SFTPD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is part of the innate immune response, protecting the lungs against inhaled microorganisms and chemicals. The encoded protein may also be involved in surfactant metabolism. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of complement activation (GO:0045916)8.05485369
2negative regulation of protein activation cascade (GO:2000258)7.45874461
3negative regulation of humoral immune response (GO:0002921)6.79415099
4pattern specification involved in kidney development (GO:0061004)6.51631284
5response to xenobiotic stimulus (GO:0009410)6.38265962
6peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)6.27712401
7cellular response to nitric oxide (GO:0071732)6.26080581
8positive regulation of endothelial cell differentiation (GO:0045603)5.96038458
9lung lobe morphogenesis (GO:0060463)5.77460390
10positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003605.59907606
11regulation of endothelial cell differentiation (GO:0045601)5.55142344
12morphogenesis of an endothelium (GO:0003159)5.23736516
13endothelial tube morphogenesis (GO:0061154)5.23736516
14cellular response to reactive nitrogen species (GO:1902170)4.87492894
15dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.86696176
16response to nitric oxide (GO:0071731)4.63831910
17regulation of vasculogenesis (GO:2001212)4.61410539
18phosphate ion transmembrane transport (GO:0035435)4.33422369
19regulation of complement activation (GO:0030449)4.22494177
20sodium-independent organic anion transport (GO:0043252)4.19199044
21regulation of phospholipid biosynthetic process (GO:0071071)4.14954389
22establishment of apical/basal cell polarity (GO:0035089)4.14234210
23epithelial tube branching involved in lung morphogenesis (GO:0060441)4.13577866
24mesodermal cell differentiation (GO:0048333)4.07431170
25phosphate ion homeostasis (GO:0055062)4.03261979
26trivalent inorganic anion homeostasis (GO:0072506)4.03261979
27lung vasculature development (GO:0060426)4.02865743
28regulation of protein activation cascade (GO:2000257)3.98777937
29blood vessel maturation (GO:0001955)3.96811732
30epithelial cell differentiation involved in prostate gland development (GO:0060742)3.94558931
31peptide catabolic process (GO:0043171)3.93866996
32virion attachment to host cell (GO:0019062)3.91304035
33adhesion of symbiont to host cell (GO:0044650)3.91304035
34cellular response to thyroid hormone stimulus (GO:0097067)3.90257813
35respiratory tube development (GO:0030323)3.88062620
36hemidesmosome assembly (GO:0031581)3.78541165
37one-carbon compound transport (GO:0019755)3.74235712
38renal absorption (GO:0070293)3.71927148
39negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.68895785
40membrane protein proteolysis (GO:0033619)3.68534970
41cellular anion homeostasis (GO:0030002)3.68500242
42regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.65024499
43lymphangiogenesis (GO:0001946)3.63861455
44protein localization to endosome (GO:0036010)3.62516159
45sodium ion homeostasis (GO:0055078)3.61614611
46induction of positive chemotaxis (GO:0050930)3.59043421
47cell adhesion mediated by integrin (GO:0033627)3.55813927
48phosphate ion transport (GO:0006817)3.54872177
49establishment or maintenance of monopolar cell polarity (GO:0061339)3.52632126
50establishment of monopolar cell polarity (GO:0061162)3.52632126
51complement activation, classical pathway (GO:0006958)3.51239967
52iron ion import (GO:0097286)3.46173764
53complement activation (GO:0006956)3.46091262
54negative regulation of immunoglobulin mediated immune response (GO:0002890)3.45334719
55negative regulation of B cell mediated immunity (GO:0002713)3.45334719
56cellular hyperosmotic response (GO:0071474)3.44383347
57hyperosmotic salinity response (GO:0042538)3.41309956
58gas transport (GO:0015669)3.41018401
59negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.40354243
60endocrine hormone secretion (GO:0060986)3.39903646
61positive regulation of digestive system process (GO:0060456)3.35171403
62polyol transport (GO:0015791)3.32952266
63adhesion of symbiont to host (GO:0044406)3.32207944
64endocardial cushion development (GO:0003197)3.31814533
65positive regulation of chemokine secretion (GO:0090197)3.31342205
66regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.30398702
67regulation of glomerular filtration (GO:0003093)3.29021112
68regulation of interleukin-13 production (GO:0032656)3.28547320
69embryonic foregut morphogenesis (GO:0048617)3.27082206
70negative regulation of response to reactive oxygen species (GO:1901032)3.25755240
71* respiratory gaseous exchange (GO:0007585)3.24710365
72positive regulation of vasculogenesis (GO:2001214)3.23812924
73response to vitamin A (GO:0033189)3.18177685
74neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.17626211
75toxin transport (GO:1901998)3.16373793
76hormone catabolic process (GO:0042447)3.08654253
77glomerular epithelial cell development (GO:0072310)3.08451038
78positive regulation of p38MAPK cascade (GO:1900745)3.05211646
79regulation of chemokine secretion (GO:0090196)3.03295327
80vascular endothelial growth factor signaling pathway (GO:0038084)3.03092180
81sphingosine metabolic process (GO:0006670)3.01041206
82negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.00732295
83regulation of hippo signaling (GO:0035330)3.00686969
84response to thyroid hormone (GO:0097066)3.00057305
85negative regulation of fatty acid transport (GO:2000192)2.98067630
86regulation of integrin-mediated signaling pathway (GO:2001044)2.97188773
87glomerular filtration (GO:0003094)2.96878182
88protein activation cascade (GO:0072376)2.95343267
89negative regulation of transcription by competitive promoter binding (GO:0010944)2.95116031
90branching involved in salivary gland morphogenesis (GO:0060445)2.94527974
91segment specification (GO:0007379)2.92215367
92artery development (GO:0060840)2.91476636
93phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.91107912
94renal filtration (GO:0097205)2.90230723
95long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.90088641
96polarized epithelial cell differentiation (GO:0030859)2.88690609
97response to hyperoxia (GO:0055093)2.86896147
98response to increased oxygen levels (GO:0036296)2.86896147
99ethanol oxidation (GO:0006069)2.86513092
100multicellular organismal water homeostasis (GO:0050891)2.85773769
101cellular response to antibiotic (GO:0071236)2.85390113
102endothelial cell chemotaxis (GO:0035767)2.82141244
103toxin metabolic process (GO:0009404)2.81446294
104negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.79039566
105regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.78703957
106endothelial cell differentiation (GO:0045446)2.77986738
107neuron remodeling (GO:0016322)2.76958313
108response to interleukin-6 (GO:0070741)2.76645136
109Leydig cell differentiation (GO:0033327)2.76553533
110apoptotic cell clearance (GO:0043277)2.76479904
111wound healing, spreading of epidermal cells (GO:0035313)2.74641293
112branch elongation of an epithelium (GO:0060602)2.74481376
113negative regulation of alcohol biosynthetic process (GO:1902931)2.74060318
114regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.74045702
115negative regulation of stress fiber assembly (GO:0051497)2.73869615
116regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.72454243
117retina vasculature morphogenesis in camera-type eye (GO:0061299)2.72331165
118extracellular matrix assembly (GO:0085029)2.71249674
119T cell mediated immunity (GO:0002456)2.70683147
120cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.70544094
121lung secretory cell differentiation (GO:0061140)2.70069352
122establishment of epithelial cell polarity (GO:0090162)2.69940739
123establishment of endothelial barrier (GO:0061028)2.68594438
124tight junction assembly (GO:0070830)2.67818327
125renal system process involved in regulation of blood volume (GO:0001977)2.67783090
126blood vessel remodeling (GO:0001974)2.67482877
127axis elongation (GO:0003401)2.67195312
128norepinephrine metabolic process (GO:0042415)2.66649883
129regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.65475853
130regulation of humoral immune response (GO:0002920)2.64757539
131receptor catabolic process (GO:0032801)2.62970628
132icosanoid transport (GO:0071715)2.62440975
133fatty acid derivative transport (GO:1901571)2.62440975
134negative regulation of cell fate specification (GO:0009996)2.61003247
135import into cell (GO:0098657)2.59061850
136diol metabolic process (GO:0034311)2.57952475
137fatty-acyl-CoA biosynthetic process (GO:0046949)2.57097317
138regulation of p38MAPK cascade (GO:1900744)2.56090213
139transcytosis (GO:0045056)2.54876025
140membrane raft organization (GO:0031579)2.53152554
141calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.52472482
142regulation of macrophage chemotaxis (GO:0010758)2.49463009
143hydrogen peroxide biosynthetic process (GO:0050665)2.46871195
144positive regulation of receptor recycling (GO:0001921)2.44960377
145interleukin-6-mediated signaling pathway (GO:0070102)2.40969648
146negative regulation of actin filament bundle assembly (GO:0032232)2.37608039
147atrioventricular valve morphogenesis (GO:0003181)2.36549863
148protein autoprocessing (GO:0016540)2.35239268
149folic acid transport (GO:0015884)2.29951166
150lipoxygenase pathway (GO:0019372)2.22757822
151positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.18843111
152cellular sodium ion homeostasis (GO:0006883)2.16822857
153regulation of metalloenzyme activity (GO:0048552)2.15516640
154amyloid precursor protein catabolic process (GO:0042987)2.15080986
155reactive oxygen species biosynthetic process (GO:1903409)2.14854519
156regulation of cholesterol storage (GO:0010885)2.12098312
157* surfactant homeostasis (GO:0043129)13.8164888
158* chemical homeostasis within a tissue (GO:0048875)10.6728154

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human4.36340102
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.88646149
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.87382069
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.43115467
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.18588119
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.17556995
7RARG_19884340_ChIP-ChIP_MEFs_Mouse3.08953518
8CLOCK_20551151_ChIP-Seq_293T_Human2.95209132
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.93975624
