SFT2D2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of pigment cell differentiation (GO:0050932)4.83662763
2interkinetic nuclear migration (GO:0022027)4.77826184
3positive regulation of developmental pigmentation (GO:0048087)4.70025158
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.61350312
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.61350312
6establishment of protein localization to Golgi (GO:0072600)4.58714665
7monoubiquitinated protein deubiquitination (GO:0035520)4.58435814
8cytoplasmic mRNA processing body assembly (GO:0033962)4.41105907
9regulation of establishment of cell polarity (GO:2000114)4.33303006
10antigen processing and presentation of endogenous antigen (GO:0019883)4.24287770
11regulation of translation, ncRNA-mediated (GO:0045974)4.17603002
12negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.17603002
13negative regulation of translation, ncRNA-mediated (GO:0040033)4.17603002
14snRNA transcription (GO:0009301)4.17005562
15cellular response to ethanol (GO:0071361)4.06875103
16lipid translocation (GO:0034204)4.05512347
17phospholipid translocation (GO:0045332)4.05512347
18protein K48-linked deubiquitination (GO:0071108)4.03593208
19protein targeting to vacuole (GO:0006623)3.84437353
20protein targeting to lysosome (GO:0006622)3.84437353
21establishment of protein localization to vacuole (GO:0072666)3.84437353
22histone H3-K4 trimethylation (GO:0080182)3.77573549
23endosome to pigment granule transport (GO:0043485)3.73886102
24endosome to melanosome transport (GO:0035646)3.73886102
25protein K11-linked deubiquitination (GO:0035871)3.71187950
26regulation of establishment or maintenance of cell polarity (GO:0032878)3.69866515
27indolalkylamine metabolic process (GO:0006586)3.66783332
28alpha-linolenic acid metabolic process (GO:0036109)3.66253582
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.52510418
30negative regulation of systemic arterial blood pressure (GO:0003085)3.38130324
31signal peptide processing (GO:0006465)3.36563241
32neural tube formation (GO:0001841)3.36368375
33triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.35447077
34regulation of interferon-beta biosynthetic process (GO:0045357)3.34811223
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.33873974
36positive regulation of gamma-delta T cell activation (GO:0046645)3.33227188
37pericardium development (GO:0060039)3.33034316
38regulation of gamma-delta T cell differentiation (GO:0045586)3.28237437
39sulfur amino acid catabolic process (GO:0000098)3.26231119
40protein K63-linked deubiquitination (GO:0070536)3.24003280
41regulation of hippo signaling (GO:0035330)3.23666032
42phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.17782358
43protein targeting to Golgi (GO:0000042)3.16349114
44valine metabolic process (GO:0006573)3.15292282
45behavioral response to nicotine (GO:0035095)3.14369423
46negative regulation of sodium ion transport (GO:0010766)3.14026569
47retrograde transport, vesicle recycling within Golgi (GO:0000301)3.12592402
48epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.07203443
49regulation of cholesterol homeostasis (GO:2000188)3.04445933
50regulation of triglyceride catabolic process (GO:0010896)3.02170493
51urea cycle (GO:0000050)3.02023112
52urea metabolic process (GO:0019627)3.02023112
53oxidative demethylation (GO:0070989)3.00053890
54erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.98003197
55L-phenylalanine catabolic process (GO:0006559)2.98003197
56phospholipid efflux (GO:0033700)2.97781966
57mannose metabolic process (GO:0006013)2.97456445
58glucocorticoid receptor signaling pathway (GO:0042921)2.96068069
59ethanol oxidation (GO:0006069)2.95228043
60regulation of gamma-delta T cell activation (GO:0046643)2.94305025
61nucleus localization (GO:0051647)2.93821087
62protein carboxylation (GO:0018214)2.89087701
63peptidyl-glutamic acid carboxylation (GO:0017187)2.89087701
64cysteine metabolic process (GO:0006534)2.88802426
65L-phenylalanine metabolic process (GO:0006558)2.85478456
66erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.85478456
67negative regulation of protein localization to cell surface (GO:2000009)2.84642470
68negative regulation of cholesterol transport (GO:0032375)2.84027680
69negative regulation of sterol transport (GO:0032372)2.84027680
70cilium or flagellum-dependent cell motility (GO:0001539)2.83738065
71high-density lipoprotein particle remodeling (GO:0034375)2.83627206
72L-fucose catabolic process (GO:0042355)2.83612784
73fucose catabolic process (GO:0019317)2.83612784
74L-fucose metabolic process (GO:0042354)2.83612784
75cardiovascular system development (GO:0072358)2.83187483
76reverse cholesterol transport (GO:0043691)2.82942782
77peptidyl-lysine methylation (GO:0018022)2.82602431
78thyroid hormone metabolic process (GO:0042403)2.82465299
79growth hormone receptor signaling pathway (GO:0060396)2.82111104
80complement activation, alternative pathway (GO:0006957)2.81153422
81detection of light stimulus involved in visual perception (GO:0050908)2.79542614
82detection of light stimulus involved in sensory perception (GO:0050962)2.79542614
83cellular response to exogenous dsRNA (GO:0071360)2.78130692
84indole-containing compound metabolic process (GO:0042430)2.76319012
85peptidyl-lysine trimethylation (GO:0018023)2.75224979
86regulation of sarcomere organization (GO:0060297)2.74762987
87phospholipid homeostasis (GO:0055091)2.73361128
88flavonoid metabolic process (GO:0009812)2.73237371
89cerebellar Purkinje cell differentiation (GO:0021702)2.72654258
90ethanol metabolic process (GO:0006067)2.72136270
91hepatocyte apoptotic process (GO:0097284)2.71711255
92aromatic amino acid family catabolic process (GO:0009074)2.69533682
93plasma lipoprotein particle assembly (GO:0034377)2.69522818
94protein-lipid complex assembly (GO:0065005)2.68606627
95nitrogen cycle metabolic process (GO:0071941)2.67491840
96positive regulation of B cell differentiation (GO:0045579)2.67089139
97regulation of developmental pigmentation (GO:0048070)2.62517317
98negative regulation of mast cell activation (GO:0033004)2.62331161
99corticosteroid receptor signaling pathway (GO:0031958)2.61933603
100plasma lipoprotein particle clearance (GO:0034381)2.60367515
101serotonin metabolic process (GO:0042428)2.60186441
102regulation of posttranscriptional gene silencing (GO:0060147)2.59121316
103regulation of gene silencing by miRNA (GO:0060964)2.59121316
104regulation of gene silencing by RNA (GO:0060966)2.59121316
105kynurenine metabolic process (GO:0070189)2.58899039
106low-density lipoprotein particle clearance (GO:0034383)2.58538114
107histone H3-K9 methylation (GO:0051567)2.58352564
108pigment cell differentiation (GO:0050931)2.57150369
109NAD biosynthetic process (GO:0009435)2.53439419
110apoptotic cell clearance (GO:0043277)2.52021723
111hormone catabolic process (GO:0042447)2.51469833
112regulation of MHC class I biosynthetic process (GO:0045343)2.51341263
113intestinal cholesterol absorption (GO:0030299)2.51157442
114positive regulation of interferon-alpha production (GO:0032727)2.50564632
115endocardial cushion development (GO:0003197)2.50468639
116cholesterol efflux (GO:0033344)2.50381806
117modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.49843459
118positive regulation by organism of defense response of other organism involved in symbiotic interact2.49843459
119modulation by symbiont of host immune response (GO:0052553)2.49843459
120positive regulation by symbiont of host defense response (GO:0052509)2.49843459
121modulation by symbiont of host defense response (GO:0052031)2.49843459
122modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.49843459
123tryptophan catabolic process (GO:0006569)2.48960799
124indole-containing compound catabolic process (GO:0042436)2.48960799
125indolalkylamine catabolic process (GO:0046218)2.48960799
126protein localization to lysosome (GO:0061462)2.47952195
127protein localization to vacuole (GO:0072665)2.47952195
128regulation of cholesterol storage (GO:0010885)2.47486620
129JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.46874732
130homocysteine metabolic process (GO:0050667)2.46866969
131amino-acid betaine metabolic process (GO:0006577)2.46099133
132protein localization to Golgi apparatus (GO:0034067)2.45810525
133plasma lipoprotein particle remodeling (GO:0034369)2.45109599
134protein-lipid complex remodeling (GO:0034368)2.45109599
135macromolecular complex remodeling (GO:0034367)2.45109599
136positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.44618385
137tryptophan metabolic process (GO:0006568)2.42949033
138microtubule anchoring (GO:0034453)2.42742139
139embryonic hemopoiesis (GO:0035162)2.42297193
140replicative senescence (GO:0090399)2.42024022
141primary amino compound metabolic process (GO:1901160)2.41773452
142cellular response to growth hormone stimulus (GO:0071378)2.41691122
143negative regulation of cytosolic calcium ion concentration (GO:0051481)2.41497705
144amine catabolic process (GO:0009310)2.41453141
145cellular biogenic amine catabolic process (GO:0042402)2.41453141
146lysine metabolic process (GO:0006553)2.41242303
147lysine catabolic process (GO:0006554)2.41242303
148antigen processing and presentation via MHC class Ib (GO:0002475)2.41030611
149primary alcohol catabolic process (GO:0034310)2.40464066
150positive regulation of lipid catabolic process (GO:0050996)2.40369575
151bile acid and bile salt transport (GO:0015721)2.40355218
152complement activation, classical pathway (GO:0006958)2.40020732
153melanocyte differentiation (GO:0030318)2.39863642
154positive regulation of fatty acid beta-oxidation (GO:0032000)2.39106583
155positive regulation of histone deacetylation (GO:0031065)2.39001326
156cellular response to sterol (GO:0036315)2.38686312
157early endosome to late endosome transport (GO:0045022)2.38618829
158regulation of protein activation cascade (GO:2000257)2.38388196
159regulation of cholesterol esterification (GO:0010872)2.38340545
160cAMP catabolic process (GO:0006198)2.38075439
161lipoprotein metabolic process (GO:0042157)2.37825669
162transcytosis (GO:0045056)2.36822792
163reflex (GO:0060004)2.35906943
164macroautophagy (GO:0016236)2.35685402
165positive regulation of triglyceride metabolic process (GO:0090208)2.35584247
166negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.35293698
167bile acid biosynthetic process (GO:0006699)2.35275712
168cholesterol homeostasis (GO:0042632)2.35177743
169regulation of interferon-alpha production (GO:0032647)2.35101142
170intestinal absorption (GO:0050892)2.34889331
171peptide catabolic process (GO:0043171)2.34834020
172sterol homeostasis (GO:0055092)2.34641466
173detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.34102612
174complement activation (GO:0006956)2.32627779
175rRNA catabolic process (GO:0016075)2.31964733
176behavioral response to ethanol (GO:0048149)2.31622594
177positive regulation of triglyceride lipase activity (GO:0061365)2.30862115
178positive regulation of lipoprotein lipase activity (GO:0051006)2.30862115
179sulfation (GO:0051923)2.30839958
180appendage development (GO:0048736)2.30729110
181limb development (GO:0060173)2.30729110
182UDP-N-acetylglucosamine metabolic process (GO:0006047)2.30517733
183regulation of complement activation (GO:0030449)2.30435529
184striated muscle atrophy (GO:0014891)2.29912473
185cellular modified amino acid catabolic process (GO:0042219)2.29756976
186fatty acid oxidation (GO:0019395)2.29343074
187cell morphogenesis involved in neuron differentiation (GO:0048667)2.28368180
188protein-lipid complex subunit organization (GO:0071825)2.27744282
189histone H3-K9 modification (GO:0061647)2.27692770
190macrophage activation involved in immune response (GO:0002281)2.27559156
191fatty acid beta-oxidation (GO:0006635)2.27226276
192regulation of interleukin-12 biosynthetic process (GO:0045075)2.26621975
193neuron maturation (GO:0042551)2.26433958
194angiotensin maturation (GO:0002003)2.25951909

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.95144869
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.68082850
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.54159062
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.52092919
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.45208767
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.20554246
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.19422341
8GBX2_23144817_ChIP-Seq_PC3_Human2.92771641
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.87466652
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.75275738
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.69033452
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.66023410
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.62870750
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.55420085
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.46206356
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.38613188
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36802896
18GATA1_22025678_ChIP-Seq_K562_Human2.36156740
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.35384980
20EGR1_23403033_ChIP-Seq_LIVER_Mouse2.33243396
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.32736482
22* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30020989
23VDR_22108803_ChIP-Seq_LS180_Human2.23727082
24* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22910651
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.22196046
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.21178408
27SALL1_21062744_ChIP-ChIP_HESCs_Human2.18297663
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.17650338
29FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.15271843
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.13772828
31CLOCK_20551151_ChIP-Seq_293T_Human2.13122571
32EZH2_22144423_ChIP-Seq_EOC_Human2.10668747
33ZNF274_21170338_ChIP-Seq_K562_Hela2.10380294
34TAF15_26573619_Chip-Seq_HEK293_Human2.07927865
35TP53_16413492_ChIP-PET_HCT116_Human2.06026006
36* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.03255502
37* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.02983767
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.01757801
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.98045546
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.93679121
41STAT3_23295773_ChIP-Seq_U87_Human1.90645846
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89220551
43RUNX_20019798_ChIP-Seq_JUKART_Human1.84706242
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84455971
45NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.84403166
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.84323842
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.83969465
48SCL_19346495_ChIP-Seq_HPC-7_Human1.83665372
49ER_23166858_ChIP-Seq_MCF-7_Human1.82227714
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.81381965
51STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.81068307
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.80690360
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80183536
54SMAD4_21799915_ChIP-Seq_A2780_Human1.79882878
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.78847086
56* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.77605376
57Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.76339454
58* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75683410
59P300_19829295_ChIP-Seq_ESCs_Human1.74287438
60CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.73962417
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.72351881
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.71629112
63FOXO3_23340844_ChIP-Seq_DLD1_Human1.71535876
64AR_21572438_ChIP-Seq_LNCaP_Human1.69915626
65FUS_26573619_Chip-Seq_HEK293_Human1.67734384
66EWS_26573619_Chip-Seq_HEK293_Human1.65972480
67TCF4_23295773_ChIP-Seq_U87_Human1.62867778
68AHR_22903824_ChIP-Seq_MCF-7_Human1.62181325
69ESR1_21235772_ChIP-Seq_MCF-7_Human1.61569934
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58516626
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.58516626
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58418416
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.57538871
74* MAF_26560356_Chip-Seq_TH1_Human1.56652355
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.56612069
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53953568
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53657124
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.53160238
79BCAT_22108803_ChIP-Seq_LS180_Human1.53053323
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51825676
81VDR_21846776_ChIP-Seq_THP-1_Human1.51397838
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51375317
83TCF7_22412390_ChIP-Seq_EML_Mouse1.51257332
84* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50480073
85TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50216881
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.48860322
87FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48323642
88BP1_19119308_ChIP-ChIP_Hs578T_Human1.48191608
89GATA2_21666600_ChIP-Seq_HMVEC_Human1.48041243
90IGF1R_20145208_ChIP-Seq_DFB_Human1.47411104
91MYC_22102868_ChIP-Seq_BL_Human1.47071392
92MYB_26560356_Chip-Seq_TH2_Human1.46555678
93CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46517349
94* AR_25329375_ChIP-Seq_VCAP_Human1.43845427
95E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.43358286
96RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42946861
97PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41630056
98SMAD3_21741376_ChIP-Seq_EPCs_Human1.41276018
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39817011
100CBP_20019798_ChIP-Seq_JUKART_Human1.39589187
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39589187
102* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.38882335
103* GATA4_25053715_ChIP-Seq_YYC3_Human1.37607638
104* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37116681
105VDR_24763502_ChIP-Seq_THP-1_Human1.37011894
106SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36271155
107MYB_26560356_Chip-Seq_TH1_Human1.34649042
108CDX2_20551321_ChIP-Seq_CACO-2_Human1.33489979
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33240333
110RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.33061076
111EZH2_27294783_Chip-Seq_NPCs_Mouse1.30522996
112PRDM14_20953172_ChIP-Seq_ESCs_Human1.30449368
113TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29461900
114OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29325939
115SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29078278
116ELK3_25401928_ChIP-Seq_HUVEC_Human1.28768288
117* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28082507
118PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27199580
119UTX_26944678_Chip-Seq_JUKART_Human1.25727209
120* GATA6_25053715_ChIP-Seq_YYC3_Human1.25665634
121CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25008858
122RUNX2_22187159_ChIP-Seq_PCA_Human1.24963180
123* NANOG_18555785_Chip-Seq_ESCs_Mouse1.24935243
124TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24922809
125* RUNX1_22412390_ChIP-Seq_EML_Mouse1.24104031
126EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23411203
127NFE2_27457419_Chip-Seq_LIVER_Mouse1.23313841
128FOXM1_26456572_ChIP-Seq_MCF-7_Human1.23166541
129STAT4_19710469_ChIP-ChIP_TH1__Mouse1.22819249
130KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21724130
131ZNF263_19887448_ChIP-Seq_K562_Human1.21636029
132FLI1_21867929_ChIP-Seq_TH2_Mouse1.21630537
133SOX2_20726797_ChIP-Seq_SW620_Human1.21112909
134FOXA2_19822575_ChIP-Seq_HepG2_Human1.20918028
135SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20835094
136ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.20742705
137CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20504966
138THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19843512
139TCF4_22108803_ChIP-Seq_LS180_Human1.19269415
140NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19260987
141NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19260987
142SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19163010
143SPI1_23127762_ChIP-Seq_K562_Human1.18216874
144SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17119874
145GATA1_19941826_ChIP-Seq_K562_Human1.16781192
