SFT2D3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.40477853
2DNA deamination (GO:0045006)7.08235497
3viral transcription (GO:0019083)6.43112218
4translational termination (GO:0006415)6.19247404
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.77530073
6cotranslational protein targeting to membrane (GO:0006613)5.72642698
7protein targeting to ER (GO:0045047)5.67011983
8establishment of protein localization to endoplasmic reticulum (GO:0072599)5.46250718
9protein localization to endoplasmic reticulum (GO:0070972)5.41336732
10deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.38552930
11behavioral response to nicotine (GO:0035095)5.34636042
12ribosomal small subunit biogenesis (GO:0042274)5.28836918
13translational elongation (GO:0006414)5.23250433
14platelet dense granule organization (GO:0060155)5.01700203
15viral life cycle (GO:0019058)4.76148470
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.56120346
17cellular protein complex disassembly (GO:0043624)4.54522098
18maturation of SSU-rRNA (GO:0030490)4.35973539
19translational initiation (GO:0006413)4.19791861
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.99845803
21protein complex disassembly (GO:0043241)3.99778258
22protein targeting to membrane (GO:0006612)3.78618991
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.78395586
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.78395586
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.77740355
26mitochondrial respiratory chain complex I assembly (GO:0032981)3.77740355
27NADH dehydrogenase complex assembly (GO:0010257)3.77740355
28macromolecular complex disassembly (GO:0032984)3.77119710
29lymphoid progenitor cell differentiation (GO:0002320)3.72575658
30antigen processing and presentation via MHC class Ib (GO:0002475)3.69720592
31pseudouridine synthesis (GO:0001522)3.60387525
32detection of light stimulus involved in sensory perception (GO:0050962)3.59863746
33detection of light stimulus involved in visual perception (GO:0050908)3.59863746
34nuclear-transcribed mRNA catabolic process (GO:0000956)3.55012385
35respiratory chain complex IV assembly (GO:0008535)3.49814513
36mannosylation (GO:0097502)3.49333552
37positive regulation of cellular amine metabolic process (GO:0033240)3.49084139
38translation (GO:0006412)3.48700985
39nonmotile primary cilium assembly (GO:0035058)3.45279615
40epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.42653408
41water-soluble vitamin biosynthetic process (GO:0042364)3.39104282
42mRNA catabolic process (GO:0006402)3.38864268
43protein complex biogenesis (GO:0070271)3.35345444
44indolalkylamine metabolic process (GO:0006586)3.35289387
45somite development (GO:0061053)3.35159878
46response to interferon-beta (GO:0035456)3.32374534
47GPI anchor biosynthetic process (GO:0006506)3.32066503
48epithelial cilium movement (GO:0003351)3.28947587
49cornea development in camera-type eye (GO:0061303)3.22843349
50detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.21439243
51telomere maintenance via semi-conservative replication (GO:0032201)3.20009941
52axoneme assembly (GO:0035082)3.19881805
53DNA strand elongation involved in DNA replication (GO:0006271)3.18883866
54ribosomal large subunit biogenesis (GO:0042273)3.16028871
55chaperone-mediated protein transport (GO:0072321)3.12529525
56RNA catabolic process (GO:0006401)3.11435332
57negative regulation of erythrocyte differentiation (GO:0045647)3.08176888
58response to pheromone (GO:0019236)3.07904736
59pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.07210168
60negative regulation of telomere maintenance (GO:0032205)3.06350524
61mitochondrial respiratory chain complex assembly (GO:0033108)3.04735824
62pyrimidine nucleobase catabolic process (GO:0006208)3.04585772
63nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.04171047
64exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.02910596
65establishment of integrated proviral latency (GO:0075713)3.00916156
66DNA strand elongation (GO:0022616)3.00316595
67negative regulation of transcription by competitive promoter binding (GO:0010944)2.99624807
68T cell homeostasis (GO:0043029)2.98859965
69negative regulation of transcription regulatory region DNA binding (GO:2000678)2.98140289
70iron-sulfur cluster assembly (GO:0016226)2.97668503
71metallo-sulfur cluster assembly (GO:0031163)2.97668503
72antigen processing and presentation of endogenous antigen (GO:0019883)2.97164584
73GDP-mannose metabolic process (GO:0019673)2.95873910
74C-terminal protein lipidation (GO:0006501)2.94357620
75GPI anchor metabolic process (GO:0006505)2.93412331
76definitive hemopoiesis (GO:0060216)2.91660884
77deoxyribonucleotide catabolic process (GO:0009264)2.90187866
78transmission of nerve impulse (GO:0019226)2.90015408
79positive regulation of B cell differentiation (GO:0045579)2.88822504
80establishment of viral latency (GO:0019043)2.85058740
81signal peptide processing (GO:0006465)2.84306273
82pyrimidine nucleotide catabolic process (GO:0006244)2.83789116
83L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.83718134
84regulation of cilium movement (GO:0003352)2.82802842
85secretory granule organization (GO:0033363)2.82031466
86transcription elongation from RNA polymerase III promoter (GO:0006385)2.80960116
87termination of RNA polymerase III transcription (GO:0006386)2.80960116
88behavioral response to ethanol (GO:0048149)2.80368133
89neural tube formation (GO:0001841)2.80288955
90positive regulation of granulocyte differentiation (GO:0030854)2.79415836
91cilium morphogenesis (GO:0060271)2.78479212
92endosome to pigment granule transport (GO:0043485)2.77750778
93endosome to melanosome transport (GO:0035646)2.77750778
94tryptophan catabolic process (GO:0006569)2.77679921
95indole-containing compound catabolic process (GO:0042436)2.77679921
96indolalkylamine catabolic process (GO:0046218)2.77679921
97transepithelial transport (GO:0070633)2.77349026
98piRNA metabolic process (GO:0034587)2.76864593
99ubiquinone biosynthetic process (GO:0006744)2.76754906
100tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.76700406
101RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.76700406
102kidney morphogenesis (GO:0060993)2.76050159
103nephron epithelium morphogenesis (GO:0072088)2.74940669
104nephron tubule morphogenesis (GO:0072078)2.74940669
105ribonucleoprotein complex biogenesis (GO:0022613)2.74792038
106establishment of protein localization to membrane (GO:0090150)2.74016202
