SFRP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)8.64202701
2Golgi transport vesicle coating (GO:0048200)8.64202701
3vitamin A metabolic process (GO:0006776)7.77703773
4response to dietary excess (GO:0002021)7.27678876
5peptide hormone processing (GO:0016486)6.08970752
6retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.91170149
7maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.71017263
8positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003575.63299965
9protein retention in ER lumen (GO:0006621)5.61182143
10L-alpha-amino acid transmembrane transport (GO:1902475)5.60200038
11regulation of cardioblast differentiation (GO:0051890)5.28642106
12COPII vesicle coating (GO:0048208)4.86214519
13negative regulation of digestive system process (GO:0060457)4.84570024
14regulation of cholesterol esterification (GO:0010872)4.82345620
15glucocorticoid biosynthetic process (GO:0006704)4.79853191
16positive regulation of insulin secretion (GO:0032024)4.55735741
17regulation of bile acid biosynthetic process (GO:0070857)4.52988387
18positive regulation of astrocyte differentiation (GO:0048711)4.48445404
19endocrine pancreas development (GO:0031018)4.42052242
20atrioventricular valve morphogenesis (GO:0003181)4.40992424
21cell-cell junction maintenance (GO:0045217)4.40624265
22cell junction maintenance (GO:0034331)4.31161343
23toxin metabolic process (GO:0009404)4.19630308
24lung lobe morphogenesis (GO:0060463)4.16387672
25glandular epithelial cell differentiation (GO:0002067)4.10559220
26positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)4.08002146
27regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.04002261
28positive regulation of vesicle fusion (GO:0031340)4.03782707
29regulation of transforming growth factor beta2 production (GO:0032909)4.00920862
30regulation of cholesterol homeostasis (GO:2000188)3.97480021
31insulin secretion (GO:0030073)3.89665301
32regulation of penile erection (GO:0060405)3.89301448
33outflow tract septum morphogenesis (GO:0003148)3.87809208
34positive regulation of synaptic transmission, GABAergic (GO:0032230)3.86470329
35calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.82092318
36signal peptide processing (GO:0006465)3.80229935
37angiotensin maturation (GO:0002003)3.79621753
38regulation of triglyceride catabolic process (GO:0010896)3.78744089
39glucocorticoid metabolic process (GO:0008211)3.77947587
40high-density lipoprotein particle remodeling (GO:0034375)3.76522986
41sulfation (GO:0051923)3.75637864
42regulation of type B pancreatic cell apoptotic process (GO:2000674)3.74992924
43cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.72903859
44activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.72662479
45artery smooth muscle contraction (GO:0014824)3.72229614
46protein maturation by protein folding (GO:0022417)3.68401538
47protein autoprocessing (GO:0016540)3.66249056
48cellular response to vitamin (GO:0071295)3.66014924
49plasma lipoprotein particle remodeling (GO:0034369)3.65977274
50protein-lipid complex remodeling (GO:0034368)3.65977274
51macromolecular complex remodeling (GO:0034367)3.65977274
52positive regulation of peptide hormone secretion (GO:0090277)3.65242064
53vesicle coating (GO:0006901)3.62421211
54bundle of His cell to Purkinje myocyte communication (GO:0086069)3.58865673
55nitric oxide mediated signal transduction (GO:0007263)3.58758220
56sequestering of metal ion (GO:0051238)3.58689259
57eating behavior (GO:0042755)3.57254072
58positive regulation of peptide secretion (GO:0002793)3.54324937
59positive regulation of extracellular matrix organization (GO:1903055)3.52200206
60phospholipid efflux (GO:0033700)3.50474578
61negative regulation of execution phase of apoptosis (GO:1900118)3.50326083
62regulation of insulin secretion (GO:0050796)3.50150381
63positive regulation of triglyceride metabolic process (GO:0090208)3.50009855
64regulation of uterine smooth muscle contraction (GO:0070472)3.49861178
65cardiac muscle adaptation (GO:0014887)3.49593222
66cardiac muscle hypertrophy in response to stress (GO:0014898)3.49593222
67muscle hypertrophy in response to stress (GO:0003299)3.49593222
68positive regulation of amino acid transport (GO:0051957)3.48717315
69positive regulation of nuclease activity (GO:0032075)3.48516075
70epoxygenase P450 pathway (GO:0019373)3.47923803
71otic vesicle formation (GO:0030916)3.46589175
72peptide hormone secretion (GO:0030072)3.45505244
73positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.40084275
74peptide secretion (GO:0002790)3.40014016
75regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)3.39364353
76positive regulation of uterine smooth muscle contraction (GO:0070474)3.38765236
77cellular response to vitamin D (GO:0071305)3.37953942
78sodium-independent organic anion transport (GO:0043252)3.37199363
79low-density lipoprotein particle clearance (GO:0034383)3.36137720
80adhesion of symbiont to host (GO:0044406)3.32566597
81protein-chromophore linkage (GO:0018298)3.32015311
82production of molecular mediator involved in inflammatory response (GO:0002532)3.30247447
83tonic smooth muscle contraction (GO:0014820)3.30029239
84regulation of complement activation (GO:0030449)3.29513893
85positive regulation of hormone secretion (GO:0046887)3.25473306
86regulation of protein activation cascade (GO:2000257)3.25082282
87epithelial cell fate commitment (GO:0072148)3.19013268
88regulation of norepinephrine secretion (GO:0014061)3.18370103
89regulation of peptide hormone secretion (GO:0090276)3.15101746
90response to mercury ion (GO:0046689)3.14600451
91cellular response to glucagon stimulus (GO:0071377)3.13792699
92regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.13095586
93positive regulation of catecholamine secretion (GO:0033605)3.13053800
94regulation of nuclease activity (GO:0032069)3.11380424
95regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.10743270
96plasma lipoprotein particle clearance (GO:0034381)3.10093465
97regulation of peptide secretion (GO:0002791)3.09738922
98reverse cholesterol transport (GO:0043691)3.09428924
99cardiac muscle hypertrophy (GO:0003300)3.07446484
100regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.03172491
101keratan sulfate catabolic process (GO:0042340)3.02755780
