SGCA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)9.15352507
2muscle filament sliding (GO:0030049)8.98708225
3actin-myosin filament sliding (GO:0033275)8.98708225
4regulation of skeletal muscle contraction (GO:0014819)7.74837382
5cardiac myofibril assembly (GO:0055003)7.72530621
6myofibril assembly (GO:0030239)7.69080860
7actin-mediated cell contraction (GO:0070252)7.41675746
8negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.36856473
9positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)7.09179683
10plasma membrane repair (GO:0001778)7.06505896
11sarcoplasmic reticulum calcium ion transport (GO:0070296)6.71507879
12negative regulation of potassium ion transmembrane transport (GO:1901380)6.54720366
13skeletal muscle fiber development (GO:0048741)6.53914489
14regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.47047544
15cardiac muscle contraction (GO:0060048)6.33032739
16tricarboxylic acid cycle (GO:0006099)6.03901139
17striated muscle contraction (GO:0006941)5.96272202
18cardiac muscle cell development (GO:0055013)5.89922595
19skeletal muscle contraction (GO:0003009)5.89456605
20myotube cell development (GO:0014904)5.88238324
21actomyosin structure organization (GO:0031032)5.83943355
22regulation of relaxation of muscle (GO:1901077)5.81880795
23regulation of actin filament-based movement (GO:1903115)5.75186031
24regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.68040073
25actin filament-based movement (GO:0030048)5.55532122
26cardiac cell development (GO:0055006)5.53235361
27carnitine shuttle (GO:0006853)5.51114589
28regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.48756610
29regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.46179197
30response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.37451333
31regulation of cell communication by electrical coupling (GO:0010649)5.36872515
32regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.26942059
33muscle cell fate commitment (GO:0042693)5.18383437
34cardiac muscle tissue morphogenesis (GO:0055008)5.08924766
35skeletal muscle tissue development (GO:0007519)5.05844109
36adult heart development (GO:0007512)5.02822620
37regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.99554050
38cardiac muscle hypertrophy (GO:0003300)4.98159167
39regulation of acyl-CoA biosynthetic process (GO:0050812)4.96615636
40positive regulation of myotube differentiation (GO:0010831)4.93398839
41muscle cell cellular homeostasis (GO:0046716)4.93254920
42heart process (GO:0003015)4.85372896
43heart contraction (GO:0060047)4.85372896
44ventricular cardiac muscle cell action potential (GO:0086005)4.83464308
45striated muscle hypertrophy (GO:0014897)4.82211374
46regulation of striated muscle contraction (GO:0006942)4.80504001
47creatine metabolic process (GO:0006600)4.73882134
48skeletal muscle adaptation (GO:0043501)4.73611366
49muscle tissue morphogenesis (GO:0060415)4.72220021
50fatty acid transmembrane transport (GO:1902001)4.70031405
51regulation of sarcomere organization (GO:0060297)4.69163805
52heart trabecula formation (GO:0060347)4.66355592
53ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.64640697
54regulation of coenzyme metabolic process (GO:0051196)4.51605271
55regulation of cofactor metabolic process (GO:0051193)4.51605271
56glycogen biosynthetic process (GO:0005978)4.45821739
57glucan biosynthetic process (GO:0009250)4.45821739
58skeletal muscle tissue regeneration (GO:0043403)4.44251812
59bundle of His cell to Purkinje myocyte communication (GO:0086069)4.42811526
60response to inactivity (GO:0014854)4.38767366
61regulation of membrane repolarization (GO:0060306)4.31157511
62muscle hypertrophy (GO:0014896)4.25573251
63* muscle contraction (GO:0006936)4.24575723
64muscle atrophy (GO:0014889)4.20591059
65myoblast fusion (GO:0007520)4.20052002
66carnitine transmembrane transport (GO:1902603)4.14298437
67striated muscle adaptation (GO:0014888)4.12695230
68* muscle organ development (GO:0007517)4.07188892
69cellular polysaccharide catabolic process (GO:0044247)4.07179795
70* muscle structure development (GO:0061061)4.04853385
71striated muscle cell development (GO:0055002)3.95952521
72positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.95101290
73mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.92422347
74* muscle system process (GO:0003012)3.92313937
75regulation of the force of heart contraction (GO:0002026)3.92302687
76striated muscle atrophy (GO:0014891)3.87014705
77NADH metabolic process (GO:0006734)3.85350295
78cardiac muscle hypertrophy in response to stress (GO:0014898)3.85055120
79muscle hypertrophy in response to stress (GO:0003299)3.85055120
80cardiac muscle adaptation (GO:0014887)3.85055120
81mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.81044021
82positive regulation of myoblast differentiation (GO:0045663)3.80095993
832-oxoglutarate metabolic process (GO:0006103)3.78615235
84amino-acid betaine transport (GO:0015838)3.77692634
85carnitine transport (GO:0015879)3.77692634
86response to muscle activity (GO:0014850)3.76259237
87glycogen catabolic process (GO:0005980)3.73518213
88regulation of sequestering of triglyceride (GO:0010889)3.72513322
89syncytium formation by plasma membrane fusion (GO:0000768)3.67765629
90cell communication involved in cardiac conduction (GO:0086065)3.67713320
91polysaccharide catabolic process (GO:0000272)3.66240082
92regulation of sulfur metabolic process (GO:0042762)3.65338167
93respiratory electron transport chain (GO:0022904)3.64650231
94regulation of myoblast differentiation (GO:0045661)3.63125978
95ATP synthesis coupled proton transport (GO:0015986)3.62292942
96energy coupled proton transport, down electrochemical gradient (GO:0015985)3.62292942
97regulation of ATPase activity (GO:0043462)3.61964203
98regulation of ATP catabolic process (GO:1903289)3.61964203
99negative regulation of protein localization to cell surface (GO:2000009)3.61942807
100muscle fiber development (GO:0048747)3.59251854
101response to activity (GO:0014823)3.58753835
102regulation of cardiac muscle cell contraction (GO:0086004)3.58706606
103negative regulation of potassium ion transport (GO:0043267)3.58228766
104regulation of calcium ion transmembrane transport (GO:1903169)3.57292852
105regulation of calcium ion transmembrane transporter activity (GO:1901019)3.57292852
106striated muscle tissue development (GO:0014706)3.57091192
107oxidative phosphorylation (GO:0006119)3.56457091
108cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.55762634
109regulation of cardiac muscle contraction (GO:0055117)3.54173077
110electron transport chain (GO:0022900)3.53459203
111positive regulation of cation channel activity (GO:2001259)3.52931365
112regulation of heart rate (GO:0002027)3.50778701
113cardiac muscle cell action potential involved in contraction (GO:0086002)3.50229374
114negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.48356454
115negative regulation of calcium ion transmembrane transport (GO:1903170)3.48356454
116glucan catabolic process (GO:0009251)3.48083278
117cardiac muscle cell action potential (GO:0086001)3.47832831
118regulation of muscle system process (GO:0090257)3.45960626
119pyrimidine ribonucleoside catabolic process (GO:0046133)3.45423881
120muscle adaptation (GO:0043500)3.43969286
121myotube differentiation (GO:0014902)3.43173766
122glycogen metabolic process (GO:0005977)3.42830890
123negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.42426080
124negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.41433191
125muscle organ morphogenesis (GO:0048644)3.40401524
126regulation of muscle contraction (GO:0006937)3.40166669
127muscle cell development (GO:0055001)3.39790792
128positive regulation of heart rate (GO:0010460)3.36444403
129regulation of skeletal muscle cell differentiation (GO:2001014)3.36320297
130glucan metabolic process (GO:0044042)3.35754172
131cellular glucan metabolic process (GO:0006073)3.35754172
132gluconeogenesis (GO:0006094)3.31178250
133regulation of myotube differentiation (GO:0010830)3.28709746
134fructose metabolic process (GO:0006000)3.22512627

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.27709290
2EP300_21415370_ChIP-Seq_HL-1_Mouse4.20992222
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.20464671
4TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.01060686
5TBX20_22328084_ChIP-Seq_HEART_Mouse3.97427608
6TBX20_22080862_ChIP-Seq_HEART_Mouse3.97427608
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.55151842
8ESR1_20079471_ChIP-ChIP_T-47D_Human3.38833289
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.11324195
10ZNF263_19887448_ChIP-Seq_K562_Human3.06420019
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.95434183
12MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.90430941
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.45645774
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.24838163
15EZH2_22144423_ChIP-Seq_EOC_Human2.20349594
16GATA4_21415370_ChIP-Seq_HL-1_Mouse2.19398017
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.10690504
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.06841473
19EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.82124729
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.81717547
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.81452346
22ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.78092997
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75122394
24NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.72980542
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.72685423
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.70745275
27NFIB_24661679_ChIP-Seq_LUNG_Mouse1.60467958
28CLOCK_20551151_ChIP-Seq_293T_Human1.60094642
29PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.59066567
30TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45883470
31BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.44880444
32EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.41893653
33* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.40188624
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36854327
35* CTCF_27219007_Chip-Seq_Bcells_Human1.35869107
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33658485
37PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.32252309
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.31049494
39BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.30798229
40PPARA_22158963_ChIP-Seq_LIVER_Mouse1.30046481
41NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.28721137
42KDM2B_26808549_Chip-Seq_DND41_Human1.26649388
43* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24318752
44DROSHA_22980978_ChIP-Seq_HELA_Human1.23998404
45SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20478944
46IGF1R_20145208_ChIP-Seq_DFB_Human1.18747651
47PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15255568
48* TP63_22573176_ChIP-Seq_HFKS_Human1.15222190
49SMC3_22415368_ChIP-Seq_MEFs_Mouse1.14627686
50LXR_22158963_ChIP-Seq_LIVER_Mouse1.13919537
51* LXR_22292898_ChIP-Seq_THP-1_Human1.12402125
52FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.12374939
53ZNF274_21170338_ChIP-Seq_K562_Hela1.11472839
54CRX_20693478_ChIP-Seq_RETINA_Mouse1.11174060
55SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08486035
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07964587
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07904710
58* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07688145
59AR_21572438_ChIP-Seq_LNCaP_Human1.07462786
60CTCF_21964334_ChIP-Seq_BJAB-B_Human1.05917595
61P68_20966046_ChIP-Seq_HELA_Human1.05799661
62OCT4_20526341_ChIP-Seq_ESCs_Human1.04770405
63GATA1_22025678_ChIP-Seq_K562_Human1.04637563
64MYC_27129775_Chip-Seq_CORNEA_Mouse1.04000153
65ATF3_27146783_Chip-Seq_COLON_Human1.03762830
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03523058
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.03142045
68SPI1_20517297_ChIP-Seq_HL60_Human1.01085153
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.00778725
70FOXH1_21741376_ChIP-Seq_ESCs_Human0.99359507
71* RACK7_27058665_Chip-Seq_MCF-7_Human0.99287753
72MTF2_20144788_ChIP-Seq_MESCs_Mouse0.99006420
73GATA1_19941826_ChIP-Seq_K562_Human0.97986230
74RUNX1_27514584_Chip-Seq_MCF-7_Human0.97925986
75ESR1_21235772_ChIP-Seq_MCF-7_Human0.96824832
76CTCF_21964334_Chip-Seq_Bcells_Human0.96528517
77UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95881306
78STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.95601794
79CBX2_27304074_Chip-Seq_ESCs_Mouse0.95460599
80RARB_27405468_Chip-Seq_BRAIN_Mouse0.95446904
81SMC1_22415368_ChIP-Seq_MEFs_Mouse0.95091685
82ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95044158
83NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94588138
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94298065
85OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93819266
86RAD21_21589869_ChIP-Seq_MESCs_Mouse0.93606252
87SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92813901
88GATA2_21666600_ChIP-Seq_HMVEC_Human0.92716618
89KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92073576
90RXR_22158963_ChIP-Seq_LIVER_Mouse0.91863336
91SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91147380
92DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90988486
93PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89904833
94GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.89756535
95BCL6_27268052_Chip-Seq_Bcells_Human0.89261949
96* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89070240
97YY1_22570637_ChIP-Seq_MALME-3M_Human0.88774595
98ISL1_27105846_Chip-Seq_CPCs_Mouse0.88439193
99GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.87612855
100TRIM28_21343339_ChIP-Seq_HEK293_Human0.87587789
101CJUN_26792858_Chip-Seq_BT549_Human0.86385299
102SA1_27219007_Chip-Seq_Bcells_Human0.85868030
103MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.85292338
104SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.85114411
105NR3C1_23031785_ChIP-Seq_PC12_Mouse0.84611426
106EZH2_18974828_ChIP-Seq_MESCs_Mouse0.84081972
107RNF2_18974828_ChIP-Seq_MESCs_Mouse0.84081972
108* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.83737824
109LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.83430804
110TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83381965
111SOX9_24532713_ChIP-Seq_HFSC_Mouse0.83009388
112GATA1_19941827_ChIP-Seq_MEL86_Mouse0.82927918
113TP53_20018659_ChIP-ChIP_R1E_Mouse0.81575250
114SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81196503
115BCOR_27268052_Chip-Seq_Bcells_Human0.81190169
116TDRD3_21172665_ChIP-Seq_MCF-7_Human0.80991670
117SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.80293561
118HIF1A_21447827_ChIP-Seq_MCF-7_Human0.80032614
119FOXA2_19822575_ChIP-Seq_HepG2_Human0.79630865
120EZH2_27304074_Chip-Seq_ESCs_Mouse0.79549589
121GATA2_19941826_ChIP-Seq_K562_Human0.79486267
122CTNNB1_20460455_ChIP-Seq_HCT116_Human0.79476642
123GATA1_19941827_ChIP-Seq_MEL_Mouse0.79400837
124E2F1_20622854_ChIP-Seq_HELA_Human0.79361026
125JARID2_20075857_ChIP-Seq_MESCs_Mouse0.79335710
126NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79067714
127NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79067714
128P63_26484246_Chip-Seq_KERATINOCYTES_Human0.78341698
129AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78301313
130* TP53_23651856_ChIP-Seq_MEFs_Mouse0.77923098
131PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.77640167
132KDM2B_26808549_Chip-Seq_K562_Human0.76094397
133PCGF2_27294783_Chip-Seq_NPCs_Mouse0.76014436
134SOX2_21211035_ChIP-Seq_LN229_Gbm0.75731333
135SMC4_20622854_ChIP-Seq_HELA_Human0.75582178
136* CREB1_26743006_Chip-Seq_LNCaP_Human0.75505039
137PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.73323204
138PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.72809861
139P53_22127205_ChIP-Seq_FIBROBLAST_Human0.72640733
140* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.72438821
141SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.71412406
142SUZ12_27294783_Chip-Seq_ESCs_Mouse0.70965377

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.57267981
2MP0003646_muscle_fatigue6.30570800
3MP0000751_myopathy5.68775380
4MP0004084_abnormal_cardiac_muscle4.88992173
5MP0000749_muscle_degeneration4.84873479
6MP0004036_abnormal_muscle_relaxation4.35793363
7MP0004215_abnormal_myocardial_fiber4.08143370
8MP0004145_abnormal_muscle_electrophysio3.81739741
9MP0005330_cardiomyopathy3.56306544
10MP0004087_abnormal_muscle_fiber3.37612026
11MP0000750_abnormal_muscle_regeneration3.16286921
12MP0002106_abnormal_muscle_physiology3.15019406
13MP0005620_abnormal_muscle_contractility2.91675147
14MP0002972_abnormal_cardiac_muscle2.80484854
15MP0000747_muscle_weakness2.77718150
16MP0004130_abnormal_muscle_cell2.76649659
17* MP0002269_muscular_atrophy2.60626401
18* MP0000759_abnormal_skeletal_muscle2.55838964
19* MP0005369_muscle_phenotype2.50904969
20MP0003137_abnormal_impulse_conducting2.46325384
21MP0008775_abnormal_heart_ventricle2.39560735
22MP0010630_abnormal_cardiac_muscle2.36500738
23MP0005385_cardiovascular_system_phenoty2.30327893
24MP0001544_abnormal_cardiovascular_syste2.30327893
25MP0004484_altered_response_of2.24014922
26MP0006138_congestive_heart_failure2.07288064
27MP0006036_abnormal_mitochondrial_physio1.81237873
28MP0003221_abnormal_cardiomyocyte_apopto1.81106075
29MP0003828_pulmonary_edema1.80639645
30MP0004085_abnormal_heartbeat1.73391252
31MP0002332_abnormal_exercise_endurance1.66397129
32MP0005666_abnormal_adipose_tissue1.57121886
33MP0004510_myositis1.53386642
34MP0003950_abnormal_plasma_membrane1.49339315
35MP0002127_abnormal_cardiovascular_syste1.42344484
36MP0004185_abnormal_adipocyte_glucose1.33900292
37MP0000733_abnormal_muscle_development1.25672453
38MP0005670_abnormal_white_adipose1.24223702
39MP0002234_abnormal_pharynx_morphology1.11192048
40MP0005375_adipose_tissue_phenotype1.10457013
41MP0000343_altered_response_to1.07754801
42MP0000266_abnormal_heart_morphology1.02898604
43* MP0002108_abnormal_muscle_morphology1.00705065
44* MP0004233_abnormal_muscle_weight1.00202184
45MP0001661_extended_life_span1.00018093
46MP0006035_abnormal_mitochondrial_morpho0.99734135
47MP0003567_abnormal_fetal_cardiomyocyte0.98491839
48MP0005266_abnormal_metabolism0.92871174
49MP0003279_aneurysm0.89848674
50MP0005165_increased_susceptibility_to0.86213998
51MP0002971_abnormal_brown_adipose0.83375516
52MP0003806_abnormal_nucleotide_metabolis0.78349974
53MP0010368_abnormal_lymphatic_system0.75621208
54MP0003705_abnormal_hypodermis_morpholog0.75529771
55MP0000013_abnormal_adipose_tissue0.72446438
56MP0000230_abnormal_systemic_arterial0.70428189
57MP0010030_abnormal_orbit_morphology0.68871661
58MP0002128_abnormal_blood_circulation0.68686237
59MP0000003_abnormal_adipose_tissue0.64349074
60MP0000372_irregular_coat_pigmentation0.63216538
61MP0005623_abnormal_meninges_morphology0.63094206
62MP0004043_abnormal_pH_regulation0.58501990
63MP0003566_abnormal_cell_adhesion0.56744430
64MP0004147_increased_porphyrin_level0.55082837
65MP0000767_abnormal_smooth_muscle0.54559688
66MP0008961_abnormal_basal_metabolism0.51808623
67MP0002909_abnormal_adrenal_gland0.51705459
68MP0002078_abnormal_glucose_homeostasis0.51139184
69MP0004134_abnormal_chest_morphology0.50986898
70MP0008438_abnormal_cutaneous_collagen0.50751119
71MP0005275_abnormal_skin_tensile0.49591907
72MP0001879_abnormal_lymphatic_vessel0.48031851
73MP0000762_abnormal_tongue_morphology0.47310997
74MP0003879_abnormal_hair_cell0.44622465
75MP0005451_abnormal_body_composition0.43632296
76MP0002114_abnormal_axial_skeleton0.41030347
77MP0005187_abnormal_penis_morphology0.40271421
78MP0001346_abnormal_lacrimal_gland0.39797016
79MP0002249_abnormal_larynx_morphology0.38772484
80MP0005334_abnormal_fat_pad0.37934647
81MP0002925_abnormal_cardiovascular_devel0.37769449
82* MP0005319_abnormal_enzyme/_coenzyme0.36752607
83MP0002896_abnormal_bone_mineralization0.36660592
84MP0009250_abnormal_appendicular_skeleto0.36322371
85MP0002734_abnormal_mechanical_nocicepti0.35584065
86MP0009384_cardiac_valve_regurgitation0.34656804
87MP0003948_abnormal_gas_homeostasis0.33650493
88MP0005535_abnormal_body_temperature0.31424530
89MP0005167_abnormal_blood-brain_barrier0.30619381
90MP0004272_abnormal_basement_membrane0.30239372
91MP0001614_abnormal_blood_vessel0.29909678
92MP0009115_abnormal_fat_cell0.29231667
93MP0001542_abnormal_bone_strength0.29196488
94MP0005083_abnormal_biliary_tract0.29139065
95MP0001943_abnormal_respiration0.29081132
96MP0004142_abnormal_muscle_tone0.28777141
97MP0005166_decreased_susceptibility_to0.28406291
98MP0003656_abnormal_erythrocyte_physiolo0.28240995
99MP0001784_abnormal_fluid_regulation0.27269407
100MP0008569_lethality_at_weaning0.26933161
101MP0003045_fibrosis0.26779089
102MP0004858_abnormal_nervous_system0.26471210
103MP0001299_abnormal_eye_distance/0.26452116
104MP0002877_abnormal_melanocyte_morpholog0.26030500
105MP0002638_abnormal_pupillary_reflex0.25167810
106MP0004270_analgesia0.24997434
107MP0001958_emphysema0.24656915
108MP0009780_abnormal_chondrocyte_physiolo0.24555046
109MP0005452_abnormal_adipose_tissue0.24526515
110MP0005584_abnormal_enzyme/coenzyme_acti0.23837118
111MP0002118_abnormal_lipid_homeostasis0.23234717
112MP0003984_embryonic_growth_retardation0.22999453
113MP0002822_catalepsy0.22880936
114MP0003959_abnormal_lean_body0.22375250
115MP0003195_calcinosis0.22339210
116MP0002088_abnormal_embryonic_growth/wei0.21731749
117MP0009840_abnormal_foam_cell0.21112859
118MP0003011_delayed_dark_adaptation0.20792222
119MP0005376_homeostasis/metabolism_phenot0.20177262
120MP0000249_abnormal_blood_vessel0.19348331
121MP0005332_abnormal_amino_acid0.18809706
122MP0009672_abnormal_birth_weight0.18697957
123MP0001853_heart_inflammation0.18643721
124MP0005595_abnormal_vascular_smooth0.18022743

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)7.30982937
2Exercise-induced muscle cramps (HP:0003710)7.02359956
3Sudden death (HP:0001699)6.80171120
4Muscle fiber splitting (HP:0003555)6.26094551
5* Calf muscle hypertrophy (HP:0008981)5.85267389
6* Muscle hypertrophy of the lower extremities (HP:0008968)5.84316261
7Ventricular tachycardia (HP:0004756)5.72426047
8Muscle fiber inclusion bodies (HP:0100299)5.61345291
9Hyporeflexia of lower limbs (HP:0002600)5.56218852
10Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.47243042
11Myoglobinuria (HP:0002913)5.34691771
12Subaortic stenosis (HP:0001682)4.97463344
13Abnormality of the left ventricular outflow tract (HP:0011103)4.97463344
14* Abnormality of the calf musculature (HP:0001430)4.94164256
15Type 1 muscle fiber predominance (HP:0003803)4.76519109
16Difficulty running (HP:0009046)4.76465542
17Nemaline bodies (HP:0003798)4.75528729
18Atrial fibrillation (HP:0005110)4.71982738
19Increased connective tissue (HP:0009025)4.64029521
20Lipoatrophy (HP:0100578)4.50014724
21Primary atrial arrhythmia (HP:0001692)4.41241608
22* EMG: myopathic abnormalities (HP:0003458)4.41084466
23Supraventricular tachycardia (HP:0004755)4.26390161
24Rhabdomyolysis (HP:0003201)4.25133520
25Supraventricular arrhythmia (HP:0005115)4.17558387
26Myotonia (HP:0002486)4.05528427
27Right ventricular cardiomyopathy (HP:0011663)3.99218585
28Asymmetric septal hypertrophy (HP:0001670)3.97571622
29Bundle branch block (HP:0011710)3.86672001
30Dilated cardiomyopathy (HP:0001644)3.84079621
31Popliteal pterygium (HP:0009756)3.76650004
32Fetal akinesia sequence (HP:0001989)3.74185995