107cell proliferation in forebrain (GO:0021846)2.73945762
108photoreceptor cell maintenance (GO:0045494)2.73042257
109nucleobase catabolic process (GO:0046113)2.72579958
110purine-containing compound salvage (GO:0043101)2.72457074
111G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.72323714
112deoxyribose phosphate catabolic process (GO:0046386)2.71452265
113kynurenine metabolic process (GO:0070189)2.70741478
114protein polyglutamylation (GO:0018095)2.70668019
115cellular component biogenesis (GO:0044085)2.70398766
116cellular ketone body metabolic process (GO:0046950)2.68858639
117pentose metabolic process (GO:0019321)2.67850683
118cilium organization (GO:0044782)2.67795917
119protein targeting (GO:0006605)2.67331335
120proteasome assembly (GO:0043248)2.67282756
121mast cell activation (GO:0045576)2.67241052
122cilium movement (GO:0003341)2.66931818
123protein localization to cilium (GO:0061512)2.66072180
124primary amino compound metabolic process (GO:1901160)2.66045674
125regulation of rhodopsin mediated signaling pathway (GO:0022400)2.65919685
126tRNA modification (GO:0006400)2.65540151
127ubiquinone metabolic process (GO:0006743)2.64228933
128indole-containing compound metabolic process (GO:0042430)2.62835174
129cilium assembly (GO:0042384)2.62766313
130limb bud formation (GO:0060174)2.62042482
131fatty acid elongation (GO:0030497)2.61580681
132rRNA processing (GO:0006364)2.61192889
133purine deoxyribonucleotide catabolic process (GO:0009155)2.61021967
134heme biosynthetic process (GO:0006783)2.60844828
135positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.59771091
136L-fucose catabolic process (GO:0042355)2.59646968
137fucose catabolic process (GO:0019317)2.59646968
138L-fucose metabolic process (GO:0042354)2.59646968
139sulfation (GO:0051923)2.59141110
140retinal ganglion cell axon guidance (GO:0031290)2.57893064
141pentose-phosphate shunt (GO:0006098)2.57450292
142rhodopsin mediated signaling pathway (GO:0016056)2.57322406
143regulation of neurotransmitter uptake (GO:0051580)2.57120636
144DNA replication initiation (GO:0006270)2.56646691
145adenosine metabolic process (GO:0046085)2.55333992
146positive regulation of T cell mediated cytotoxicity (GO:0001916)2.54481453
147dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.53980239
148regulation of mesoderm development (GO:2000380)2.53572629
149viral mRNA export from host cell nucleus (GO:0046784)2.53088004
150ATP synthesis coupled proton transport (GO:0015986)2.51725103
151energy coupled proton transport, down electrochemical gradient (GO:0015985)2.51725103
152intraciliary transport (GO:0042073)2.51703570
153establishment of protein localization to organelle (GO:0072594)2.51555921
154rRNA metabolic process (GO:0016072)2.51030314
155negative regulation of mast cell activation (GO:0033004)2.50532776
156gamma-aminobutyric acid transport (GO:0015812)2.50093827
157startle response (GO:0001964)2.49336068
158cellular response to ATP (GO:0071318)2.49241350
159defense response to protozoan (GO:0042832)2.49236545
160spinal cord motor neuron differentiation (GO:0021522)2.48702055
161cytochrome complex assembly (GO:0017004)2.48280647
162spinal cord development (GO:0021510)2.48062030
163preassembly of GPI anchor in ER membrane (GO:0016254)2.47411744
164ketone body metabolic process (GO:1902224)2.46672351
165photoreceptor cell development (GO:0042461)2.46489616
166embryonic epithelial tube formation (GO:0001838)2.46157220
167tryptophan metabolic process (GO:0006568)2.43395334
168adaptation of signaling pathway (GO:0023058)2.42150984
169neuronal action potential propagation (GO:0019227)2.42141163
170DNA methylation involved in gamete generation (GO:0043046)2.41471990
171negative regulation of cytosolic calcium ion concentration (GO:0051481)2.41261586
172cilium or flagellum-dependent cell motility (GO:0001539)2.41224858
173presynaptic membrane assembly (GO:0097105)2.39628605
174hindbrain development (GO:0030902)2.39570357
175regulation of hexokinase activity (GO:1903299)2.38397243
176regulation of glucokinase activity (GO:0033131)2.38397243
177reflex (GO:0060004)2.36727197
178inositol phosphate catabolic process (GO:0071545)2.35710287
179limb development (GO:0060173)2.32052607
180appendage development (GO:0048736)2.32052607
181cell differentiation in spinal cord (GO:0021515)2.31658804
182regulation of action potential (GO:0098900)2.29640941

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.31750888
2SCL_19346495_ChIP-Seq_HPC-7_Human3.63495538
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.52266184
4EZH2_22144423_ChIP-Seq_EOC_Human3.50086198
5ZNF274_21170338_ChIP-Seq_K562_Hela3.44891066
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.27303942
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.24967833
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.18001767
9VDR_22108803_ChIP-Seq_LS180_Human3.14032585
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.12301468
11* TAL1_20887958_ChIP-Seq_HPC-7_Mouse3.10154638
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse3.09584866
13ELF1_17652178_ChIP-ChIP_JURKAT_Human3.01061817
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.99963281
15GBX2_23144817_ChIP-Seq_PC3_Human2.94214125
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.85473894
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.84000414
18FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.79854167
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.76986080
20ERG_20887958_ChIP-Seq_HPC-7_Mouse2.73392413
21E2F7_22180533_ChIP-Seq_HELA_Human2.64962022
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.64873293
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.61699622
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.57196843
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.57032767
26GATA1_22025678_ChIP-Seq_K562_Human2.55315966
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.52930415
28IGF1R_20145208_ChIP-Seq_DFB_Human2.45589509
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.41678232
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.40495247
31* VDR_23849224_ChIP-Seq_CD4+_Human2.39417265
32FUS_26573619_Chip-Seq_HEK293_Human2.33985312
33EWS_26573619_Chip-Seq_HEK293_Human2.31974054
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.29181476
35VDR_21846776_ChIP-Seq_THP-1_Human2.28477702
36FOXP3_21729870_ChIP-Seq_TREG_Human2.28167634
37POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23761990
38SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.22939087
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.20064654
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.18688202
41CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16189846
42XRN2_22483619_ChIP-Seq_HELA_Human2.13607714
43HOXB4_20404135_ChIP-ChIP_EML_Mouse2.11346499
44SRF_21415370_ChIP-Seq_HL-1_Mouse2.09206084
45LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.05911801
46NOTCH1_21737748_ChIP-Seq_TLL_Human2.05895537
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.05219879
48CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02291887
49P300_19829295_ChIP-Seq_ESCs_Human2.02241271
50MYC_19030024_ChIP-ChIP_MESCs_Mouse2.00978813
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.99186596
52* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.92344246
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.90988704
54CREB1_15753290_ChIP-ChIP_HEK293T_Human1.90681869
55* SPI1_23547873_ChIP-Seq_NB4_Human1.87953111
56* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.85211006
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.84880859
58CIITA_25753668_ChIP-Seq_RAJI_Human1.84669379
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83168152
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.79988700
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78914789
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.77494812
63TAF15_26573619_Chip-Seq_HEK293_Human1.76885039
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74581805
65GATA1_22383799_ChIP-Seq_G1ME_Mouse1.74314167
66* MYC_22102868_ChIP-Seq_BL_Human1.73784265
67ER_23166858_ChIP-Seq_MCF-7_Human1.72612217
68DCP1A_22483619_ChIP-Seq_HELA_Human1.71807620
69MYB_21317192_ChIP-Seq_ERMYB_Mouse1.69430463
70* VDR_24763502_ChIP-Seq_THP-1_Human1.67839387
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.67643974
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66405013
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.65454130
74IRF8_22096565_ChIP-ChIP_GC-B_Human1.64481519
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.64023574
76* GABP_19822575_ChIP-Seq_HepG2_Human1.62669247
77RNF2_27304074_Chip-Seq_NSC_Mouse1.60309656
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59551437
79MYC_19079543_ChIP-ChIP_MESCs_Mouse1.59479907
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.58333564
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58285880
82TTF2_22483619_ChIP-Seq_HELA_Human1.57938403
83TP53_22573176_ChIP-Seq_HFKS_Human1.56138269
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.55998885
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.55793681
86NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55156439
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54716507
88CBP_20019798_ChIP-Seq_JUKART_Human1.54608758
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54608758
90PIAS1_25552417_ChIP-Seq_VCAP_Human1.54103602
91ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54065001
92NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54009011
93IRF1_19129219_ChIP-ChIP_H3396_Human1.53628911
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49848384
95TP63_19390658_ChIP-ChIP_HaCaT_Human1.45498717
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44711329
97YY1_21170310_ChIP-Seq_MESCs_Mouse1.43645461
98REST_21632747_ChIP-Seq_MESCs_Mouse1.42357432
99PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42302626
100STAT4_19710469_ChIP-ChIP_TH1__Mouse1.41787508
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39812837
102STAT3_23295773_ChIP-Seq_U87_Human1.38311347
103SMAD4_21799915_ChIP-Seq_A2780_Human1.38290814
104FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38143481
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37388130
106EZH2_27304074_Chip-Seq_ESCs_Mouse1.37157835
107BCAT_22108803_ChIP-Seq_LS180_Human1.37153479
108CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.37146076
109RUNX1_22412390_ChIP-Seq_EML_Mouse1.37101693
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34789663
111ELK1_19687146_ChIP-ChIP_HELA_Human1.34681785
112AR_25329375_ChIP-Seq_VCAP_Human1.34625520
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34354533
114MYB_26560356_Chip-Seq_TH2_Human1.34067172
115SMAD3_21741376_ChIP-Seq_EPCs_Human1.33493609
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31456843
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31456843
118TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30701039
119JARID2_20064375_ChIP-Seq_MESCs_Mouse1.29446050
120ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27581924
121EED_16625203_ChIP-ChIP_MESCs_Mouse1.26764491
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.26596737
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26464549
124TCF4_23295773_ChIP-Seq_U87_Human1.26169541
125GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25669136
126ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25317749
127MAF_26560356_Chip-Seq_TH1_Human1.24375000
128E2F4_17652178_ChIP-ChIP_JURKAT_Human1.23808501
129NANOG_19829295_ChIP-Seq_ESCs_Human1.22767207
130SOX2_19829295_ChIP-Seq_ESCs_Human1.22767207
131GATA3_21878914_ChIP-Seq_MCF-7_Human1.21417434
132TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20649470
133TCF4_22108803_ChIP-Seq_LS180_Human1.20468669
134SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19881669
135* NCOR_22424771_ChIP-Seq_293T_Human1.19332722
136* UTX_26944678_Chip-Seq_JUKART_Human1.19135968
137SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16579752
138RUNX2_22187159_ChIP-Seq_PCA_Human1.15575162
139PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15554119
140* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15044274
141MYB_26560356_Chip-Seq_TH1_Human1.12650410
142SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12488162
143ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11601294
144ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11115980
145POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10742321
146* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09898692
147CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09418765
148EZH2_27294783_Chip-Seq_ESCs_Mouse1.08745113
149CTCF_18555785_ChIP-Seq_MESCs_Mouse1.08567851
150* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08348872
151MAF_26560356_Chip-Seq_TH2_Human1.07566877
152MYC_18940864_ChIP-ChIP_HL60_Human1.07514049
153FLI1_21867929_ChIP-Seq_TH2_Mouse1.07201827
154EZH2_27294783_Chip-Seq_NPCs_Mouse1.06822382
155FOXA1_25329375_ChIP-Seq_VCAP_Human1.06215840
156FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06215840
157E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06160880
158SMAD4_21741376_ChIP-Seq_EPCs_Human1.06085802
159* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05305673
160E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04762675
161NFE2_27457419_Chip-Seq_LIVER_Mouse1.04142230
162JARID2_20075857_ChIP-Seq_MESCs_Mouse1.04028495
163GATA1_19941827_ChIP-Seq_MEL_Mouse1.02457941
164OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01513270
165KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99725882
166HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99576263
167FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.98336309
168TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98253168
169SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.98153500
170BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98097492
171REST_18959480_ChIP-ChIP_MESCs_Mouse0.98057317
172CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97639525
173CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96285652
174MYCN_18555785_ChIP-Seq_MESCs_Mouse0.96238849
175YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96102422
176EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96018897
177ETS1_22383799_ChIP-Seq_G1ME_Mouse0.95964752
178HTT_18923047_ChIP-ChIP_STHdh_Human0.95946315
179NANOG_18555785_Chip-Seq_ESCs_Mouse0.95878537
180PRDM14_20953172_ChIP-Seq_ESCs_Human0.95869184
181TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95437951
182FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95121352
183SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94587921
184DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94032061
185MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92370989
186BRD4_27068464_Chip-Seq_AML-cells_Mouse0.91315007
187NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91016612
188SRY_22984422_ChIP-ChIP_TESTIS_Rat0.90014740
189PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88700334
190NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88642624
191KDM5A_27292631_Chip-Seq_BREAST_Human0.88271880

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.79918256
2MP0005075_abnormal_melanosome_morpholog3.34401397
3MP0009379_abnormal_foot_pigmentation3.29063740
4MP0004147_increased_porphyrin_level3.13649209
5MP0005174_abnormal_tail_pigmentation2.93991050
6MP0003136_yellow_coat_color2.68398701
7MP0005671_abnormal_response_to2.59339460
8MP0000465_gastrointestinal_hemorrhage2.59010834
9MP0001835_abnormal_antigen_presentation2.51982488
10MP0005646_abnormal_pituitary_gland2.42949148
11MP0002095_abnormal_skin_pigmentation2.36395351
12MP0000685_abnormal_immune_system2.35195866
13MP0003195_calcinosis2.33738779
14MP0009785_altered_susceptibility_to2.30388333
15MP0001968_abnormal_touch/_nociception2.28353402
16MP0003724_increased_susceptibility_to2.25280955
17MP0005551_abnormal_eye_electrophysiolog2.24522717
18MP0002653_abnormal_ependyma_morphology2.20783806
19MP0002102_abnormal_ear_morphology2.20469678
20MP0001986_abnormal_taste_sensitivity2.16368190
21MP0006054_spinal_hemorrhage2.14696354
22MP0005397_hematopoietic_system_phenotyp2.13098360
23MP0001545_abnormal_hematopoietic_system2.13098360
24MP0003763_abnormal_thymus_physiology2.12021260
25MP0002837_dystrophic_cardiac_calcinosis2.11793755
26MP0002138_abnormal_hepatobiliary_system2.06785218
27MP0002398_abnormal_bone_marrow2.03328457
28MP0000569_abnormal_digit_pigmentation2.02768621
29MP0008877_abnormal_DNA_methylation2.02368289
30MP0005025_abnormal_response_to2.01317442
31MP0001873_stomach_inflammation1.99011199
32MP0003656_abnormal_erythrocyte_physiolo1.94546883
33MP0003880_abnormal_central_pattern1.92009326
34MP0002736_abnormal_nociception_after1.91206158
35MP0004808_abnormal_hematopoietic_stem1.90241838
36MP0004885_abnormal_endolymph1.89593594
37MP0006036_abnormal_mitochondrial_physio1.89318606
38MP0008872_abnormal_physiological_respon1.86996351
39MP0006292_abnormal_olfactory_placode1.86252743
40MP0009333_abnormal_splenocyte_physiolog1.85182919
41MP0003787_abnormal_imprinting1.84414071
42MP0002876_abnormal_thyroid_physiology1.83884520
43MP0002420_abnormal_adaptive_immunity1.81044468
44MP0008789_abnormal_olfactory_epithelium1.76880259
45MP0000920_abnormal_myelination1.75916540
46MP0001819_abnormal_immune_cell1.75085861
47MP0000490_abnormal_crypts_of1.73772211
48MP0000689_abnormal_spleen_morphology1.73112107
49MP0000716_abnormal_immune_system1.73007841
50MP0005409_darkened_coat_color1.72711161
51MP0002723_abnormal_immune_serum1.72275087
52MP0005000_abnormal_immune_tolerance1.69518395
53MP0006276_abnormal_autonomic_nervous1.68045783
54MP0002722_abnormal_immune_system1.67969833
55MP0003283_abnormal_digestive_organ1.67424720
56MP0002429_abnormal_blood_cell1.67279883
57MP0002166_altered_tumor_susceptibility1.66108468
58MP0001800_abnormal_humoral_immune1.65481657
59MP0003806_abnormal_nucleotide_metabolis1.63081073
60MP0002163_abnormal_gland_morphology1.63008351
61MP0005253_abnormal_eye_physiology1.62630823
62MP0001529_abnormal_vocalization1.62219861
63MP0000372_irregular_coat_pigmentation1.62030514
64MP0004043_abnormal_pH_regulation1.56831008
65MP0009745_abnormal_behavioral_response1.55924055
66MP0005645_abnormal_hypothalamus_physiol1.55751670
67MP0005464_abnormal_platelet_physiology1.53903455
68MP0002452_abnormal_antigen_presenting1.51405334
69MP0003866_abnormal_defecation1.49994076
70MP0002234_abnormal_pharynx_morphology1.49803186
71MP0002272_abnormal_nervous_system1.49680039
72MP0005379_endocrine/exocrine_gland_phen1.46859693
73MP0003122_maternal_imprinting1.46011010
74MP0008058_abnormal_DNA_repair1.43746697
75MP0001905_abnormal_dopamine_level1.43695777
76MP0002419_abnormal_innate_immunity1.42907285
77MP0004145_abnormal_muscle_electrophysio1.42192604
78MP0005171_absent_coat_pigmentation1.40764872
79MP0005394_taste/olfaction_phenotype1.40085058
80MP0005499_abnormal_olfactory_system1.40085058
81MP0000778_abnormal_nervous_system1.39329486
82MP0004133_heterotaxia1.38661765
83MP0002735_abnormal_chemical_nociception1.37441974
84MP0002148_abnormal_hypersensitivity_rea1.36112258
85MP0001486_abnormal_startle_reflex1.32552917
86MP0000703_abnormal_thymus_morphology1.32450437
87MP0003868_abnormal_feces_composition1.32288370
88MP0002160_abnormal_reproductive_system1.31653505
89MP0002938_white_spotting1.29290298
90MP0003646_muscle_fatigue1.29211612
91MP0009046_muscle_twitch1.28501120
92MP0002277_abnormal_respiratory_mucosa1.28129947
93MP0010386_abnormal_urinary_bladder1.27794714
94MP0004381_abnormal_hair_follicle1.27302659
95MP0001485_abnormal_pinna_reflex1.26870757
96MP0003436_decreased_susceptibility_to1.25523785
97MP0002572_abnormal_emotion/affect_behav1.22936654
98MP0002557_abnormal_social/conspecific_i1.22835447
99MP0002132_abnormal_respiratory_system1.19830168
100MP0003121_genomic_imprinting1.16932492
101MP0000427_abnormal_hair_cycle1.15910483
102MP0003186_abnormal_redox_activity1.15014049
103MP0002933_joint_inflammation1.14440941
104MP0001970_abnormal_pain_threshold1.12521428
105MP0001984_abnormal_olfaction1.12440349
106MP0008875_abnormal_xenobiotic_pharmacok1.11763096
107MP0010094_abnormal_chromosome_stability1.11602564
108MP0003011_delayed_dark_adaptation1.10666326
109MP0002909_abnormal_adrenal_gland1.10226660
110MP0005195_abnormal_posterior_eye1.08779913
111MP0004957_abnormal_blastocyst_morpholog1.08409876
112MP0002064_seizures1.08315301
113MP0002734_abnormal_mechanical_nocicepti1.07188617
114MP0005389_reproductive_system_phenotype1.07040744
115MP0000015_abnormal_ear_pigmentation1.06554751
116MP0004924_abnormal_behavior1.06379708
117MP0005386_behavior/neurological_phenoty1.06379708
118MP0000516_abnormal_urinary_system1.06371078
119MP0005367_renal/urinary_system_phenotyp1.06371078
120MP0005387_immune_system_phenotype1.06297833
121MP0001790_abnormal_immune_system1.06297833
122MP0002733_abnormal_thermal_nociception1.05759977
123MP0001853_heart_inflammation1.05630407
124MP0008469_abnormal_protein_level1.05399857
125MP0000049_abnormal_middle_ear1.02376121
126MP0003183_abnormal_peptide_metabolism1.00999084
127MP0001293_anophthalmia1.00969029
128MP0002751_abnormal_autonomic_nervous1.00615442
129MP0006035_abnormal_mitochondrial_morpho0.99837674
130MP0000631_abnormal_neuroendocrine_gland0.99615391
131MP0005410_abnormal_fertilization0.98655739
132MP0003943_abnormal_hepatobiliary_system0.98037173
133MP0005220_abnormal_exocrine_pancreas0.97926834
134MP0000026_abnormal_inner_ear0.97888610
135MP0002752_abnormal_somatic_nervous0.97796655
136MP0002067_abnormal_sensory_capabilities0.97444888
137MP0002063_abnormal_learning/memory/cond0.96364119
138MP0001501_abnormal_sleep_pattern0.95904782
139MP0000313_abnormal_cell_death0.95533892
140MP0003567_abnormal_fetal_cardiomyocyte0.94183906
141MP0003119_abnormal_digestive_system0.92755781
142MP0009765_abnormal_xenobiotic_induced0.91967829
143MP0003635_abnormal_synaptic_transmissio0.91830787
144MP0002822_catalepsy0.91677194
145MP0005636_abnormal_mineral_homeostasis0.91514426
146MP0010155_abnormal_intestine_physiology0.90825187
147MP0002019_abnormal_tumor_incidence0.90807111
148MP0001324_abnormal_eye_pigmentation0.90761855
149MP0001845_abnormal_inflammatory_respons0.90126371
150MP0001963_abnormal_hearing_physiology0.89566307
151MP0003252_abnormal_bile_duct0.89181909
152MP0003693_abnormal_embryo_hatching0.88413811
153MP0005084_abnormal_gallbladder_morpholo0.86126023
154MP0004142_abnormal_muscle_tone0.85398115
155MP0005584_abnormal_enzyme/coenzyme_acti0.85366257
156MP0002233_abnormal_nose_morphology0.85056655
157MP0001944_abnormal_pancreas_morphology0.84728577
158MP0002184_abnormal_innervation0.82688336
159MP0008007_abnormal_cellular_replicative0.82598094
160MP0000230_abnormal_systemic_arterial0.82544474
161MP0001663_abnormal_digestive_system0.82124161
162MP0003077_abnormal_cell_cycle0.80945257
163MP0002638_abnormal_pupillary_reflex0.79256673
164MP0008057_abnormal_DNA_replication0.78227117
165MP0000681_abnormal_thyroid_gland0.77687247
166MP0002928_abnormal_bile_duct0.76650923
167MP0002210_abnormal_sex_determination0.76592734
168MP0003938_abnormal_ear_development0.76394445
169MP0001919_abnormal_reproductive_system0.75456693
170MP0005391_vision/eye_phenotype0.75303080
171MP0002405_respiratory_system_inflammati0.74927881
172MP0002006_tumorigenesis0.74800602
173MP0002693_abnormal_pancreas_physiology0.73662534
174MP0000613_abnormal_salivary_gland0.73406434
175MP0002075_abnormal_coat/hair_pigmentati0.71543466
176MP0003172_abnormal_lysosome_physiology0.69724415
177MP0003638_abnormal_response/metabolism_0.67890557
178MP0005058_abnormal_lysosome_morphology0.67821057
179MP0001348_abnormal_lacrimal_gland0.67341341
180MP0005381_digestive/alimentary_phenotyp0.66501521
181MP0008995_early_reproductive_senescence0.60593955
182MP0006072_abnormal_retinal_apoptosis0.59889567

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)5.95242484
2Abnormality of cells of the erythroid lineage (HP:0012130)5.94036243
3Aplastic anemia (HP:0001915)5.09641820
4Abnormality of the heme biosynthetic pathway (HP:0010472)4.85677956
5Pancreatic cysts (HP:0001737)4.49471557
6Reticulocytopenia (HP:0001896)4.36592176
7Reduced antithrombin III activity (HP:0001976)4.34190106
8Type I transferrin isoform profile (HP:0003642)4.29415169
9Elevated erythrocyte sedimentation rate (HP:0003565)4.01501380
10Pancreatic fibrosis (HP:0100732)4.01065726
11Hepatocellular necrosis (HP:0001404)3.95260280
12Pallor (HP:0000980)3.95042031
13Decreased activity of mitochondrial respiratory chain (HP:0008972)3.93967302
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.93967302
15Thrombocytosis (HP:0001894)3.86383259
16Abnormality of midbrain morphology (HP:0002418)3.85639652
17Molar tooth sign on MRI (HP:0002419)3.85639652
18Abnormal protein glycosylation (HP:0012346)3.83102820
19Abnormal glycosylation (HP:0012345)3.83102820
20Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.83102820
21Abnormal protein N-linked glycosylation (HP:0012347)3.83102820
22True hermaphroditism (HP:0010459)3.80110609
23Renal Fanconi syndrome (HP:0001994)3.79505569
24Congenital stationary night blindness (HP:0007642)3.66881046
25Hepatic necrosis (HP:0002605)3.58253627
26Chronic otitis media (HP:0000389)3.52418717
27Increased hepatocellular lipid droplets (HP:0006565)3.50095917
28Macrocytic anemia (HP:0001972)3.46689325
29Increased intramyocellular lipid droplets (HP:0012240)3.37222049
30IgM deficiency (HP:0002850)3.32933122
31Nephronophthisis (HP:0000090)3.30982183
32Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.28620145
33Type II lissencephaly (HP:0007260)3.22789053
34Absent rod-and cone-mediated responses on ERG (HP:0007688)3.20162343
35Lipid accumulation in hepatocytes (HP:0006561)3.19972604
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.11382950
37Mitochondrial inheritance (HP:0001427)3.10722173
38Abnormality of the renal cortex (HP:0011035)3.07278850
39Petechiae (HP:0000967)3.05883136
40Medial flaring of the eyebrow (HP:0010747)3.04796139
413-Methylglutaconic aciduria (HP:0003535)3.02693553
42Abnormality of the renal medulla (HP:0100957)3.02661099
43Increased muscle lipid content (HP:0009058)3.00639876
44Cystic liver disease (HP:0006706)2.99746406
45Exertional dyspnea (HP:0002875)2.98646756
46Attenuation of retinal blood vessels (HP:0007843)2.80166899
47Chronic hepatic failure (HP:0100626)2.67746052
48Panhypogammaglobulinemia (HP:0003139)2.66406393
49Hyperventilation (HP:0002883)2.64982084
50Microvesicular hepatic steatosis (HP:0001414)2.61181414
51Increased serum lactate (HP:0002151)2.59968186
52Prolonged bleeding time (HP:0003010)2.59100388
53Pendular nystagmus (HP:0012043)2.57061167
54Increased CSF lactate (HP:0002490)2.56304566
55Hypothermia (HP:0002045)2.51985048
56Sclerocornea (HP:0000647)2.50839037
57Decreased central vision (HP:0007663)2.44353500
58Septo-optic dysplasia (HP:0100842)2.43815346
59Optic nerve hypoplasia (HP:0000609)2.43568737
60Severe visual impairment (HP:0001141)2.42730174
61Gait imbalance (HP:0002141)2.39732059
62Thyroid-stimulating hormone excess (HP:0002925)2.39196835
63Hypoplasia of the thymus (HP:0000778)2.37966312
64Abnormal drinking behavior (HP:0030082)2.37692588
65Polydipsia (HP:0001959)2.37692588
66Rib fusion (HP:0000902)2.37124971
67Generalized aminoaciduria (HP:0002909)2.36644273
68Pancytopenia (HP:0001876)2.36301149
69Lactic acidosis (HP:0003128)2.36082233
70Microcytic anemia (HP:0001935)2.35348847
71Abnormal mitochondria in muscle tissue (HP:0008316)2.33867959
72Ragged-red muscle fibers (HP:0003200)2.33710635
73Decreased electroretinogram (ERG) amplitude (HP:0000654)2.32474283
74Congenital primary aphakia (HP:0007707)2.32104265
75Tubular atrophy (HP:0000092)2.31997206
76Cerebellar dysplasia (HP:0007033)2.31763786
77Focal motor seizures (HP:0011153)2.31470789
78Renal cortical cysts (HP:0000803)2.31016751
79Abolished electroretinogram (ERG) (HP:0000550)2.29297921
80Aplasia/Hypoplasia of the tibia (HP:0005772)2.29006449
81Acute necrotizing encephalopathy (HP:0006965)2.28632720
82Asplenia (HP:0001746)2.27897513
83Nephrogenic diabetes insipidus (HP:0009806)2.24956093
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.24857778
85Abnormality of alanine metabolism (HP:0010916)2.24857778
86Hyperalaninemia (HP:0003348)2.24857778
87Abnormality of the labia minora (HP:0012880)2.24337468
88Polyuria (HP:0000103)2.22411166
89Keratoconus (HP:0000563)2.21881617
90Increased corneal curvature (HP:0100692)2.21881617
91Congenital hepatic fibrosis (HP:0002612)2.19202140
92B lymphocytopenia (HP:0010976)2.18454624
93Abnormality of B cell number (HP:0010975)2.18454624
94Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.17969717
95Abnormality of T cell physiology (HP:0011840)2.17060188
96Abnormality of DNA repair (HP:0003254)2.16770209
97Abnormal rod and cone electroretinograms (HP:0008323)2.14045909
98Epistaxis (HP:0000421)2.13902805
99Bony spicule pigmentary retinopathy (HP:0007737)2.13799874
100Genital tract atresia (HP:0001827)2.13666381
101Agitation (HP:0000713)2.11527465
102Lissencephaly (HP:0001339)2.10567865
103Abnormality of aromatic amino acid family metabolism (HP:0004338)2.09574852
104Recurrent bronchitis (HP:0002837)2.09443882
105Microretrognathia (HP:0000308)2.07696678
106Type 2 muscle fiber atrophy (HP:0003554)2.07053933
107Nonprogressive disorder (HP:0003680)2.06793469
108Anencephaly (HP:0002323)2.05895921
109Male pseudohermaphroditism (HP:0000037)2.05605291
110Vaginal atresia (HP:0000148)2.05572403
111Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.05563573
112Aplasia/Hypoplasia of the tongue (HP:0010295)2.05430421
113Increased serum ferritin (HP:0003281)2.05360175
114Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.03852085
115Aplasia/hypoplasia of the uterus (HP:0008684)2.02316325
116Abnormality of renal resorption (HP:0011038)2.01530852
117Chorioretinal atrophy (HP:0000533)2.00811309
118Progressive neurologic deterioration (HP:0002344)2.00559242
119Abnormal delayed hypersensitivity skin test (HP:0002963)1.99927796
120Respiratory difficulties (HP:0002880)1.99278643
121Intestinal atresia (HP:0011100)1.99160218
122Neutropenia (HP:0001875)1.98745217
123Broad-based gait (HP:0002136)1.97677899
124Myositis (HP:0100614)1.97388227
125Progressive macrocephaly (HP:0004481)1.97335411
126Recurrent viral infections (HP:0004429)1.97330167
127Cerebral hypomyelination (HP:0006808)1.97080221
128Acute encephalopathy (HP:0006846)1.96818812
129Hemiparesis (HP:0001269)1.96282226
130Hypoplasia of the uterus (HP:0000013)1.96014622
131Agammaglobulinemia (HP:0004432)1.94435835
132Short tibia (HP:0005736)1.93939545
133Hyperglycinemia (HP:0002154)1.93792877
134Large for gestational age (HP:0001520)1.92603463
135Hypoproteinemia (HP:0003075)1.92354571
136Purpura (HP:0000979)1.92292622
137Muscle fiber atrophy (HP:0100295)1.92200377
138Aplasia/Hypoplasia of the spleen (HP:0010451)1.91516294
139Methylmalonic acidemia (HP:0002912)1.90726166
140Methylmalonic aciduria (HP:0012120)1.90156093
141Gaze-evoked nystagmus (HP:0000640)1.89861285
142Abnormality of the nasal septum (HP:0000419)1.89222054
143Abnormality of the columella (HP:0009929)1.87544193
144Broad face (HP:0000283)1.86829917
145Furrowed tongue (HP:0000221)1.85971880
146Progressive cerebellar ataxia (HP:0002073)1.85575178
147Exercise intolerance (HP:0003546)1.84624918
148Absent speech (HP:0001344)1.84186839
149Poikiloderma (HP:0001029)1.83513997
150Spastic paraparesis (HP:0002313)1.83286144
151Enlarged kidneys (HP:0000105)1.82988649
152Hyperphosphaturia (HP:0003109)1.82778141
153Gastrointestinal stroma tumor (HP:0100723)1.82308148
154Anophthalmia (HP:0000528)1.82160616
155Small hand (HP:0200055)1.81502496
156Congenital sensorineural hearing impairment (HP:0008527)1.80600145
157Concave nail (HP:0001598)1.80237860
158Thoracic kyphosis (HP:0002942)1.79896114
159Erythema (HP:0010783)1.79108634
160Focal seizures (HP:0007359)1.78758611
161Postaxial foot polydactyly (HP:0001830)1.78737299
162Pachygyria (HP:0001302)1.78721314
163Increased neuronal autofluorescent lipopigment (HP:0002074)1.78270665
164Postaxial hand polydactyly (HP:0001162)1.77949534
165Respiratory failure (HP:0002878)1.77650175
166Optic disc pallor (HP:0000543)1.77368273
167Brushfield spots (HP:0001088)1.76880810
168Congenital, generalized hypertrichosis (HP:0004540)1.76859876
169Aplasia/Hypoplasia of the sacrum (HP:0008517)1.76425542
170Progressive inability to walk (HP:0002505)1.76197597
171Abnormal urine output (HP:0012590)1.74847445
172Bile duct proliferation (HP:0001408)1.74651871
173Abnormal biliary tract physiology (HP:0012439)1.74651871
174Ketosis (HP:0001946)1.74410935
175Poor coordination (HP:0002370)1.73549271
176Abnormality of dicarboxylic acid metabolism (HP:0010995)1.70781829
177Dicarboxylic aciduria (HP:0003215)1.70781829
178Febrile seizures (HP:0002373)1.68701163
179Retinal dysplasia (HP:0007973)1.68494708
180Gastrointestinal inflammation (HP:0004386)1.65413539
181Colon cancer (HP:0003003)1.64771840

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK6.03455003
2FRK4.85144335
3STK164.61867039
4CDK193.76199989
5KIT2.89764371
6WNK32.66038629
7NME22.63224520
8FLT32.59434363
9NUAK12.46893490
10CASK2.45971871
11MUSK2.43168139
12PIM22.38376069
13ZAK2.30023079
14GRK12.25156491
15MAP4K22.22641568
16DYRK32.22396257
17ACVR1B2.19550817
18WNK42.06962032
19KDR2.01035088
20LMTK21.94772682
21BCKDK1.89325389
22EIF2AK31.85778971
23TESK21.84746236
24TEC1.84447790
25PINK11.81888310
26MAP4K11.79968168
27MAP3K41.76492703
28NLK1.75489220
29WEE11.74100666
30BTK1.71500525
31INSRR1.69579393
32MAP2K71.68845485
33VRK21.64031230
34MAPKAPK51.63023244
35TLK11.61984365
36TRIM281.49203028
37TGFBR11.44034525
38CAMKK21.38883395
39VRK11.38040237
40MKNK11.36726691
41TBK11.35478032
42TIE11.33884405
43MARK11.30928144
44FES1.30760461
45CSF1R1.29236331
46PAK31.27684358
47PNCK1.18688678
48EPHA41.16661653
49TXK1.13820306
50IRAK41.13799266
51CSNK1G31.13581501
52ADRBK11.07914907
53PRKCG1.07518233
54BLK1.07254259
55SYK1.04966071
56STK38L1.04624461
57ZAP701.02917935
58SCYL21.02808625
59NTRK31.01518352
60STK391.00427070
61SRPK11.00173122
62TAF10.99829695
63PRKCE0.97625461
64MAP3K120.97568651
65FGFR20.96777410
66IKBKE0.95719096
67PIK3CA0.95224408
68LRRK20.94379202
69MKNK20.93475588
70MAPK150.92714187
71RPS6KB20.91645860
72TGFBR20.88852606
73EEF2K0.88487764
74PLK20.88459058
75TAOK30.86637081
76DAPK20.86082251
77OXSR10.85468732
78HIPK20.83830932
79BMPR1B0.83591292
80BRSK20.83589058
81EPHB20.83391892
82LYN0.82360259
83RAF10.82322299
84CLK10.82289343
85CSNK1G10.81432411
86CAMK10.80354307
87BCR0.77989675
88SIK30.77310107
89CSNK1A1L0.75692191
90NTRK20.75073068
91MATK0.73728036
92PASK0.72936361
93EPHB10.70382845
94MAP2K30.70222091
95JAK30.69478589
96UHMK10.68920763
97CDK70.67493682
98PIM10.67082641
99PLK30.66290821
100STK110.66143494
101LCK0.64783530
102ERN10.63982715
103ERBB30.63767590
104IRAK10.63314204
105CDK80.62660109
106PHKG10.59351486
107PHKG20.59351486
108IKBKB0.59348085
109BRD40.57841857
110MAPK40.57625731
111CSNK1A10.57177723
112MAP3K60.56722412
113PRKACA0.55497309
114CSNK1G20.54206703
115CAMK2A0.53940217
116STK30.53933551
117ILK0.50773296
118GRK50.50468902
119CDC70.50073188
120BUB10.49639565
121RPS6KA50.48996643
122DYRK20.48824090
123GRK70.47685224
124MAP3K70.45642663
125ERBB20.44612652
126ARAF0.43352074
127ITK0.43059772
128PRKCH0.42857470
129MARK20.42474955
130CDK40.41073308
131MAPK130.41064426
132CDK30.38590705
133PRKCZ0.37318870
134DYRK1A0.36174950
135ADRBK20.36058380
136PRKCA0.35614086
137IRAK20.35480867
138PRKG20.35137341
139CSNK1D0.34590458
140PRKD20.33992401
141DAPK10.33904519
142SGK20.33461193
143EIF2AK20.33260437
144PDK20.32919137
145CSNK2A20.32538303
146PKN10.32493490
147MAP2K20.32480743
148NEK20.32478341
149CAMK2D0.32164789
150ATR0.31641391
151PIK3CG0.31412183
152ATM0.30571441
153PRKCI0.30491616
154MAPKAPK30.30204294
155SGK2230.30155929
156SGK4940.30155929
157MAPK110.29858758
158PRKACB0.29552332
159GRK60.29396091
160DYRK1B0.28131485
161PRKCQ0.27200000
162TYK20.26546173
163CCNB10.24647544

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.75240604
2DNA replication_Homo sapiens_hsa030303.81991039
3Protein export_Homo sapiens_hsa030603.65084976
4Phototransduction_Homo sapiens_hsa047442.76051611
5RNA polymerase_Homo sapiens_hsa030202.52125471
6Proteasome_Homo sapiens_hsa030502.51089292
7Folate biosynthesis_Homo sapiens_hsa007902.48271313
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.42953095
9Pyrimidine metabolism_Homo sapiens_hsa002402.36018626
10Mismatch repair_Homo sapiens_hsa034302.28504037
11Spliceosome_Homo sapiens_hsa030402.27598797
12Nitrogen metabolism_Homo sapiens_hsa009102.27371464
13Sulfur relay system_Homo sapiens_hsa041222.26254172
14Base excision repair_Homo sapiens_hsa034102.17703884
15N-Glycan biosynthesis_Homo sapiens_hsa005102.17234057
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.14207645
17Butanoate metabolism_Homo sapiens_hsa006502.13924649
18Nicotine addiction_Homo sapiens_hsa050332.13048379
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.09553060
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.09233539
21Homologous recombination_Homo sapiens_hsa034402.00220612
22Fatty acid elongation_Homo sapiens_hsa000621.98669789
23Non-homologous end-joining_Homo sapiens_hsa034501.93552009
24Primary immunodeficiency_Homo sapiens_hsa053401.92931767
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.88717155
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.82287698
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.80906022
28Parkinsons disease_Homo sapiens_hsa050121.78276914
29Oxidative phosphorylation_Homo sapiens_hsa001901.76671285
30Nucleotide excision repair_Homo sapiens_hsa034201.75292964
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.62984029
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.62197270
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.50959715
34Tryptophan metabolism_Homo sapiens_hsa003801.44752697
35Pentose phosphate pathway_Homo sapiens_hsa000301.38276598
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.38114239
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.35284632
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.30477832
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.29845204
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27934564
41Olfactory transduction_Homo sapiens_hsa047401.25740305
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25405923
43Chemical carcinogenesis_Homo sapiens_hsa052041.23599926
44Morphine addiction_Homo sapiens_hsa050321.23324831
45Cardiac muscle contraction_Homo sapiens_hsa042601.21670124