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.87647547
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.82383225
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.62218697
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.51383371
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48768645
15GATA2_21666600_ChIP-Seq_HMVEC_Human2.40571571
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.32426534
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.27278605
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.21062822
19SOX2_20726797_ChIP-Seq_SW620_Human2.13431807
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.13097850
21FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.98687288
22CDX2_20551321_ChIP-Seq_CACO-2_Human1.97491870
23SOX2_27498859_Chip-Seq_STOMACH_Mouse1.97374204
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.95941721
25PPAR_26484153_Chip-Seq_NCI-H1993_Human1.87952133
26* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.82830419
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.82365146
28AHR_22903824_ChIP-Seq_MCF-7_Human1.80371511
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76488507
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.70421531
31SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.69844015
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67777907
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.65883921
34GATA4_25053715_ChIP-Seq_YYC3_Human1.64663159
35LXR_22158963_ChIP-Seq_LIVER_Mouse1.63408102
36RACK7_27058665_Chip-Seq_MCF-7_Human1.63159009
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62905047
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.59102776
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57670932
40CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.57623308
41RUNX1_27514584_Chip-Seq_MCF-7_Human1.53341068
42ZNF263_19887448_ChIP-Seq_K562_Human1.50405117
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.49098145
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.48213829
45TBX20_22080862_ChIP-Seq_HEART_Mouse1.47023291
46TBX20_22328084_ChIP-Seq_HEART_Mouse1.47023291
47KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46466761
48SOX9_24532713_ChIP-Seq_HFSC_Mouse1.44859866
49AR_21572438_ChIP-Seq_LNCaP_Human1.44138200
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43706801
51ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.43642719
52EP300_21415370_ChIP-Seq_HL-1_Mouse1.43463535
53NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.41676058
54* FOXO3_23340844_ChIP-Seq_DLD1_Human1.40745134
55IRF8_27001747_Chip-Seq_BMDM_Mouse1.40617420
56SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.40548978
57SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.40548978
58IRF8_21731497_ChIP-ChIP_J774_Mouse1.39504842
59* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.39314275
60ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39173774
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36370738
62ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35420374
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.34023297
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.33232588
65PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.32462689
66Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.31763448
67* CJUN_26792858_Chip-Seq_BT549_Human1.31606420
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31393671
69EZH2_22144423_ChIP-Seq_EOC_Human1.29577387
70RXR_22158963_ChIP-Seq_LIVER_Mouse1.28363514
71NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.26523652
72JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22911395
73TP53_18474530_ChIP-ChIP_U2OS_Human1.21982010
74CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20859846
75NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20665946
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20407152
77ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19454174
78PPARA_22158963_ChIP-Seq_LIVER_Mouse1.17356544
79EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16938958
80KLF5_25053715_ChIP-Seq_YYC3_Human1.16142575
81ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16070802
82STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15335017
83P63_26484246_Chip-Seq_KERATINOCYTES_Human1.13248077
84IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.11897722
85SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10655254
86KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10525223
87KDM2B_26808549_Chip-Seq_K562_Human1.10439062
88AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10381431
89FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09931896
90GATA6_25053715_ChIP-Seq_YYC3_Human1.09541424
91SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.08119390
92GATA1_19941826_ChIP-Seq_K562_Human1.06982122
93GATA3_24758297_ChIP-Seq_MCF-7_Human1.06598485
94SMAD3_21741376_ChIP-Seq_HESCs_Human1.06194255
95FOXA2_19822575_ChIP-Seq_HepG2_Human1.00347976
96IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99512242
97FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97940941
98LXR_22292898_ChIP-Seq_THP-1_Human0.97893230
99NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96538304
100NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96538304
101FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.96417715
102NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96145087
103P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96016065
104NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94563264
105SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94554511
106VDR_24787735_ChIP-Seq_THP-1_Human0.94358096
107SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.93601844
108TCF4_18268006_ChIP-ChIP_LS174T_Human0.92943592
109MTF2_20144788_ChIP-Seq_MESCs_Mouse0.92862971
110IRF8_22096565_ChIP-ChIP_GC-B_Human0.92546434
111GATA1_19941827_ChIP-Seq_MEL_Mouse0.92493364
112TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92475989
113RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91861020
114JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91539840
115FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.89617570
116CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89311194
117SMAD4_21741376_ChIP-Seq_HESCs_Human0.87898976
118RUNX_20019798_ChIP-Seq_JUKART_Human0.87589983
119PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86400893
120UBF1/2_26484160_Chip-Seq_HMECs_Human0.86374951
121TP63_23658742_ChIP-Seq_EP156T_Human0.86219189
122WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86171735
123GATA2_19941826_ChIP-Seq_K562_Human0.85487167
124* SPI1_23127762_ChIP-Seq_K562_Human0.85342079
125CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84998620
126CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.81114720

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0004782_abnormal_surfactant_physiolog7.84451151
2MP0008995_early_reproductive_senescence4.59652213
3MP0005083_abnormal_biliary_tract4.58235378
4MP0008004_abnormal_stomach_pH3.94757120
5* MP0001958_emphysema3.82292265
6MP0010368_abnormal_lymphatic_system3.73829937
7MP0002138_abnormal_hepatobiliary_system3.49505945
8MP0001542_abnormal_bone_strength3.18738460
9MP0003724_increased_susceptibility_to3.12759340
10MP0001177_atelectasis2.96908351
11MP0010234_abnormal_vibrissa_follicle2.88474612
12MP0002295_abnormal_pulmonary_circulatio2.74741078
13MP0005167_abnormal_blood-brain_barrier2.72279134
14MP0001879_abnormal_lymphatic_vessel2.62509352
15* MP0005388_respiratory_system_phenotype2.51184681
16* MP0002133_abnormal_respiratory_system2.51184681
17MP0000537_abnormal_urethra_morphology2.48453077
18MP0003191_abnormal_cellular_cholesterol2.43473748
19MP0002132_abnormal_respiratory_system2.19759722
20MP0008875_abnormal_xenobiotic_pharmacok2.08708672
21MP0000566_synostosis1.97248173
22MP0004272_abnormal_basement_membrane1.93343316
23MP0001440_abnormal_grooming_behavior1.90672489
24MP0003566_abnormal_cell_adhesion1.65228529
25MP0002277_abnormal_respiratory_mucosa1.62851222
26MP0005058_abnormal_lysosome_morphology1.52452217
27MP0003690_abnormal_glial_cell1.42882438
28MP0009780_abnormal_chondrocyte_physiolo1.34860055
29MP0002998_abnormal_bone_remodeling1.34684273
30MP0006054_spinal_hemorrhage1.31544708
31MP0002139_abnormal_hepatobiliary_system1.31494393
32* MP0001175_abnormal_lung_morphology1.31154385
33MP0003115_abnormal_respiratory_system1.30389190
34MP0000343_altered_response_to1.27801820
35MP0010678_abnormal_skin_adnexa1.24676691
36MP0005164_abnormal_response_to1.23642225
37MP0003950_abnormal_plasma_membrane1.20398512
38MP0005275_abnormal_skin_tensile1.20053702
39MP0004883_abnormal_blood_vessel1.18438032
40MP0003303_peritoneal_inflammation1.15181759
41* MP0002405_respiratory_system_inflammati1.14181949
42MP0000534_abnormal_ureter_morphology1.13823519
43MP0005085_abnormal_gallbladder_physiolo1.13067947
44MP0002098_abnormal_vibrissa_morphology1.10844163
45MP0001851_eye_inflammation1.10494379
46MP0000249_abnormal_blood_vessel1.10010867
47MP0005023_abnormal_wound_healing1.08907281
48MP0005166_decreased_susceptibility_to1.06847549
49MP0005408_hypopigmentation1.05637419
50MP0002796_impaired_skin_barrier1.05611234
51MP0000767_abnormal_smooth_muscle1.05542491
52MP0000465_gastrointestinal_hemorrhage1.04419080
53MP0003300_gastrointestinal_ulcer1.03570197
54MP0001881_abnormal_mammary_gland0.99860379
55MP0002909_abnormal_adrenal_gland0.99339033
56MP0001756_abnormal_urination0.99334677
57MP0003786_premature_aging0.99192400
58MP0009840_abnormal_foam_cell0.98930191
59MP0003453_abnormal_keratinocyte_physiol0.94383273
60MP0005595_abnormal_vascular_smooth0.93188438
61MP0002234_abnormal_pharynx_morphology0.91689139
62MP0001666_abnormal_nutrient_absorption0.91549086
63MP0005503_abnormal_tendon_morphology0.90259940
64MP0003279_aneurysm0.89609441
65MP0006138_congestive_heart_failure0.89500627
66MP0003705_abnormal_hypodermis_morpholog0.89234401
67MP0001664_abnormal_digestion0.88975509
68MP0003091_abnormal_cell_migration0.87838424
69MP0003075_altered_response_to0.87409349
70MP0000627_abnormal_mammary_gland0.84900167
71MP0004185_abnormal_adipocyte_glucose0.83380334
72MP0000604_amyloidosis0.82760569
73MP0000462_abnormal_digestive_system0.82055650
74MP0003448_altered_tumor_morphology0.80771074
75MP0010329_abnormal_lipoprotein_level0.79430584
76MP0001849_ear_inflammation0.76061129
77MP0000383_abnormal_hair_follicle0.75210566