102growth hormone secretion (GO:0030252)3.01586077
103suckling behavior (GO:0001967)3.01532216
104endoplasmic reticulum unfolded protein response (GO:0030968)2.99895984
105endocrine process (GO:0050886)2.98320471
106regulation of systemic arterial blood pressure by hormone (GO:0001990)2.98320471
107regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.98320471
108fat-soluble vitamin metabolic process (GO:0006775)2.95589191
109triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.95376546
110regulation of amyloid precursor protein catabolic process (GO:1902991)2.94744858
111epithelial cell-cell adhesion (GO:0090136)2.94627342
112cellular zinc ion homeostasis (GO:0006882)2.93310618
113cellular response to unfolded protein (GO:0034620)2.92458128
114intra-Golgi vesicle-mediated transport (GO:0006891)2.92357453
115membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.92082702
116ER to Golgi vesicle-mediated transport (GO:0006888)2.91971333
117regulation of triglyceride metabolic process (GO:0090207)2.91807429
118negative regulation of complement activation (GO:0045916)2.91409220
119complement activation, alternative pathway (GO:0006957)2.91059820
120striated muscle hypertrophy (GO:0014897)2.90542393
121cardiac myofibril assembly (GO:0055003)2.88822002
122regulation of transforming growth factor beta1 production (GO:0032908)2.87649630
123cellular response to topologically incorrect protein (GO:0035967)2.87324528
124glandular epithelial cell development (GO:0002068)2.86550435
125low-density lipoprotein particle remodeling (GO:0034374)2.86404898
126regulation of extracellular matrix organization (GO:1903053)2.86156633
127regulation of hormone secretion (GO:0046883)2.85635978
128lung epithelium development (GO:0060428)2.84435479
129positive regulation of calcium ion import (GO:0090280)2.84316327
130peptide transport (GO:0015833)2.83049602
131cell volume homeostasis (GO:0006884)2.82699601
132type B pancreatic cell development (GO:0003323)2.82268235
133branching involved in salivary gland morphogenesis (GO:0060445)2.80525690
134leukocyte tethering or rolling (GO:0050901)2.79957721
135peptide catabolic process (GO:0043171)2.79151790
136hormone secretion (GO:0046879)2.78397580
137membrane repolarization during action potential (GO:0086011)2.77635547
138response to follicle-stimulating hormone (GO:0032354)2.77272150
139regulation of beta-amyloid formation (GO:1902003)2.77198654
140ER-nucleus signaling pathway (GO:0006984)2.76592860
141hormone catabolic process (GO:0042447)2.76543769
142cellular response to gonadotropin stimulus (GO:0071371)2.76141697
143plasma lipoprotein particle organization (GO:0071827)2.75662194
144ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.75448137
145positive regulation of cardiac muscle cell proliferation (GO:0060045)2.75439303
146positive regulation of amine transport (GO:0051954)2.75242928
147negative regulation of glycoprotein biosynthetic process (GO:0010561)2.75013881
148amyloid precursor protein catabolic process (GO:0042987)2.74491642
149plasma lipoprotein particle assembly (GO:0034377)2.74163214
150sleep (GO:0030431)2.73558688
151exocrine pancreas development (GO:0031017)2.73050176
152cellular response to nitric oxide (GO:0071732)2.72355959
153protein-lipid complex subunit organization (GO:0071825)2.71296438
154myofibril assembly (GO:0030239)2.70508861
155regulation of steroid hormone biosynthetic process (GO:0090030)2.70454510
156negative regulation of fatty acid transport (GO:2000192)2.69789813
157peptide metabolic process (GO:0006518)2.69639345
158phosphate ion transmembrane transport (GO:0035435)2.69522401
159positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.68781144
160cellular component maintenance (GO:0043954)2.67951495
161positive regulation of fatty acid biosynthetic process (GO:0045723)2.66926103
162protein-lipid complex assembly (GO:0065005)2.66325882
163positive regulation of p38MAPK cascade (GO:1900745)2.66153044
164GDP-mannose metabolic process (GO:0019673)2.65737127
165renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.65268024
166cellular response to leptin stimulus (GO:0044320)2.64517114
167macroautophagy (GO:0016236)2.64455478
168hormone transport (GO:0009914)2.63941229
169regulation of extracellular matrix disassembly (GO:0010715)2.63279115
170proline biosynthetic process (GO:0006561)2.62963547
171lipoprotein metabolic process (GO:0042157)2.62648555
172* negative regulation of catenin import into nucleus (GO:0035414)2.62455380
173negative regulation of coagulation (GO:0050819)2.62283312
174negative regulation of sterol transport (GO:0032372)2.62218966
175negative regulation of cholesterol transport (GO:0032375)2.62218966
176very-low-density lipoprotein particle assembly (GO:0034379)2.62041333
177positive regulation of steroid metabolic process (GO:0045940)2.61272150
178negative regulation of lipase activity (GO:0060192)2.59203327
179astrocyte differentiation (GO:0048708)2.58369928
180cellular response to reactive nitrogen species (GO:1902170)2.58231830
181regulation of p38MAPK cascade (GO:1900744)2.57905467
182transepithelial transport (GO:0070633)2.57894826
183regulation of plasminogen activation (GO:0010755)2.56606718
184detection of calcium ion (GO:0005513)2.55865100
185response to lipoprotein particle (GO:0055094)2.55538064
186mesenchymal cell proliferation (GO:0010463)2.55426688
187cholesterol efflux (GO:0033344)2.55383862
188neuron fate specification (GO:0048665)2.55162741
189positive regulation of gluconeogenesis (GO:0045722)2.55091161
190negative regulation of hemostasis (GO:1900047)2.54544784
191negative regulation of blood coagulation (GO:0030195)2.54544784
192muscle hypertrophy (GO:0014896)2.54110432
193negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.53157281
194sarcomere organization (GO:0045214)2.52615559
195regulation of peptide transport (GO:0090087)2.52364763
196regulation of digestive system process (GO:0044058)2.50884902
197Golgi organization (GO:0007030)2.50286588

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.66557921
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.29324264
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.14003972
4GATA1_22025678_ChIP-Seq_K562_Human3.01083459
5CDX2_20551321_ChIP-Seq_CACO-2_Human2.74086050
6ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.68217190