33Difficulty climbing stairs (HP:0003551)3.62360864
34Palpitations (HP:0001962)3.61903992
35Syncope (HP:0001279)3.54596192
36Distal arthrogryposis (HP:0005684)3.53762257
37Muscle stiffness (HP:0003552)3.47394821
38Prolonged QT interval (HP:0001657)3.41722006
39Myopathic facies (HP:0002058)3.33969967
40Abnormality of skeletal muscle fiber size (HP:0012084)3.30311636
41Increased variability in muscle fiber diameter (HP:0003557)3.24538714
42Round ear (HP:0100830)3.23490932
43Heart block (HP:0012722)3.23391338
44Abnormal finger flexion creases (HP:0006143)3.22791770
45Ventricular arrhythmia (HP:0004308)3.21539944
46Neck muscle weakness (HP:0000467)3.08965091
47Abnormal atrioventricular conduction (HP:0005150)3.07601785
48Atrioventricular block (HP:0001678)3.02140784
49Type 2 muscle fiber atrophy (HP:0003554)3.01837829
50Areflexia of lower limbs (HP:0002522)3.00154686
51Distal lower limb muscle weakness (HP:0009053)2.95230914
52Abnormality of placental membranes (HP:0011409)2.81810640
53Amniotic constriction ring (HP:0009775)2.81810640
54Muscle fiber atrophy (HP:0100295)2.77091969
55Ventricular fibrillation (HP:0001663)2.74795985
56Ulnar deviation of the wrist (HP:0003049)2.72910941
57Rimmed vacuoles (HP:0003805)2.67952112
58Abnormality of the calcaneus (HP:0008364)2.60506087
59Left ventricular hypertrophy (HP:0001712)2.49373361
60Abnormal mitochondria in muscle tissue (HP:0008316)2.46512673
61Mildly elevated creatine phosphokinase (HP:0008180)2.45781443
62Abnormal EKG (HP:0003115)2.45418723
63Gowers sign (HP:0003391)2.45011318
64Hip contracture (HP:0003273)2.44953670
65Acute necrotizing encephalopathy (HP:0006965)2.42597887
66Distal lower limb amyotrophy (HP:0008944)2.40689995
67Hepatic necrosis (HP:0002605)2.40404034
68EMG: neuropathic changes (HP:0003445)2.38860064
69Testicular atrophy (HP:0000029)2.36820292
70Generalized muscle weakness (HP:0003324)2.34978726
71Muscular dystrophy (HP:0003560)2.34359294
72Ketoacidosis (HP:0001993)2.30103388
73Slender build (HP:0001533)2.28518366
74Facial diplegia (HP:0001349)2.27324058
75Hypoplastic ischia (HP:0003175)2.26086869
76Frequent falls (HP:0002359)2.21352579
77Aplasia of the musculature (HP:0100854)2.19544598
78Calcaneovalgus deformity (HP:0001848)2.18813827
79Palmoplantar keratoderma (HP:0000982)2.17023718
80Respiratory insufficiency due to muscle weakness (HP:0002747)2.16685719
81Abnormality of the neuromuscular junction (HP:0003398)2.14236446
82Fatigable weakness (HP:0003473)2.14236446
83Scapular winging (HP:0003691)2.12675367
84Hepatocellular necrosis (HP:0001404)2.12374391
85Increased muscle lipid content (HP:0009058)2.12158096
86Malignant hyperthermia (HP:0002047)2.12032168
87Absent phalangeal crease (HP:0006109)2.09154040
88Acute encephalopathy (HP:0006846)2.08843753
89Easy fatigability (HP:0003388)2.07002673
90Proximal amyotrophy (HP:0007126)2.06801844
91Waddling gait (HP:0002515)2.05011275
92Exercise intolerance (HP:0003546)2.03793122
93Hyperkalemia (HP:0002153)2.02263184
94Abnormality of the foot musculature (HP:0001436)2.01289564
95Progressive macrocephaly (HP:0004481)1.98915342
96Weak cry (HP:0001612)1.98377912
97Bulbar palsy (HP:0001283)1.98341517
98Deformed tarsal bones (HP:0008119)1.97580423
99Foot dorsiflexor weakness (HP:0009027)1.97562150
100Centrally nucleated skeletal muscle fibers (HP:0003687)1.97244867
101Abnormality of the shoulder girdle musculature (HP:0001435)1.96940345
102Mitochondrial inheritance (HP:0001427)1.96821588
103Progressive muscle weakness (HP:0003323)1.96496524
104Abnormality of the ischium (HP:0003174)1.96449855
105Nonprogressive disorder (HP:0003680)1.96389689
106Hypoglycemic coma (HP:0001325)1.92842834
107Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.89974723
108Metatarsus adductus (HP:0001840)1.89375382
109Spinal rigidity (HP:0003306)1.89327064
110Cerebral edema (HP:0002181)1.88106573
111Conjunctival hamartoma (HP:0100780)1.87804859
112Abnormality of fatty-acid metabolism (HP:0004359)1.85858840
113Long clavicles (HP:0000890)1.85376354
114Dicarboxylic aciduria (HP:0003215)1.84473821
115Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84473821
116Lower limb amyotrophy (HP:0007210)1.84407778
117Increased CSF lactate (HP:0002490)1.84300551
118Increased intramyocellular lipid droplets (HP:0012240)1.82607808
119Ragged-red muscle fibers (HP:0003200)1.78908334
120Thin ribs (HP:0000883)1.76426228
121Limited hip movement (HP:0008800)1.68962149
122Pterygium (HP:0001059)1.66324240
123Abnormality of the musculature of the pelvis (HP:0001469)1.59475360
124Abnormality of the hip-girdle musculature (HP:0001445)1.59475360
125Ulnar deviation of finger (HP:0009465)1.51018632
126Hypoplastic heart (HP:0001961)1.47212618
