SFSWAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a human homolog of Drosophila splicing regulatory protein. This gene autoregulates its expression by control of splicing of its first two introns. In addition, it also regulates the splicing of fibronectin and CD45 genes. Two transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of histone H3-K27 methylation (GO:0061085)5.34362159
2histone H3-K4 trimethylation (GO:0080182)4.35873557
3histone H3-K9 demethylation (GO:0033169)4.15266179
4negative regulation of erythrocyte differentiation (GO:0045647)4.04450538
5nuclear pore complex assembly (GO:0051292)3.82487230
6negative regulation of cAMP-mediated signaling (GO:0043951)3.75621894
7histone lysine demethylation (GO:0070076)3.70231736
8negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.63220135
9histone demethylation (GO:0016577)3.60103552
10pre-miRNA processing (GO:0031054)3.59659387
11establishment of nucleus localization (GO:0040023)3.58068271
12regulation of histone methylation (GO:0031060)3.56201895
13* mRNA splice site selection (GO:0006376)3.53932157
14locomotory exploration behavior (GO:0035641)3.53195717
15positive regulation of gene expression, epigenetic (GO:0045815)3.49528655
16positive regulation by host of viral transcription (GO:0043923)3.41245333
17regulation of histone H3-K4 methylation (GO:0051569)3.40363496
18histone deubiquitination (GO:0016578)3.36428933
19dosage compensation (GO:0007549)3.32824861
20positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.32269667
21positive regulation of CREB transcription factor activity (GO:0032793)3.31800039
22dendrite morphogenesis (GO:0048813)3.31366959
23peptidyl-lysine trimethylation (GO:0018023)3.30971735
24histone H4 deacetylation (GO:0070933)3.27814658
25histone H3-K4 methylation (GO:0051568)3.24394575
26negative regulation of translation, ncRNA-mediated (GO:0040033)3.23081484
27regulation of translation, ncRNA-mediated (GO:0045974)3.23081484
28negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.23081484
29monoubiquitinated protein deubiquitination (GO:0035520)3.22326439
30cerebellar Purkinje cell differentiation (GO:0021702)3.18511983
31protein demethylation (GO:0006482)3.17798202
32protein dealkylation (GO:0008214)3.17798202
33regulation of chromatin binding (GO:0035561)3.14988183
34positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.13942880
35layer formation in cerebral cortex (GO:0021819)3.09278853
36ionotropic glutamate receptor signaling pathway (GO:0035235)3.09189578
37mannose metabolic process (GO:0006013)3.06581768
38insulin-like growth factor receptor signaling pathway (GO:0048009)3.05540045
39histone H3 deacetylation (GO:0070932)3.03396413
40negative regulation of gene expression, epigenetic (GO:0045814)3.01449634
41positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.00527805
42positive regulation of gamma-delta T cell activation (GO:0046645)2.98242449
43dendritic spine morphogenesis (GO:0060997)2.96508462
44* negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.96132172
45nuclear pore organization (GO:0006999)2.93846199
46snRNA transcription (GO:0009301)2.93206009
47histone H3-K9 methylation (GO:0051567)2.93145758
48positive regulation of granulocyte differentiation (GO:0030854)2.92570222
49thymic T cell selection (GO:0045061)2.92558125
50regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.90699062
51protein-DNA complex disassembly (GO:0032986)2.90210222
52nucleosome disassembly (GO:0006337)2.90210222
53regulation of gamma-delta T cell differentiation (GO:0045586)2.89635946
54negative regulation of histone modification (GO:0031057)2.89485903
55histone lysine methylation (GO:0034968)2.89407756
56glutamate receptor signaling pathway (GO:0007215)2.87780547
57positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.86669790
58regulation of ARF protein signal transduction (GO:0032012)2.86271216
59chromatin silencing (GO:0006342)2.84839536
60modulation by virus of host process (GO:0019054)2.84018237
61cell migration in hindbrain (GO:0021535)2.81624232
62heterochromatin organization (GO:0070828)2.81579534
63axonal fasciculation (GO:0007413)2.81362298
64cytoplasmic mRNA processing body assembly (GO:0033962)2.80103023
65regulation of glutamate receptor signaling pathway (GO:1900449)2.78193675
66spliceosomal tri-snRNP complex assembly (GO:0000244)2.77656514
67negative T cell selection (GO:0043383)2.76585790
68positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.75818486
69interkinetic nuclear migration (GO:0022027)2.75602575
70positive thymic T cell selection (GO:0045059)2.75527558
71positive regulation of protein deacetylation (GO:0090312)2.75492616
72histone H3-K36 demethylation (GO:0070544)2.75034617
73central nervous system projection neuron axonogenesis (GO:0021952)2.74461036
74positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.74241728
75mitotic sister chromatid cohesion (GO:0007064)2.71997358
76regulation of gamma-delta T cell activation (GO:0046643)2.71721331
77cytoskeletal anchoring at plasma membrane (GO:0007016)2.71098587
78histone acetylation (GO:0016573)2.70531722
79regulation of granulocyte differentiation (GO:0030852)2.69283207
80coronary vasculature morphogenesis (GO:0060977)2.68506923
81positive regulation of synapse maturation (GO:0090129)2.67345162
82pore complex assembly (GO:0046931)2.67068363
83negative thymic T cell selection (GO:0045060)2.66787057
84regulation of short-term neuronal synaptic plasticity (GO:0048172)2.66413022
85mitotic chromosome condensation (GO:0007076)2.66190778
86peptidyl-lysine methylation (GO:0018022)2.66030596
87nucleus localization (GO:0051647)2.65709486
88poly(A)+ mRNA export from nucleus (GO:0016973)2.65252329
89stress granule assembly (GO:0034063)2.64380794
90DNA alkylation (GO:0006305)2.64263052
91DNA methylation (GO:0006306)2.64263052
92T cell selection (GO:0045058)2.62485967
93negative regulation of chromatin modification (GO:1903309)2.62365192
94neuronal stem cell maintenance (GO:0097150)2.61966316
95vocalization behavior (GO:0071625)2.61341316
96histone H3-K9 modification (GO:0061647)2.61316283
97response to muramyl dipeptide (GO:0032495)2.58833914
98internal peptidyl-lysine acetylation (GO:0018393)2.57866520
99regulation of ARF GTPase activity (GO:0032312)2.57226606
100ribosomal small subunit biogenesis (GO:0042274)2.57073009
101G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.56806106
102glucocorticoid receptor signaling pathway (GO:0042921)2.56497825
103histone H4 acetylation (GO:0043967)2.54910374
104negative regulation of myotube differentiation (GO:0010832)2.53954176
105negative regulation of DNA-templated transcription, elongation (GO:0032785)2.53667945
106negative regulation of granulocyte differentiation (GO:0030853)2.53297131
107N-terminal protein amino acid acetylation (GO:0006474)2.52581768
108peptidyl-lysine dimethylation (GO:0018027)2.51636192
109negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.51422530
110negative regulation of cell killing (GO:0031342)2.51422530
111neuron recognition (GO:0008038)2.51157791
112peptidyl-lysine acetylation (GO:0018394)2.50411916
113positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.50030158
114positive regulation of Rap GTPase activity (GO:0032854)2.49948507
115NLS-bearing protein import into nucleus (GO:0006607)2.49754541
116DNA duplex unwinding (GO:0032508)2.49154763
117histone H3 acetylation (GO:0043966)2.47128518
118histone deacetylation (GO:0016575)2.46983366
119histone methylation (GO:0016571)2.44785293
120head development (GO:0060322)2.41319179
121synaptic transmission, glutamatergic (GO:0035249)2.39546049
122hippo signaling (GO:0035329)2.37829936
123positive regulation of dendritic spine morphogenesis (GO:0061003)2.37197425
124long-term memory (GO:0007616)2.36874457
125membrane depolarization during action potential (GO:0086010)2.34817028
126glial cell proliferation (GO:0014009)2.34791647
127regulation of NFAT protein import into nucleus (GO:0051532)2.34137525
128heart morphogenesis (GO:0003007)2.33322556
129positive regulation of histone deacetylation (GO:0031065)2.32794135
130exploration behavior (GO:0035640)2.29827351
131establishment of mitotic spindle orientation (GO:0000132)2.28649197
132cell differentiation in hindbrain (GO:0021533)2.28455887
133positive regulation of RNA splicing (GO:0033120)2.27883200
134histone H4-K16 acetylation (GO:0043984)2.26926986
135positive regulation of fibroblast migration (GO:0010763)2.26327956
136protein localization to synapse (GO:0035418)2.22988001
137negative regulation of histone methylation (GO:0031061)2.21942167
138regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.21928969
139G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.21226996
140regulation of RNA export from nucleus (GO:0046831)2.20262255
141regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.20159035
142synaptic vesicle maturation (GO:0016188)2.19622439
143intracellular estrogen receptor signaling pathway (GO:0030520)2.19197095
144neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.18848423
145planar cell polarity pathway involved in neural tube closure (GO:0090179)2.17387074
146establishment of protein localization to Golgi (GO:0072600)2.16207325
147positive T cell selection (GO:0043368)2.16124957
148synaptic vesicle endocytosis (GO:0048488)2.15984385
149establishment of mitotic spindle localization (GO:0040001)2.15964118
150positive regulation of dendrite morphogenesis (GO:0050775)2.15934107
151regulation of axon extension involved in axon guidance (GO:0048841)2.13770777
152neural tube development (GO:0021915)2.13389462
153postsynaptic membrane organization (GO:0001941)2.12683842
154cerebellar granule cell differentiation (GO:0021707)2.12616406
155regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.11878410
156sodium ion export (GO:0071436)2.11440105
157regulation of synapse maturation (GO:0090128)2.11342904
158central nervous system neuron axonogenesis (GO:0021955)2.10569600
159regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.10172856
160regulation of dendritic spine morphogenesis (GO:0061001)2.09629251
161peptidyl-threonine phosphorylation (GO:0018107)2.09403067
162transmission of nerve impulse (GO:0019226)2.09277214
163regulation of nucleobase-containing compound transport (GO:0032239)2.09064748
164membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.08440771
165dendritic spine organization (GO:0097061)2.07589774
166cellular potassium ion homeostasis (GO:0030007)2.07477359
167corticosteroid receptor signaling pathway (GO:0031958)2.07131471
168neuronal ion channel clustering (GO:0045161)2.06935128
169neuromuscular process controlling balance (GO:0050885)2.06325223
170nerve growth factor signaling pathway (GO:0038180)2.05636609
171establishment of spindle localization (GO:0051293)2.05360514
172neuron cell-cell adhesion (GO:0007158)2.01190897

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.77690800
2E2F7_22180533_ChIP-Seq_HELA_Human3.93050972
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.02349204
4* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.89007742
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.80023069
6DROSHA_22980978_ChIP-Seq_HELA_Human2.50817876
7TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.41400270
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.18490398
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.10138679
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.08833522
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.06099191
12MAF_26560356_Chip-Seq_TH2_Human2.03668672
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.01255328
14CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.00797814
15LXR_22292898_ChIP-Seq_THP-1_Human1.98904684
16ELK3_25401928_ChIP-Seq_HUVEC_Human1.98681543
17SCL_19346495_ChIP-Seq_HPC-7_Human1.98099686
18RARB_27405468_Chip-Seq_BRAIN_Mouse1.96886617
19KDM2B_26808549_Chip-Seq_SUP-B15_Human1.96376526
20SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.96217647
21MAF_26560356_Chip-Seq_TH1_Human1.95942098
22IKZF1_21737484_ChIP-ChIP_HCT116_Human1.95871336
23KDM2B_26808549_Chip-Seq_DND41_Human1.94620427
24WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.94500312
25ZFP281_27345836_Chip-Seq_ESCs_Mouse1.94426724
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.91704146
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.91704146
28DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.86105985
29KDM2B_26808549_Chip-Seq_K562_Human1.85991586
30TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.85213461
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.83882366
32TP53_16413492_ChIP-PET_HCT116_Human1.82484151
33KDM2B_26808549_Chip-Seq_JURKAT_Human1.80459672
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.78594479
35EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.78262545
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.77041647
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.75275350
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74055501
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.72886855
40MYC_22102868_ChIP-Seq_BL_Human1.72886117
41SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.70838156
42NCOR1_26117541_ChIP-Seq_K562_Human1.70683097
43UTX_26944678_Chip-Seq_JUKART_Human1.69595925
44GBX2_23144817_ChIP-Seq_PC3_Human1.68685658
45P68_20966046_ChIP-Seq_HELA_Human1.68330643
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.67673197
47AR_21572438_ChIP-Seq_LNCaP_Human1.64818533
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.61884801
49VDR_24763502_ChIP-Seq_THP-1_Human1.60906526
50CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.60517109
51TCF7_22412390_ChIP-Seq_EML_Mouse1.60381366
52SMC4_20622854_ChIP-Seq_HELA_Human1.60259484
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57771455
54CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.56797806
55ZFP281_18757296_ChIP-ChIP_E14_Mouse1.56540511
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55811871
57MTF2_20144788_ChIP-Seq_MESCs_Mouse1.55611244
58SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.53145610
59STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.53006980
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.52332390
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51344996
62FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.51201117
63RACK7_27058665_Chip-Seq_MCF-7_Human1.50267377
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.46813446
65EED_16625203_ChIP-ChIP_MESCs_Mouse1.45628677
66SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43894118
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.43051585
68KDM5A_27292631_Chip-Seq_BREAST_Human1.43021699
69* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.41962650
70RING1B_27294783_Chip-Seq_NPCs_Mouse1.41869904
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39789643
72SUZ12_27294783_Chip-Seq_ESCs_Mouse1.39682294
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39309573
74SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.38300138
75CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37313560
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37180941
77RUNX1_27514584_Chip-Seq_MCF-7_Human1.37052943
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.34153242
79ISL1_27105846_Chip-Seq_CPCs_Mouse1.34039514
80SA1_27219007_Chip-Seq_ERYTHROID_Human1.33983616
81REST_21632747_ChIP-Seq_MESCs_Mouse1.31155258
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30726571
83FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.30071605
84HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.29394589
85TP63_19390658_ChIP-ChIP_HaCaT_Human1.29353960
86AR_19668381_ChIP-Seq_PC3_Human1.29143080
87TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.27818608
88MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.27660742
89CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27469866
90RING1B_27294783_Chip-Seq_ESCs_Mouse1.27246155
91SALL1_21062744_ChIP-ChIP_HESCs_Human1.26704624
92RUNX1_22412390_ChIP-Seq_EML_Mouse1.25628566
93AHR_22903824_ChIP-Seq_MCF-7_Human1.25152544
94ARNT_22903824_ChIP-Seq_MCF-7_Human1.24815735
95EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24368996
96YAP1_20516196_ChIP-Seq_MESCs_Mouse1.23577903
97GATA1_19941827_ChIP-Seq_MEL_Mouse1.22580759
98MYB_26560356_Chip-Seq_TH1_Human1.21266934
99TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20958241
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20393446
101CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19866097
102GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19720573
103HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.19512184
104ELF1_20517297_ChIP-Seq_JURKAT_Human1.18811270
105STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18542115
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16193705
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16193705
108OCT4_19829295_ChIP-Seq_ESCs_Human1.15756917
109ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14559392
110E2F1_21310950_ChIP-Seq_MCF-7_Human1.13112439
111RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12569531
112RUNX_20019798_ChIP-Seq_JUKART_Human1.12396746
113SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.11492616
114PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10865587
115RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10821759
116CTCF_27219007_Chip-Seq_Bcells_Human1.10430424
117CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09863150
118ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09032051
119STAT3_23295773_ChIP-Seq_U87_Human1.08974155
120CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08731876
121KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.08520294
122VDR_21846776_ChIP-Seq_THP-1_Human1.06822312
123NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06586059
124BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05433301
125PKCTHETA_26484144_Chip-Seq_BREAST_Human1.05066306
126DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04826854
127UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04499902
128SPI1_23127762_ChIP-Seq_K562_Human1.04207889
129OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.03648743
130CTCF_21964334_ChIP-Seq_BJAB-B_Human1.03648574
131P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03553108
132* CIITA_25753668_ChIP-Seq_RAJI_Human1.02593254
133TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01694644
134TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01034066
135TP53_22127205_ChIP-Seq_IMR90_Human1.00662532
136KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99598410
137MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.99377768
138ZNF274_21170338_ChIP-Seq_K562_Hela0.98481036
139TET1_21451524_ChIP-Seq_MESCs_Mouse0.98194046
140BCOR_27268052_Chip-Seq_Bcells_Human0.98131104
141SOX2_21211035_ChIP-Seq_LN229_Gbm0.98088914
142* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97896528
143ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95779172
144PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95536445
145PHF8_20622854_ChIP-Seq_HELA_Human0.95506485
146TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94860344
147SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94622126
148SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.94619887
149POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94352421
150TCF4_23295773_ChIP-Seq_U87_Human0.94169856
151CHD1_26751641_Chip-Seq_LNCaP_Human0.94129198
152CREB1_26743006_Chip-Seq_LNCaP_Human0.93726515
153SMAD3_21741376_ChIP-Seq_ESCs_Human0.93494449
154SMAD4_21799915_ChIP-Seq_A2780_Human0.93244395
155ERG_21242973_ChIP-ChIP_JURKAT_Human0.92638600
156PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91800292
157CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91595812
158TCF4_18268006_ChIP-ChIP_LS174T_Human0.90768679
159MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.88833857

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.40956656
2MP0008057_abnormal_DNA_replication4.10623900
3MP0000569_abnormal_digit_pigmentation3.62019144
4MP0003787_abnormal_imprinting3.41680458
5MP0004185_abnormal_adipocyte_glucose3.17940470
6MP0003763_abnormal_thymus_physiology3.08067531
7MP0004381_abnormal_hair_follicle2.69725714
8MP0002396_abnormal_hematopoietic_system2.51553141
9MP0003635_abnormal_synaptic_transmissio2.35464572
10MP0002009_preneoplasia2.28230686
11MP0003172_abnormal_lysosome_physiology2.15978864
12MP0004808_abnormal_hematopoietic_stem2.01805760
13MP0005076_abnormal_cell_differentiation2.01657009
14MP0005666_abnormal_adipose_tissue1.98733490
15MP0005423_abnormal_somatic_nervous1.94339984
16MP0000703_abnormal_thymus_morphology1.91096889
17MP0008995_early_reproductive_senescence1.90467750
18MP0003121_genomic_imprinting1.89682208
19MP0004270_analgesia1.84810110
20MP0000778_abnormal_nervous_system1.84476562
21MP0006292_abnormal_olfactory_placode1.76842244
22MP0003123_paternal_imprinting1.74630408
23MP0003077_abnormal_cell_cycle1.74356198
24MP0003880_abnormal_central_pattern1.68356590
25MP0002089_abnormal_postnatal_growth/wei1.67545748
26MP0005375_adipose_tissue_phenotype1.67155862
27MP0001348_abnormal_lacrimal_gland1.62508119
28MP0002063_abnormal_learning/memory/cond1.57202203
29MP0009745_abnormal_behavioral_response1.56724859
30MP0005058_abnormal_lysosome_morphology1.55062413
31MP0003119_abnormal_digestive_system1.53527805
32MP0005623_abnormal_meninges_morphology1.52480366
33MP0000733_abnormal_muscle_development1.52277458
34MP0005377_hearing/vestibular/ear_phenot1.49487136
35MP0003878_abnormal_ear_physiology1.49487136
36MP0003385_abnormal_body_wall1.46856130
37MP0008569_lethality_at_weaning1.45067417
38MP0009278_abnormal_bone_marrow1.45036942
39MP0008961_abnormal_basal_metabolism1.44976260
40MP0003283_abnormal_digestive_organ1.43995209
41MP0003122_maternal_imprinting1.43727967
42MP0002398_abnormal_bone_marrow1.37939843
43MP0003861_abnormal_nervous_system1.37568708
44MP0002184_abnormal_innervation1.37507725
45MP0000003_abnormal_adipose_tissue1.36189787
46MP0004145_abnormal_muscle_electrophysio1.35915698
47MP0005409_darkened_coat_color1.35424971
48MP0000350_abnormal_cell_proliferation1.33854319
49MP0000955_abnormal_spinal_cord1.33123181
50MP0010094_abnormal_chromosome_stability1.32427085
51MP0003935_abnormal_craniofacial_develop1.32385831
52MP0000678_abnormal_parathyroid_gland1.32319622
53MP0002572_abnormal_emotion/affect_behav1.31887171
54MP0002064_seizures1.28405353
55MP0009780_abnormal_chondrocyte_physiolo1.27909723
56MP0001188_hyperpigmentation1.25143068
57MP0001873_stomach_inflammation1.24094505
58MP0005397_hematopoietic_system_phenotyp1.23984321
59MP0001545_abnormal_hematopoietic_system1.23984321
60MP0000428_abnormal_craniofacial_morphol1.23935081
61MP0002152_abnormal_brain_morphology1.23273050
62MP0001486_abnormal_startle_reflex1.23247266
63MP0005451_abnormal_body_composition1.22747258
64MP0004130_abnormal_muscle_cell1.20727408
65MP0003045_fibrosis1.18505257
66MP0000462_abnormal_digestive_system1.18497628
67MP0002970_abnormal_white_adipose1.17469704
68MP0009046_muscle_twitch1.16723017
69MP0005174_abnormal_tail_pigmentation1.15461342
70MP0003984_embryonic_growth_retardation1.14587740
71MP0001299_abnormal_eye_distance/1.13809386
72MP0003436_decreased_susceptibility_to1.12673035
73MP0002088_abnormal_embryonic_growth/wei1.10828453
74MP0008260_abnormal_autophagy1.10724394
75MP0009115_abnormal_fat_cell1.08011536
76MP0002882_abnormal_neuron_morphology1.06278784
77MP0001730_embryonic_growth_arrest1.06229289
78MP0004811_abnormal_neuron_physiology1.05519875
79MP0004947_skin_inflammation1.04764901
80MP0005380_embryogenesis_phenotype1.03642138
81MP0001672_abnormal_embryogenesis/_devel1.03642138
82MP0003115_abnormal_respiratory_system1.03116344
83MP0009703_decreased_birth_body1.02707272
84MP0000537_abnormal_urethra_morphology1.02424966
85MP0003111_abnormal_nucleus_morphology1.01933174
86MP0003755_abnormal_palate_morphology1.01660542
87MP0002116_abnormal_craniofacial_bone1.01352980
88MP0002653_abnormal_ependyma_morphology1.00991043
89MP0002084_abnormal_developmental_patter1.00132620
90MP0002272_abnormal_nervous_system1.00037514
91MP0004885_abnormal_endolymph0.99870758
92MP0003941_abnormal_skin_development0.99816175
93MP0002067_abnormal_sensory_capabilities0.99810543
94MP0001502_abnormal_circadian_rhythm0.99529458
95MP0008770_decreased_survivor_rate0.98612500
96MP0001800_abnormal_humoral_immune0.98573909
97MP0002102_abnormal_ear_morphology0.98497883
98MP0004858_abnormal_nervous_system0.98083377
99MP0002925_abnormal_cardiovascular_devel0.97769817
100MP0000432_abnormal_head_morphology0.97726315
101MP0000566_synostosis0.97163161
102MP0004510_myositis0.96693596
103MP0005621_abnormal_cell_physiology0.96524317
104MP0002249_abnormal_larynx_morphology0.96076821
105MP0005310_abnormal_salivary_gland0.94909243
106MP0002722_abnormal_immune_system0.94736772
107MP0002557_abnormal_social/conspecific_i0.94309642
108MP0001968_abnormal_touch/_nociception0.93260675
109MP0000313_abnormal_cell_death0.93096976
110MP0001853_heart_inflammation0.92078254
111MP0003300_gastrointestinal_ulcer0.91040463
112MP0000716_abnormal_immune_system0.90931627
113MP0002081_perinatal_lethality0.90923046
114MP0001697_abnormal_embryo_size0.89904930
115MP0000631_abnormal_neuroendocrine_gland0.89861789
116MP0001440_abnormal_grooming_behavior0.89707011
117MP0002080_prenatal_lethality0.88966451
118MP0001270_distended_abdomen0.87753096
119MP0000689_abnormal_spleen_morphology0.87078468
120MP0010630_abnormal_cardiac_muscle0.86902979
121MP0003453_abnormal_keratinocyte_physiol0.86130256
122MP0002735_abnormal_chemical_nociception0.86127890
123MP0006072_abnormal_retinal_apoptosis0.84907070
124MP0000534_abnormal_ureter_morphology0.84558209
125MP0001293_anophthalmia0.84038936
126MP0003938_abnormal_ear_development0.83989909
127MP0004197_abnormal_fetal_growth/weight/0.83675953
128MP0002085_abnormal_embryonic_tissue0.83125895
129MP0003091_abnormal_cell_migration0.82673324
130MP0002114_abnormal_axial_skeleton0.82642733
131MP0004133_heterotaxia0.82199282
132MP0002734_abnormal_mechanical_nocicepti0.82159626
133MP0002429_abnormal_blood_cell0.81623977
134MP0003632_abnormal_nervous_system0.80868428
135MP0009672_abnormal_birth_weight0.80546421
136MP0002405_respiratory_system_inflammati0.80539694
137MP0002234_abnormal_pharynx_morphology0.80277297
138MP0002086_abnormal_extraembryonic_tissu0.79964675
139MP0003705_abnormal_hypodermis_morpholog0.79241171
140MP0010769_abnormal_survival0.79232063
141MP0002932_abnormal_joint_morphology0.78546288
142MP0009333_abnormal_splenocyte_physiolog0.78342578
143MP0003303_peritoneal_inflammation0.78296129
144MP0003786_premature_aging0.77698329
145MP0000685_abnormal_immune_system0.77594317
146MP0003937_abnormal_limbs/digits/tail_de0.76857429
147MP0003890_abnormal_embryonic-extraembry0.76555668
148MP0001177_atelectasis0.76543031
149MP0010768_mortality/aging0.76110213
150MP0002420_abnormal_adaptive_immunity0.76037092
151MP0000751_myopathy0.75820574
152MP0002082_postnatal_lethality0.74794767
153MP0010770_preweaning_lethality0.74794767
154MP0010307_abnormal_tumor_latency0.74566229
155MP0001784_abnormal_fluid_regulation0.74512066
156MP0000049_abnormal_middle_ear0.74403340
157MP0005384_cellular_phenotype0.74121469
158MP0002092_abnormal_eye_morphology0.73810557
159MP0001849_ear_inflammation0.73296356
160MP0003943_abnormal_hepatobiliary_system0.73231299
161MP0001819_abnormal_immune_cell0.72975915
162MP0000266_abnormal_heart_morphology0.71618486
163MP0005187_abnormal_penis_morphology0.71108669
164MP0004233_abnormal_muscle_weight0.70230646
165MP0003948_abnormal_gas_homeostasis0.68423401
166MP0002998_abnormal_bone_remodeling0.67294351

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.26841302
2Deep palmar crease (HP:0006191)3.17470993
3Abnormality of the aortic arch (HP:0012303)3.10275756
4Short 4th metacarpal (HP:0010044)3.01348003
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.01348003
6Hyperacusis (HP:0010780)2.77476248
7Dysmetric saccades (HP:0000641)2.75851686
8High anterior hairline (HP:0009890)2.65771384
9Shallow orbits (HP:0000586)2.61768072
10Dislocated radial head (HP:0003083)2.48578561
11Colitis (HP:0002583)2.44582643
12Macroorchidism (HP:0000053)2.43934166
13Acute lymphatic leukemia (HP:0006721)2.41066718
14Neoplasm of the heart (HP:0100544)2.40638251
15Neonatal hypoglycemia (HP:0001998)2.40399821
16Volvulus (HP:0002580)2.40046329
17Broad face (HP:0000283)2.39660733
18Sandal gap (HP:0001852)2.34200875
19Abnormality of the radial head (HP:0003995)2.31064225
20Supernumerary ribs (HP:0005815)2.27351482
21Vertebral arch anomaly (HP:0008438)2.26711232
22Sparse lateral eyebrow (HP:0005338)2.25577344
23Genetic anticipation (HP:0003743)2.23475348
24Heterotopia (HP:0002282)2.20557809
25Focal seizures (HP:0007359)2.20392041
26Insomnia (HP:0100785)2.20094232
27Broad metatarsal (HP:0001783)2.19059606
28Obsessive-compulsive behavior (HP:0000722)2.18625880
29Acute myeloid leukemia (HP:0004808)2.18094014
30Aqueductal stenosis (HP:0002410)2.16187514
31Trigonocephaly (HP:0000243)2.15018051
32Elfin facies (HP:0004428)2.14096503
33Abnormality of incisor morphology (HP:0011063)2.13785189
34Abnormality of the columella (HP:0009929)2.13215961
35Abnormality of the thoracic spine (HP:0100711)2.09990410
36Renal duplication (HP:0000075)2.09494962
37Renovascular hypertension (HP:0100817)2.09029062
38Chromsome breakage (HP:0040012)2.08865832
39Pointed chin (HP:0000307)2.08692937
40Abnormality of the 4th metacarpal (HP:0010012)2.07393769
41Bowel incontinence (HP:0002607)2.07045835
42Midline defect of the nose (HP:0004122)2.06523386
4311 pairs of ribs (HP:0000878)2.06393663
44Supernumerary bones of the axial skeleton (HP:0009144)2.05491631
45Truncus arteriosus (HP:0001660)2.04735246
46Prominent nose (HP:0000448)2.04223267
47Patellar dislocation (HP:0002999)2.04097805
48Narrow palate (HP:0000189)2.04090903
49Excessive salivation (HP:0003781)2.03999527
50Drooling (HP:0002307)2.03999527
51Overriding aorta (HP:0002623)2.00238592
52Long eyelashes (HP:0000527)1.97711023
53Abnormality of the incisor (HP:0000676)1.97431834
54Obstructive sleep apnea (HP:0002870)1.96861878
55Disproportionate tall stature (HP:0001519)1.94971939
56Abnormality of cells of the erythroid lineage (HP:0012130)1.93036674
57Annular pancreas (HP:0001734)1.92889129
58Bell-shaped thorax (HP:0001591)1.90746949
59Bronchomalacia (HP:0002780)1.89293769
60Hemiplegia (HP:0002301)1.86335386
61Limited elbow extension (HP:0001377)1.85779386
62Anteriorly placed anus (HP:0001545)1.84286145
63Impulsivity (HP:0100710)1.83691826
64Urethral obstruction (HP:0000796)1.81802672
65Metaphyseal cupping (HP:0003021)1.81682725
66Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.81430364
67Onion bulb formation (HP:0003383)1.81188386
68Ectopic kidney (HP:0000086)1.80837647
69Visual hallucinations (HP:0002367)1.80778030
70Basal cell carcinoma (HP:0002671)1.80567688
71Increased nuchal translucency (HP:0010880)1.80526142
72Chromosomal breakage induced by crosslinking agents (HP:0003221)1.80160297
73Lower limb amyotrophy (HP:0007210)1.80068008
74Cerebral aneurysm (HP:0004944)1.79606404
75Abnormality of the distal phalanx of the thumb (HP:0009617)1.78956087
76Abnormal large intestine physiology (HP:0012700)1.78543219
77Abnormality of the astrocytes (HP:0100707)1.76861122
78Astrocytoma (HP:0009592)1.76861122
79Tented upper lip vermilion (HP:0010804)1.76691610
80Absent frontal sinuses (HP:0002688)1.76257641
81Hypoplasia of the maxilla (HP:0000327)1.75338852
82Flat cornea (HP:0007720)1.74835965
83Pseudobulbar signs (HP:0002200)1.74695838
84Uterine leiomyosarcoma (HP:0002891)1.74277793
85Leiomyosarcoma (HP:0100243)1.74277793
86Chin dimple (HP:0010751)1.73945676
87Long palpebral fissure (HP:0000637)1.73838811
88Tapered finger (HP:0001182)1.73834860
89Thoracic kyphosis (HP:0002942)1.73550674
90Gastrointestinal inflammation (HP:0004386)1.73185715
91Tracheomalacia (HP:0002779)1.72593589
92Ulnar bowing (HP:0003031)1.72362250
93Mitral regurgitation (HP:0001653)1.71924145
94Open mouth (HP:0000194)1.71621454
95Neoplasm of the oral cavity (HP:0100649)1.71515916
96Broad thumb (HP:0011304)1.70258823
97Broad distal phalanx of finger (HP:0009836)1.69849812
98Abnormality of DNA repair (HP:0003254)1.69821058
99Hypoplastic labia majora (HP:0000059)1.69668181
100Overlapping toe (HP:0001845)1.69655883
101Hemiparesis (HP:0001269)1.69625090
102Sacral dimple (HP:0000960)1.69437662
103Spinal cord lesions (HP:0100561)1.68604465
104Syringomyelia (HP:0003396)1.68604465
105Atelectasis (HP:0100750)1.68603613
106Anal stenosis (HP:0002025)1.68330165
107Deep philtrum (HP:0002002)1.68007801
108Broad finger (HP:0001500)1.67882084
109Self-mutilation (HP:0000742)1.67123432
110Skull defect (HP:0001362)1.66782885
111Transitional cell carcinoma of the bladder (HP:0006740)1.66648738
112Attention deficit hyperactivity disorder (HP:0007018)1.66307557
113Septate vagina (HP:0001153)1.66273981
114Seborrheic dermatitis (HP:0001051)1.66134961
115Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.66020545
116Abnormality of cochlea (HP:0000375)1.65751850
117Bowel diverticulosis (HP:0005222)1.65422506
118Diastasis recti (HP:0001540)1.64925638
119Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.64868635
120Bladder diverticulum (HP:0000015)1.64510383
121Distal lower limb amyotrophy (HP:0008944)1.64484816
122Inappropriate behavior (HP:0000719)1.63824238
123Polycystic kidney dysplasia (HP:0000113)1.63555589
124Hyperthyroidism (HP:0000836)1.63189456
125Persistence of primary teeth (HP:0006335)1.63062724
126Smooth philtrum (HP:0000319)1.62961221
127Aplasia/Hypoplasia of the thymus (HP:0010515)1.62903920
128Hypoplastic ischia (HP:0003175)1.62865668
129Bladder neoplasm (HP:0009725)1.62139241
130Bladder carcinoma (HP:0002862)1.62139241
131Impaired smooth pursuit (HP:0007772)1.61961778
132Broad phalanges of the hand (HP:0009768)1.60933653
133Abnormality of the lower motor neuron (HP:0002366)1.60399213
134Arnold-Chiari malformation (HP:0002308)1.60380977
135Supranuclear gaze palsy (HP:0000605)1.59861525
136Oligodactyly (hands) (HP:0001180)1.58763222
137Abnormal number of incisors (HP:0011064)1.57649036
138Abnormality of the diencephalon (HP:0010662)1.57228807
139Lip pit (HP:0100267)1.56964761
140Abnormality of the antihelix (HP:0009738)1.56826708
141Progressive cerebellar ataxia (HP:0002073)1.56292137
142Abnormality of the parietal bone (HP:0002696)1.55724652
143Broad phalanx (HP:0006009)1.55518245
144Epileptic encephalopathy (HP:0200134)1.55447415
145Abnormality of the right ventricle (HP:0001707)1.54579553
146Hyperkalemia (HP:0002153)1.53473339