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.52680312
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.34131405
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.04104927
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03424616
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.02706614
12ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.94882955
13EGR1_19374776_ChIP-ChIP_THP-1_Human1.91426148
14NR3C1_23031785_ChIP-Seq_PC12_Mouse1.88429933
15PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.86184315
16CLOCK_20551151_ChIP-Seq_293T_Human1.79627088
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.77721482
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73139092
19EGR1_23403033_ChIP-Seq_LIVER_Mouse1.70194352
20SOX2_27498859_Chip-Seq_STOMACH_Mouse1.66631852
21EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.64712194
22BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.64633229
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.59813455
24* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.59602324
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58380526
26FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.56286365
27TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52860624
28RACK7_27058665_Chip-Seq_MCF-7_Human1.51930085
29* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.48054210
30* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.48029417
31SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.48018241
32KDM2B_26808549_Chip-Seq_K562_Human1.47941512
33LXR_22158963_ChIP-Seq_LIVER_Mouse1.47876577
34SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.45868752
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.43088211
36DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.39746273
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39586627
38* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.39500074
39SOX2_20726797_ChIP-Seq_SW620_Human1.38124860
40TP63_17297297_ChIP-ChIP_HaCaT_Human1.37325538
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.35755368
42RXR_22158963_ChIP-Seq_LIVER_Mouse1.34323934
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.31912958
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.30322767
45GATA6_25053715_ChIP-Seq_YYC3_Human1.29134481
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.27744663
47KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27436536
48KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27189918
49REST_18959480_ChIP-ChIP_MESCs_Mouse1.26748137
50ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25755101
51* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25692303
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25668914
53PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24186580
54WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24018111
55ESR1_20079471_ChIP-ChIP_T-47D_Human1.22985918
56ELK3_25401928_ChIP-Seq_HUVEC_Human1.22453186
57EP300_21415370_ChIP-Seq_HL-1_Mouse1.21612923
58LXR_22292898_ChIP-Seq_THP-1_Human1.20050392
59GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.19097327
60IGF1R_20145208_ChIP-Seq_DFB_Human1.15380573
61AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.15309849
62RUNX1_27514584_Chip-Seq_MCF-7_Human1.14420747
63GATA4_25053715_ChIP-Seq_YYC3_Human1.14215468
64* ISL1_27105846_Chip-Seq_CPCs_Mouse1.13784624
65SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13390815
66SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12974611
67TBX20_22328084_ChIP-Seq_HEART_Mouse1.12939280
68TBX20_22080862_ChIP-Seq_HEART_Mouse1.12939280
69CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12468671
70* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12029103
71ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11349664
72RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10388831
73RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10148749
74ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09539588
75CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09229311
76STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08528685
77RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08402294
78REST_21632747_ChIP-Seq_MESCs_Mouse1.07703812
79PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06773203
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.06628143
81PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06504450
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05769735
83* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04788297
84GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04597411
85* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.02979194
86WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02916472
87NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02627681
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02169253
89ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01895420
90FOXH1_21741376_ChIP-Seq_ESCs_Human1.00420528
91* EED_16625203_ChIP-ChIP_MESCs_Mouse1.00410761
92FOXA1_25552417_ChIP-Seq_VCAP_Human1.00239977
93P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98780871
94GATA3_24758297_ChIP-Seq_MCF-7_Human0.98547970
95GATA2_21666600_ChIP-Seq_HMVEC_Human0.98477683
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98267034
97DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97867052
98* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97815581
99ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97021980
100TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.96860103
101FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.96646249
102* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96233409
103* EZH2_27304074_Chip-Seq_ESCs_Mouse0.95254110
104REST_19997604_ChIP-ChIP_NEURONS_Mouse0.95178090
105TP63_22573176_ChIP-Seq_HFKS_Human0.94939284
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93268558
107CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.92281268
108* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.92262379
109CTCF_27219007_Chip-Seq_Bcells_Human0.91326689
110NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90086186
111FOXA2_19822575_ChIP-Seq_HepG2_Human0.90076459
112KLF4_19829295_ChIP-Seq_ESCs_Human0.89796832
113TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89713939
114NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.89329641
115* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.87495643
116* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.87495643
117TCF3_18692474_ChIP-Seq_MEFs_Mouse0.87401135
118ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87089627
119ELK4_26923725_Chip-Seq_MESODERM_Mouse0.86918018
120PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.86877461
121HNF4A_19822575_ChIP-Seq_HepG2_Human0.86748066
122TCF7_22412390_ChIP-Seq_EML_Mouse0.86655157
123ERG_21242973_ChIP-ChIP_JURKAT_Human0.86578535
124* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85419630
125KDM2B_26808549_Chip-Seq_DND41_Human0.85324595
126PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85254426
127VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84913521
128KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84760819
129ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84440957
130* GATA2_19941826_ChIP-Seq_K562_Human0.84394424
131FOXA1_27270436_Chip-Seq_PROSTATE_Human0.83296922
132FOXA1_25329375_ChIP-Seq_VCAP_Human0.83296922
133MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.83209549
134HIF1A_21447827_ChIP-Seq_MCF-7_Human0.81528663
135CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.81207168
136SOX2_21211035_ChIP-Seq_LN229_Gbm0.80190461
137PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.79983360
138FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.79659861
139FOXA1_21572438_ChIP-Seq_LNCaP_Human0.79214419
140DROSHA_22980978_ChIP-Seq_HELA_Human0.78445343
141ZNF274_21170338_ChIP-Seq_K562_Hela0.78159958
142* AR_19668381_ChIP-Seq_PC3_Human0.77231971
143SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.76830915
144ERG_20517297_ChIP-Seq_VCAP_Human0.76681987
145SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76556168
146* SMAD4_21741376_ChIP-Seq_HESCs_Human0.76421873
147DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.75676640
148WT1_19549856_ChIP-ChIP_CCG9911_Human0.75315165
149* GATA1_19941826_ChIP-Seq_K562_Human0.75086976
150CREB1_26743006_Chip-Seq_LNCaP_Human0.74074323
151CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.73944916
152BCAT_22108803_ChIP-Seq_LS180_Human0.73662750

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation7.45330253
2MP0000013_abnormal_adipose_tissue5.93974053
3MP0000566_synostosis5.38581460
4MP0005379_endocrine/exocrine_gland_phen4.95324158
5MP0002909_abnormal_adrenal_gland4.61736571
6MP0002837_dystrophic_cardiac_calcinosis4.21648676
7MP0003183_abnormal_peptide_metabolism4.20907176
8MP0000003_abnormal_adipose_tissue3.99754061
9MP0002139_abnormal_hepatobiliary_system3.29488018
10MP0005365_abnormal_bile_salt3.03229843
11MP0003195_calcinosis3.01554053
12MP0005670_abnormal_white_adipose2.90409739
13MP0005645_abnormal_hypothalamus_physiol2.84023314
14MP0010030_abnormal_orbit_morphology2.69602486
15MP0005360_urolithiasis2.62022864
16MP0002877_abnormal_melanocyte_morpholog2.58829039
17MP0001944_abnormal_pancreas_morphology2.56293506
18MP0005375_adipose_tissue_phenotype2.47252792
19MP0002928_abnormal_bile_duct2.45710018
20MP0008004_abnormal_stomach_pH2.41624279
21MP0001666_abnormal_nutrient_absorption2.40079368
22MP0003122_maternal_imprinting2.23787441
23MP0003283_abnormal_digestive_organ2.22496207
24MP0010386_abnormal_urinary_bladder2.18947009
25MP0000537_abnormal_urethra_morphology2.16064099
26MP0003252_abnormal_bile_duct2.12336369
27MP0004270_analgesia2.12210102
28MP0009780_abnormal_chondrocyte_physiolo2.08569646
29MP0002693_abnormal_pancreas_physiology2.03092663
30MP0005085_abnormal_gallbladder_physiolo1.95872990
31MP0004043_abnormal_pH_regulation1.86423626
32MP0002163_abnormal_gland_morphology1.81572072
33MP0003959_abnormal_lean_body1.80759758
34MP0002638_abnormal_pupillary_reflex1.78655568
35MP0001756_abnormal_urination1.78013254
36MP0000678_abnormal_parathyroid_gland1.76403417
37MP0003943_abnormal_hepatobiliary_system1.72342507
38MP0002078_abnormal_glucose_homeostasis1.71479741
39MP0004130_abnormal_muscle_cell1.68654402
40MP0002733_abnormal_thermal_nociception1.65208743
41MP0003123_paternal_imprinting1.58389359
42MP0001346_abnormal_lacrimal_gland1.56750955
43MP0001986_abnormal_taste_sensitivity1.52154130
44MP0001270_distended_abdomen1.49174002
45MP0004858_abnormal_nervous_system1.48914775
46MP0008438_abnormal_cutaneous_collagen1.44376757
47MP0005220_abnormal_exocrine_pancreas1.42794706
48MP0004084_abnormal_cardiac_muscle1.41945245
49MP0001765_abnormal_ion_homeostasis1.38099832
50MP0010368_abnormal_lymphatic_system1.38060504
51MP0005409_darkened_coat_color1.35258527
52MP0001299_abnormal_eye_distance/1.32401688
53MP0003172_abnormal_lysosome_physiology1.30726349
54MP0004272_abnormal_basement_membrane1.29395393
55MP0002734_abnormal_mechanical_nocicepti1.29247036
56MP0005058_abnormal_lysosome_morphology1.28726322
57MP0006276_abnormal_autonomic_nervous1.28567919
58MP0005666_abnormal_adipose_tissue1.26461264
59MP0002751_abnormal_autonomic_nervous1.25697912
60MP0002896_abnormal_bone_mineralization1.25115421
61MP0008875_abnormal_xenobiotic_pharmacok1.25038819
62MP0003878_abnormal_ear_physiology1.24073490
63MP0005377_hearing/vestibular/ear_phenot1.24073490
64MP0008961_abnormal_basal_metabolism1.22110862
65MP0003045_fibrosis1.21242265
66MP0005330_cardiomyopathy1.21113013
67MP0003566_abnormal_cell_adhesion1.20062894
68MP0004185_abnormal_adipocyte_glucose1.14330884
69MP0003787_abnormal_imprinting1.11843623
70MP0006138_congestive_heart_failure1.11030655
71MP0003953_abnormal_hormone_level1.10280943
72MP0009643_abnormal_urine_homeostasis1.10071458
73MP0005508_abnormal_skeleton_morphology1.10015824
74MP0001970_abnormal_pain_threshold1.08553705
75MP0010630_abnormal_cardiac_muscle1.08425904
76MP0002234_abnormal_pharynx_morphology1.08420859
77MP0005448_abnormal_energy_balance1.07095016
78MP0000639_abnormal_adrenal_gland1.04959813
79MP0009840_abnormal_foam_cell1.04235409
80MP0004019_abnormal_vitamin_homeostasis1.03162599
81MP0000749_muscle_degeneration1.01729026
82MP0002735_abnormal_chemical_nociception1.01570268
83MP0004215_abnormal_myocardial_fiber1.00029391
84MP0005083_abnormal_biliary_tract0.98000870
85MP0002249_abnormal_larynx_morphology0.97179290
86MP0008775_abnormal_heart_ventricle0.96914401
