SFTA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to nitric oxide (GO:0071732)9.03435749
2negative regulation of complement activation (GO:0045916)7.34018050
3cellular response to reactive nitrogen species (GO:1902170)6.87481205
4negative regulation of protein activation cascade (GO:2000258)6.62402507
5response to nitric oxide (GO:0071731)6.50290286
6negative regulation of humoral immune response (GO:0002921)6.27087167
7macrophage chemotaxis (GO:0048246)6.23376899
8negative regulation of interleukin-2 production (GO:0032703)6.13395311
9respiratory gaseous exchange (GO:0007585)5.95923379
10one-carbon compound transport (GO:0019755)5.77393053
11surfactant homeostasis (GO:0043129)5.73711318
12axon ensheathment in central nervous system (GO:0032291)5.29569731
13central nervous system myelination (GO:0022010)5.29569731
14chemical homeostasis within a tissue (GO:0048875)5.12802851
15limb bud formation (GO:0060174)4.90503380
16peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.35910095
17peptide catabolic process (GO:0043171)4.19397648
18neuron cell-cell adhesion (GO:0007158)4.03281352
19trivalent inorganic anion homeostasis (GO:0072506)3.92743030
20phosphate ion homeostasis (GO:0055062)3.92743030
21membrane protein proteolysis (GO:0033619)3.85161725
22response to increased oxygen levels (GO:0036296)3.83506263
23response to hyperoxia (GO:0055093)3.83506263
24fatty acid elongation (GO:0030497)3.81905577
25complement activation, classical pathway (GO:0006958)3.81354391
26protein autoprocessing (GO:0016540)3.73441317
27response to vitamin A (GO:0033189)3.73206307
28pattern specification involved in kidney development (GO:0061004)3.71991547
29regulation of complement activation (GO:0030449)3.71564170
30presynaptic membrane assembly (GO:0097105)3.62956017
31activated T cell proliferation (GO:0050798)3.62874123
32iron ion import (GO:0097286)3.61088206
33response to interleukin-6 (GO:0070741)3.60410119
34long-chain fatty acid biosynthetic process (GO:0042759)3.57192882
35amino acid import (GO:0043090)3.52945553
36phosphate ion transmembrane transport (GO:0035435)3.51816747
37negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.51349785
38cerebral cortex radially oriented cell migration (GO:0021799)3.50053007
39dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.48279977
40renal absorption (GO:0070293)3.47727058
41regulation of protein activation cascade (GO:2000257)3.44405938
42photoreceptor cell differentiation (GO:0046530)3.43748874
43eye photoreceptor cell differentiation (GO:0001754)3.43748874
44cellular response to epinephrine stimulus (GO:0071872)3.42279169
45complement activation (GO:0006956)3.39491044
46myelination (GO:0042552)3.39480005
47positive regulation of digestive system process (GO:0060456)3.39076324
48response to epinephrine (GO:0071871)3.37414125
49retina layer formation (GO:0010842)3.32732314
50postsynaptic membrane organization (GO:0001941)3.32684607
51axon ensheathment (GO:0008366)3.31953601
52ensheathment of neurons (GO:0007272)3.31953601
53regulation of interleukin-2 biosynthetic process (GO:0045076)3.26794516
54neuron remodeling (GO:0016322)3.21788011
55presynaptic membrane organization (GO:0097090)3.21102836
56regulation of hippo signaling (GO:0035330)3.20410247
57neuron recognition (GO:0008038)3.17975091
58forebrain neuron differentiation (GO:0021879)3.16441828
59oligodendrocyte differentiation (GO:0048709)3.11208099
60cellular anion homeostasis (GO:0030002)3.05793845
61positive regulation of protein kinase C signaling (GO:0090037)3.05592348
62righting reflex (GO:0060013)3.04332123
63L-amino acid import (GO:0043092)3.04127490
64positive regulation of chemokine secretion (GO:0090197)3.03501297
65positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.02662671
66negative regulation of cytokine biosynthetic process (GO:0042036)2.97708128
67regulation of chemokine secretion (GO:0090196)2.96440219
68regulation of integrin-mediated signaling pathway (GO:2001044)2.94777845
69folic acid transport (GO:0015884)2.94606747
70regulation of phospholipid biosynthetic process (GO:0071071)2.93733420
71mesenchymal cell differentiation involved in renal system development (GO:2001012)2.91573330
72mesenchymal cell differentiation involved in kidney development (GO:0072161)2.91573330
73negative regulation of immunoglobulin mediated immune response (GO:0002890)2.88902519
74negative regulation of B cell mediated immunity (GO:0002713)2.88902519
75positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.88771115
76lateral sprouting from an epithelium (GO:0060601)2.86574698
77positive regulation of meiosis (GO:0045836)2.85653657
78branch elongation of an epithelium (GO:0060602)2.84349435
79transmission of nerve impulse (GO:0019226)2.81081370
80short-term memory (GO:0007614)2.80574957
81keratinocyte development (GO:0003334)2.79173487
82negative regulation of protein localization to cell surface (GO:2000009)2.78109234
83phosphate ion transport (GO:0006817)2.77835957
84membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.77659761
85sodium ion homeostasis (GO:0055078)2.77528224
86cellular response to thyroid hormone stimulus (GO:0097067)2.77191791
87protein activation cascade (GO:0072376)2.75592500
88multicellular organismal water homeostasis (GO:0050891)2.74641168
89positive regulation of phagocytosis (GO:0050766)2.73044511
90peptide cross-linking (GO:0018149)2.72750055
91organ growth (GO:0035265)2.72151908
92renal filtration (GO:0097205)2.72150405
93membrane raft organization (GO:0031579)2.72141785
94regulation of metalloenzyme activity (GO:0048552)2.72057459
95negative regulation of transcription by competitive promoter binding (GO:0010944)2.71655552
96ionotropic glutamate receptor signaling pathway (GO:0035235)2.71424567
97membrane repolarization during action potential (GO:0086011)2.69589362
98positive regulation of meiotic cell cycle (GO:0051446)2.69496029
99developmental induction (GO:0031128)2.68756299
100cell-cell signaling involved in cell fate commitment (GO:0045168)2.68325164
101regulation of collateral sprouting (GO:0048670)2.67257242
102retinal metabolic process (GO:0042574)2.66818601
103cerebral cortex cell migration (GO:0021795)2.65951669
104phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.65944561
105positive regulation of action potential (GO:0045760)2.64588754
106locomotory exploration behavior (GO:0035641)2.64141621
107negative regulation of neurotransmitter transport (GO:0051589)2.64079363
108Leydig cell differentiation (GO:0033327)2.61911363
109negative regulation of axon extension (GO:0030517)2.61587063
110response to redox state (GO:0051775)2.59976962
111glomerular filtration (GO:0003094)2.58769526
112positive regulation of synapse assembly (GO:0051965)2.57916017
113negative regulation of execution phase of apoptosis (GO:1900118)2.56523372
114axonal fasciculation (GO:0007413)2.55399004
115excretion (GO:0007588)2.53171334
116lung alveolus development (GO:0048286)2.52950809
117negative regulation of neurotransmitter secretion (GO:0046929)2.51307090
118calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.51059225
119otic vesicle formation (GO:0030916)2.50355857
120barbed-end actin filament capping (GO:0051016)2.50112709
121cranial nerve morphogenesis (GO:0021602)2.49158877
122water homeostasis (GO:0030104)2.48756956
123T cell mediated immunity (GO:0002456)2.48754481
124glutamate receptor signaling pathway (GO:0007215)2.48542328
125regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.47438227
126sympathetic nervous system development (GO:0048485)2.46938701
127vocalization behavior (GO:0071625)2.46215610
128negative regulation of axon guidance (GO:1902668)2.46179705
129sphingoid metabolic process (GO:0046519)2.44155027
130import into cell (GO:0098657)2.44112171
131startle response (GO:0001964)2.43213838
132GTP biosynthetic process (GO:0006183)2.42575702
133endothelial cell chemotaxis (GO:0035767)2.42404983
134transepithelial transport (GO:0070633)2.42261602
135gamma-aminobutyric acid signaling pathway (GO:0007214)2.41159102
136polyol transport (GO:0015791)2.40158240
137myelination in peripheral nervous system (GO:0022011)2.39506701
138peripheral nervous system axon ensheathment (GO:0032292)2.39506701
139transcytosis (GO:0045056)2.39336657
140daunorubicin metabolic process (GO:0044597)2.38852639
141polyketide metabolic process (GO:0030638)2.38852639
142doxorubicin metabolic process (GO:0044598)2.38852639
143negative regulation of protein autophosphorylation (GO:0031953)2.36869537
144regulation of timing of cell differentiation (GO:0048505)2.36182268
145tight junction assembly (GO:0070830)2.35493683
146norepinephrine metabolic process (GO:0042415)2.35492678
147response to catecholamine (GO:0071869)2.35492625
148response to monoamine (GO:0071867)2.35492625
149adhesion of symbiont to host cell (GO:0044650)2.34446117
150virion attachment to host cell (GO:0019062)2.34446117
151glucosamine-containing compound catabolic process (GO:1901072)2.34298637
152telencephalon cell migration (GO:0022029)2.33739987
153regulation of inositol phosphate biosynthetic process (GO:0010919)2.32534530
154cranial nerve development (GO:0021545)2.31817948
155endocrine hormone secretion (GO:0060986)2.31648211
156neuronal action potential propagation (GO:0019227)2.31462984
157positive regulation of neurological system process (GO:0031646)2.31426736
158cerebral cortex neuron differentiation (GO:0021895)2.31061230
159regulation of transmission of nerve impulse (GO:0051969)2.30594899
160regulation of humoral immune response (GO:0002920)2.29663310
161positive regulation of oligodendrocyte differentiation (GO:0048714)2.29649742
162regulation of neuron projection regeneration (GO:0070570)2.29560127
163regulation of axon regeneration (GO:0048679)2.29560127
164positive regulation of actin filament depolymerization (GO:0030836)2.29006460
165positive regulation of endothelial cell differentiation (GO:0045603)2.28915988
166regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.28613554
167regulation of platelet aggregation (GO:0090330)2.28564674
168negative regulation of axon extension involved in axon guidance (GO:0048843)2.28145684
169negative regulation of T cell proliferation (GO:0042130)2.27953620
170toxin transport (GO:1901998)2.27474395
171sphingosine metabolic process (GO:0006670)2.27281334
172response to thyroid hormone (GO:0097066)2.27266840
173camera-type eye morphogenesis (GO:0048593)2.26597992
174cellular response to catecholamine stimulus (GO:0071870)2.25802411
175cellular response to monoamine stimulus (GO:0071868)2.25802411
176lung secretory cell differentiation (GO:0061140)2.25307684
177ectoderm development (GO:0007398)2.24517585
178reflex (GO:0060004)2.24300163
179regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.22327562
180superoxide anion generation (GO:0042554)2.21898926
181negative regulation of synaptic transmission, GABAergic (GO:0032229)2.21308789
182lymphoid progenitor cell differentiation (GO:0002320)2.21202350
183dendritic spine morphogenesis (GO:0060997)2.21195508
184regulation of pigment cell differentiation (GO:0050932)2.21141404
185cellular response to hepatocyte growth factor stimulus (GO:0035729)2.18589834
186response to hepatocyte growth factor (GO:0035728)2.18589834
187regulation of phagocytosis (GO:0050764)2.16167307
188prostanoid metabolic process (GO:0006692)2.15543951
189prostaglandin metabolic process (GO:0006693)2.15543951
190neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.12826728
191aminoglycoside antibiotic metabolic process (GO:0030647)2.10369083
192nephron tubule formation (GO:0072079)2.09622848
193regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.08838452
194lipoxygenase pathway (GO:0019372)2.06018099

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.50383908
2ESR1_21235772_ChIP-Seq_MCF-7_Human4.22980069
3EZH2_22144423_ChIP-Seq_EOC_Human3.56719136
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.37623733
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.02246106
6GBX2_23144817_ChIP-Seq_PC3_Human2.96770426
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.89974276
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.83173271
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.80044958
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.78198558
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.74606250
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.53736602
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.45823709
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.45159647
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.44270340
16TAF15_26573619_Chip-Seq_HEK293_Human2.44007499
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.43344898
18AR_21572438_ChIP-Seq_LNCaP_Human2.43119184
19SOX2_20726797_ChIP-Seq_SW620_Human2.35432627
20CBX2_27304074_Chip-Seq_ESCs_Mouse2.35354592
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.30666852
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.26652666
23RNF2_18974828_ChIP-Seq_MESCs_Mouse2.26462260
24EZH2_18974828_ChIP-Seq_MESCs_Mouse2.26462260
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.25977936
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.24825490
27ZFP57_27257070_Chip-Seq_ESCs_Mouse2.20530212
28JARID2_20075857_ChIP-Seq_MESCs_Mouse2.13463057
29BMI1_23680149_ChIP-Seq_NPCS_Mouse2.08568032
30BP1_19119308_ChIP-ChIP_Hs578T_Human2.01175542
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.99831697
32GATA4_25053715_ChIP-Seq_YYC3_Human1.97295104
33CLOCK_20551151_ChIP-Seq_293T_Human1.96581506
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.95956043
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.94343828
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.93124447
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.90360305
38VDR_22108803_ChIP-Seq_LS180_Human1.90086676
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.87622737
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.87353097
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.86781164
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.86259140
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.84996987
44ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.84387449
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.81970754
46SOX2_27498859_Chip-Seq_STOMACH_Mouse1.81190963
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.79900881
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79478906
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78281685
50SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.77415345
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.75509680
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.74258115
53RACK7_27058665_Chip-Seq_MCF-7_Human1.73122710
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.73083402
55RNF2_27304074_Chip-Seq_NSC_Mouse1.73046941
56P300_19829295_ChIP-Seq_ESCs_Human1.72448391
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.72035136
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68284568
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67619703
60KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.67534709
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67216799
62IRF8_22096565_ChIP-ChIP_GC-B_Human1.67020823
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66272377
64LXR_22158963_ChIP-Seq_LIVER_Mouse1.65972654
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.65570481
66SALL4_18804426_ChIP-ChIP_XEN_Mouse1.63302440
67KLF5_25053715_ChIP-Seq_YYC3_Human1.62737241
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62321917
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.60012252
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58560872
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.54637270
72IGF1R_20145208_ChIP-Seq_DFB_Human1.52278335
73RUNX1_27514584_Chip-Seq_MCF-7_Human1.51388562
74ER_23166858_ChIP-Seq_MCF-7_Human1.49277452
75RXR_22158963_ChIP-Seq_LIVER_Mouse1.47915669
76ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46916163
77FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.46202375
78SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.45724119
79SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.45724119
80TP53_18474530_ChIP-ChIP_U2OS_Human1.45686411
81FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.44248080
82FUS_26573619_Chip-Seq_HEK293_Human1.44070164
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43915259
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43006359
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.42805868
86CJUN_26792858_Chip-Seq_BT549_Human1.42690043
87AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.41135020
88GATA6_25053715_ChIP-Seq_YYC3_Human1.40208840
89ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.38437692
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37012921
91EP300_21415370_ChIP-Seq_HL-1_Mouse1.36547841
92PPARA_22158963_ChIP-Seq_LIVER_Mouse1.36400004
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36064330
94WT1_19549856_ChIP-ChIP_CCG9911_Human1.35702256
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35037100
96SMAD4_21799915_ChIP-Seq_A2780_Human1.34452530
97NFIB_24661679_ChIP-Seq_LUNG_Mouse1.34301145
98ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34290383
99CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.34164298
100TCF4_18268006_ChIP-ChIP_LS174T_Human1.33294160
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33288415
102EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32000224
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.31495659
104TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28748426
105SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28303901
106FLI1_27457419_Chip-Seq_LIVER_Mouse1.25966195
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25628085
108PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23807264
109GATA3_24758297_ChIP-Seq_MCF-7_Human1.23383481
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22953491
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22953491
112TP53_16413492_ChIP-PET_HCT116_Human1.22845667
113AHR_22903824_ChIP-Seq_MCF-7_Human1.22560929
114TP63_17297297_ChIP-ChIP_HaCaT_Human1.22439322
115NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.22420781
116EZH2_27294783_Chip-Seq_NPCs_Mouse1.21886956
117CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20649407
118P63_26484246_Chip-Seq_KERATINOCYTES_Human1.19838476
119ARNT_22903824_ChIP-Seq_MCF-7_Human1.19593939
120CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18970410
121TBX20_22328084_ChIP-Seq_HEART_Mouse1.18414390
122TBX20_22080862_ChIP-Seq_HEART_Mouse1.18414390
123E2F1_18555785_Chip-Seq_ESCs_Mouse1.18267827
124CMYC_18555785_Chip-Seq_ESCs_Mouse1.17082737
125P53_22387025_ChIP-Seq_ESCs_Mouse1.16935356
126RUNX2_22187159_ChIP-Seq_PCA_Human1.16650914
127NFE2_27457419_Chip-Seq_LIVER_Mouse1.16131254
128SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15297220
129POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15294147
130ELK3_25401928_ChIP-Seq_HUVEC_Human1.14587532
131STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12533686
132P300_18555785_Chip-Seq_ESCs_Mouse1.12143194
133FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11887766
134AR_25329375_ChIP-Seq_VCAP_Human1.11013434
135EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10020822
136SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09625981
137AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09192582
138TRIM28_21343339_ChIP-Seq_HEK293_Human1.09126380
139BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09055031
140ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09040926
141LXR_22292898_ChIP-Seq_THP-1_Human1.08541269
142PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.07192116
143CREB1_26743006_Chip-Seq_LNCaP_Human1.05978080
144KDM2B_26808549_Chip-Seq_REH_Human1.05635800
145SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05384303
146STAT3_18555785_Chip-Seq_ESCs_Mouse1.04510139
147DROSHA_22980978_ChIP-Seq_HELA_Human1.04111708
148LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04073139
149* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03548004
150IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03367104
151RING1B_27294783_Chip-Seq_ESCs_Mouse1.03047141
152CDX2_20551321_ChIP-Seq_CACO-2_Human1.02683955
153TAL1_26923725_Chip-Seq_HPCs_Mouse1.02557504
154RING1B_27294783_Chip-Seq_NPCs_Mouse1.02158378
155TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01628290
156NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01233542
157CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01025425
158FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99809389
159RUNX1_27457419_Chip-Seq_LIVER_Mouse0.99707230
160NMYC_18555785_Chip-Seq_ESCs_Mouse0.99641843
161PRDM14_20953172_ChIP-Seq_ESCs_Human0.99565466
162REST_21632747_ChIP-Seq_MESCs_Mouse0.98825918
163FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98580776
164RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95382203
165FOXA2_19822575_ChIP-Seq_HepG2_Human0.93322809
166Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89617762
167IRF8_21731497_ChIP-ChIP_J774_Mouse0.86269052
168KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85548951
169TP63_23658742_ChIP-Seq_EP156T_Human0.85205216
170PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84918309
171JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83721199
172ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82885078
173PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81845869
174SMAD3_21741376_ChIP-Seq_HESCs_Human0.81188978
175JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78321212
176SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.78287155
177GATA1_19941826_ChIP-Seq_K562_Human0.77609812
178GATA1_22025678_ChIP-Seq_K562_Human0.76762271
179STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.76657896
180FOXA1_25552417_ChIP-Seq_VCAP_Human0.76301270
181ATF3_27146783_Chip-Seq_COLON_Human0.74044929
182ELF5_23300383_ChIP-Seq_T47D_Human0.73998440
183ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.72382356
184IRF8_27001747_Chip-Seq_BMDM_Mouse0.69516087

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004782_abnormal_surfactant_physiolog4.12557458
2MP0003880_abnormal_central_pattern4.02403020
3MP0003136_yellow_coat_color3.83210989
4MP0002102_abnormal_ear_morphology3.23122615
5MP0008995_early_reproductive_senescence3.08918732
6MP0004742_abnormal_vestibular_system2.99852865
7MP0010234_abnormal_vibrissa_follicle2.75879999
8MP0000566_synostosis2.63195894
9MP0005409_darkened_coat_color2.56488568
10MP0000920_abnormal_myelination2.37045135
11MP0001188_hyperpigmentation2.17528163
12MP0001486_abnormal_startle_reflex2.05828225
13MP0001440_abnormal_grooming_behavior2.04248657
14MP0002138_abnormal_hepatobiliary_system2.00561532
15MP0005423_abnormal_somatic_nervous1.98611851
16MP0002277_abnormal_respiratory_mucosa1.97886129
17MP0000462_abnormal_digestive_system1.92015380
18MP0006292_abnormal_olfactory_placode1.86839074
19MP0003724_increased_susceptibility_to1.85495334
20MP0001177_atelectasis1.81964794
21MP0001958_emphysema1.81085422
22MP0009379_abnormal_foot_pigmentation1.80953995
23MP0008004_abnormal_stomach_pH1.79267466
24MP0005058_abnormal_lysosome_morphology1.77633721
25MP0005645_abnormal_hypothalamus_physiol1.74290606
26MP0009745_abnormal_behavioral_response1.74101047
27MP0005171_absent_coat_pigmentation1.69862472
28MP0000778_abnormal_nervous_system1.69619858
29MP0004381_abnormal_hair_follicle1.65639479
30MP0003191_abnormal_cellular_cholesterol1.64937428
31MP0003950_abnormal_plasma_membrane1.63635854
32MP0002132_abnormal_respiratory_system1.61296567
33MP0002272_abnormal_nervous_system1.60166455
34MP0003938_abnormal_ear_development1.56742573
35MP0001905_abnormal_dopamine_level1.54567887
36MP0010352_gastrointestinal_tract_polyps1.54379440
37MP0002295_abnormal_pulmonary_circulatio1.53786802
38MP0000631_abnormal_neuroendocrine_gland1.53583219
39MP0003635_abnormal_synaptic_transmissio1.52597724
40MP0001542_abnormal_bone_strength1.51933983
41MP0002064_seizures1.51835435
42MP0002133_abnormal_respiratory_system1.51020138
43MP0005388_respiratory_system_phenotype1.51020138
44MP0004270_analgesia1.47189128
45MP0001968_abnormal_touch/_nociception1.47072693
46MP0003786_premature_aging1.45793445
47MP0000026_abnormal_inner_ear1.44718152
48MP0001485_abnormal_pinna_reflex1.44548688
49MP0002572_abnormal_emotion/affect_behav1.43000944
50MP0004142_abnormal_muscle_tone1.42051839
51MP0003566_abnormal_cell_adhesion1.37289694
52MP0010368_abnormal_lymphatic_system1.36359971
53MP0006276_abnormal_autonomic_nervous1.35061834
54MP0009046_muscle_twitch1.34442568
55MP0003300_gastrointestinal_ulcer1.33401238
56MP0004134_abnormal_chest_morphology1.32953976
57MP0003690_abnormal_glial_cell1.32233630
58MP0005023_abnormal_wound_healing1.32192306
59MP0009780_abnormal_chondrocyte_physiolo1.31639841
60MP0002249_abnormal_larynx_morphology1.31344079
61MP0005275_abnormal_skin_tensile1.31009017
62MP0001963_abnormal_hearing_physiology1.29810538
63MP0004145_abnormal_muscle_electrophysio1.29574256
64MP0002557_abnormal_social/conspecific_i1.28142193
65MP0002067_abnormal_sensory_capabilities1.26567693
66MP0003937_abnormal_limbs/digits/tail_de1.24132799
67MP0004019_abnormal_vitamin_homeostasis1.23260334
68MP0002735_abnormal_chemical_nociception1.23121771
69MP0002405_respiratory_system_inflammati1.21983229
70MP0001501_abnormal_sleep_pattern1.20561026
71MP0002063_abnormal_learning/memory/cond1.20111705
72MP0001529_abnormal_vocalization1.19890106
73MP0002734_abnormal_mechanical_nocicepti1.17697499
74MP0005166_decreased_susceptibility_to1.16492003
75MP0001346_abnormal_lacrimal_gland1.15128171
76MP0002184_abnormal_innervation1.13183250
77MP0005085_abnormal_gallbladder_physiolo1.13000832
78MP0008875_abnormal_xenobiotic_pharmacok1.12715933
79MP0009250_abnormal_appendicular_skeleto1.11111070
80MP0002254_reproductive_system_inflammat1.10189941
81MP0005551_abnormal_eye_electrophysiolog1.10176083
82MP0001756_abnormal_urination1.09011169
83MP0003453_abnormal_keratinocyte_physiol1.08621717
84MP0000383_abnormal_hair_follicle1.08055036
85MP0005646_abnormal_pituitary_gland1.07757086
86MP0002752_abnormal_somatic_nervous1.07655351
87MP0000762_abnormal_tongue_morphology1.07096716
88MP0005257_abnormal_intraocular_pressure1.05865470
89MP0005165_increased_susceptibility_to1.05187036
90MP0003634_abnormal_glial_cell1.03633109
91MP0002282_abnormal_trachea_morphology1.02340185
92MP0002736_abnormal_nociception_after1.01598102
93MP0004885_abnormal_endolymph1.01402283
94MP0002733_abnormal_thermal_nociception1.00576787
95MP0004043_abnormal_pH_regulation1.00413556
96MP0004859_abnormal_synaptic_plasticity1.00334531
97MP0001790_abnormal_immune_system1.00286787
98MP0005387_immune_system_phenotype1.00286787
99MP0001970_abnormal_pain_threshold0.99281431
100MP0009840_abnormal_foam_cell0.99133492
101MP0000465_gastrointestinal_hemorrhage0.98884950
102MP0003385_abnormal_body_wall0.98278407
103MP0005083_abnormal_biliary_tract0.97327222
104MP0002796_impaired_skin_barrier0.96906401
105MP0001664_abnormal_digestion0.95896205
106MP0005379_endocrine/exocrine_gland_phen0.95282179
107MP0003303_peritoneal_inflammation0.94645795
108MP0005365_abnormal_bile_salt0.94581800
109MP0004264_abnormal_extraembryonic_tissu0.93325551
110MP0002098_abnormal_vibrissa_morphology0.92791954
111MP0002882_abnormal_neuron_morphology0.91536696
112MP0005025_abnormal_response_to0.91123862
113MP0008260_abnormal_autophagy0.89996386
114MP0009643_abnormal_urine_homeostasis0.89425200
115MP0001851_eye_inflammation0.88897882
116MP0002163_abnormal_gland_morphology0.88770266
117MP0001175_abnormal_lung_morphology0.88467258
118MP0005195_abnormal_posterior_eye0.87124320
119MP0010678_abnormal_skin_adnexa0.87114754
120MP0004947_skin_inflammation0.85683250
121MP0000685_abnormal_immune_system0.85594949
122MP0003091_abnormal_cell_migration0.85401994
123MP0003045_fibrosis0.85091778
124MP0005503_abnormal_tendon_morphology0.84400661
125MP0001943_abnormal_respiration0.84365324
126MP0001502_abnormal_circadian_rhythm0.81858131
127MP0002998_abnormal_bone_remodeling0.81699929
128MP0001661_extended_life_span0.81512218
129MP0005595_abnormal_vascular_smooth0.81164690
130MP0000049_abnormal_middle_ear0.80196198
131MP0005410_abnormal_fertilization0.79879006
132MP0002148_abnormal_hypersensitivity_rea0.79822326
133MP0004484_altered_response_of0.79261790
134MP0002136_abnormal_kidney_physiology0.78792316
135MP0005164_abnormal_response_to0.78488963
136MP0003075_altered_response_to0.78172797
137MP0002751_abnormal_autonomic_nervous0.78139918
138MP0001340_abnormal_eyelid_morphology0.77818183
139MP0002066_abnormal_motor_capabilities/c0.77697865
140MP0002118_abnormal_lipid_homeostasis0.77566930
141MP0004510_myositis0.76773321
142MP0010386_abnormal_urinary_bladder0.74933115
143MP0005167_abnormal_blood-brain_barrier0.74765071
144MP0004272_abnormal_basement_membrane0.72899342
145MP0000681_abnormal_thyroid_gland0.72857924
146MP0003638_abnormal_response/metabolism_0.72666768
147MP0004883_abnormal_blood_vessel0.72304969
148MP0000955_abnormal_spinal_cord0.71952077
149MP0002229_neurodegeneration0.71841424
150MP0004133_heterotaxia0.71202779
151MP0005408_hypopigmentation0.70002922
152MP0000249_abnormal_blood_vessel0.69276441
153MP0000343_altered_response_to0.69159593
154MP0002233_abnormal_nose_morphology0.69106374
155MP0009785_altered_susceptibility_to0.66416476
156MP0008469_abnormal_protein_level0.66062287
157MP0001881_abnormal_mammary_gland0.65409806
158MP0002419_abnormal_innate_immunity0.64242475
159MP0001879_abnormal_lymphatic_vessel0.60843050
160MP0006138_congestive_heart_failure0.59748453
161MP0005332_abnormal_amino_acid0.58596356
162MP0000627_abnormal_mammary_gland0.57109230
163MP0001873_stomach_inflammation0.56340143
164MP0000470_abnormal_stomach_morphology0.53771696
165MP0003448_altered_tumor_morphology0.51374203
166MP0004084_abnormal_cardiac_muscle0.49761222
167MP0001216_abnormal_epidermal_layer0.49068193
168MP0003436_decreased_susceptibility_to0.47690862
169MP0001533_abnormal_skeleton_physiology0.47489968
170MP0010155_abnormal_intestine_physiology0.47154268
171MP0005076_abnormal_cell_differentiation0.46866149
172MP0003828_pulmonary_edema0.44500494
173MP0003115_abnormal_respiratory_system0.44290783
174MP0002168_other_aberrant_phenotype0.43469285

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)4.39181499
2Systemic lupus erythematosus (HP:0002725)4.21438599
3Dynein arm defect of respiratory motile cilia (HP:0012255)3.94233765
4Absent/shortened dynein arms (HP:0200106)3.94233765
5Abnormal ciliary motility (HP:0012262)3.92180934
6Gout (HP:0001997)3.86391389
7Interstitial pulmonary disease (HP:0006530)3.83603340
8Decreased circulating renin level (HP:0003351)3.82352099
9Septo-optic dysplasia (HP:0100842)3.76982506
10Abnormality of the fingertips (HP:0001211)3.76633688
11Parakeratosis (HP:0001036)3.63750500
12Complement deficiency (HP:0004431)3.62908369
13Glomerulonephritis (HP:0000099)3.59041775
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.53737582
15Tubulointerstitial nephritis (HP:0001970)3.47039661
16Abnormal respiratory motile cilium physiology (HP:0012261)3.40892401
17Vascular calcification (HP:0004934)3.35764892
18Absent septum pellucidum (HP:0001331)3.25392330
19Abnormal respiratory motile cilium morphology (HP:0005938)3.17453864
20Abnormal respiratory epithelium morphology (HP:0012253)3.17453864
21Eczematoid dermatitis (HP:0000976)3.07623116
22Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.02333762
23Degeneration of the lateral corticospinal tracts (HP:0002314)3.02333762
24Abnormality of complement system (HP:0005339)3.01755395
25Cardiovascular calcification (HP:0011915)3.00681888
26Tubulointerstitial fibrosis (HP:0005576)3.00569421
27Abnormality of the septum pellucidum (HP:0007375)2.95921122
28Cerebral inclusion bodies (HP:0100314)2.91389786
29Increased purine levels (HP:0004368)2.91297142
30Hyperuricemia (HP:0002149)2.91297142
31Aplasia cutis congenita (HP:0001057)2.90540670
32Partial duplication of thumb phalanx (HP:0009944)2.89540724
33Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.86465126
34Nephritis (HP:0000123)2.86132131
35Nasolacrimal duct obstruction (HP:0000579)2.82704879
36Hoarse voice (HP:0001609)2.80812200
37Pulmonary hypertension (HP:0002092)2.80667003
38Synostosis involving the elbow (HP:0003938)2.73327615
39Humeroradial synostosis (HP:0003041)2.73327615
40Alacrima (HP:0000522)2.69507504
41Abnormality of renin-angiotensin system (HP:0000847)2.69076275
42Cupped ear (HP:0000378)2.68377368
43Hyperaldosteronism (HP:0000859)2.63978786
44Abnormality of the phalanges of the 2nd finger (HP:0009541)2.63094325
45Tubulointerstitial abnormality (HP:0001969)2.62976173
46Alveolar cell carcinoma (HP:0006519)2.60839694
47Osteolytic defects of the phalanges of the hand (HP:0009771)2.59224235
48Osteolytic defects of the hand bones (HP:0009699)2.59224235
49Glomerulosclerosis (HP:0000096)2.56717997
50Abnormality of the lacrimal duct (HP:0011481)2.56046163
51Duplication of thumb phalanx (HP:0009942)2.55930741
52Thoracic kyphosis (HP:0002942)2.51156721
53Prolonged neonatal jaundice (HP:0006579)2.49867838
54Exertional dyspnea (HP:0002875)2.48872851
55Ventricular fibrillation (HP:0001663)2.47170208
56Rectal prolapse (HP:0002035)2.44975817
57Abnormality of the pulmonary veins (HP:0011718)2.44240829
58Conical tooth (HP:0000698)2.44134043
59Aplasia involving bones of the upper limbs (HP:0009823)2.43640680
60Aplasia of the phalanges of the hand (HP:0009802)2.43640680
61Aplasia involving bones of the extremities (HP:0009825)2.43640680
62Thyroid-stimulating hormone excess (HP:0002925)2.42241938
63Pulmonary fibrosis (HP:0002206)2.41456237
64Partial duplication of the phalanx of hand (HP:0009999)2.40711567
65Loss of speech (HP:0002371)2.40569272
66White forelock (HP:0002211)2.40207738
67Abnormality of incisor morphology (HP:0011063)2.39909133
68Anophthalmia (HP:0000528)2.39690138
69Growth hormone excess (HP:0000845)2.39275160
70Abnormality of the dental pulp (HP:0006479)2.39249784
71Abnormality of the nasolacrimal system (HP:0000614)2.38269855
72Neoplasm of the tracheobronchial system (HP:0100552)2.36602238
73Abnormality of permanent molar morphology (HP:0011071)2.34374631
74Abnormality of the dental root (HP:0006486)2.34374631
75Taurodontia (HP:0000679)2.34374631
76Abnormality of the axillary hair (HP:0100134)2.32573243
77Abnormality of secondary sexual hair (HP:0009888)2.32573243
78Optic nerve hypoplasia (HP:0000609)2.31126914
79Focal motor seizures (HP:0011153)2.29888740
80Respiratory distress (HP:0002098)2.28761892
81Decreased lacrimation (HP:0000633)2.28083732
82Sensory axonal neuropathy (HP:0003390)2.28067352
83Supranuclear gaze palsy (HP:0000605)2.26116130
84Split foot (HP:0001839)2.24691937
85Congenital malformation of the right heart (HP:0011723)2.24188630
86Double outlet right ventricle (HP:0001719)2.24188630
87Hypomagnesemia (HP:0002917)2.23400628
88Hyperkalemia (HP:0002153)2.22938453
89Overfolded helix (HP:0000396)2.21442711
90Neonatal respiratory distress (HP:0002643)2.21018158
91Patchy hypopigmentation of hair (HP:0011365)2.20170820
92Anomalous pulmonary venous return (HP:0010772)2.20140562
93Abnormality of molar morphology (HP:0011070)2.17953954
94Abnormality of molar (HP:0011077)2.17953954
95Abnormality of renal excretion (HP:0011036)2.16451075
96Thickened helices (HP:0000391)2.12746185
97Peripheral hypomyelination (HP:0007182)2.12544292
98Distal lower limb muscle weakness (HP:0009053)2.12286412
99Hypotension (HP:0002615)2.11972091
100Congenital sensorineural hearing impairment (HP:0008527)2.11669622
101Renal salt wasting (HP:0000127)2.11641188
102Chronic bronchitis (HP:0004469)2.10269732
103Rhinitis (HP:0012384)2.10229915
104Chin dimple (HP:0010751)2.09474562
105Mixed hearing impairment (HP:0000410)2.07128940
106Renal Fanconi syndrome (HP:0001994)2.06934595
107Right ventricular cardiomyopathy (HP:0011663)2.05717374
108Absent speech (HP:0001344)2.04659534
109Hypophosphatemic rickets (HP:0004912)2.04065848
110Retinal dysplasia (HP:0007973)2.02788009
111Restrictive lung disease (HP:0002091)2.02464834
112Esophageal atresia (HP:0002032)2.00102975
113Hypokalemic alkalosis (HP:0001949)1.99030155
114Hyperpituitarism (HP:0010514)1.96490331
115Abnormality of the corticospinal tract (HP:0002492)1.96268316
116Polycythemia (HP:0001901)1.96121131
117Pulmonary artery stenosis (HP:0004415)1.94780290
118Seborrheic dermatitis (HP:0001051)1.94767803
119Adrenal hypoplasia (HP:0000835)1.93211238
120Aplasia/Hypoplasia of the tibia (HP:0005772)1.92167809
121Focal segmental glomerulosclerosis (HP:0000097)1.91853198
122Tachypnea (HP:0002789)1.90419735
123Hypergammaglobulinemia (HP:0010702)1.88874631
124Abnormality of the thoracic spine (HP:0100711)1.88667845
125Tubular atrophy (HP:0000092)1.87566685
126Partial agenesis of the corpus callosum (HP:0001338)1.85462062
127Abnormality of monocarboxylic acid metabolism (HP:0010996)1.85184021
128Short tibia (HP:0005736)1.84986696
129Abnormality of the parietal bone (HP:0002696)1.84566288
130Abnormality of purine metabolism (HP:0004352)1.84374667
131Abnormally folded helix (HP:0008544)1.83962259
132Duplicated collecting system (HP:0000081)1.83601625
133Hyperactive renin-angiotensin system (HP:0000841)1.83316310
134Xerostomia (HP:0000217)1.83090489
135Congenital ichthyosiform erythroderma (HP:0007431)1.80497386
136Neoplasm of the lung (HP:0100526)1.80426070
137Premature skin wrinkling (HP:0100678)1.80251240
138Thick nail (HP:0001805)1.79935708
139Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79263439
140Symphalangism affecting the phalanges of the hand (HP:0009773)1.79060370
141Hypoplasia of the iris (HP:0007676)1.78878393
142Abnormality of the parathyroid morphology (HP:0011766)1.77837384
143Midline defect of the nose (HP:0004122)1.77547320
144Abnormality of chloride homeostasis (HP:0011422)1.76217171
145Nonprogressive disorder (HP:0003680)1.74933192
146Broad-based gait (HP:0002136)1.74471903
147Stage 5 chronic kidney disease (HP:0003774)1.73576307
148Recurrent corneal erosions (HP:0000495)1.73220883
149Bone cyst (HP:0012062)1.72001713
150Aortic aneurysm (HP:0004942)1.71590433
151Genital tract atresia (HP:0001827)1.71570065
152Abnormality of the nasal mucosa (HP:0000433)1.71433029
153Germ cell neoplasia (HP:0100728)1.70827863
154Potter facies (HP:0002009)1.70035053
155Facial shape deformation (HP:0011334)1.70035053
156Vaginal atresia (HP:0000148)1.69426730
157Hyperventilation (HP:0002883)1.69291636
158Vascular tortuosity (HP:0004948)1.68670252
159Abnormality of macrophages (HP:0004311)1.67938257
160Goiter (HP:0000853)1.65958791
161Rapidly progressive (HP:0003678)1.65769671
162Hyponatremia (HP:0002902)1.64084409
163Recurrent gram-negative bacterial infections (HP:0005420)1.62240135
164Abnormality of glycosphingolipid metabolism (HP:0004343)1.61129404
165Abnormality of glycolipid metabolism (HP:0010969)1.61129404
166Abnormality of liposaccharide metabolism (HP:0010968)1.61129404
167Broad face (HP:0000283)1.60930317
168Deep venous thrombosis (HP:0002625)1.60372241
169Arterial tortuosity (HP:0005116)1.58278659
170Large for gestational age (HP:0001520)1.57017853
171Steatorrhea (HP:0002570)1.54958257
172Alopecia of scalp (HP:0002293)1.53291719
173Bronchitis (HP:0012387)1.52966382
174Segmental peripheral demyelination/remyelination (HP:0003481)1.52881881
175Abnormality of sodium homeostasis (HP:0010931)1.48387979
176Ulnar claw (HP:0001178)1.47058694
177Esophageal varix (HP:0002040)1.46342523
178Oligodontia (HP:0000677)1.45729881
179Joint swelling (HP:0001386)1.45538871
180Increased CSF protein (HP:0002922)1.44843401
181Mitral stenosis (HP:0001718)1.44729625
182Macular degeneration (HP:0000608)1.43878698

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.60460262
2LMTK25.48096701
3CASK5.32798200
4BLK3.79810436
5TNIK3.07599722
6STK392.99260616
7EPHA32.97716911
8LATS12.53291783
9PKN12.30207572
10MKNK22.28856840
11PINK12.27512901
12FES2.23987718
13ZAP702.23812314
14MAPKAPK32.22123969
15OXSR12.17953775
16PBK2.02547940
17LRRK21.90609524
18MAP3K31.74206501
19FGFR41.70496921
20GRK71.69751345
21RIPK11.64757386
22ABL21.64605588
23EPHA41.63438186
24FGR1.61154206
25TRIB31.58978457
26MAPK131.57729981
27EPHB11.53620607
28MST41.51812934
29TGFBR21.51410125
30MKNK11.49191469
31NEK61.47085375
32ERN11.45664996
33MYLK1.45334276
34ADRBK21.42873241
35BMPR1B1.42780476
36MAPK151.37327080
37BCR1.35000991
38WNK41.33280541
39PNCK1.32599211
40FGFR21.29277002
41NEK91.28935466
42NTRK31.26518845
43TYRO31.26496680
44MUSK1.23729917
45GRK11.23088550
46STK161.21057067
47YES11.20248253
48IRAK11.15646445
49FGFR31.15048269
50IRAK21.12755994
51NUAK11.10584184
52PAK41.10191033
53PDPK11.09066093
54RIPK41.08797575
55CDK191.07510626
56PRKG21.04619414
57IRAK41.02464754
58MAP3K61.01893949
59LIMK11.01780192
60PRPF4B1.01689269
61EPHB21.01541950
62CDC42BPA1.01471235
63BMPR20.98923201
64CLK10.98812805
65PRKCE0.98684927
66HIPK20.97255475
67MAP3K10.95381535
68PKN20.94711419
69RPS6KA20.94609509
70STK38L0.94142144
71CHUK0.93202511
72MAPKAPK50.90987303
73ROCK20.90451174
74TESK10.90336554
75NME10.89520116
76PRKCQ0.89440617
77DMPK0.89176320
78MARK10.89164894
79MAP3K140.89025154
80INSRR0.88995177
81DYRK20.87793537
82PRKD20.87437944
83CDK120.87313611
84MAP3K20.87151559
85CSK0.87106957
86TBK10.85631514
87STK240.83905613
88CAMK2B0.83473258
89MAP3K120.81343463
90PDGFRB0.81127434
91NTRK10.80790899
92UHMK10.80138811
93LATS20.79739503
94MAP2K60.79262257
95PTK60.78493565
96PRKD10.77759802
97CAMK2A0.76625595
98PHKG10.72590660
99PHKG20.72590660
100TIE10.71820518
101EIF2AK20.70520729
102DAPK20.68666816
103STK100.67300312
104WNK10.66608980
105TAOK30.66103578
106RPS6KA60.65505880
107SMG10.64687947
108MAP3K70.64264669
109PTK20.63445628
110MAP2K30.62526849
111CSNK1G30.60954021
112ERBB40.60819135
113TAOK10.58669922
114GRK50.57744856
115MAP3K130.57626394
116CDK30.57274846
117CAMK1G0.57187955
118CSNK1A1L0.57185853
119PRKG10.57023461
120DYRK1A0.55729672
121TYK20.55571224
122MAP3K90.54606314
123MET0.54370505
124MST1R0.54018375
125SIK20.53968594
126CSNK1G10.53644455
127GSK3A0.52934723
128TNK20.52859422
129MAP2K70.52833166
130FYN0.52714342
131ROCK10.52005546
132RPS6KL10.51136705
133RPS6KC10.51136705
134JAK10.50333788
135RET0.49967106
136SIK10.48900048
137SGK2230.48602518
138SGK4940.48602518
139PLK20.48428507
140RPS6KB20.47899423
141NTRK20.47687510
142EGFR0.47138390
143MAPKAPK20.46848414
144MAP2K20.45949611
145CAMK2D0.45915043
146CSNK1G20.45865127
147PAK30.45735508
148STK380.45579407
149FER0.44999558
150PRKAA20.44721309
151TLK10.43905892
152MARK20.42876900
153RPS6KA50.42649202
154NLK0.42495950
155PRKACA0.42428483
156CDK50.42420655
157ABL10.42290141
158INSR0.41176848
159CAMK2G0.38680377
160ADRBK10.38669736
161KDR0.38379847
162IGF1R0.38255385
163TRPM70.38252611
164MAPK120.37976139
165ICK0.34857272
166AKT20.34562779
167NEK20.33237926
168PRKCZ0.31933257
169PRKCD0.30738830
170MAP4K20.30715566
171PDK20.28708019

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046102.62187752
2Ether lipid metabolism_Homo sapiens_hsa005652.62125412
3Pertussis_Homo sapiens_hsa051332.59138946
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.45259751
5Nicotine addiction_Homo sapiens_hsa050332.34141791
6Steroid biosynthesis_Homo sapiens_hsa001002.27312214
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.25121916
8Cell adhesion molecules (CAMs)_Homo sapiens_hsa045142.21227943
9Sphingolipid metabolism_Homo sapiens_hsa006002.19043696
10Oxidative phosphorylation_Homo sapiens_hsa001902.04499036
11Type I diabetes mellitus_Homo sapiens_hsa049402.03828855
12Fatty acid elongation_Homo sapiens_hsa000622.00323882
13Axon guidance_Homo sapiens_hsa043601.97614416
14Serotonergic synapse_Homo sapiens_hsa047261.83334565
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81609862
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.77995375
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.75338720
18Glutamatergic synapse_Homo sapiens_hsa047241.72759093
19Collecting duct acid secretion_Homo sapiens_hsa049661.68027829
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65267502
21Antigen processing and presentation_Homo sapiens_hsa046121.65130181
22Phototransduction_Homo sapiens_hsa047441.63409361
23Taste transduction_Homo sapiens_hsa047421.61381520
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.59003469
25Viral myocarditis_Homo sapiens_hsa054161.58883774
26Rheumatoid arthritis_Homo sapiens_hsa053231.51366684
27Morphine addiction_Homo sapiens_hsa050321.47421408
28Leishmaniasis_Homo sapiens_hsa051401.43342982
29GABAergic synapse_Homo sapiens_hsa047271.37941850
30Alzheimers disease_Homo sapiens_hsa050101.37288858
31Salivary secretion_Homo sapiens_hsa049701.36938404
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.32801275
33Mineral absorption_Homo sapiens_hsa049781.29531377
34Phagosome_Homo sapiens_hsa041451.28954570
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26860805
36Starch and sucrose metabolism_Homo sapiens_hsa005001.26676694
37Long-term depression_Homo sapiens_hsa047301.26474498
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21974024
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.21920923
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.20254889
41Hepatitis C_Homo sapiens_hsa051601.19636776
42ABC transporters_Homo sapiens_hsa020101.18142582
43Chemical carcinogenesis_Homo sapiens_hsa052041.15275917
44Malaria_Homo sapiens_hsa051441.15222870
45African trypanosomiasis_Homo sapiens_hsa051431.14396363
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13546817
47Graft-versus-host disease_Homo sapiens_hsa053321.13362779
48beta-Alanine metabolism_Homo sapiens_hsa004101.11828911
49Toxoplasmosis_Homo sapiens_hsa051451.10337869
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09402259
51Glycosaminoglycan degradation_Homo sapiens_hsa005311.09175039
52Circadian rhythm_Homo sapiens_hsa047101.08766219
53Autoimmune thyroid disease_Homo sapiens_hsa053201.07582018
54Parkinsons disease_Homo sapiens_hsa050121.07104275
55Bile secretion_Homo sapiens_hsa049761.06269366
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.05372100
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02754809
58ECM-receptor interaction_Homo sapiens_hsa045120.99719039
59Vibrio cholerae infection_Homo sapiens_hsa051100.98178974
60Ovarian steroidogenesis_Homo sapiens_hsa049130.97727137
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95188619
62Cholinergic synapse_Homo sapiens_hsa047250.93722849
63Arachidonic acid metabolism_Homo sapiens_hsa005900.93000709
64Influenza A_Homo sapiens_hsa051640.91047461
65Cardiac muscle contraction_Homo sapiens_hsa042600.89493458
66Circadian entrainment_Homo sapiens_hsa047130.89409341
67Calcium signaling pathway_Homo sapiens_hsa040200.89254391
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87539664
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85004303
70Renal cell carcinoma_Homo sapiens_hsa052110.84836816
71Gastric acid secretion_Homo sapiens_hsa049710.84093962
72Allograft rejection_Homo sapiens_hsa053300.84039387
73Tryptophan metabolism_Homo sapiens_hsa003800.83804157
74Renin secretion_Homo sapiens_hsa049240.82455969
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.82076051
76Linoleic acid metabolism_Homo sapiens_hsa005910.81813736
77Cocaine addiction_Homo sapiens_hsa050300.81190694
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80922455
79Huntingtons disease_Homo sapiens_hsa050160.80476377
80Ras signaling pathway_Homo sapiens_hsa040140.79610923
81Protein export_Homo sapiens_hsa030600.78892157
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.77982436
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77832907
84Asthma_Homo sapiens_hsa053100.76169152
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.74967471
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74154638
87Pancreatic secretion_Homo sapiens_hsa049720.73159352
88Oxytocin signaling pathway_Homo sapiens_hsa049210.70927489
89Other glycan degradation_Homo sapiens_hsa005110.70778692
90Phenylalanine metabolism_Homo sapiens_hsa003600.69193651
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68831290
92Focal adhesion_Homo sapiens_hsa045100.68244685
93Protein digestion and absorption_Homo sapiens_hsa049740.67044446
94Basal cell carcinoma_Homo sapiens_hsa052170.65938319
95Histidine metabolism_Homo sapiens_hsa003400.65766439
96Dorso-ventral axis formation_Homo sapiens_hsa043200.64908772
97Melanoma_Homo sapiens_hsa052180.64646419
98Melanogenesis_Homo sapiens_hsa049160.63595194
99Adherens junction_Homo sapiens_hsa045200.63229840
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62961682
101Retinol metabolism_Homo sapiens_hsa008300.62715297
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62391527
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.62123272
104ErbB signaling pathway_Homo sapiens_hsa040120.61928557
105cAMP signaling pathway_Homo sapiens_hsa040240.61417350
106Choline metabolism in cancer_Homo sapiens_hsa052310.60448640
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59738066
108Tuberculosis_Homo sapiens_hsa051520.59296262
109Hedgehog signaling pathway_Homo sapiens_hsa043400.59032219
110Systemic lupus erythematosus_Homo sapiens_hsa053220.58935908
111Tight junction_Homo sapiens_hsa045300.58625380
112Tyrosine metabolism_Homo sapiens_hsa003500.56811723
113GnRH signaling pathway_Homo sapiens_hsa049120.55767809
114Nitrogen metabolism_Homo sapiens_hsa009100.55490333
115Amphetamine addiction_Homo sapiens_hsa050310.55382628
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55106255
117Fatty acid biosynthesis_Homo sapiens_hsa000610.55087652
118Dopaminergic synapse_Homo sapiens_hsa047280.54634107
119Staphylococcus aureus infection_Homo sapiens_hsa051500.54511698
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54058104
121Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53896010
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53656646
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53013824
124Fatty acid degradation_Homo sapiens_hsa000710.52860484
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52646188
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52368928
127TNF signaling pathway_Homo sapiens_hsa046680.51457159
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51355285
129Wnt signaling pathway_Homo sapiens_hsa043100.49490452
130Sulfur metabolism_Homo sapiens_hsa009200.49370921
131Prion diseases_Homo sapiens_hsa050200.48758540
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.47787300
133Salmonella infection_Homo sapiens_hsa051320.47719530
134Proteoglycans in cancer_Homo sapiens_hsa052050.47654963
135Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46957989
136Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45044003
137Hematopoietic cell lineage_Homo sapiens_hsa046400.44757717
138Rap1 signaling pathway_Homo sapiens_hsa040150.44755148
139Endocytosis_Homo sapiens_hsa041440.44393682
140Long-term potentiation_Homo sapiens_hsa047200.43965147
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.43953522
142Leukocyte transendothelial migration_Homo sapiens_hsa046700.43676634
143Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43665616
144Apoptosis_Homo sapiens_hsa042100.42749488
145Lysosome_Homo sapiens_hsa041420.42467154
146Arginine and proline metabolism_Homo sapiens_hsa003300.41882978
147Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41714177
148MAPK signaling pathway_Homo sapiens_hsa040100.41713640
149Gap junction_Homo sapiens_hsa045400.39821167
150Notch signaling pathway_Homo sapiens_hsa043300.38081980
151Herpes simplex infection_Homo sapiens_hsa051680.34725606
152Insulin resistance_Homo sapiens_hsa049310.33974790
153Osteoclast differentiation_Homo sapiens_hsa043800.32700128
154Glutathione metabolism_Homo sapiens_hsa004800.32293852
155Arginine biosynthesis_Homo sapiens_hsa002200.28861496
156Dilated cardiomyopathy_Homo sapiens_hsa054140.26378269
157Maturity onset diabetes of the young_Homo sapiens_hsa049500.24071992

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