46Taste transduction_Homo sapiens_hsa047421.15850486
47Purine metabolism_Homo sapiens_hsa002301.14347530
48Systemic lupus erythematosus_Homo sapiens_hsa053221.12980211
49Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.12943351
50Hematopoietic cell lineage_Homo sapiens_hsa046401.12879384
51Retinol metabolism_Homo sapiens_hsa008301.12251903
52Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.09875266
53Basal transcription factors_Homo sapiens_hsa030221.09699795
54Alzheimers disease_Homo sapiens_hsa050101.09092471
55beta-Alanine metabolism_Homo sapiens_hsa004101.07164154
56Collecting duct acid secretion_Homo sapiens_hsa049661.05817120
57Huntingtons disease_Homo sapiens_hsa050161.05735892
58Maturity onset diabetes of the young_Homo sapiens_hsa049501.05691947
59Caffeine metabolism_Homo sapiens_hsa002321.05555026
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04506169
61RNA degradation_Homo sapiens_hsa030181.03752345
62Fanconi anemia pathway_Homo sapiens_hsa034601.02628072
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02140299
64Insulin secretion_Homo sapiens_hsa049110.99091590
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98166656
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96634646
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95797991
68Circadian entrainment_Homo sapiens_hsa047130.94928313
69Hedgehog signaling pathway_Homo sapiens_hsa043400.94886125
70B cell receptor signaling pathway_Homo sapiens_hsa046620.94544860
71Ether lipid metabolism_Homo sapiens_hsa005650.92689183
72GABAergic synapse_Homo sapiens_hsa047270.90723894
73Herpes simplex infection_Homo sapiens_hsa051680.87926682
74Glutamatergic synapse_Homo sapiens_hsa047240.87636750
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85149004
76Serotonergic synapse_Homo sapiens_hsa047260.83176994
77Sulfur metabolism_Homo sapiens_hsa009200.82947880
78Steroid biosynthesis_Homo sapiens_hsa001000.81319461
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80888218
80Other glycan degradation_Homo sapiens_hsa005110.80737313
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80203259
82Glycerolipid metabolism_Homo sapiens_hsa005610.78980537
83Basal cell carcinoma_Homo sapiens_hsa052170.78894212
84Antigen processing and presentation_Homo sapiens_hsa046120.78343789
85Thyroid cancer_Homo sapiens_hsa052160.77449419
86Alcoholism_Homo sapiens_hsa050340.76062001
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75701741
88Fat digestion and absorption_Homo sapiens_hsa049750.75355530
89Selenocompound metabolism_Homo sapiens_hsa004500.75189468
90Cell cycle_Homo sapiens_hsa041100.74620684
91Sphingolipid metabolism_Homo sapiens_hsa006000.74273542
92Peroxisome_Homo sapiens_hsa041460.74052890
93Dorso-ventral axis formation_Homo sapiens_hsa043200.73088825
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69275254
95Metabolic pathways_Homo sapiens_hsa011000.67516943
96p53 signaling pathway_Homo sapiens_hsa041150.66975969
97Shigellosis_Homo sapiens_hsa051310.66669751
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64732424
99Salivary secretion_Homo sapiens_hsa049700.63563083
100Dopaminergic synapse_Homo sapiens_hsa047280.62853050
101Acute myeloid leukemia_Homo sapiens_hsa052210.61860077
102Fatty acid degradation_Homo sapiens_hsa000710.61676037
103Ovarian steroidogenesis_Homo sapiens_hsa049130.60842507
104Measles_Homo sapiens_hsa051620.60030337
105ABC transporters_Homo sapiens_hsa020100.59696645
106Calcium signaling pathway_Homo sapiens_hsa040200.56205591
107Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55470048
108Cocaine addiction_Homo sapiens_hsa050300.54923671
109Histidine metabolism_Homo sapiens_hsa003400.53640281
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52973464
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52225632
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.50401839
113cAMP signaling pathway_Homo sapiens_hsa040240.48363588
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.46794545
115Regulation of autophagy_Homo sapiens_hsa041400.46763604
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46484882
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45544958
118Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44573725
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44554359
120Circadian rhythm_Homo sapiens_hsa047100.44372908
121Platelet activation_Homo sapiens_hsa046110.41992504
122RNA transport_Homo sapiens_hsa030130.41540030
123Epstein-Barr virus infection_Homo sapiens_hsa051690.41198919
124Amphetamine addiction_Homo sapiens_hsa050310.40802475
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40322890
126Tyrosine metabolism_Homo sapiens_hsa003500.39384081
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38436408
128Intestinal immune network for IgA production_Homo sapiens_hsa046720.36121822
129Fatty acid metabolism_Homo sapiens_hsa012120.35829509
130Malaria_Homo sapiens_hsa051440.35546710
131Leishmaniasis_Homo sapiens_hsa051400.35355643
132Glutathione metabolism_Homo sapiens_hsa004800.34048839
133Jak-STAT signaling pathway_Homo sapiens_hsa046300.33283696
134Arginine and proline metabolism_Homo sapiens_hsa003300.32978374
135NF-kappa B signaling pathway_Homo sapiens_hsa040640.32511030
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.32315408
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31765622
138Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30794133
139Long-term depression_Homo sapiens_hsa047300.30647230
140One carbon pool by folate_Homo sapiens_hsa006700.30076834
141Hepatitis B_Homo sapiens_hsa051610.29069123
142Viral carcinogenesis_Homo sapiens_hsa052030.28709790
143Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28629968
144Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.24726652
145NOD-like receptor signaling pathway_Homo sapiens_hsa046210.24674069
146Renin-angiotensin system_Homo sapiens_hsa046140.24518457
147Linoleic acid metabolism_Homo sapiens_hsa005910.24196918
148Pertussis_Homo sapiens_hsa051330.23660879
149Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.18256833
150Propanoate metabolism_Homo sapiens_hsa006400.16478960
151Arachidonic acid metabolism_Homo sapiens_hsa005900.14273660
152Legionellosis_Homo sapiens_hsa051340.13690542
153Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.13106862
154Allograft rejection_Homo sapiens_hsa053300.12285139

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