146RXR_22108803_ChIP-Seq_LS180_Human1.16349419
147HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.15545978
148GATA2_19941826_ChIP-Seq_K562_Human1.15402951
149CJUN_26792858_Chip-Seq_BT549_Human1.15398805
150* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.15027282
151KDM2B_26808549_Chip-Seq_REH_Human1.13671627
152* E2F1_18555785_Chip-Seq_ESCs_Mouse1.13603537
153RACK7_27058665_Chip-Seq_MCF-7_Human1.12910468
154* P53_22387025_ChIP-Seq_ESCs_Mouse1.12803422
155KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12783677
156ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12526937
157ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12313353
158EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12065826
159* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11986642
160KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11481222
161* DROSHA_22980978_ChIP-Seq_HELA_Human1.10478605
162SOX2_21211035_ChIP-Seq_LN229_Gbm1.10218553
163SMAD4_21741376_ChIP-Seq_EPCs_Human1.09620494
164* PU_27001747_Chip-Seq_BMDM_Mouse1.09011544
165P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08874649
166ESR1_20079471_ChIP-ChIP_T-47D_Human1.08253453
167* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06926633
168GATA3_27048872_Chip-Seq_THYMUS_Human1.05766966
169TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05706811
170CDX2_22108803_ChIP-Seq_LS180_Human1.05451807
171SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05313599
172TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.05228585
173GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05181601
174TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04845280
175TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04769075
176* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04532769
177* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04532769
178KDM2B_26808549_Chip-Seq_DND41_Human1.04408722
179TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04314353
180PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03932338
181* CMYC_18555785_Chip-Seq_ESCs_Mouse1.03840617
182FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03297677
183SPI1_23547873_ChIP-Seq_NB4_Human1.03129884
184GATA1_19941827_ChIP-Seq_MEL_Mouse1.02955617
185* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02613589
186* CRX_20693478_ChIP-Seq_RETINA_Mouse1.02565509
187CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02542925
188RUNX1_27514584_Chip-Seq_MCF-7_Human1.02173558
189VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01831756
190LXR_22292898_ChIP-Seq_THP-1_Human1.01372181
191CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.01056905
192ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00826459
193* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00820233
194EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99911685
195VDR_24787735_ChIP-Seq_THP-1_Human0.98590425

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation7.74200769
2MP0008057_abnormal_DNA_replication4.79920139
3MP0003195_calcinosis4.03252185
4MP0005360_urolithiasis3.63888060
5MP0002139_abnormal_hepatobiliary_system3.53676180
6MP0003787_abnormal_imprinting2.86206964
7MP0003300_gastrointestinal_ulcer2.85670700
8MP0000427_abnormal_hair_cycle2.83962602
9MP0010234_abnormal_vibrissa_follicle2.78851909
10MP0003646_muscle_fatigue2.67250018
11MP0003191_abnormal_cellular_cholesterol2.65069259
12MP0009840_abnormal_foam_cell2.60236008
13MP0005174_abnormal_tail_pigmentation2.60044863
14MP0005365_abnormal_bile_salt2.56670610
15MP0005085_abnormal_gallbladder_physiolo2.53357280
16MP0004043_abnormal_pH_regulation2.51015477
17MP0003890_abnormal_embryonic-extraembry2.47414493
18MP0000383_abnormal_hair_follicle2.40754750
19MP0008961_abnormal_basal_metabolism2.32909585
20MP0003252_abnormal_bile_duct2.22514403
21MP0008875_abnormal_xenobiotic_pharmacok2.20798334
22MP0005058_abnormal_lysosome_morphology2.19925141
23MP0002009_preneoplasia2.19781391
24MP0001835_abnormal_antigen_presentation2.17500496
25MP0001666_abnormal_nutrient_absorption2.07539507
26MP0009046_muscle_twitch2.01739328
27MP0010329_abnormal_lipoprotein_level2.01134632
28MP0003436_decreased_susceptibility_to1.97751239
29MP0002166_altered_tumor_susceptibility1.97211356
30MP0000015_abnormal_ear_pigmentation1.95444694
31MP0000685_abnormal_immune_system1.89351556
32MP0008877_abnormal_DNA_methylation1.89311539
33MP0003705_abnormal_hypodermis_morpholog1.78151291
34MP0004947_skin_inflammation1.77920777
35MP0005551_abnormal_eye_electrophysiolog1.75704337
36MP0006082_CNS_inflammation1.73046333
37MP0002138_abnormal_hepatobiliary_system1.70903773
38MP0001501_abnormal_sleep_pattern1.69139632
39MP0005464_abnormal_platelet_physiology1.68637805
40MP0001873_stomach_inflammation1.66745929
41MP0002928_abnormal_bile_duct1.66590090
42MP0000371_diluted_coat_color1.66168673
43MP0002254_reproductive_system_inflammat1.65381281
44MP0010155_abnormal_intestine_physiology1.62474395
45MP0002095_abnormal_skin_pigmentation1.61926288
46MP0003303_peritoneal_inflammation1.57858969
47MP0000609_abnormal_liver_physiology1.55176766
48MP0002419_abnormal_innate_immunity1.53173440
49MP0001790_abnormal_immune_system1.50396116
50MP0005387_immune_system_phenotype1.50396116
51MP0001800_abnormal_humoral_immune1.49466478
52MP0002168_other_aberrant_phenotype1.49464462
53MP0004264_abnormal_extraembryonic_tissu1.49034898
54MP0009785_altered_susceptibility_to1.48692885
55MP0005025_abnormal_response_to1.48223681
56MP0004142_abnormal_muscle_tone1.45241101
57MP0003950_abnormal_plasma_membrane1.42612972
58MP0003724_increased_susceptibility_to1.41869512
59MP0002452_abnormal_antigen_presenting1.40377143
60MP0000465_gastrointestinal_hemorrhage1.38643278
61MP0002876_abnormal_thyroid_physiology1.37645768
62MP0006054_spinal_hemorrhage1.37301992
63MP0003566_abnormal_cell_adhesion1.35472368
64MP0005671_abnormal_response_to1.34628062
65MP0009643_abnormal_urine_homeostasis1.33607690
66MP0004924_abnormal_behavior1.33384009
67MP0005386_behavior/neurological_phenoty1.33384009
68MP0010386_abnormal_urinary_bladder1.32708357
69MP0002006_tumorigenesis1.31836381
70MP0002796_impaired_skin_barrier1.30642114
71MP0005000_abnormal_immune_tolerance1.29355003
72MP0004381_abnormal_hair_follicle1.28631655
73MP0001845_abnormal_inflammatory_respons1.28216971
74MP0002723_abnormal_immune_serum1.26012078
75MP0005332_abnormal_amino_acid1.25762458
76MP0003453_abnormal_keratinocyte_physiol1.25147150
77MP0008469_abnormal_protein_level1.23018847
78MP0002118_abnormal_lipid_homeostasis1.22240804
79MP0001485_abnormal_pinna_reflex1.21951834
80MP0001533_abnormal_skeleton_physiology1.20570599
81MP0009115_abnormal_fat_cell1.19536037
82MP0001819_abnormal_immune_cell1.18576571
83MP0002420_abnormal_adaptive_immunity1.17950876
84MP0002148_abnormal_hypersensitivity_rea1.17889958
85MP0009764_decreased_sensitivity_to1.17451232
86MP0003806_abnormal_nucleotide_metabolis1.15936547
87MP0004019_abnormal_vitamin_homeostasis1.15450129
88MP0001853_heart_inflammation1.15310315
89MP0003866_abnormal_defecation1.14866045
90MP0002837_dystrophic_cardiac_calcinosis1.12965504
91MP0005310_abnormal_salivary_gland1.12287831
92MP0005319_abnormal_enzyme/_coenzyme1.11220187
93MP0003183_abnormal_peptide_metabolism1.10656112
94MP0010352_gastrointestinal_tract_polyps1.09958039
95MP0005171_absent_coat_pigmentation1.09524718
96MP0005266_abnormal_metabolism1.09259905
97MP0000470_abnormal_stomach_morphology1.08280896
98MP0005083_abnormal_biliary_tract1.07237812
99MP0003075_altered_response_to1.06074645
100MP0003690_abnormal_glial_cell1.05703350
101MP0010678_abnormal_skin_adnexa1.04881972
102MP0002136_abnormal_kidney_physiology1.04075834
103MP0004130_abnormal_muscle_cell1.03132415
104MP0002405_respiratory_system_inflammati1.03116786
105MP0009745_abnormal_behavioral_response1.02840457
106MP0005646_abnormal_pituitary_gland1.02698474
107MP0003172_abnormal_lysosome_physiology1.02042978
108MP0000631_abnormal_neuroendocrine_gland1.00576038
109MP0004185_abnormal_adipocyte_glucose1.00434422
110MP0001324_abnormal_eye_pigmentation1.00266579
111MP0000372_irregular_coat_pigmentation0.98938920
112MP0000604_amyloidosis0.98757017
113MP0005166_decreased_susceptibility_to0.98626527
114MP0001968_abnormal_touch/_nociception0.98043926
115MP0000230_abnormal_systemic_arterial0.97594107
116MP0005584_abnormal_enzyme/coenzyme_acti0.97451269
117MP0002396_abnormal_hematopoietic_system0.97119594
118MP0005023_abnormal_wound_healing0.96377707
119MP0009278_abnormal_bone_marrow0.96038904
120MP0005253_abnormal_eye_physiology0.95260258
121MP0005448_abnormal_energy_balance0.94727269
122MP0001216_abnormal_epidermal_layer0.93241636
123MP0005167_abnormal_blood-brain_barrier0.93112452
124MP0000716_abnormal_immune_system0.92516804
125MP0002067_abnormal_sensory_capabilities0.92237263
126MP0005075_abnormal_melanosome_morpholog0.91837016
127MP0002060_abnormal_skin_morphology0.91573094
128MP0005645_abnormal_hypothalamus_physiol0.91261549
129MP0000598_abnormal_liver_morphology0.90798750
130MP0003632_abnormal_nervous_system0.90134520
131MP0003045_fibrosis0.89931313
132MP0000538_abnormal_urinary_bladder0.88760017
133MP0003136_yellow_coat_color0.88528131
134MP0003763_abnormal_thymus_physiology0.88127673
135MP0005647_abnormal_sex_gland0.87558610
136MP0009763_increased_sensitivity_to0.86756414
137MP0000689_abnormal_spleen_morphology0.86061875
138MP0002638_abnormal_pupillary_reflex0.84926077
139MP0002398_abnormal_bone_marrow0.84882577
140MP0002102_abnormal_ear_morphology0.84674585
141MP0003633_abnormal_nervous_system0.84084737
142MP0001986_abnormal_taste_sensitivity0.83846794
143MP0005666_abnormal_adipose_tissue0.83389742
144MP0003656_abnormal_erythrocyte_physiolo0.82891388
145MP0000647_abnormal_sebaceous_gland0.82869240
146MP0000858_altered_metastatic_potential0.82467140
147MP0002557_abnormal_social/conspecific_i0.81556611
148MP0000343_altered_response_to0.81079244
149MP0000778_abnormal_nervous_system0.80406950
150MP0001851_eye_inflammation0.79400607
151MP0002075_abnormal_coat/hair_pigmentati0.77637491
152MP0002722_abnormal_immune_system0.77298392
153MP0001756_abnormal_urination0.77296837
154MP0003943_abnormal_hepatobiliary_system0.77161138
155MP0002429_abnormal_blood_cell0.76537069
156MP0005408_hypopigmentation0.76495666
157MP0000249_abnormal_blood_vessel0.75941219
158MP0004885_abnormal_endolymph0.74623206
159MP0002693_abnormal_pancreas_physiology0.73722224
160MP0002064_seizures0.72923157
161MP0003631_nervous_system_phenotype0.72865600
162MP0002938_white_spotting0.72700817
163MP0002572_abnormal_emotion/affect_behav0.72698643
164MP0001663_abnormal_digestive_system0.72399379
165MP0002272_abnormal_nervous_system0.72232847
166MP0002933_joint_inflammation0.72015748
167MP0002998_abnormal_bone_remodeling0.71519943
168MP0006276_abnormal_autonomic_nervous0.71137797
169MP0005195_abnormal_posterior_eye0.69798870
170MP0008872_abnormal_physiological_respon0.69233833
171MP0002735_abnormal_chemical_nociception0.68537726
172MP0001486_abnormal_startle_reflex0.68032829
173MP0002332_abnormal_exercise_endurance0.66554895
174MP0005395_other_phenotype0.66442770
175MP0001970_abnormal_pain_threshold0.65519656
176MP0003868_abnormal_feces_composition0.63292640
177MP0002109_abnormal_limb_morphology0.63164895
178MP0002229_neurodegeneration0.62230657
179MP0004134_abnormal_chest_morphology0.60846366
180MP0002909_abnormal_adrenal_gland0.58696936

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)5.64863278
2Hyperventilation (HP:0002883)4.81101597
3Protruding tongue (HP:0010808)4.53427173
4Pancreatic cysts (HP:0001737)4.13152560
5Progressive cerebellar ataxia (HP:0002073)3.86915973
6Complement deficiency (HP:0004431)3.80475200
7Systemic lupus erythematosus (HP:0002725)3.79854231
8Gaze-evoked nystagmus (HP:0000640)3.67968053
9Deep venous thrombosis (HP:0002625)3.46641271
10Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.46091471
11Pancreatic fibrosis (HP:0100732)3.45499363
12Fair hair (HP:0002286)3.43230839
13Vacuolated lymphocytes (HP:0001922)3.41836921
14Xanthomatosis (HP:0000991)3.36857216
15Clumsiness (HP:0002312)3.17667809
16Intrahepatic cholestasis (HP:0001406)3.16537601
17True hermaphroditism (HP:0010459)3.15920937
18Abnormality of midbrain morphology (HP:0002418)3.08962400
19Molar tooth sign on MRI (HP:0002419)3.08962400
20Eczematoid dermatitis (HP:0000976)3.05702315
21Myocardial infarction (HP:0001658)3.05561374
22Glomerulonephritis (HP:0000099)3.04413399
23Abnormality of the renal cortex (HP:0011035)2.99880175
24Abnormality of monocarboxylic acid metabolism (HP:0010996)2.99244176
25Aplasia/Hypoplasia of the tibia (HP:0005772)2.96935772
26Abnormality of complement system (HP:0005339)2.96072697
27Chronic hepatic failure (HP:0100626)2.93465494
28Generalized hypopigmentation of hair (HP:0011358)2.89061181
29Interstitial pulmonary disease (HP:0006530)2.88523077
30Nephronophthisis (HP:0000090)2.87706722
31Widely spaced teeth (HP:0000687)2.85471611
32Abnormality of glutamine family amino acid metabolism (HP:0010902)2.84846046
33Abnormality of the renal medulla (HP:0100957)2.84484265
34Increased cerebral lipofuscin (HP:0011813)2.77759250
35Hematochezia (HP:0002573)2.76398029
36Tubular atrophy (HP:0000092)2.70459131
37Dysostosis multiplex (HP:0000943)2.67559900
38Recurrent gram-negative bacterial infections (HP:0005420)2.67501080
39Colitis (HP:0002583)2.65904766
40Recurrent bacterial skin infections (HP:0005406)2.65406762
41Autoimmune thrombocytopenia (HP:0001973)2.65039828
42Esophageal varix (HP:0002040)2.63545579
43Mucopolysacchariduria (HP:0008155)2.62111376
44Urinary glycosaminoglycan excretion (HP:0003541)2.62111376
45Cystic liver disease (HP:0006706)2.59894924
46Abnormality of the common coagulation pathway (HP:0010990)2.59723074
47Abnormality of aromatic amino acid family metabolism (HP:0004338)2.59060216
48Hypoplastic labia majora (HP:0000059)2.56521527
49Hypobetalipoproteinemia (HP:0003563)2.55405305
50Nephritis (HP:0000123)2.54309939
51Spontaneous hematomas (HP:0007420)2.53839811
52Abnormality of the axillary hair (HP:0100134)2.53718088
53Abnormality of secondary sexual hair (HP:0009888)2.53718088
54Hypoplastic ischia (HP:0003175)2.51848104
55Recurrent abscess formation (HP:0002722)2.51134168
56Joint hemorrhage (HP:0005261)2.50740360
57Congenital stationary night blindness (HP:0007642)2.48616304
58Hyperlipoproteinemia (HP:0010980)2.46313858
59Aortic aneurysm (HP:0004942)2.46296591
60Dysmetric saccades (HP:0000641)2.45657625
61Right ventricular cardiomyopathy (HP:0011663)2.43326743
62Abnormality of the ischium (HP:0003174)2.42926942
63Recurrent viral infections (HP:0004429)2.40096983
64Pustule (HP:0200039)2.37566884
65Abnormality of mucopolysaccharide metabolism (HP:0011020)2.37562591
66Abnormality of polysaccharide metabolism (HP:0011012)2.37562591
67Abnormality of glycosaminoglycan metabolism (HP:0004371)2.37562591
68Broad-based gait (HP:0002136)2.37278432
69Increased neuronal autofluorescent lipopigment (HP:0002074)2.37277762
70Febrile seizures (HP:0002373)2.36717780
71Fat malabsorption (HP:0002630)2.35712735
72Abnormality of the labia majora (HP:0012881)2.35321796
73Inflammation of the large intestine (HP:0002037)2.34160365
74Decreased circulating renin level (HP:0003351)2.33296223
75Abnormality of proline metabolism (HP:0010907)2.29999313
76Hydroxyprolinuria (HP:0003080)2.29999313
77Truncal obesity (HP:0001956)2.27745572
78Recurrent fungal infections (HP:0002841)2.27587464
79Medial flaring of the eyebrow (HP:0010747)2.25438651
80Attenuation of retinal blood vessels (HP:0007843)2.24193135
81Furrowed tongue (HP:0000221)2.23703994
82Gingival bleeding (HP:0000225)2.23412568
83Absent speech (HP:0001344)2.22823296
84Hyperammonemia (HP:0001987)2.22395009
85Gastrointestinal inflammation (HP:0004386)2.22376941
86Osteolytic defects of the hand bones (HP:0009699)2.22000479
87Osteolytic defects of the phalanges of the hand (HP:0009771)2.22000479
88Myositis (HP:0100614)2.21939090
89Cellulitis (HP:0100658)2.21697860
90Abnormal platelet function (HP:0011869)2.20986616
91Impaired platelet aggregation (HP:0003540)2.20986616
92Volvulus (HP:0002580)2.20952245
93Periodontitis (HP:0000704)2.20302183
94Amyloidosis (HP:0011034)2.19551410
95Hypercholesterolemia (HP:0003124)2.18356936
96Chronic otitis media (HP:0000389)2.17869010
97Congenital sensorineural hearing impairment (HP:0008527)2.17076051
98Hemorrhage of the eye (HP:0011885)2.16631131
99Increased IgE level (HP:0003212)2.14658069
100Hypolipoproteinemia (HP:0010981)2.14638366
101Blue irides (HP:0000635)2.14418842
102Abnormality of the intrinsic pathway (HP:0010989)2.14311474
103Macroglossia (HP:0000158)2.13360206
104Vascular calcification (HP:0004934)2.13027096
105Prolonged partial thromboplastin time (HP:0003645)2.13020894
106Abnormality of macrophages (HP:0004311)2.12556382
107Drooling (HP:0002307)2.11992462
108Poor coordination (HP:0002370)2.10851430
109Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.09493805
110Epidermoid cyst (HP:0200040)2.09236500
111Abnormal platelet volume (HP:0011876)2.04667348
112Thrombocytosis (HP:0001894)2.03783236
113Large for gestational age (HP:0001520)2.02918031
114Increased mean platelet volume (HP:0011877)2.02286462
115Abnormality of the nasal mucosa (HP:0000433)2.01836365
116Abnormality of sulfur amino acid metabolism (HP:0004339)2.01519215
117Hypoalphalipoproteinemia (HP:0003233)2.01501064
118Patellar aplasia (HP:0006443)2.01152278
119Congenital hepatic fibrosis (HP:0002612)2.00293246
120Elevated erythrocyte sedimentation rate (HP:0003565)2.00226612
121Axonal loss (HP:0003447)1.99980982
122Abnormality of fatty-acid metabolism (HP:0004359)1.99579120
123Recurrent skin infections (HP:0001581)1.99006570
124Birth length less than 3rd percentile (HP:0003561)1.98676098
125Arterial thrombosis (HP:0004420)1.98445518
126Polycythemia (HP:0001901)1.97859518
127Chronic diarrhea (HP:0002028)1.97841171
128Excessive salivation (HP:0003781)1.97442651
129Inability to walk (HP:0002540)1.96867897
130Acute myeloid leukemia (HP:0004808)1.95988844
131Hyperglycinuria (HP:0003108)1.95670541
132Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.95622787
133Aplasia/Hypoplasia of the tongue (HP:0010295)1.95497909
134Abnormality of the nasal septum (HP:0000419)1.94968327
135Gait imbalance (HP:0002141)1.94437330
136Ketosis (HP:0001946)1.93972723
137Cardiovascular calcification (HP:0011915)1.92486784
138Fatigue (HP:0012378)1.90984668
139Cerebral aneurysm (HP:0004944)1.90964536
140Polydipsia (HP:0001959)1.90389081
141Abnormal drinking behavior (HP:0030082)1.90389081
142Urinary bladder sphincter dysfunction (HP:0002839)1.90354629
143Highly arched eyebrow (HP:0002553)1.90222119
144Congenital primary aphakia (HP:0007707)1.89996916
145Tapered finger (HP:0001182)1.87890037
146Nasal polyposis (HP:0100582)1.87540558
147Orchitis (HP:0100796)1.86098629
148IgM deficiency (HP:0002850)1.85558039
149Short chin (HP:0000331)1.85197081
150Increased number of teeth (HP:0011069)1.85005972
151Epistaxis (HP:0000421)1.84759593
152Short foot (HP:0001773)1.84461794
153Thick eyebrow (HP:0000574)1.84163665
154Abnormality of purine metabolism (HP:0004352)1.84097158
155Osteomyelitis (HP:0002754)1.83799190
156Pulmonary embolism (HP:0002204)1.83788949
157Malnutrition (HP:0004395)1.83655632
158Menorrhagia (HP:0000132)1.83225900
159Mitral stenosis (HP:0001718)1.83021814
160Progressive inability to walk (HP:0002505)1.82963166
161Oligodactyly (hands) (HP:0001180)1.81421365
162Clubbing of toes (HP:0100760)1.80221207
163Cardiomegaly (HP:0001640)1.80002937
164Steatorrhea (HP:0002570)1.79553152
165Hypoplastic iliac wings (HP:0002866)1.79403328
166Bulbous nose (HP:0000414)1.79007214
167Absent/shortened dynein arms (HP:0200106)1.78006663
168Dynein arm defect of respiratory motile cilia (HP:0012255)1.78006663
169Conjugated hyperbilirubinemia (HP:0002908)1.77952371
170Hepatocellular carcinoma (HP:0001402)1.77218626
171Focal segmental glomerulosclerosis (HP:0000097)1.77203566
172Tented upper lip vermilion (HP:0010804)1.76937276
173Aplasia/Hypoplasia of the patella (HP:0006498)1.75902018
174Genital tract atresia (HP:0001827)1.74832866
175Stomach cancer (HP:0012126)1.74769955
176Narrow palate (HP:0000189)1.71543747
177Preaxial foot polydactyly (HP:0001841)1.70520868
178Acute lymphatic leukemia (HP:0006721)1.70435400
179Impaired smooth pursuit (HP:0007772)1.69649692
180Nephrogenic diabetes insipidus (HP:0009806)1.69311039
181Exotropia (HP:0000577)1.67152082
182Vaginal atresia (HP:0000148)1.66727640
183Inappropriate behavior (HP:0000719)1.65503829
184Abnormality of incisor morphology (HP:0011063)1.64950494
185Abolished electroretinogram (ERG) (HP:0000550)1.64508800
186Renal cortical cysts (HP:0000803)1.62493617
187Wide intermamillary distance (HP:0006610)1.62398746
188Bony spicule pigmentary retinopathy (HP:0007737)1.59188973
189Intellectual disability, progressive (HP:0006887)1.57709267
190Tracheomalacia (HP:0002779)1.56455954
191Prominent nose (HP:0000448)1.55846486
192Macroorchidism (HP:0000053)1.55521457
193Oligodontia (HP:0000677)1.55283518
194Thyroiditis (HP:0100646)1.55088023
195Lip pit (HP:0100267)1.54658496
196Hyperkalemia (HP:0002153)1.54057701
197Macular degeneration (HP:0000608)1.53636621
198Anencephaly (HP:0002323)1.52768898

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B4.08682936
2ERN13.72277116
3BMPR1B3.16598346
4TRIB32.96415923
5TGFBR22.73726929
6EEF2K2.48617259
7TAOK32.47146185
8TYK22.46238086
9AKT32.37231686
10PKN22.36293617
11MAP4K12.24843410
12FGFR42.12328361
13EPHB12.12325189
14SIK12.10977724
15PTK62.09844104
16STK102.01272992
17CASK1.90340246
18FRK1.84979830
19LRRK21.84682639
20MKNK21.81406115
21ADRBK21.79935958
22RIPK11.78618140
23MAP3K101.76730560
24MST41.74556132
25JAK31.73697150
26TBK11.71614866
27JAK11.67332392
28MST1R1.56653372
29CSF1R1.52352093
30BCKDK1.50183273
31MAP2K31.49533715
32FLT31.47893342
33MAP3K141.41765661
34INSRR1.41604430
35SGK21.39619186
36ZAP701.39405720
37FGFR31.33165953
38BTK1.32256571
39OXSR11.27771583
40GRK11.26345078
41ITK1.24829134
42IRAK31.23275470
43LMTK21.22234988
44CAMK1D1.21982082
45TNIK1.20802040
46BLK1.20469267
47CSK1.19589810
48EPHA21.18508678
49CDK121.18391948
50ADRBK11.17980889
51IKBKE1.16726357
52NEK91.16424860
53KIT1.15769281
54JAK21.13824374
55MELK1.12783223
56WNK31.12336445
57GRK61.10523982
58MAP3K41.09364646
59PIK3CA1.09137137
60CDK61.08881192
61CAMKK21.08739355
62TRPM71.05968320
63MAPK131.05559899
64TTN1.04793196
65MAPKAPK31.03389577
66PIK3CG1.01495180
67STK38L1.00879161
68WNK10.97194464
69NTRK30.94225719
70IRAK40.94097027
71MAP3K30.92918304
72LATS10.91083865
73PAK40.90639561
74MAP3K70.89770173
75IKBKB0.88367189
76SIK20.87733325
77WNK40.86883050
78MAP3K20.86113575
79PAK30.85720108
80MAPK150.85672379
81HCK0.83999006
82SGK30.82434562
83PNCK0.81202190
84SGK4940.80361171
85SGK2230.80361171
86KDR0.78251928
87DAPK20.76603485
88MAP2K20.76012808
89BRD40.75941474
90STK30.75886425
91RPS6KB20.75846938
92LCK0.74244529
93CAMK1G0.72287290
94ZAK0.72002690
95TEC0.70641460
96SYK0.69782742
97EPHA30.68830711
98MAPK110.68016609
99PTK2B0.68000906
100MARK30.67776281
101CHUK0.67248185
102SCYL20.66100619
103MAP3K130.65629995
104STK110.64826647
105IRAK10.64405783
106NUAK10.64120029
107TIE10.63995729
108STK380.63916626
109MET0.63756604
110TLK10.62576255
111TGFBR10.62173629
112MATK0.61554776
113SGK10.61303599
114ERBB20.61118395
115STK390.58031649
116BMX0.57384436
117PDGFRB0.56546027
118PRKCE0.56442700
119STK240.56135321
120PRKAA20.55786364
121CDC42BPA0.55733832
122DMPK0.55277916
123FGFR20.54435706
124RET0.53370432
125RIPK40.53155354
126PTK20.52687168
127PRKG20.52632974
128DYRK1B0.52303289
129PRKCH0.51973521
130CAMK40.51407075
131RPS6KA60.51143516
132FER0.49552984
133MKNK10.49516741
134PRKAA10.49350111
135EGFR0.49199449
136TXK0.48969478
137GSK3A0.47863638
138PDK10.47733327
139CDK90.47159743
140PAK20.47020996
141LYN0.47017961
142PIM10.46771595
143MAP3K80.45922199
144STK40.45173762
145PRKCQ0.44526302
146PDGFRA0.44446527
147PRKD10.44283770
148GRK70.44268713
149PDPK10.43172109
150NLK0.42709938
151MARK20.41917539
152BRSK20.41512478
153PINK10.40120801
154MAPK70.39251587
155CAMK10.37255440
156MAP4K20.37064735
157PKN10.34956715
158ABL10.33249764
159CSNK1D0.32153059
160MTOR0.31437847
161HIPK20.30906472
162MAP2K60.30609798
163PRKCG0.30468484
164MAPK10.28325330
165TNK20.27831057

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.89985125
2Caffeine metabolism_Homo sapiens_hsa002322.65201178
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.53129844
4Staphylococcus aureus infection_Homo sapiens_hsa051502.52902392
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.32447039
6Dorso-ventral axis formation_Homo sapiens_hsa043202.19192064
7Fatty acid degradation_Homo sapiens_hsa000712.18361053
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.05152984
9Linoleic acid metabolism_Homo sapiens_hsa005912.04698659
10Complement and coagulation cascades_Homo sapiens_hsa046102.03669313
11Arginine biosynthesis_Homo sapiens_hsa002201.78069672
12Pentose and glucuronate interconversions_Homo sapiens_hsa000401.77056695
13PPAR signaling pathway_Homo sapiens_hsa033201.76310232
14Tryptophan metabolism_Homo sapiens_hsa003801.73626728
15Histidine metabolism_Homo sapiens_hsa003401.69448215
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68890349
17Ether lipid metabolism_Homo sapiens_hsa005651.65085258
18Fat digestion and absorption_Homo sapiens_hsa049751.57682761
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.53145510
20Other glycan degradation_Homo sapiens_hsa005111.52953921
21Phototransduction_Homo sapiens_hsa047441.48274695
22Fatty acid metabolism_Homo sapiens_hsa012121.47351660
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.44776326
24Nicotine addiction_Homo sapiens_hsa050331.44629384
25ABC transporters_Homo sapiens_hsa020101.44045760
26Sulfur metabolism_Homo sapiens_hsa009201.43798010
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.42545328
28Asthma_Homo sapiens_hsa053101.39330791
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34029103
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.33902375
31Leishmaniasis_Homo sapiens_hsa051401.28926139
32Osteoclast differentiation_Homo sapiens_hsa043801.28769289
33Graft-versus-host disease_Homo sapiens_hsa053321.27935493
34Taste transduction_Homo sapiens_hsa047421.24281110
35Propanoate metabolism_Homo sapiens_hsa006401.23500524
36Lysosome_Homo sapiens_hsa041421.23217826
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22997414
38beta-Alanine metabolism_Homo sapiens_hsa004101.22619865
39Starch and sucrose metabolism_Homo sapiens_hsa005001.20334116
40Peroxisome_Homo sapiens_hsa041461.20176535
41Bile secretion_Homo sapiens_hsa049761.19945635
42Vascular smooth muscle contraction_Homo sapiens_hsa042701.18380542
43B cell receptor signaling pathway_Homo sapiens_hsa046621.18223591
44Chemical carcinogenesis_Homo sapiens_hsa052041.17058592
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12586707
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.12581001
47Primary immunodeficiency_Homo sapiens_hsa053401.12381290
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.11418464
49Glutamatergic synapse_Homo sapiens_hsa047241.09376862
50Morphine addiction_Homo sapiens_hsa050321.08826163
51Vitamin digestion and absorption_Homo sapiens_hsa049771.08509072
52Serotonergic synapse_Homo sapiens_hsa047261.07159066
53Toxoplasmosis_Homo sapiens_hsa051451.06713200
54Ovarian steroidogenesis_Homo sapiens_hsa049131.06701332
55Circadian entrainment_Homo sapiens_hsa047131.05063611
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.02897631
57Circadian rhythm_Homo sapiens_hsa047100.98429576
58Renin-angiotensin system_Homo sapiens_hsa046140.97281367
59Long-term depression_Homo sapiens_hsa047300.97090003
60Antigen processing and presentation_Homo sapiens_hsa046120.96120491
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94019337
62Allograft rejection_Homo sapiens_hsa053300.92982654
63Type II diabetes mellitus_Homo sapiens_hsa049300.92977088
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92746927
65Retinol metabolism_Homo sapiens_hsa008300.92192249
66Calcium signaling pathway_Homo sapiens_hsa040200.92014188
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91201638
68Autoimmune thyroid disease_Homo sapiens_hsa053200.90813416
69Pertussis_Homo sapiens_hsa051330.90623828
70Salivary secretion_Homo sapiens_hsa049700.90539331
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.89438683
72Insulin resistance_Homo sapiens_hsa049310.89297388
73Selenocompound metabolism_Homo sapiens_hsa004500.89022584
74Insulin secretion_Homo sapiens_hsa049110.88746921
75Lysine degradation_Homo sapiens_hsa003100.88700405
76Glycerolipid metabolism_Homo sapiens_hsa005610.88111021
77Olfactory transduction_Homo sapiens_hsa047400.88100309
78Fatty acid biosynthesis_Homo sapiens_hsa000610.87856769
79FoxO signaling pathway_Homo sapiens_hsa040680.87483995
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85478259
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85322151
82Cholinergic synapse_Homo sapiens_hsa047250.84575232
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83402865
84Type I diabetes mellitus_Homo sapiens_hsa049400.83172696
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82750549
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.80617286
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.80560872
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79666775
89Oxytocin signaling pathway_Homo sapiens_hsa049210.79664309
90Renin secretion_Homo sapiens_hsa049240.77998242
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.76419912
92Sphingolipid metabolism_Homo sapiens_hsa006000.75718922
93Measles_Homo sapiens_hsa051620.75424698
94cAMP signaling pathway_Homo sapiens_hsa040240.74100349
95Homologous recombination_Homo sapiens_hsa034400.73565725
96Hepatitis C_Homo sapiens_hsa051600.71961523
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70920218
98Arachidonic acid metabolism_Homo sapiens_hsa005900.69821047
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.69756358
100Phenylalanine metabolism_Homo sapiens_hsa003600.69401277
101Prolactin signaling pathway_Homo sapiens_hsa049170.69069870
102Butanoate metabolism_Homo sapiens_hsa006500.67726576
103Gastric acid secretion_Homo sapiens_hsa049710.67500710
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67357398
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.67160488
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65990938
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64331392
108Chronic myeloid leukemia_Homo sapiens_hsa052200.64324398
109Legionellosis_Homo sapiens_hsa051340.64198610
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.63954118
111Pancreatic secretion_Homo sapiens_hsa049720.63736813
112Platelet activation_Homo sapiens_hsa046110.63617090
113Hematopoietic cell lineage_Homo sapiens_hsa046400.63232082
114Acute myeloid leukemia_Homo sapiens_hsa052210.62684352
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62428792
116Choline metabolism in cancer_Homo sapiens_hsa052310.61508694
117Fanconi anemia pathway_Homo sapiens_hsa034600.61061826
118Tuberculosis_Homo sapiens_hsa051520.60217860
119Pyruvate metabolism_Homo sapiens_hsa006200.59574195
120Influenza A_Homo sapiens_hsa051640.59317867
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58781970
122Amoebiasis_Homo sapiens_hsa051460.58223365
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.57525504
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57488800
125Pancreatic cancer_Homo sapiens_hsa052120.57476246
126MAPK signaling pathway_Homo sapiens_hsa040100.57427529
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57330855
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57218952
129Small cell lung cancer_Homo sapiens_hsa052220.56825197
1302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56724155
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56377226
132GABAergic synapse_Homo sapiens_hsa047270.56277765
133Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55626335
134Folate biosynthesis_Homo sapiens_hsa007900.55437760
135Mineral absorption_Homo sapiens_hsa049780.55318597
136Tyrosine metabolism_Homo sapiens_hsa003500.54951562
137T cell receptor signaling pathway_Homo sapiens_hsa046600.54783091
138Apoptosis_Homo sapiens_hsa042100.53809641
139Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53487157
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53403108
141Dopaminergic synapse_Homo sapiens_hsa047280.53258866
142Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53232314
143Ras signaling pathway_Homo sapiens_hsa040140.52988965
144AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52373727
145TNF signaling pathway_Homo sapiens_hsa046680.52370754
146Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51669902
147Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51499923
148Malaria_Homo sapiens_hsa051440.51109748
149TGF-beta signaling pathway_Homo sapiens_hsa043500.50839755
150Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49955575
151Inositol phosphate metabolism_Homo sapiens_hsa005620.49611743
152Pentose phosphate pathway_Homo sapiens_hsa000300.49469691
153Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48813052
154Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48508836
155Melanoma_Homo sapiens_hsa052180.48336429
156Carbon metabolism_Homo sapiens_hsa012000.48152741
157Cyanoamino acid metabolism_Homo sapiens_hsa004600.48144392
158Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47834498
159Fatty acid elongation_Homo sapiens_hsa000620.47761034
160MicroRNAs in cancer_Homo sapiens_hsa052060.47297187
161NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45235569
162Adherens junction_Homo sapiens_hsa045200.45157078
163Maturity onset diabetes of the young_Homo sapiens_hsa049500.43596048
164Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41000546

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