SFTPB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of complement activation (GO:0045916)7.35946820
2response to xenobiotic stimulus (GO:0009410)7.28449854
3pattern specification involved in kidney development (GO:0061004)6.86539076
4negative regulation of protein activation cascade (GO:2000258)6.56463859
5cellular response to nitric oxide (GO:0071732)6.28595154
6negative regulation of humoral immune response (GO:0002921)6.14595502
7positive regulation of endothelial cell differentiation (GO:0045603)6.01081677
8morphogenesis of an endothelium (GO:0003159)5.49538753
9endothelial tube morphogenesis (GO:0061154)5.49538753
10dichotomous subdivision of an epithelial terminal unit (GO:0060600)5.42863888
11regulation of endothelial cell differentiation (GO:0045601)5.39614032
12positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003605.23979126
13lung lobe morphogenesis (GO:0060463)5.15920072
14cellular response to reactive nitrogen species (GO:1902170)4.83176755
15neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)4.69603852
16response to nitric oxide (GO:0071731)4.66459711
17sodium-independent organic anion transport (GO:0043252)4.65872820
18regulation of phospholipid biosynthetic process (GO:0071071)4.59813167
19phosphate ion transmembrane transport (GO:0035435)4.59588560
20epithelial tube branching involved in lung morphogenesis (GO:0060441)4.48656548
21regulation of vasculogenesis (GO:2001212)4.27838411
22regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00434.22950390
23regulation of complement activation (GO:0030449)4.18254959
24trivalent inorganic anion homeostasis (GO:0072506)4.15223973
25phosphate ion homeostasis (GO:0055062)4.15223973
26endocrine hormone secretion (GO:0060986)4.10513560
27peptide catabolic process (GO:0043171)4.04202895
28mesodermal cell differentiation (GO:0048333)3.98520649
29respiratory tube development (GO:0030323)3.93421493
30cellular anion homeostasis (GO:0030002)3.91533086
31sodium ion homeostasis (GO:0055078)3.87013628
32regulation of protein activation cascade (GO:2000257)3.85122122
33lung vasculature development (GO:0060426)3.84938063
34blood vessel maturation (GO:0001955)3.83801758
35regulation of interleukin-13 production (GO:0032656)3.81394172
36phosphate ion transport (GO:0006817)3.79039170
37establishment of apical/basal cell polarity (GO:0035089)3.75977576
38negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.75417011
39endocardial cushion development (GO:0003197)3.72680460
40hyperosmotic salinity response (GO:0042538)3.70991966
41virion attachment to host cell (GO:0019062)3.65544102
42adhesion of symbiont to host cell (GO:0044650)3.65544102
43epithelial cell differentiation involved in prostate gland development (GO:0060742)3.57538275
44glomerular epithelial cell development (GO:0072310)3.56251683
45complement activation, classical pathway (GO:0006958)3.54915922
46protein localization to endosome (GO:0036010)3.54753590
47lung alveolus development (GO:0048286)3.53387535
48cellular hyperosmotic response (GO:0071474)3.53165599
49glomerular filtration (GO:0003094)3.51750504
50macrophage chemotaxis (GO:0048246)3.51235645
51hemidesmosome assembly (GO:0031581)3.47326328
52complement activation (GO:0006956)3.46935349
53cellular response to thyroid hormone stimulus (GO:0097067)3.42851058
54negative regulation of interleukin-2 production (GO:0032703)3.41113263
55iron ion import (GO:0097286)3.41085943
56lymphangiogenesis (GO:0001946)3.40341633
57renal absorption (GO:0070293)3.39929329
58induction of positive chemotaxis (GO:0050930)3.38344821
59cell adhesion mediated by integrin (GO:0033627)3.32470779
60* respiratory gaseous exchange (GO:0007585)3.26874121
61regulation of glomerular filtration (GO:0003093)3.26101846
62negative regulation of response to reactive oxygen species (GO:1901032)3.25131509
63establishment or maintenance of monopolar cell polarity (GO:0061339)3.21496010
64establishment of monopolar cell polarity (GO:0061162)3.21496010
65lung secretory cell differentiation (GO:0061140)3.16636377
66glomerular visceral epithelial cell development (GO:0072015)3.16393055
67Leydig cell differentiation (GO:0033327)3.15052500
68sphingosine metabolic process (GO:0006670)3.13272919
69embryonic foregut morphogenesis (GO:0048617)3.10228148
70branch elongation of an epithelium (GO:0060602)3.10182749
71regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.07631612
72adhesion of symbiont to host (GO:0044406)3.06669591
73positive regulation of vasculogenesis (GO:2001214)3.04976129
74response to vitamin A (GO:0033189)3.04667151
75negative regulation of alcohol biosynthetic process (GO:1902931)3.02057128
76hormone catabolic process (GO:0042447)2.96228025
77protein activation cascade (GO:0072376)2.95500527
78positive regulation of digestive system process (GO:0060456)2.95439035
79axis elongation (GO:0003401)2.95097544
80regulation of hippo signaling (GO:0035330)2.94844172
81extracellular matrix assembly (GO:0085029)2.94731716
82interleukin-6-mediated signaling pathway (GO:0070102)2.94140477
83negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.93787557
84cellular response to antibiotic (GO:0071236)2.92937451
85cellular sodium ion homeostasis (GO:0006883)2.91993882
86vascular endothelial growth factor signaling pathway (GO:0038084)2.91382282
