SFTPC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of complement activation (GO:0045916)7.68436071
2positive regulation of endothelial cell differentiation (GO:0045603)7.09029435
3peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)6.92637866
4negative regulation of protein activation cascade (GO:2000258)6.84635476
5negative regulation of humoral immune response (GO:0002921)6.47853150
6lung lobe morphogenesis (GO:0060463)6.43989623
7regulation of endothelial cell differentiation (GO:0045601)6.42461651
8endothelial tube morphogenesis (GO:0061154)6.10005076
9morphogenesis of an endothelium (GO:0003159)6.10005076
10response to xenobiotic stimulus (GO:0009410)5.86331546
11dichotomous subdivision of an epithelial terminal unit (GO:0060600)5.81560344
12pattern specification involved in kidney development (GO:0061004)5.42451970
13regulation of vasculogenesis (GO:2001212)5.09497393
14positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003604.85704744
15respiratory tube development (GO:0030323)4.82333524
16peptide catabolic process (GO:0043171)4.78743489
17blood vessel maturation (GO:0001955)4.73286058
18lung vasculature development (GO:0060426)4.63461162
19epithelial tube branching involved in lung morphogenesis (GO:0060441)4.54233270
20phosphate ion transmembrane transport (GO:0035435)4.46606303
21mesodermal cell differentiation (GO:0048333)4.38127306
22lymphangiogenesis (GO:0001946)4.21989674
23regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00434.21655911
24establishment of apical/basal cell polarity (GO:0035089)4.21039502
25sodium-independent organic anion transport (GO:0043252)4.20275313
26regulation of complement activation (GO:0030449)4.14982784
27endocardial cushion development (GO:0003197)4.05147644
28trivalent inorganic anion homeostasis (GO:0072506)4.04036016
29phosphate ion homeostasis (GO:0055062)4.04036016
30adhesion of symbiont to host cell (GO:0044650)4.00863986
31virion attachment to host cell (GO:0019062)4.00863986
32cellular response to thyroid hormone stimulus (GO:0097067)3.95812811
33cellular hyperosmotic response (GO:0071474)3.91245490
34regulation of phospholipid biosynthetic process (GO:0071071)3.91219362
35artery development (GO:0060840)3.90119415
36epithelial cell differentiation involved in prostate gland development (GO:0060742)3.86578820
37regulation of protein activation cascade (GO:2000257)3.82128219
38hemidesmosome assembly (GO:0031581)3.77751441
39positive regulation of vasculogenesis (GO:2001214)3.75796215
40hyperosmotic salinity response (GO:0042538)3.75231717
41cellular anion homeostasis (GO:0030002)3.72401726
42lung alveolus development (GO:0048286)3.70655489
43sodium ion homeostasis (GO:0055078)3.70388263
44embryonic foregut morphogenesis (GO:0048617)3.64096656
45phosphate ion transport (GO:0006817)3.60420999
46negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.59046200
47establishment or maintenance of monopolar cell polarity (GO:0061339)3.56637109
48establishment of monopolar cell polarity (GO:0061162)3.56637109
49cellular response to antibiotic (GO:0071236)3.54825861
50negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.54771587
51renal absorption (GO:0070293)3.50013739
52regulation of glomerular filtration (GO:0003093)3.47680693
53glomerular epithelial cell development (GO:0072310)3.47427508
54positive regulation of digestive system process (GO:0060456)3.46282290
55cell adhesion mediated by integrin (GO:0033627)3.44055550
56* respiratory gaseous exchange (GO:0007585)3.42613630
57regulation of integrin-mediated signaling pathway (GO:2001044)3.39488997
58lung secretory cell differentiation (GO:0061140)3.36027839
59complement activation (GO:0006956)3.34976964
60protein localization to endosome (GO:0036010)3.33027525
61glomerular filtration (GO:0003094)3.32547232
62adhesion of symbiont to host (GO:0044406)3.32367485
63iron ion import (GO:0097286)3.31963418
64endocrine hormone secretion (GO:0060986)3.31628481
65regulation of cardioblast differentiation (GO:0051890)3.31423334
66wound healing, spreading of epidermal cells (GO:0035313)3.30518960
67vascular endothelial growth factor signaling pathway (GO:0038084)3.29998888
68membrane protein proteolysis (GO:0033619)3.26823479
69polyol transport (GO:0015791)3.26420071
70complement activation, classical pathway (GO:0006958)3.24877026
71ethanol oxidation (GO:0006069)3.23026896
72macrophage chemotaxis (GO:0048246)3.22961123
73regulation of interleukin-2 biosynthetic process (GO:0045076)3.22928750
74extracellular matrix assembly (GO:0085029)3.18635820
75icosanoid transport (GO:0071715)3.16260786
76fatty acid derivative transport (GO:1901571)3.16260786
77lymph vessel development (GO:0001945)3.12576751
78glomerular visceral epithelial cell development (GO:0072015)3.12495808
79toxin metabolic process (GO:0009404)3.10895787
80endothelial cell differentiation (GO:0045446)3.10422886
81branching involved in salivary gland morphogenesis (GO:0060445)3.07786368
82polarized epithelial cell differentiation (GO:0030859)3.07269753
83phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.07233296
84negative regulation of response to reactive oxygen species (GO:1901032)3.05837753
85regulation of interleukin-13 production (GO:0032656)3.02243704
