SFXN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.34641050
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.34641050
3L-phenylalanine metabolic process (GO:0006558)6.99565461
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.99565461
5aromatic amino acid family catabolic process (GO:0009074)6.61697780
6tryptophan catabolic process (GO:0006569)5.97929977
7indole-containing compound catabolic process (GO:0042436)5.97929977
8indolalkylamine catabolic process (GO:0046218)5.97929977
9tryptophan metabolic process (GO:0006568)5.78068606
10kynurenine metabolic process (GO:0070189)5.34193765
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.29916207
12glyoxylate metabolic process (GO:0046487)5.23269125
13bile acid biosynthetic process (GO:0006699)5.14585671
14aromatic amino acid family metabolic process (GO:0009072)4.91571901
15high-density lipoprotein particle remodeling (GO:0034375)4.89241468
16homocysteine metabolic process (GO:0050667)4.88590582
17urea cycle (GO:0000050)4.87268427
18urea metabolic process (GO:0019627)4.87268427
19sulfur amino acid catabolic process (GO:0000098)4.85380660
20behavioral response to nicotine (GO:0035095)4.77703082
21serine family amino acid catabolic process (GO:0009071)4.76341511
22peptidyl-glutamic acid carboxylation (GO:0017187)4.74537935
23protein carboxylation (GO:0018214)4.74537935
24regulation of fibrinolysis (GO:0051917)4.72066021
25cysteine metabolic process (GO:0006534)4.70269539
26tyrosine metabolic process (GO:0006570)4.58157846
27nitrogen cycle metabolic process (GO:0071941)4.57686721
28negative regulation of fibrinolysis (GO:0051918)4.57226958
29indolalkylamine metabolic process (GO:0006586)4.56010146
30regulation of cholesterol esterification (GO:0010872)4.55030106
31bile acid metabolic process (GO:0008206)4.52948456
32cellular biogenic amine catabolic process (GO:0042402)4.39907952
33amine catabolic process (GO:0009310)4.39907952
34complement activation, alternative pathway (GO:0006957)4.38185009
35reverse cholesterol transport (GO:0043691)4.35950863
36plasma lipoprotein particle remodeling (GO:0034369)4.32412395
37protein-lipid complex remodeling (GO:0034368)4.32412395
38macromolecular complex remodeling (GO:0034367)4.32412395
39regulation of protein activation cascade (GO:2000257)4.30592320
40alpha-amino acid catabolic process (GO:1901606)4.30394904
41amino-acid betaine metabolic process (GO:0006577)4.27952497
42triglyceride homeostasis (GO:0070328)4.27945991
43acylglycerol homeostasis (GO:0055090)4.27945991
44phospholipid efflux (GO:0033700)4.26975037
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.22077188
46alpha-linolenic acid metabolic process (GO:0036109)4.21320452
47imidazole-containing compound metabolic process (GO:0052803)4.19333191
48intestinal cholesterol absorption (GO:0030299)4.11402903
49cellular modified amino acid catabolic process (GO:0042219)4.07334559
50cellular amino acid catabolic process (GO:0009063)3.97583545
51regulation of complement activation (GO:0030449)3.95682236
52glycine metabolic process (GO:0006544)3.94824461
53regulation of triglyceride catabolic process (GO:0010896)3.94358660
54bile acid and bile salt transport (GO:0015721)3.89756746
55low-density lipoprotein particle remodeling (GO:0034374)3.89453469
56coenzyme catabolic process (GO:0009109)3.85520781
57blood coagulation, intrinsic pathway (GO:0007597)3.84980074
58DNA deamination (GO:0045006)3.84449540
59aldehyde catabolic process (GO:0046185)3.80990754
60serine family amino acid metabolic process (GO:0009069)3.77995202
61cellular glucuronidation (GO:0052695)3.77437503
62negative regulation of cholesterol transport (GO:0032375)3.76800238
63negative regulation of sterol transport (GO:0032372)3.76800238
64fucose catabolic process (GO:0019317)3.76537873
65L-fucose metabolic process (GO:0042354)3.76537873
66L-fucose catabolic process (GO:0042355)3.76537873
67benzene-containing compound metabolic process (GO:0042537)3.75061017
68lysine catabolic process (GO:0006554)3.71182323
69lysine metabolic process (GO:0006553)3.71182323
70meiotic chromosome segregation (GO:0045132)3.70509343
71cholesterol efflux (GO:0033344)3.70172140
72replication fork processing (GO:0031297)3.67923041
73NAD biosynthetic process (GO:0009435)3.67604745
74cellular ketone body metabolic process (GO:0046950)3.65723826
75regulation of nuclear cell cycle DNA replication (GO:0033262)3.61999516
76serine family amino acid biosynthetic process (GO:0009070)3.61777647
77plasma lipoprotein particle assembly (GO:0034377)3.61427387
78water-soluble vitamin biosynthetic process (GO:0042364)3.59383907
79respiratory chain complex IV assembly (GO:0008535)3.55359487
80valine metabolic process (GO:0006573)3.54698189
81drug catabolic process (GO:0042737)3.53996713
82plasma lipoprotein particle clearance (GO:0034381)3.53943321
83organic acid catabolic process (GO:0016054)3.53131582
84carboxylic acid catabolic process (GO:0046395)3.53131582
85recombinational repair (GO:0000725)3.51511209
86double-strand break repair via homologous recombination (GO:0000724)3.51487759
87glucuronate metabolic process (GO:0019585)3.45790530
88uronic acid metabolic process (GO:0006063)3.45790530
89very-low-density lipoprotein particle assembly (GO:0034379)3.45713604
90regulation of bile acid biosynthetic process (GO:0070857)3.45287005
91urate metabolic process (GO:0046415)3.44166245
92drug transmembrane transport (GO:0006855)3.43812198
93detection of light stimulus involved in sensory perception (GO:0050962)3.43102971
94detection of light stimulus involved in visual perception (GO:0050908)3.43102971
95pseudouridine synthesis (GO:0001522)3.42916276
96plasma lipoprotein particle organization (GO:0071827)3.42576400
97response to pheromone (GO:0019236)3.41202812
98peptidyl-histidine modification (GO:0018202)3.38911066
99reciprocal DNA recombination (GO:0035825)3.38888182
100reciprocal meiotic recombination (GO:0007131)3.38888182
101negative regulation of lipase activity (GO:0060192)3.36455863
102nicotinamide nucleotide biosynthetic process (GO:0019359)3.36141769
103pyridine nucleotide biosynthetic process (GO:0019363)3.36141769
104cofactor catabolic process (GO:0051187)3.34115164
105fibrinolysis (GO:0042730)3.33887854
