSR21.06970933
52MAPK121.05107971
53FRK1.04432526
54STK31.03414099
55IRAK11.01092037
56PTK61.00985525
57EPHB11.00483229
58LATS20.97836219
59MARK20.97286584
60TRPM70.95222705
61PAK10.92744532
62KIT0.90958176
63PTK2B0.90797913
64CDK60.90705540
65MAP3K20.88431374
66WNK10.88253317
67ERBB30.84113946
68ILK0.83301320
69PTK20.81545234
70PKN10.81176694
71STK240.79631055
72MAP2K10.79076903
73JAK20.75613059
74ROCK20.74101447
75MST1R0.73609794
76MAPKAPK50.73501410
77HIPK20.72472699
78PAK40.71657878
79STK390.69986159
80DYRK1A0.69464103
81CASK0.69067671
82MAPK150.65708414
83MAP3K60.65529164
84MAPK40.64767416
85KDR0.64614981
86GSK3A0.63615042
87CSNK1A1L0.63534649
88TGFBR10.63306435
89CSK0.62790586
90CSNK1G10.61092396
91MARK10.61012952
92MAPK70.60769241
93NEK90.60694519
94MAP3K120.59537019
95EEF2K0.59120766
96MTOR0.58460876
97NUAK10.56628918
98JAK10.56620526
99SRC0.54653340
100CDK80.53957829
101JAK30.53165082
102PHKG20.52745047
103PHKG10.52745047
104TYRO30.51991583
105TIE10.50972372
106PRKD10.50765118
107CAMK1G0.50430239
108NTRK30.49005353
109DAPK30.48464290
110SCYL20.47125302
111MAPK30.45577667
112CAMKK20.44532965
113CSF1R0.44176719
114PLK20.43904541
115RPS6KA20.43059782
116PRKAA20.42051870
117MAP3K70.41902902
118IGF1R0.41326898
119INSR0.41275036
120PRKCH0.39889245
121CAMK40.39340277
122FLT30.37725023
123PRKCE0.37611432
124PRKG10.37505876
125BMX0.37458079
126ERBB20.37251526
127CAMK10.36817275
128BCR0.36754039
129ADRBK10.35682288
130ABL20.35462153
131TAOK30.35070668
132ADRBK20.35034402
133MAPK10.34316480
134PAK60.33380555
135CDK90.33230079
136CAMK2G0.31975359
137PDPK10.31675851
138ABL10.30670484
139DYRK1B0.29206106
140STK380.28241402
141TAOK10.28142997
142CAMK1D0.26745527

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049136.43142997
2ECM-receptor interaction_Homo sapiens_hsa045124.20618273
3Steroid hormone biosynthesis_Homo sapiens_hsa001404.15092076
4Focal adhesion_Homo sapiens_hsa045102.56811423
5Aldosterone synthesis and secretion_Homo sapiens_hsa049252.49525372
6TGF-beta signaling pathway_Homo sapiens_hsa043502.14649888
7Amoebiasis_Homo sapiens_hsa051461.90439692
8Protein digestion and absorption_Homo sapiens_hsa049741.89309806
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.74547292
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.70735684
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.70465014
12Proteoglycans in cancer_Homo sapiens_hsa052051.67894354
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.60154291
14Dilated cardiomyopathy_Homo sapiens_hsa054141.59599991
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.53608328
16Complement and coagulation cascades_Homo sapiens_hsa046101.47537801
17* Wnt signaling pathway_Homo sapiens_hsa043101.37424138
18Vascular smooth muscle contraction_Homo sapiens_hsa042701.35548914
19Malaria_Homo sapiens_hsa051441.30127111
20PI3K-Akt signaling pathway_Homo sapiens_hsa041511.28018810
21Fatty acid biosynthesis_Homo sapiens_hsa000611.24364424
22Steroid biosynthesis_Homo sapiens_hsa001001.17474491
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.16239624
24PPAR signaling pathway_Homo sapiens_hsa033201.14513240
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10683876
26Thyroid hormone synthesis_Homo sapiens_hsa049181.07213036
27Chronic myeloid leukemia_Homo sapiens_hsa052201.05479698
28Hippo signaling pathway_Homo sapiens_hsa043901.04921963
29Staphylococcus aureus infection_Homo sapiens_hsa051501.04776843
30Prolactin signaling pathway_Homo sapiens_hsa049171.04226912
31Circadian rhythm_Homo sapiens_hsa047101.03516493
32Caffeine metabolism_Homo sapiens_hsa002321.02312781
33Small cell lung cancer_Homo sapiens_hsa052221.02297777
34Estrogen signaling pathway_Homo sapiens_hsa049150.99089056
35Lysosome_Homo sapiens_hsa041420.97200670
36Adherens junction_Homo sapiens_hsa045200.96156173
37Basal cell carcinoma_Homo sapiens_hsa052170.91746457
38Fatty acid degradation_Homo sapiens_hsa000710.91177078
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90721108
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88805788
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88737942
42MicroRNAs in cancer_Homo sapiens_hsa052060.88696549
43Toxoplasmosis_Homo sapiens_hsa051450.88250089
44Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88110779
45Nitrogen metabolism_Homo sapiens_hsa009100.87577348
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86298607
47Fatty acid metabolism_Homo sapiens_hsa012120.85268088
48Phagosome_Homo sapiens_hsa041450.84012977
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82965851
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82160530
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81048201
52Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80794698
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79907815
54Hedgehog signaling pathway_Homo sapiens_hsa043400.79512649
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.78311774
56Pancreatic cancer_Homo sapiens_hsa052120.75710374
57Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74365660
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74080859
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73447202
60Glioma_Homo sapiens_hsa052140.71710728
61Renin secretion_Homo sapiens_hsa049240.70352768
62Platelet activation_Homo sapiens_hsa046110.69612703
63Colorectal cancer_Homo sapiens_hsa052100.69110905
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.66258705
65Glutathione metabolism_Homo sapiens_hsa004800.64952070
66Pathways in cancer_Homo sapiens_hsa052000.63813869
67Oxytocin signaling pathway_Homo sapiens_hsa049210.63554129
68Osteoclast differentiation_Homo sapiens_hsa043800.63505254
69Gap junction_Homo sapiens_hsa045400.63406760
70mTOR signaling pathway_Homo sapiens_hsa041500.62303914
71Insulin resistance_Homo sapiens_hsa049310.62220608
72Calcium signaling pathway_Homo sapiens_hsa040200.61952921
73Prostate cancer_Homo sapiens_hsa052150.61482062
74Collecting duct acid secretion_Homo sapiens_hsa049660.60577592
75Renal cell carcinoma_Homo sapiens_hsa052110.59854418
76Melanogenesis_Homo sapiens_hsa049160.59599070
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58069579
78ABC transporters_Homo sapiens_hsa020100.56932132
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.56899134
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56042167
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55830777
82Axon guidance_Homo sapiens_hsa043600.55455218
83Arachidonic acid metabolism_Homo sapiens_hsa005900.55276944
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55076233
85Rap1 signaling pathway_Homo sapiens_hsa040150.54693381
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.54386973
87GnRH signaling pathway_Homo sapiens_hsa049120.51871569
88AMPK signaling pathway_Homo sapiens_hsa041520.51228184
89Lysine degradation_Homo sapiens_hsa003100.49809888
90FoxO signaling pathway_Homo sapiens_hsa040680.49512496
91Tight junction_Homo sapiens_hsa045300.49315347
92Gastric acid secretion_Homo sapiens_hsa049710.49046477
93Bile secretion_Homo sapiens_hsa049760.48728220
94Arginine and proline metabolism_Homo sapiens_hsa003300.48372548
95ErbB signaling pathway_Homo sapiens_hsa040120.48183981
96Ras signaling pathway_Homo sapiens_hsa040140.48031030
97MAPK signaling pathway_Homo sapiens_hsa040100.47430946
98Vibrio cholerae infection_Homo sapiens_hsa051100.47104199
99Choline metabolism in cancer_Homo sapiens_hsa052310.47076296
100Melanoma_Homo sapiens_hsa052180.46012130
101Viral myocarditis_Homo sapiens_hsa054160.45820203
102Long-term depression_Homo sapiens_hsa047300.44026219
103Pertussis_Homo sapiens_hsa051330.43785785
104Rheumatoid arthritis_Homo sapiens_hsa053230.43283372
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43264682
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43195640
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42949477
108Pancreatic secretion_Homo sapiens_hsa049720.42689429
109Dorso-ventral axis formation_Homo sapiens_hsa043200.42681818
110Cholinergic synapse_Homo sapiens_hsa047250.40395651
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40143689
112Tuberculosis_Homo sapiens_hsa051520.39727691
113cAMP signaling pathway_Homo sapiens_hsa040240.38110699
114Thyroid cancer_Homo sapiens_hsa052160.37171387
115Prion diseases_Homo sapiens_hsa050200.37111762
116Chemokine signaling pathway_Homo sapiens_hsa040620.36669288
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36027622
118Salmonella infection_Homo sapiens_hsa051320.35365265
119Insulin signaling pathway_Homo sapiens_hsa049100.34738662
120Notch signaling pathway_Homo sapiens_hsa043300.34422769
121Endometrial cancer_Homo sapiens_hsa052130.34035604
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.33493389
123Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32307042
124Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30649794
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30582988
126Other glycan degradation_Homo sapiens_hsa005110.30433546
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30418262
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.30166797
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29792645
130Leishmaniasis_Homo sapiens_hsa051400.29727206
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28839762

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »