SFTPA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations in this gene are associated with idiopathic pulmonary fibrosis. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to nitric oxide (GO:0071732)7.45408691
2negative regulation of complement activation (GO:0045916)7.34183414
3positive regulation of endothelial cell differentiation (GO:0045603)6.63628062
4negative regulation of protein activation cascade (GO:2000258)6.58212713
5peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)6.57174349
6response to xenobiotic stimulus (GO:0009410)6.41941753
7negative regulation of humoral immune response (GO:0002921)6.07878687
8regulation of endothelial cell differentiation (GO:0045601)6.05688907
9cellular response to reactive nitrogen species (GO:1902170)5.79493770
10lung lobe morphogenesis (GO:0060463)5.63076763
11endothelial tube morphogenesis (GO:0061154)5.58583333
12morphogenesis of an endothelium (GO:0003159)5.58583333
13response to nitric oxide (GO:0071731)5.51613050
14regulation of vasculogenesis (GO:2001212)5.18823040
15dichotomous subdivision of an epithelial terminal unit (GO:0060600)5.04458324
16blood vessel maturation (GO:0001955)4.94718780
17regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00434.87418650
18pattern specification involved in kidney development (GO:0061004)4.83098358
19positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003604.77834266
20phosphate ion transmembrane transport (GO:0035435)4.41414834
21peptide catabolic process (GO:0043171)4.40320703
22lymphangiogenesis (GO:0001946)4.34078839
23induction of positive chemotaxis (GO:0050930)4.20851050
24lung vasculature development (GO:0060426)4.18776169
25trivalent inorganic anion homeostasis (GO:0072506)4.18494614
26phosphate ion homeostasis (GO:0055062)4.18494614
27positive regulation of vasculogenesis (GO:2001214)4.09482881
28one-carbon compound transport (GO:0019755)4.05711680
29establishment of apical/basal cell polarity (GO:0035089)4.03758559
30regulation of complement activation (GO:0030449)3.95267098
31mesodermal cell differentiation (GO:0048333)3.94419678
32cellular anion homeostasis (GO:0030002)3.91263702
33negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.89074897
34negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.86353548
35sodium-independent organic anion transport (GO:0043252)3.85917832
36sodium ion homeostasis (GO:0055078)3.84428836
37cellular hyperosmotic response (GO:0071474)3.83302613
38respiratory tube development (GO:0030323)3.80060607
39virion attachment to host cell (GO:0019062)3.78146389
40adhesion of symbiont to host cell (GO:0044650)3.78146389
41regulation of phospholipid biosynthetic process (GO:0071071)3.71928831
42epithelial tube branching involved in lung morphogenesis (GO:0060441)3.71007181
43regulation of protein activation cascade (GO:2000257)3.65064713
44regulation of interleukin-13 production (GO:0032656)3.63162907
45endocrine hormone secretion (GO:0060986)3.62935315
46artery development (GO:0060840)3.61508720
47hyperosmotic salinity response (GO:0042538)3.61162594
48phosphate ion transport (GO:0006817)3.58335826
49lung alveolus development (GO:0048286)3.54362137
50epithelial cell differentiation involved in prostate gland development (GO:0060742)3.47708746
51neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.47242273
52establishment of monopolar cell polarity (GO:0061162)3.45030962
53establishment or maintenance of monopolar cell polarity (GO:0061339)3.45030962
54regulation of hippo signaling (GO:0035330)3.44912397
55macrophage chemotaxis (GO:0048246)3.40836449
56response to vitamin A (GO:0033189)3.40037615
57iron ion import (GO:0097286)3.39556611
58endocardial cushion development (GO:0003197)3.38849403
59vascular endothelial growth factor signaling pathway (GO:0038084)3.38839701
60* respiratory gaseous exchange (GO:0007585)3.38785297
61cellular response to antibiotic (GO:0071236)3.31432454
62response to hyperoxia (GO:0055093)3.31281880
63response to increased oxygen levels (GO:0036296)3.31281880
64cellular response to thyroid hormone stimulus (GO:0097067)3.30129512
65negative regulation of interleukin-2 production (GO:0032703)3.30129414
66complement activation (GO:0006956)3.30125652
67icosanoid transport (GO:0071715)3.30078216
68fatty acid derivative transport (GO:1901571)3.30078216
69complement activation, classical pathway (GO:0006958)3.29621688
70regulation of glomerular filtration (GO:0003093)3.27180218
71renal absorption (GO:0070293)3.26723740
72protein localization to endosome (GO:0036010)3.26139187
73hormone catabolic process (GO:0042447)3.24611650
74endothelial cell differentiation (GO:0045446)3.21989723
75cell adhesion mediated by integrin (GO:0033627)3.20116536
76adhesion of symbiont to host (GO:0044406)3.19576423
77response to interleukin-6 (GO:0070741)3.19468055
78lung secretory cell differentiation (GO:0061140)3.18883829
79norepinephrine metabolic process (GO:0042415)3.16675025
80embryonic foregut morphogenesis (GO:0048617)3.10218362
81regulation of integrin-mediated signaling pathway (GO:2001044)3.08263696
82negative regulation of response to reactive oxygen species (GO:1901032)3.08248497
83renal filtration (GO:0097205)3.08047758