106preassembly of GPI anchor in ER membrane (GO:0016254)3.32667408
107branched-chain amino acid catabolic process (GO:0009083)3.31562873
108neural tube formation (GO:0001841)3.30629194
109lipoprotein metabolic process (GO:0042157)3.30191857
110short-chain fatty acid metabolic process (GO:0046459)3.26905197
111protein activation cascade (GO:0072376)3.25558629
112glutamate metabolic process (GO:0006536)3.25502463
113positive regulation of lipoprotein lipase activity (GO:0051006)3.22959029
114positive regulation of triglyceride lipase activity (GO:0061365)3.22959029
115cholesterol homeostasis (GO:0042632)3.22920482
116L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.22385858
117arginine metabolic process (GO:0006525)3.21850030
118cellular response to ATP (GO:0071318)3.20937053
119carnitine metabolic process (GO:0009437)3.20666499
120detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.18443041
121branched-chain amino acid metabolic process (GO:0009081)3.18153853
122DNA double-strand break processing (GO:0000729)3.17859476
123sterol homeostasis (GO:0055092)3.17681042
124regulation of hippo signaling (GO:0035330)3.16525610
125pyrimidine nucleoside catabolic process (GO:0046135)3.14511535
126ketone body metabolic process (GO:1902224)3.14282289
127cytochrome complex assembly (GO:0017004)3.12870310
128somatic hypermutation of immunoglobulin genes (GO:0016446)3.10138384
129somatic diversification of immune receptors via somatic mutation (GO:0002566)3.10138384
130negative regulation of DNA-dependent DNA replication (GO:2000104)3.09646613
131DNA replication checkpoint (GO:0000076)3.06146811
132NADH dehydrogenase complex assembly (GO:0010257)3.00140246
133mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.00140246
134mitochondrial respiratory chain complex I assembly (GO:0032981)3.00140246
135protein complex biogenesis (GO:0070271)2.98211366
136mannosylation (GO:0097502)2.93683862
137L-methionine salvage (GO:0071267)2.92636426
138L-methionine biosynthetic process (GO:0071265)2.92636426
139amino acid salvage (GO:0043102)2.92636426
140RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.92476500
141maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.92324216
142tRNA modification (GO:0006400)2.92048092
143mitochondrial respiratory chain complex assembly (GO:0033108)2.90636817
144oxidative demethylation (GO:0070989)2.86725569
145rRNA modification (GO:0000154)2.85188756
146DNA strand renaturation (GO:0000733)2.84756282
147methionine biosynthetic process (GO:0009086)2.84571544
148rRNA catabolic process (GO:0016075)2.77659531
149protein K11-linked deubiquitination (GO:0035871)2.74320325
150piRNA metabolic process (GO:0034587)2.73924481
151negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.73905617
152negative regulation of translation, ncRNA-mediated (GO:0040033)2.73905617
153regulation of translation, ncRNA-mediated (GO:0045974)2.73905617
154base-excision repair, AP site formation (GO:0006285)2.73706014
155indole-containing compound metabolic process (GO:0042430)2.73136538
156rRNA methylation (GO:0031167)2.72542583
157sulfation (GO:0051923)2.70668182
158tRNA processing (GO:0008033)2.69039366
159ubiquinone biosynthetic process (GO:0006744)2.67924274
160cornea development in camera-type eye (GO:0061303)2.64735799
161DNA methylation involved in gamete generation (GO:0043046)2.64048275
162axoneme assembly (GO:0035082)2.62802592
163nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.62411629
164exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.58564189
1653-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.58426319
166purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.58426319
167DNA recombination (GO:0006310)2.56337945
168negative regulation of telomere maintenance (GO:0032205)2.55866921
169DNA replication-dependent nucleosome assembly (GO:0006335)2.54888191
170DNA replication-dependent nucleosome organization (GO:0034723)2.54888191
171signal peptide processing (GO:0006465)2.53642899
172synapsis (GO:0007129)2.50129184
173S-adenosylmethionine metabolic process (GO:0046500)2.48751153
174regulation of gene silencing by RNA (GO:0060966)2.47207174
175regulation of posttranscriptional gene silencing (GO:0060147)2.47207174
176regulation of gene silencing by miRNA (GO:0060964)2.47207174
177protein K6-linked ubiquitination (GO:0085020)2.45777993
178DNA demethylation (GO:0080111)2.45372633
179photoreceptor cell maintenance (GO:0045494)2.44346143
180ubiquinone metabolic process (GO:0006743)2.43639959
181regulation of DNA endoreduplication (GO:0032875)2.41328765
182photoreceptor cell development (GO:0042461)2.39710792
183mitochondrial RNA metabolic process (GO:0000959)2.39217957
184peristalsis (GO:0030432)2.39212227
185epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.37257683

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.41039296
2EGR1_23403033_ChIP-Seq_LIVER_Mouse7.01807292
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.19726974
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.71632708
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.62534806
6CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.77288483
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.55863387
8ZNF274_21170338_ChIP-Seq_K562_Hela4.10551092
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.38990689
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.14025955
11GATA1_22025678_ChIP-Seq_K562_Human3.01172073
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.86093215
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.75074170
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.68520380
15EWS_26573619_Chip-Seq_HEK293_Human2.58103157
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.56052242
17IGF1R_20145208_ChIP-Seq_DFB_Human2.40417353
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.39561746
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.36972903
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32451664
21FUS_26573619_Chip-Seq_HEK293_Human2.26328080
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.25798212
23GBX2_23144817_ChIP-Seq_PC3_Human2.17358530
24* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.15294334
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05931913
26ER_23166858_ChIP-Seq_MCF-7_Human2.04067507
27ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.1733549
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99633441
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.97246496
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.94657392
31TAF15_26573619_Chip-Seq_HEK293_Human1.94415980
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90978226
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.89639126
34VDR_23849224_ChIP-Seq_CD4+_Human1.86852508
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82519038
36E2F7_22180533_ChIP-Seq_HELA_Human1.82427217
37MYC_18940864_ChIP-ChIP_HL60_Human1.81336227
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77225661
39IRF1_19129219_ChIP-ChIP_H3396_Human1.70147872
40TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.68646437
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.63801966
42P300_19829295_ChIP-Seq_ESCs_Human1.62807046
43* TP53_22573176_ChIP-Seq_HFKS_Human1.60444645
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.59348153
45HTT_18923047_ChIP-ChIP_STHdh_Human1.57199511
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.50389838
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50212944
48FOXP3_21729870_ChIP-Seq_TREG_Human1.46137801
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44092289
50KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.43218748
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41688752
52ELK1_19687146_ChIP-ChIP_HELA_Human1.40931670
53BCAT_22108803_ChIP-Seq_LS180_Human1.39670513
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35399544
55CBP_20019798_ChIP-Seq_JUKART_Human1.35399544
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34774237
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33636956
58STAT3_23295773_ChIP-Seq_U87_Human1.33571060
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33013721
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32737638
61KAP1_22055183_ChIP-Seq_ESCs_Mouse1.32725365
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32636800
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27578453
64HOXB7_26014856_ChIP-Seq_BT474_Human1.27517397
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.25349000
66HNF4A_19822575_ChIP-Seq_HepG2_Human1.24553926
67GATA3_21878914_ChIP-Seq_MCF-7_Human1.24302340
68* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21437277
69* FOXA1_25329375_ChIP-Seq_VCAP_Human1.21437277
70NCOR_22424771_ChIP-Seq_293T_Human1.20591189
71TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19303012
72RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17932066
73SOX2_19829295_ChIP-Seq_ESCs_Human1.17208882
74NANOG_19829295_ChIP-Seq_ESCs_Human1.17208882
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.16803561
76TCF4_23295773_ChIP-Seq_U87_Human1.16726471
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15781000
78IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12185034
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11820653
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11820653
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10872342
82* FOXA2_19822575_ChIP-Seq_HepG2_Human1.10304502
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09365943
84AR_25329375_ChIP-Seq_VCAP_Human1.09355361
85FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09094219
86FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07975762
87KDM5A_27292631_Chip-Seq_BREAST_Human1.07353730
88AR_21572438_ChIP-Seq_LNCaP_Human1.06388890
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05338208
90ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04007899
91* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03878209
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03675252
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03555796
94FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.03367765
95ERA_21632823_ChIP-Seq_H3396_Human1.03292239
96TCF4_22108803_ChIP-Seq_LS180_Human1.02648754
97* AR_20517297_ChIP-Seq_VCAP_Human1.02219455
98GATA4_25053715_ChIP-Seq_YYC3_Human1.02157706
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01489501
100BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01271162
101EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00356747
102CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00300358
103BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00038813
104PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99827805
105NFE2_27457419_Chip-Seq_LIVER_Mouse0.99675905
106POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99135372
107SMAD4_21799915_ChIP-Seq_A2780_Human0.98900570
108ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97929100
109RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97340694
110E2F1_21310950_ChIP-Seq_MCF-7_Human0.94791726
111SMAD3_21741376_ChIP-Seq_EPCs_Human0.94526423
112SMAD4_21741376_ChIP-Seq_EPCs_Human0.93896613
113* RUNX2_22187159_ChIP-Seq_PCA_Human0.92615080
114P53_21459846_ChIP-Seq_SAOS-2_Human0.92014310
115SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91781919
116FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.91563742
117EZH2_27294783_Chip-Seq_NPCs_Mouse0.91542626
118FLI1_21867929_ChIP-Seq_TH2_Mouse0.90040526
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89556834
120BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.88320238
121NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.86995927
122PCGF2_27294783_Chip-Seq_NPCs_Mouse0.85108867
123SOX2_27498859_Chip-Seq_STOMACH_Mouse0.83042791
124BP1_19119308_ChIP-ChIP_Hs578T_Human0.82566058
125RUNX1_27457419_Chip-Seq_LIVER_Mouse0.81363500
126Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80280409
127CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.77775441
128* ESR1_21235772_ChIP-Seq_MCF-7_Human0.77071564
129FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.76013589
130RARA_24833708_ChIP-Seq_LIVER_Mouse0.74215676
131SMAD1_18555785_Chip-Seq_ESCs_Mouse0.73877787
132STAT1_17558387_ChIP-Seq_HELA_Human0.72957744
133JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.72764546
134NOTCH1_21737748_ChIP-Seq_TLL_Human0.71241476
135ESRRB_18555785_Chip-Seq_ESCs_Mouse0.71154646
136IRF8_21731497_ChIP-ChIP_J774_Mouse0.71017995