87polyol transport (GO:0015791)2.90736877
88positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.89417509
89phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.87731806
90regulation of integrin-mediated signaling pathway (GO:2001044)2.87462422
91one-carbon compound transport (GO:0019755)2.86813186
92response to increased oxygen levels (GO:0036296)2.85559712
93response to hyperoxia (GO:0055093)2.85559712
94segment specification (GO:0007379)2.85085918
95long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.83808138
96icosanoid transport (GO:0071715)2.82377781
97fatty acid derivative transport (GO:1901571)2.82377781
98gas transport (GO:0015669)2.81260133
99negative regulation of fatty acid transport (GO:2000192)2.80923325
100membrane protein proteolysis (GO:0033619)2.79489396
101artery development (GO:0060840)2.78898688
102mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.78364368
103negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.78256243
104multicellular organismal water homeostasis (GO:0050891)2.74761598
105regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.74514145
106endothelial cell chemotaxis (GO:0035767)2.71715161
107diol metabolic process (GO:0034311)2.70012846
108norepinephrine metabolic process (GO:0042415)2.69481881
109regulation of interleukin-5 production (GO:0032674)2.69477864
110receptor catabolic process (GO:0032801)2.68195847
111negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.68016251
112branching involved in salivary gland morphogenesis (GO:0060445)2.67773540
113membrane raft organization (GO:0031579)2.67426561
114renal filtration (GO:0097205)2.65346345
115response to interleukin-6 (GO:0070741)2.65316595
116peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.64035350
117renal system process involved in regulation of blood volume (GO:0001977)2.63856948
118tight junction assembly (GO:0070830)2.63822409
119cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.62719143
120negative regulation of T cell proliferation (GO:0042130)2.62567655
121toxin metabolic process (GO:0009404)2.62285102
122protein autoprocessing (GO:0016540)2.60002899
123import into cell (GO:0098657)2.59808486
124endothelial cell differentiation (GO:0045446)2.59456781
125negative regulation of stress fiber assembly (GO:0051497)2.59381907
126negative regulation of epithelial to mesenchymal transition (GO:0010719)2.58783042
127polarized epithelial cell differentiation (GO:0030859)2.58546609
128blood vessel remodeling (GO:0001974)2.58411164
129positive regulation of p38MAPK cascade (GO:1900745)2.57669118
130complement activation, alternative pathway (GO:0006957)2.57347179
131establishment of endothelial barrier (GO:0061028)2.56476423
132atrioventricular valve morphogenesis (GO:0003181)2.55528390
133toxin transport (GO:1901998)2.54875289
134retina vasculature morphogenesis in camera-type eye (GO:0061299)2.54511785
135negative regulation of actin filament bundle assembly (GO:0032232)2.53523494
136glial cell proliferation (GO:0014009)2.53471801
137positive regulation of chemokine secretion (GO:0090197)2.52451340
138coronary vasculature morphogenesis (GO:0060977)2.51781729
139T cell mediated immunity (GO:0002456)2.50894866
140regulation of p38MAPK cascade (GO:1900744)2.50616875
141regulation of humoral immune response (GO:0002920)2.49362837
142hydrogen peroxide biosynthetic process (GO:0050665)2.49004802
143regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.48792761
144response to thyroid hormone (GO:0097066)2.48629544
145neuron remodeling (GO:0016322)2.48263237
146apoptotic cell clearance (GO:0043277)2.47403145
147ethanol oxidation (GO:0006069)2.46707953
148regulation of macrophage chemotaxis (GO:0010758)2.44243459
149keratan sulfate catabolic process (GO:0042340)2.42618529
150positive regulation of phosphatase activity (GO:0010922)2.42359144
151renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.41569444
152negative regulation of blood vessel endothelial cell migration (GO:0043537)2.36857865
153fibroblast migration (GO:0010761)2.36224177
154cell volume homeostasis (GO:0006884)2.35900416
155positive regulation of phagocytosis (GO:0050766)2.32145310
156surfactant homeostasis (GO:0043129)18.9504650
157chemical homeostasis within a tissue (GO:0048875)15.1883942

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human4.61998657
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.71556346
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.45393580
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.26330090
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.76554223
6CLOCK_20551151_ChIP-Seq_293T_Human2.76439509
7ESR1_20079471_ChIP-ChIP_T-47D_Human2.68722477
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.67933646
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.63818539
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.61990016
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.57510330
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.54377296
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.41901788
14GATA2_21666600_ChIP-Seq_HMVEC_Human2.41297633
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.32810174
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.29116608
17TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.27564021
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.26121454
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.10592010
20ESR1_21235772_ChIP-Seq_MCF-7_Human2.06144946
21CDX2_20551321_ChIP-Seq_CACO-2_Human1.96844878
22SOX2_20726797_ChIP-Seq_SW620_Human1.94593686
23AHR_22903824_ChIP-Seq_MCF-7_Human1.93918880
24FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.90358229
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.80249903
26* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.80147675
27TCF4_18268006_ChIP-ChIP_LS174T_Human1.78309451
28* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.64041993
29RACK7_27058665_Chip-Seq_MCF-7_Human1.64017502
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.62298288
31SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.62245250
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61951310
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60001033
34KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.59546209
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58878721
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.58832631
37SALL4_18804426_ChIP-ChIP_XEN_Mouse1.57736271
38RUNX1_27514584_Chip-Seq_MCF-7_Human1.54615775
39GATA4_25053715_ChIP-Seq_YYC3_Human1.54425903
40* LXR_22158963_ChIP-Seq_LIVER_Mouse1.54037354
41AR_21572438_ChIP-Seq_LNCaP_Human1.52374612
42BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.51477639
43CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.51057320
44* TBX20_22080862_ChIP-Seq_HEART_Mouse1.47165653
45* TBX20_22328084_ChIP-Seq_HEART_Mouse1.47165653
46KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46766602
47EP300_21415370_ChIP-Seq_HL-1_Mouse1.46632682
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.44511885
49SOX9_24532713_ChIP-Seq_HFSC_Mouse1.42457836
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.42014553
51ZNF263_19887448_ChIP-Seq_K562_Human1.41567871
52ARNT_22903824_ChIP-Seq_MCF-7_Human1.41481673
53NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.39651200
54TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39429276
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38391398
56NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.38036076
57CJUN_26792858_Chip-Seq_BT549_Human1.35202281
58ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34095744
59* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33517867
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31997140
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31902119
62ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.30390862
63IRF8_27001747_Chip-Seq_BMDM_Mouse1.30249542
64EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29604757
65ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.27615877
66CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.26272918
67NFIB_24661679_ChIP-Seq_LUNG_Mouse1.25169209
68SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.24148054
69SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.24092403
70SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.24092403
71HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23945271
72ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22475915
73Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22189827
74PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21285525
75SMAD3_21741376_ChIP-Seq_HESCs_Human1.20746144
76RXR_22158963_ChIP-Seq_LIVER_Mouse1.19782994
77FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.19129832
78* KDM2B_26808549_Chip-Seq_K562_Human1.18723461
79IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18207254
80SPI1_23127762_ChIP-Seq_K562_Human1.17926293
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17238152
82IRF8_22096565_ChIP-ChIP_GC-B_Human1.16384298
83TP53_18474530_ChIP-ChIP_U2OS_Human1.14824201
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.13692302
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11513390
86* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11475635
87KLF5_25053715_ChIP-Seq_YYC3_Human1.11333866
88PPARA_22158963_ChIP-Seq_LIVER_Mouse1.10924637
89ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10890477
90CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10081846
91FOXA2_19822575_ChIP-Seq_HepG2_Human1.10044781
92CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09340226
93GATA1_19941826_ChIP-Seq_K562_Human1.09238446
94NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08037804
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08037804
96SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07426955
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07335224
98VDR_24787735_ChIP-Seq_THP-1_Human1.06808074
99E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06183521
100P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05602704
101PIAS1_25552417_ChIP-Seq_VCAP_Human1.05229839
102LXR_22292898_ChIP-Seq_THP-1_Human1.05064705
103ISL1_27105846_Chip-Seq_CPCs_Mouse1.04712605
104TP63_17297297_ChIP-ChIP_HaCaT_Human1.04592183
105P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03419018
106GATA6_25053715_ChIP-Seq_YYC3_Human1.03211495
107MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02894545
108AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.02611567
109SMAD4_21741376_ChIP-Seq_HESCs_Human1.01004369
110FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99658432
111FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99124990
112STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99009362
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98048861
114RUNX_20019798_ChIP-Seq_JUKART_Human0.97347957
115PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97002271
116SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94962953
117WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94368496
118SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.93530189
119CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93184902
120GATA3_24758297_ChIP-Seq_MCF-7_Human0.92897377
121IRF8_21731497_ChIP-ChIP_J774_Mouse0.92800224
122STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92659798
123TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92576413
124WT1_19549856_ChIP-ChIP_CCG9911_Human0.92548211
125ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92337801
126TP63_23658742_ChIP-Seq_EP156T_Human0.91344314
127RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91170223
128SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91042202
129SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.90303181
130* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89490871
131SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.89087518
132NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88072914
133NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87051739
134ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85999774
135STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.84350180

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004782_abnormal_surfactant_physiolog9.97782200
2MP0001958_emphysema6.03306707
3MP0008995_early_reproductive_senescence4.94882319
4MP0008004_abnormal_stomach_pH4.26554373
5MP0005083_abnormal_biliary_tract4.12417782
6MP0010368_abnormal_lymphatic_system3.68090392
7MP0002138_abnormal_hepatobiliary_system3.10833147
8MP0003724_increased_susceptibility_to2.90506080
9MP0001542_abnormal_bone_strength2.88759691
10MP0002295_abnormal_pulmonary_circulatio2.64226539
11MP0005167_abnormal_blood-brain_barrier2.50008034
12MP0001879_abnormal_lymphatic_vessel2.43640168
13* MP0002133_abnormal_respiratory_system2.40991502
14* MP0005388_respiratory_system_phenotype2.40991502
15MP0003191_abnormal_cellular_cholesterol2.37518565
16MP0000537_abnormal_urethra_morphology2.05624201
17MP0010234_abnormal_vibrissa_follicle2.01827984
18MP0002132_abnormal_respiratory_system2.01002399
19* MP0001177_atelectasis1.95589297
20MP0008875_abnormal_xenobiotic_pharmacok1.75729911
21MP0004272_abnormal_basement_membrane1.74959312
22MP0000566_synostosis1.73911948
23MP0010352_gastrointestinal_tract_polyps1.51950883
24MP0002277_abnormal_respiratory_mucosa1.50760456
25MP0005058_abnormal_lysosome_morphology1.50007263
26MP0005503_abnormal_tendon_morphology1.44876323
27MP0003950_abnormal_plasma_membrane1.41023584
28MP0003566_abnormal_cell_adhesion1.34357397
29MP0003115_abnormal_respiratory_system1.32558218
30MP0003690_abnormal_glial_cell1.32040592
31MP0009780_abnormal_chondrocyte_physiolo1.30257569
32MP0001440_abnormal_grooming_behavior1.29789683
33* MP0001175_abnormal_lung_morphology1.29508675
34MP0002998_abnormal_bone_remodeling1.26566821
35MP0000534_abnormal_ureter_morphology1.25232769
36MP0005275_abnormal_skin_tensile1.25072436
37MP0004883_abnormal_blood_vessel1.17190616
38MP0003786_premature_aging1.13932254
39MP0005165_increased_susceptibility_to1.12069396
40MP0005164_abnormal_response_to1.10933346
41MP0000343_altered_response_to1.07492350
42MP0000767_abnormal_smooth_muscle1.06227944
43MP0000249_abnormal_blood_vessel1.03429242
44MP0009840_abnormal_foam_cell1.01404800
45MP0002139_abnormal_hepatobiliary_system1.00069304
46MP0001851_eye_inflammation0.99451902
47MP0005023_abnormal_wound_healing0.98212317
48MP0002098_abnormal_vibrissa_morphology0.96157417
49MP0006054_spinal_hemorrhage0.95254028
50MP0003303_peritoneal_inflammation0.92700172
51MP0005085_abnormal_gallbladder_physiolo0.91978673
52MP0005166_decreased_susceptibility_to0.91806399
53MP0010678_abnormal_skin_adnexa0.90281872
54MP0002234_abnormal_pharynx_morphology0.89118069
55MP0001545_abnormal_hematopoietic_system0.88661866
56MP0005397_hematopoietic_system_phenotyp0.88661866
57MP0003091_abnormal_cell_migration0.88475912
58MP0006138_congestive_heart_failure0.88128807
59MP0005595_abnormal_vascular_smooth0.88106389
60MP0002796_impaired_skin_barrier0.87755369
61MP0004185_abnormal_adipocyte_glucose0.86255731
62MP0002909_abnormal_adrenal_gland0.82564050
63MP0000013_abnormal_adipose_tissue0.82464176
64MP0004484_altered_response_of0.82428338
65MP0005408_hypopigmentation0.81527333
66MP0001664_abnormal_digestion0.81207953
67MP0001756_abnormal_urination0.79366843
68MP0000465_gastrointestinal_hemorrhage0.78231481
69MP0002332_abnormal_exercise_endurance0.77941407
70MP0004947_skin_inflammation0.77536549
71MP0002877_abnormal_melanocyte_morpholog0.75977384
72MP0003705_abnormal_hypodermis_morpholog0.75742013
73MP0000462_abnormal_digestive_system0.75631678
74MP0003075_altered_response_to0.74954103
