SFXN5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)5.15196874
2neurotransmitter-gated ion channel clustering (GO:0072578)4.80463411
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.75314694
4synaptic vesicle maturation (GO:0016188)4.72935713
5gamma-aminobutyric acid transport (GO:0015812)4.67540755
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.57069902
7vocalization behavior (GO:0071625)4.51453053
8cellular potassium ion homeostasis (GO:0030007)4.50240440
9neuronal action potential propagation (GO:0019227)4.46599167
10L-amino acid import (GO:0043092)4.42867179
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.35222481
12glutamate secretion (GO:0014047)4.27122570
13alanine transport (GO:0032328)4.21667472
14synaptic vesicle exocytosis (GO:0016079)4.19311245
15sodium ion export (GO:0071436)4.12562470
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.10547407
17regulation of synapse structural plasticity (GO:0051823)4.03222686
18regulation of glutamate receptor signaling pathway (GO:1900449)3.97884182
19amino acid import (GO:0043090)3.95468511
20response to auditory stimulus (GO:0010996)3.93904134
21negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.89681334
22membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.88438554
23neurotransmitter secretion (GO:0007269)3.87117261
24regulation of synaptic vesicle exocytosis (GO:2000300)3.85334981
25glutamate receptor signaling pathway (GO:0007215)3.82082450
26cell communication by electrical coupling (GO:0010644)3.80429336
27neuron cell-cell adhesion (GO:0007158)3.77346180
28positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.76633753
29synaptic transmission, glutamatergic (GO:0035249)3.76319360
30positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.75415304
31regulation of neuronal synaptic plasticity (GO:0048168)3.71813162
32exploration behavior (GO:0035640)3.71175864
33protein localization to synapse (GO:0035418)3.70486941
34proline transport (GO:0015824)3.70018274
35C4-dicarboxylate transport (GO:0015740)3.62991417
36postsynaptic membrane organization (GO:0001941)3.60225135
37auditory behavior (GO:0031223)3.56714175
38regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.54051909
39long-term memory (GO:0007616)3.53697070
40positive regulation of synapse maturation (GO:0090129)3.51056196
41synaptic vesicle docking involved in exocytosis (GO:0016081)3.50930517
42G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.50928532
43negative regulation of synaptic transmission, GABAergic (GO:0032229)3.48497346
44cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.48441329
45regulation of long-term neuronal synaptic plasticity (GO:0048169)3.48138041
46regulation of synaptic vesicle transport (GO:1902803)3.46299648
47positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.43221726
48membrane depolarization during action potential (GO:0086010)3.38242495
49transmission of nerve impulse (GO:0019226)3.37741735
50layer formation in cerebral cortex (GO:0021819)3.37047364
51negative regulation of astrocyte differentiation (GO:0048712)3.36455506
52neuron-neuron synaptic transmission (GO:0007270)3.34560978
53regulation of beta-amyloid formation (GO:1902003)3.33744736
54regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.33244897
55potassium ion import (GO:0010107)3.31475489
56presynaptic membrane assembly (GO:0097105)3.29245469
57regulation of synaptic transmission, glutamatergic (GO:0051966)3.28014534
58regulation of neurotransmitter uptake (GO:0051580)3.26086416
59neurotransmitter transport (GO:0006836)3.24345977
60neuronal ion channel clustering (GO:0045161)3.19148455
61long-term synaptic potentiation (GO:0060291)3.18787860
62regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.18340023
63cellular sodium ion homeostasis (GO:0006883)3.18081656
64dendritic spine morphogenesis (GO:0060997)3.16593691
65glycine transport (GO:0015816)3.16337132
66regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.15571344
67serotonin metabolic process (GO:0042428)3.14339120
68regulation of neurotransmitter levels (GO:0001505)3.11495527
69primary amino compound metabolic process (GO:1901160)3.10077105
70cerebellar granule cell differentiation (GO:0021707)3.09419597
71acidic amino acid transport (GO:0015800)3.08994009
72regulation of excitatory postsynaptic membrane potential (GO:0060079)3.08935390
73regulation of synapse maturation (GO:0090128)3.08230018
74positive regulation of membrane potential (GO:0045838)3.08176581
75synaptic vesicle endocytosis (GO:0048488)3.07659605
76positive regulation of potassium ion transmembrane transport (GO:1901381)3.05114232