87MP0004233_abnormal_muscle_weight0.96467157
88MP0003300_gastrointestinal_ulcer0.95371670
89MP0006054_spinal_hemorrhage0.94918500
90MP0002971_abnormal_brown_adipose0.94619599
91MP0002089_abnormal_postnatal_growth/wei0.94131033
92MP0000230_abnormal_systemic_arterial0.92955905
93MP0001661_extended_life_span0.92366448
94MP0002127_abnormal_cardiovascular_syste0.92262144
95MP0004145_abnormal_muscle_electrophysio0.92075460
96MP0005535_abnormal_body_temperature0.91502613
97MP0004036_abnormal_muscle_relaxation0.90855896
98MP0003329_amyloid_beta_deposits0.89868929
99MP0003279_aneurysm0.88647074
100MP0002876_abnormal_thyroid_physiology0.87663478
101MP0005023_abnormal_wound_healing0.86615479
102MP0002108_abnormal_muscle_morphology0.86221134
103MP0002269_muscular_atrophy0.85813045
104MP0006072_abnormal_retinal_apoptosis0.85703639
105MP0005636_abnormal_mineral_homeostasis0.84443254
106MP0005275_abnormal_skin_tensile0.83766075
107MP0000462_abnormal_digestive_system0.82550759
108MP0002938_white_spotting0.82535164
109MP0004264_abnormal_extraembryonic_tissu0.82479727
110MP0000613_abnormal_salivary_gland0.79894301
111MP0005334_abnormal_fat_pad0.78879999
112MP0009384_cardiac_valve_regurgitation0.78542256
113MP0002168_other_aberrant_phenotype0.77840092
114MP0002736_abnormal_nociception_after0.77492875
115MP0003941_abnormal_skin_development0.75833476
116MP0003121_genomic_imprinting0.75540585
117MP0003633_abnormal_nervous_system0.75012594
118MP0002972_abnormal_cardiac_muscle0.74107426
119MP0003690_abnormal_glial_cell0.73388543
120MP0001501_abnormal_sleep_pattern0.72614275
121MP0000163_abnormal_cartilage_morphology0.71820884
122MP0002970_abnormal_white_adipose0.71196609
123MP0005166_decreased_susceptibility_to0.70531784
124MP0000751_myopathy0.70119196
125MP0002118_abnormal_lipid_homeostasis0.69402692
126MP0001968_abnormal_touch/_nociception0.68946947
127MP0001664_abnormal_digestion0.68824783
128MP0010329_abnormal_lipoprotein_level0.68632136
129MP0000767_abnormal_smooth_muscle0.68399894
130MP0005452_abnormal_adipose_tissue0.67557146
131MP0003567_abnormal_fetal_cardiomyocyte0.67466380
132MP0000609_abnormal_liver_physiology0.67158728
133MP0005253_abnormal_eye_physiology0.66903862
134MP0002998_abnormal_bone_remodeling0.65956003
135MP0000538_abnormal_urinary_bladder0.65259566
136MP0001958_emphysema0.64805670
137MP0003879_abnormal_hair_cell0.64747090
138MP0000249_abnormal_blood_vessel0.63452548
139MP0000747_muscle_weakness0.62993956
140MP0005332_abnormal_amino_acid0.62718597
141MP0004087_abnormal_muscle_fiber0.62669877
142MP0003705_abnormal_hypodermis_morpholog0.61527399
143MP0005257_abnormal_intraocular_pressure0.61385014
144MP0002933_joint_inflammation0.61113084
145MP0004885_abnormal_endolymph0.60602827
146MP0005084_abnormal_gallbladder_morpholo0.60449996
147MP0001529_abnormal_vocalization0.60050442
148MP0001544_abnormal_cardiovascular_syste0.59230999
149MP0005385_cardiovascular_system_phenoty0.59230999
150MP0003634_abnormal_glial_cell0.59079404
151MP0000604_amyloidosis0.58950138
152MP0002138_abnormal_hepatobiliary_system0.57801412
153MP0003191_abnormal_cellular_cholesterol0.57786951
154MP0001764_abnormal_homeostasis0.56935619
155MP0003828_pulmonary_edema0.56435180
156MP0004883_abnormal_blood_vessel0.55645978
157MP0002932_abnormal_joint_morphology0.55524763
158MP0003115_abnormal_respiratory_system0.54991706
159MP0003868_abnormal_feces_composition0.54711012
160MP0004085_abnormal_heartbeat0.54079949
161MP0000477_abnormal_intestine_morphology0.52236702
162MP0005595_abnormal_vascular_smooth0.51383447
163MP0000534_abnormal_ureter_morphology0.51342551
164MP0001879_abnormal_lymphatic_vessel0.50695964
165MP0003091_abnormal_cell_migration0.49480327

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)7.57440158
2Hyperinsulinemic hypoglycemia (HP:0000825)6.15396109
3Abnormality of calcium-phosphate metabolism (HP:0100530)5.66894896
4Hypoglycemic seizures (HP:0002173)5.36445369
5Hypoglycemic coma (HP:0001325)5.01513367
6Hyperglycemia (HP:0003074)4.95471392
7Symptomatic seizures (HP:0011145)4.69725965
8Potter facies (HP:0002009)4.46505145
9Facial shape deformation (HP:0011334)4.46505145
10Late onset (HP:0003584)4.29328371
11Pancreatic islet-cell hyperplasia (HP:0004510)4.26975597
12Agitation (HP:0000713)4.18803022
13Large for gestational age (HP:0001520)4.10325429
14Aplasia involving bones of the upper limbs (HP:0009823)4.03988315
15Aplasia of the phalanges of the hand (HP:0009802)4.03988315
16Aplasia involving bones of the extremities (HP:0009825)4.03988315
17Partial duplication of thumb phalanx (HP:0009944)3.94835130
18Abnormality of the pancreatic islet cells (HP:0006476)3.90776316
19Abnormality of endocrine pancreas physiology (HP:0012093)3.90776316
20Insulin-resistant diabetes mellitus (HP:0000831)3.80222536
21Ketoacidosis (HP:0001993)3.79460501
22Choroideremia (HP:0001139)3.75412039
23Dysautonomia (HP:0002459)3.72615166
24Pheochromocytoma (HP:0002666)3.70924234
25Abnormality of the middle phalanges of the toes (HP:0010183)3.55639686
26Increased CSF protein (HP:0002922)3.55464115
27Stenosis of the external auditory canal (HP:0000402)3.54205635
28Hyperparathyroidism (HP:0000843)3.44458144
29Hypercortisolism (HP:0001578)3.42273640
30Dysostosis multiplex (HP:0000943)3.37018245
31Acanthosis nigricans (HP:0000956)3.36729129
32Abnormality of complement system (HP:0005339)3.33833130
33Partial duplication of the phalanx of hand (HP:0009999)3.31928910
34Orthostatic hypotension (HP:0001278)3.29056364
35Right ventricular cardiomyopathy (HP:0011663)3.23858132
36Neonatal death (HP:0003811)3.22183126
37Xanthomatosis (HP:0000991)3.21013225
38Ulnar bowing (HP:0003031)3.09525641
39Systemic lupus erythematosus (HP:0002725)3.09058713
40Neuroendocrine neoplasm (HP:0100634)3.08746411
41Menstrual irregularities (HP:0000858)3.07270726
42Broad metatarsal (HP:0001783)3.06333329
43Popliteal pterygium (HP:0009756)3.04355697
44Abnormality of the phalanges of the 2nd finger (HP:0009541)2.98574505
45Thickened helices (HP:0000391)2.97095195
46Abnormality of glutamine family amino acid metabolism (HP:0010902)2.96412761
47Retinal atrophy (HP:0001105)2.92465820
48Anteriorly placed anus (HP:0001545)2.84454625
49Hyperphosphatemia (HP:0002905)2.82441525
50Growth hormone excess (HP:0000845)2.81919175