75MP0002405_respiratory_system_inflammati0.74763295
76MP0003279_aneurysm0.74543786
77* MP0001943_abnormal_respiration0.74137075
78MP0000516_abnormal_urinary_system0.73207012
79MP0005367_renal/urinary_system_phenotyp0.73207012
80MP0005025_abnormal_response_to0.73047135
81MP0002419_abnormal_innate_immunity0.72828442
82MP0001666_abnormal_nutrient_absorption0.71195135
83MP0010329_abnormal_lipoprotein_level0.70547587
84MP0001533_abnormal_skeleton_physiology0.70057731
85MP0008438_abnormal_cutaneous_collagen0.69996130
86MP0002166_altered_tumor_susceptibility0.69148467
87* MP0002118_abnormal_lipid_homeostasis0.68526592
88MP0002128_abnormal_blood_circulation0.68031035
89MP0001501_abnormal_sleep_pattern0.67573658
90MP0006082_CNS_inflammation0.67055551
91MP0002925_abnormal_cardiovascular_devel0.66989496
92MP0003119_abnormal_digestive_system0.66474459
93MP0003448_altered_tumor_morphology0.65878595
94MP0003890_abnormal_embryonic-extraembry0.64993996
95MP0000681_abnormal_thyroid_gland0.63147150
96MP0004085_abnormal_heartbeat0.63055804
97MP0002168_other_aberrant_phenotype0.62924382
98MP0003656_abnormal_erythrocyte_physiolo0.62796736
99MP0003453_abnormal_keratinocyte_physiol0.62039944
100MP0000627_abnormal_mammary_gland0.60640460
101MP0001986_abnormal_taste_sensitivity0.60261736
102MP0001614_abnormal_blood_vessel0.59624136
103MP0001661_extended_life_span0.59386490
104MP0002933_joint_inflammation0.59249037
105MP0001849_ear_inflammation0.58718662
106MP0001853_heart_inflammation0.58683155
107MP0004084_abnormal_cardiac_muscle0.58405922
108MP0009643_abnormal_urine_homeostasis0.58095027
109MP0008961_abnormal_basal_metabolism0.57737564
110MP0002136_abnormal_kidney_physiology0.57319083
111MP0004858_abnormal_nervous_system0.56990526
112MP0003329_amyloid_beta_deposits0.56399999
113MP0003300_gastrointestinal_ulcer0.56157073
114MP0003638_abnormal_response/metabolism_0.55721569
115MP0003436_decreased_susceptibility_to0.55623698
116MP0004130_abnormal_muscle_cell0.54810681
117MP0000383_abnormal_hair_follicle0.54428150
118MP0008775_abnormal_heart_ventricle0.53121852
119MP0000685_abnormal_immune_system0.52952053
120MP0003045_fibrosis0.52749899
121MP0009764_decreased_sensitivity_to0.51871831
122MP0000639_abnormal_adrenal_gland0.51245222
123MP0005647_abnormal_sex_gland0.50105802
124MP0005257_abnormal_intraocular_pressure0.49901805
125MP0002135_abnormal_kidney_morphology0.49406017
126MP0009384_cardiac_valve_regurgitation0.49174769
127MP0003828_pulmonary_edema0.48774352
128MP0001790_abnormal_immune_system0.48468909
129MP0005387_immune_system_phenotype0.48468909
130MP0002733_abnormal_thermal_nociception0.46933111
131MP0005390_skeleton_phenotype0.45013773
132MP0003795_abnormal_bone_structure0.44980937
133MP0009785_altered_susceptibility_to0.43040575

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)7.79413579
2Tubulointerstitial fibrosis (HP:0005576)6.82793807
3Chronic bronchitis (HP:0004469)6.50676855
4Renal salt wasting (HP:0000127)6.24654313
5Abnormality of the fingertips (HP:0001211)5.90266041
6Systemic lupus erythematosus (HP:0002725)5.40943706
7Gout (HP:0001997)5.33729441
8Polycythemia (HP:0001901)5.27876882
9Complement deficiency (HP:0004431)5.13170638
10Glomerulonephritis (HP:0000099)5.01907646
11Neurofibrillary tangles (HP:0002185)4.84701345
12Hyperkalemia (HP:0002153)4.75189760
13Alveolar cell carcinoma (HP:0006519)4.73955008
14Onycholysis (HP:0001806)4.48229666
15Abnormality of complement system (HP:0005339)4.40695462
16Neoplasm of the tracheobronchial system (HP:0100552)4.38777489
17* Respiratory distress (HP:0002098)4.29335943
18Hematochezia (HP:0002573)4.24820604
19* Tachypnea (HP:0002789)4.00162448
20Cerebral inclusion bodies (HP:0100314)3.92217131
21Tubulointerstitial abnormality (HP:0001969)3.86286564
22Abnormality of the nasal mucosa (HP:0000433)3.79965321
23Thyroid-stimulating hormone excess (HP:0002925)3.75451978
24Hyperaldosteronism (HP:0000859)3.73125955
25Ulnar bowing (HP:0003031)3.70195721
26Nephritis (HP:0000123)3.60582013
27Tubulointerstitial nephritis (HP:0001970)3.57089353
28Spontaneous hematomas (HP:0007420)3.52555130
29Exertional dyspnea (HP:0002875)3.51924732
30Visceral angiomatosis (HP:0100761)3.51163742
31Abnormality of chloride homeostasis (HP:0011422)3.45469686
32Hypotension (HP:0002615)3.34176818
33Hemangiomatosis (HP:0007461)3.29701617
34Long toe (HP:0010511)3.25167777
35Abnormality of renin-angiotensin system (HP:0000847)3.22884210
36Aortic aneurysm (HP:0004942)3.20941601
37Neonatal respiratory distress (HP:0002643)3.16554550
38Broad metatarsal (HP:0001783)3.15683106
39Bronchitis (HP:0012387)3.11578352
40Supranuclear gaze palsy (HP:0000605)3.09617919
41Pulmonary fibrosis (HP:0002206)3.04300973
42Esophageal varix (HP:0002040)3.03430595
43Eczematoid dermatitis (HP:0000976)2.93306749
44* Pulmonary hypertension (HP:0002092)2.91358148
45Tubular atrophy (HP:0000092)2.91255256
46Loss of speech (HP:0002371)2.89766213
47Hypergammaglobulinemia (HP:0010702)2.88625676
48Segmental peripheral demyelination/remyelination (HP:0003481)2.77943966
49Chronic otitis media (HP:0000389)2.77454671
50Hyponatremia (HP:0002902)2.66731792
51Bowing of the arm (HP:0006488)2.66645102
52Bowed forearm bones (HP:0003956)2.66645102
53Fragile nails (HP:0001808)2.65516410
54Decreased circulating renin level (HP:0003351)2.65133649
55Recurrent gram-negative bacterial infections (HP:0005420)2.63781066
56Cerebral aneurysm (HP:0004944)2.62169899
57Neoplasm of the lung (HP:0100526)2.61064320
58Growth hormone excess (HP:0000845)2.60439260
59Abnormality of the fetal cardiovascular system (HP:0010948)2.59650064
60Abnormal umbilical cord blood vessels (HP:0011403)2.59650064
61Single umbilical artery (HP:0001195)2.59650064
62Striae distensae (HP:0001065)2.48796240
63Bronchomalacia (HP:0002780)2.47947905
64Glomerulosclerosis (HP:0000096)2.46795750
65Osteolytic defects of the hand bones (HP:0009699)2.38042742
66Osteolytic defects of the phalanges of the hand (HP:0009771)2.38042742
67Atrophic scars (HP:0001075)2.37795259
68Milia (HP:0001056)2.33901425
69Conjunctival telangiectasia (HP:0000524)2.32950311
70Restrictive lung disease (HP:0002091)2.30956918
71Increased purine levels (HP:0004368)2.27820947
72Hyperuricemia (HP:0002149)2.27820947
73Neoplasm of the respiratory system (HP:0100606)2.24366318
74Potter facies (HP:0002009)2.23008787
75Facial shape deformation (HP:0011334)2.23008787
76Cerebral hemorrhage (HP:0001342)2.21988243
77Adrenal overactivity (HP:0002717)2.20258312
78Aortic dissection (HP:0002647)2.17845714
79Stomach cancer (HP:0012126)2.15977307
80Ulnar claw (HP:0001178)2.15973283
81Glucose intolerance (HP:0000833)2.14248719
82Subacute progressive viral hepatitis (HP:0006572)2.13277081
83Megalencephaly (HP:0001355)2.12456365
84Abnormality of sodium homeostasis (HP:0010931)2.11728056
85Abnormality of the vasculature of the conjunctiva (HP:0008054)2.11260372
86Deep venous thrombosis (HP:0002625)2.08120410
87Abnormality of macrophages (HP:0004311)2.03947429
88Increased CSF protein (HP:0002922)2.02582942
89Shallow orbits (HP:0000586)2.01642703
90Stenosis of the external auditory canal (HP:0000402)2.00424527
91* Interstitial pulmonary disease (HP:0006530)10.1912716
92Hypokalemic alkalosis (HP:0001949)1.99456822
93Pulmonary artery stenosis (HP:0004415)1.90507309
94Mitral valve prolapse (HP:0001634)1.89363506
95Abnormality of the gastric mucosa (HP:0004295)1.88525540
96Skin nodule (HP:0200036)1.86957819
97Mildly elevated creatine phosphokinase (HP:0008180)1.86935509
98Humeroradial synostosis (HP:0003041)1.86918131
99Synostosis involving the elbow (HP:0003938)1.86918131
100Microcytic anemia (HP:0001935)1.86316403
101Joint swelling (HP:0001386)1.85950199
102Hyperpituitarism (HP:0010514)1.84054399
103Flexion contracture of toe (HP:0005830)1.82928274
104Joint contractures involving the joints of the feet (HP:0100492)1.82928274
105Abnormality of purine metabolism (HP:0004352)1.82309224
106Prostate neoplasm (HP:0100787)1.82263738
107Bronchiectasis (HP:0002110)1.81435950
108Turricephaly (HP:0000262)1.79713905
109Aneurysm (HP:0002617)1.79585516
110Aplasia involving bones of the extremities (HP:0009825)1.77153231
111Aplasia involving bones of the upper limbs (HP:0009823)1.77153231
112Aplasia of the phalanges of the hand (HP:0009802)1.77153231
113Cavernous hemangioma (HP:0001048)1.74388768
114Rectal prolapse (HP:0002035)1.71912683
115Wormian bones (HP:0002645)1.71325219
116Prolonged neonatal jaundice (HP:0006579)1.70837239
117Progressive sensorineural hearing impairment (HP:0000408)1.70796007
118Right ventricular cardiomyopathy (HP:0011663)1.70256382
119Shawl scrotum (HP:0000049)1.70170583
120Annular pancreas (HP:0001734)1.68253735
121Camptodactyly of toe (HP:0001836)1.67405758
122Thickened helices (HP:0000391)1.66668847
123Dilatation of the ascending aorta (HP:0005111)1.66150404
124Buphthalmos (HP:0000557)1.65832027
125Adactyly (HP:0009776)1.64272096
126Distal lower limb muscle weakness (HP:0009053)1.64008404
127Plantar hyperkeratosis (HP:0007556)1.63942546
128Vascular tortuosity (HP:0004948)1.63928947
129Mitral stenosis (HP:0001718)1.63568333
130Urinary glycosaminoglycan excretion (HP:0003541)1.62842816
131Mucopolysacchariduria (HP:0008155)1.62842816
132Recurrent abscess formation (HP:0002722)1.62595458
133Dehydration (HP:0001944)1.62560876
134Aortic valve stenosis (HP:0001650)1.62228231
135Arterial tortuosity (HP:0005116)1.61786472
136Seborrheic dermatitis (HP:0001051)1.58974666
137Increased connective tissue (HP:0009025)1.58803314
138Split foot (HP:0001839)1.58613920
139Pustule (HP:0200039)1.58525627
140Abnormal hemoglobin (HP:0011902)1.57897126
141Cerebral palsy (HP:0100021)1.57170374
142Abnormality of the renal collecting system (HP:0004742)1.56339247
143Absent hand (HP:0004050)1.54975670
144Abnormal glucose tolerance (HP:0001952)1.52806162
145Portal hypertension (HP:0001409)1.50947959
146Joint hemorrhage (HP:0005261)1.49029276
147Persistence of primary teeth (HP:0006335)1.48980553
148Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.47806705
149Abnormality of polysaccharide metabolism (HP:0011012)1.47563847
150Abnormality of glycosaminoglycan metabolism (HP:0004371)1.47563847
151Abnormality of mucopolysaccharide metabolism (HP:0011020)1.47563847
152Abnormality of calcium-phosphate metabolism (HP:0100530)1.47144409
153Overgrowth (HP:0001548)1.46564306
154Abnormality of the periventricular white matter (HP:0002518)1.46338040
155Gingivitis (HP:0000230)1.46042362

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.04811236
2STK244.42444197
3FGFR24.31682857
4LRRK23.54259084
5TGFBR23.50543390
6ZAP702.81326264
7TRIB32.66778186
8EPHB12.61907495
9PAK42.38630068
10RIPK12.36287078
11DAPK22.26264080
12EPHB22.22145945
13EPHA22.13257143
14MST42.08861433
15NLK2.05603612
16ILK2.00029358
17PDGFRB1.98307352
18ERN11.93600985
19CDC42BPA1.92377653
20FER1.81780973
21MAP3K21.77983475
22STK101.74191366
23FGFR41.73793665
24STK38L1.68518490
25MAPK151.54010637
26IRAK11.50056212
27PTK61.49075406
28LATS21.45951921
29MAP3K61.41745621
30PRPF4B1.40892023
31MST1R1.38629408
32GRK11.38447778
33TYK21.38000958
34MAP3K91.36683215
35KSR21.34255176
36MAP3K141.33016384
37LMTK21.32215023
38PDGFRA1.31647384
39MYLK1.28158066
40MAP3K131.25181208
41TAOK31.21197418
42CAMK1D1.19941401
43CDK61.19641864
44EPHA31.16502756
45MET1.15793723
46AKT31.14954815
47YES11.14525348
48TRPM71.12738647
49TESK11.09748392
50FGFR31.09083385
51LATS11.07061903
52GSK3A1.05980057
53KIT1.05011554
54MAP3K31.04078516
55MAPK71.01468521
56TGFBR10.94596968
57EGFR0.92978415
58SIK10.91665993
59PTK20.91562843
60CSK0.88589502
61PRKD10.88137775
62SGK20.83907555
63CAMK1G0.82999359
64BLK0.80887898
65KDR0.80618618
66BCR0.80051109
67MAPK120.79689801
68NTRK10.78722128
69MAP2K30.75637855
70MAP2K20.73509666
71MAP3K10.72593335
72MAP3K120.72186158
73PKN20.67080386
74LIMK10.66818676
75ERBB20.65832440
76DDR20.63827383
77PDK20.63686964
78NEK90.62098499
79MARK20.61885811
80SGK2230.61601646
81SGK4940.61601646
82DAPK30.61122241
83DMPK0.60694181
84PDPK10.60357527
85STK380.60120983
86ERBB40.59995940
87FGFR10.57188458
88PTK2B0.57013163
89MAP2K10.55511732
90PRKCQ0.53921087
91DAPK10.53299114
92RPS6KA40.52700342
93INSR0.51473011
94MELK0.50899390
95NEK60.50806980
96RET0.48892620
97TYRO30.47744532
98MAPKAPK20.47535235
99STK390.47245043
100MAP3K70.47009334
101MATK0.46909753
102ROCK20.46216772
103RPS6KC10.46162153
104RPS6KL10.46162153
105GRK50.46131049
106NME10.46128980
107ERBB30.43010929
108PRKCH0.41674307
109BMX0.39771127
110TTN0.39401414
111PRKG20.38898739
112MAPK30.38379061
113MTOR0.37263061
114STK30.37059656
115GRK70.36214183
116ABL10.35931592
117RPS6KA60.35874335
118HIPK20.35709797
119DYRK1B0.35346501
120PRKCE0.34634420
121JAK10.33078433
122MAPK40.31961099
123FYN0.31848090
124MAPK10.31034886
125WNK40.30513721
126RPS6KA50.30496601
127RPS6KA20.29070207
128FGR0.28512236
129CHUK0.27045388
130FES0.26956709
131ROCK10.26855814
132TEC0.26596053
133IGF1R0.26377047
134SGK30.25314243
135MAP2K60.25235264
136SRC0.24522674
137ICK0.23570799
138JAK20.23193410
139TBK10.22471605
140PRKD20.22272420
141MAP3K80.21859357

Predicted pathways (KEGG)

RankGene SetZ-score
1Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049603.47831441
2Mineral absorption_Homo sapiens_hsa049783.25874938
3ECM-receptor interaction_Homo sapiens_hsa045122.51370243
4Fatty acid biosynthesis_Homo sapiens_hsa000612.35014126
5Adherens junction_Homo sapiens_hsa045202.31503699
6Lysosome_Homo sapiens_hsa041422.19072176
7Caffeine metabolism_Homo sapiens_hsa002322.09171828
8Leukocyte transendothelial migration_Homo sapiens_hsa046702.04343372
9Asthma_Homo sapiens_hsa053102.03960678
10Tight junction_Homo sapiens_hsa045301.92446771
11Graft-versus-host disease_Homo sapiens_hsa053321.80849575
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.77516061
13Bladder cancer_Homo sapiens_hsa052191.75365619
14AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.75342643
15Phagosome_Homo sapiens_hsa041451.73051647
16Allograft rejection_Homo sapiens_hsa053301.71888919
17Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.68050361
18Autoimmune thyroid disease_Homo sapiens_hsa053201.66839866
19Focal adhesion_Homo sapiens_hsa045101.65617082
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.48890309
21Renin-angiotensin system_Homo sapiens_hsa046141.44282594
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.43584522
23Hippo signaling pathway_Homo sapiens_hsa043901.41512105
24Pertussis_Homo sapiens_hsa051331.41363883
25Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.38026405
26Leishmaniasis_Homo sapiens_hsa051401.30844560
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.30258961
28Type I diabetes mellitus_Homo sapiens_hsa049401.27519548
29Renal cell carcinoma_Homo sapiens_hsa052111.26677653
30Small cell lung cancer_Homo sapiens_hsa052221.26150634
31Amoebiasis_Homo sapiens_hsa051461.25512803
32Fatty acid elongation_Homo sapiens_hsa000621.24504074
33Malaria_Homo sapiens_hsa051441.19340796
34VEGF signaling pathway_Homo sapiens_hsa043701.18478208
35Antigen processing and presentation_Homo sapiens_hsa046121.15154427
36Thyroid cancer_Homo sapiens_hsa052161.15091937
37Rap1 signaling pathway_Homo sapiens_hsa040151.13058066
38Circadian rhythm_Homo sapiens_hsa047101.12157085
39Vibrio cholerae infection_Homo sapiens_hsa051101.11677045
40Platelet activation_Homo sapiens_hsa046111.10219973
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09713610
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09528962
43Regulation of actin cytoskeleton_Homo sapiens_hsa048101.07143543
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07094690
45Histidine metabolism_Homo sapiens_hsa003401.06805325
46Proteoglycans in cancer_Homo sapiens_hsa052051.05758690
47Fatty acid degradation_Homo sapiens_hsa000711.04310951
48Tryptophan metabolism_Homo sapiens_hsa003801.04115690
49Gastric acid secretion_Homo sapiens_hsa049711.03104739
50Endocytosis_Homo sapiens_hsa041441.01551287
51Toxoplasmosis_Homo sapiens_hsa051451.00131408
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00078135
53Dorso-ventral axis formation_Homo sapiens_hsa043200.99819241
54Taste transduction_Homo sapiens_hsa047420.98944761
55Renin secretion_Homo sapiens_hsa049240.97323241
56Ether lipid metabolism_Homo sapiens_hsa005650.96752732
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96323643
58Endometrial cancer_Homo sapiens_hsa052130.95945340
59Axon guidance_Homo sapiens_hsa043600.95195899
60Other glycan degradation_Homo sapiens_hsa005110.94041519
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93611456
62ABC transporters_Homo sapiens_hsa020100.92472825
63TGF-beta signaling pathway_Homo sapiens_hsa043500.90222151
64Pancreatic cancer_Homo sapiens_hsa052120.88822436
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88711163
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88650436
67Hematopoietic cell lineage_Homo sapiens_hsa046400.85707725
68Osteoclast differentiation_Homo sapiens_hsa043800.84067293
69Salmonella infection_Homo sapiens_hsa051320.82885783
70Salivary secretion_Homo sapiens_hsa049700.80976763
71Complement and coagulation cascades_Homo sapiens_hsa046100.80410998
72Fatty acid metabolism_Homo sapiens_hsa012120.77870691
73Viral myocarditis_Homo sapiens_hsa054160.77703412
74Glutathione metabolism_Homo sapiens_hsa004800.76840857
75Influenza A_Homo sapiens_hsa051640.75661159
76Bile secretion_Homo sapiens_hsa049760.75023336
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.74333374
78Dilated cardiomyopathy_Homo sapiens_hsa054140.74249958
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74024425
80Pathways in cancer_Homo sapiens_hsa052000.73477371
81Prion diseases_Homo sapiens_hsa050200.73430387
82Rheumatoid arthritis_Homo sapiens_hsa053230.71653570
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.71420471
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71170484
85Hepatitis C_Homo sapiens_hsa051600.71078259
86Arachidonic acid metabolism_Homo sapiens_hsa005900.69962097
87Chronic myeloid leukemia_Homo sapiens_hsa052200.69060053
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.68979091
89Collecting duct acid secretion_Homo sapiens_hsa049660.67154569
90Protein digestion and absorption_Homo sapiens_hsa049740.67134183
91Linoleic acid metabolism_Homo sapiens_hsa005910.66390677
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66094310
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.65975292
94Selenocompound metabolism_Homo sapiens_hsa004500.64507132
95Phenylalanine metabolism_Homo sapiens_hsa003600.63395964
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.63271865
97Acute myeloid leukemia_Homo sapiens_hsa052210.62905981
98Thyroid hormone synthesis_Homo sapiens_hsa049180.60192072
99Sphingolipid metabolism_Homo sapiens_hsa006000.59826932
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59430787
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.58147465
102Shigellosis_Homo sapiens_hsa051310.57876299
103Chemical carcinogenesis_Homo sapiens_hsa052040.56629511
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56029134
105GnRH signaling pathway_Homo sapiens_hsa049120.55635754
106PPAR signaling pathway_Homo sapiens_hsa033200.54998155
107beta-Alanine metabolism_Homo sapiens_hsa004100.54721634
108Choline metabolism in cancer_Homo sapiens_hsa052310.53645093
109African trypanosomiasis_Homo sapiens_hsa051430.50553333
110Estrogen signaling pathway_Homo sapiens_hsa049150.50138989
111Colorectal cancer_Homo sapiens_hsa052100.49889337
112Melanoma_Homo sapiens_hsa052180.48340968
113MAPK signaling pathway_Homo sapiens_hsa040100.47492425
114Nitrogen metabolism_Homo sapiens_hsa009100.47330758
115Tyrosine metabolism_Homo sapiens_hsa003500.46875191
116MicroRNAs in cancer_Homo sapiens_hsa052060.46712019
117Apoptosis_Homo sapiens_hsa042100.45991130
118Insulin resistance_Homo sapiens_hsa049310.45489654
119Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45105694
120Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45020347
121Ras signaling pathway_Homo sapiens_hsa040140.44978048
122TNF signaling pathway_Homo sapiens_hsa046680.44642298
123Herpes simplex infection_Homo sapiens_hsa051680.44372185
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.43162983
125Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42983119
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42507373
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42243480
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42048023
129Prostate cancer_Homo sapiens_hsa052150.41908057
130Prolactin signaling pathway_Homo sapiens_hsa049170.40309498
131Serotonergic synapse_Homo sapiens_hsa047260.40068164
132Notch signaling pathway_Homo sapiens_hsa043300.39907735
133Gap junction_Homo sapiens_hsa045400.39782995
134Chemokine signaling pathway_Homo sapiens_hsa040620.39695210
135Staphylococcus aureus infection_Homo sapiens_hsa051500.38883025
136Ovarian steroidogenesis_Homo sapiens_hsa049130.38882546
137Tuberculosis_Homo sapiens_hsa051520.38137287
138Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37974367

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