147Ependymoma (HP:0002888)1.52593085
148Broad-based gait (HP:0002136)1.52535070
149Thick eyebrow (HP:0000574)1.51501833
150Spina bifida occulta (HP:0003298)1.51339508
151Glioma (HP:0009733)1.50978636
152Oligodontia (HP:0000677)1.50762741
153Truncal obesity (HP:0001956)1.50460713
154Cutaneous finger syndactyly (HP:0010554)1.50018019
155Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.48902877
156Narrow nasal bridge (HP:0000446)1.48740193
157Abnormality of the labia majora (HP:0012881)1.48702547
158Skin tags (HP:0010609)1.48376312
159Protruding tongue (HP:0010808)1.48165041
160Vesicoureteral reflux (HP:0000076)1.47469438
161Stereotypic behavior (HP:0000733)1.47014006
162Broad palm (HP:0001169)1.46838142

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.97146796
2SIK23.25200321
3CDK123.05360338
4MAP3K102.56213573
5CAMK1G2.34718020
6MAP4K12.06849541
7DMPK1.97833316
8BRD41.91008493
9SMG11.81462073
10TYRO31.79367719
11NTRK21.79069213
12CAMK1D1.74200989
13TNIK1.72463601
14MARK11.69918100
15MARK21.66478889
16ALK1.64747564
17CDC42BPA1.63989270
18EEF2K1.57322335
19DDR21.55593050
20MAP3K71.54203339
21PDGFRA1.49774667
22FGFR41.49086376
23EPHA41.49023177
24RIPK11.42972385
25PNCK1.42624818
26MAP3K91.38707683
27TNK21.35774309
28PTK61.32600882
29DAPK21.29612979
30PAK61.28855092
31NEK21.24661276
32FES1.24055743
33WNK11.22755722
34FGFR21.22276069
35KSR11.21126432
36MTOR1.20067947
37ICK1.17525696
38TRIB31.15366453
39PDGFRB1.13549237
40TAOK11.13000649
41MAP2K31.08654177
42MKNK21.08651656
43MAPK111.07314890
44TTN1.04604967
45MAP3K41.03104138
46PKN21.01700788
47MAPK151.01410240
48MAPK131.00764721
49STK110.99564607
50SGK30.94094432
51BTK0.94043940
52MELK0.93996420
53PTK20.88589117
54SGK10.86883698
55SIK30.86713835
56WNK40.86638952
57TYK20.84864743
58ERN10.84675403
59RPS6KL10.84277758
60RPS6KC10.84277758
61SRPK10.83746435
62RPS6KB20.83345143
63AKT30.81574129
64CHUK0.80463232
65CDC70.79692310
66BLK0.79395226
67ZAP700.78646839
68SIK10.78089978
69MAP2K60.77340278
70CLK10.77288398
71STK30.76679888
72PRKD30.75994653
73PRKCH0.75970388
74DYRK1B0.75096157
75RPS6KA60.75091081
76ERBB20.74743113
77PAK20.74166393
78FGR0.73673547
79ATR0.73668116
80UHMK10.73593780
81ERBB30.72820812
82TTK0.72313943
83CDK50.71036613
84GSK3B0.70796887
85PRKD20.70523959
86MAPK80.69576387
87STK380.69187298
88SGK2230.68341527
89SGK4940.68341527
90CAMK40.68272568
91LMTK20.68222521
92PRPF4B0.68048059
93LATS20.67787432
94MKNK10.67735534
95PRKDC0.66705365
96STK100.66598722
97MAPK140.66348833
98MAPK100.66320572
99CSNK1E0.65458454
100MAP3K10.64997379
101CDK20.64688834
102CDK60.64202759
103FGFR30.62475254
104NLK0.61905509
105TAOK20.61717186
106MAP3K130.61681570
107MAPK120.60700077
108CHEK10.60285890
109LATS10.60092408
110SGK20.59920608
111RPS6KA30.58625846
112MAPK10.58607458
113JAK10.58039156
114AKT10.57772306
115EPHB20.57535216
116PDK10.57423846
117MAP3K60.57414072
118CDK70.56941434
119IRAK40.56798804
120MAP3K110.56583342
121KSR20.56109468
122ATM0.56072403
123PKN10.55724680
124PAK30.55294535
125CDK40.54701401
126CDK10.54377039
127PDPK10.54337010
128CDK90.54256321
129MARK30.54185775
130HCK0.53590201
131MAPK70.53368728
132CAMK10.53252532
133PTK2B0.52123963
134MAP2K20.51440478
135CSNK1D0.51214081
136DYRK1A0.50876906
137BMX0.50683569
138RPS6KA20.50569012
139CAMKK10.50165431
140JAK20.49657328
141PRKAA10.48975074
142RIPK40.47951605
143HIPK20.47403032
144RET0.47105443
145RPS6KA10.46034377
146EPHB10.46018064

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050331.89271932
2Long-term potentiation_Homo sapiens_hsa047201.82479498
3Glutamatergic synapse_Homo sapiens_hsa047241.74876622
4Circadian entrainment_Homo sapiens_hsa047131.70581610
5Type II diabetes mellitus_Homo sapiens_hsa049301.50742213
6Aldosterone synthesis and secretion_Homo sapiens_hsa049251.49472753
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.41461841
8Long-term depression_Homo sapiens_hsa047301.40363466
9Glioma_Homo sapiens_hsa052141.38679626
10Morphine addiction_Homo sapiens_hsa050321.35800168
11FoxO signaling pathway_Homo sapiens_hsa040681.35613609
12Axon guidance_Homo sapiens_hsa043601.32421245
13Amphetamine addiction_Homo sapiens_hsa050311.32344489
14Oxytocin signaling pathway_Homo sapiens_hsa049211.32100436
15Olfactory transduction_Homo sapiens_hsa047401.31995755
16Phosphatidylinositol signaling system_Homo sapiens_hsa040701.30585643
17Salivary secretion_Homo sapiens_hsa049701.30212080
18Dorso-ventral axis formation_Homo sapiens_hsa043201.29344090
19Spliceosome_Homo sapiens_hsa030401.28575217
20Lysine degradation_Homo sapiens_hsa003101.28487139
21GnRH signaling pathway_Homo sapiens_hsa049121.27716726
22Prolactin signaling pathway_Homo sapiens_hsa049171.25333793
23Estrogen signaling pathway_Homo sapiens_hsa049151.24711312
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22371434
25Insulin secretion_Homo sapiens_hsa049111.22280734
26Chronic myeloid leukemia_Homo sapiens_hsa052201.21610121
27GABAergic synapse_Homo sapiens_hsa047271.21439805
28ErbB signaling pathway_Homo sapiens_hsa040121.20251906
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20122389
30Taste transduction_Homo sapiens_hsa047421.19759724
31Notch signaling pathway_Homo sapiens_hsa043301.19748646
32Osteoclast differentiation_Homo sapiens_hsa043801.19589074
33Thyroid hormone signaling pathway_Homo sapiens_hsa049191.18941303
34mTOR signaling pathway_Homo sapiens_hsa041501.18131625
35Gastric acid secretion_Homo sapiens_hsa049711.18071269
36Hepatitis B_Homo sapiens_hsa051611.17916504
37Renin secretion_Homo sapiens_hsa049241.17821893
38Dopaminergic synapse_Homo sapiens_hsa047281.17435266
39Basal cell carcinoma_Homo sapiens_hsa052171.16634567
40Thyroid cancer_Homo sapiens_hsa052161.15809269
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15807648
42Cholinergic synapse_Homo sapiens_hsa047251.15622952
43cAMP signaling pathway_Homo sapiens_hsa040241.15324606
44Choline metabolism in cancer_Homo sapiens_hsa052311.13961261
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12530430
46MicroRNAs in cancer_Homo sapiens_hsa052061.11112894
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11082296
48Phospholipase D signaling pathway_Homo sapiens_hsa040721.10226307
49mRNA surveillance pathway_Homo sapiens_hsa030151.09491122
50Wnt signaling pathway_Homo sapiens_hsa043101.06849041
51Dilated cardiomyopathy_Homo sapiens_hsa054141.05988393
52Calcium signaling pathway_Homo sapiens_hsa040201.04781821
53Melanogenesis_Homo sapiens_hsa049161.03165610
54MAPK signaling pathway_Homo sapiens_hsa040101.02327371
55Gap junction_Homo sapiens_hsa045401.01901630
56Neurotrophin signaling pathway_Homo sapiens_hsa047221.01043393
57Endometrial cancer_Homo sapiens_hsa052131.00934013
58Other glycan degradation_Homo sapiens_hsa005110.99139089
59Hedgehog signaling pathway_Homo sapiens_hsa043400.98994875
60Colorectal cancer_Homo sapiens_hsa052100.98510938
61B cell receptor signaling pathway_Homo sapiens_hsa046620.98263191
62Non-small cell lung cancer_Homo sapiens_hsa052230.98233874
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98209731
64Insulin signaling pathway_Homo sapiens_hsa049100.97837334
65Proteoglycans in cancer_Homo sapiens_hsa052050.96869405
66Focal adhesion_Homo sapiens_hsa045100.96334785
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95897594
68Cocaine addiction_Homo sapiens_hsa050300.95497270
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95201375
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94895512
71VEGF signaling pathway_Homo sapiens_hsa043700.93755448
72Viral carcinogenesis_Homo sapiens_hsa052030.92979993
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.92938578
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.92694213
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92617374
76Renal cell carcinoma_Homo sapiens_hsa052110.91362411
77Circadian rhythm_Homo sapiens_hsa047100.90921231
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.90794754
79Herpes simplex infection_Homo sapiens_hsa051680.90319415
80Adherens junction_Homo sapiens_hsa045200.88889969
81Insulin resistance_Homo sapiens_hsa049310.87801061
82Phototransduction_Homo sapiens_hsa047440.87180743
83TNF signaling pathway_Homo sapiens_hsa046680.86988304
84Hippo signaling pathway_Homo sapiens_hsa043900.86548689
85AMPK signaling pathway_Homo sapiens_hsa041520.86404393
86Bladder cancer_Homo sapiens_hsa052190.86050883
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.85601719
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85518555
89Hepatitis C_Homo sapiens_hsa051600.84807816
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83953023
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.83795587
92Influenza A_Homo sapiens_hsa051640.83673359
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83431315
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83364068
95Epstein-Barr virus infection_Homo sapiens_hsa051690.82379882
96T cell receptor signaling pathway_Homo sapiens_hsa046600.81621433
97Primary immunodeficiency_Homo sapiens_hsa053400.80596378
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80285492
99Pancreatic cancer_Homo sapiens_hsa052120.79740766
100Cell cycle_Homo sapiens_hsa041100.79438061
101Small cell lung cancer_Homo sapiens_hsa052220.78643310
102Rap1 signaling pathway_Homo sapiens_hsa040150.78491161
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78436926
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77794025
105Prostate cancer_Homo sapiens_hsa052150.75666975
106Oocyte meiosis_Homo sapiens_hsa041140.75520951
107Serotonergic synapse_Homo sapiens_hsa047260.74876862
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74598490
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74323387
110Measles_Homo sapiens_hsa051620.74200777
111HIF-1 signaling pathway_Homo sapiens_hsa040660.74195872
112ECM-receptor interaction_Homo sapiens_hsa045120.73817934
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73424942
114Platelet activation_Homo sapiens_hsa046110.72922664
115Acute myeloid leukemia_Homo sapiens_hsa052210.72465648
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71709372
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69279608
118Pancreatic secretion_Homo sapiens_hsa049720.68448714
119Inositol phosphate metabolism_Homo sapiens_hsa005620.68418974
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67449273
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67288673
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66774073
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.66374267
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65574662
125HTLV-I infection_Homo sapiens_hsa051660.65459286
126Pathways in cancer_Homo sapiens_hsa052000.65411344
127Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65388222
128Chemokine signaling pathway_Homo sapiens_hsa040620.65221988
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65216720
130Apoptosis_Homo sapiens_hsa042100.64796296
131DNA replication_Homo sapiens_hsa030300.62955940
132NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62450555
133RNA transport_Homo sapiens_hsa030130.61582341
134Toxoplasmosis_Homo sapiens_hsa051450.60868338
135Central carbon metabolism in cancer_Homo sapiens_hsa052300.59244147
136Ras signaling pathway_Homo sapiens_hsa040140.59097178
137Fanconi anemia pathway_Homo sapiens_hsa034600.55809964
138Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53938830
139Endocytosis_Homo sapiens_hsa041440.49978288
140Leishmaniasis_Homo sapiens_hsa051400.46085955

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