86negative regulation of interleukin-2 production (GO:0032703)3.00651057
87hormone catabolic process (GO:0042447)2.99609017
88regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.98421775
89hydrogen peroxide biosynthetic process (GO:0050665)2.97658699
90renal filtration (GO:0097205)2.97538969
91endothelial cell chemotaxis (GO:0035767)2.97489276
92calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.97209945
93branch elongation of an epithelium (GO:0060602)2.96809629
94tight junction assembly (GO:0070830)2.94952527
95negative regulation of immunoglobulin mediated immune response (GO:0002890)2.93149343
96negative regulation of B cell mediated immunity (GO:0002713)2.93149343
97norepinephrine metabolic process (GO:0042415)2.92390113
98response to thyroid hormone (GO:0097066)2.90953378
99blood vessel remodeling (GO:0001974)2.90918613
100regulation of hippo signaling (GO:0035330)2.90497301
101regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.89583687
102sphingosine metabolic process (GO:0006670)2.88431774
103positive regulation of chemokine secretion (GO:0090197)2.87951775
104apoptotic cell clearance (GO:0043277)2.87418876
105negative regulation of cytokine biosynthetic process (GO:0042036)2.87320548
106positive regulation of p38MAPK cascade (GO:1900745)2.87194174
107axis elongation (GO:0003401)2.86100162
108neuron remodeling (GO:0016322)2.85846832
109membrane raft organization (GO:0031579)2.84821060
110negative regulation of stress fiber assembly (GO:0051497)2.84387243
111establishment of epithelial cell polarity (GO:0090162)2.83687244
112protein activation cascade (GO:0072376)2.83663624
113* cellular response to nitric oxide (GO:0071732)2.83266407
114positive regulation of phagocytosis (GO:0050766)2.82123059
115T cell mediated immunity (GO:0002456)2.81725628
116cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.80337811
117renal system process involved in regulation of blood volume (GO:0001977)2.79381616
118regulation of smooth muscle cell differentiation (GO:0051150)2.75451373
119midgut development (GO:0007494)2.75381766
120mesenchymal cell proliferation (GO:0010463)2.75266922
121retina vasculature morphogenesis in camera-type eye (GO:0061299)2.74110351
122establishment of endothelial barrier (GO:0061028)2.73685780
123cell migration involved in sprouting angiogenesis (GO:0002042)2.69355520
124complement activation, alternative pathway (GO:0006957)2.68231399
125positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.68162799
126negative regulation of alcohol biosynthetic process (GO:1902931)2.66754600
127negative regulation of endothelial cell proliferation (GO:0001937)2.66569826
128lung-associated mesenchyme development (GO:0060484)2.66109008
129lung morphogenesis (GO:0060425)2.65181545
130atrioventricular valve morphogenesis (GO:0003181)2.64178532
131negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.63258356
132renal system development (GO:0072001)2.62100177
133reactive oxygen species biosynthetic process (GO:1903409)2.61535739
134regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393)2.61424581
135* cellular response to reactive nitrogen species (GO:1902170)2.61157329
136negative regulation of actin filament bundle assembly (GO:0032232)2.59934485
137coronary vasculature morphogenesis (GO:0060977)2.59251968
138toxin transport (GO:1901998)2.59037245
139Leydig cell differentiation (GO:0033327)2.58624775
140negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.57919672
141ethanol metabolic process (GO:0006067)2.56697474
142outflow tract septum morphogenesis (GO:0003148)2.56201125
143induction of positive chemotaxis (GO:0050930)2.56142922
144negative regulation of cell fate specification (GO:0009996)2.55415558
145multicellular organismal water homeostasis (GO:0050891)2.55346914
146one-carbon compound transport (GO:0019755)2.54664758
147regulation of humoral immune response (GO:0002920)2.53569794
148interleukin-6-mediated signaling pathway (GO:0070102)2.50632604
149import into cell (GO:0098657)2.47399583
150positive regulation of receptor recycling (GO:0001921)2.45485824
151arachidonic acid secretion (GO:0050482)2.44243970
152icosanoid secretion (GO:0032309)2.44243970
153prostanoid biosynthetic process (GO:0046457)2.42957347
154prostaglandin biosynthetic process (GO:0001516)2.42957347
155regulation of macrophage chemotaxis (GO:0010758)2.39818565
156regulation of chemokine secretion (GO:0090196)2.39227320
157cell volume homeostasis (GO:0006884)2.38401517
158positive regulation of type 2 immune response (GO:0002830)2.32442290
159transcytosis (GO:0045056)2.30045044
160neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.29953506
161regulation of p38MAPK cascade (GO:1900744)2.28997182
162positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.27202578
163regulation of T-helper 2 cell differentiation (GO:0045628)2.26639177
164surfactant homeostasis (GO:0043129)18.5806092
165chemical homeostasis within a tissue (GO:0048875)14.8933857

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human6.62269494
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.96011146
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.61122056
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.35233865
5CLOCK_20551151_ChIP-Seq_293T_Human3.21279618