84toxin metabolic process (GO:0009404)3.06542151
85hydrogen peroxide biosynthetic process (GO:0050665)3.05019525
86polarized epithelial cell differentiation (GO:0030859)3.04867139
87regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.02519607
88sphingosine metabolic process (GO:0006670)3.01774930
89positive regulation of p38MAPK cascade (GO:1900745)2.99926986
90phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.99781707
91ethanol oxidation (GO:0006069)2.98060990
92cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.97916301
93hemidesmosome assembly (GO:0031581)2.96162133
94wound healing, spreading of epidermal cells (GO:0035313)2.95695821
95lymph vessel development (GO:0001945)2.93942118
96positive regulation of digestive system process (GO:0060456)2.93766920
97membrane raft organization (GO:0031579)2.92935223
98endothelial cell chemotaxis (GO:0035767)2.92250021
99branching involved in salivary gland morphogenesis (GO:0060445)2.89043089
100blood vessel remodeling (GO:0001974)2.87011943
101glomerular epithelial cell development (GO:0072310)2.85996734
102neuron remodeling (GO:0016322)2.85517127
103negative regulation of stress fiber assembly (GO:0051497)2.82366863
104protein activation cascade (GO:0072376)2.79801582
105extracellular matrix assembly (GO:0085029)2.76777166
106polyol transport (GO:0015791)2.74946440
107apoptotic cell clearance (GO:0043277)2.72520488
108retina vasculature morphogenesis in camera-type eye (GO:0061299)2.71686940
109membrane protein proteolysis (GO:0033619)2.70753889
110establishment of epithelial cell polarity (GO:0090162)2.69986855
111reactive oxygen species biosynthetic process (GO:1903409)2.67361913
112renal system process involved in regulation of blood volume (GO:0001977)2.65072250
113negative regulation of actin filament bundle assembly (GO:0032232)2.63561394
114columnar/cuboidal epithelial cell development (GO:0002066)2.60539276
115negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.59675118
116diol metabolic process (GO:0034311)2.58865368
117cell migration involved in sprouting angiogenesis (GO:0002042)2.57245152
118multicellular organismal water homeostasis (GO:0050891)2.56175102
119gas transport (GO:0015669)2.55365703
120midgut development (GO:0007494)2.55282588
121interleukin-6-mediated signaling pathway (GO:0070102)2.55030933
122glomerular filtration (GO:0003094)2.55013026
123import into cell (GO:0098657)2.54772511
124regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.54739022
125regulation of interleukin-5 production (GO:0032674)2.53018539
126regulation of cholesterol storage (GO:0010885)2.52861137
127negative regulation of adherens junction organization (GO:1903392)2.52596657
128negative regulation of focal adhesion assembly (GO:0051895)2.52596657
129negative regulation of cell junction assembly (GO:1901889)2.52596657
130toxin transport (GO:1901998)2.52310062
131positive regulation of positive chemotaxis (GO:0050927)2.51817328
132positive regulation of phagocytosis (GO:0050766)2.51570740
133negative regulation of alcohol biosynthetic process (GO:1902931)2.51407583
134negative regulation of T cell proliferation (GO:0042130)2.50495938
135regulation of smooth muscle cell differentiation (GO:0051150)2.50326889
136Leydig cell differentiation (GO:0033327)2.50222141
137establishment of endothelial barrier (GO:0061028)2.48473826
138angiotensin maturation (GO:0002003)2.48237103
139negative regulation of endothelial cell proliferation (GO:0001937)2.47965180
140regulation of axon extension involved in axon guidance (GO:0048841)2.47877227
141regulation of p38MAPK cascade (GO:1900744)2.47465407
142renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.47124253
143basement membrane organization (GO:0071711)2.47033588
144atrioventricular valve morphogenesis (GO:0003181)2.45729799
145T cell mediated immunity (GO:0002456)2.45048829
146fibroblast migration (GO:0010761)2.43916080
147intestinal epithelial cell development (GO:0060576)2.43716663
148cellular sodium ion homeostasis (GO:0006883)2.43063708
149positive regulation of chemokine secretion (GO:0090197)2.41897305
150regulation of positive chemotaxis (GO:0050926)2.40033542
151response to thyroid hormone (GO:0097066)2.40000799
152complement activation, alternative pathway (GO:0006957)2.39709184
153ethanol metabolic process (GO:0006067)2.37394719
154cell volume homeostasis (GO:0006884)2.37024795
155regulation of macrophage chemotaxis (GO:0010758)2.36478551
156icosanoid secretion (GO:0032309)2.36380417
157surfactant homeostasis (GO:0043129)18.1195726
158chemical homeostasis within a tissue (GO:0048875)14.4878660

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human6.15825792
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.66387812
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.37873178
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.12515953
5CLOCK_20551151_ChIP-Seq_293T_Human3.00959876
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.79656418
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.79074187
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.74458543
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.53670230
10GATA2_21666600_ChIP-Seq_HMVEC_Human2.51164944
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.49770804
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.41050143
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.31091077
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.17815647
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.05638482
16TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.04327053
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.03588836
18SOX2_20726797_ChIP-Seq_SW620_Human1.97206165
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95024947
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.94587828
21AHR_22903824_ChIP-Seq_MCF-7_Human1.81798511
22CDX2_20551321_ChIP-Seq_CACO-2_Human1.81299719
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.81093263
24FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.77624434
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70605371
26PPAR_26484153_Chip-Seq_NCI-H1993_Human1.69283490
27SALL4_18804426_ChIP-ChIP_XEN_Mouse1.63346156
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.62929234
29SOX2_27498859_Chip-Seq_STOMACH_Mouse1.62176196
30BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.59395001
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.57600611
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55450419
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54970960
34ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.53369794
35TBX20_22328084_ChIP-Seq_HEART_Mouse1.52611382
36TBX20_22080862_ChIP-Seq_HEART_Mouse1.52611382
37ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.52540767
38SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.51624585
39TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50715869
40EP300_21415370_ChIP-Seq_HL-1_Mouse1.50392550
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.50201796
42* LXR_22158963_ChIP-Seq_LIVER_Mouse1.49452238
43NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.49437815
44CJUN_26792858_Chip-Seq_BT549_Human1.48188676
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47685977
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.45466571
47GATA4_25053715_ChIP-Seq_YYC3_Human1.43725762
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.43518401
49RACK7_27058665_Chip-Seq_MCF-7_Human1.43026108
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.40504578
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.40462197
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40330821
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.37931644
54CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.37334071
55TP53_18474530_ChIP-ChIP_U2OS_Human1.36377257
56SOX9_24532713_ChIP-Seq_HFSC_Mouse1.36015765
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.35857994
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34642195
59SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33877084
60RUNX1_27514584_Chip-Seq_MCF-7_Human1.32164687
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29747936
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29588130
63IRF8_21731497_ChIP-ChIP_J774_Mouse1.29228576
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28266403
65EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24327262
66AR_21572438_ChIP-Seq_LNCaP_Human1.24188420
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22341855
68RXR_22158963_ChIP-Seq_LIVER_Mouse1.21936855
69NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.21033452
70NFIB_24661679_ChIP-Seq_LUNG_Mouse1.18605490
71CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18472051
72RUNX_20019798_ChIP-Seq_JUKART_Human1.17383259
73GATA1_19941826_ChIP-Seq_K562_Human1.17344074
74JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17114725
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14250800
76FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.13933523
77ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12299803
78SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12042380
79SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12042380
80SMAD3_21741376_ChIP-Seq_HESCs_Human1.11588050
81NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11510164
82SPI1_23127762_ChIP-Seq_K562_Human1.09407292
83PPARA_22158963_ChIP-Seq_LIVER_Mouse1.09253136
84KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09136826
85STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09130754
86HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08682153
87IRF8_22096565_ChIP-ChIP_GC-B_Human1.08499845
88CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08212895
89ZNF263_19887448_ChIP-Seq_K562_Human1.07713079
90KDM2B_26808549_Chip-Seq_K562_Human1.07697056
91FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06964323
92VDR_24787735_ChIP-Seq_THP-1_Human1.06028968
93SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.04350073
94TP63_17297297_ChIP-ChIP_HaCaT_Human1.04060592
95AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.03818423
96MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02022243
97PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01637928
98ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01398702
99IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00930402
100FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99945712
