SFXN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sideroflexin family. The encoded protein is a transmembrane protein of the inner mitochondrial membrane, and is required for mitochondrial respiratory homeostasis and erythropoiesis. Mutations in this gene are associated with mitochondriopathy and macrocytic anemia. Alternatively spliced transcript variants have been found in this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)5.02945770
2axon ensheathment in central nervous system (GO:0032291)4.46527500
3central nervous system myelination (GO:0022010)4.46527500
4ribosomal small subunit biogenesis (GO:0042274)4.43940523
5presynaptic membrane assembly (GO:0097105)4.36683613
6neuron cell-cell adhesion (GO:0007158)4.36558625
7presynaptic membrane organization (GO:0097090)4.27512819
8oxidative phosphorylation (GO:0006119)4.25986521
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.22877629
10regulation of mitochondrial translation (GO:0070129)4.19114542
11ribosomal large subunit biogenesis (GO:0042273)4.16608474
12long-chain fatty acid biosynthetic process (GO:0042759)4.12888102
13purine nucleobase biosynthetic process (GO:0009113)3.98306084
14formation of translation preinitiation complex (GO:0001731)3.97999074
15ribosome assembly (GO:0042255)3.95404865
16DNA strand elongation involved in DNA replication (GO:0006271)3.87960106
17negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.87886589
18ribosomal small subunit assembly (GO:0000028)3.82435356
19telomere maintenance via semi-conservative replication (GO:0032201)3.82170343
20pseudouridine synthesis (GO:0001522)3.74555118
21protein deneddylation (GO:0000338)3.74214612
22DNA replication checkpoint (GO:0000076)3.73713287
23viral transcription (GO:0019083)3.72670860
24DNA strand elongation (GO:0022616)3.72297488
25protein targeting to mitochondrion (GO:0006626)3.72165378
26nucleobase biosynthetic process (GO:0046112)3.70183294
27protein neddylation (GO:0045116)3.69767982
28cullin deneddylation (GO:0010388)3.67499916
29ribonucleoprotein complex biogenesis (GO:0022613)3.67488884
30SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.64936927
31rRNA processing (GO:0006364)3.64428202
32translational termination (GO:0006415)3.63912751
33negative regulation of synaptic transmission, GABAergic (GO:0032229)3.62978617
34IMP biosynthetic process (GO:0006188)3.62559081
35regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.59979980
36peptidyl-histidine modification (GO:0018202)3.59687703
37rRNA modification (GO:0000154)3.57753583
38cotranslational protein targeting to membrane (GO:0006613)3.57604770
39negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.55788276
40negative regulation of ligase activity (GO:0051352)3.55788276
41translation (GO:0006412)3.55277361
42protein targeting to ER (GO:0045047)3.54887362
43positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.53993561
44anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.50816091
45mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.48348712
46cellular component biogenesis (GO:0044085)3.47987006
47rRNA metabolic process (GO:0016072)3.45672071
48dopamine transport (GO:0015872)3.44167346
49establishment of protein localization to endoplasmic reticulum (GO:0072599)3.41364641
50maturation of 5.8S rRNA (GO:0000460)3.40797834
51nucleobase-containing small molecule interconversion (GO:0015949)3.40294483
52protein localization to mitochondrion (GO:0070585)3.40247941
53tricarboxylic acid cycle (GO:0006099)3.39423350
54translational elongation (GO:0006414)3.39221388
55ATP synthesis coupled proton transport (GO:0015986)3.38221208
56energy coupled proton transport, down electrochemical gradient (GO:0015985)3.38221208
57protein localization to endoplasmic reticulum (GO:0070972)3.37547173
58establishment of protein localization to mitochondrion (GO:0072655)3.37457401
59translational initiation (GO:0006413)3.37441692
60inner mitochondrial membrane organization (GO:0007007)3.37225029
61startle response (GO:0001964)3.35354400
62chaperone-mediated protein transport (GO:0072321)3.31114001
63ribosome biogenesis (GO:0042254)3.31086814
64pteridine-containing compound biosynthetic process (GO:0042559)3.30731839
65chromatin remodeling at centromere (GO:0031055)3.29034680
66CENP-A containing nucleosome assembly (GO:0034080)3.25555424
67establishment of integrated proviral latency (GO:0075713)3.24748445
68IMP metabolic process (GO:0046040)3.24588325
69regulation of cellular amino acid metabolic process (GO:0006521)3.24268105
70postsynaptic membrane organization (GO:0001941)3.23983650
71telomere maintenance via recombination (GO:0000722)3.23054070
72tRNA aminoacylation (GO:0043039)3.18850336
73amino acid activation (GO:0043038)3.18850336
74gamma-aminobutyric acid signaling pathway (GO:0007214)3.17844942
75tRNA aminoacylation for protein translation (GO:0006418)3.17682876
76L-serine metabolic process (GO:0006563)3.15174928
77spliceosomal snRNP assembly (GO:0000387)3.13414734
78aerobic respiration (GO:0009060)3.13267140
79regulation of dopamine metabolic process (GO:0042053)3.12816440
80regulation of catecholamine metabolic process (GO:0042069)3.12816440
81protein complex biogenesis (GO:0070271)3.12661556
82deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.12263765
83positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.11281239
84positive regulation of synapse assembly (GO:0051965)3.09562042
85transcription from mitochondrial promoter (GO:0006390)3.09051756
86mitotic recombination (GO:0006312)3.08277644
87folic acid-containing compound biosynthetic process (GO:0009396)3.08134117
88respiratory electron transport chain (GO:0022904)3.07748238
89DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.06852733
90pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.05344492
91signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.04972213
92signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.04972213
93signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.04972213
94neuronal action potential propagation (GO:0019227)3.04347059
95intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.04282038
96signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.04282038
97signal transduction involved in DNA integrity checkpoint (GO:0072401)3.03624993
98signal transduction involved in DNA damage checkpoint (GO:0072422)3.03624993
99pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.03070613
100mitochondrial transport (GO:0006839)3.02444315
101ionotropic glutamate receptor signaling pathway (GO:0035235)3.02273502
102glutamate receptor signaling pathway (GO:0007215)3.01597022
103nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.00488237
104guanosine-containing compound biosynthetic process (GO:1901070)2.99564815
105transmission of nerve impulse (GO:0019226)2.99500944
106L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.98488507
107electron transport chain (GO:0022900)2.98153271
108signal transduction involved in cell cycle checkpoint (GO:0072395)2.96813829
109positive regulation of ligase activity (GO:0051351)2.96651637
110protein localization to synapse (GO:0035418)2.94130273
111negative regulation of neurotransmitter transport (GO:0051589)2.93949099
112mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.93513460
113mitochondrial respiratory chain complex I assembly (GO:0032981)2.93513460
114NADH dehydrogenase complex assembly (GO:0010257)2.93513460
115positive regulation of protein homodimerization activity (GO:0090073)2.93283950
116cerebral cortex radially oriented cell migration (GO:0021799)2.92343130
117developmental pigmentation (GO:0048066)2.92052122
118nonmotile primary cilium assembly (GO:0035058)2.87473006
119GTP biosynthetic process (GO:0006183)2.87456369
120neurotransmitter uptake (GO:0001504)2.87369797
121righting reflex (GO:0060013)2.84635675
122neuron-neuron synaptic transmission (GO:0007270)2.81476247
123G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.81114172
124transcription elongation from RNA polymerase III promoter (GO:0006385)2.80843819
125termination of RNA polymerase III transcription (GO:0006386)2.80843819
126regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.79636946
127dopamine biosynthetic process (GO:0042416)2.78357207
128proteasome assembly (GO:0043248)2.75819709
129synaptic transmission, glutamatergic (GO:0035249)2.75623673
130serotonin receptor signaling pathway (GO:0007210)2.75546416
131regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.73300285
132opioid receptor signaling pathway (GO:0038003)2.69482631
133preassembly of GPI anchor in ER membrane (GO:0016254)2.68940398
134deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.67469158
135mannosylation (GO:0097502)2.67451370
136mitochondrial respiratory chain complex assembly (GO:0033108)2.66950731
137GPI anchor biosynthetic process (GO:0006506)2.66114820
138protein localization to cilium (GO:0061512)2.66056700
139vocalization behavior (GO:0071625)2.65681109
140fatty acid elongation (GO:0030497)2.65498884
141neuron recognition (GO:0008038)2.63107803
142respiratory chain complex IV assembly (GO:0008535)2.61082132
143protein-cofactor linkage (GO:0018065)2.59056354
144positive regulation of action potential (GO:0045760)2.57409940
145response to redox state (GO:0051775)2.55831660
146regulation of respiratory gaseous exchange (GO:0043576)2.54536483
1477-methylguanosine RNA capping (GO:0009452)2.50483057
148RNA capping (GO:0036260)2.50483057
149regulation of respiratory system process (GO:0044065)2.49478305
150positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.48941085
1517-methylguanosine mRNA capping (GO:0006370)2.48111751
152positive regulation of meiosis (GO:0045836)2.48041103
153regulation of synapse assembly (GO:0051963)2.45767124
154GPI anchor metabolic process (GO:0006505)2.45608149
155establishment of protein localization to mitochondrial membrane (GO:0090151)2.44759183
156dendrite development (GO:0016358)2.44753290
157regulation of feeding behavior (GO:0060259)2.44264881
158negative regulation of protein localization to cell surface (GO:2000009)2.43321322
159regulation of timing of cell differentiation (GO:0048505)2.43106264
160response to cocaine (GO:0042220)2.42709770
161glycerophospholipid catabolic process (GO:0046475)2.41523587
162regulation of pigment cell differentiation (GO:0050932)2.39703945
163regulation of glutamate secretion (GO:0014048)2.37584627
164positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.36660759
165cytochrome complex assembly (GO:0017004)2.34225408
166adult walking behavior (GO:0007628)2.32670394
167intraciliary transport (GO:0042073)2.32336307
168histone H2B ubiquitination (GO:0033523)2.31400649
169axoneme assembly (GO:0035082)2.30634839
170negative regulation of execution phase of apoptosis (GO:1900118)2.30228730
171DNA damage response, detection of DNA damage (GO:0042769)2.29764014
172limb bud formation (GO:0060174)2.29054036
173regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.26716236
174positive regulation of meiotic cell cycle (GO:0051446)2.26610285
175regulation of glutamate receptor signaling pathway (GO:1900449)2.26576205
176positive regulation of amino acid transport (GO:0051957)2.24223676
177synaptic vesicle exocytosis (GO:0016079)2.23857923
178cilium movement (GO:0003341)2.23735074
179oligodendrocyte differentiation (GO:0048709)2.23453166
180transferrin transport (GO:0033572)2.22967782
181regulation of protein kinase A signaling (GO:0010738)2.22787783
182catecholamine transport (GO:0051937)2.20246076

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.27636749
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.54675164
3EZH2_22144423_ChIP-Seq_EOC_Human4.07088367
4GBX2_23144817_ChIP-Seq_PC3_Human4.03233708
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.83756525
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.83181600
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.63648470
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.57351476
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.43914631
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.38827861
11MYC_18358816_ChIP-ChIP_MESCs_Mouse3.21302836
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.99261175
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.95201382
14* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.79811597
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.77678823
16TAF15_26573619_Chip-Seq_HEK293_Human2.74670339
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.73805220
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.69678995
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.66089607
20* DCP1A_22483619_ChIP-Seq_HELA_Human2.55171377
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.53244611
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.52063518
23BMI1_23680149_ChIP-Seq_NPCS_Mouse2.45379783
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.42124320
25VDR_23849224_ChIP-Seq_CD4+_Human2.36661210
26XRN2_22483619_ChIP-Seq_HELA_Human2.35543242
27FOXP3_21729870_ChIP-Seq_TREG_Human2.34048230
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32643297
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.30275702
30* SRF_21415370_ChIP-Seq_HL-1_Mouse2.28288161
31JARID2_20064375_ChIP-Seq_MESCs_Mouse2.26642133
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24887132
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.24387771
34GABP_19822575_ChIP-Seq_HepG2_Human2.22918369
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.19602805
36TTF2_22483619_ChIP-Seq_HELA_Human2.19461374
37FUS_26573619_Chip-Seq_HEK293_Human2.18027173
38VDR_22108803_ChIP-Seq_LS180_Human2.15620934
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.13376319
40POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12534881
41CBX2_27304074_Chip-Seq_ESCs_Mouse2.06882483
42EZH2_27304074_Chip-Seq_ESCs_Mouse2.05096898
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.04002422
44ELK1_19687146_ChIP-ChIP_HELA_Human2.03627285
45AR_21909140_ChIP-Seq_LNCAP_Human2.03409297
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.02398354
47EED_16625203_ChIP-ChIP_MESCs_Mouse2.02186954
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96679295
49IGF1R_20145208_ChIP-Seq_DFB_Human1.96202225
50SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.92793470
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.92067187
52SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.91778322
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90911538
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.89820394
55P300_19829295_ChIP-Seq_ESCs_Human1.88961207
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.88569461
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87573218
58RNF2_27304074_Chip-Seq_NSC_Mouse1.87383596
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84113244
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83325355
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82815056
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.82698578
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82642924
64SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.82454687
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.81145359
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.80834837
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.78476381
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.77660163
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.77039191
70FOXM1_23109430_ChIP-Seq_U2OS_Human1.75607134
71KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.71848680
72ER_23166858_ChIP-Seq_MCF-7_Human1.69966152
73JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69689860
74SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69021009
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.60155478
76KDM5A_27292631_Chip-Seq_BREAST_Human1.58563159
77EZH2_18974828_ChIP-Seq_MESCs_Mouse1.58109213
78RNF2_18974828_ChIP-Seq_MESCs_Mouse1.58109213
79EWS_26573619_Chip-Seq_HEK293_Human1.56704670
80REST_21632747_ChIP-Seq_MESCs_Mouse1.56629251
81CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.56550970
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56104972
83PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.55909021
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53727530
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52890356
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52581130
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52307699
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.51536832
89PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51283998
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.51165901
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.50882118
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48984043
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47440791
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.45645716
95MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44183201
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43483606
97MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.41885871
98RNF2_27304074_Chip-Seq_ESCs_Mouse1.41596090
99SMAD4_21799915_ChIP-Seq_A2780_Human1.41341179
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.40996447
101HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.40653145
102SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40445086
103STAT3_18555785_Chip-Seq_ESCs_Mouse1.40213920
104E2F1_18555785_Chip-Seq_ESCs_Mouse1.40072353
105EZH2_27294783_Chip-Seq_ESCs_Mouse1.40065663
106NFE2_27457419_Chip-Seq_LIVER_Mouse1.39440013
107ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39433732
108TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39073336
109ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.38445693
110RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38142930
111SUZ12_18555785_Chip-Seq_ESCs_Mouse1.37875643
112PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36602096
113P53_22387025_ChIP-Seq_ESCs_Mouse1.35627740
114* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35552329
115IRF1_19129219_ChIP-ChIP_H3396_Human1.35328782
116EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.35274744
117SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33843080
118CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33833984
119SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32779409
120OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32760908
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31458510
122P300_18555785_Chip-Seq_ESCs_Mouse1.30659564
123MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30647656
124PIAS1_25552417_ChIP-Seq_VCAP_Human1.29593737
125CMYC_18555785_Chip-Seq_ESCs_Mouse1.29052840
126MYC_18940864_ChIP-ChIP_HL60_Human1.28912411
127* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.28426893
128TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28014555
129TFEB_21752829_ChIP-Seq_HELA_Human1.27882100
130NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25828779
131RUNX1_27457419_Chip-Seq_LIVER_Mouse1.25242586
132KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23355065
133FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23306281
134NMYC_18555785_Chip-Seq_ESCs_Mouse1.23103443
135EZH2_27294783_Chip-Seq_NPCs_Mouse1.22897006
136ZNF263_19887448_ChIP-Seq_K562_Human1.22666277
137SOX2_18555785_Chip-Seq_ESCs_Mouse1.21860747
138FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21805667
139POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19528590
140CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18194181
141DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17371095
142TAL1_26923725_Chip-Seq_HPCs_Mouse1.17150601
143GABP_17652178_ChIP-ChIP_JURKAT_Human1.16154336
144IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14865602
145* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13522964
146KLF4_18555785_Chip-Seq_ESCs_Mouse1.13386182
147STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11961431
148SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11459900
149MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11130480
150ZFX_18555785_Chip-Seq_ESCs_Mouse1.10967504
151CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10332691
152SMAD_19615063_ChIP-ChIP_OVARY_Human1.09103404
153OCT4_18555785_Chip-Seq_ESCs_Mouse1.09079587
154CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08513181
155JUN_21703547_ChIP-Seq_K562_Human1.08287794
156ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08277986
157RUNX2_22187159_ChIP-Seq_PCA_Human1.07054950
158REST_18959480_ChIP-ChIP_MESCs_Mouse1.06636028
159PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05623582
160AR_25329375_ChIP-Seq_VCAP_Human1.05500036
161SMAD1_18555785_Chip-Seq_ESCs_Mouse1.04061069
162PU1_27457419_Chip-Seq_LIVER_Mouse1.03971561
163CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02434305
164STAT3_23295773_ChIP-Seq_U87_Human1.01230354
165TCF4_23295773_ChIP-Seq_U87_Human1.01152159
166SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00439756
167KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99877031
168NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.99874218
169POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99433093
170TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99433093
171P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99025572
172ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97662609
173TBX5_21415370_ChIP-Seq_HL-1_Mouse0.97399347
174SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.97022882
175CIITA_25753668_ChIP-Seq_RAJI_Human0.96263619
176SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92342316
177GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92227089
178TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91207059
179CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90481056
180SOX17_20123909_ChIP-Seq_XEN_Mouse0.89826124
181CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86914647
182ELK1_22589737_ChIP-Seq_MCF10A_Human0.85343754
183CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85237579
184ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.81745384
185FOXP1_21924763_ChIP-Seq_HESCs_Human0.81303409
186DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80918487
187NOTCH1_21737748_ChIP-Seq_TLL_Human0.80127059
188* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.76930837
189HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76688773
190TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.76301414
191CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75083811
192CHD1_26751641_Chip-Seq_LNCaP_Human0.70298490

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.57659775
2MP0003880_abnormal_central_pattern4.46646444
3MP0010094_abnormal_chromosome_stability4.41631694
4MP0003693_abnormal_embryo_hatching4.16407757
5MP0003111_abnormal_nucleus_morphology3.77346658
6MP0004957_abnormal_blastocyst_morpholog3.76117338
7MP0006036_abnormal_mitochondrial_physio3.61073805
8MP0001188_hyperpigmentation3.23596168
9MP0003077_abnormal_cell_cycle3.13563738
10MP0006292_abnormal_olfactory_placode2.94271063
11MP0006035_abnormal_mitochondrial_morpho2.71646775
12MP0003186_abnormal_redox_activity2.70384000
13MP0001529_abnormal_vocalization2.67126626
14MP0003136_yellow_coat_color2.63450125
15MP0005423_abnormal_somatic_nervous2.62254571
16MP0006276_abnormal_autonomic_nervous2.57893729
17MP0005409_darkened_coat_color2.54358345
18MP0008932_abnormal_embryonic_tissue2.53397357
19MP0008007_abnormal_cellular_replicative2.50643710
20MP0001905_abnormal_dopamine_level2.45669368
21MP0001968_abnormal_touch/_nociception2.38922670
22MP0009697_abnormal_copulation2.38247304
23MP0009745_abnormal_behavioral_response2.37233457
24MP0005171_absent_coat_pigmentation2.29895807
25MP0002272_abnormal_nervous_system2.20737506
26MP0003635_abnormal_synaptic_transmissio2.19793389
27MP0001486_abnormal_startle_reflex2.19772017
28MP0009046_muscle_twitch2.14945432
29MP0002736_abnormal_nociception_after2.13554728
30MP0002064_seizures2.09652357
31MP0005646_abnormal_pituitary_gland2.09048380
32MP0002572_abnormal_emotion/affect_behav2.05709914
33MP0001986_abnormal_taste_sensitivity2.03249173
34MP0004859_abnormal_synaptic_plasticity2.01662798
35MP0005645_abnormal_hypothalamus_physiol1.99075160
36MP0003646_muscle_fatigue1.98514657
37MP0002735_abnormal_chemical_nociception1.98217390
38MP0000566_synostosis1.94904733
39MP0004142_abnormal_muscle_tone1.87237134
40MP0002638_abnormal_pupillary_reflex1.83858057
41MP0002063_abnormal_learning/memory/cond1.83336897
42MP0005408_hypopigmentation1.83228198
43MP0004270_analgesia1.82754334
44MP0002734_abnormal_mechanical_nocicepti1.80427136
45MP0003787_abnormal_imprinting1.77552069
46MP0004742_abnormal_vestibular_system1.75934118
47MP0000749_muscle_degeneration1.71796647
48MP0000778_abnormal_nervous_system1.69390468
49MP0002102_abnormal_ear_morphology1.68304752
50MP0002067_abnormal_sensory_capabilities1.68124831
51MP0001501_abnormal_sleep_pattern1.66392522
52MP0001440_abnormal_grooming_behavior1.66335207
53MP0001984_abnormal_olfaction1.56907095
54MP0000358_abnormal_cell_content/1.55407961
55MP0001764_abnormal_homeostasis1.55357800
56MP0001730_embryonic_growth_arrest1.55191838
57MP0003123_paternal_imprinting1.55048186
58MP0005551_abnormal_eye_electrophysiolog1.54622385
59MP0008877_abnormal_DNA_methylation1.51113875
60MP0000350_abnormal_cell_proliferation1.49783087
61MP0005330_cardiomyopathy1.49690387
62MP0002876_abnormal_thyroid_physiology1.47806034
63MP0001970_abnormal_pain_threshold1.43549081
64MP0003122_maternal_imprinting1.42374252
65MP0002837_dystrophic_cardiac_calcinosis1.42050827
66MP0002557_abnormal_social/conspecific_i1.40669899
67MP0001661_extended_life_span1.40616188
68MP0001485_abnormal_pinna_reflex1.40112616
69MP0002184_abnormal_innervation1.39696237
70MP0009379_abnormal_foot_pigmentation1.38440593
71MP0002160_abnormal_reproductive_system1.36433364
72MP0000631_abnormal_neuroendocrine_gland1.35569370
73MP0005332_abnormal_amino_acid1.34315642
74MP0002396_abnormal_hematopoietic_system1.32318480
75MP0000313_abnormal_cell_death1.31900879
76MP0000026_abnormal_inner_ear1.31312991
77MP0002132_abnormal_respiratory_system1.29914851
78MP0005379_endocrine/exocrine_gland_phen1.29337576
79MP0002733_abnormal_thermal_nociception1.27459093
80MP0001963_abnormal_hearing_physiology1.27174764
81MP0008995_early_reproductive_senescence1.26627262
82MP0001502_abnormal_circadian_rhythm1.25266226
83MP0005386_behavior/neurological_phenoty1.25084508
84MP0004924_abnormal_behavior1.25084508
85MP0002090_abnormal_vision1.24148763
86MP0001697_abnormal_embryo_size1.23630118
87MP0000015_abnormal_ear_pigmentation1.21003353
88MP0002234_abnormal_pharynx_morphology1.19285880
89MP0003938_abnormal_ear_development1.16993494
90MP0010386_abnormal_urinary_bladder1.15220928
91MP0005451_abnormal_body_composition1.13859639
92MP0002277_abnormal_respiratory_mucosa1.13451484
93MP0000920_abnormal_myelination1.12834299
94MP0002752_abnormal_somatic_nervous1.12438350
95MP0002822_catalepsy1.12366008
96MP0002938_white_spotting1.11953363
97MP0002269_muscular_atrophy1.10862360
98MP0008260_abnormal_autophagy1.10456031
99MP0004233_abnormal_muscle_weight1.10384375
100MP0004381_abnormal_hair_follicle1.10050036
101MP0002163_abnormal_gland_morphology1.09318032
102MP0002882_abnormal_neuron_morphology1.09113924
103MP0002080_prenatal_lethality1.09103095
104MP0010234_abnormal_vibrissa_follicle1.06789914
105MP0001727_abnormal_embryo_implantation1.03440382
106MP0005380_embryogenesis_phenotype1.01728358
107MP0001672_abnormal_embryogenesis/_devel1.01728358
108MP0002751_abnormal_autonomic_nervous1.00629841
109MP0002019_abnormal_tumor_incidence0.99661365
110MP0003121_genomic_imprinting0.98926365
111MP0002066_abnormal_motor_capabilities/c0.96575954
112MP0005174_abnormal_tail_pigmentation0.96527085
113MP0006072_abnormal_retinal_apoptosis0.96464866
114MP0002210_abnormal_sex_determination0.94916334
115MP0005266_abnormal_metabolism0.94761013
116MP0004885_abnormal_endolymph0.94106346
117MP0000955_abnormal_spinal_cord0.93186697
118MP0002139_abnormal_hepatobiliary_system0.93137627
119MP0002229_neurodegeneration0.93070368
120MP0005394_taste/olfaction_phenotype0.92705465
121MP0005499_abnormal_olfactory_system0.92705465
122MP0005501_abnormal_skin_physiology0.92013219
123MP0000751_myopathy0.90735110
124MP0008875_abnormal_xenobiotic_pharmacok0.90640308
125MP0008789_abnormal_olfactory_epithelium0.90054879
126MP0000372_irregular_coat_pigmentation0.89863382
127MP0005636_abnormal_mineral_homeostasis0.88287535
128MP0000747_muscle_weakness0.87512441
129MP0008057_abnormal_DNA_replication0.86051935
130MP0003567_abnormal_fetal_cardiomyocyte0.86033809
131MP0005319_abnormal_enzyme/_coenzyme0.85750039
132MP0008569_lethality_at_weaning0.85155377
133MP0005253_abnormal_eye_physiology0.85151224
134MP0001929_abnormal_gametogenesis0.84769661
135MP0004185_abnormal_adipocyte_glucose0.83828235
136MP0003984_embryonic_growth_retardation0.83790835
137MP0002095_abnormal_skin_pigmentation0.83587602
138MP0002877_abnormal_melanocyte_morpholog0.82316440
139MP0008058_abnormal_DNA_repair0.80694211
140MP0003941_abnormal_skin_development0.80152128
141MP0002088_abnormal_embryonic_growth/wei0.79463947
142MP0010307_abnormal_tumor_latency0.78304301
143MP0004147_increased_porphyrin_level0.78106619
144MP0005075_abnormal_melanosome_morpholog0.77511998
145MP0001145_abnormal_male_reproductive0.77302234
146MP0001881_abnormal_mammary_gland0.76641166
147MP0000049_abnormal_middle_ear0.75972697
148MP0003879_abnormal_hair_cell0.74988757
149MP0003718_maternal_effect0.74825763
150MP0009672_abnormal_birth_weight0.74346887
151MP0001664_abnormal_digestion0.73582688
152MP0005410_abnormal_fertilization0.72779810
153MP0000653_abnormal_sex_gland0.72423865
154MP0008873_increased_physiological_sensi0.71220490
155MP0002152_abnormal_brain_morphology0.70911724
156MP0005389_reproductive_system_phenotype0.69616517
157MP0003786_premature_aging0.68998974
158MP0001853_heart_inflammation0.67952818
159MP0010030_abnormal_orbit_morphology0.67313831
160MP0003950_abnormal_plasma_membrane0.66264731
161MP0004036_abnormal_muscle_relaxation0.65774979
162MP0003315_abnormal_perineum_morphology0.65752356
163MP0000678_abnormal_parathyroid_gland0.65615965
164MP0004215_abnormal_myocardial_fiber0.65281913
165MP0001666_abnormal_nutrient_absorption0.64776687
166MP0005195_abnormal_posterior_eye0.64469170
167MP0003698_abnormal_male_reproductive0.64460806
168MP0001293_anophthalmia0.64229646
169MP0003137_abnormal_impulse_conducting0.63957847
170MP0005187_abnormal_penis_morphology0.63543869
171MP0004145_abnormal_muscle_electrophysio0.63029406
172MP0003221_abnormal_cardiomyocyte_apopto0.60970042
173MP0000759_abnormal_skeletal_muscle0.60691431
174MP0002085_abnormal_embryonic_tissue0.60680125
175MP0005395_other_phenotype0.60478404
176MP0009333_abnormal_splenocyte_physiolog0.60050971
177MP0005084_abnormal_gallbladder_morpholo0.59726398
178MP0005367_renal/urinary_system_phenotyp0.58705628
179MP0000516_abnormal_urinary_system0.58705628

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolysis (HP:0004366)4.07114583
2Increased serum pyruvate (HP:0003542)4.02641060
3Focal motor seizures (HP:0011153)3.87727783
4Increased intramyocellular lipid droplets (HP:0012240)3.79635635
5Cerebral edema (HP:0002181)3.69693179
6Acute necrotizing encephalopathy (HP:0006965)3.62754260
7Microvesicular hepatic steatosis (HP:0001414)3.61052336
8* Increased serum lactate (HP:0002151)3.57413160
9* Lactic acidosis (HP:0003128)3.44237817
10Abnormal hair whorl (HP:0010721)3.33486542
11Increased muscle lipid content (HP:0009058)3.28543985
12Mitochondrial inheritance (HP:0001427)3.24009469
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.17311113
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.17311113
15Medial flaring of the eyebrow (HP:0010747)3.15121084
16Reticulocytopenia (HP:0001896)3.13943265
17Type I transferrin isoform profile (HP:0003642)3.13381661
18Progressive muscle weakness (HP:0003323)3.06806818
19Respiratory failure (HP:0002878)3.05856449
20Renal Fanconi syndrome (HP:0001994)3.05053673
21Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.04294569
22Abnormal mitochondria in muscle tissue (HP:0008316)3.01869949
23Progressive macrocephaly (HP:0004481)3.01001692
24Febrile seizures (HP:0002373)2.99406292
25Epileptic encephalopathy (HP:0200134)2.89486024
26* Macrocytic anemia (HP:0001972)2.87363475
27Abnormality of methionine metabolism (HP:0010901)2.83341750
28Parakeratosis (HP:0001036)2.81065311
29Gait imbalance (HP:0002141)2.80151078
30Increased hepatocellular lipid droplets (HP:0006565)2.79533292
31Respiratory difficulties (HP:0002880)2.75611489
32Congenital primary aphakia (HP:0007707)2.75000545
33Multiple enchondromatosis (HP:0005701)2.73094754
34Aplasia/Hypoplasia of the sacrum (HP:0008517)2.72946751
35Abnormality of alanine metabolism (HP:0010916)2.69956631
36Hyperalaninemia (HP:0003348)2.69956631
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.69956631
38Abnormal ciliary motility (HP:0012262)2.69346799
39Atonic seizures (HP:0010819)2.66568994
40Reduced antithrombin III activity (HP:0001976)2.65606100
41Optic disc pallor (HP:0000543)2.65078120
42Hypothermia (HP:0002045)2.64804426
43Nephrogenic diabetes insipidus (HP:0009806)2.64555758
44Duplicated collecting system (HP:0000081)2.64324436
45Increased CSF lactate (HP:0002490)2.61275415
46Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.60617831
47Lethargy (HP:0001254)2.59666836
48Abnormality of cells of the erythroid lineage (HP:0012130)2.57937977
49Dynein arm defect of respiratory motile cilia (HP:0012255)2.57772188
50Absent/shortened dynein arms (HP:0200106)2.57772188
51Acute encephalopathy (HP:0006846)2.56900022
52Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.56699655
53Abnormality of the renal collecting system (HP:0004742)2.54249866
54Hepatocellular necrosis (HP:0001404)2.53408864
55Abnormal respiratory motile cilium morphology (HP:0005938)2.51887714
56Abnormal respiratory epithelium morphology (HP:0012253)2.51887714
57Abnormality of the preputium (HP:0100587)2.50838606
58Ragged-red muscle fibers (HP:0003200)2.50154900
593-Methylglutaconic aciduria (HP:0003535)2.50047605
60Abnormal number of erythroid precursors (HP:0012131)2.49221869
61Abnormal protein glycosylation (HP:0012346)2.48682421
62Abnormal glycosylation (HP:0012345)2.48682421
63Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.48682421
64Abnormal protein N-linked glycosylation (HP:0012347)2.48682421
65Dicarboxylic aciduria (HP:0003215)2.48439913
66Abnormality of dicarboxylic acid metabolism (HP:0010995)2.48439913
67Abnormality of aromatic amino acid family metabolism (HP:0004338)2.47562600
68Genital tract atresia (HP:0001827)2.38876308
69True hermaphroditism (HP:0010459)2.37203354
70Vaginal atresia (HP:0000148)2.36887503
71CNS demyelination (HP:0007305)2.36066401
72Generalized aminoaciduria (HP:0002909)2.33491568
73Chromosomal breakage induced by crosslinking agents (HP:0003221)2.32274132
74Broad-based gait (HP:0002136)2.31834669
75Abnormal respiratory motile cilium physiology (HP:0012261)2.30065357
76Septo-optic dysplasia (HP:0100842)2.29089663
77Degeneration of anterior horn cells (HP:0002398)2.28627225
78Abnormality of the anterior horn cell (HP:0006802)2.28627225
79Pancytopenia (HP:0001876)2.27079323
80Methylmalonic acidemia (HP:0002912)2.26799299
81Abnormality of serum amino acid levels (HP:0003112)2.26510962
82Pancreatic fibrosis (HP:0100732)2.25697118
83Hyperglycinemia (HP:0002154)2.25559267
84Methylmalonic aciduria (HP:0012120)2.24140618
85Hyperventilation (HP:0002883)2.24128050
86Hypoglycemic coma (HP:0001325)2.21784434
87Testicular atrophy (HP:0000029)2.21589610
88Abnormality of renal resorption (HP:0011038)2.21203984
89Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.20358877
90Aplastic anemia (HP:0001915)2.20274393
91Meckel diverticulum (HP:0002245)2.19911228
92Degeneration of the lateral corticospinal tracts (HP:0002314)2.18734063
93Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.18734063
94Neoplasm of the adrenal gland (HP:0100631)2.16124260
95Gout (HP:0001997)2.15553321
96Patchy hypopigmentation of hair (HP:0011365)2.15488777
97Palpitations (HP:0001962)2.13770504
98Hypokinesia (HP:0002375)2.12161898
99Abnormality of aspartate family amino acid metabolism (HP:0010899)2.11325706
100Aplasia/Hypoplasia of the uvula (HP:0010293)2.10223758
101Megaloblastic anemia (HP:0001889)2.08559286
102Rhabdomyolysis (HP:0003201)2.08333045
103Nemaline bodies (HP:0003798)2.08070459
104Abnormality of the ileum (HP:0001549)2.07714653
105White forelock (HP:0002211)2.07478806
106Abnormality of chromosome stability (HP:0003220)2.06305704
107Poor coordination (HP:0002370)2.05958630
108Progressive external ophthalmoplegia (HP:0000590)2.04594310
109Pancreatic cysts (HP:0001737)2.04316657
110Cerebral hypomyelination (HP:0006808)2.02651142
111Molar tooth sign on MRI (HP:0002419)2.02246474
112Abnormality of midbrain morphology (HP:0002418)2.02246474
113Nausea (HP:0002018)2.02142124
114Aplasia/Hypoplasia of the lens (HP:0008063)2.00342622
115Pancreatic islet-cell hyperplasia (HP:0004510)1.99437814
116Lipid accumulation in hepatocytes (HP:0006561)1.97620643
117Exercise-induced muscle cramps (HP:0003710)1.97601615
118Limb dystonia (HP:0002451)1.97475570
119Exercise intolerance (HP:0003546)1.97429604
120Retinal dysplasia (HP:0007973)1.96692051
121Abnormality of urine glucose concentration (HP:0011016)1.95773024
122Glycosuria (HP:0003076)1.95773024
123Focal seizures (HP:0007359)1.95638975
124Microretrognathia (HP:0000308)1.95450410
125Hyperinsulinemic hypoglycemia (HP:0000825)1.95057971
126Aplasia/Hypoplasia of the tibia (HP:0005772)1.94087601
127Optic nerve hypoplasia (HP:0000609)1.94011273
128Leukodystrophy (HP:0002415)1.93919413
129Chromsome breakage (HP:0040012)1.93428210
130Hyperammonemia (HP:0001987)1.93191295
131Muscle fiber inclusion bodies (HP:0100299)1.92994488
132Emotional lability (HP:0000712)1.92492008
133Abnormality of the septum pellucidum (HP:0007375)1.91954525
134Abnormality of incisor morphology (HP:0011063)1.91434607
135Absent septum pellucidum (HP:0001331)1.89528493
136Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.88298659
137Progressive cerebellar ataxia (HP:0002073)1.88258842
138Pallor (HP:0000980)1.87646230
139Abnormality of the labia minora (HP:0012880)1.87428886
140Birth length less than 3rd percentile (HP:0003561)1.86667481
141Dialeptic seizures (HP:0011146)1.86605811
142Metabolic acidosis (HP:0001942)1.85730578
143Myoglobinuria (HP:0002913)1.85475281
144Fetal akinesia sequence (HP:0001989)1.84445138
145Anomalous pulmonary venous return (HP:0010772)1.83623807
146Aganglionic megacolon (HP:0002251)1.83085230
147Nasolacrimal duct obstruction (HP:0000579)1.82998201
148Abnormality of secondary sexual hair (HP:0009888)1.82962060
149Abnormality of the axillary hair (HP:0100134)1.82962060
150Esotropia (HP:0000565)1.81743583
151Conical tooth (HP:0000698)1.81170239
152Short tibia (HP:0005736)1.81013234
153Congenital stationary night blindness (HP:0007642)1.79978571
154Absence seizures (HP:0002121)1.79450183
155Spastic paraparesis (HP:0002313)1.78692850
156Preaxial hand polydactyly (HP:0001177)1.78441729
157Abnormality of glycine metabolism (HP:0010895)1.78018206
158Abnormality of serine family amino acid metabolism (HP:0010894)1.78018206
159Median cleft lip (HP:0000161)1.77865287
160Protruding tongue (HP:0010808)1.76110379
161Morphological abnormality of the inner ear (HP:0011390)1.74158925
162Cupped ear (HP:0000378)1.73840344
163Aplasia/Hypoplasia of the fovea (HP:0008060)1.73725489
164Hypoplasia of the fovea (HP:0007750)1.73725489
165Nephronophthisis (HP:0000090)1.72065729
166Congenital sensorineural hearing impairment (HP:0008527)1.71822316
167Attenuation of retinal blood vessels (HP:0007843)1.70087010
168Type 2 muscle fiber atrophy (HP:0003554)1.69886664
169Adrenal hypoplasia (HP:0000835)1.69759571
170Duplication of thumb phalanx (HP:0009942)1.68591782
171Fair hair (HP:0002286)1.68394452
172Supernumerary spleens (HP:0009799)1.68174071
173Inability to walk (HP:0002540)1.66859788
174Exertional dyspnea (HP:0002875)1.65744848
175Hepatic necrosis (HP:0002605)1.65408711
176Abnormality of the lacrimal duct (HP:0011481)1.65250396
177Hypoplastic heart (HP:0001961)1.64815331

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.48561860
2NME24.19238469
3VRK23.87580720
4STK163.15289011
5TNIK3.06195314
6NEK12.66320641
7CDC72.62596718
8PDK22.54598490
9BMPR1B2.46344919
10MAP2K72.44343650
11NTRK32.30795008
12TTK2.10296962
13IRAK32.08263280
14PNCK1.97374729
15MKNK21.95126456
16SCYL21.94835307
17EPHA41.94316053
18BCKDK1.88652887
19OXSR11.78062195
20MARK11.73102252
21PRPF4B1.71376994
22PBK1.68998263
23ADRBK21.68183433
24NEK61.67916624
25IRAK41.67719184
26NME11.62931828
27BMPR21.59146891
28IRAK21.56145662
29NUAK11.55512537
30MAPK131.53139974
31GRK71.52171805
32STK391.51861923
33MAP3K121.48308439
34PLK21.44364944
35SIK31.41762346
36OBSCN1.41026474
37CDK191.40299782
38ZAK1.37158247
39VRK11.35833995
40MAP3K41.35374977
41PLK11.34695765
42BCR1.34072010
43MKNK11.33724994
44TRIM281.30303090
45MUSK1.28279426
46TAF11.20583202
47WEE11.19876914
48CHEK21.19498025
49TLK11.19371819
50PLK41.18897359
51RPS6KB21.14410850
52ATR1.13866326
53MAPKAPK51.10649186
54AKT31.10321755
55CAMK2B1.09000473
56AURKB1.06616193
57PKN11.05545517
58YES11.03210926
59CDK31.02734736
60DAPK11.01700815
61IRAK11.01635392
62PIM21.01028758
63GRK51.00879221
64RIPK40.99688978
65CDK80.99283125
66SRPK10.98632685
67PHKG10.96042696
68PHKG20.96042696
69TSSK60.94395481
70CAMK2A0.94184529
71FES0.92928905
72BRSK20.90868340
73ARAF0.88920500
74BUB10.87240658
75STK40.87090817
76PRKCE0.85405633
77AURKA0.83938164
78BRSK10.83673083
79CDK70.81720102
80CSNK2A20.80185083
81GRK10.79529484
82BRAF0.79229799
83SGK4940.78924070
84SGK2230.78924070
85CHEK10.77990131
86MAPKAPK30.77499110
87CAMK2D0.77004360
88EIF2AK20.76574447
89ILK0.75779814
90MINK10.75392677
91DYRK1A0.74884206
92DYRK20.73309115
93FGR0.69825859
94ABL20.69617235
95CSNK2A10.68851511
96PRKCG0.68368940
97KDR0.67727717
98CSNK1G30.65565948
99PLK30.65450778
100CLK10.65420794
101PASK0.65155836
102ATM0.64734405
103NTRK20.63253545
104SMG10.62959698
105RPS6KA40.61592562
106UHMK10.60872670
107CAMK2G0.60378262
108MAP3K130.60031414
109MST1R0.59882342
110EIF2AK30.57840935
111PAK40.57471728
112BLK0.56914467
113SGK20.56887916
114TNK20.56348495
115TXK0.54951007
116ADRBK10.53379098
117AKT20.53197093
118CDK40.52959304
119PINK10.52362075
120INSRR0.51805663
121MST40.51690110
122MAPK150.51171315
123ROCK20.47289206
124CDK50.46837661
125MAPK70.46074594
126LRRK20.45400791
127BRD40.45282629
128CSNK1A1L0.44493845
129CSNK1G20.44164286
130EEF2K0.43812346
131CSNK1E0.42742865
132PRKACA0.41047568
133ALK0.40307105
134CDK20.39734044
135CDK10.39301758
136PRKCI0.39230081
137CSNK1G10.39177016
138RPS6KA50.39138538
139CCNB10.38682501
140CAMK10.37986871
141MAP3K80.37282209
142WNK30.36683132
143MYLK0.35749165
144TESK20.34108380
145PRKD30.33650823
146LIMK10.33615404
147TEC0.32935230
148MAP3K60.32870290
149CSNK1A10.32232125
150EIF2AK10.31711651
151MAP2K40.31466175
152PRKG10.31073204
153PTK2B0.29761855
154TESK10.25310063
155PAK10.24414244
156DAPK30.24128828
157PRKDC0.23904983
158MAPK110.23562470
159MAP2K60.22327943
160CDK90.15428485
161PRKACB0.15028839

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.91995894
2DNA replication_Homo sapiens_hsa030303.53309133
3Nicotine addiction_Homo sapiens_hsa050333.42963877
4Parkinsons disease_Homo sapiens_hsa050123.03830172
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.63887984
6Alzheimers disease_Homo sapiens_hsa050102.47442320
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.43948558
8RNA polymerase_Homo sapiens_hsa030202.41583604
9One carbon pool by folate_Homo sapiens_hsa006702.41391657
10Huntingtons disease_Homo sapiens_hsa050162.35174133
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.28851607
12Collecting duct acid secretion_Homo sapiens_hsa049662.26004839
13Base excision repair_Homo sapiens_hsa034102.22365679
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.08624872
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.07267146
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.04745906
17Phototransduction_Homo sapiens_hsa047442.04737850
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.02974677
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.98363951
20Serotonergic synapse_Homo sapiens_hsa047261.97909662
21Taste transduction_Homo sapiens_hsa047421.96294302
22Morphine addiction_Homo sapiens_hsa050321.88444335
23Proteasome_Homo sapiens_hsa030501.87018352
24RNA transport_Homo sapiens_hsa030131.77494815
25Synaptic vesicle cycle_Homo sapiens_hsa047211.76178097
26GABAergic synapse_Homo sapiens_hsa047271.75958704
27Protein export_Homo sapiens_hsa030601.71094471
28Pyruvate metabolism_Homo sapiens_hsa006201.67385620
29Basal transcription factors_Homo sapiens_hsa030221.64128230
30Glutamatergic synapse_Homo sapiens_hsa047241.62545107
31Carbon metabolism_Homo sapiens_hsa012001.62418769
32Sulfur relay system_Homo sapiens_hsa041221.56589437
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.54265876
34Cardiac muscle contraction_Homo sapiens_hsa042601.52970438
35Biosynthesis of amino acids_Homo sapiens_hsa012301.52484904
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.51483480
37Fanconi anemia pathway_Homo sapiens_hsa034601.50216230
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.48227941
39Circadian entrainment_Homo sapiens_hsa047131.46276060
40Fatty acid elongation_Homo sapiens_hsa000621.46136520
41Amphetamine addiction_Homo sapiens_hsa050311.45078323
42Sphingolipid metabolism_Homo sapiens_hsa006001.39730795
43Ribosome_Homo sapiens_hsa030101.38429134
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32918029
45Propanoate metabolism_Homo sapiens_hsa006401.31408188
46Ether lipid metabolism_Homo sapiens_hsa005651.30731701
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.30542478
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27996859
49Rheumatoid arthritis_Homo sapiens_hsa053231.27864341
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.24417180
51Olfactory transduction_Homo sapiens_hsa047401.23128870
52Cell cycle_Homo sapiens_hsa041101.22353214
53Vibrio cholerae infection_Homo sapiens_hsa051101.20263492
54Long-term depression_Homo sapiens_hsa047301.16391091
55Homologous recombination_Homo sapiens_hsa034401.16372790
56Steroid biosynthesis_Homo sapiens_hsa001001.15227273
57Sulfur metabolism_Homo sapiens_hsa009201.13870961
58Cocaine addiction_Homo sapiens_hsa050301.11681283
59Glutathione metabolism_Homo sapiens_hsa004801.11464967
60Dopaminergic synapse_Homo sapiens_hsa047281.09930207
61Folate biosynthesis_Homo sapiens_hsa007901.09700386
62Purine metabolism_Homo sapiens_hsa002301.08947979
63Calcium signaling pathway_Homo sapiens_hsa040201.08112853
64Non-homologous end-joining_Homo sapiens_hsa034501.07943782
65Pyrimidine metabolism_Homo sapiens_hsa002401.07280848
66Pentose phosphate pathway_Homo sapiens_hsa000301.05524391
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04336425
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99831173
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97793459
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97693038
71Salivary secretion_Homo sapiens_hsa049700.97351684
72Arachidonic acid metabolism_Homo sapiens_hsa005900.95962556
73Fatty acid metabolism_Homo sapiens_hsa012120.93537132
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.93045505
75Fatty acid degradation_Homo sapiens_hsa000710.92630793
76Axon guidance_Homo sapiens_hsa043600.90979578
77Long-term potentiation_Homo sapiens_hsa047200.89077843
78Renin secretion_Homo sapiens_hsa049240.87552171
79Arginine and proline metabolism_Homo sapiens_hsa003300.87342879
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86790929
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86243851
82Selenocompound metabolism_Homo sapiens_hsa004500.85763254
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83214431
84Cholinergic synapse_Homo sapiens_hsa047250.81613707
85Insulin secretion_Homo sapiens_hsa049110.80939104
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80719801
87Autoimmune thyroid disease_Homo sapiens_hsa053200.80200818
88Regulation of autophagy_Homo sapiens_hsa041400.77927804
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77703327
90Peroxisome_Homo sapiens_hsa041460.77094395
91Arginine biosynthesis_Homo sapiens_hsa002200.76431080
92RNA degradation_Homo sapiens_hsa030180.75432538
93Nucleotide excision repair_Homo sapiens_hsa034200.75220319
94Spliceosome_Homo sapiens_hsa030400.74639694
95Fructose and mannose metabolism_Homo sapiens_hsa000510.73749876
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73375349
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.68736618
98N-Glycan biosynthesis_Homo sapiens_hsa005100.67060626
99Vitamin B6 metabolism_Homo sapiens_hsa007500.63468730
100Tryptophan metabolism_Homo sapiens_hsa003800.63188510
101Linoleic acid metabolism_Homo sapiens_hsa005910.60833083
102Circadian rhythm_Homo sapiens_hsa047100.60140015
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59604498
104Butanoate metabolism_Homo sapiens_hsa006500.59230461
105Galactose metabolism_Homo sapiens_hsa000520.58825901
106Oxytocin signaling pathway_Homo sapiens_hsa049210.57321786
107Mismatch repair_Homo sapiens_hsa034300.56711951
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52465197
109Phagosome_Homo sapiens_hsa041450.52417806
110Type I diabetes mellitus_Homo sapiens_hsa049400.51880234
111Cyanoamino acid metabolism_Homo sapiens_hsa004600.51641191
112cAMP signaling pathway_Homo sapiens_hsa040240.51594103
113African trypanosomiasis_Homo sapiens_hsa051430.51526118
114mRNA surveillance pathway_Homo sapiens_hsa030150.49352363
115Alcoholism_Homo sapiens_hsa050340.48894195
116Tyrosine metabolism_Homo sapiens_hsa003500.48685003
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47770604
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.47670300
119Metabolic pathways_Homo sapiens_hsa011000.47277214
120Allograft rejection_Homo sapiens_hsa053300.46763651
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46189457
122Gastric acid secretion_Homo sapiens_hsa049710.45894592
123Systemic lupus erythematosus_Homo sapiens_hsa053220.45617801
124Phenylalanine metabolism_Homo sapiens_hsa003600.45390757
125Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45386504
126Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43615985
127Oocyte meiosis_Homo sapiens_hsa041140.43079992
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42918102
129Ras signaling pathway_Homo sapiens_hsa040140.42400979
130p53 signaling pathway_Homo sapiens_hsa041150.40089972
131Fat digestion and absorption_Homo sapiens_hsa049750.39634777
132Ovarian steroidogenesis_Homo sapiens_hsa049130.38289422
133Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37548200
134Melanogenesis_Homo sapiens_hsa049160.37051495
135Asthma_Homo sapiens_hsa053100.36501151
136Vitamin digestion and absorption_Homo sapiens_hsa049770.36076217
137alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35698394
138Graft-versus-host disease_Homo sapiens_hsa053320.33336432
139Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33177276
140Primary bile acid biosynthesis_Homo sapiens_hsa001200.32732120
141Gap junction_Homo sapiens_hsa045400.32182595
142beta-Alanine metabolism_Homo sapiens_hsa004100.31957259
143GnRH signaling pathway_Homo sapiens_hsa049120.29759896
144Wnt signaling pathway_Homo sapiens_hsa043100.29712207
145Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29276596
146Starch and sucrose metabolism_Homo sapiens_hsa005000.27507926
147Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26501422
148MAPK signaling pathway_Homo sapiens_hsa040100.25461980
149Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25216470
150Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25165928
151Epstein-Barr virus infection_Homo sapiens_hsa051690.24457389
152Other glycan degradation_Homo sapiens_hsa005110.23321619
153Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.23285837
154Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.23179852
155Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.22648397
156Sphingolipid signaling pathway_Homo sapiens_hsa040710.22465234
157Melanoma_Homo sapiens_hsa052180.22370754
158Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22333075
159Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.19890689
160Steroid hormone biosynthesis_Homo sapiens_hsa001400.19093825
161Chemical carcinogenesis_Homo sapiens_hsa052040.18378604
162Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17078501
163Maturity onset diabetes of the young_Homo sapiens_hsa049500.16459865
164Lysine degradation_Homo sapiens_hsa003100.14805198
165Retinol metabolism_Homo sapiens_hsa008300.13261161
166Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.11782675

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