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.16961182
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.14138170
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.13346985
9ESR1_20079471_ChIP-ChIP_T-47D_Human3.07263826
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.73399636
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.65742779
12GATA2_21666600_ChIP-Seq_HMVEC_Human2.65274372
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.63201327
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.61997587
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.56973114
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.47071524
17FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.38073751
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.33954057
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.29234606
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.21729782
21SOX2_20726797_ChIP-Seq_SW620_Human2.18801356
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.06697545
23AHR_22903824_ChIP-Seq_MCF-7_Human2.05373848
24SOX2_27498859_Chip-Seq_STOMACH_Mouse1.98889510
25PPAR_26484153_Chip-Seq_NCI-H1993_Human1.93292171
26SALL4_18804426_ChIP-ChIP_XEN_Mouse1.91274078
27CDX2_20551321_ChIP-Seq_CACO-2_Human1.90641455
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.88003929
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.82277881
30ZNF217_24962896_ChIP-Seq_MCF-7_Human1.80988226
31CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.71325192
32GATA4_25053715_ChIP-Seq_YYC3_Human1.70008914
33SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.68706146
34NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.67966494
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.62789965
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61884138
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.61313922
38CJUN_26792858_Chip-Seq_BT549_Human1.58329261
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.56907111
40TBX20_22328084_ChIP-Seq_HEART_Mouse1.56375080
41TBX20_22080862_ChIP-Seq_HEART_Mouse1.56375080
42EP300_21415370_ChIP-Seq_HL-1_Mouse1.56227915
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.55502143
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.55363425
45ARNT_22903824_ChIP-Seq_MCF-7_Human1.53587733
46BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.52237810
47TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50470896
48LXR_22158963_ChIP-Seq_LIVER_Mouse1.48663871
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46955745
50SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.46309255
51SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.46309255
52RUNX1_27514584_Chip-Seq_MCF-7_Human1.45608783
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.44215499
54HIF1A_21447827_ChIP-Seq_MCF-7_Human1.43403692
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.42031199
56RACK7_27058665_Chip-Seq_MCF-7_Human1.40881573
57SOX9_24532713_ChIP-Seq_HFSC_Mouse1.40740011
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36655290
59FOXM1_26456572_ChIP-Seq_MCF-7_Human1.35367026
60KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34262689
61TP53_18474530_ChIP-ChIP_U2OS_Human1.33612668
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.33199306
63IRF8_27001747_Chip-Seq_BMDM_Mouse1.32174430
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29046567
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28897345
66JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27223871
67EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.26317902
68NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.25036690
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.24311844
70IRF8_21731497_ChIP-ChIP_J774_Mouse1.23677349
71AR_21572438_ChIP-Seq_LNCaP_Human1.23175989
72ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21585051
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20494952
74ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.18808631
75AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.16233541
76NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15804756
77TCF4_18268006_ChIP-ChIP_LS174T_Human1.15440193
78GATA1_19941826_ChIP-Seq_K562_Human1.14360686
79SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13916688
80SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.12174052
81EZH2_22144423_ChIP-Seq_EOC_Human1.12131558
82KLF5_25053715_ChIP-Seq_YYC3_Human1.12129768
83ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11369567
84GATA3_24758297_ChIP-Seq_MCF-7_Human1.08568234
85SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.05765310
86TP63_17297297_ChIP-ChIP_HaCaT_Human1.05035423
87P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03384144
88FOXA2_19822575_ChIP-Seq_HepG2_Human1.02745471
89RUNX_20019798_ChIP-Seq_JUKART_Human1.02519503
90CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02286880
91SPI1_23127762_ChIP-Seq_K562_Human1.01644161
92SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01233556
93GATA6_25053715_ChIP-Seq_YYC3_Human1.00384466
94ISL1_27105846_Chip-Seq_CPCs_Mouse1.00217334
95KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97992571
96KDM2B_26808549_Chip-Seq_K562_Human0.97305300
97VDR_24787735_ChIP-Seq_THP-1_Human0.96925185
98NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96869435
99NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96869435
100RXR_22158963_ChIP-Seq_LIVER_Mouse0.96778582
101SMAD3_21741376_ChIP-Seq_HESCs_Human0.96626466
102TP63_23658742_ChIP-Seq_EP156T_Human0.94460208
103ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91622698
104PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91217176
105NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89955359
106JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89741970
107* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.88837000
108FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.88650269
109PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88631020
110BRD4_25478319_ChIP-Seq_HGPS_Human0.88397506
111RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88340332
112UBF1/2_26484160_Chip-Seq_HMECs_Human0.87647616
113FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86729399
114WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86203393
115IRF8_22096565_ChIP-ChIP_GC-B_Human0.86061579
116FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.85992357
117SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85935158
118GATA2_19941826_ChIP-Seq_K562_Human0.85891195
119ZNF263_19887448_ChIP-Seq_K562_Human0.84879169
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.84359672
121CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84097153
122IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.84086216
123SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.83969388
124STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.83841891
125NR3C1_23031785_ChIP-Seq_PC12_Mouse0.81012968
126PIAS1_25552417_ChIP-Seq_VCAP_Human0.79201016
127GATA1_19941827_ChIP-Seq_MEL_Mouse0.78593211
128WT1_19549856_ChIP-ChIP_CCG9911_Human0.77225316

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001958_emphysema4.42780368
2MP0010368_abnormal_lymphatic_system4.09534824
3MP0002138_abnormal_hepatobiliary_system3.87751547
4MP0005083_abnormal_biliary_tract3.68502701
5MP0008004_abnormal_stomach_pH3.59673697
6MP0001177_atelectasis3.10800360
7MP0001879_abnormal_lymphatic_vessel3.08729853
8MP0005167_abnormal_blood-brain_barrier2.80178471
9MP0003724_increased_susceptibility_to2.74670391
10* MP0002133_abnormal_respiratory_system2.69704609
11* MP0005388_respiratory_system_phenotype2.69704609
12MP0002295_abnormal_pulmonary_circulatio2.61807196
13MP0004272_abnormal_basement_membrane2.53767253
14MP0000537_abnormal_urethra_morphology2.40949958
15MP0003191_abnormal_cellular_cholesterol2.35551583
16MP0002132_abnormal_respiratory_system2.11651486
17MP0000566_synostosis2.01003677
18MP0004782_abnormal_surfactant_physiolog10.1442224
19MP0010234_abnormal_vibrissa_follicle1.91613731
20MP0009780_abnormal_chondrocyte_physiolo1.77956909
21* MP0008995_early_reproductive_senescence1.69585642
22MP0003566_abnormal_cell_adhesion1.59953769
23MP0008875_abnormal_xenobiotic_pharmacok1.56301066
24MP0003115_abnormal_respiratory_system1.52091632
25* MP0001175_abnormal_lung_morphology1.51901893
26MP0005058_abnormal_lysosome_morphology1.50022888
27MP0003690_abnormal_glial_cell1.50012952
28MP0005275_abnormal_skin_tensile1.46118598
29MP0002277_abnormal_respiratory_mucosa1.44528616
30MP0005408_hypopigmentation1.34861831
31MP0000343_altered_response_to1.33582384
32MP0002998_abnormal_bone_remodeling1.33013772
33MP0003950_abnormal_plasma_membrane1.32208589
34MP0004883_abnormal_blood_vessel1.29822261
35MP0000534_abnormal_ureter_morphology1.23550620
36MP0005164_abnormal_response_to1.23240058
37MP0003941_abnormal_skin_development1.21202251
38MP0000767_abnormal_smooth_muscle1.21143197
39MP0003705_abnormal_hypodermis_morpholog1.19695088
40MP0010678_abnormal_skin_adnexa1.18065156
41MP0006054_spinal_hemorrhage1.15814936
42MP0008438_abnormal_cutaneous_collagen1.13160627
43MP0003279_aneurysm1.11218382
44MP0000249_abnormal_blood_vessel1.10194381
45MP0005503_abnormal_tendon_morphology1.09237021
46MP0002098_abnormal_vibrissa_morphology1.06664494
47MP0005023_abnormal_wound_healing1.06091672
48MP0001986_abnormal_taste_sensitivity1.04784457
49MP0000465_gastrointestinal_hemorrhage1.03878313
50MP0005595_abnormal_vascular_smooth1.02682999
51MP0010352_gastrointestinal_tract_polyps0.99328386
52MP0005397_hematopoietic_system_phenotyp0.99125225
53MP0001545_abnormal_hematopoietic_system0.99125225
54MP0003091_abnormal_cell_migration0.98224826
55MP0006138_congestive_heart_failure0.97409272
56MP0002796_impaired_skin_barrier0.96581696
57MP0001756_abnormal_urination0.94106949
58MP0000383_abnormal_hair_follicle0.93131915
59MP0002405_respiratory_system_inflammati0.92186407
60MP0002332_abnormal_exercise_endurance0.90867671
61MP0005367_renal/urinary_system_phenotyp0.89263556
62MP0000516_abnormal_urinary_system0.89263556
63MP0003303_peritoneal_inflammation0.89221841
64MP0005025_abnormal_response_to0.88565592
65MP0002419_abnormal_innate_immunity0.85745843
66MP0000462_abnormal_digestive_system0.84593291
67MP0002139_abnormal_hepatobiliary_system0.84251261
68MP0005166_decreased_susceptibility_to0.82450250
69MP0003436_decreased_susceptibility_to0.81696895
70MP0002166_altered_tumor_susceptibility0.81665814
71MP0002925_abnormal_cardiovascular_devel0.80013467
72MP0002282_abnormal_trachea_morphology0.79904292