51Coronal craniosynostosis (HP:0004440)2.80378236
52Neonatal short-limb short stature (HP:0008921)2.77332196
53Mucopolysacchariduria (HP:0008155)2.75058843
54Urinary glycosaminoglycan excretion (HP:0003541)2.75058843
55Segmental peripheral demyelination/remyelination (HP:0003481)2.72691387
56Distal lower limb muscle weakness (HP:0009053)2.71028728
57Split foot (HP:0001839)2.69981596
58Scotoma (HP:0000575)2.67052530
59Abnormal hemoglobin (HP:0011902)2.67033934
60Shallow orbits (HP:0000586)2.60655886
61Insulin resistance (HP:0000855)2.55774854
62Mixed hearing impairment (HP:0000410)2.52878770
63Restlessness (HP:0000711)2.50448153
64Cerebral palsy (HP:0100021)2.49898135
65Macroorchidism (HP:0000053)2.48332236
66Abnormality of mucopolysaccharide metabolism (HP:0011020)2.47362232
67Abnormality of polysaccharide metabolism (HP:0011012)2.47362232
68Abnormality of glycosaminoglycan metabolism (HP:0004371)2.47362232
69Hypotension (HP:0002615)2.42323418
70Conical tooth (HP:0000698)2.42059617
71Ventricular fibrillation (HP:0001663)2.41211090
72Ulnar claw (HP:0001178)2.40124683
73Decreased electroretinogram (ERG) amplitude (HP:0000654)2.34044166
74Alacrima (HP:0000522)2.32398395
75Anomalous pulmonary venous return (HP:0010772)2.32000600
76Gout (HP:0001997)2.31952334
77Hydroxyprolinuria (HP:0003080)2.31447325
78Abnormality of proline metabolism (HP:0010907)2.31447325
79Congenital malformation of the right heart (HP:0011723)2.27074402
80Double outlet right ventricle (HP:0001719)2.27074402
81Visceral angiomatosis (HP:0100761)2.25538615
82Aplasia of the musculature (HP:0100854)2.24698661
83Hemiparesis (HP:0001269)2.24169659
84Abnormality of aromatic amino acid family metabolism (HP:0004338)2.21984242
85Hypoventilation (HP:0002791)2.21046207
86Abnormal autonomic nervous system physiology (HP:0012332)2.21042734
87Flat capital femoral epiphysis (HP:0003370)2.18071522
88Abnormality of incisor morphology (HP:0011063)2.17032300
89Neurofibrillary tangles (HP:0002185)2.16679213
90Enlarged kidneys (HP:0000105)2.16015578
91Abnormality of the dental root (HP:0006486)2.15951395
92Taurodontia (HP:0000679)2.15951395
93Abnormality of permanent molar morphology (HP:0011071)2.15951395
94Abnormality of the vitreous humor (HP:0004327)2.14734891
95Enlarged penis (HP:0000040)2.14280776
96Long toe (HP:0010511)2.14072002
97Abnormal pancreas size (HP:0012094)2.12986539
98Abnormality of glycosphingolipid metabolism (HP:0004343)2.12632907
99Abnormality of glycolipid metabolism (HP:0010969)2.12632907
100Abnormality of liposaccharide metabolism (HP:0010968)2.12632907
101Cupped ear (HP:0000378)2.12609960
102Hand muscle atrophy (HP:0009130)2.12151386
103Abnormal glucose tolerance (HP:0001952)2.11964709
104Asymmetry of the thorax (HP:0001555)2.11162492
105Protuberant abdomen (HP:0001538)2.11100099
106Hypokalemia (HP:0002900)2.10940602
107Ketosis (HP:0001946)2.09556212
108Turricephaly (HP:0000262)2.08680886
109Esophageal varix (HP:0002040)2.07543979
110Abnormality of molar (HP:0011077)2.06860720
111Abnormality of molar morphology (HP:0011070)2.06860720
112Oligomenorrhea (HP:0000876)2.06448787
113Hemangiomatosis (HP:0007461)2.06296907
114Arterial tortuosity (HP:0005116)2.05724745
115Bell-shaped thorax (HP:0001591)2.05473128
116Abnormality of the aortic arch (HP:0012303)2.04941786
117Unilateral renal agenesis (HP:0000122)2.02441470
118Protrusio acetabuli (HP:0003179)2.00012553
119Adrenal overactivity (HP:0002717)1.99753387
120Abnormality of the intrinsic pathway (HP:0010989)1.99497833
121Abnormality of monocarboxylic acid metabolism (HP:0010996)1.99281555
122Hypobetalipoproteinemia (HP:0003563)1.99155469
123Abnormality of the dental pulp (HP:0006479)1.98544485
124Skin nodule (HP:0200036)1.97803024
125Broad distal phalanx of finger (HP:0009836)1.97643279
126Synostosis involving the elbow (HP:0003938)1.97586130
127Humeroradial synostosis (HP:0003041)1.97586130
128Thoracolumbar scoliosis (HP:0002944)1.96794201
129Abnormality of the distal phalanges of the toes (HP:0010182)1.96179087
130Abnormality of the pulmonary veins (HP:0011718)1.96093315
131Vacuolated lymphocytes (HP:0001922)1.96013613
132Myoglobinuria (HP:0002913)1.94863052
133Limited elbow extension (HP:0001377)1.94596945
134Epiphyseal dysplasia (HP:0002656)1.93945334
135Supranuclear gaze palsy (HP:0000605)1.93672361
136Striae distensae (HP:0001065)1.93426409
137Metaphyseal irregularity (HP:0003025)1.93129788
138Hemorrhage of the eye (HP:0011885)1.91058481
139Postural tremor (HP:0002174)1.90815487
140Deep venous thrombosis (HP:0002625)1.90512484
141Mitral stenosis (HP:0001718)1.90396239
142Abnormality of the 2nd finger (HP:0004100)1.90120613
143Hypophosphatemia (HP:0002148)1.90010134
144Hypsarrhythmia (HP:0002521)1.89774573
145Abnormality of the distal phalanx of the thumb (HP:0009617)1.89468694
146Vascular tortuosity (HP:0004948)1.88312701
147Abnormality of potassium homeostasis (HP:0011042)1.88017850
148Progressive neurologic deterioration (HP:0002344)1.87803158
149Ventricular tachycardia (HP:0004756)1.87639963
150Widely patent fontanelles and sutures (HP:0004492)1.87614108
151EEG with generalized epileptiform discharges (HP:0011198)1.86953845
152Flat acetabular roof (HP:0003180)1.86506951
153Abnormality of carpal bone ossification (HP:0006257)1.86470246
154Exocrine pancreatic insufficiency (HP:0001738)1.86327867
155Prominent metopic ridge (HP:0005487)1.84486083
156Rhizomelia (HP:0008905)1.82717264
157Abnormality of the parietal bone (HP:0002696)1.82601338
158Papilledema (HP:0001085)1.82104153
159Neoplasm of the heart (HP:0100544)1.82073363
160Glomerulonephritis (HP:0000099)1.81562340
161Patent foramen ovale (HP:0001655)1.81378863
162Increased circulating renin level (HP:0000848)1.81292890
163Choanal stenosis (HP:0000452)1.81202330
164Abdominal distention (HP:0003270)1.80993419
165Hypoplasia of dental enamel (HP:0006297)1.79745842
166Sleep apnea (HP:0010535)1.79592758
167Beaking of vertebral bodies (HP:0004568)1.79104043
168Labial hypoplasia (HP:0000066)1.78030122
169Limited hip movement (HP:0008800)1.77144100
170Glycosuria (HP:0003076)1.75351256
171Abnormality of urine glucose concentration (HP:0011016)1.75351256
172Type II lissencephaly (HP:0007260)1.75269629
173Hyperkalemia (HP:0002153)1.75160056
174Epileptiform EEG discharges (HP:0011182)1.74624677
175Megalencephaly (HP:0001355)1.73891535
176Premature skin wrinkling (HP:0100678)1.73036769
177Decreased circulating renin level (HP:0003351)1.72063027
178Cerebral inclusion bodies (HP:0100314)1.70985256
179Distal upper limb amyotrophy (HP:0007149)1.70759548
180Upper limb amyotrophy (HP:0009129)1.70759548
181Abnormal vertebral ossification (HP:0100569)1.69411268
182Complement deficiency (HP:0004431)1.65266791
183Prolonged QT interval (HP:0001657)1.64893783
184Hypothermia (HP:0002045)1.64257037
185Hyperphosphaturia (HP:0003109)1.64229339
186Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.61827482
187Cardiomegaly (HP:0001640)1.61255922
188Conjugated hyperbilirubinemia (HP:0002908)1.60697523
189Bronchomalacia (HP:0002780)1.60304769
190Palpitations (HP:0001962)1.60033835
191Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.58276518
192Blue irides (HP:0000635)1.57995049

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK159.29470458
2FGFR25.30703124
3WNK34.52944872
4WNK43.62828327
5PIK3CG3.55973163
6PRKD33.51722149
7PRPF4B3.43138030
8INSRR3.24561030
9UHMK12.56206846
10DMPK2.26329000
11MAP3K22.21729053
12ERN12.04414035
13FRK2.02304518
14NTRK11.91546622
15MUSK1.91076517
16TAOK21.90150869
17LMTK21.82931266
18MYLK1.69663245
19GRK11.62043478
20KSR21.61793563
21PAK31.59007765
22MAP3K101.55646464
23TRIB31.51912118
24WNK11.51783366
25TTN1.51594999
26PASK1.50815273
27FGFR31.49898268
28TAOK31.48838883
29RIPK11.47537604
30HIPK21.45810909
31FGFR11.43206675
32LATS11.41667305
33PKN21.39494747
34MAP3K11.38243096
35EPHA31.28934911
36CAMKK21.19695717
37PTK21.17292621
38LATS21.16395711
39MAPKAPK31.15790225
40SCYL21.15290473
41STK38L1.13417308
42PDGFRA1.11893569
43MAP3K121.11738523
44PRKG21.10275169
45ICK1.07266739
46FER1.02436787
47CSK1.02171922
48DYRK1B0.99249280
49IRAK10.98435826
50PRKCH0.94926846
51MAP2K20.91633482
52MAP3K70.88848701
53FLT30.88794111
54IRAK30.84955513
55PRKD20.84604357
56MAP3K90.81949150
57ERBB20.80747178
58MAP3K110.80424054
59BRSK20.80423809
60ROCK10.78598608
61MET0.77857467
62NEK90.77526938
63PTK60.76977740
64ILK0.76801748
65LIMK10.76738971
66PHKG20.76394055
67PHKG10.76394055
68TGFBR20.76077314
69CDC42BPA0.72440814
70SIK10.71852647
71TESK10.71660051
72ARAF0.70315371
73NME10.68199555
74PIK3CA0.64860607
75NTRK30.63998535
76MAP2K10.63134007
77ACVR1B0.61850294
78LRRK20.60781295
79MAPK70.60762340
80CAMK40.60738398
81FGFR40.59374505
82RET0.58395547
83PAK40.56013768
84RPS6KL10.55211899
85RPS6KC10.55211899
86TNIK0.53171534
87DDR20.52995911
88PAK60.50704362
89BRAF0.49594440
90EPHB10.49474931
91DAPK30.48711586
92IRAK20.48065984
93SMG10.47808757
94OXSR10.47581670
95MST1R0.47484934
96JAK20.43164838
97GRK70.41849215
98MAPK30.41614394
99PRKAA10.41184242
100RPS6KA60.40628100
101PDK20.40270539
102MOS0.40162448
103PINK10.40122309
104PAK20.39992587
105MARK20.39962620
106MAPK40.39385766
107ADRBK10.39101750
108ROCK20.37764314
109CAMK1D0.37381038
110STK240.36758833
111PRKD10.36563703
112CAMKK10.35205684
113SGK2230.34996290
114SGK4940.34996290
115MAPK10.34665515
116MAP3K50.34628993
117OBSCN0.34404937
118GRK50.33692272
119GSK3A0.32989396
120MAP3K30.32741820
121CAMK2D0.32313614
122NLK0.31533628
123BCKDK0.31443830
124MATK0.31162335
125MARK30.30680400
126TYK20.30131474
127PDPK10.29690725
128PRKACG0.29667220
129CDK50.28834916
130PRKCE0.28705307
131SRC0.27212174
132STK110.26960999
133IGF1R0.26900324
134SGK30.26330227
135PRKACA0.25836870
136PDGFRB0.25257321
137RPS6KA20.24540425
138CDK120.24486248
139PDK40.22073375
140PDK30.22073375
141PRKAA20.21801781
142MTOR0.20500333
143EPHA20.20461848
144EPHB20.20409652
145STK390.20339532
146JAK10.19614409
147BRSK10.19286288
148MAP3K130.17685674
149PRKCI0.17670966
150STK380.17103864
151TAOK10.16801484

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.21965613
2Protein export_Homo sapiens_hsa030603.98333745
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.98258616
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.92579248
5Insulin secretion_Homo sapiens_hsa049113.35909477
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.35199668
7Vitamin digestion and absorption_Homo sapiens_hsa049773.22891834
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.64229306
9Histidine metabolism_Homo sapiens_hsa003402.57686332
10Complement and coagulation cascades_Homo sapiens_hsa046102.52554319
11Type II diabetes mellitus_Homo sapiens_hsa049302.02111572
12Vibrio cholerae infection_Homo sapiens_hsa051101.99362635
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.96780161
14Type I diabetes mellitus_Homo sapiens_hsa049401.94757206
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.93190852
16Retinol metabolism_Homo sapiens_hsa008301.90774403
17Sulfur metabolism_Homo sapiens_hsa009201.81158033
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.80261650
19Lysosome_Homo sapiens_hsa041421.78692097
20Prion diseases_Homo sapiens_hsa050201.76434740
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.58437540
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.53695479
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.52645924
24Protein digestion and absorption_Homo sapiens_hsa049741.50269300
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.48044966
26Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.40499731
27Glucagon signaling pathway_Homo sapiens_hsa049221.40388724
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.39796506
29Other glycan degradation_Homo sapiens_hsa005111.38913039
30Tight junction_Homo sapiens_hsa045301.38472056
31Chemical carcinogenesis_Homo sapiens_hsa052041.36427357
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36240589
33N-Glycan biosynthesis_Homo sapiens_hsa005101.35095114
34Thyroid hormone synthesis_Homo sapiens_hsa049181.32934071
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.32207641
36Ovarian steroidogenesis_Homo sapiens_hsa049131.27453333
37Mineral absorption_Homo sapiens_hsa049781.26574851
38Arginine biosynthesis_Homo sapiens_hsa002201.23945708
39Cocaine addiction_Homo sapiens_hsa050301.21792113
40Regulation of autophagy_Homo sapiens_hsa041401.21451637
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21084877
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20740630
43Carbohydrate digestion and absorption_Homo sapiens_hsa049731.17676297
44Arginine and proline metabolism_Homo sapiens_hsa003301.16507907