77neuromuscular synaptic transmission (GO:0007274)3.04493965
78positive regulation of synaptic transmission, GABAergic (GO:0032230)3.04417091
79positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.04362342
80neurotransmitter uptake (GO:0001504)3.03331858
81membrane depolarization (GO:0051899)3.02691599
82regulation of synaptic plasticity (GO:0048167)3.00992677
83neuromuscular process controlling balance (GO:0050885)3.00310182
84potassium ion homeostasis (GO:0055075)2.99916620
85regulation of dendritic spine development (GO:0060998)2.99675710
86presynaptic membrane organization (GO:0097090)2.99606879
87neuromuscular process controlling posture (GO:0050884)2.99185992
88regulation of voltage-gated calcium channel activity (GO:1901385)2.96312320
89behavioral response to nicotine (GO:0035095)2.95252166
90chondroitin sulfate catabolic process (GO:0030207)2.93917202
91regulation of postsynaptic membrane potential (GO:0060078)2.89800809
92positive regulation of neurotransmitter transport (GO:0051590)2.89411174
93positive regulation of dendritic spine development (GO:0060999)2.85803089
94positive regulation of neurotransmitter secretion (GO:0001956)2.85311272
95prepulse inhibition (GO:0060134)2.84908849
96mechanosensory behavior (GO:0007638)2.84875387
97negative regulation of dendrite development (GO:2000171)2.84689604
98dendrite morphogenesis (GO:0048813)2.84059167
99regulation of amyloid precursor protein catabolic process (GO:1902991)2.83828004
100positive regulation of cellular amide metabolic process (GO:0034250)2.82619882
101synaptic transmission (GO:0007268)2.80375361
102L-glutamate transport (GO:0015813)2.78823393
103negative regulation of cytosolic calcium ion concentration (GO:0051481)2.78501049
104regulation of neurotransmitter secretion (GO:0046928)2.77394577
105cerebellar Purkinje cell differentiation (GO:0021702)2.76752005
106central nervous system myelination (GO:0022010)2.76200494
107axon ensheathment in central nervous system (GO:0032291)2.76200494
108startle response (GO:0001964)2.75943213
109cellular potassium ion transport (GO:0071804)2.75799250
110potassium ion transmembrane transport (GO:0071805)2.75799250
111gamma-aminobutyric acid signaling pathway (GO:0007214)2.74647818
112membrane repolarization (GO:0086009)2.74479817
113regulation of respiratory system process (GO:0044065)2.73275689
114regulation of vesicle fusion (GO:0031338)2.71993351
115cellular response to cholesterol (GO:0071397)2.71941270
116regulation of neurotransmitter transport (GO:0051588)2.71719466
117positive regulation of synaptic transmission (GO:0050806)2.71699829
118regulation of synaptic transmission (GO:0050804)2.68666704
119negative regulation of sodium ion transport (GO:0010766)2.68504552
120adult walking behavior (GO:0007628)2.68188243
121regulation of dendritic spine morphogenesis (GO:0061001)2.67703110
122cell differentiation in hindbrain (GO:0021533)2.67365784
123low-density lipoprotein particle remodeling (GO:0034374)2.66992709
124positive regulation of dendrite development (GO:1900006)2.66122706
125exogenous drug catabolic process (GO:0042738)2.65293720

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.48515591
2GBX2_23144817_ChIP-Seq_PC3_Human3.15596092
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12967281
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08507812
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00778295
6SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.74002840
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.73220618
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.73220618
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.66153964
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56914140
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55952178
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.54116198
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.46515524
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.46335312
15* REST_21632747_ChIP-Seq_MESCs_Mouse2.39020782
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.37381778
17DROSHA_22980978_ChIP-Seq_HELA_Human2.35448771
18AR_21572438_ChIP-Seq_LNCaP_Human2.23000084
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.22666875
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.22389314
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20429861
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.17660115
23* RARB_27405468_Chip-Seq_BRAIN_Mouse2.02370034
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.95726690
25REST_18959480_ChIP-ChIP_MESCs_Mouse1.91720601
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75464263
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.62740555
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57939025
29RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.56171775
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52490898
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50123839
32RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46252875
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45896625
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44874007
35SMAD4_21799915_ChIP-Seq_A2780_Human1.44150889
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41181938
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41156873
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38984590
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.37367283
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36854722
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35988818
42RING1B_27294783_Chip-Seq_ESCs_Mouse1.34504507
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33056056
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.32888499
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32664849
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.32403367
47P300_19829295_ChIP-Seq_ESCs_Human1.29180207
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23399403
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.23355237
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21681592
51AR_25329375_ChIP-Seq_VCAP_Human1.21564292
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20477929
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20477929
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17075479
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.16629260
56TAF15_26573619_Chip-Seq_HEK293_Human1.16286900
57DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13602670
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13275835
59AR_19668381_ChIP-Seq_PC3_Human1.12776529
60RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10361148
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10070486
62NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09698616
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08752016
64* SOX2_21211035_ChIP-Seq_LN229_Gbm1.08620851
65VDR_22108803_ChIP-Seq_LS180_Human1.08616930
66STAT3_23295773_ChIP-Seq_U87_Human1.08288172
67RXR_22108803_ChIP-Seq_LS180_Human1.06273679
68OCT4_19829295_ChIP-Seq_ESCs_Human1.05444218
69NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04668778
70CTCF_27219007_Chip-Seq_Bcells_Human1.04419090
71RING1B_27294783_Chip-Seq_NPCs_Mouse1.03578149
72MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03564337
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01478038
74PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01365016
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00783847
76TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00179578
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00098971
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99393223
79IGF1R_20145208_ChIP-Seq_DFB_Human0.98644761
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96814064
81BCAT_22108803_ChIP-Seq_LS180_Human0.95882472
82BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94981613
83TP53_20018659_ChIP-ChIP_R1E_Mouse0.94505533
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94418344
85SMAD4_21741376_ChIP-Seq_HESCs_Human0.94045449
86TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93782390
87ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93629006
88ER_23166858_ChIP-Seq_MCF-7_Human0.93288208
89RUNX2_22187159_ChIP-Seq_PCA_Human0.92912700
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92417821
91ARNT_22903824_ChIP-Seq_MCF-7_Human0.92250634
92TP53_18474530_ChIP-ChIP_U2OS_Human0.92066687
93TCF4_23295773_ChIP-Seq_U87_Human0.91566902
94ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90219294
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88953183
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88689359
97KLF4_19829295_ChIP-Seq_ESCs_Human0.88180460
98SMAD3_21741376_ChIP-Seq_HESCs_Human0.87852287
99NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.87277840
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86763328
101P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86254701
102* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86239825
103* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.86069456
104SMAD3_21741376_ChIP-Seq_ESCs_Human0.85812878
105TP53_16413492_ChIP-PET_HCT116_Human0.84728815
106AHR_22903824_ChIP-Seq_MCF-7_Human0.84725839
107* KDM2B_26808549_Chip-Seq_K562_Human0.84542079
108GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83985813
109GATA1_26923725_Chip-Seq_HPCs_Mouse0.83825860
110RNF2_27304074_Chip-Seq_NSC_Mouse0.83786812
111PRDM14_20953172_ChIP-Seq_ESCs_Human0.82742191
112* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.82062377
113ERA_21632823_ChIP-Seq_H3396_Human0.81735767
114ZNF274_21170338_ChIP-Seq_K562_Hela0.81371132
115PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80079097
116MYC_19829295_ChIP-Seq_ESCs_Human0.80061803
117SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79251532
118NANOG_18555785_Chip-Seq_ESCs_Mouse0.79047803
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.78514989
120BMI1_23680149_ChIP-Seq_NPCS_Mouse0.78146748
121OCT4_20526341_ChIP-Seq_ESCs_Human0.77441914
122NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.77239590
123* CBP_20019798_ChIP-Seq_JUKART_Human0.76954292
124* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.76954292
125FLI1_21867929_ChIP-Seq_TH2_Mouse0.76001582
126KDM2B_26808549_Chip-Seq_REH_Human0.75931540

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.49109861
2MP0003880_abnormal_central_pattern3.77629215
3MP0003635_abnormal_synaptic_transmissio3.68156718
4MP0009745_abnormal_behavioral_response3.15525958
5MP0009046_muscle_twitch3.15448096
6MP0004270_analgesia3.08269621
7MP0002064_seizures2.97335294
8MP0001486_abnormal_startle_reflex2.88656522
9MP0002063_abnormal_learning/memory/cond2.85728456
10MP0004858_abnormal_nervous_system2.58206390
11MP0005646_abnormal_pituitary_gland2.56779919
12MP0002572_abnormal_emotion/affect_behav2.56128727
13MP0001968_abnormal_touch/_nociception2.54925471
14MP0005423_abnormal_somatic_nervous2.51460752
15MP0003690_abnormal_glial_cell2.48387540
16MP0003329_amyloid_beta_deposits2.46888559
17MP0002272_abnormal_nervous_system2.42919959
18MP0002734_abnormal_mechanical_nocicepti2.28722808
19MP0008569_lethality_at_weaning2.27552402
20MP0003136_yellow_coat_color2.10697113
21MP0002822_catalepsy2.09934331
22MP0001501_abnormal_sleep_pattern2.05376171
23MP0004885_abnormal_endolymph2.02976777
24MP0001440_abnormal_grooming_behavior2.02207363
25MP0002736_abnormal_nociception_after2.02065918
26MP0002067_abnormal_sensory_capabilities1.98209501
27MP0009780_abnormal_chondrocyte_physiolo1.97993277
28MP0002733_abnormal_thermal_nociception1.92085732
29MP0002557_abnormal_social/conspecific_i1.82754064
30MP0002735_abnormal_chemical_nociception1.82018949
31MP0001970_abnormal_pain_threshold1.81056384
32MP0001984_abnormal_olfaction1.80217084
33MP0001502_abnormal_circadian_rhythm1.78151047
34MP0000778_abnormal_nervous_system1.62383822
35MP0003633_abnormal_nervous_system1.62119121
36MP0005645_abnormal_hypothalamus_physiol1.59534195
37MP0004142_abnormal_muscle_tone1.58634821
38MP0002909_abnormal_adrenal_gland1.54812075
39MP0002653_abnormal_ependyma_morphology1.54347906
40MP0003195_calcinosis1.52714579
41MP0008875_abnormal_xenobiotic_pharmacok1.52466982
42MP0003787_abnormal_imprinting1.52290954
43MP0003075_altered_response_to1.50176569
44MP0002638_abnormal_pupillary_reflex1.45849131
45MP0005386_behavior/neurological_phenoty1.43669847
46MP0004924_abnormal_behavior1.43669847
47MP0003634_abnormal_glial_cell1.40006852
48MP0003631_nervous_system_phenotype1.39255311
49MP0000955_abnormal_spinal_cord1.37753870
50MP0002184_abnormal_innervation1.36339456
51MP0002882_abnormal_neuron_morphology1.31685611
52MP0000604_amyloidosis1.30269238
53MP0002066_abnormal_motor_capabilities/c1.29867782
54MP0005551_abnormal_eye_electrophysiolog1.24038474
55MP0004811_abnormal_neuron_physiology1.23206611
56MP0000569_abnormal_digit_pigmentation1.19999274
57MP0003632_abnormal_nervous_system1.19043302
58MP0004147_increased_porphyrin_level1.18496000
59MP0006276_abnormal_autonomic_nervous1.17576758
60MP0000920_abnormal_myelination1.15804161
61MP0003879_abnormal_hair_cell1.14645038
62MP0005167_abnormal_blood-brain_barrier1.14639950
63MP0002254_reproductive_system_inflammat1.14373805
64MP0001485_abnormal_pinna_reflex1.11374376
65MP0003122_maternal_imprinting1.10624775
66MP0008877_abnormal_DNA_methylation1.09910279
67MP0001905_abnormal_dopamine_level1.09188950
68MP0005365_abnormal_bile_salt1.08391975
69MP0005085_abnormal_gallbladder_physiolo1.08359055
70MP0002229_neurodegeneration1.07853008
71MP0001963_abnormal_hearing_physiology1.05240868
72MP0005171_absent_coat_pigmentation1.04616984
73MP0001177_atelectasis1.00623080
74MP0002152_abnormal_brain_morphology1.00119871