137CRX_20693478_ChIP-Seq_RETINA_Mouse0.70309063
138E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.69598129
139SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.69591017
140PCGF2_27294783_Chip-Seq_ESCs_Mouse0.69253296
141STAT3_18555785_Chip-Seq_ESCs_Mouse0.68650213
142ZFX_18555785_Chip-Seq_ESCs_Mouse0.67402560
143SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.67385379
144AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67182183
145ERG_20517297_ChIP-Seq_VCAP_Human0.65955048
146PU1_27457419_Chip-Seq_LIVER_Mouse0.65565839
147OCT4_18555785_Chip-Seq_ESCs_Mouse0.65489680
148EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.65451898
149LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.64916572
150NMYC_18555785_Chip-Seq_ESCs_Mouse0.64809865
151CEBPB_22108803_ChIP-Seq_LS180_Human0.64183830
152RARB_24833708_ChIP-Seq_LIVER_Mouse0.62237519
153ESET_19884257_ChIP-Seq_ESCs_Mouse0.61895720
154FLI1_27457419_Chip-Seq_LIVER_Mouse0.60306521
155OCT4_21477851_ChIP-Seq_ESCs_Mouse0.59847309
156SUZ12_18555785_Chip-Seq_ESCs_Mouse0.59476953
157SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.59399190
158P53_22387025_ChIP-Seq_ESCs_Mouse0.58852291
159RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.58091384
160RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.57960181
161EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.57890591
162FOXA1_25552417_ChIP-Seq_VCAP_Human0.57214510
163KLF4_18555785_Chip-Seq_ESCs_Mouse0.57007133
164CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.56474461
165P300_18555785_Chip-Seq_ESCs_Mouse0.55899693
166* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.55213747
167CTCF_18555785_Chip-Seq_ESCs_Mouse0.54749702
168GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.53759695
169HNFA_21074721_ChIP-Seq_CACO-2_Human0.53727030
170PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.53271656
171AUTS2_25519132_ChIP-Seq_293T-REX_Human0.52497477
172GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.51944617
173PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.50779925
174* TAF2_19829295_ChIP-Seq_ESCs_Human0.50773993
175BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.50573146
176VDR_22108803_ChIP-Seq_LS180_Human0.50352483
177IRF8_27001747_Chip-Seq_BMDM_Mouse0.50347191
178ETV2_25802403_ChIP-Seq_MESCs_Mouse0.50092134
179SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.50064063

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.24739283
2MP0005360_urolithiasis6.28195122
3MP0005365_abnormal_bile_salt6.00379530
4MP0005085_abnormal_gallbladder_physiolo5.72380354
5MP0008875_abnormal_xenobiotic_pharmacok4.34076591
6MP0003252_abnormal_bile_duct3.68206982
7MP0003195_calcinosis3.33387459
8MP0003806_abnormal_nucleotide_metabolis3.17373912
9MP0005083_abnormal_biliary_tract3.00412603
10MP0001666_abnormal_nutrient_absorption2.88623039
11MP0010329_abnormal_lipoprotein_level2.88551690
12MP0005332_abnormal_amino_acid2.64528600
13MP0008877_abnormal_DNA_methylation2.61599443
14MP0004019_abnormal_vitamin_homeostasis2.59176453
15MP0002138_abnormal_hepatobiliary_system2.57934194
16MP0003136_yellow_coat_color2.55064919
17MP0005174_abnormal_tail_pigmentation2.44917165
18MP0008057_abnormal_DNA_replication2.42785886
19MP0009840_abnormal_foam_cell2.39565301
20MP0005551_abnormal_eye_electrophysiolog2.36882545
21MP0008058_abnormal_DNA_repair2.31901272
22MP0003868_abnormal_feces_composition2.30080316
23MP0010094_abnormal_chromosome_stability2.28952245
24MP0001968_abnormal_touch/_nociception2.26622993
25MP0002102_abnormal_ear_morphology2.10026677
26MP0000569_abnormal_digit_pigmentation2.07996678
27MP0002736_abnormal_nociception_after2.04229835
28MP0001764_abnormal_homeostasis1.96978580
29MP0003191_abnormal_cellular_cholesterol1.95441987
30MP0005220_abnormal_exocrine_pancreas1.91610457
31MP0008872_abnormal_physiological_respon1.86495098
32MP0005451_abnormal_body_composition1.85814616
33MP0000609_abnormal_liver_physiology1.84456866
34MP0003693_abnormal_embryo_hatching1.81780439
35MP0002118_abnormal_lipid_homeostasis1.81176034
36MP0006072_abnormal_retinal_apoptosis1.72581302
37MP0005646_abnormal_pituitary_gland1.69075448
38MP0002160_abnormal_reproductive_system1.68411400
39MP0005319_abnormal_enzyme/_coenzyme1.67219963
40MP0009697_abnormal_copulation1.60823691
41MP0005253_abnormal_eye_physiology1.60365183
42MP0009643_abnormal_urine_homeostasis1.59147747
43MP0002638_abnormal_pupillary_reflex1.58591609
44MP0004147_increased_porphyrin_level1.57738652
45MP0005084_abnormal_gallbladder_morpholo1.57106844
46MP0005645_abnormal_hypothalamus_physiol1.57059060
47MP0003186_abnormal_redox_activity1.56591014
48MP0002876_abnormal_thyroid_physiology1.53081908
49MP0002837_dystrophic_cardiac_calcinosis1.49268960
50MP0005389_reproductive_system_phenotype1.47936086
51MP0003646_muscle_fatigue1.45575990
52MP0005171_absent_coat_pigmentation1.43274939
53MP0005408_hypopigmentation1.41349260
54MP0000372_irregular_coat_pigmentation1.40140532
55MP0004043_abnormal_pH_regulation1.39587197
56MP0003011_delayed_dark_adaptation1.39359727
57MP0000631_abnormal_neuroendocrine_gland1.38675684
58MP0009046_muscle_twitch1.37508581
59MP0004782_abnormal_surfactant_physiolog1.27704202
60MP0003111_abnormal_nucleus_morphology1.25215741
61MP0003786_premature_aging1.24099317
62MP0001485_abnormal_pinna_reflex1.20905849
63MP0003787_abnormal_imprinting1.20264572
64MP0000383_abnormal_hair_follicle1.19612324
65MP0005636_abnormal_mineral_homeostasis1.17221432
66MP0006276_abnormal_autonomic_nervous1.16785298
67MP0009764_decreased_sensitivity_to1.16546717
68MP0002653_abnormal_ependyma_morphology1.14907157
69MP0000015_abnormal_ear_pigmentation1.13380910
70MP0004142_abnormal_muscle_tone1.12682836
71MP0002693_abnormal_pancreas_physiology1.11852127
72MP0005647_abnormal_sex_gland1.11526718
73MP0005584_abnormal_enzyme/coenzyme_acti1.11473711
74MP0002132_abnormal_respiratory_system1.09287479
75MP0009745_abnormal_behavioral_response1.07398409
76MP0000598_abnormal_liver_morphology1.06467264
77MP0001944_abnormal_pancreas_morphology1.05781016
78MP0008469_abnormal_protein_level1.05644623
79MP0002254_reproductive_system_inflammat1.05496631
80MP0002078_abnormal_glucose_homeostasis1.05483648
81MP0001873_stomach_inflammation1.05451951
82MP0003724_increased_susceptibility_to1.05121857
83MP0002210_abnormal_sex_determination1.04785951
84MP0008995_early_reproductive_senescence1.04192729
85MP0005379_endocrine/exocrine_gland_phen1.04068055
86MP0001929_abnormal_gametogenesis1.02148740
87MP0002928_abnormal_bile_duct1.01981641
88MP0002234_abnormal_pharynx_morphology1.00387979
89MP0002735_abnormal_chemical_nociception0.97960104
90MP0009763_increased_sensitivity_to0.97504282
91MP0001756_abnormal_urination0.97017329
92MP0004133_heterotaxia0.95486864
93MP0003698_abnormal_male_reproductive0.94839835
94MP0002095_abnormal_skin_pigmentation0.94613703
95MP0006035_abnormal_mitochondrial_morpho0.94449082
96MP0009642_abnormal_blood_homeostasis0.94160579
97MP0000516_abnormal_urinary_system0.92946519
98MP0005367_renal/urinary_system_phenotyp0.92946519
99MP0005423_abnormal_somatic_nervous0.92189139
100MP0002751_abnormal_autonomic_nervous0.92145133
101MP0000653_abnormal_sex_gland0.91528265
102MP0005670_abnormal_white_adipose0.90720348
103MP0008007_abnormal_cellular_replicative0.90644184
104MP0005410_abnormal_fertilization0.90367824
105MP0003880_abnormal_central_pattern0.90279899
106MP0000566_synostosis0.89998632
107MP0001145_abnormal_male_reproductive0.89296454
108MP0005075_abnormal_melanosome_morpholog0.86466337
109MP0001188_hyperpigmentation0.86031505
110MP0001501_abnormal_sleep_pattern0.85196662
111MP0008961_abnormal_basal_metabolism0.84815396
112MP0002163_abnormal_gland_morphology0.82503124
113MP0003890_abnormal_embryonic-extraembry0.81749570
114MP0006292_abnormal_olfactory_placode0.81024738
115MP0005195_abnormal_posterior_eye0.80610757
116MP0003943_abnormal_hepatobiliary_system0.80485140
117MP0002272_abnormal_nervous_system0.80281235
118MP0009765_abnormal_xenobiotic_induced0.79943942
119MP0003077_abnormal_cell_cycle0.79301827
120MP0001119_abnormal_female_reproductive0.77999433
121MP0003436_decreased_susceptibility_to0.77221555
122MP0003937_abnormal_limbs/digits/tail_de0.77043008
123MP0005377_hearing/vestibular/ear_phenot0.76649665
124MP0003878_abnormal_ear_physiology0.76649665
125MP0004742_abnormal_vestibular_system0.76073754
126MP0005334_abnormal_fat_pad0.73756294
127MP0006036_abnormal_mitochondrial_physio0.71360792
128MP0001661_extended_life_span0.71021193
129MP0001835_abnormal_antigen_presentation0.69017630
130MP0003656_abnormal_erythrocyte_physiolo0.68227986
131MP0002136_abnormal_kidney_physiology0.67983523
132MP0003953_abnormal_hormone_level0.65169791
133MP0005376_homeostasis/metabolism_phenot0.62197379
134MP0003183_abnormal_peptide_metabolism0.61007373
135MP0000613_abnormal_salivary_gland0.57156684
136MP0001986_abnormal_taste_sensitivity0.57114704
137MP0001845_abnormal_inflammatory_respons0.55175749
138MP0005058_abnormal_lysosome_morphology0.54775668
139MP0005535_abnormal_body_temperature0.54724744
140MP0004381_abnormal_hair_follicle0.54240312
141MP0005464_abnormal_platelet_physiology0.53540111
142MP0009672_abnormal_birth_weight0.52875103
143MP0000678_abnormal_parathyroid_gland0.52846873
144MP0003718_maternal_effect0.52517707
145MP0000371_diluted_coat_color0.50522374
146MP0000639_abnormal_adrenal_gland0.50071274
147MP0000538_abnormal_urinary_bladder0.49816246
148MP0001324_abnormal_eye_pigmentation0.49126546
149MP0006082_CNS_inflammation0.48881491
150MP0000579_abnormal_nail_morphology0.48482667
151MP0005395_other_phenotype0.47730977
152MP0010368_abnormal_lymphatic_system0.47617052
153MP0003638_abnormal_response/metabolism_0.47450599
154MP0004264_abnormal_extraembryonic_tissu0.46271743
155MP0002277_abnormal_respiratory_mucosa0.46127221
156MP0005448_abnormal_energy_balance0.46082566
157MP0002098_abnormal_vibrissa_morphology0.45660188
158MP0010386_abnormal_urinary_bladder0.44151607
159MP0002419_abnormal_innate_immunity0.42823982
160MP0009785_altered_susceptibility_to0.42573297
161MP0005248_abnormal_Harderian_gland0.41878518
162MP0002971_abnormal_brown_adipose0.41729388
163MP0002938_white_spotting0.39427727
164MP0005025_abnormal_response_to0.39373540
165MP0001765_abnormal_ion_homeostasis0.39020554
166MP0003959_abnormal_lean_body0.37760200
167MP0002060_abnormal_skin_morphology0.37237860
168MP0000427_abnormal_hair_cycle0.35571265
169MP0001919_abnormal_reproductive_system0.35283610
170MP0001790_abnormal_immune_system0.34275502

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.01566996
2Prolonged partial thromboplastin time (HP:0003645)6.36210776
3Intrahepatic cholestasis (HP:0001406)5.96415242
4Deep venous thrombosis (HP:0002625)5.40704374
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.38578025
6Joint hemorrhage (HP:0005261)5.12469015
7Xanthomatosis (HP:0000991)4.85194633
8Hypobetalipoproteinemia (HP:0003563)4.69992811
9Hypoglycemic coma (HP:0001325)4.63346650
10Congenital stationary night blindness (HP:0007642)4.44638959
11Abnormality of the intrinsic pathway (HP:0010989)4.34073554
12Ketosis (HP:0001946)4.20463122
13Abnormality of the common coagulation pathway (HP:0010990)4.18228602
14Hyperlipoproteinemia (HP:0010980)4.06354287
15Abnormality of methionine metabolism (HP:0010901)4.00713116
16Pancreatic cysts (HP:0001737)3.97316828
17Abnormality of pyrimidine metabolism (HP:0004353)3.92781914
18Hyperglycinemia (HP:0002154)3.91894033
19Hyperglycinuria (HP:0003108)3.91048452
20Complement deficiency (HP:0004431)3.87787095
21Hypoglycemic seizures (HP:0002173)3.82399585
22Abnormality of aspartate family amino acid metabolism (HP:0010899)3.80827937
23Abnormality of sulfur amino acid metabolism (HP:0004339)3.79250262
24Conjugated hyperbilirubinemia (HP:0002908)3.78440288
25Ketoacidosis (HP:0001993)3.71684004
26Hyperammonemia (HP:0001987)3.68825450
27Abnormality of glutamine family amino acid metabolism (HP:0010902)3.64975537
28Fat malabsorption (HP:0002630)3.64954103
29Epidermoid cyst (HP:0200040)3.61965909
30Hypolipoproteinemia (HP:0010981)3.56393808
31Abnormality of glycine metabolism (HP:0010895)3.56271183
32Abnormality of serine family amino acid metabolism (HP:0010894)3.56271183
33Attenuation of retinal blood vessels (HP:0007843)3.51711077
34Pancreatic fibrosis (HP:0100732)3.40956498
35Hyperinsulinemic hypoglycemia (HP:0000825)3.39753765
36True hermaphroditism (HP:0010459)3.28292383
37Molar tooth sign on MRI (HP:0002419)3.27116139
38Abnormality of midbrain morphology (HP:0002418)3.27116139
39Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.24542991
40Hypoalphalipoproteinemia (HP:0003233)3.16075580
41Abnormality of nucleobase metabolism (HP:0010932)3.15463547
42Nephronophthisis (HP:0000090)3.15198760
43Generalized aminoaciduria (HP:0002909)3.13841956
44Abnormality of fatty-acid metabolism (HP:0004359)3.10635299
45Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.08845944
46Symptomatic seizures (HP:0011145)3.03068169
47Hyperbilirubinemia (HP:0002904)2.99176064
48Enlarged kidneys (HP:0000105)2.91395096
49Renal cortical cysts (HP:0000803)2.87290235
50Abnormality of complement system (HP:0005339)2.86462657
51Abnormality of the renal medulla (HP:0100957)2.86306131
52Steatorrhea (HP:0002570)2.85929110
53Patellar aplasia (HP:0006443)2.82980953
54Pendular nystagmus (HP:0012043)2.81453811
55Hypochromic microcytic anemia (HP:0004840)2.81443253
56Abnormality of purine metabolism (HP:0004352)2.76804364
57Abnormality of serum amino acid levels (HP:0003112)2.75382091
58Chronic hepatic failure (HP:0100626)2.72135272
59Aplasia/Hypoplasia of the patella (HP:0006498)2.71662595
60Hypercholesterolemia (HP:0003124)2.71628421
61Delayed CNS myelination (HP:0002188)2.70253183
62Birth length less than 3rd percentile (HP:0003561)2.67046773
63Tubular atrophy (HP:0000092)2.66958613
64Hepatocellular carcinoma (HP:0001402)2.66096729
65Gout (HP:0001997)2.65564721
66Abnormality of dicarboxylic acid metabolism (HP:0010995)2.62563077
67Dicarboxylic aciduria (HP:0003215)2.62563077
68Aplasia/Hypoplasia of the uvula (HP:0010293)2.60429136
69Chromosomal breakage induced by crosslinking agents (HP:0003221)2.60194209
70Metabolic acidosis (HP:0001942)2.57715593
71Hypoplasia of the pons (HP:0012110)2.57358764
72Hyperventilation (HP:0002883)2.56382039
73Myocardial infarction (HP:0001658)2.54571924
74Hyperglycemia (HP:0003074)2.53868917
75Late onset (HP:0003584)2.52589654
76Menorrhagia (HP:0000132)2.52540341
77Reduced antithrombin III activity (HP:0001976)2.52380650
78Abnormality of the pons (HP:0007361)2.50641762
79Polydipsia (HP:0001959)2.50145351
80Abnormal drinking behavior (HP:0030082)2.50145351
81Lethargy (HP:0001254)2.47009848
82Type II lissencephaly (HP:0007260)2.46211428
83Opisthotonus (HP:0002179)2.45354625
84Glycosuria (HP:0003076)2.44856302
85Abnormality of urine glucose concentration (HP:0011016)2.44856302
86Chromsome breakage (HP:0040012)2.44495000
87Decreased electroretinogram (ERG) amplitude (HP:0000654)2.44105674
88Medial flaring of the eyebrow (HP:0010747)2.43538441
89Gaze-evoked nystagmus (HP:0000640)2.43456459
90Abolished electroretinogram (ERG) (HP:0000550)2.42872215
91Vascular calcification (HP:0004934)2.42105824
92Cystic liver disease (HP:0006706)2.41982791
93Colon cancer (HP:0003003)2.39870594
94Proximal tubulopathy (HP:0000114)2.39632521
95Abnormality of alanine metabolism (HP:0010916)2.38663819
96Hyperalaninemia (HP:0003348)2.38663819
97Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.38663819
98Bony spicule pigmentary retinopathy (HP:0007737)2.37541411
99Pancreatic islet-cell hyperplasia (HP:0004510)2.37308770
100Systemic lupus erythematosus (HP:0002725)2.33985293
101Pancreatitis (HP:0001733)2.32398425
102Stomach cancer (HP:0012126)2.31788584
103Glomerulonephritis (HP:0000099)2.30157247
104Alkalosis (HP:0001948)2.29304439
105Gingival bleeding (HP:0000225)2.29126673
106Abnormality of the ileum (HP:0001549)2.24593152
107Absent thumb (HP:0009777)2.24245844
108Meckel diverticulum (HP:0002245)2.21363816
109Polyuria (HP:0000103)2.20933511
110Methylmalonic aciduria (HP:0012120)2.16360022
111Methylmalonic acidemia (HP:0002912)2.15807844
112Chorioretinal atrophy (HP:0000533)2.14533731
113Recurrent gram-negative bacterial infections (HP:0005420)2.14264366
114Genetic anticipation (HP:0003743)2.14133951
115Irritability (HP:0000737)2.12888747
116Decreased central vision (HP:0007663)2.12561036
117Abnormality of endocrine pancreas physiology (HP:0012093)2.12513775
118Abnormality of the pancreatic islet cells (HP:0006476)2.12513775
119Decreased circulating renin level (HP:0003351)2.10521376
120Abnormal rod and cone electroretinograms (HP:0008323)2.09868936
121Sclerocornea (HP:0000647)2.09792717
122Type I transferrin isoform profile (HP:0003642)2.07955829
123Abnormality of chromosome stability (HP:0003220)2.07123822
124Cerebral edema (HP:0002181)2.06609987
125Cerebellar dysplasia (HP:0007033)2.05442943
126Mitral stenosis (HP:0001718)2.03999599
127Abnormal enzyme/coenzyme activity (HP:0012379)2.03277531
128Cardiovascular calcification (HP:0011915)2.03141843
129Increased CSF lactate (HP:0002490)2.02910866
130Abnormal protein glycosylation (HP:0012346)2.02316762
131Abnormal glycosylation (HP:0012345)2.02316762
132Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.02316762
133Abnormal protein N-linked glycosylation (HP:0012347)2.02316762
134Clubbing of toes (HP:0100760)2.01153565
135Aplasia/Hypoplasia of the tibia (HP:0005772)1.98834783
136Skin nodule (HP:0200036)1.98674535
137Sloping forehead (HP:0000340)1.98669605
138Spontaneous abortion (HP:0005268)1.98660658
139Abnormality of the labia minora (HP:0012880)1.98244514
140Progressive inability to walk (HP:0002505)1.97760181
141Vomiting (HP:0002013)1.95574349
142Rib fusion (HP:0000902)1.94213869
143Abnormality of the preputium (HP:0100587)1.93117520
144Elevated alkaline phosphatase (HP:0003155)1.92641075
145Congenital hepatic fibrosis (HP:0002612)1.92126922
146Inability to walk (HP:0002540)1.89481925
147Aplasia/Hypoplasia of the tongue (HP:0010295)1.89043460
148Protruding tongue (HP:0010808)1.88563177
149Abnormality of alkaline phosphatase activity (HP:0004379)1.88288128
150Concave nail (HP:0001598)1.88073389
151Elevated hepatic transaminases (HP:0002910)1.87889137
152Cerebral palsy (HP:0100021)1.85587781
153Large for gestational age (HP:0001520)1.85381593
154Osteomalacia (HP:0002749)1.85143464
155Lissencephaly (HP:0001339)1.82947048
156Amyloidosis (HP:0011034)1.82632717
157Mitochondrial inheritance (HP:0001427)1.81744306
158Male pseudohermaphroditism (HP:0000037)1.80295980
159Increased purine levels (HP:0004368)1.79508131
160Hyperuricemia (HP:0002149)1.79508131
161Congenital primary aphakia (HP:0007707)1.79315540
162Anencephaly (HP:0002323)1.79150434
163Hepatocellular necrosis (HP:0001404)1.78404751
164Short thumb (HP:0009778)1.78032390
165Aplasia involving forearm bones (HP:0009822)1.77947999
166Absent forearm bone (HP:0003953)1.77947999
167Postaxial foot polydactyly (HP:0001830)1.77766464
168Broad-based gait (HP:0002136)1.77726325
169Abnormality of the renal cortex (HP:0011035)1.76704088
170Furrowed tongue (HP:0000221)1.76519425
171Small hand (HP:0200055)1.76460567
172Abnormality of the renal collecting system (HP:0004742)1.76382469
173Gait imbalance (HP:0002141)1.76219570
174Rickets (HP:0002748)1.75853388
175Absent radius (HP:0003974)1.75509152
176Progressive cerebellar ataxia (HP:0002073)1.75272111
177Increased serum lactate (HP:0002151)1.75111328
178Hepatic necrosis (HP:0002605)1.74133930
179Fair hair (HP:0002286)1.74119661
180Abnormal urine output (HP:0012590)1.73700994
181Ectopic kidney (HP:0000086)1.72001825
182Hydroxyprolinuria (HP:0003080)1.71967530
183Abnormality of proline metabolism (HP:0010907)1.71967530
184Abnormal biliary tract physiology (HP:0012439)1.70715949
185Bile duct proliferation (HP:0001408)1.70715949
186Thrombophlebitis (HP:0004418)1.70038620
187Limb hypertonia (HP:0002509)1.69462204
188Brushfield spots (HP:0001088)1.66554098
189Hypophosphatemic rickets (HP:0004912)1.66077919

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.95617427
2BCKDK4.71276107
3IRAK33.39733069
4ERN13.12593353
5TAOK32.94515716
6MAP3K142.53743795
7SIK12.49225630
8MAPK152.42191420
9TLK12.35029420
10FLT32.19672653
11FGFR42.19434909
12MAP4K22.04898416
13FRK2.04321160
14WNK31.94829241
15PIK3CG1.94824444
16STK161.89529978
17TRIM281.80841795
18STK391.79046743
19OXSR11.75639518
20AKT31.68562794
21MKNK21.63146197
22IRAK41.61119487
23ZAK1.56462252
24VRK21.54924818
25GRK11.54652090
26VRK11.45006664
27MAPK131.41455867
28STK38L1.36987190
29MUSK1.33891040
30SRPK11.33108229
31TYK21.32830691
32EIF2AK21.31032301
33PASK1.22969071
34NEK91.22257944
35BUB11.21836000
36CDC71.18364685
37ERBB41.17277368
38EIF2AK31.13606734
39MAPK111.12477065
40MAPKAPK31.11729941
41NLK1.11709031
42JAK31.11537399
43WEE11.09798607
44MST1R1.09712593
45TAF11.08119842
46TGFBR11.07508598
47NUAK11.03168408
48CASK0.99189407
49TSSK60.98184336
50PLK30.97982690
51ATR0.97674321
52PINK10.97519489
53YES10.97355323
54IKBKE0.96616076
55TXK0.94832208
56IKBKB0.93904314
57MAP3K40.92397797
58CAMKK20.92117926
59EPHA30.92026851
60NME10.91963254
61ADRBK10.91572742
62IRAK10.91394087
63MAP3K30.89293531
64BLK0.89245585
65SGK20.89112533
66JAK10.85967282
67ADRBK20.85683555
68CHEK20.85582832
69TEC0.82249975
70PLK10.81924653
71CHUK0.81852800
72PNCK0.79360594
73PAK30.78992416
74MKNK10.78029366
75TBK10.76619786
76NEK60.76167773
77NEK20.76037926
78WNK40.75403606
79DYRK20.72479753
80DAPK20.71313316
81PTK60.71175861
82ZAP700.69575855
83PLK40.69490420
84FGFR20.69314787
85MST40.68946790
86TNIK0.68303337
87PIK3CA0.67010932
88MAP2K20.66350486
89CSK0.65839727
90CSNK1G10.65678010
91RPS6KA50.65046556
92MAPKAPK50.64348670
93BMPR20.62750379
94DYRK1B0.61190260
95TNK20.60947037
96HIPK20.60701999
97CSNK1G30.59862987
98BTK0.58511582
99CSNK1A1L0.58252540
100PRKCG0.58050516
101LYN0.57577913
102BMPR1B0.57529924
103PRKAA20.57319672
104PRKCE0.57113655
105STK30.56907328
106MAP3K130.56723883
107LATS10.56234965
108CCNB10.55621596
109TGFBR20.54987547
110ATM0.54749203
111JAK20.53402089
112STK40.52629118
113CSNK1G20.52201583
114GSK3A0.51108244
115MAP2K70.50465034
116BRAF0.48641458
117MAPK70.48637976
118SGK30.48531708
119IGF1R0.48411123
120PKN20.48314075
121PBK0.48018003
122IRAK20.47900091
123PRKCI0.47491278
124FGFR30.47340654
125BRSK20.45564549
126CSNK1D0.45166915
127PLK20.44306756
128CAMK1D0.44083440
129ABL20.43929403
130ERBB30.43764026
131MAP4K10.43158011
132ERBB20.42448461
133MAP2K60.41232953
134SGK2230.41150934
135SGK4940.41150934
136CDK60.40233777
137CSNK1A10.39271623
138TTK0.39225721
139ACVR1B0.39020040
140MAPK30.38646518
141MET0.38589653
142PRKCQ0.38257309
143NEK10.37471624
144RPS6KB10.37207078
145CAMK1G0.36871608
146PRKAA10.35981456
147ITK0.35459366
148PRKACG0.34759486
149TIE10.34615849
150MAPK40.34600443
151EIF2AK10.34535157
152CDK40.33639419
153RPS6KB20.31852025
154SYK0.31845736
155CSNK2A10.31648903
156MELK0.31144145
157CDK30.31050739
158FER0.31041648
159CSF1R0.30803020
160CHEK10.28198746
161GRK60.27897667
162PRKACA0.27779160
163STK110.27351080

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.00229624
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.17197082
3Homologous recombination_Homo sapiens_hsa034403.05834399
4Maturity onset diabetes of the young_Homo sapiens_hsa049503.00866642
5Tryptophan metabolism_Homo sapiens_hsa003802.77047584
6Complement and coagulation cascades_Homo sapiens_hsa046102.56400742
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.54745814
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.48066872
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.43971914
10Arginine biosynthesis_Homo sapiens_hsa002202.42846965
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.39685972
12Fatty acid degradation_Homo sapiens_hsa000712.28837213
13RNA polymerase_Homo sapiens_hsa030202.28816628
14Nitrogen metabolism_Homo sapiens_hsa009102.19668407
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.19084565
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.16394629
17Peroxisome_Homo sapiens_hsa041462.13466745
18Histidine metabolism_Homo sapiens_hsa003402.11081092
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10903308
20Phototransduction_Homo sapiens_hsa047442.10355086
21Sulfur metabolism_Homo sapiens_hsa009201.98616378
22Non-homologous end-joining_Homo sapiens_hsa034501.98609230
23Selenocompound metabolism_Homo sapiens_hsa004501.97145871
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.96517190
25Folate biosynthesis_Homo sapiens_hsa007901.91311273
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.89563847
27Butanoate metabolism_Homo sapiens_hsa006501.89228620
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.89008135
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.85459877
30beta-Alanine metabolism_Homo sapiens_hsa004101.84815643
31Chemical carcinogenesis_Homo sapiens_hsa052041.81866431
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.72710919
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.72668608
34Propanoate metabolism_Homo sapiens_hsa006401.71764741
35Retinol metabolism_Homo sapiens_hsa008301.70945286
36Staphylococcus aureus infection_Homo sapiens_hsa051501.70102618
37Phenylalanine metabolism_Homo sapiens_hsa003601.66688945
38Fatty acid metabolism_Homo sapiens_hsa012121.63778186
39Basal transcription factors_Homo sapiens_hsa030221.58975800
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.58083555
41Base excision repair_Homo sapiens_hsa034101.55456251
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.51339445
43ABC transporters_Homo sapiens_hsa020101.47914101
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.47855833
45PPAR signaling pathway_Homo sapiens_hsa033201.47106996
46Starch and sucrose metabolism_Homo sapiens_hsa005001.44329233
47Protein export_Homo sapiens_hsa030601.41567665
48Tyrosine metabolism_Homo sapiens_hsa003501.41159314
49One carbon pool by folate_Homo sapiens_hsa006701.35833631
50Caffeine metabolism_Homo sapiens_hsa002321.34713925
51Fatty acid elongation_Homo sapiens_hsa000621.34261224
52RNA degradation_Homo sapiens_hsa030181.31510007
53Proteasome_Homo sapiens_hsa030501.29184966
54DNA replication_Homo sapiens_hsa030301.28975951
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28245868
56Oxidative phosphorylation_Homo sapiens_hsa001901.27468473
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24568942
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.23202876
59Arginine and proline metabolism_Homo sapiens_hsa003301.20072045
60Vitamin digestion and absorption_Homo sapiens_hsa049771.19793183
61Ether lipid metabolism_Homo sapiens_hsa005651.17943047
62Steroid biosynthesis_Homo sapiens_hsa001001.15614315
63Mismatch repair_Homo sapiens_hsa034301.15164639
64Fat digestion and absorption_Homo sapiens_hsa049751.14062522
65Taste transduction_Homo sapiens_hsa047421.12405270
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12021109
67Cysteine and methionine metabolism_Homo sapiens_hsa002701.11845684
68Nicotine addiction_Homo sapiens_hsa050331.06811840
69Bile secretion_Homo sapiens_hsa049761.01646389
70Nucleotide excision repair_Homo sapiens_hsa034201.00948536
71Purine metabolism_Homo sapiens_hsa002300.97416304
72RNA transport_Homo sapiens_hsa030130.96832955
73Lysine degradation_Homo sapiens_hsa003100.94311777
74Sulfur relay system_Homo sapiens_hsa041220.93957020
75Parkinsons disease_Homo sapiens_hsa050120.93159785
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90898745
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89180181
78Pyruvate metabolism_Homo sapiens_hsa006200.85660951
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.80030738
80Biosynthesis of amino acids_Homo sapiens_hsa012300.79192455
81Vitamin B6 metabolism_Homo sapiens_hsa007500.78194627
82Primary immunodeficiency_Homo sapiens_hsa053400.75580680
83Huntingtons disease_Homo sapiens_hsa050160.75574022
84Olfactory transduction_Homo sapiens_hsa047400.68779668
85Glutathione metabolism_Homo sapiens_hsa004800.68549963
86Carbon metabolism_Homo sapiens_hsa012000.66153281
87Metabolic pathways_Homo sapiens_hsa011000.61211783
88Glycerolipid metabolism_Homo sapiens_hsa005610.58464067
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58319686
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55258470
91Galactose metabolism_Homo sapiens_hsa000520.54371271
92Sphingolipid metabolism_Homo sapiens_hsa006000.52433906
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.51084680
94Other glycan degradation_Homo sapiens_hsa005110.49323652
95Ovarian steroidogenesis_Homo sapiens_hsa049130.49322281
96Systemic lupus erythematosus_Homo sapiens_hsa053220.48762953
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47122418
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46420702
99Linoleic acid metabolism_Homo sapiens_hsa005910.46140189
100Cell cycle_Homo sapiens_hsa041100.46136492
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45461265
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43657631
103Spliceosome_Homo sapiens_hsa030400.43226644
104Pentose phosphate pathway_Homo sapiens_hsa000300.42374747
105Morphine addiction_Homo sapiens_hsa050320.40930153
106Serotonergic synapse_Homo sapiens_hsa047260.38277180
107Alzheimers disease_Homo sapiens_hsa050100.37798222
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36954468
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36107787
110Calcium signaling pathway_Homo sapiens_hsa040200.35394539
111p53 signaling pathway_Homo sapiens_hsa041150.35345510
112Hedgehog signaling pathway_Homo sapiens_hsa043400.35267920
113Arachidonic acid metabolism_Homo sapiens_hsa005900.33661624
114Fructose and mannose metabolism_Homo sapiens_hsa000510.33503694
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33100561
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32028862
117Regulation of autophagy_Homo sapiens_hsa041400.25303646
118Prion diseases_Homo sapiens_hsa050200.19949037
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19693459
120Pyrimidine metabolism_Homo sapiens_hsa002400.18009790
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16266125
122Protein digestion and absorption_Homo sapiens_hsa049740.15262173
123Insulin resistance_Homo sapiens_hsa049310.13095359
124Intestinal immune network for IgA production_Homo sapiens_hsa046720.12329094
125N-Glycan biosynthesis_Homo sapiens_hsa005100.11692609
126Fanconi anemia pathway_Homo sapiens_hsa034600.10761054
127Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09992620
128Fatty acid biosynthesis_Homo sapiens_hsa000610.07857330
129Lysosome_Homo sapiens_hsa041420.06490885
130Legionellosis_Homo sapiens_hsa051340.06349475
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.04468681
132NF-kappa B signaling pathway_Homo sapiens_hsa040640.01353397
133Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.00612108
134Hepatitis C_Homo sapiens_hsa05160-0.0455108
135Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.0388960
136Renin-angiotensin system_Homo sapiens_hsa04614-0.0383931
137Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0270600
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0255475

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