SFTA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lung secretory cell differentiation (GO:0061140)9.63584465
2cerebral cortex neuron differentiation (GO:0021895)9.42814857
3forebrain neuron differentiation (GO:0021879)9.30281136
4cellular response to nitric oxide (GO:0071732)6.76663464
5Leydig cell differentiation (GO:0033327)6.22240520
6thyroid gland development (GO:0030878)5.87820505
7positive regulation of circadian rhythm (GO:0042753)5.67974909
8neuron fate commitment (GO:0048663)5.64655982
9negative regulation of complement activation (GO:0045916)5.14484882
10epithelial tube branching involved in lung morphogenesis (GO:0060441)5.14295096
11lung cell differentiation (GO:0060479)4.95123492
12peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.82806620
13cellular response to reactive nitrogen species (GO:1902170)4.82792327
14ganglion development (GO:0061548)4.72831309
15respiratory gaseous exchange (GO:0007585)4.68865339
16lung epithelial cell differentiation (GO:0060487)4.68687145
17negative regulation of epithelial to mesenchymal transition (GO:0010719)4.58345368
18cerebral cortex cell migration (GO:0021795)4.54564298
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.53594446
20thyroid hormone generation (GO:0006590)4.49700050
21negative regulation of protein activation cascade (GO:2000258)4.49003303
22regulation of development, heterochronic (GO:0040034)4.48758012
23response to nitric oxide (GO:0071731)4.47343747
24spinal cord association neuron differentiation (GO:0021527)4.45507940
25nephron tubule development (GO:0072080)4.44409037
26regulation of timing of cell differentiation (GO:0048505)4.38579310
27neuronal stem cell maintenance (GO:0097150)4.29741556
28one-carbon compound transport (GO:0019755)4.26032880
29intraciliary transport (GO:0042073)4.23342278
30negative regulation of humoral immune response (GO:0002921)4.18209232
31left/right axis specification (GO:0070986)4.06771588
32regulation of response to osmotic stress (GO:0047484)4.03079860
33renal tubule development (GO:0061326)3.99904687
34cilium or flagellum-dependent cell motility (GO:0001539)3.88780731
35oligodendrocyte differentiation (GO:0048709)3.74734326
36limb bud formation (GO:0060174)3.69212858
37developmental induction (GO:0031128)3.62528969
38lung lobe morphogenesis (GO:0060463)3.60440619
39nephron epithelium development (GO:0072009)3.59880062
40somite development (GO:0061053)3.58996543
41positive regulation of endothelial cell differentiation (GO:0045603)3.50890404
42endoderm development (GO:0007492)3.46983926
43regulation of vasculogenesis (GO:2001212)3.46718363
44cell-cell signaling involved in cell fate commitment (GO:0045168)3.46129024
45thyroid hormone metabolic process (GO:0042403)3.45486648
46regulation of hippo signaling (GO:0035330)3.45241676
47sympathetic nervous system development (GO:0048485)3.40408021
48pituitary gland development (GO:0021983)3.38884623
49cellular anion homeostasis (GO:0030002)3.38844119
50negative regulation of stem cell differentiation (GO:2000737)3.35779585
51hippocampus development (GO:0021766)3.33708963
52glial cell proliferation (GO:0014009)3.26716235
53lung vasculature development (GO:0060426)3.26113380
54epithelial cilium movement (GO:0003351)3.24132160
55sodium ion homeostasis (GO:0055078)3.20639593
56telencephalon cell migration (GO:0022029)3.19714716
57positive regulation of Notch signaling pathway (GO:0045747)3.14806589
58neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.10734885
59regulation of endothelial cell differentiation (GO:0045601)3.08234868
60negative regulation of oligodendrocyte differentiation (GO:0048715)3.07937805
61trivalent inorganic anion homeostasis (GO:0072506)3.06430509
62phosphate ion homeostasis (GO:0055062)3.06430509
63ectodermal placode formation (GO:0060788)2.97615606
64negative regulation of epidermal cell differentiation (GO:0045605)2.95567111
65DNA double-strand break processing (GO:0000729)2.95204088
66polyol transport (GO:0015791)2.94485939
67pyrimidine nucleobase catabolic process (GO:0006208)2.89795187
68response to folic acid (GO:0051593)2.88814086
69ethanol oxidation (GO:0006069)2.88343304
70regulation of sarcomere organization (GO:0060297)2.88040855
71olfactory bulb development (GO:0021772)2.85414948
72hyperosmotic salinity response (GO:0042538)2.85407710
73forebrain cell migration (GO:0021885)2.85289669
74phosphate ion transmembrane transport (GO:0035435)2.79853837
75macrophage chemotaxis (GO:0048246)2.79797858
76phosphate ion transport (GO:0006817)2.78810325
77dorsal/ventral pattern formation (GO:0009953)2.77606198
78toxin metabolic process (GO:0009404)2.77401710
79cilium movement (GO:0003341)2.77352197
80metanephric nephron tubule development (GO:0072234)2.72351804
81metanephric tubule development (GO:0072170)2.72351804
82reflex (GO:0060004)2.69542870
83regulation of complement activation (GO:0030449)2.68818183
84response to pheromone (GO:0019236)2.68114621
85positive regulation of oligodendrocyte differentiation (GO:0048714)2.66742051
86regulation of oligodendrocyte differentiation (GO:0048713)2.66595980
87positive regulation of vasculogenesis (GO:2001214)2.64287986
88cell fate determination (GO:0001709)2.63673383
89lymphangiogenesis (GO:0001946)2.63662670
90segment specification (GO:0007379)2.63179351
91sequestering of actin monomers (GO:0042989)2.56165307
92peptide catabolic process (GO:0043171)2.53545112
93response to hyperoxia (GO:0055093)2.53088486
94response to increased oxygen levels (GO:0036296)2.53088486
95regulation of epithelial to mesenchymal transition (GO:0010717)2.49725415
96cilium morphogenesis (GO:0060271)2.49208153
97axonemal dynein complex assembly (GO:0070286)2.47978018
98fibroblast migration (GO:0010761)2.47458652
99surfactant homeostasis (GO:0043129)15.1059736
100chemical homeostasis within a tissue (GO:0048875)11.8983263

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.46078764
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.67313691
3CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.47114146
4POU3F2_20337985_ChIP-ChIP_501MEL_Human3.04131933
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.00692963
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.83963863
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.65542955
8IGF1R_20145208_ChIP-Seq_DFB_Human2.54598587
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.52091719
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.51358719
11AR_21572438_ChIP-Seq_LNCaP_Human2.37704039
12FUS_26573619_Chip-Seq_HEK293_Human2.26551380
13TAF15_26573619_Chip-Seq_HEK293_Human2.14286908
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.10722958
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.09060186
16FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.06739823
17AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.06604835
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00937792
19BP1_19119308_ChIP-ChIP_Hs578T_Human1.96257925
20EWS_26573619_Chip-Seq_HEK293_Human1.94062187
21TCF4_18268006_ChIP-ChIP_LS174T_Human1.85169149
22* ZNF274_21170338_ChIP-Seq_K562_Hela1.79615652
23P300_19829295_ChIP-Seq_ESCs_Human1.78834808
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.77626668
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75231006
26FOXM1_26456572_ChIP-Seq_MCF-7_Human1.73835446
27SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72418387
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71378378
29AHR_22903824_ChIP-Seq_MCF-7_Human1.69186793
30VDR_22108803_ChIP-Seq_LS180_Human1.66339457
31SMAD4_21799915_ChIP-Seq_A2780_Human1.65169036
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61099792
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59918859
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.59026084
35ARNT_22903824_ChIP-Seq_MCF-7_Human1.55845474
36NR3C1_21868756_ChIP-Seq_MCF10A_Human1.52851647
37STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.51044961
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49996938
39TAL1_26923725_Chip-Seq_HPCs_Mouse1.44970928
40RNF2_27304074_Chip-Seq_NSC_Mouse1.43587308
41CJUN_26792858_Chip-Seq_BT549_Human1.40424272
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39705138
43RUNX2_22187159_ChIP-Seq_PCA_Human1.38959210
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.37171414
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.36697854
46TP53_18474530_ChIP-ChIP_U2OS_Human1.36600246
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.33634119
48KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33028144
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32894856
50STAT3_23295773_ChIP-Seq_U87_Human1.32634636
51TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.31266753
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31113258
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30363287
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30104855
55CBP_20019798_ChIP-Seq_JUKART_Human1.30104855
56EZH2_22144423_ChIP-Seq_EOC_Human1.28782690
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27021508
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.25057638
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24672675
60* AR_25329375_ChIP-Seq_VCAP_Human1.23491531
61NFIB_24661679_ChIP-Seq_LUNG_Mouse1.22594089
62TCF4_22108803_ChIP-Seq_LS180_Human1.22052621
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20948420
64FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20621281
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20220831
66FLI1_21867929_ChIP-Seq_TH2_Mouse1.17346144
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.15467112
68TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14460415
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13827786
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.13611770
71SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13453340
72KDM2B_26808549_Chip-Seq_REH_Human1.13043901
73SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.12101597
74CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10160597
75ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09934610
76NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09886943
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09886943
78CDX2_22108803_ChIP-Seq_LS180_Human1.09338788
79RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07189040
80TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06148771
81FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03955085
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03758720
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.01675764
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01082339
85PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00571013
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00091892
87BCAT_22108803_ChIP-Seq_LS180_Human0.99999274
88TCF4_23295773_ChIP-Seq_U87_Human0.98723438
89EP300_21415370_ChIP-Seq_HL-1_Mouse0.98555917
90FOXA1_25552417_ChIP-Seq_VCAP_Human0.97851588
91SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.97505364
92LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95741088
93SOX2_21211035_ChIP-Seq_LN229_Gbm0.95199912
94GATA1_22025678_ChIP-Seq_K562_Human0.95165465
95GBX2_23144817_ChIP-Seq_PC3_Human0.94867591
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94164945
97CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93198428
98CDX2_20551321_ChIP-Seq_CACO-2_Human0.92431026
99SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.88844407
100P53_22387025_ChIP-Seq_ESCs_Mouse0.88819225

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence8.82943913
2MP0004782_abnormal_surfactant_physiolog7.56672050
3MP0001958_emphysema4.38503336
4MP0000681_abnormal_thyroid_gland3.47997730
5MP0010368_abnormal_lymphatic_system3.44294473
6MP0003786_premature_aging3.37639207
7MP0008789_abnormal_olfactory_epithelium3.19569035
8MP0005647_abnormal_sex_gland2.76672505
9MP0001177_atelectasis2.71170922
10MP0005499_abnormal_olfactory_system2.64641033
11MP0005394_taste/olfaction_phenotype2.64641033
12MP0002133_abnormal_respiratory_system2.48499045
13MP0005388_respiratory_system_phenotype2.48499045
14MP0008004_abnormal_stomach_pH2.29091475
15MP0003115_abnormal_respiratory_system2.20161244
16MP0004133_heterotaxia2.12995164
17MP0000631_abnormal_neuroendocrine_gland2.08168055
18MP0002234_abnormal_pharynx_morphology2.06833935
19MP0000383_abnormal_hair_follicle1.96955088
20MP0010678_abnormal_skin_adnexa1.82746393
21MP0003119_abnormal_digestive_system1.77653570
22MP0008961_abnormal_basal_metabolism1.66504666
23MP0001879_abnormal_lymphatic_vessel1.55295280
24MP0005645_abnormal_hypothalamus_physiol1.53032739
25MP0005646_abnormal_pituitary_gland1.47297170
26MP0000566_synostosis1.44359172
27MP0005167_abnormal_blood-brain_barrier1.43727121
28MP0009780_abnormal_chondrocyte_physiolo1.42906126
29MP0002102_abnormal_ear_morphology1.34862172
30MP0005253_abnormal_eye_physiology1.30691618
31MP0002653_abnormal_ependyma_morphology1.29262136
32MP0003122_maternal_imprinting1.27126297
33MP0002282_abnormal_trachea_morphology1.20763624
34MP0001542_abnormal_bone_strength1.19163057
35MP0000639_abnormal_adrenal_gland1.18935840
36MP0001986_abnormal_taste_sensitivity1.15254297
37MP0001175_abnormal_lung_morphology1.12949108
38MP0004883_abnormal_blood_vessel1.10968048
39MP0001943_abnormal_respiration1.09902411
40MP0000049_abnormal_middle_ear1.09295179
41MP0005248_abnormal_Harderian_gland1.05252942
42MP0006072_abnormal_retinal_apoptosis1.03698889
43MP0003938_abnormal_ear_development1.03178204
44MP0002638_abnormal_pupillary_reflex1.02590186
45MP0004043_abnormal_pH_regulation0.98912809
46MP0010234_abnormal_vibrissa_follicle0.96137621
47MP0001851_eye_inflammation0.95513741
48MP0000013_abnormal_adipose_tissue0.93773241
49MP0000026_abnormal_inner_ear0.92214195
50MP0000537_abnormal_urethra_morphology0.91139267
51MP0005164_abnormal_response_to0.91058486
52MP0010352_gastrointestinal_tract_polyps0.89613764
53MP0003136_yellow_coat_color0.89539378
54MP0008877_abnormal_DNA_methylation0.89101422
55MP0002108_abnormal_muscle_morphology0.87352021
56MP0001270_distended_abdomen0.87301240
57MP0004085_abnormal_heartbeat0.85592072
58MP0002751_abnormal_autonomic_nervous0.85074184
59MP0002295_abnormal_pulmonary_circulatio0.83917725
60MP0004197_abnormal_fetal_growth/weight/0.80402617
61MP0001984_abnormal_olfaction0.79477722
62MP0000678_abnormal_parathyroid_gland0.75169156
63MP0005595_abnormal_vascular_smooth0.74432540
64MP0005391_vision/eye_phenotype0.73028539
65MP0004272_abnormal_basement_membrane0.72552592
66MP0006054_spinal_hemorrhage0.70876488
67MP0003121_genomic_imprinting0.70647977
68MP0003950_abnormal_plasma_membrane0.68888738
69MP0005503_abnormal_tendon_morphology0.68814244
70MP0005275_abnormal_skin_tensile0.68049203
71MP0002233_abnormal_nose_morphology0.67059001
72MP0006292_abnormal_olfactory_placode0.64422384
73MP0003755_abnormal_palate_morphology0.61810773
74MP0003948_abnormal_gas_homeostasis0.60512822
75MP0001501_abnormal_sleep_pattern0.60151659
76MP0003937_abnormal_limbs/digits/tail_de0.60137342
77MP0000778_abnormal_nervous_system0.58742809
78MP0005083_abnormal_biliary_tract0.58724274
79MP0000462_abnormal_digestive_system0.57811927
80MP0002168_other_aberrant_phenotype0.57577313
81MP0003890_abnormal_embryonic-extraembry0.57249497
82MP0001188_hyperpigmentation0.56283121
83MP0002925_abnormal_cardiovascular_devel0.54439609
84MP0002098_abnormal_vibrissa_morphology0.54052862
85MP0006276_abnormal_autonomic_nervous0.52438516
86MP0005195_abnormal_posterior_eye0.51361640
87MP0000647_abnormal_sebaceous_gland0.51207801
88MP0003137_abnormal_impulse_conducting0.49880832
89MP0001614_abnormal_blood_vessel0.49578518
90MP0003091_abnormal_cell_migration0.48747136
91MP0001286_abnormal_eye_development0.47561757
92MP0001440_abnormal_grooming_behavior0.46658781
93MP0002909_abnormal_adrenal_gland0.46416362
94MP0003787_abnormal_imprinting0.46316406
95MP0002009_preneoplasia0.46120855
96MP0001764_abnormal_homeostasis0.45854757
97MP0006138_congestive_heart_failure0.45686092
98MP0002822_catalepsy0.45464084
99MP0001299_abnormal_eye_distance/0.44635681
100MP0002733_abnormal_thermal_nociception0.43911478

Predicted human phenotypes

RankGene SetZ-score
1Neonatal respiratory distress (HP:0002643)8.23856326
2Respiratory distress (HP:0002098)6.51459898
3Tachypnea (HP:0002789)5.40606840
4Tubulointerstitial fibrosis (HP:0005576)4.93593100
5Hyperpituitarism (HP:0010514)4.31547903
6Goiter (HP:0000853)4.23114603
7Tubulointerstitial abnormality (HP:0001969)3.85169565
8Hyperactive renin-angiotensin system (HP:0000841)3.39997908
9Tubulointerstitial nephritis (HP:0001970)3.39733004
10Abnormality of the fingertips (HP:0001211)3.35514892
11Alveolar cell carcinoma (HP:0006519)2.72431157
12Difficulty walking (HP:0002355)2.65872657
13Neoplasm of the tracheobronchial system (HP:0100552)2.60242035
14Stage 5 chronic kidney disease (HP:0003774)2.60123817
15Pulmonary artery stenosis (HP:0004415)2.57261088
16Nephronophthisis (HP:0000090)2.56795265
17Chronic bronchitis (HP:0004469)2.55893600
18Abnormality of the renal medulla (HP:0100957)2.53455974
19Decreased circulating renin level (HP:0003351)2.49444157
20Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)2.38578085
21Abnormality of the ischium (HP:0003174)2.38542510
22Abnormal respiratory motile cilium morphology (HP:0005938)2.38499825
23Abnormal respiratory epithelium morphology (HP:0012253)2.38499825
24Genital tract atresia (HP:0001827)2.36080660
25Dynein arm defect of respiratory motile cilia (HP:0012255)2.35430366
26Absent/shortened dynein arms (HP:0200106)2.35430366
27Glomerulonephritis (HP:0000099)2.29142240
28Renal salt wasting (HP:0000127)2.26463089
29Vaginal atresia (HP:0000148)2.26179208
30Complement deficiency (HP:0004431)2.25786149
31Asthma (HP:0002099)2.18020566
32Tubular atrophy (HP:0000092)2.13315083
33Renal hypoplasia (HP:0000089)2.11475916
34Dyskinesia (HP:0100660)2.10313993
35Midline defect of the nose (HP:0004122)2.09655476
36Medial flaring of the eyebrow (HP:0010747)2.08225690
37Tented upper lip vermilion (HP:0010804)2.06601504
38Abnormal ciliary motility (HP:0012262)2.05523353
39Hyperkalemia (HP:0002153)2.01203317
40Shawl scrotum (HP:0000049)2.00957020
41Congenital primary aphakia (HP:0007707)2.00242836
42Thyroid-stimulating hormone excess (HP:0002925)13.0318738
43Interstitial pulmonary disease (HP:0006530)11.4447541
44Bicornuate uterus (HP:0000813)1.96645869
45Anxiety (HP:0000739)1.92534551
46Hypothermia (HP:0002045)1.90466197
47Hepatoblastoma (HP:0002884)1.89182656
48Drooling (HP:0002307)1.88089649
49Gait imbalance (HP:0002141)1.87429701
50Morphological abnormality of the middle ear (HP:0008609)1.86475634
51Cutaneous finger syndactyly (HP:0010554)1.86107689
52Hyperaldosteronism (HP:0000859)1.85768692
53Spastic diplegia (HP:0001264)1.80242443
54Aplasia/Hypoplasia of the sternum (HP:0006714)1.79055578
55Intestinal atresia (HP:0011100)1.78622875
56Molar tooth sign on MRI (HP:0002419)1.77658151
57Abnormality of midbrain morphology (HP:0002418)1.77658151
58Submucous cleft hard palate (HP:0000176)1.75950133
59Neoplasm of the lung (HP:0100526)1.75509360
60Agitation (HP:0000713)1.73346868
61Hypoplastic ischia (HP:0003175)1.70882407
62Decreased lacrimation (HP:0000633)1.70593418
63Adactyly (HP:0009776)1.70546818
64Short tibia (HP:0005736)1.70131958
65Excessive salivation (HP:0003781)1.69727296
66True hermaphroditism (HP:0010459)1.69701854
67Abnormality of renin-angiotensin system (HP:0000847)1.69416964
68Neoplasm of the respiratory system (HP:0100606)1.69017845
69Nephrogenic diabetes insipidus (HP:0009806)1.67666818
70Abnormality of the antihelix (HP:0009738)1.67314036
71Exertional dyspnea (HP:0002875)1.66244292
72Systemic lupus erythematosus (HP:0002725)1.65225551
73Down-sloping shoulders (HP:0200021)1.63861793
74Aplasia/Hypoplasia of the tibia (HP:0005772)1.63795586
75Abnormality of chloride homeostasis (HP:0011422)1.62135510
76Pulmonary hypertension (HP:0002092)1.62096148
77Atonic seizures (HP:0010819)1.61556393
78Flat capital femoral epiphysis (HP:0003370)1.61037747
79Long toe (HP:0010511)1.60493201
80Cupped ear (HP:0000378)1.59263424
81Nephritis (HP:0000123)1.58291760
82Camptodactyly of toe (HP:0001836)1.58255704
83Abnormal respiratory motile cilium physiology (HP:0012261)1.58076633
84Gonadotropin excess (HP:0000837)1.57555242
85Abnormality of the renal cortex (HP:0011035)1.56766128
86Abnormality of complement system (HP:0005339)1.56397927
87Abnormality of the labia minora (HP:0012880)1.56301486
88Hypothyroidism (HP:0000821)1.55489334
89Severe Myopia (HP:0011003)1.52709697
90Cortical dysplasia (HP:0002539)1.52635707
91Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.51964204
92Epidermoid cyst (HP:0200040)1.51498356
93Hyperventilation (HP:0002883)1.49710601
94Abnormality of the middle phalanges of the toes (HP:0010183)1.49273618
95Choreoathetosis (HP:0001266)1.47845126
96Absent speech (HP:0001344)1.47752204
97Cutaneous syndactyly (HP:0012725)1.46475001
98Pancreatic cysts (HP:0001737)1.46325577
99Neoplasm of the heart (HP:0100544)1.45093389
100Subacute progressive viral hepatitis (HP:0006572)1.45003008

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCR4.60171615
2CDK193.32953982
3MST1R3.10285806
4LATS12.84392590
5AKT32.59347859
6TIE12.57322493
7STK38L2.56791504
8SRPK12.50276251
9CSNK1A1L2.44981680
10CSNK1G32.33128484
11EPHA32.30494698
12MET2.23757713
13ERBB32.14471253
14CSNK1G12.09626359
15EPHB11.99011410
16CSNK1G21.96349591
17MAP4K21.93290994
18INSRR1.87604425
19MKNK11.85286573
20EPHA41.82158443
21MAPK151.75063298
22TRIM281.72044330
23DAPK21.64867226
24BRSK21.64497925
25NEK91.57356044
26FER1.51905716
27PAK41.50539683
28PLK21.48500482
29MAPK131.46762536
30WNK31.38561707
31FRK1.29859126
32CCNB11.26292059
33CDK61.24337326
34EPHA21.24244900
35UHMK11.23732980
36FGFR21.22456993
37CASK1.21984453
38MAP3K41.07663097
39TGFBR21.02680259
40ERBB20.97692079
41SGK20.85390227
42GRK10.82766864
43LMTK20.80269484
44MAP2K70.76936166
45DYRK1B0.73695273
46YES10.72973400
47CAMKK20.72627770
48BMPR1B0.72252481
49DYRK30.72045945
50SGK2230.71577742
51SGK4940.71577742
52PRKCE0.71222174
53IRAK10.70312428
54PINK10.69450243
55NEK20.68844582
56MARK10.64056690
57CDC42BPA0.62778775
58STK100.62620660
59NME10.59792100
60NUAK10.58759098
61PAK30.58680185
62PTK60.57266156
63LRRK20.57021567
64MARK20.56782124
65MAPK70.56700342
66NLK0.56359681
67FGFR30.54299772
68PDGFRB0.53098901
69CDK30.50964443
70MKNK20.50373598
71CHUK0.49995287
72PRKD10.49099485
73DYRK1A0.45986154
74WEE10.44252233
75CSNK1A10.43934020
76PTK2B0.42882303
77PLK40.41801857
78BRSK10.41408565
79EGFR0.40084139
80STK30.39683373
81MAP3K60.39286836
82NEK60.38867930
83CAMK2B0.38185623
84FGFR40.36179118
85VRK10.36059515
86CSNK1D0.35578286
87RPS6KA40.35074424
88CAMK40.35026897
89SGK30.34592396
90STK390.34106837
91MAPK100.32200214
92ABL10.31701233
93LIMK10.30609709
94RPS6KA50.30201904
95IGF1R0.29679521
96NTRK10.29329828
97AKT20.28162603
98RPS6KA20.28147321
99BRD40.27124115
100TESK10.27025627

Predicted pathways (KEGG)

RankGene SetZ-score
1Circadian rhythm_Homo sapiens_hsa047102.77637950
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.62398361
3Histidine metabolism_Homo sapiens_hsa003402.46252869
4Protein export_Homo sapiens_hsa030602.38873287
5Pertussis_Homo sapiens_hsa051332.36011531
6Complement and coagulation cascades_Homo sapiens_hsa046102.31510740
7ABC transporters_Homo sapiens_hsa020102.25951231
8beta-Alanine metabolism_Homo sapiens_hsa004102.23877443
9ECM-receptor interaction_Homo sapiens_hsa045121.94605606
10Notch signaling pathway_Homo sapiens_hsa043301.92825742
11Ether lipid metabolism_Homo sapiens_hsa005651.88545180
12Taste transduction_Homo sapiens_hsa047421.82574093
13Tryptophan metabolism_Homo sapiens_hsa003801.81173404
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.72236482
15Phototransduction_Homo sapiens_hsa047441.70827066
16Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.70689705
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69628853
18Tight junction_Homo sapiens_hsa045301.68062179
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63719306
20Linoleic acid metabolism_Homo sapiens_hsa005911.59737158
21Phagosome_Homo sapiens_hsa041451.57713770
22Adherens junction_Homo sapiens_hsa045201.57668672
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.55757211
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48007046
25Mineral absorption_Homo sapiens_hsa049781.46017147
26Spliceosome_Homo sapiens_hsa030401.44203123
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.42086011
28Staphylococcus aureus infection_Homo sapiens_hsa051501.41643523
29Hippo signaling pathway_Homo sapiens_hsa043901.36347099
30Lysosome_Homo sapiens_hsa041421.28611862
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.27965830
32Arachidonic acid metabolism_Homo sapiens_hsa005901.25534959
33Propanoate metabolism_Homo sapiens_hsa006401.23482469
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.17873887
35TGF-beta signaling pathway_Homo sapiens_hsa043501.15979946
36Tyrosine metabolism_Homo sapiens_hsa003501.13843364
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12147917
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.11499740
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04818761
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04288910
41Fatty acid degradation_Homo sapiens_hsa000711.03353445
42Hedgehog signaling pathway_Homo sapiens_hsa043401.00561795
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.00490779
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99227647
45Basal cell carcinoma_Homo sapiens_hsa052170.97994829
46mRNA surveillance pathway_Homo sapiens_hsa030150.96291702
47Serotonergic synapse_Homo sapiens_hsa047260.91737082
48Fanconi anemia pathway_Homo sapiens_hsa034600.89313579
49Autoimmune thyroid disease_Homo sapiens_hsa053200.88893549
50Salivary secretion_Homo sapiens_hsa049700.87524035
51Thyroid hormone synthesis_Homo sapiens_hsa049180.81202676
52Nicotine addiction_Homo sapiens_hsa050330.81107368
53Non-homologous end-joining_Homo sapiens_hsa034500.80695322
54GABAergic synapse_Homo sapiens_hsa047270.80073197
55Selenocompound metabolism_Homo sapiens_hsa004500.79036571
56Axon guidance_Homo sapiens_hsa043600.78817232
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78539633
58Asthma_Homo sapiens_hsa053100.78324088
59Sphingolipid metabolism_Homo sapiens_hsa006000.77945032
60Basal transcription factors_Homo sapiens_hsa030220.77809869
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76591669
62Phenylalanine metabolism_Homo sapiens_hsa003600.74965429
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72411580
64Ovarian steroidogenesis_Homo sapiens_hsa049130.69194291
65Chemical carcinogenesis_Homo sapiens_hsa052040.68467541
66Steroid biosynthesis_Homo sapiens_hsa001000.67490358
67Oocyte meiosis_Homo sapiens_hsa041140.65855808
68Focal adhesion_Homo sapiens_hsa045100.64005338
69Butanoate metabolism_Homo sapiens_hsa006500.61640745
70MicroRNAs in cancer_Homo sapiens_hsa052060.60489606
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59959000
72PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58650341
73Glutamatergic synapse_Homo sapiens_hsa047240.58610305
74Retinol metabolism_Homo sapiens_hsa008300.58158677
75Olfactory transduction_Homo sapiens_hsa047400.56205008
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.55965454
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52184680
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52053162
79Peroxisome_Homo sapiens_hsa041460.50146471
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.48245894
81Circadian entrainment_Homo sapiens_hsa047130.48108548
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48039723
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.46847143
84Protein digestion and absorption_Homo sapiens_hsa049740.46560233
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46234794
86Arginine and proline metabolism_Homo sapiens_hsa003300.45781236
87Bile secretion_Homo sapiens_hsa049760.44834166
88Glycerolipid metabolism_Homo sapiens_hsa005610.44768071
89Lysine degradation_Homo sapiens_hsa003100.44448693
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43412264
91Systemic lupus erythematosus_Homo sapiens_hsa053220.43070542
92Thyroid cancer_Homo sapiens_hsa052160.41651492
93Dopaminergic synapse_Homo sapiens_hsa047280.40440278
94Morphine addiction_Homo sapiens_hsa050320.39521828
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39326493
96Renal cell carcinoma_Homo sapiens_hsa052110.38022427
97Proteoglycans in cancer_Homo sapiens_hsa052050.37478565
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37141446
99p53 signaling pathway_Homo sapiens_hsa041150.36550540
100Dilated cardiomyopathy_Homo sapiens_hsa054140.36128447

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