75MP0003011_delayed_dark_adaptation0.99712504
76MP0004742_abnormal_vestibular_system0.99174950
77MP0004133_heterotaxia0.97093882
78MP0005535_abnormal_body_temperature0.94404090
79MP0005409_darkened_coat_color0.93832465
80MP0002090_abnormal_vision0.93198258
81MP0005377_hearing/vestibular/ear_phenot0.90931034
82MP0003878_abnormal_ear_physiology0.90931034
83MP0008874_decreased_physiological_sensi0.87879276
84MP0002069_abnormal_eating/drinking_beha0.86378571
85MP0001188_hyperpigmentation0.85731753
86MP0008872_abnormal_physiological_respon0.85358271
87MP0002876_abnormal_thyroid_physiology0.81649326
88MP0001529_abnormal_vocalization0.81545580
89MP0003183_abnormal_peptide_metabolism0.81503869
90MP0000026_abnormal_inner_ear0.79791148
91MP0003283_abnormal_digestive_organ0.79117527
92MP0005253_abnormal_eye_physiology0.78612777
93MP0003137_abnormal_impulse_conducting0.77662498
94MP0002752_abnormal_somatic_nervous0.76968755
95MP0003172_abnormal_lysosome_physiology0.76155490
96MP0005332_abnormal_amino_acid0.71883871
97MP0003252_abnormal_bile_duct0.71349219
98MP0006292_abnormal_olfactory_placode0.71132407
99MP0005499_abnormal_olfactory_system0.70716070
100MP0005394_taste/olfaction_phenotype0.70716070
101MP0001986_abnormal_taste_sensitivity0.70240625
102MP0005174_abnormal_tail_pigmentation0.69806028
103MP0002139_abnormal_hepatobiliary_system0.68646838
104MP0000631_abnormal_neuroendocrine_gland0.67986862
105MP0005595_abnormal_vascular_smooth0.67030293
106MP0000566_synostosis0.66079789
107MP0004043_abnormal_pH_regulation0.65903286
108MP0000751_myopathy0.65369012
109MP0010329_abnormal_lipoprotein_level0.64545932
110MP0006072_abnormal_retinal_apoptosis0.63551639
111MP0001664_abnormal_digestion0.62534483
112MP0004130_abnormal_muscle_cell0.62506633
113MP0009840_abnormal_foam_cell0.60813918
114MP0004215_abnormal_myocardial_fiber0.60470930
115MP0003638_abnormal_response/metabolism_0.58316832
116MP0005448_abnormal_energy_balance0.57695513
117MP0005379_endocrine/exocrine_gland_phen0.57656015
118MP0010386_abnormal_urinary_bladder0.57549621
119MP0009384_cardiac_valve_regurgitation0.57385253
120MP0005166_decreased_susceptibility_to0.55076346
121MP0004085_abnormal_heartbeat0.54630231

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.93505520
2Myokymia (HP:0002411)6.45789181
3Megalencephaly (HP:0001355)5.26624479
4Action tremor (HP:0002345)4.76800291
5Aplasia involving bones of the extremities (HP:0009825)4.70051515
6Aplasia involving bones of the upper limbs (HP:0009823)4.70051515
7Aplasia of the phalanges of the hand (HP:0009802)4.70051515
8Progressive cerebellar ataxia (HP:0002073)4.61882950
9Focal seizures (HP:0007359)4.60782003
10Epileptic encephalopathy (HP:0200134)4.27030346
11Visual hallucinations (HP:0002367)3.82843587
12Febrile seizures (HP:0002373)3.75242110
13Dysdiadochokinesis (HP:0002075)3.72208919
14Neurofibrillary tangles (HP:0002185)3.72142064
15Hemiplegia (HP:0002301)3.67119254
16Hemiparesis (HP:0001269)3.57823444
17Generalized tonic-clonic seizures (HP:0002069)3.52892740
18Diplopia (HP:0000651)3.48578760
19Abnormality of binocular vision (HP:0011514)3.48578760
20Atonic seizures (HP:0010819)3.47871171
21Status epilepticus (HP:0002133)3.31060059
22Abnormal eating behavior (HP:0100738)3.30879465
23Gaze-evoked nystagmus (HP:0000640)3.27970049
24Supranuclear gaze palsy (HP:0000605)3.26591676
25Absence seizures (HP:0002121)3.19164905
26Depression (HP:0000716)3.12201125
27Anxiety (HP:0000739)3.06225397
28Dialeptic seizures (HP:0011146)3.00505756
29Postural instability (HP:0002172)2.98987281
30Scanning speech (HP:0002168)2.94973247
31Dysmetria (HP:0001310)2.92975722
32Hyperventilation (HP:0002883)2.84006463
33Truncal ataxia (HP:0002078)2.83716828
34Cerebral inclusion bodies (HP:0100314)2.76145304
35Ankle clonus (HP:0011448)2.71551045
36Split foot (HP:0001839)2.71223499
37Intention tremor (HP:0002080)2.68943720
38Impaired vibration sensation in the lower limbs (HP:0002166)2.63960712
39Urinary bladder sphincter dysfunction (HP:0002839)2.54164433
40Polyphagia (HP:0002591)2.51321681
41Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.50558051
42Broad-based gait (HP:0002136)2.49652332
43Genetic anticipation (HP:0003743)2.49508812
44Limb dystonia (HP:0002451)2.46351004
45Polydipsia (HP:0001959)2.40197305
46Abnormal drinking behavior (HP:0030082)2.40197305
47Hypomagnesemia (HP:0002917)2.34371223
48Decreased central vision (HP:0007663)2.31153210
49Clumsiness (HP:0002312)2.29687288
50Bradykinesia (HP:0002067)2.29437877
51Humeroradial synostosis (HP:0003041)2.29266935
52Synostosis involving the elbow (HP:0003938)2.29266935
53Impaired vibratory sensation (HP:0002495)2.28922183
54Poor eye contact (HP:0000817)2.27339949
55Torticollis (HP:0000473)2.25582855
56Abnormal social behavior (HP:0012433)2.19909107
57Impaired social interactions (HP:0000735)2.19909107
58Clonus (HP:0002169)2.19639166
59Polyuria (HP:0000103)2.19263744
60Spastic gait (HP:0002064)2.17123526
61Abnormality of the axillary hair (HP:0100134)2.17108189
62Abnormality of secondary sexual hair (HP:0009888)2.17108189
63True hermaphroditism (HP:0010459)2.15767340
64Blue irides (HP:0000635)2.15314826
65Focal dystonia (HP:0004373)2.13533381
66Amblyopia (HP:0000646)2.12650887
67Congenital stationary night blindness (HP:0007642)2.12581363
68Limb ataxia (HP:0002070)2.10783520
69Impaired smooth pursuit (HP:0007772)2.09274387
70Papilledema (HP:0001085)2.06229940
71Type II lissencephaly (HP:0007260)2.05986086
72Hypoplastic left heart (HP:0004383)2.05417926
73Abnormal urine output (HP:0012590)2.05083713
74Rigidity (HP:0002063)2.05038487
75Sleep apnea (HP:0010535)2.04567484
76Stereotypic behavior (HP:0000733)2.03689777
77Agitation (HP:0000713)2.03057532
78Pancreatic cysts (HP:0001737)2.01722512
79Protruding tongue (HP:0010808)2.01448059
80Abnormality of saccadic eye movements (HP:0000570)2.01366189
81Absent speech (HP:0001344)2.00553520
82Anomalous pulmonary venous return (HP:0010772)2.00179160
83Lower limb muscle weakness (HP:0007340)1.99985201
84Metabolic alkalosis (HP:0200114)1.99955132
85Abnormality of ocular smooth pursuit (HP:0000617)1.99889534
86Generalized myoclonic seizures (HP:0002123)1.99423709
87Pheochromocytoma (HP:0002666)1.99376802
88Epileptiform EEG discharges (HP:0011182)1.97968855
89Morphological abnormality of the pyramidal tract (HP:0002062)1.96688791
90Inability to walk (HP:0002540)1.96315642
91Dysmetric saccades (HP:0000641)1.95518263
92Hyperglycinuria (HP:0003108)1.93194719
93Increased neuronal autofluorescent lipopigment (HP:0002074)1.92838075
94EEG with generalized epileptiform discharges (HP:0011198)1.92397963
95Abnormality of midbrain morphology (HP:0002418)1.91057474
96Molar tooth sign on MRI (HP:0002419)1.91057474
97Psychosis (HP:0000709)1.90830579
98Spastic tetraparesis (HP:0001285)1.90791007
99Gait ataxia (HP:0002066)1.89835059
100Hypsarrhythmia (HP:0002521)1.89675287
101Pancreatic fibrosis (HP:0100732)1.89277156
102Abnormality of magnesium homeostasis (HP:0004921)1.86827507
103Narrow nasal bridge (HP:0000446)1.86094735
104Craniofacial dystonia (HP:0012179)1.84928712
105Progressive inability to walk (HP:0002505)1.84777791
106Severe global developmental delay (HP:0011344)1.84407861
107Confusion (HP:0001289)1.81040440
108Postural tremor (HP:0002174)1.80326928
109Alkalosis (HP:0001948)1.78716581
110Increased circulating renin level (HP:0000848)1.78174899
111Akinesia (HP:0002304)1.77970065
112Mutism (HP:0002300)1.77467877
113Cerebral hypomyelination (HP:0006808)1.77359996
114Delusions (HP:0000746)1.77307635
115Urinary urgency (HP:0000012)1.76969379
116Long nose (HP:0003189)1.76595734
117Drooling (HP:0002307)1.75342060
118Excessive salivation (HP:0003781)1.75342060
119Dementia (HP:0000726)1.75270664
120Tetraplegia (HP:0002445)1.75139739
121Attenuation of retinal blood vessels (HP:0007843)1.74644032
122Morphological abnormality of the inner ear (HP:0011390)1.74567112
123Nephronophthisis (HP:0000090)1.74324020
124Dyskinesia (HP:0100660)1.74127353
125Abnormality of glycine metabolism (HP:0010895)1.73628403
126Abnormality of serine family amino acid metabolism (HP:0010894)1.73628403
127Hypokalemic alkalosis (HP:0001949)1.72992525
128Obstructive sleep apnea (HP:0002870)1.71415673
129Annular pancreas (HP:0001734)1.71258947
130Abolished electroretinogram (ERG) (HP:0000550)1.70877979
131Abnormality of the diencephalon (HP:0010662)1.69845698
132Complement deficiency (HP:0004431)1.69418437
133Mixed hearing impairment (HP:0000410)1.69402918
134Hyperglycinemia (HP:0002154)1.69363965
135Intellectual disability, severe (HP:0010864)1.69153375
136Ventricular fibrillation (HP:0001663)1.68538128
137Fetal akinesia sequence (HP:0001989)1.67721194
138Neuronal loss in central nervous system (HP:0002529)1.66257215
139Peripheral hypomyelination (HP:0007182)1.64089770
140Neuroendocrine neoplasm (HP:0100634)1.62555250
141Bronchomalacia (HP:0002780)1.62398617

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.68005695
2NTRK33.61105426
3TNIK3.24761016
4NTRK23.07835189
5CASK3.05650022
6LMTK22.93365925
7FRK2.89735987
8PRKD32.69916781
9MAP2K72.34276629
10MAP3K92.33621507
11MINK12.27124096
12PHKG12.25643270
13PHKG22.25643270
14PRPF4B2.16402197
15MAP3K42.12451421
16DAPK22.02136093
17MARK12.01231836
18MAPK131.79728335
19SGK21.79341834
20CAMKK11.72701354
21PAK61.70624924
22SGK2231.70135189
23SGK4941.70135189
24PINK11.55963365
25MUSK1.55019982
26MAP2K41.52515021
27NTRK11.49399552
28SGK31.44475175
29PRKCG1.40085314
30WNK41.36950981
31CDK51.36458297
32FES1.30978185
33STK381.29447373
34ADRBK21.26662534
35RIPK41.25200258
36CAMKK21.23614325
37CDK191.12400479
38PRKCH1.10888504
39KSR21.07972059
40MAP2K61.04843809
41MAP3K121.04841910
42GRK50.99351790
43CAMK10.95784496
44MKNK20.93330945
45CAMK2A0.93095840
46TNK20.87755846
47MAPK120.87308704
48TYRO30.87271054
49MAP3K130.85856803
50SIK20.85675494
51INSRR0.84288276
52TLK10.81552439
53SIK10.81279891
54NEK60.81087899
55PLK20.78739093
56ARAF0.77436610
57GRK10.76796434
58KSR10.76454122
59STK390.75933233
60DAPK10.75788914
61OXSR10.75727958
62DYRK1A0.75115722
63CAMK2B0.75001104
64MAP3K110.74997826
65SGK10.74896082
66ERBB20.74247160
67UHMK10.74096430
68BMPR20.72497154
69CAMK2G0.71644071
70FGR0.70856702
71CDK150.69070991
72PIK3CA0.69041865
73STK110.68304498
74CDK180.67980949
75PRKCE0.66337994
76CDK140.65722939
77CAMK1D0.64919808
78WNK30.62168645
79CDK11A0.59002748
80PTK2B0.58275250
81TAOK30.57793430
82MAP3K20.56954937
83ZAK0.55278915
84BMPR1B0.53930248
85PDPK10.53267753
86PRKD20.52662514
87IRAK20.52126256
88MAP4K20.51908923
89PAK30.51494301
90WNK10.51345448
91RPS6KA30.50215786
92ADRBK10.49640757
93RIPK10.49392127
94PDK10.48923909
95TRIB30.48616359
96PRKCZ0.48062522
97DYRK20.47817613
98ROCK20.47780021
99ROCK10.45876611
100MARK20.45697964
101CAMK2D0.45537659
102RET0.45501045
103CAMK40.45202808
104MAP3K70.45192380
105CSNK1G20.44693331
106PNCK0.43138965
107MAPK70.43124149
108CSNK1D0.42091506
109CDC42BPA0.41943548
110FGFR20.41759325
111PRKACA0.41110579
112PRKCA0.41002342
113MAPK150.40489631
114PRKACG0.40067555
115MAPKAPK50.39604409
116FYN0.39461643
117BMX0.38359301
118MAPK80.38210121
119BRSK10.36842102
120PRKG10.36387029
121PRKCQ0.35771774
122ALK0.35077602
123TXK0.34538628
124CAMK1G0.34240955
125MAPK100.34071305
126PKN10.28907898
127PRKCB0.28847171

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.49723629
2Nicotine addiction_Homo sapiens_hsa050333.35038477
3GABAergic synapse_Homo sapiens_hsa047272.57118032
4Synaptic vesicle cycle_Homo sapiens_hsa047212.49852117
5Glutamatergic synapse_Homo sapiens_hsa047242.47610768
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.44498283
7Olfactory transduction_Homo sapiens_hsa047402.26608758
8Circadian entrainment_Homo sapiens_hsa047132.24008933
9Morphine addiction_Homo sapiens_hsa050322.18694506
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.18093053
11Fatty acid biosynthesis_Homo sapiens_hsa000612.14137575
12Salivary secretion_Homo sapiens_hsa049702.00774299
13Long-term potentiation_Homo sapiens_hsa047201.89949649
14Insulin secretion_Homo sapiens_hsa049111.83650379
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.81767364
16Gastric acid secretion_Homo sapiens_hsa049711.75572512
17Amphetamine addiction_Homo sapiens_hsa050311.73473708
18Vitamin B6 metabolism_Homo sapiens_hsa007501.71239005
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.63413854
20Histidine metabolism_Homo sapiens_hsa003401.57150274
21Dopaminergic synapse_Homo sapiens_hsa047281.50979597
22Taste transduction_Homo sapiens_hsa047421.50568763
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.45462558
24Cholinergic synapse_Homo sapiens_hsa047251.44799371
25Cocaine addiction_Homo sapiens_hsa050301.41586605
26Calcium signaling pathway_Homo sapiens_hsa040201.39167633
27Long-term depression_Homo sapiens_hsa047301.29023108
28Caffeine metabolism_Homo sapiens_hsa002321.27675770
29Linoleic acid metabolism_Homo sapiens_hsa005911.24236345
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23045022
31Bile secretion_Homo sapiens_hsa049761.22765669
32Serotonergic synapse_Homo sapiens_hsa047261.22351425
33Fatty acid metabolism_Homo sapiens_hsa012121.20133963
34Renin secretion_Homo sapiens_hsa049241.19820633
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17280675
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16689854
37cAMP signaling pathway_Homo sapiens_hsa040241.14455192
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12664982
39ABC transporters_Homo sapiens_hsa020101.12299814
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12062971
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11854769
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11241247
43Arginine biosynthesis_Homo sapiens_hsa002201.10158419
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06109146
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04508886
46Tryptophan metabolism_Homo sapiens_hsa003801.03292295
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01611852
48Oxytocin signaling pathway_Homo sapiens_hsa049211.01326730
49Butanoate metabolism_Homo sapiens_hsa006500.98316882
50Gap junction_Homo sapiens_hsa045400.94749969
51GnRH signaling pathway_Homo sapiens_hsa049120.94132335
52Melanogenesis_Homo sapiens_hsa049160.89940229
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88938498
54Complement and coagulation cascades_Homo sapiens_hsa046100.88098937
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87755434
56Fatty acid degradation_Homo sapiens_hsa000710.87571402
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83528419
58PPAR signaling pathway_Homo sapiens_hsa033200.82537181
59Circadian rhythm_Homo sapiens_hsa047100.82277479
60Pancreatic secretion_Homo sapiens_hsa049720.80733503
61Chemical carcinogenesis_Homo sapiens_hsa052040.80571585
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78971880
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.78539576
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.77968106
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.76915981
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75407193
67Collecting duct acid secretion_Homo sapiens_hsa049660.74602325
68Retinol metabolism_Homo sapiens_hsa008300.72500389
69Dorso-ventral axis formation_Homo sapiens_hsa043200.71096016
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70739995
71Thyroid hormone synthesis_Homo sapiens_hsa049180.70398850
72Propanoate metabolism_Homo sapiens_hsa006400.66895977
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66848625
74Arginine and proline metabolism_Homo sapiens_hsa003300.66308229
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66174573
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66120394
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65284106
78Axon guidance_Homo sapiens_hsa043600.65180300
79Type II diabetes mellitus_Homo sapiens_hsa049300.64926727
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64250477
81Phototransduction_Homo sapiens_hsa047440.62270896
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62206794
83Estrogen signaling pathway_Homo sapiens_hsa049150.62143137
84Cardiac muscle contraction_Homo sapiens_hsa042600.59878842
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57361989
86ErbB signaling pathway_Homo sapiens_hsa040120.57325143
87Glioma_Homo sapiens_hsa052140.57133071
88Ether lipid metabolism_Homo sapiens_hsa005650.57021615
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53173446
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.52900534
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52878575
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.50705899
93Glucagon signaling pathway_Homo sapiens_hsa049220.49728579
94Mineral absorption_Homo sapiens_hsa049780.49134297
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48085338
96Fatty acid elongation_Homo sapiens_hsa000620.47978206
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47042531
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46067919
99Glycerolipid metabolism_Homo sapiens_hsa005610.45354406
100African trypanosomiasis_Homo sapiens_hsa051430.43318447
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42928282
102Arachidonic acid metabolism_Homo sapiens_hsa005900.41507993
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41458517
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40625468
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.40554904
106Choline metabolism in cancer_Homo sapiens_hsa052310.38717238
107Peroxisome_Homo sapiens_hsa041460.37419558
108Maturity onset diabetes of the young_Homo sapiens_hsa049500.36927118
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36112226
110Prion diseases_Homo sapiens_hsa050200.34019797
111Rap1 signaling pathway_Homo sapiens_hsa040150.33902259
112Steroid biosynthesis_Homo sapiens_hsa001000.31826613
113Ovarian steroidogenesis_Homo sapiens_hsa049130.31751167
114Dilated cardiomyopathy_Homo sapiens_hsa054140.31707750
115Type I diabetes mellitus_Homo sapiens_hsa049400.30923580
116beta-Alanine metabolism_Homo sapiens_hsa004100.30120125
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.30033551
118MAPK signaling pathway_Homo sapiens_hsa040100.29541864
119Ras signaling pathway_Homo sapiens_hsa040140.29128502
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.26841422
121Inositol phosphate metabolism_Homo sapiens_hsa005620.26333074

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