78MP0002877_abnormal_melanocyte_morpholog0.74876793
79MP0006082_CNS_inflammation0.74184621
80MP0005332_abnormal_amino_acid0.73730829
81MP0001545_abnormal_hematopoietic_system0.73588185
82MP0005397_hematopoietic_system_phenotyp0.73588185
83* MP0002118_abnormal_lipid_homeostasis0.73489833
84MP0001533_abnormal_skeleton_physiology0.73087376
85MP0004947_skin_inflammation0.70970669
86* MP0005025_abnormal_response_to0.70754787
87MP0003828_pulmonary_edema0.70312236
88MP0002128_abnormal_blood_circulation0.68781909
89MP0009643_abnormal_urine_homeostasis0.68693292
90MP0002925_abnormal_cardiovascular_devel0.68252160
91MP0002168_other_aberrant_phenotype0.67970426
92MP0009764_decreased_sensitivity_to0.67825983
93* MP0001943_abnormal_respiration0.67692906
94* MP0002419_abnormal_innate_immunity0.67359959
95MP0001346_abnormal_lacrimal_gland0.66879718
96MP0010352_gastrointestinal_tract_polyps0.66583439
97MP0003656_abnormal_erythrocyte_physiolo0.66098951
98MP0003436_decreased_susceptibility_to0.65779673
99MP0000685_abnormal_immune_system0.64976167
100MP0009384_cardiac_valve_regurgitation0.64867877
101MP0005165_increased_susceptibility_to0.64795547
102MP0008438_abnormal_cutaneous_collagen0.64553636
103MP0005248_abnormal_Harderian_gland0.64079449
104MP0001614_abnormal_blood_vessel0.63158452
105MP0004264_abnormal_extraembryonic_tissu0.62901626
106MP0002136_abnormal_kidney_physiology0.62739740
107MP0002282_abnormal_trachea_morphology0.61828498
108MP0001501_abnormal_sleep_pattern0.60817183
109MP0000013_abnormal_adipose_tissue0.60466492
110MP0001661_extended_life_span0.60105075
111MP0003638_abnormal_response/metabolism_0.59913695
112MP0000681_abnormal_thyroid_gland0.58607257
113MP0002166_altered_tumor_susceptibility0.58121206
114MP0005647_abnormal_sex_gland0.57648584
115MP0004130_abnormal_muscle_cell0.57478982
116MP0005387_immune_system_phenotype0.57238463
117MP0001790_abnormal_immune_system0.57238463
118MP0002733_abnormal_thermal_nociception0.55384818
119MP0002332_abnormal_exercise_endurance0.55190101
120MP0004484_altered_response_of0.55060247
121MP0002135_abnormal_kidney_morphology0.55016669
122MP0003329_amyloid_beta_deposits0.53886946
123MP0001765_abnormal_ion_homeostasis0.53667490
124MP0002933_joint_inflammation0.53285672
125MP0001986_abnormal_taste_sensitivity0.53102021
126MP0000470_abnormal_stomach_morphology0.52402997
127MP0010155_abnormal_intestine_physiology0.51167756
128MP0010030_abnormal_orbit_morphology0.51080087
129MP0001853_heart_inflammation0.50595405
130MP0003795_abnormal_bone_structure0.49390730
131MP0004085_abnormal_heartbeat0.48110644
132MP0005076_abnormal_cell_differentiation0.45762859

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)6.70013309
2Tubulointerstitial fibrosis (HP:0005576)6.60669716
3Tachypnea (HP:0002789)6.00223091
4Chronic bronchitis (HP:0004469)5.90836485
5Renal salt wasting (HP:0000127)5.73581524
6Respiratory distress (HP:0002098)5.40349089
7Gout (HP:0001997)5.36306662
8Abnormality of the fingertips (HP:0001211)5.30036226
9Systemic lupus erythematosus (HP:0002725)5.29836315
10Polycythemia (HP:0001901)4.97230788
11Glomerulonephritis (HP:0000099)4.66004828
12Alveolar cell carcinoma (HP:0006519)4.46791930
13Onycholysis (HP:0001806)4.43080232
14Hematochezia (HP:0002573)4.34543267
15Complement deficiency (HP:0004431)4.24210917
16Neoplasm of the tracheobronchial system (HP:0100552)4.15090380
17Neurofibrillary tangles (HP:0002185)4.08249818
18Abnormality of the nasal mucosa (HP:0000433)4.07789363
19Hyperkalemia (HP:0002153)4.03668751
20Tubulointerstitial nephritis (HP:0001970)3.81982796
21Ulnar bowing (HP:0003031)3.77106348
22Tubulointerstitial abnormality (HP:0001969)3.76838611
23Exertional dyspnea (HP:0002875)3.63555152
24Abnormality of complement system (HP:0005339)3.58908385
25Spontaneous hematomas (HP:0007420)3.47052844
26Visceral angiomatosis (HP:0100761)3.40289662
27Cerebral inclusion bodies (HP:0100314)3.29257426
28Hemangiomatosis (HP:0007461)3.17341697
29Pulmonary fibrosis (HP:0002206)3.12129735
30Hyperaldosteronism (HP:0000859)3.10409721
31Hypotension (HP:0002615)3.07024608
32Esophageal varix (HP:0002040)3.05153347
33Bronchitis (HP:0012387)2.95741643
34Tubular atrophy (HP:0000092)2.95103146
35Chronic otitis media (HP:0000389)2.89311184
36Abnormality of chloride homeostasis (HP:0011422)2.86284738
37Long toe (HP:0010511)2.84926253
38Broad metatarsal (HP:0001783)2.81135622
39Bowed forearm bones (HP:0003956)2.71440211
40Bowing of the arm (HP:0006488)2.71440211
41Abnormality of renin-angiotensin system (HP:0000847)2.70327362
42Hypergammaglobulinemia (HP:0010702)2.68767093
43Bronchomalacia (HP:0002780)2.68488633
44Thyroid-stimulating hormone excess (HP:0002925)2.67650795
45Cerebral aneurysm (HP:0004944)2.65647803
46Fragile nails (HP:0001808)2.61759218
47Loss of speech (HP:0002371)2.55539367
48Glomerulosclerosis (HP:0000096)2.54668410
49Supranuclear gaze palsy (HP:0000605)2.48329113
50Abnormality of the fetal cardiovascular system (HP:0010948)2.46774559
51Abnormal umbilical cord blood vessels (HP:0011403)2.46774559
52Single umbilical artery (HP:0001195)2.46774559
53Decreased circulating renin level (HP:0003351)2.43528667
54Milia (HP:0001056)2.37742495
55Atrophic scars (HP:0001075)2.37634373