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14472513
46Pancreatic secretion_Homo sapiens_hsa049721.05924111
47Nitrogen metabolism_Homo sapiens_hsa009101.03264861
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03028719
49PPAR signaling pathway_Homo sapiens_hsa033200.98855277
50Dorso-ventral axis formation_Homo sapiens_hsa043200.98766601
51Aldosterone synthesis and secretion_Homo sapiens_hsa049250.98061391
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97405106
53Circadian rhythm_Homo sapiens_hsa047100.96049983
54Fat digestion and absorption_Homo sapiens_hsa049750.93724048
55ABC transporters_Homo sapiens_hsa020100.93570817
56Linoleic acid metabolism_Homo sapiens_hsa005910.91191206
57Folate biosynthesis_Homo sapiens_hsa007900.90899463
58Renin secretion_Homo sapiens_hsa049240.90285288
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.89837743
60Insulin signaling pathway_Homo sapiens_hsa049100.88118323
61Amphetamine addiction_Homo sapiens_hsa050310.87073431
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.85805564
63Circadian entrainment_Homo sapiens_hsa047130.84671338
64Synaptic vesicle cycle_Homo sapiens_hsa047210.83327501
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83273370
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82180993
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81260110
68Insulin resistance_Homo sapiens_hsa049310.80089039
69Caffeine metabolism_Homo sapiens_hsa002320.78641502
70Fatty acid metabolism_Homo sapiens_hsa012120.77646975
71Dopaminergic synapse_Homo sapiens_hsa047280.77627060
72Hepatitis C_Homo sapiens_hsa051600.76146371
73Estrogen signaling pathway_Homo sapiens_hsa049150.75239358
74Sphingolipid metabolism_Homo sapiens_hsa006000.71559099
75Fatty acid degradation_Homo sapiens_hsa000710.70837808
76Thyroid cancer_Homo sapiens_hsa052160.69889129
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69374435
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68439515
79Renin-angiotensin system_Homo sapiens_hsa046140.67323131
80Gastric acid secretion_Homo sapiens_hsa049710.64331835
81Adherens junction_Homo sapiens_hsa045200.62972270
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62755535
83Cholinergic synapse_Homo sapiens_hsa047250.62284376
84Tryptophan metabolism_Homo sapiens_hsa003800.61623357
85Focal adhesion_Homo sapiens_hsa045100.61543574
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61454323
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59470880
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59453572
89GABAergic synapse_Homo sapiens_hsa047270.59403029
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.59008329
91Fructose and mannose metabolism_Homo sapiens_hsa000510.58997988
92Dilated cardiomyopathy_Homo sapiens_hsa054140.58920571
93Alzheimers disease_Homo sapiens_hsa050100.57085069
94Melanogenesis_Homo sapiens_hsa049160.55345958
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.55269187
96Sulfur relay system_Homo sapiens_hsa041220.55172994
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55163106
98AMPK signaling pathway_Homo sapiens_hsa041520.54297417
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53820087
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53730655
101Starch and sucrose metabolism_Homo sapiens_hsa005000.53585475
102cAMP signaling pathway_Homo sapiens_hsa040240.53458434
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53303074
104TGF-beta signaling pathway_Homo sapiens_hsa043500.52835404
105Oxidative phosphorylation_Homo sapiens_hsa001900.52803150
106Glycerolipid metabolism_Homo sapiens_hsa005610.52512315
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.51831430
108Taste transduction_Homo sapiens_hsa047420.51421345
109Primary bile acid biosynthesis_Homo sapiens_hsa001200.51207994
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50797646
111Butanoate metabolism_Homo sapiens_hsa006500.50554305
112Serotonergic synapse_Homo sapiens_hsa047260.50430211
113Salivary secretion_Homo sapiens_hsa049700.50362934
114Galactose metabolism_Homo sapiens_hsa000520.50279807
115Phototransduction_Homo sapiens_hsa047440.50066075
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49021215
117Ether lipid metabolism_Homo sapiens_hsa005650.45790149
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44639311
119Long-term depression_Homo sapiens_hsa047300.44410473
120Prolactin signaling pathway_Homo sapiens_hsa049170.43885975
121Steroid biosynthesis_Homo sapiens_hsa001000.43289828
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43029810
123Arachidonic acid metabolism_Homo sapiens_hsa005900.42624920
124Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42449149
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41202992
126ECM-receptor interaction_Homo sapiens_hsa045120.41191748
127Bile secretion_Homo sapiens_hsa049760.40899857
128Gap junction_Homo sapiens_hsa045400.40247667
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.40215466
130Tyrosine metabolism_Homo sapiens_hsa003500.38985451
131Long-term potentiation_Homo sapiens_hsa047200.38185378
132Staphylococcus aureus infection_Homo sapiens_hsa051500.37737939
133Choline metabolism in cancer_Homo sapiens_hsa052310.37262998
134Amoebiasis_Homo sapiens_hsa051460.36623532
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35989054
136Pertussis_Homo sapiens_hsa051330.35921478
137Phenylalanine metabolism_Homo sapiens_hsa003600.35824641
138Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35101961
139Propanoate metabolism_Homo sapiens_hsa006400.34098055
140Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34013179
141Cardiac muscle contraction_Homo sapiens_hsa042600.33726357
142beta-Alanine metabolism_Homo sapiens_hsa004100.33589253
143Pyruvate metabolism_Homo sapiens_hsa006200.33253986
144Parkinsons disease_Homo sapiens_hsa050120.33106026
145Proteoglycans in cancer_Homo sapiens_hsa052050.32248547
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29585031
147Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29316575
148Glutathione metabolism_Homo sapiens_hsa004800.29157732
149Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25343301
150Bladder cancer_Homo sapiens_hsa052190.25112047

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