127Steppage gait (HP:0003376)1.46320592
128Akinesia (HP:0002304)1.45994965
129Generalized amyotrophy (HP:0003700)1.45796296

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN6.77818814
2OBSCN5.74336234
3PHKG24.71186466
4PHKG14.71186466
5PDK43.26130215
6PDK33.26130215
7DMPK2.90558544
8MYLK2.87962584
9LMTK22.84962887
10TRIB32.68170501
11MUSK2.65982145
12BCKDK2.44513024
13PKN22.30520798
14PINK12.25637721
15NEK12.25601088
16PIK3CA2.17042812
17PDK22.01176556
18MOS1.67733223
19NME11.61351394
20MAP2K31.58555502
21PIK3CG1.48536619
22TIE11.47227358
23STK241.40693133
24MAP3K71.36711750
25LIMK11.31218800
26MAPK121.27094715
27MARK11.16557109
28PAK31.08238243
29PRKD11.05105064
30CCNB11.02209649
31ILK1.01093031
32GRK70.99421743
33CAMK2D0.97811399
34MAPKAPK30.97547004
35PRKAA10.90227372
36ZAK0.88927540
37ROCK10.86454241
38PRKAA20.84656446
39TRPM70.79854620
40RIPK10.78788093
41MAP3K30.76821845
42MAP3K50.76339443
43DYRK1B0.75087047
44PKN10.71952766
45MAP3K130.68184699
46CDC42BPA0.67919954
47STK38L0.66702799
48EPHB10.65795115
49STK40.61426340
50INSRR0.58654041
51PDGFRA0.58208874
52ERBB30.56833949
53WNK40.56454878
54ICK0.55958723
55MAP2K60.54663028
56MAP2K40.53826971
57DAPK30.53545849
58FLT30.53487043
59NEK90.53475944
60MAPK40.52498263
61ROCK20.51582252
62STK380.49357519
63CAMK40.47533508
64PRKACB0.47098538
65AKT20.45981447
66KSR20.45872118
67TGFBR20.45613814
68CAMK2G0.43634224
69CAMK2B0.43340557
70CAMK2A0.43042178
71PTK2B0.41685920
72RPS6KL10.40544269
73RPS6KC10.40544269
74SIK10.38223414
75WNK10.37246326
76PRKACA0.34280140
77RPS6KA60.33703245
78PDPK10.32886466
79PTK60.32471876
80PRKD30.31902465
81ARAF0.30530442
82KDR0.30489027
83CAMK10.28850325
84PRKACG0.28845825
85MAPK110.26998716
86TAOK10.26366229
87PDK10.25039852
88SGK20.25021740
89MAPK100.24541730
90PRKCE0.23482390
91MAPK130.22098648
92RPS6KA10.21679258
93PRKG10.21477329
94CDK190.21110055
95MTOR0.20859878
96SGK10.20718247
97PRKCH0.20221756
98RPS6KB10.20097777
99MARK20.20020266
100TBK10.19426786
101MAP3K60.19186825
102MAP3K110.19045452
103RPS6KA30.18980273
104RPS6KB20.17327135
105SGK30.16624834
106LATS20.16580729
107NME20.15673408
108EPHA30.15564495
109MAP3K10.15513417
110MAPK70.14979531
111EEF2K0.14781650
112MAP3K100.13763912
113EPHB20.13376989
114FER0.12547067
115TAOK20.12296466
116PAK60.11951950
117MAP2K10.11887489
118RPS6KA20.11839889
119LRRK20.11819656
120DDR20.11418397
121LATS10.10913035
122RET0.10733223
123STK390.10639939
124JAK10.10303115
125DAPK20.10289477
126SGK4940.08237554
127SGK2230.08237554
128PRPF4B0.07356426
129RAF10.06394253
130BRAF0.05173968
131PRKG20.04806863

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.71248334
2Cardiac muscle contraction_Homo sapiens_hsa042604.39330599
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.22612497
4* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.80792600
5* Dilated cardiomyopathy_Homo sapiens_hsa054143.74428807
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.30479098
7Propanoate metabolism_Homo sapiens_hsa006403.18671568
8Parkinsons disease_Homo sapiens_hsa050123.02800331
9Oxidative phosphorylation_Homo sapiens_hsa001902.90649726
10Fatty acid degradation_Homo sapiens_hsa000712.64576749
11* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.59367978
12Carbon metabolism_Homo sapiens_hsa012002.47801513
13Alzheimers disease_Homo sapiens_hsa050102.30808187
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.13676054
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.13529869
16Fatty acid metabolism_Homo sapiens_hsa012121.99572768
17Huntingtons disease_Homo sapiens_hsa050161.82990176
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.80221447
19Pyruvate metabolism_Homo sapiens_hsa006201.79804390
20Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.44763962
21Starch and sucrose metabolism_Homo sapiens_hsa005001.40622418
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38857280
23Glucagon signaling pathway_Homo sapiens_hsa049221.32097364
24* Viral myocarditis_Homo sapiens_hsa054161.31999875
25Insulin resistance_Homo sapiens_hsa049311.28121440
26Biosynthesis of amino acids_Homo sapiens_hsa012301.20721696
27Adipocytokine signaling pathway_Homo sapiens_hsa049201.19337565
28Butanoate metabolism_Homo sapiens_hsa006501.19112845
29Insulin signaling pathway_Homo sapiens_hsa049101.18893728
30cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06704434
31PPAR signaling pathway_Homo sapiens_hsa033201.02597508
32Fatty acid elongation_Homo sapiens_hsa000621.01413030
33Oxytocin signaling pathway_Homo sapiens_hsa049210.96099149
34Calcium signaling pathway_Homo sapiens_hsa040200.94232042
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91727863
36AMPK signaling pathway_Homo sapiens_hsa041520.91392212
37Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90777348
38Focal adhesion_Homo sapiens_hsa045100.83263989
39Galactose metabolism_Homo sapiens_hsa000520.80911054
40Arginine and proline metabolism_Homo sapiens_hsa003300.80248865
41Vascular smooth muscle contraction_Homo sapiens_hsa042700.74561361
42Arginine biosynthesis_Homo sapiens_hsa002200.73847040
43HIF-1 signaling pathway_Homo sapiens_hsa040660.71895759
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71265813
45Tight junction_Homo sapiens_hsa045300.70853368
46Fructose and mannose metabolism_Homo sapiens_hsa000510.69727342
47beta-Alanine metabolism_Homo sapiens_hsa004100.68667087
48Long-term potentiation_Homo sapiens_hsa047200.67348557
49Tryptophan metabolism_Homo sapiens_hsa003800.67184583
50Nitrogen metabolism_Homo sapiens_hsa009100.66364556
51Circadian rhythm_Homo sapiens_hsa047100.66324267
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64106569
53Lysine degradation_Homo sapiens_hsa003100.63134079
54Fatty acid biosynthesis_Homo sapiens_hsa000610.62277437
55Type II diabetes mellitus_Homo sapiens_hsa049300.61610472
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59038182
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.58020043
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55678447
59Renin secretion_Homo sapiens_hsa049240.51639119
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49818666
61Salivary secretion_Homo sapiens_hsa049700.48773795
62Phenylalanine metabolism_Homo sapiens_hsa003600.48636070
63Gastric acid secretion_Homo sapiens_hsa049710.48608025
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46884660
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44821935
66ECM-receptor interaction_Homo sapiens_hsa045120.42892527
67Peroxisome_Homo sapiens_hsa041460.41712997
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40905436
69Insulin secretion_Homo sapiens_hsa049110.38172858
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37674965
71cAMP signaling pathway_Homo sapiens_hsa040240.35783632
72Adherens junction_Homo sapiens_hsa045200.35641467
73Amoebiasis_Homo sapiens_hsa051460.34958330
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32031145
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29033582
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28056777
77Amphetamine addiction_Homo sapiens_hsa050310.27133711
78GnRH signaling pathway_Homo sapiens_hsa049120.26818815
79Melanogenesis_Homo sapiens_hsa049160.25925438
80VEGF signaling pathway_Homo sapiens_hsa043700.25084733
81Histidine metabolism_Homo sapiens_hsa003400.24458264
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.23774175
83Platelet activation_Homo sapiens_hsa046110.23390919
84Long-term depression_Homo sapiens_hsa047300.23322979
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.23066449
86mTOR signaling pathway_Homo sapiens_hsa041500.22834285
87Renal cell carcinoma_Homo sapiens_hsa052110.22434727
88Proteoglycans in cancer_Homo sapiens_hsa052050.22180104
89Metabolic pathways_Homo sapiens_hsa011000.21797541
90FoxO signaling pathway_Homo sapiens_hsa040680.20552071
91Pentose phosphate pathway_Homo sapiens_hsa000300.19287907
92Glioma_Homo sapiens_hsa052140.19197792
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19044043
94Regulation of autophagy_Homo sapiens_hsa041400.18308749
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.18050157
96Circadian entrainment_Homo sapiens_hsa047130.16395335
97MAPK signaling pathway_Homo sapiens_hsa040100.16365500
98Fat digestion and absorption_Homo sapiens_hsa049750.14536606
99Dorso-ventral axis formation_Homo sapiens_hsa043200.13535241
100Olfactory transduction_Homo sapiens_hsa047400.13455408
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.13289779
102Tyrosine metabolism_Homo sapiens_hsa003500.10880623
103Gap junction_Homo sapiens_hsa045400.10826784
104Sulfur relay system_Homo sapiens_hsa041220.10709211
105Pancreatic secretion_Homo sapiens_hsa049720.08797053
106Cholinergic synapse_Homo sapiens_hsa047250.07897750
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.07409281
108Ovarian steroidogenesis_Homo sapiens_hsa049130.07218004
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.06373835
110Glycerolipid metabolism_Homo sapiens_hsa005610.03963139
111Bile secretion_Homo sapiens_hsa049760.03429714
112Toxoplasmosis_Homo sapiens_hsa051450.03053751
113Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.01628876
114Notch signaling pathway_Homo sapiens_hsa043300.01590941
115Acute myeloid leukemia_Homo sapiens_hsa05221-0.0426722
116alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0417757

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