56Osteolytic defects of the phalanges of the hand (HP:0009771)2.36429233
57Osteolytic defects of the hand bones (HP:0009699)2.36429233
58Facial shape deformation (HP:0011334)2.35864048
59Potter facies (HP:0002009)2.35864048
60Neonatal respiratory distress (HP:0002643)2.35495786
61Neoplasm of the lung (HP:0100526)2.34962236
62Increased purine levels (HP:0004368)2.32003650
63Hyperuricemia (HP:0002149)2.32003650
64Subacute progressive viral hepatitis (HP:0006572)2.29917806
65Segmental peripheral demyelination/remyelination (HP:0003481)2.28545499
66Stomach cancer (HP:0012126)2.27847844
67Synostosis involving the elbow (HP:0003938)2.27282178
68Humeroradial synostosis (HP:0003041)2.27282178
69Conjunctival telangiectasia (HP:0000524)2.21505501
70Pulmonary hypertension (HP:0002092)2.20630884
71Hyponatremia (HP:0002902)2.20619275
72Restrictive lung disease (HP:0002091)2.16402805
73Growth hormone excess (HP:0000845)2.15105711
74Stenosis of the external auditory canal (HP:0000402)2.11767412
75Cerebral hemorrhage (HP:0001342)2.11478222
76Pustule (HP:0200039)2.11423239
77Ulnar claw (HP:0001178)2.06038779
78Deep venous thrombosis (HP:0002625)2.06010844
79Abnormality of the vasculature of the conjunctiva (HP:0008054)2.06007463
80Rapidly progressive (HP:0003678)2.02918392
81Abnormality of purine metabolism (HP:0004352)2.02896900
82Interstitial pulmonary disease (HP:0006530)13.7928440
83Neoplasm of the respiratory system (HP:0100606)1.99577701
84Camptodactyly of toe (HP:0001836)1.97575124
85Right ventricular cardiomyopathy (HP:0011663)1.97508216
86Hyperpituitarism (HP:0010514)1.95359872
87Increased CSF protein (HP:0002922)1.92441429
88Megalencephaly (HP:0001355)1.90755474
89Distal lower limb muscle weakness (HP:0009053)1.89390428
90Hypokalemic alkalosis (HP:0001949)1.89140361
91Bronchiectasis (HP:0002110)1.88160773
92Abnormality of macrophages (HP:0004311)1.86800440
93Arterial tortuosity (HP:0005116)1.84714821
94Pulmonary artery stenosis (HP:0004415)1.82905718
95Shallow orbits (HP:0000586)1.82622807
96Glucose intolerance (HP:0000833)1.82299555
97Nasal polyposis (HP:0100582)1.82061306
98Vascular tortuosity (HP:0004948)1.81025122
99Adrenal overactivity (HP:0002717)1.80481634
100Aplasia involving bones of the upper limbs (HP:0009823)1.80144826
101Aplasia of the phalanges of the hand (HP:0009802)1.80144826
102Aplasia involving bones of the extremities (HP:0009825)1.80144826
103Striae distensae (HP:0001065)1.80122934
104Microcytic anemia (HP:0001935)1.79378023
105Plantar hyperkeratosis (HP:0007556)1.78954421
106Joint swelling (HP:0001386)1.78522885
107Abnormality of sodium homeostasis (HP:0010931)1.75750175
108Cavernous hemangioma (HP:0001048)1.75637970
109Recurrent abscess formation (HP:0002722)1.75566522
110Rectal prolapse (HP:0002035)1.72956459
111Purpura (HP:0000979)1.72777608
112Eczematoid dermatitis (HP:0000976)1.72547948
113Myocardial infarction (HP:0001658)1.71322137
114Split foot (HP:0001839)1.69791679
115Turricephaly (HP:0000262)1.69551251
116Micronodular cirrhosis (HP:0001413)1.69381309
117Urinary glycosaminoglycan excretion (HP:0003541)1.69245624
118Mucopolysacchariduria (HP:0008155)1.69245624
119Abnormality of glycolipid metabolism (HP:0010969)1.67553757
120Abnormality of liposaccharide metabolism (HP:0010968)1.67553757
121Abnormality of glycosphingolipid metabolism (HP:0004343)1.67553757
122Abnormal hemoglobin (HP:0011902)1.64611687
123Aortic aneurysm (HP:0004942)1.64372208
124Abnormality of the gastric mucosa (HP:0004295)1.63784977
125Hypoplasia of dental enamel (HP:0006297)1.63741597
126Skin nodule (HP:0200036)1.62407788
127Dysostosis multiplex (HP:0000943)1.62031258
128Annular pancreas (HP:0001734)1.59650355
129Seborrheic dermatitis (HP:0001051)1.58947580
130Mildly elevated creatine phosphokinase (HP:0008180)1.57806461
131Abnormality of polysaccharide metabolism (HP:0011012)1.57652177
132Abnormality of glycosaminoglycan metabolism (HP:0004371)1.57652177
133Abnormality of mucopolysaccharide metabolism (HP:0011020)1.57652177
134Nephritis (HP:0000123)1.57569358
135Recurrent gram-negative bacterial infections (HP:0005420)1.57008405
136Buphthalmos (HP:0000557)1.55686313
137Increased cerebral lipofuscin (HP:0011813)1.53281882
138Joint contractures involving the joints of the feet (HP:0100492)1.51044989
139Flexion contracture of toe (HP:0005830)1.51044989
140Wormian bones (HP:0002645)1.50322312
141Malnutrition (HP:0004395)1.50235184
142Aortic dissection (HP:0002647)1.49346745
143Abnormality of monocarboxylic acid metabolism (HP:0010996)1.47459768
144Mitral stenosis (HP:0001718)1.47136446
145Aneurysm (HP:0002617)1.47027120
146Steatorrhea (HP:0002570)1.45879868
147Prostate neoplasm (HP:0100787)1.42176095
148Dilatation of the ascending aorta (HP:0005111)1.40687938
149Difficulty walking (HP:0002355)1.38019488
150Mucosal telangiectasiae (HP:0100579)1.37276977
151Abnormality of the periventricular white matter (HP:0002518)1.36706452
152Abnormal glucose tolerance (HP:0001952)1.35636228
153Chondrocalcinosis (HP:0000934)1.34904531
154Atrioventricular block (HP:0001678)1.33437027

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.98677217
2FGFR24.05945637
3STK243.63477532
4TGFBR23.58047260
5LRRK23.31381674
6EPHA23.11789367