101FOXA2_19822575_ChIP-Seq_HepG2_Human0.99856163
102MYB_21317192_ChIP-Seq_ERMYB_Mouse0.99252348
103KLF5_25053715_ChIP-Seq_YYC3_Human0.99121223
104LXR_22292898_ChIP-Seq_THP-1_Human0.98974486
105NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98824086
106P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98617717
107WT1_19549856_ChIP-ChIP_CCG9911_Human0.95036864
108RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93395210
109CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92996281
110WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92917529
111SMAD4_21741376_ChIP-Seq_HESCs_Human0.91926556
112ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91717475
113GATA3_24758297_ChIP-Seq_MCF-7_Human0.91582641
114GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90959258
115IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90096352
116JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89542778
117TCF4_18268006_ChIP-ChIP_LS174T_Human0.89248681
118NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89215088
119NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89215088
120GATA6_25053715_ChIP-Seq_YYC3_Human0.88866301
121SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.88554205
122P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88343487
123ISL1_27105846_Chip-Seq_CPCs_Mouse0.86704419
124PIAS1_25552417_ChIP-Seq_VCAP_Human0.86689978
125SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.86305697
126TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86040869
127GATA2_19941826_ChIP-Seq_K562_Human0.85644623
128SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.85573803
129TP63_23658742_ChIP-Seq_EP156T_Human0.85288180

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0004782_abnormal_surfactant_physiolog7.83898881
2MP0001958_emphysema6.83717716
3MP0008995_early_reproductive_senescence4.73896826
4MP0010368_abnormal_lymphatic_system4.13851353
5MP0002138_abnormal_hepatobiliary_system3.81234981
6MP0005083_abnormal_biliary_tract3.77219244
7MP0001542_abnormal_bone_strength3.44322058
8MP0008004_abnormal_stomach_pH3.37352639
9MP0003724_increased_susceptibility_to3.15319146
10MP0001879_abnormal_lymphatic_vessel3.07272113
11MP0005167_abnormal_blood-brain_barrier3.04177387
12MP0001177_atelectasis2.84129426
13MP0002295_abnormal_pulmonary_circulatio2.61576644
14MP0002132_abnormal_respiratory_system2.59168194
15* MP0005388_respiratory_system_phenotype2.57090858
16* MP0002133_abnormal_respiratory_system2.57090858
17MP0003191_abnormal_cellular_cholesterol2.52894367
18MP0000537_abnormal_urethra_morphology2.23978421
19MP0004272_abnormal_basement_membrane1.96288152
20MP0008875_abnormal_xenobiotic_pharmacok1.94225838
21MP0000566_synostosis1.83797237
22MP0002277_abnormal_respiratory_mucosa1.80664111
23MP0010234_abnormal_vibrissa_follicle1.73083199
24MP0009780_abnormal_chondrocyte_physiolo1.65908297
25MP0003566_abnormal_cell_adhesion1.62794279
26MP0003690_abnormal_glial_cell1.58457986
27MP0005058_abnormal_lysosome_morphology1.54454409
28MP0001440_abnormal_grooming_behavior1.52158382
29MP0002998_abnormal_bone_remodeling1.45993772
30MP0000343_altered_response_to1.39348060
31* MP0001175_abnormal_lung_morphology1.34654161
32MP0003950_abnormal_plasma_membrane1.30533029
33MP0010352_gastrointestinal_tract_polyps1.24094674
34MP0005275_abnormal_skin_tensile1.22028005
35MP0005164_abnormal_response_to1.18753796
36MP0004883_abnormal_blood_vessel1.17907769
37MP0000767_abnormal_smooth_muscle1.17804137
38MP0000249_abnormal_blood_vessel1.17008025
39MP0005595_abnormal_vascular_smooth1.15942655
40MP0001851_eye_inflammation1.15676956
41MP0003115_abnormal_respiratory_system1.14649279
42MP0005408_hypopigmentation1.14404354
43MP0000465_gastrointestinal_hemorrhage1.14129384
44MP0002139_abnormal_hepatobiliary_system1.14014577
45MP0003303_peritoneal_inflammation1.12593659
46MP0001545_abnormal_hematopoietic_system1.11350201
47MP0005397_hematopoietic_system_phenotyp1.11350201
48MP0000534_abnormal_ureter_morphology1.08272515
49MP0003786_premature_aging1.07573763
50MP0003279_aneurysm1.06752038
51MP0002877_abnormal_melanocyte_morpholog1.05745391
52MP0006138_congestive_heart_failure1.00897150
53MP0003705_abnormal_hypodermis_morpholog1.00421295
54MP0003091_abnormal_cell_migration1.00062175
55MP0006054_spinal_hemorrhage0.98708864
56MP0005166_decreased_susceptibility_to0.95259188
57MP0005023_abnormal_wound_healing0.93302542
58MP0002419_abnormal_innate_immunity0.92212314
59MP0008438_abnormal_cutaneous_collagen0.90497629
60MP0003300_gastrointestinal_ulcer0.88957942
61MP0010678_abnormal_skin_adnexa0.87626489
62MP0005085_abnormal_gallbladder_physiolo0.87231633
63MP0005503_abnormal_tendon_morphology0.86837829
64MP0000013_abnormal_adipose_tissue0.86590096
65MP0002166_altered_tumor_susceptibility0.84919074
66MP0003656_abnormal_erythrocyte_physiolo0.84134886
67MP0009840_abnormal_foam_cell0.83122146
68MP0001986_abnormal_taste_sensitivity0.82633144
69MP0003075_altered_response_to0.81247718
70MP0000462_abnormal_digestive_system0.81177166
71MP0002332_abnormal_exercise_endurance0.80102233
72MP0002909_abnormal_adrenal_gland0.79551432
73MP0003828_pulmonary_edema0.78207110
74MP0002733_abnormal_thermal_nociception0.77914675
75MP0010329_abnormal_lipoprotein_level0.77833405
76MP0002796_impaired_skin_barrier0.77542524
77MP0004185_abnormal_adipocyte_glucose0.77056213
78MP0004947_skin_inflammation0.76729103
79MP0002098_abnormal_vibrissa_morphology0.76681072
80MP0000604_amyloidosis0.76353427
81MP0003453_abnormal_keratinocyte_physiol0.75890646
82MP0003448_altered_tumor_morphology0.75639567
83MP0002128_abnormal_blood_circulation0.73877933
84MP0001533_abnormal_skeleton_physiology0.72544937
85MP0002925_abnormal_cardiovascular_devel0.70997911
86MP0006082_CNS_inflammation0.70734440
87* MP0005025_abnormal_response_to0.68209060
88MP0001501_abnormal_sleep_pattern0.68060642
89MP0002168_other_aberrant_phenotype0.67273570
90MP0001666_abnormal_nutrient_absorption0.66808590
91* MP0001943_abnormal_respiration0.66654007
92MP0002282_abnormal_trachea_morphology0.66541133
93MP0005165_increased_susceptibility_to0.65106350
94MP0001664_abnormal_digestion0.64776527
95MP0004484_altered_response_of0.64631005
96MP0004084_abnormal_cardiac_muscle0.64620998
97MP0001614_abnormal_blood_vessel0.64589740
98MP0009764_decreased_sensitivity_to0.63314101
99MP0005387_immune_system_phenotype0.63174005
100MP0001790_abnormal_immune_system0.63174005
101MP0002009_preneoplasia0.62791427
102MP0001544_abnormal_cardiovascular_syste0.62247656
103MP0005385_cardiovascular_system_phenoty0.62247656
104MP0009643_abnormal_urine_homeostasis0.61804631
105MP0000685_abnormal_immune_system0.61330750
106* MP0002118_abnormal_lipid_homeostasis0.60492151
107MP0004085_abnormal_heartbeat0.60183300
108MP0004510_myositis0.59446748
109MP0002136_abnormal_kidney_physiology0.59051653
110MP0000383_abnormal_hair_follicle0.58633845
111MP0001853_heart_inflammation0.58180595
112MP0003638_abnormal_response/metabolism_0.57901152
113MP0008775_abnormal_heart_ventricle0.57317879
114MP0001661_extended_life_span0.56993176
115MP0005332_abnormal_amino_acid0.56284910
116MP0003045_fibrosis0.55948486
117MP0005647_abnormal_sex_gland0.53265559
118MP0003795_abnormal_bone_structure0.52550368
119MP0008961_abnormal_basal_metabolism0.52307870
120MP0001346_abnormal_lacrimal_gland0.52117150
121MP0005464_abnormal_platelet_physiology0.52029007
122MP0002135_abnormal_kidney_morphology0.51185263
123MP0001756_abnormal_urination0.50284461
124MP0000920_abnormal_myelination0.49681566
125MP0009384_cardiac_valve_regurgitation0.49423066
126MP0003329_amyloid_beta_deposits0.48197495
127MP0002234_abnormal_pharynx_morphology0.47664081
128* MP0002405_respiratory_system_inflammati0.47256230
129MP0001765_abnormal_ion_homeostasis0.47198428
130MP0004130_abnormal_muscle_cell0.46926118
131MP0000627_abnormal_mammary_gland0.46761954
132MP0000681_abnormal_thyroid_gland0.46712253
133MP0003436_decreased_susceptibility_to0.46588292
134MP0004885_abnormal_endolymph0.45776996

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)7.03154801
2Hyperactive renin-angiotensin system (HP:0000841)6.87795809
3Tubulointerstitial fibrosis (HP:0005576)6.56391273
4Chronic bronchitis (HP:0004469)6.14687740
5Tachypnea (HP:0002789)6.05988950
6Alveolar cell carcinoma (HP:0006519)5.93377262
7Systemic lupus erythematosus (HP:0002725)5.53542453
8Polycythemia (HP:0001901)5.53242218
9Neoplasm of the tracheobronchial system (HP:0100552)5.53133115
10Renal salt wasting (HP:0000127)5.50709160
11Respiratory distress (HP:0002098)5.39350067
12Hematochezia (HP:0002573)5.00710038
13Exertional dyspnea (HP:0002875)4.96028529
14Glomerulonephritis (HP:0000099)4.64504537
15Abnormality of the nasal mucosa (HP:0000433)4.54662654
16Gout (HP:0001997)4.41038432
17Spontaneous hematomas (HP:0007420)4.39695289
18Hyperkalemia (HP:0002153)4.22708096
19Neurofibrillary tangles (HP:0002185)4.13890810
20Abnormality of complement system (HP:0005339)3.79714392
21Visceral angiomatosis (HP:0100761)3.77217154
22Tubulointerstitial abnormality (HP:0001969)3.76141580
23Onycholysis (HP:0001806)3.57902459
24Pulmonary fibrosis (HP:0002206)3.52337781
25Hemangiomatosis (HP:0007461)3.51088576
26Ulnar bowing (HP:0003031)3.44193831
27Hypergammaglobulinemia (HP:0010702)3.31997634
28Cerebral inclusion bodies (HP:0100314)3.31960185
29Esophageal varix (HP:0002040)3.25632747
30Hyperaldosteronism (HP:0000859)3.21516338
31Bronchitis (HP:0012387)3.11754485
32Tubulointerstitial nephritis (HP:0001970)3.11358178
33Hypotension (HP:0002615)3.06723656
34Broad metatarsal (HP:0001783)3.05430737
35Chronic otitis media (HP:0000389)2.97762251
36Neoplasm of the lung (HP:0100526)2.96508371
37Abnormality of chloride homeostasis (HP:0011422)2.96148791
38Long toe (HP:0010511)2.92492755
39Conjunctival telangiectasia (HP:0000524)2.89337321
40Segmental peripheral demyelination/remyelination (HP:0003481)2.88751822
41Abnormal umbilical cord blood vessels (HP:0011403)2.85262288
42Single umbilical artery (HP:0001195)2.85262288
43Abnormality of the fetal cardiovascular system (HP:0010948)2.85262288
44Abnormality of renin-angiotensin system (HP:0000847)2.81274789
45Decreased circulating renin level (HP:0003351)2.78405273
46Potter facies (HP:0002009)2.69626030
47Facial shape deformation (HP:0011334)2.69626030
48Supranuclear gaze palsy (HP:0000605)2.64245667
49Osteolytic defects of the phalanges of the hand (HP:0009771)2.63382478
50Osteolytic defects of the hand bones (HP:0009699)2.63382478
51Cerebral hemorrhage (HP:0001342)2.63048287
52Cerebral aneurysm (HP:0004944)2.62348908
53Neoplasm of the respiratory system (HP:0100606)2.59185491
54Abnormality of the vasculature of the conjunctiva (HP:0008054)2.56325694
55Pulmonary hypertension (HP:0002092)2.51762422
56Growth hormone excess (HP:0000845)2.50090536
57Loss of speech (HP:0002371)2.45028071
58Vascular tortuosity (HP:0004948)2.44993270
59Bronchomalacia (HP:0002780)2.43970111
60Deep venous thrombosis (HP:0002625)2.41905549
61Ulnar claw (HP:0001178)2.41405081
62Neonatal respiratory distress (HP:0002643)2.38993810
63Hyponatremia (HP:0002902)2.34884318
64Prostate neoplasm (HP:0100787)2.34331129
65Bowing of the arm (HP:0006488)2.33959315
66Bowed forearm bones (HP:0003956)2.33959315
67Tubular atrophy (HP:0000092)2.31458766
68Recurrent gram-negative bacterial infections (HP:0005420)2.26473969
69Stomach cancer (HP:0012126)2.24753993
70Hypokalemic alkalosis (HP:0001949)2.22441418
71Thyroid-stimulating hormone excess (HP:0002925)2.19151622
72Glucose intolerance (HP:0000833)2.16808044
73Arterial tortuosity (HP:0005116)2.15800632
74Cavernous hemangioma (HP:0001048)2.10197647
75Increased CSF protein (HP:0002922)2.09514254
76Fragile nails (HP:0001808)2.07799754
77Eczematoid dermatitis (HP:0000976)2.04468688
78Microcytic anemia (HP:0001935)2.04383076
79Pulmonary artery stenosis (HP:0004415)2.03818819
80Interstitial pulmonary disease (HP:0006530)13.6159791
81Glomerulosclerosis (HP:0000096)1.98932087
82Subacute progressive viral hepatitis (HP:0006572)1.98686478
83Rapidly progressive (HP:0003678)1.97630629
84Restrictive lung disease (HP:0002091)1.97088977
85Striae distensae (HP:0001065)1.96891620
86Shallow orbits (HP:0000586)1.96503690
87Distal lower limb muscle weakness (HP:0009053)1.96397623
88Complement deficiency (HP:0004431)1.95681846
89Atrophic scars (HP:0001075)1.95548712
90Stenosis of the external auditory canal (HP:0000402)1.94933894
91Bronchiectasis (HP:0002110)1.94459505
92Rectal prolapse (HP:0002035)1.94328916
93Annular pancreas (HP:0001734)1.93662845
94Hyperpituitarism (HP:0010514)1.92841121
95Abnormality of macrophages (HP:0004311)1.91469969
96Intestinal atresia (HP:0011100)1.89977316
97Synostosis involving the elbow (HP:0003938)1.89579726
98Humeroradial synostosis (HP:0003041)1.89579726
99Recurrent abscess formation (HP:0002722)1.89427355
100Megalencephaly (HP:0001355)1.89200815
101Abnormality of sodium homeostasis (HP:0010931)1.88454282
102Adrenal overactivity (HP:0002717)1.87473953
103Increased purine levels (HP:0004368)1.86209310
104Hyperuricemia (HP:0002149)1.86209310
105Milia (HP:0001056)1.84022672
106Shawl scrotum (HP:0000049)1.83451735
107Skin nodule (HP:0200036)1.82876928
108Aplasia of the phalanges of the hand (HP:0009802)1.82789458
109Aplasia involving bones of the extremities (HP:0009825)1.82789458
110Aplasia involving bones of the upper limbs (HP:0009823)1.82789458
111Joint swelling (HP:0001386)1.80592272
112Camptodactyly of toe (HP:0001836)1.80185944
113Mucosal telangiectasiae (HP:0100579)1.77398927
114Abnormality of the pulmonary veins (HP:0011718)1.77105913
115Pustule (HP:0200039)1.75705695
116Partial duplication of thumb phalanx (HP:0009944)1.74837798
117Thickened helices (HP:0000391)1.72675300
118Nasal polyposis (HP:0100582)1.71106622
119Urinary glycosaminoglycan excretion (HP:0003541)1.63895214
120Mucopolysacchariduria (HP:0008155)1.63895214
121Turricephaly (HP:0000262)1.63391927
122Plantar hyperkeratosis (HP:0007556)1.62183891
123Split foot (HP:0001839)1.60691750
124Wormian bones (HP:0002645)1.58727018
125Myocardial infarction (HP:0001658)1.58310132
126Abnormality of glycolipid metabolism (HP:0010969)1.57665928
127Abnormality of liposaccharide metabolism (HP:0010968)1.57665928
128Abnormality of glycosphingolipid metabolism (HP:0004343)1.57665928
129Aortic aneurysm (HP:0004942)1.57285090
130Abnormality of purine metabolism (HP:0004352)1.56239531
131Nephritis (HP:0000123)1.55642752
132Abnormality of the umbilical cord (HP:0010881)1.55180607
133Abnormal glucose tolerance (HP:0001952)1.55067032
134Abnormality of polysaccharide metabolism (HP:0011012)1.52951984
135Abnormality of glycosaminoglycan metabolism (HP:0004371)1.52951984
136Abnormality of mucopolysaccharide metabolism (HP:0011020)1.52951984
137Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.50903921
138Joint contractures involving the joints of the feet (HP:0100492)1.50061297
139Flexion contracture of toe (HP:0005830)1.50061297
140Aneurysm (HP:0002617)1.48628404
141Seborrheic dermatitis (HP:0001051)1.48228906
142Abnormality of the periventricular white matter (HP:0002518)1.46211930
143Aortic dissection (HP:0002647)1.45300532
144Abnormality of the prostate (HP:0008775)1.43746264
145Onion bulb formation (HP:0003383)1.43186941
146Purpura (HP:0000979)1.43040323
147Mitral valve prolapse (HP:0001634)1.42518055
148Increased connective tissue (HP:0009025)1.42432032
149Reduced subcutaneous adipose tissue (HP:0003758)1.39920356
150Mitral stenosis (HP:0001718)1.36000935
151Absent hand (HP:0004050)1.34769856
152Atrioventricular block (HP:0001678)1.34001891
153Adactyly (HP:0009776)1.33779384
154Difficulty walking (HP:0002355)1.33214044
155Increased cerebral lipofuscin (HP:0011813)1.31629287
156Gingivitis (HP:0000230)1.29838894

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.35962098
2FGFR24.43785026
3TGFBR23.94860632
4LRRK23.28026636
5STK243.15218692
6PAK42.64198805
7EPHB22.51843913
8ZAP702.51679188
9LMTK22.37075954
10TRIB32.36624320
11EPHB12.28440561
12DAPK22.27013172
13GRK12.08731427
14RIPK12.04821251
15FGFR41.95079915
16PRPF4B1.83247728
17MST41.82596888
18FER1.80919058
19CDC42BPA1.80589925
20ILK1.79961914
21NLK1.79146054
22PDGFRB1.78796639
23STK101.75121126
24MAP3K141.69697302
25MAP3K31.66260594
26ERN11.58770053
27EPHA21.54609606
28MYLK1.53083251
29MAP3K21.51299389
30MAP3K61.50899686
31STK38L1.50149876
32LATS21.44749588
33MST1R1.43930853
34IRAK11.42333800
35TESK11.41429540
36MAP3K131.37230482
37PTK61.36080466
38PDGFRA1.26859304
39TGFBR11.19052963
40KSR21.17578265
41KDR1.14778885
42YES11.14623425
43TRPM71.13864491
44MAPK151.11207173
45EPHA31.09603978
46FGFR31.08351721
47CSK1.07168009
48MET1.07159288
49MAPK71.05193473
50AKT31.02786569
51CAMK1D0.98497676
52MAPK120.94783753
53GSK3A0.93548752
54LIMK10.91233486
55CDK60.90865135
56SGK20.88308950
57TAOK30.88048830
58PTK2B0.84517094
59PRKD10.83173922
60PDK20.82233531
61EGFR0.81063551
62MAP3K90.78831456
63KIT0.78599122
64MAP2K30.77991039
65SIK10.73710476
66MAP3K120.71733012
67LATS10.70457220
68PTK20.68326887
69MAP3K70.67469674
70ERBB40.67369179
71TTN0.66556560
72DDR20.65953434
73SGK2230.61534006
74SGK4940.61534006
75NEK90.61082688
76NTRK10.60432120
77PRKG20.58532383
78PDPK10.58229611
79JAK10.58135265
80TYK20.57748264
81PKN20.56378161
82NTRK30.56353133
83DAPK10.56218206
84DAPK30.55523053
85MAP3K10.55315666
86NEK60.54858850
87MATK0.53672855
88PRKCH0.51888944
89FGFR10.51546481
90MAPKAPK20.51434840
91MAP2K20.51388852
92STK380.51059249
93PRKCQ0.50712319
94INSR0.50700735
95RPS6KL10.49605549
96RPS6KC10.49605549
97CAMK1G0.47669114
98MTOR0.47281640
99GRK70.45615785
100ERBB30.45097677
101MAP2K10.43027080
102TBK10.41690158
103ROCK20.41683789
104BLK0.40535667
105MAPK30.40477483
106BMX0.40270192
107DMPK0.39870972
108MAP4K10.39830069
109PDK10.39424713
110TEC0.39157382
111ERBB20.38464562
112MARK20.38260719
113RET0.38106588
114MAPK40.37276351
115GRK50.36931603
116MELK0.36877871
117MOS0.36851005
118FGR0.36303453
119ROCK10.36013800
120RPS6KA60.35691773
121BCR0.35629587
122ABL10.33531760
123RPS6KA40.33188317
124MAPK10.33036658
125FES0.32963223
126HIPK20.32823989
127RPS6KA50.32117223
128PRKCE0.29809766
129IGF1R0.29644380
130FYN0.29145856
131TYRO30.29069127
132JAK20.28604173
133SGK30.28439625
134WNK40.27264031
135IKBKE0.27069051
136SRC0.25508641
137PRKCD0.25068704
138MAP3K110.22609739
139RPS6KA20.22037574

Predicted pathways (KEGG)

RankGene SetZ-score
1Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049603.27777859
2Mineral absorption_Homo sapiens_hsa049782.86974872
3Caffeine metabolism_Homo sapiens_hsa002322.63960671
4ECM-receptor interaction_Homo sapiens_hsa045122.54592421
5Lysosome_Homo sapiens_hsa041422.29614107
6Adherens junction_Homo sapiens_hsa045202.19917920
7Leukocyte transendothelial migration_Homo sapiens_hsa046702.12711818
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.95324703
9Tight junction_Homo sapiens_hsa045301.89543928
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.86112439
11Asthma_Homo sapiens_hsa053101.85510405
12Fatty acid biosynthesis_Homo sapiens_hsa000611.81900342
13Focal adhesion_Homo sapiens_hsa045101.74349122
14Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.67081223
15Graft-versus-host disease_Homo sapiens_hsa053321.59394993
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.56288390
17Allograft rejection_Homo sapiens_hsa053301.55946558
18Renin-angiotensin system_Homo sapiens_hsa046141.55191809
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.54601359
20Selenocompound metabolism_Homo sapiens_hsa004501.51777474
21Tryptophan metabolism_Homo sapiens_hsa003801.48356617
22Autoimmune thyroid disease_Homo sapiens_hsa053201.47475967
23Malaria_Homo sapiens_hsa051441.40655491
24Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.38097818
25Amoebiasis_Homo sapiens_hsa051461.37030226
26* Phagosome_Homo sapiens_hsa041451.36525461
27Bladder cancer_Homo sapiens_hsa052191.35919812
28Histidine metabolism_Homo sapiens_hsa003401.34456755
29Complement and coagulation cascades_Homo sapiens_hsa046101.33240752
30Other glycan degradation_Homo sapiens_hsa005111.29503763
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.26830514
32Hippo signaling pathway_Homo sapiens_hsa043901.26705877
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.26565394
34Renal cell carcinoma_Homo sapiens_hsa052111.25980208
35Vibrio cholerae infection_Homo sapiens_hsa051101.22027874
36Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.21605568
37Rap1 signaling pathway_Homo sapiens_hsa040151.20736758
38Platelet activation_Homo sapiens_hsa046111.20606538
39Renin secretion_Homo sapiens_hsa049241.17986168
40Type I diabetes mellitus_Homo sapiens_hsa049401.14778463
41Regulation of actin cytoskeleton_Homo sapiens_hsa048101.14637411
42VEGF signaling pathway_Homo sapiens_hsa043701.12472258
43Small cell lung cancer_Homo sapiens_hsa052221.11947647
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09894222
45Rheumatoid arthritis_Homo sapiens_hsa053231.07517729
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06187819
47Proteoglycans in cancer_Homo sapiens_hsa052051.05983029
48Fatty acid elongation_Homo sapiens_hsa000621.05754471
49Axon guidance_Homo sapiens_hsa043601.02938198
50Endocytosis_Homo sapiens_hsa041441.02593777
51Taste transduction_Homo sapiens_hsa047421.02097752
52Fatty acid degradation_Homo sapiens_hsa000711.00472856
53Circadian rhythm_Homo sapiens_hsa047100.99438264
54Toxoplasmosis_Homo sapiens_hsa051450.96849329
55TGF-beta signaling pathway_Homo sapiens_hsa043500.95007650
56Dorso-ventral axis formation_Homo sapiens_hsa043200.92651088
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92490864
58Prion diseases_Homo sapiens_hsa050200.91886915
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89807239
60Gastric acid secretion_Homo sapiens_hsa049710.89382840
61Staphylococcus aureus infection_Homo sapiens_hsa051500.89192951
62Pancreatic cancer_Homo sapiens_hsa052120.85800207
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85305170
64Viral myocarditis_Homo sapiens_hsa054160.85154259
65Salmonella infection_Homo sapiens_hsa051320.84486711
66ABC transporters_Homo sapiens_hsa020100.84210889
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83459538
68Chemical carcinogenesis_Homo sapiens_hsa052040.82810023
69Arachidonic acid metabolism_Homo sapiens_hsa005900.80352983
70Bile secretion_Homo sapiens_hsa049760.79434736
71Hepatitis C_Homo sapiens_hsa051600.77221836
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.77013395
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.76436149
74Influenza A_Homo sapiens_hsa051640.75277408
75Thyroid cancer_Homo sapiens_hsa052160.75053622
76Collecting duct acid secretion_Homo sapiens_hsa049660.74415624
77Phenylalanine metabolism_Homo sapiens_hsa003600.73900679
78Linoleic acid metabolism_Homo sapiens_hsa005910.73509231
79Salivary secretion_Homo sapiens_hsa049700.73177728
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72567591
81Hematopoietic cell lineage_Homo sapiens_hsa046400.72565687
82Dilated cardiomyopathy_Homo sapiens_hsa054140.72463386
83GnRH signaling pathway_Homo sapiens_hsa049120.72132805
84Pathways in cancer_Homo sapiens_hsa052000.70826949
85beta-Alanine metabolism_Homo sapiens_hsa004100.70611079
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.68630732
87Choline metabolism in cancer_Homo sapiens_hsa052310.68173856
88Fatty acid metabolism_Homo sapiens_hsa012120.66588167
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.66261136
90Ether lipid metabolism_Homo sapiens_hsa005650.65786950
91Notch signaling pathway_Homo sapiens_hsa043300.65467887
92Endometrial cancer_Homo sapiens_hsa052130.64573772
93PPAR signaling pathway_Homo sapiens_hsa033200.63737479
94Glutathione metabolism_Homo sapiens_hsa004800.62202969
95PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61558126
96Thyroid hormone synthesis_Homo sapiens_hsa049180.58363590
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.57692737
98Apoptosis_Homo sapiens_hsa042100.57133319
99Sphingolipid metabolism_Homo sapiens_hsa006000.56030633
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55960263
101* Pertussis_Homo sapiens_hsa051330.55637930
102Shigellosis_Homo sapiens_hsa051310.54908161
103Tyrosine metabolism_Homo sapiens_hsa003500.53847643
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53735140
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53553790
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51837819
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51218418
108MAPK signaling pathway_Homo sapiens_hsa040100.50873897
109Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50053720
110Tuberculosis_Homo sapiens_hsa051520.49952794
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49696122
112Chronic myeloid leukemia_Homo sapiens_hsa052200.48355717
113Ras signaling pathway_Homo sapiens_hsa040140.48141922
114African trypanosomiasis_Homo sapiens_hsa051430.47476508
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47415356
116Acute myeloid leukemia_Homo sapiens_hsa052210.46945544
117TNF signaling pathway_Homo sapiens_hsa046680.46917587
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.45578779
119Insulin resistance_Homo sapiens_hsa049310.43081241
120Long-term depression_Homo sapiens_hsa047300.42788638
121Herpes simplex infection_Homo sapiens_hsa051680.42763127
122Gap junction_Homo sapiens_hsa045400.42105764
123Melanogenesis_Homo sapiens_hsa049160.41831759
124Protein digestion and absorption_Homo sapiens_hsa049740.41536482
125Leishmaniasis_Homo sapiens_hsa051400.41468007
126Primary bile acid biosynthesis_Homo sapiens_hsa001200.40568917
127Estrogen signaling pathway_Homo sapiens_hsa049150.40297804
128MicroRNAs in cancer_Homo sapiens_hsa052060.37714589
129Melanoma_Homo sapiens_hsa052180.37616769
130Antigen processing and presentation_Homo sapiens_hsa046120.37436184
131Retinol metabolism_Homo sapiens_hsa008300.36985502
132Chemokine signaling pathway_Homo sapiens_hsa040620.36963821
133Osteoclast differentiation_Homo sapiens_hsa043800.36562299
134Ovarian steroidogenesis_Homo sapiens_hsa049130.35892166

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