73MP0002909_abnormal_adrenal_gland0.79346171
74MP0002128_abnormal_blood_circulation0.78870973
75MP0005085_abnormal_gallbladder_physiolo0.77352778
76MP0003453_abnormal_keratinocyte_physiol0.77260016
77MP0001501_abnormal_sleep_pattern0.76622265
78MP0006082_CNS_inflammation0.75888537
79MP0009384_cardiac_valve_regurgitation0.73942520
80MP0001661_extended_life_span0.73755632
81MP0001533_abnormal_skeleton_physiology0.72912022
82MP0001614_abnormal_blood_vessel0.71305947
83MP0000013_abnormal_adipose_tissue0.70731755
84* MP0001943_abnormal_respiration0.70638269
85MP0005076_abnormal_cell_differentiation0.69426240
86MP0003828_pulmonary_edema0.69225794
87MP0003448_altered_tumor_morphology0.68742205
88MP0003119_abnormal_digestive_system0.66821313
89MP0003656_abnormal_erythrocyte_physiolo0.66342850
90MP0001666_abnormal_nutrient_absorption0.65668592
91MP0002733_abnormal_thermal_nociception0.65475576
92MP0005647_abnormal_sex_gland0.64931422
93MP0002118_abnormal_lipid_homeostasis0.64186762
94MP0002168_other_aberrant_phenotype0.64154510
95MP0005332_abnormal_amino_acid0.63951417
96MP0003890_abnormal_embryonic-extraembry0.63592008
97MP0003075_altered_response_to0.63074333
98MP0003300_gastrointestinal_ulcer0.63004671
99MP0001544_abnormal_cardiovascular_syste0.62844105
100MP0005385_cardiovascular_system_phenoty0.62844105
101MP0003638_abnormal_response/metabolism_0.62496339
102MP0002234_abnormal_pharynx_morphology0.62339811
103MP0004185_abnormal_adipocyte_glucose0.62211561
104MP0000681_abnormal_thyroid_gland0.60487773
105MP0010329_abnormal_lipoprotein_level0.60388515
106MP0002136_abnormal_kidney_physiology0.60146573
107MP0000627_abnormal_mammary_gland0.59833591
108MP0001664_abnormal_digestion0.59251413
109MP0005387_immune_system_phenotype0.59039050
110MP0001790_abnormal_immune_system0.59039050
111MP0002009_preneoplasia0.58330663
112MP0001849_ear_inflammation0.58040204
113MP0004947_skin_inflammation0.57949692
114MP0005248_abnormal_Harderian_gland0.57124786
115MP0009643_abnormal_urine_homeostasis0.55795507
116MP0004085_abnormal_heartbeat0.55654932
117MP0000470_abnormal_stomach_morphology0.54405420
118MP0003943_abnormal_hepatobiliary_system0.53834997
119MP0005165_increased_susceptibility_to0.53719863
120MP0001346_abnormal_lacrimal_gland0.53541530
121MP0002135_abnormal_kidney_morphology0.53384155
122MP0001542_abnormal_bone_strength0.53218536
123MP0002877_abnormal_melanocyte_morpholog0.52853832
124MP0010030_abnormal_orbit_morphology0.52612743
125MP0001853_heart_inflammation0.52392273
126MP0002933_joint_inflammation0.51762445
127* MP0001851_eye_inflammation0.51273174
128MP0009840_abnormal_foam_cell0.50896188
129MP0004084_abnormal_cardiac_muscle0.50412103
130MP0008961_abnormal_basal_metabolism0.50377571
131MP0008775_abnormal_heart_ventricle0.49464141
132MP0009764_decreased_sensitivity_to0.49312946
133MP0004484_altered_response_of0.49196395
134MP0000604_amyloidosis0.47558612
135MP0003045_fibrosis0.47383282
136MP0008469_abnormal_protein_level0.47146632

Predicted human phenotypes

RankGene SetZ-score
1* Interstitial pulmonary disease (HP:0006530)9.80241202
2Hyperactive renin-angiotensin system (HP:0000841)6.79761684
3Chronic bronchitis (HP:0004469)6.23615448
4Abnormality of the fingertips (HP:0001211)6.14737714
5Systemic lupus erythematosus (HP:0002725)5.80515804
6Renal salt wasting (HP:0000127)5.41651280
7Polycythemia (HP:0001901)5.33680540
8Glomerulonephritis (HP:0000099)5.23242267
9Complement deficiency (HP:0004431)5.21277072
10Alveolar cell carcinoma (HP:0006519)5.12347329
11Onycholysis (HP:0001806)5.01542478
12Hematochezia (HP:0002573)4.99998044
13Neoplasm of the tracheobronchial system (HP:0100552)4.74939183
14Spontaneous hematomas (HP:0007420)4.42122279
15Abnormality of complement system (HP:0005339)4.37242321
16Abnormality of the nasal mucosa (HP:0000433)4.31671933
17Gout (HP:0001997)4.29295181
18Exertional dyspnea (HP:0002875)4.16147812
19Hyperkalemia (HP:0002153)4.12592719
20* Respiratory distress (HP:0002098)4.02918384
21Neurofibrillary tangles (HP:0002185)4.00590771
22Visceral angiomatosis (HP:0100761)3.76115564
23Abnormal umbilical cord blood vessels (HP:0011403)3.75156029
24Single umbilical artery (HP:0001195)3.75156029
25Abnormality of the fetal cardiovascular system (HP:0010948)3.75156029
26* Tachypnea (HP:0002789)3.65555834
27Long toe (HP:0010511)3.60466540
28Hemangiomatosis (HP:0007461)3.53766826
29Tubulointerstitial nephritis (HP:0001970)3.52265384
30Ulnar bowing (HP:0003031)3.45114217
31Pulmonary fibrosis (HP:0002206)3.37657849
32Esophageal varix (HP:0002040)3.26739338
33Segmental peripheral demyelination/remyelination (HP:0003481)3.18838943
34Bronchitis (HP:0012387)3.17993504
35Cerebral inclusion bodies (HP:0100314)3.12901991
36Chronic otitis media (HP:0000389)3.11787355
37Broad metatarsal (HP:0001783)3.09884858
38Hyperaldosteronism (HP:0000859)3.08976897
39Cerebral aneurysm (HP:0004944)3.06277997
40Hypotension (HP:0002615)3.03327593
41Hypergammaglobulinemia (HP:0010702)2.99689350
42Ulnar claw (HP:0001178)2.97447412
43Abnormality of chloride homeostasis (HP:0011422)2.86147233
44* Tubulointerstitial fibrosis (HP:0005576)2.81784439
45Neoplasm of the lung (HP:0100526)2.81531912
46Fragile nails (HP:0001808)2.75353932
47Conjunctival telangiectasia (HP:0000524)2.69321788
48Abnormality of renin-angiotensin system (HP:0000847)2.68697936
49Pulmonary hypertension (HP:0002092)2.68384088
50Cerebral hemorrhage (HP:0001342)2.68095538
51Glucose intolerance (HP:0000833)2.67164818
52Decreased circulating renin level (HP:0003351)2.62777406
53Bronchomalacia (HP:0002780)2.58616236
54Osteolytic defects of the hand bones (HP:0009699)2.58356928
55Osteolytic defects of the phalanges of the hand (HP:0009771)2.58356928
56Milia (HP:0001056)2.53522413
57Atrophic scars (HP:0001075)2.52590793
58Growth hormone excess (HP:0000845)2.52262347
59Stomach cancer (HP:0012126)2.52061405
60Tubular atrophy (HP:0000092)2.50189450
61Neonatal respiratory distress (HP:0002643)2.49741727
62Hyperpituitarism (HP:0010514)2.48206581
63Subcapsular cataract (HP:0000523)2.46088596
64Neoplasm of the respiratory system (HP:0100606)2.42021874
65Supranuclear gaze palsy (HP:0000605)2.40955226
66Thyroid-stimulating hormone excess (HP:0002925)2.40241605
67Bowed forearm bones (HP:0003956)2.38359485
68Bowing of the arm (HP:0006488)2.38359485
69Loss of speech (HP:0002371)2.37272517
70Abnormality of the vasculature of the conjunctiva (HP:0008054)2.37070885
71Potter facies (HP:0002009)2.36741068
72Facial shape deformation (HP:0011334)2.36741068
73Posterior subcapsular cataract (HP:0007787)2.36266600
74Increased CSF protein (HP:0002922)2.35928134
75Deep venous thrombosis (HP:0002625)2.32925132
76Distal lower limb muscle weakness (HP:0009053)2.32854328
77Midline defect of the nose (HP:0004122)2.31704174
78Restrictive lung disease (HP:0002091)2.30662539
79Shawl scrotum (HP:0000049)2.26282394
80Stenosis of the external auditory canal (HP:0000402)2.23648952
81Subacute progressive viral hepatitis (HP:0006572)2.22154616
82Arterial tortuosity (HP:0005116)2.19550886
83Microcytic anemia (HP:0001935)2.19241396
84Recurrent abscess formation (HP:0002722)2.16559992
85Cavernous hemangioma (HP:0001048)2.16097793
86Hyponatremia (HP:0002902)2.15401044
87Shallow orbits (HP:0000586)2.15266857
88Vascular tortuosity (HP:0004948)2.13842387
89Glomerulosclerosis (HP:0000096)2.12975430
90Intestinal atresia (HP:0011100)2.12181800
91Recurrent gram-negative bacterial infections (HP:0005420)2.11772133
92Striae distensae (HP:0001065)2.10068223
93Pulmonary artery stenosis (HP:0004415)2.09048483
94Hypokalemic alkalosis (HP:0001949)2.07850662
95Flexion contracture of toe (HP:0005830)2.07528407
96Joint contractures involving the joints of the feet (HP:0100492)2.07528407
97Abnormality of the umbilical cord (HP:0010881)2.04643573
98Camptodactyly of toe (HP:0001836)2.02304814
99Seborrheic dermatitis (HP:0001051)1.96722192
100Bronchiectasis (HP:0002110)1.96424384
101Megalencephaly (HP:0001355)1.96356613
102Annular pancreas (HP:0001734)1.95526994
103Joint swelling (HP:0001386)1.93670168
104Increased purine levels (HP:0004368)1.92498440
105Hyperuricemia (HP:0002149)1.92498440
106Rectal prolapse (HP:0002035)1.91296094
107Abnormality of macrophages (HP:0004311)1.89690336
108Progressive sensorineural hearing impairment (HP:0000408)1.89490655
109Plantar hyperkeratosis (HP:0007556)1.89237972
110Aplasia involving bones of the upper limbs (HP:0009823)1.87611023
111Aplasia of the phalanges of the hand (HP:0009802)1.87611023
112Aplasia involving bones of the extremities (HP:0009825)1.87611023
113Mucosal telangiectasiae (HP:0100579)1.84657334
114Polar cataract (HP:0010696)1.84520303
115Synostosis involving the elbow (HP:0003938)1.83831518
116Humeroradial synostosis (HP:0003041)1.83831518
117Aortic aneurysm (HP:0004942)1.82734299
118Abnormal glucose tolerance (HP:0001952)1.81785111
119Eczematoid dermatitis (HP:0000976)1.81126965
120Rapidly progressive (HP:0003678)1.80716055
121Nephritis (HP:0000123)1.78953760
122Abnormality of the gastric mucosa (HP:0004295)1.76608305
123Purpura (HP:0000979)1.75593878
124Broad distal phalanx of finger (HP:0009836)1.74759093
125Skin nodule (HP:0200036)1.74589765
126Myocardial infarction (HP:0001658)1.74494996
127Reduced subcutaneous adipose tissue (HP:0003758)1.73127447
128Wormian bones (HP:0002645)1.73046638
129Abnormality of the pulmonary veins (HP:0011718)1.72703301
130Absent eyebrow (HP:0002223)1.72440455
131Flat capital femoral epiphysis (HP:0003370)1.72191585
132Right ventricular cardiomyopathy (HP:0011663)1.70902593
133Prostate neoplasm (HP:0100787)1.69607164
134Onion bulb formation (HP:0003383)1.67056810
135Increased connective tissue (HP:0009025)1.65771909
136Difficulty walking (HP:0002355)1.62902708
137Adrenal overactivity (HP:0002717)1.59005633
138Mucopolysacchariduria (HP:0008155)1.58883186
139Urinary glycosaminoglycan excretion (HP:0003541)1.58883186
140Absent hand (HP:0004050)1.56442772
141Cerebral palsy (HP:0100021)1.56228202
142Aneurysm (HP:0002617)1.55778874
143Adactyly (HP:0009776)1.54533127
144Abnormality of mucopolysaccharide metabolism (HP:0011020)1.48138762
145Abnormality of polysaccharide metabolism (HP:0011012)1.48138762
146Abnormality of glycosaminoglycan metabolism (HP:0004371)1.48138762
147Mitral valve prolapse (HP:0001634)1.47969425
148Bone cyst (HP:0012062)1.46799280

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.09455356
2TGFBR24.25944333
3FGFR24.16231813
4STK243.78868893
5LRRK23.29438900
6PAK42.74157080
7EPHB22.57081859
8MST42.33584225
9ZAP702.23809157
10DAPK22.22537592
11RIPK12.13617361
12LMTK22.12588401
13EPHB12.06971064
14GRK12.04388368
15TRIB31.98639396
16ILK1.98546252
17EPHA21.91684195
18MAP3K31.90795578
19STK101.87976216
20MAP3K61.83796448
21FER1.79140988
22PDGFRB1.70749181
23TESK11.69841127
24CDC42BPA1.65315830
25NLK1.62536973
26MAP3K21.61812336
27MYLK1.59746589
28RPS6KA21.58241457
29FGFR41.53943087
30PRPF4B1.53679343
31PTK61.50538742
32MARK21.48752897
33TGFBR11.40845899
34STK38L1.35674828
35AKT31.29680300
36ERN11.28906666
37MST1R1.28664911
38MAP3K121.26987872
39LATS21.25052965
40MAP3K141.23029040
41LATS11.20667836
42MAPK71.13788049
43CSK1.11118387
44MAPK121.09636363
45KDR1.08702997
46PDGFRA1.07800229
47MAPK151.07276684
48MET1.06437283
49BCR1.06059886
50YES11.04544343
51IRAK11.04114235
52LIMK11.02999889
53HIPK20.96024671
54NTRK30.89826309
55BLK0.87567747
56GSK3A0.87471502
57CDK60.87007072
58FRK0.86856379
59FGFR30.85960578
60NEK90.82944814
61EPHA30.81643791
62SGK20.80872805
63CAMK1D0.80482120
64PTK20.78748778
65EGFR0.72195254
66PTK2B0.69642241
67RET0.66545779
68PRKD10.65519933
69TTN0.64873008
70MAP2K30.63501345
71KIT0.63311323
72PDK20.62873430
73PRKCQ0.60934965
74SGK2230.60651398
75SGK4940.60651398
76ERBB30.60178739
77KSR20.60107437
78TAOK30.59804673
79DAPK10.58179935
80RPS6KA40.56154324
81GRK50.56148738
82DDR20.55118257
83JAK20.54588071
84STK380.54386377
85TYK20.53770727
86MAPKAPK30.53353666
87MATK0.51950707
88MAP3K90.51776247
89INSR0.50698684
90MAPKAPK20.49127532
91CHUK0.48409152
92DAPK30.47983800
93NME10.46442436
94ERBB20.46339342
95MAP2K20.46251433
96MOS0.44508174
97MAPK40.44418288
98PRKG20.44333846
99GRK70.44301212
100NEK60.44291756
101MAP2K10.44079091
102PDK10.43501129
103SIK10.43450847
104ROCK10.43170084
105PRKCH0.43032099
106MAPK30.42839078
107MAP3K130.42195710
108PDPK10.40663223
109JAK10.40453752
110MAP3K10.40267302
111ROCK20.39812747
112FGFR10.38536447
113MTOR0.38502486
114NTRK10.38244677
115DMPK0.37813429
116SGK30.37593913
117TEC0.35218647
118EEF2K0.35049930
119BRSK20.35013372
120RPS6KA10.34527122
121MAP3K70.33782212
122TBK10.32489062
123PKN20.31992222
124TRPM70.30392910
125WNK40.30128330
126RPS6KL10.28574493
127RPS6KC10.28574493
128FGR0.28219475
129MARK30.27469329
130PRKCE0.27260728
131IGF1R0.27082564
132ABL10.26221854
133RPS6KA60.26107409
134IKBKE0.25862674
135SRC0.23990519
136FYN0.23691533
137PRKCD0.23504838
138STK390.22310024
139CAMK1G0.21295797

Predicted pathways (KEGG)

RankGene SetZ-score
1Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049603.09253269
2Mineral absorption_Homo sapiens_hsa049782.91965902
3ECM-receptor interaction_Homo sapiens_hsa045122.88196871
4Caffeine metabolism_Homo sapiens_hsa002322.67679566
5Adherens junction_Homo sapiens_hsa045202.65156226
6Leukocyte transendothelial migration_Homo sapiens_hsa046702.52263445
7Tight junction_Homo sapiens_hsa045302.39803414
8Asthma_Homo sapiens_hsa053102.16015588
9Lysosome_Homo sapiens_hsa041422.04724880
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.03473109
11Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.99562644
12Phagosome_Homo sapiens_hsa041451.97089900
13Graft-versus-host disease_Homo sapiens_hsa053321.89695100
14Focal adhesion_Homo sapiens_hsa045101.86841600
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.86572155
16Allograft rejection_Homo sapiens_hsa053301.79420625
17Pertussis_Homo sapiens_hsa051331.79374970
18Fatty acid biosynthesis_Homo sapiens_hsa000611.78481018
19Autoimmune thyroid disease_Homo sapiens_hsa053201.69816387
20Hippo signaling pathway_Homo sapiens_hsa043901.68478887
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.68384880
22Bladder cancer_Homo sapiens_hsa052191.66913842
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.60449515
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.56976601
25Small cell lung cancer_Homo sapiens_hsa052221.50228223
26Amoebiasis_Homo sapiens_hsa051461.49783703
27Selenocompound metabolism_Homo sapiens_hsa004501.49093325
28Renin-angiotensin system_Homo sapiens_hsa046141.48908130
29Malaria_Homo sapiens_hsa051441.43929825
30Leishmaniasis_Homo sapiens_hsa051401.38133192
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.37998577
32TGF-beta signaling pathway_Homo sapiens_hsa043501.35167337
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.32266324
34Type I diabetes mellitus_Homo sapiens_hsa049401.30492920
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.26770995
36Other glycan degradation_Homo sapiens_hsa005111.26699962
37Vibrio cholerae infection_Homo sapiens_hsa051101.26542815
38Rap1 signaling pathway_Homo sapiens_hsa040151.25072624
39Tryptophan metabolism_Homo sapiens_hsa003801.24523109
40Proteoglycans in cancer_Homo sapiens_hsa052051.23664923
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22461114
42Platelet activation_Homo sapiens_hsa046111.20215373
43Thyroid cancer_Homo sapiens_hsa052161.19884197
44Complement and coagulation cascades_Homo sapiens_hsa046101.18200975
45Regulation of actin cytoskeleton_Homo sapiens_hsa048101.15996783
46Renal cell carcinoma_Homo sapiens_hsa052111.14883619
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13211527
48Axon guidance_Homo sapiens_hsa043601.09476040
49Fatty acid degradation_Homo sapiens_hsa000711.08576272
50Toxoplasmosis_Homo sapiens_hsa051451.07853161
51Hepatitis C_Homo sapiens_hsa051601.04554006
52Histidine metabolism_Homo sapiens_hsa003401.02936940
53Pancreatic cancer_Homo sapiens_hsa052121.02269982
54Endocytosis_Homo sapiens_hsa041440.99241476
55VEGF signaling pathway_Homo sapiens_hsa043700.98494028
56Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98284480
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97230041
58Circadian rhythm_Homo sapiens_hsa047100.93032544
59Renin secretion_Homo sapiens_hsa049240.92214148
60Viral myocarditis_Homo sapiens_hsa054160.91301411
61Fatty acid elongation_Homo sapiens_hsa000620.90687704
62Linoleic acid metabolism_Homo sapiens_hsa005910.90062528
63Rheumatoid arthritis_Homo sapiens_hsa053230.88572547
64Pathways in cancer_Homo sapiens_hsa052000.88070230
65Staphylococcus aureus infection_Homo sapiens_hsa051500.85779855
66Osteoclast differentiation_Homo sapiens_hsa043800.85558060
67Arachidonic acid metabolism_Homo sapiens_hsa005900.83286949
68Phenylalanine metabolism_Homo sapiens_hsa003600.83171226
69Taste transduction_Homo sapiens_hsa047420.82870508
70Chemical carcinogenesis_Homo sapiens_hsa052040.81777994
71Ether lipid metabolism_Homo sapiens_hsa005650.81298454
72Salmonella infection_Homo sapiens_hsa051320.80997944
73Gastric acid secretion_Homo sapiens_hsa049710.80730884
74Glutathione metabolism_Homo sapiens_hsa004800.80216456
75Hematopoietic cell lineage_Homo sapiens_hsa046400.78140952
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.76948772
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76926711
78Endometrial cancer_Homo sapiens_hsa052130.76699053
79Dilated cardiomyopathy_Homo sapiens_hsa054140.76266282
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.74988394
81GnRH signaling pathway_Homo sapiens_hsa049120.72919422
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72821127
83Chronic myeloid leukemia_Homo sapiens_hsa052200.70690176
84PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70042795
85Influenza A_Homo sapiens_hsa051640.68732242
86Tyrosine metabolism_Homo sapiens_hsa003500.68684573
87Basal cell carcinoma_Homo sapiens_hsa052170.67259580
88Thyroid hormone synthesis_Homo sapiens_hsa049180.65812640
89Dorso-ventral axis formation_Homo sapiens_hsa043200.64768570
90Notch signaling pathway_Homo sapiens_hsa043300.64384485
91Choline metabolism in cancer_Homo sapiens_hsa052310.63115785
92Fatty acid metabolism_Homo sapiens_hsa012120.62689688
93Apoptosis_Homo sapiens_hsa042100.62327266
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61536407
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.61077195
96Shigellosis_Homo sapiens_hsa051310.59687418
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59562759
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59510994
99beta-Alanine metabolism_Homo sapiens_hsa004100.58941189
100ABC transporters_Homo sapiens_hsa020100.57380794
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.55735267
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.54834655
103Bile secretion_Homo sapiens_hsa049760.54634885
104MicroRNAs in cancer_Homo sapiens_hsa052060.54588015
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54524278
106Salivary secretion_Homo sapiens_hsa049700.53359396
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52736898
108Melanogenesis_Homo sapiens_hsa049160.52547912
109PPAR signaling pathway_Homo sapiens_hsa033200.52375238
110Prion diseases_Homo sapiens_hsa050200.51853651
111MAPK signaling pathway_Homo sapiens_hsa040100.51302869
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.50324588
113Collecting duct acid secretion_Homo sapiens_hsa049660.49043824
114Serotonergic synapse_Homo sapiens_hsa047260.48932694
115TNF signaling pathway_Homo sapiens_hsa046680.48886232
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.47945491
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47510171
118Colorectal cancer_Homo sapiens_hsa052100.46931373
119Oxytocin signaling pathway_Homo sapiens_hsa049210.46669704
120Prostate cancer_Homo sapiens_hsa052150.46102062
121Long-term depression_Homo sapiens_hsa047300.45936246
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45933174
123Protein digestion and absorption_Homo sapiens_hsa049740.45135691
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44406243
125Acute myeloid leukemia_Homo sapiens_hsa052210.42562918
126Sphingolipid metabolism_Homo sapiens_hsa006000.42329587
127Gap junction_Homo sapiens_hsa045400.42037079
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41849911
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41245742
130Herpes simplex infection_Homo sapiens_hsa051680.40746405
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40189413
132Peroxisome_Homo sapiens_hsa041460.40162670
133Melanoma_Homo sapiens_hsa052180.39635391
134Systemic lupus erythematosus_Homo sapiens_hsa053220.39626844
135Estrogen signaling pathway_Homo sapiens_hsa049150.38069125
136Insulin resistance_Homo sapiens_hsa049310.37620227
137Antigen processing and presentation_Homo sapiens_hsa046120.37334679
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37039156
139Ovarian steroidogenesis_Homo sapiens_hsa049130.35673904
140Ras signaling pathway_Homo sapiens_hsa040140.35278344
141Tuberculosis_Homo sapiens_hsa051520.34763585

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