7ZAP702.81895496
8TRIB32.71496225
9EPHB12.59755147
10MST42.45509120
11PAK42.35795931
12RIPK12.34354341
13EPHB22.30450679
14FER2.09795217
15DAPK22.07737091
16PDGFRB1.97800159
17FGFR41.92061544
18MAP3K21.88996743
19ILK1.83127991
20ERN11.81824381
21CDC42BPA1.74305429
22MST1R1.70798749
23STK101.67067935
24MAP3K61.66501060
25PTK61.62441810
26NLK1.60912617
27PRPF4B1.59402355
28MAP3K31.57012206
29GRK11.56980837
30LMTK21.56461528
31EPHA31.50265660
32MAPK151.43798286
33MYLK1.33296107
34PDGFRA1.21537799
35MAP3K141.17103600
36MET1.14062344
37KSR21.13182271
38CAMK1D1.13088410
39FGFR31.12800092
40MAP3K91.12538305
41IRAK11.11127918
42TESK11.10631110
43CDK61.09914139
44STK38L1.07819504
45PDK21.05837253
46MAP3K131.05590916
47LATS11.02327561
48MAPK71.00186030
49NTRK30.99183096
50MAPK120.98586776
51LATS20.97387827
52PTK20.96018875
53GSK3A0.95568732
54TAOK30.95483794
55PKN20.93870524
56CSK0.93732142
57SIK10.93638409
58TGFBR10.88497546
59EGFR0.86921846
60MAP2K20.83518581
61PRKD10.83167826
62MAP3K120.81121108
63YES10.79187773
64MAP2K30.78134387
65SGK20.78066569
66NEK90.77372916
67KDR0.77344248
68MAPKAPK30.77245379
69RPS6KC10.72553858
70RPS6KL10.72553858
71MAP3K10.71267281
72CAMK1G0.64296464
73STK380.64145724
74DDR20.63401282
75SGK30.63028931
76NEK60.62329286
77MATK0.60887205
78ERBB20.60758587
79SGK4940.60705303
80SGK2230.60705303
81MAP2K10.60645103
82KIT0.60534604
83AKT30.59445090
84LIMK10.58312983
85NTRK10.57348375
86RPS6KA60.56912236
87PDK10.55821340
88PDPK10.54756698
89INSR0.53312111
90FGFR10.53201038
91DAPK30.52470187
92PRKG20.52078761
93TBK10.52034591
94JAK10.49766807
95PTK2B0.49293383
96BMX0.47770431
97MAPKAPK20.46217600
98GRK50.45797277
99RET0.45726226
100GRK70.45641372
101FES0.44954475
102TYK20.44854401
103TTN0.44441881
104MAPK40.43231401
105DAPK10.42297916
106TYRO30.41272787
107ABL10.39643493
108TEC0.39040336
109PRKCQ0.38051058
110MAPK30.38047759
111HIPK20.37885427
112RPS6KA40.37628214
113EEF2K0.37112766
114MAP3K70.37029444
115STK30.36656951
116MTOR0.36589590
117NME10.35367160
118FRK0.32882831
119RIPK40.32663188
120IGF1R0.32427076
121PRKCH0.32282383
122ROCK20.31984670
123DMPK0.31851845
124MARK20.31445524
125CAMKK10.31391810
126IKBKE0.31208245
127FGR0.31104462
128RPS6KA50.29907934
129CHUK0.28193170
130SRC0.27904921
131STK390.27834738
132TRPM70.27635481
133JAK20.27618304
134BLK0.27031968
135FYN0.24689810
136PRKCD0.23025061
137PRKCE0.22835765
138RPS6KA20.21282396
139DYRK1B0.20353167
140ROCK10.20189678

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002323.27804458
2Mineral absorption_Homo sapiens_hsa049783.04447839
3Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.97815718
4Fatty acid biosynthesis_Homo sapiens_hsa000612.79227438
5Asthma_Homo sapiens_hsa053102.76355098
6ECM-receptor interaction_Homo sapiens_hsa045122.44503453
7Allograft rejection_Homo sapiens_hsa053302.38414310
8Graft-versus-host disease_Homo sapiens_hsa053322.34290376
9Autoimmune thyroid disease_Homo sapiens_hsa053202.28503034
10Adherens junction_Homo sapiens_hsa045202.18350361
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10479606
12Lysosome_Homo sapiens_hsa041422.07953311
13Leukocyte transendothelial migration_Homo sapiens_hsa046702.02904172
14Tight junction_Homo sapiens_hsa045301.92493918
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.90899730
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.88209465
17Type I diabetes mellitus_Homo sapiens_hsa049401.86687902
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.75684704
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.73370188
20Pertussis_Homo sapiens_hsa051331.66085855
21Focal adhesion_Homo sapiens_hsa045101.61104067
22Other glycan degradation_Homo sapiens_hsa005111.60057638
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.58536049
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.57240945
25Bladder cancer_Homo sapiens_hsa052191.50234410
26Antigen processing and presentation_Homo sapiens_hsa046121.40581224
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.40529392
28Histidine metabolism_Homo sapiens_hsa003401.38744984
29Malaria_Homo sapiens_hsa051441.32595523
30Hippo signaling pathway_Homo sapiens_hsa043901.31312700
31Amoebiasis_Homo sapiens_hsa051461.29126239
32Chemical carcinogenesis_Homo sapiens_hsa052041.27082173
33Renin-angiotensin system_Homo sapiens_hsa046141.27015646
34Small cell lung cancer_Homo sapiens_hsa052221.26196947
35Glutathione metabolism_Homo sapiens_hsa004801.16883700
36Renal cell carcinoma_Homo sapiens_hsa052111.16032140
37* Phagosome_Homo sapiens_hsa041451.15045726
38Vibrio cholerae infection_Homo sapiens_hsa051101.10511508
39Toxoplasmosis_Homo sapiens_hsa051451.09231965
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.09015970
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07833106
42Fatty acid elongation_Homo sapiens_hsa000621.07817247
43Proteoglycans in cancer_Homo sapiens_hsa052051.06616337
44VEGF signaling pathway_Homo sapiens_hsa043701.05753983
45Fatty acid degradation_Homo sapiens_hsa000711.03968216
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02717982
47Rap1 signaling pathway_Homo sapiens_hsa040151.02526117
48Platelet activation_Homo sapiens_hsa046111.01425945
49Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98032758
50Endocytosis_Homo sapiens_hsa041440.96861998
51Circadian rhythm_Homo sapiens_hsa047100.95925240
52Thyroid cancer_Homo sapiens_hsa052160.94797741
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94568054
54Rheumatoid arthritis_Homo sapiens_hsa053230.94230390
55Complement and coagulation cascades_Homo sapiens_hsa046100.92780430
56Gastric acid secretion_Homo sapiens_hsa049710.92209771
57Pancreatic cancer_Homo sapiens_hsa052120.89925564
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88263259
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87985326
60Tryptophan metabolism_Homo sapiens_hsa003800.87046826
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85866728
62Salmonella infection_Homo sapiens_hsa051320.85639136
63ABC transporters_Homo sapiens_hsa020100.85416492
64TGF-beta signaling pathway_Homo sapiens_hsa043500.85246202
65Hepatitis C_Homo sapiens_hsa051600.83944281
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83573528
67Renin secretion_Homo sapiens_hsa049240.83525144
68Salivary secretion_Homo sapiens_hsa049700.78552870
69Endometrial cancer_Homo sapiens_hsa052130.78360649
70Axon guidance_Homo sapiens_hsa043600.78195767
71Influenza A_Homo sapiens_hsa051640.77224627
72Fatty acid metabolism_Homo sapiens_hsa012120.76243697
73Selenocompound metabolism_Homo sapiens_hsa004500.76138785
74Ether lipid metabolism_Homo sapiens_hsa005650.75765881
75Protein digestion and absorption_Homo sapiens_hsa049740.75736474
76Hematopoietic cell lineage_Homo sapiens_hsa046400.74349451
77Viral myocarditis_Homo sapiens_hsa054160.73143588
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.71532301
79Arachidonic acid metabolism_Homo sapiens_hsa005900.70337835
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.70118476
81Bile secretion_Homo sapiens_hsa049760.68669921
82Pathways in cancer_Homo sapiens_hsa052000.67943180
83Taste transduction_Homo sapiens_hsa047420.67815707
84Dorso-ventral axis formation_Homo sapiens_hsa043200.67304142
85Chronic myeloid leukemia_Homo sapiens_hsa052200.64755199
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63361971
87Starch and sucrose metabolism_Homo sapiens_hsa005000.61508801
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61119381
89Prion diseases_Homo sapiens_hsa050200.61077286
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60900999
91Phenylalanine metabolism_Homo sapiens_hsa003600.60860625
92Dilated cardiomyopathy_Homo sapiens_hsa054140.60222262
93TNF signaling pathway_Homo sapiens_hsa046680.60000944
94Ovarian steroidogenesis_Homo sapiens_hsa049130.59938287
95PPAR signaling pathway_Homo sapiens_hsa033200.59420714
96Shigellosis_Homo sapiens_hsa051310.58648698
97Thyroid hormone synthesis_Homo sapiens_hsa049180.58560819
98Staphylococcus aureus infection_Homo sapiens_hsa051500.58170055
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.57520198
100Acute myeloid leukemia_Homo sapiens_hsa052210.57183519
101Prolactin signaling pathway_Homo sapiens_hsa049170.55975785
102Tyrosine metabolism_Homo sapiens_hsa003500.55658185
103GnRH signaling pathway_Homo sapiens_hsa049120.55087458
104Linoleic acid metabolism_Homo sapiens_hsa005910.54559756
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53816060
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52755778
107Collecting duct acid secretion_Homo sapiens_hsa049660.52698270
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.52397066
109Retinol metabolism_Homo sapiens_hsa008300.51508979
110beta-Alanine metabolism_Homo sapiens_hsa004100.50959696
111Apoptosis_Homo sapiens_hsa042100.49814084
112Leishmaniasis_Homo sapiens_hsa051400.49529766
113Choline metabolism in cancer_Homo sapiens_hsa052310.48315855
114Sphingolipid metabolism_Homo sapiens_hsa006000.48232115
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47797449
116Systemic lupus erythematosus_Homo sapiens_hsa053220.46439717
117Tuberculosis_Homo sapiens_hsa051520.44944574
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44437196
119Notch signaling pathway_Homo sapiens_hsa043300.43332432
120Colorectal cancer_Homo sapiens_hsa052100.43264573
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42866375
122Insulin resistance_Homo sapiens_hsa049310.42834648
123Pancreatic secretion_Homo sapiens_hsa049720.42822272
124Herpes simplex infection_Homo sapiens_hsa051680.42597233
125Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42083034
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.41721331
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.40966334
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39815542
129MAPK signaling pathway_Homo sapiens_hsa040100.39410608
130Melanoma_Homo sapiens_hsa052180.39318535
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37766483
132Estrogen signaling pathway_Homo sapiens_hsa049150.37413800
133Osteoclast differentiation_Homo sapiens_hsa043800.36960857
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36820082
135MicroRNAs in cancer_Homo sapiens_hsa052060.34920667
136Chemokine signaling pathway_Homo sapiens_hsa040620.34085645
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32547769
138Serotonergic synapse_Homo sapiens_hsa047260.32458067

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »