SGCD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. Mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sphingosine metabolic process (GO:0006670)7.81135228
2diol metabolic process (GO:0034311)6.93221338
3sphingoid metabolic process (GO:0046519)6.20781198
4regulation of sequestering of triglyceride (GO:0010889)5.21063877
5paraxial mesoderm development (GO:0048339)5.10627174
6response to muscle activity (GO:0014850)5.06796776
7plasma membrane repair (GO:0001778)5.03744198
8carnitine shuttle (GO:0006853)4.90757012
9sarcomere organization (GO:0045214)4.89644428
10cardiac myofibril assembly (GO:0055003)4.83335053
11fatty acid transmembrane transport (GO:1902001)4.69049387
12positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.68882293
13regulation of odontogenesis of dentin-containing tooth (GO:0042487)4.68128401
14positive regulation of fatty acid oxidation (GO:0046321)4.62017974
15skeletal muscle contraction (GO:0003009)4.60612709
16regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.58178959
17positive regulation of fatty acid beta-oxidation (GO:0032000)4.55540362
18response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.52553305
19muscle filament sliding (GO:0030049)4.49835223
20actin-myosin filament sliding (GO:0033275)4.49835223
21regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.47624706
22regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.38773103
23myofibril assembly (GO:0030239)4.35824578
24response to inactivity (GO:0014854)4.34136113
25regulation of skeletal muscle contraction (GO:0014819)4.24415127
26protein-chromophore linkage (GO:0018298)4.23921561
27low-density lipoprotein particle clearance (GO:0034383)4.13869035
28collagen fibril organization (GO:0030199)4.13649117
29actin-mediated cell contraction (GO:0070252)4.09058598
30regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.04997930
31lipopolysaccharide biosynthetic process (GO:0009103)4.04625993
32heart contraction (GO:0060047)4.00091591
33heart process (GO:0003015)4.00091591
34brown fat cell differentiation (GO:0050873)3.97333659
35regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.93756274
36protein heterotrimerization (GO:0070208)3.92376929
37negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.86638085
38regulation of relaxation of muscle (GO:1901077)3.83076792
39regulation of protein glycosylation (GO:0060049)3.81975352
40regulation of fatty acid oxidation (GO:0046320)3.78971638
41negative regulation of protein localization to cell surface (GO:2000009)3.77747557
42notochord development (GO:0030903)3.77701500
43regulation of pigment cell differentiation (GO:0050932)3.77642200
44SMAD protein complex assembly (GO:0007183)3.76749149
45regulation of cell communication by electrical coupling (GO:0010649)3.71575695
46negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.70272049
47tricarboxylic acid cycle (GO:0006099)3.67926382
48lipid particle organization (GO:0034389)3.65982090
49regulation of acyl-CoA biosynthetic process (GO:0050812)3.60874171
50regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.58172548
51carnitine transmembrane transport (GO:1902603)3.57143529
52white fat cell differentiation (GO:0050872)3.49103647
53actomyosin structure organization (GO:0031032)3.45500622
54cardiac muscle cell development (GO:0055013)3.44376781
55insulin-like growth factor receptor signaling pathway (GO:0048009)3.44271008
56retina vasculature morphogenesis in camera-type eye (GO:0061299)3.43815391
57regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.40224690
58regulation of sarcomere organization (GO:0060297)3.36989908
59positive regulation of glycogen biosynthetic process (GO:0045725)3.36046791
60cardiac cell development (GO:0055006)3.35842557
61regulation of transforming growth factor beta2 production (GO:0032909)3.35171307
62regulation of meiosis I (GO:0060631)3.33218434
63striated muscle atrophy (GO:0014891)3.33157263
64actin filament-based movement (GO:0030048)3.32924063
65lipopolysaccharide metabolic process (GO:0008653)3.32229449
66sarcoplasmic reticulum calcium ion transport (GO:0070296)3.32218178
67DNA methylation involved in gamete generation (GO:0043046)3.32141668
68negative regulation of potassium ion transmembrane transport (GO:1901380)3.31901349
69positive regulation of myotube differentiation (GO:0010831)3.30027093
70muscle system process (GO:0003012)3.28187945
71fatty acid beta-oxidation (GO:0006635)3.25993301
72regulation of cofactor metabolic process (GO:0051193)3.25926904
73regulation of coenzyme metabolic process (GO:0051196)3.25926904
74biotin metabolic process (GO:0006768)3.24293163
75positive regulation of developmental pigmentation (GO:0048087)3.22333664
76regulation of fatty acid beta-oxidation (GO:0031998)3.22062158
77valine metabolic process (GO:0006573)3.21147029
78carnitine transport (GO:0015879)3.18549826
79amino-acid betaine transport (GO:0015838)3.18549826
80skeletal muscle fiber development (GO:0048741)3.18098203
81regulation of the force of heart contraction (GO:0002026)3.18034074
82skeletal muscle adaptation (GO:0043501)3.17887836
83skeletal muscle tissue development (GO:0007519)3.17264913
84cardiac muscle contraction (GO:0060048)3.16923973
85muscle cell cellular homeostasis (GO:0046716)3.14647098
86triglyceride catabolic process (GO:0019433)3.11102814
87myotube cell development (GO:0014904)3.08525180
88negative regulation of glycoprotein biosynthetic process (GO:0010561)3.08140152
89muscle atrophy (GO:0014889)3.07500104
90negative regulation of cell cycle G2/M phase transition (GO:1902750)3.07054810
91cardiac muscle tissue morphogenesis (GO:0055008)3.04207906
92sulfate transmembrane transport (GO:1902358)3.00989176
93cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.99054485
94negative regulation of stem cell proliferation (GO:2000647)2.96972082
95response to mercury ion (GO:0046689)2.95658660
96growth hormone receptor signaling pathway (GO:0060396)2.93516669
97* muscle organ development (GO:0007517)2.93243055
98myoblast fusion (GO:0007520)2.92769849
99sequestering of extracellular ligand from receptor (GO:0035581)2.91925550
100* muscle structure development (GO:0061061)2.91512987
101positive regulation of cellular response to insulin stimulus (GO:1900078)2.88822854
102intracellular lipid transport (GO:0032365)2.88562043
103cellular response to epinephrine stimulus (GO:0071872)2.85964531
104cell migration involved in heart development (GO:0060973)2.85914705
105positive regulation of glycogen metabolic process (GO:0070875)2.85112770
106positive regulation of myoblast differentiation (GO:0045663)2.84479804
107glomerular basement membrane development (GO:0032836)2.82522376
108negative regulation of BMP signaling pathway (GO:0030514)2.82176426
109muscle cell fate commitment (GO:0042693)2.80013710
110negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.79648012
111muscle tissue morphogenesis (GO:0060415)2.78726660
112fibroblast migration (GO:0010761)2.77858180
113regulation of striated muscle contraction (GO:0006942)2.77407335
114tyrosine metabolic process (GO:0006570)2.76966036
115neutral lipid catabolic process (GO:0046461)2.76657899
116acylglycerol catabolic process (GO:0046464)2.76657899
117striated muscle adaptation (GO:0014888)2.76464355
118muscle hypertrophy (GO:0014896)2.75700564
119ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.75514255
120positive regulation of glucose import (GO:0046326)2.75368676
121muscle fiber development (GO:0048747)2.75061667
122epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.73190212
123detection of calcium ion (GO:0005513)2.72611503
124heart trabecula formation (GO:0060347)2.71116306
125striated muscle contraction (GO:0006941)2.70891057
126regulation of actin filament-based movement (GO:1903115)2.70796675
127protein hydroxylation (GO:0018126)2.70493776
128peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.69604700
129collagen catabolic process (GO:0030574)2.69201542
130ribonucleoprotein complex disassembly (GO:0032988)2.68461987
131regulation of sulfur metabolic process (GO:0042762)2.68347453
132collagen metabolic process (GO:0032963)2.67557849
133response to epinephrine (GO:0071871)2.67211931
134negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.65808653
135positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.65341151
136neuron projection extension involved in neuron projection guidance (GO:1902284)2.65324164
137axon extension involved in axon guidance (GO:0048846)2.65324164
138positive regulation of fatty acid metabolic process (GO:0045923)2.62947826
139regulation of tight junction assembly (GO:2000810)2.62424199
140fatty acid oxidation (GO:0019395)2.60885206
141cardiac muscle hypertrophy (GO:0003300)2.59724503
142cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.59601197
143regulation of glucose import in response to insulin stimulus (GO:2001273)2.59316033
144cardiac muscle cell proliferation (GO:0060038)2.58377688
145positive regulation of insulin receptor signaling pathway (GO:0046628)2.58195918
146adult heart development (GO:0007512)2.58033913
147creatine metabolic process (GO:0006600)2.57443195
148fatty acid catabolic process (GO:0009062)2.56811194
149ventricular cardiac muscle cell action potential (GO:0086005)2.56753169
150muscle contraction (GO:0006936)2.56743432
151protein targeting to plasma membrane (GO:0072661)2.54515506
152chondrocyte proliferation (GO:0035988)2.54082263
153lipid oxidation (GO:0034440)2.53893444
154regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.53283482
155glomerular filtration (GO:0003094)2.52507170
156fatty acid homeostasis (GO:0055089)2.50848913
157striated muscle hypertrophy (GO:0014897)2.50809406
158regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.50731564
159heart morphogenesis (GO:0003007)2.49564823
160nucleus localization (GO:0051647)2.48714755

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.00954778
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.06463339
3TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.43282880
4EP300_21415370_ChIP-Seq_HL-1_Mouse3.19365930
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.19159887
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.57539695
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.53970128
8ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.50037220
9CLOCK_20551151_ChIP-Seq_293T_Human2.44418681
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.34084450
11IGF1R_20145208_ChIP-Seq_DFB_Human2.27598296
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.18091359
13CJUN_26792858_Chip-Seq_BT549_Human2.16025534
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.12393105
15GBX2_23144817_ChIP-Seq_PC3_Human2.09945109
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.09613616
17EZH2_22144423_ChIP-Seq_EOC_Human2.01277179
18CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.95598011
19TBX20_22080862_ChIP-Seq_HEART_Mouse1.95078031
20TBX20_22328084_ChIP-Seq_HEART_Mouse1.95078031
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89808041
22ESR1_20079471_ChIP-ChIP_T-47D_Human1.82860251
23WT1_19549856_ChIP-ChIP_CCG9911_Human1.82815906
24NRF2_20460467_ChIP-Seq_MEFs_Mouse1.78676990
25NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.78676990
26MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.73780886
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72001076
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72001076
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69208062
30* PIAS1_25552417_ChIP-Seq_VCAP_Human1.67796651
31TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.64917574
32* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.64905152
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.62883405
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.61207912
35EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.59243812
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58731204
37* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.58403806
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.58110891
39TP63_17297297_ChIP-ChIP_HaCaT_Human1.55532809
40FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.52526222
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49067684
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48727191
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.47629341
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46656341
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46471240
46AR_21572438_ChIP-Seq_LNCaP_Human1.42668011
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.42308040
48* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.41837426
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.38193542
50NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.37605429
51CTNNB1_20460455_ChIP-Seq_HCT116_Human1.36495536
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.35716922
53TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.35364083
54* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.34983584
55EED_16625203_ChIP-ChIP_MESCs_Mouse1.34788077
56HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33767345
57* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32061198
58BCAT_22108803_ChIP-Seq_LS180_Human1.31620780
59TP53_16413492_ChIP-PET_HCT116_Human1.31126630
60BRD4_25478319_ChIP-Seq_HGPS_Human1.30351629
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.29399573
62SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.28243864
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.27931824
64* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27423632
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.27101927
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26786729
67TP53_18474530_ChIP-ChIP_U2OS_Human1.25627297
68P300_19829295_ChIP-Seq_ESCs_Human1.25337689
69PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.25204165
70SMAD3_21741376_ChIP-Seq_HESCs_Human1.25150492
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24886378
72SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.24732672
73TCF4_18268006_ChIP-ChIP_LS174T_Human1.23726555
74* SMAD4_21799915_ChIP-Seq_A2780_Human1.23176620
75* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22620481
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22592177
77PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.22577129
78* EZH2_27304074_Chip-Seq_ESCs_Mouse1.22491123
79ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21032771
80STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.20443161
81ESR1_21235772_ChIP-Seq_MCF-7_Human1.19999989
82SOX2_21211035_ChIP-Seq_LN229_Gbm1.19789923
83MTF2_20144788_ChIP-Seq_MESCs_Mouse1.18771796
84ISL1_27105846_Chip-Seq_CPCs_Mouse1.18673257
85SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.18660069
86RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18596526
87ESR2_21235772_ChIP-Seq_MCF-7_Human1.17378816
88SALL4_18804426_ChIP-ChIP_XEN_Mouse1.15465725
89* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15036165
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.14481544
91OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13776614
92GATA4_21415370_ChIP-Seq_HL-1_Mouse1.12937677
93GATA2_21666600_ChIP-Seq_HMVEC_Human1.12923130
94AHR_22903824_ChIP-Seq_MCF-7_Human1.12538211
95NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11304022
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10104471
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09754158
98RXR_22108803_ChIP-Seq_LS180_Human1.09679434
99WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09569632
100POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09004207
101* TCF4_23295773_ChIP-Seq_U87_Human1.06590980
102* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05131850
103TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04771446
104WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04627598
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04338441
106* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04148106
107TP53_20018659_ChIP-ChIP_R1E_Mouse1.03889283
108SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03696365
109NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03616574
110STAT3_23295773_ChIP-Seq_U87_Human1.02730742
111SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.02702028
112TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02282263
113SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02025125
114TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01698985
115JARID2_20064375_ChIP-Seq_MESCs_Mouse1.01614954
116DROSHA_22980978_ChIP-Seq_HELA_Human1.00776970
117NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99785401
118PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99368423
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99276396
120JARID2_20075857_ChIP-Seq_MESCs_Mouse0.98693678
121PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98267373
122SMAD4_21741376_ChIP-Seq_HESCs_Human0.98060310
123TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97383029
124SMAD3_21741376_ChIP-Seq_EPCs_Human0.97010656
125ARNT_22903824_ChIP-Seq_MCF-7_Human0.96896694
126ER_23166858_ChIP-Seq_MCF-7_Human0.96368650
127ZNF274_21170338_ChIP-Seq_K562_Hela0.95688583
128SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95588822
129* RNF2_27304074_Chip-Seq_ESCs_Mouse0.94506516
130* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93672790
131HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92611041
132AR_25329375_ChIP-Seq_VCAP_Human0.89875262
133* AR_19668381_ChIP-Seq_PC3_Human0.89623378
134* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89237192

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.41651470
2MP0003136_yellow_coat_color4.62914822
3* MP0002837_dystrophic_cardiac_calcinosis4.43879848
4MP0005670_abnormal_white_adipose4.37052858
5MP0005275_abnormal_skin_tensile3.68120362
6MP0000751_myopathy3.67158587
7MP0003646_muscle_fatigue3.57352595
8MP0005666_abnormal_adipose_tissue3.19318606
9MP0004130_abnormal_muscle_cell3.11605633
10MP0004084_abnormal_cardiac_muscle2.96671146
11MP0004215_abnormal_myocardial_fiber2.89623734
12MP0005503_abnormal_tendon_morphology2.84259214
13MP0000013_abnormal_adipose_tissue2.68156731
14MP0004185_abnormal_adipocyte_glucose2.60484195
15MP0004272_abnormal_basement_membrane2.58045461
16MP0003705_abnormal_hypodermis_morpholog2.53192458
17* MP0000749_muscle_degeneration2.46461630
18MP0005375_adipose_tissue_phenotype2.43207101
19MP0004036_abnormal_muscle_relaxation2.27473091
20MP0004087_abnormal_muscle_fiber2.26711557
21MP0000569_abnormal_digit_pigmentation2.24993501
22MP0008775_abnormal_heart_ventricle2.19350093
23MP0000750_abnormal_muscle_regeneration2.16335361
24MP0002653_abnormal_ependyma_morphology2.08930232
25MP0004145_abnormal_muscle_electrophysio2.07871152
26* MP0005330_cardiomyopathy2.06073876
27* MP0005620_abnormal_muscle_contractility2.02855411
28MP0000003_abnormal_adipose_tissue1.99150510
29MP0002972_abnormal_cardiac_muscle1.98203716
30MP0003279_aneurysm1.95045093
31MP0003879_abnormal_hair_cell1.92454557
32MP0002108_abnormal_muscle_morphology1.86620164
33MP0004484_altered_response_of1.78846308
34* MP0000759_abnormal_skeletal_muscle1.77978858
35MP0003890_abnormal_embryonic-extraembry1.77365094
36MP0006138_congestive_heart_failure1.75094972
37MP0003950_abnormal_plasma_membrane1.68267641
38MP0009384_cardiac_valve_regurgitation1.63431810
39* MP0002106_abnormal_muscle_physiology1.60002708
40* MP0001544_abnormal_cardiovascular_syste1.59203645
41* MP0005385_cardiovascular_system_phenoty1.59203645
42* MP0005369_muscle_phenotype1.55712961
43MP0009780_abnormal_chondrocyte_physiolo1.54582477
44MP0010630_abnormal_cardiac_muscle1.52962904
45MP0001958_emphysema1.49276084
46MP0002971_abnormal_brown_adipose1.47310051
47MP0000747_muscle_weakness1.45214871
48MP0004381_abnormal_hair_follicle1.44293943
49* MP0002269_muscular_atrophy1.44270989
50* MP0003137_abnormal_impulse_conducting1.43471312
51MP0003828_pulmonary_edema1.37848134
52MP0009115_abnormal_fat_cell1.31072868
53MP0009250_abnormal_appendicular_skeleto1.30997470
54MP0006054_spinal_hemorrhage1.25845979
55MP0001299_abnormal_eye_distance/1.24908388
56MP0004510_myositis1.24633570
57MP0004233_abnormal_muscle_weight1.21792086
58MP0000372_irregular_coat_pigmentation1.17217142
59MP0005334_abnormal_fat_pad1.17163266
60MP0003566_abnormal_cell_adhesion1.15964078
61MP0001542_abnormal_bone_strength1.11677172
62MP0004085_abnormal_heartbeat1.10791069
63MP0000733_abnormal_muscle_development1.09833715
64MP0002060_abnormal_skin_morphology1.08957299
65MP0002938_white_spotting1.08171077
66MP0005257_abnormal_intraocular_pressure1.07846328
67MP0000534_abnormal_ureter_morphology1.07685727
68MP0002295_abnormal_pulmonary_circulatio1.07632330
69MP0005623_abnormal_meninges_morphology1.03355032
70MP0010352_gastrointestinal_tract_polyps1.00927521
71MP0003959_abnormal_lean_body1.00761965
72MP0004134_abnormal_chest_morphology1.00588638
73MP0010368_abnormal_lymphatic_system0.97828302
74MP0005508_abnormal_skeleton_morphology0.97491754
75MP0003385_abnormal_body_wall0.95906142
76MP0001661_extended_life_span0.92968853
77MP0002970_abnormal_white_adipose0.92257265
78* MP0003045_fibrosis0.91263986
79MP0003221_abnormal_cardiomyocyte_apopto0.88413099
80MP0004270_analgesia0.87076243
81MP0005165_increased_susceptibility_to0.83831343
82MP0002075_abnormal_coat/hair_pigmentati0.82808304
83MP0002896_abnormal_bone_mineralization0.82410253
84MP0001879_abnormal_lymphatic_vessel0.81313099
85MP0002332_abnormal_exercise_endurance0.81147679
86MP0000343_altered_response_to0.80584103
87MP0000163_abnormal_cartilage_morphology0.80222841
88* MP0000266_abnormal_heart_morphology0.80125462
89MP0005451_abnormal_body_composition0.78096210
90MP0002127_abnormal_cardiovascular_syste0.77759574
91MP0005595_abnormal_vascular_smooth0.76380274
92MP0002876_abnormal_thyroid_physiology0.73961128
93MP0002128_abnormal_blood_circulation0.72732229
94MP0002095_abnormal_skin_pigmentation0.70966281
95MP0000230_abnormal_systemic_arterial0.69775312
96MP0002115_abnormal_skeleton_extremities0.69677437
97MP0005075_abnormal_melanosome_morpholog0.68249612
98MP0003091_abnormal_cell_migration0.67292593
99MP0004147_increased_porphyrin_level0.66179220
100* MP0002168_other_aberrant_phenotype0.65237582
101MP0005535_abnormal_body_temperature0.65117550
102MP0002078_abnormal_glucose_homeostasis0.64376789
103MP0000767_abnormal_smooth_muscle0.64307367
104MP0003941_abnormal_skin_development0.62260055
105MP0005452_abnormal_adipose_tissue0.61225222
106MP0010030_abnormal_orbit_morphology0.60846794
107MP0005388_respiratory_system_phenotype0.60068431
108MP0002133_abnormal_respiratory_system0.60068431
109MP0005171_absent_coat_pigmentation0.60030494
110MP0003935_abnormal_craniofacial_develop0.59935911
111MP0005085_abnormal_gallbladder_physiolo0.59238541
112MP0002909_abnormal_adrenal_gland0.58821865
113MP0003948_abnormal_gas_homeostasis0.57929798
114MP0008569_lethality_at_weaning0.57674060
115MP0001186_pigmentation_phenotype0.56907650
116MP0001177_atelectasis0.56271033
117MP0002877_abnormal_melanocyte_morpholog0.56221243
118MP0003937_abnormal_limbs/digits/tail_de0.54756405
119MP0005266_abnormal_metabolism0.53674981
120MP0000428_abnormal_craniofacial_morphol0.52798333
121MP0002249_abnormal_larynx_morphology0.52471724
122MP0003942_abnormal_urinary_system0.51395898
123MP0005448_abnormal_energy_balance0.51018092
124MP0003755_abnormal_palate_morphology0.50871989
125* MP0001614_abnormal_blood_vessel0.50566543
126MP0000015_abnormal_ear_pigmentation0.49386137
127MP0005174_abnormal_tail_pigmentation0.44718789
128MP0002138_abnormal_hepatobiliary_system0.40908730
129MP0008770_decreased_survivor_rate0.39617163
130MP0002160_abnormal_reproductive_system0.38859726

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber splitting (HP:0003555)4.88719550
2Increased connective tissue (HP:0009025)4.82667642
3Sudden death (HP:0001699)4.69799515
4Type 1 muscle fiber predominance (HP:0003803)4.35842154
5Protrusio acetabuli (HP:0003179)4.30617684
6Calf muscle hypertrophy (HP:0008981)4.28164888
7Premature rupture of membranes (HP:0001788)4.13775635
8* Lipoatrophy (HP:0100578)4.13229449
9Ulnar deviation of the wrist (HP:0003049)4.09576535
10Hyporeflexia of lower limbs (HP:0002600)4.04163240
11Abnormality of the calf musculature (HP:0001430)3.97303765
12Muscle hypertrophy of the lower extremities (HP:0008968)3.95975776
13Exercise-induced myalgia (HP:0003738)3.90187554
14Ventricular tachycardia (HP:0004756)3.77284644
15Atrial fibrillation (HP:0005110)3.65252218
16Myoglobinuria (HP:0002913)3.60945525
17Difficulty running (HP:0009046)3.56257866
18Oligomenorrhea (HP:0000876)3.54222518
19Right ventricular cardiomyopathy (HP:0011663)3.52809054
20Insulin-resistant diabetes mellitus (HP:0000831)3.52483250
21Broad metatarsal (HP:0001783)3.51601332
22Increased variability in muscle fiber diameter (HP:0003557)3.45098121
23Calcaneovalgus deformity (HP:0001848)3.44443469
24Focal motor seizures (HP:0011153)3.43101612
25Exercise-induced muscle cramps (HP:0003710)3.42668141
26Hypoplastic ischia (HP:0003175)3.36449191
27Spinal rigidity (HP:0003306)3.36134338
28Primary atrial arrhythmia (HP:0001692)3.34122106
29Ankle contracture (HP:0006466)3.30318508
30Deformed tarsal bones (HP:0008119)3.25261544
31Myotonia (HP:0002486)3.14675623
32Abnormality of the ischium (HP:0003174)3.14242283
33Supraventricular arrhythmia (HP:0005115)3.13360069
34Supraventricular tachycardia (HP:0004755)3.12733069
35Myopathic facies (HP:0002058)3.10847370
36Amelogenesis imperfecta (HP:0000705)3.08463926
37Abnormality of skeletal muscle fiber size (HP:0012084)3.04429402
38Aortic aneurysm (HP:0004942)3.04099443
39Aortic dissection (HP:0002647)2.99892524
40Cerebral aneurysm (HP:0004944)2.91291264
41Absent phalangeal crease (HP:0006109)2.89240035
42Shallow orbits (HP:0000586)2.85598137
43Malignant hyperthermia (HP:0002047)2.85512399
44* Dilated cardiomyopathy (HP:0001644)2.84621422
45Acanthosis nigricans (HP:0000956)2.78509431
46Rhabdomyolysis (HP:0003201)2.78466215
47EMG: myopathic abnormalities (HP:0003458)2.73931301
48Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.71056367
49Popliteal pterygium (HP:0009756)2.68130086
50EMG: neuropathic changes (HP:0003445)2.67769184
51Soft skin (HP:0000977)2.65617472
52Mildly elevated creatine phosphokinase (HP:0008180)2.63865601
53Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.63819718
54Overgrowth (HP:0001548)2.62801175
55Centrally nucleated skeletal muscle fibers (HP:0003687)2.62477007
56Follicular hyperkeratosis (HP:0007502)2.61919182
57Muscle fiber inclusion bodies (HP:0100299)2.60627518
58Atrophic scars (HP:0001075)2.57249040
59Prolonged QT interval (HP:0001657)2.56417023
60Difficulty climbing stairs (HP:0003551)2.55802160
61Hyperglycemia (HP:0003074)2.53613957
62Subaortic stenosis (HP:0001682)2.53340648
63Abnormality of the left ventricular outflow tract (HP:0011103)2.53340648
64Areflexia of lower limbs (HP:0002522)2.44018106
65Cervical subluxation (HP:0003308)2.43045979
66Abnormal finger flexion creases (HP:0006143)2.42780186
67Bundle branch block (HP:0011710)2.42697137
68Fetal akinesia sequence (HP:0001989)2.42664748
69* Scapular winging (HP:0003691)2.37181272
70Bladder diverticulum (HP:0000015)2.32633226
71Fatigable weakness (HP:0003473)2.29824238
72Abnormality of the neuromuscular junction (HP:0003398)2.29824238
73Type 2 muscle fiber atrophy (HP:0003554)2.26716219
74Vertebral arch anomaly (HP:0008438)2.26468397
75Ulnar bowing (HP:0003031)2.25879545
76Limited hip movement (HP:0008800)2.25554584
77Hip contracture (HP:0003273)2.25314504
78Tarsal synostosis (HP:0008368)2.25020402
79Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.23433365
80Round ear (HP:0100830)2.22747359
81Frequent falls (HP:0002359)2.21773131
82Dilatation of the ascending aorta (HP:0005111)2.20539908
83Muscular dystrophy (HP:0003560)2.20366615
84Generalized muscle weakness (HP:0003324)2.19896302
85Ventricular arrhythmia (HP:0004308)2.19125321
86Syncope (HP:0001279)2.18546206
87Broad ribs (HP:0000885)2.16976785
88Fragile skin (HP:0001030)2.16714229
89Aneurysm (HP:0002617)2.15356726
90Rectal prolapse (HP:0002035)2.14612375
91Nemaline bodies (HP:0003798)2.14421721
92Distal arthrogryposis (HP:0005684)2.11249036
93Slender build (HP:0001533)2.10090466
94Acanthocytosis (HP:0001927)2.09583590
95Asymmetric septal hypertrophy (HP:0001670)2.09130244
96Neck muscle weakness (HP:0000467)2.08618609
97Weak cry (HP:0001612)2.07560110
98Bell-shaped thorax (HP:0001591)2.06854227
99Palpitations (HP:0001962)2.05405921
100Synostosis involving bones of the lower limbs (HP:0009138)2.03966718
101Synostosis involving bones of the feet (HP:0009140)2.03966718
102Nonprogressive disorder (HP:0003680)2.02391204
103Distal lower limb muscle weakness (HP:0009053)1.99950809
104Muscle stiffness (HP:0003552)1.98563027
105Mitral valve prolapse (HP:0001634)1.97117866
106Steppage gait (HP:0003376)1.96566606
107Abnormal atrioventricular conduction (HP:0005150)1.96442258
108Bulbar palsy (HP:0001283)1.95623340
109Breech presentation (HP:0001623)1.95279031
110Muscle fiber atrophy (HP:0100295)1.94949273
111Hypoplasia of the iris (HP:0007676)1.94588307
112Wormian bones (HP:0002645)1.94581532
113Bradycardia (HP:0001662)1.93117440
114Abnormality of the foot musculature (HP:0001436)1.91679903
115Wrist flexion contracture (HP:0001239)1.91219327
116Reduced subcutaneous adipose tissue (HP:0003758)1.90176103
117Hypoalphalipoproteinemia (HP:0003233)1.89783839
118Atrioventricular block (HP:0001678)1.88891258
119Ulnar deviation of finger (HP:0009465)1.88840564
120Metatarsus adductus (HP:0001840)1.88660618
121Vascular tortuosity (HP:0004948)1.88509795
122Aplasia of the musculature (HP:0100854)1.88161740
123Foot dorsiflexor weakness (HP:0009027)1.88109833
124Insulin resistance (HP:0000855)1.87927532
125Facial diplegia (HP:0001349)1.87636741
126Arterial tortuosity (HP:0005116)1.87081382
127Limb-girdle muscle weakness (HP:0003325)1.84803512
128Neonatal short-limb short stature (HP:0008921)1.83139337
129Toxemia of pregnancy (HP:0100603)1.80624880
130Heart block (HP:0012722)1.79811046
131Blue sclerae (HP:0000592)1.77475584
132Hypoglycemic coma (HP:0001325)1.76155382
133Distal lower limb amyotrophy (HP:0008944)1.76036568
134Rimmed vacuoles (HP:0003805)1.75027961
135Abnormality of dentin (HP:0010299)1.73681539
136Ketoacidosis (HP:0001993)1.71191967
137Genu recurvatum (HP:0002816)1.70799195
138Venous abnormality (HP:0002624)1.70582179
139Decreased subcutaneous fat (HP:0001002)1.70326046
140Gowers sign (HP:0003391)1.68820400
141Hyperextensible skin (HP:0000974)1.68056585

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.23907530
2OBSCN3.86757675
3SIK13.37728422
4CAMK1D3.28870390
5TRIB33.16735677
6PIK3CA2.86755711
7LATS12.84588894
8LMTK22.64458897
9DDR22.63947957
10CAMK1G2.46814964
11PHKG12.46043134
12PHKG22.46043134
13PDK32.38009108
14PDK42.38009108
15DMPK2.35343505
16STK38L2.15196429
17PDGFRA1.98689183
18BCKDK1.76725799
19EPHA31.75931688
20LATS21.74372968
21NLK1.72593456
22MYLK1.60694894
23ZAK1.60563956
24FRK1.55882673
25PRKAA21.50425556
26PKN21.40257967
27INSRR1.36129762
28TGFBR21.35660921
29MAP2K21.33403198
30PDK21.32161763
31TRPM71.31972136
32EPHB21.30672284
33PINK11.29429329
34NEK91.21457083
35ACVR1B1.19616055
36RIPK11.19586948
37PAK31.13931495
38STK241.10668772
39PRKAA11.08100190
40ROCK11.07248992
41MAP3K61.06488827
42CDC42BPA1.01178928
43GRK70.99725966
44MUSK0.98245719
45FGFR20.96068552
46KSR20.93404681
47MAP3K40.93377788
48RET0.91457942
49PRKD30.89391526
50PRKD10.87588702
51PAK60.85907631
52FER0.85810475
53PDPK10.83591924
54BMPR1B0.81988063
55MAPKAPK30.80640527
56MARK10.79922651
57MAP3K30.78480505
58STK30.78151166
59FGFR30.76940801
60TIE10.75322043
61PDGFRB0.74979274
62STK380.71659760
63MAPK70.70512296
64PAK20.68741138
65MAP3K20.68552563
66ERBB30.66846654
67PRKCH0.64963335
68MTOR0.64747345
69MAP2K10.62394544
70ADRBK10.62305844
71ILK0.61002908
72CAMK2D0.60055477
73CDK90.57925361
74PTK2B0.56375939
75JAK10.54921074
76WNK10.53578636
77PIK3CG0.51753574
78MAP2K40.50915659
79EEF2K0.50609017
80PRKCE0.49825107
81MET0.49598604
82TGFBR10.49258205
83SGK20.49069922
84SGK30.47118623
85CAMK2G0.47046112
86FLT30.42961550
87NEK10.42523596
88NUAK10.42314322
89MAP3K50.42288373
90MAP3K70.41065773
91CAMK2B0.40673165
92AKT20.40453755
93EIF2AK20.39757814
94CAMK10.39621758
95MARK20.38709297
96PRKACG0.38092017
97LIMK10.37762706
98ROCK20.37389932
99PRKD20.36665645
100MST1R0.36098574
101MELK0.35483464
102IGF1R0.35236781
103GRK50.33396183
104FGFR10.32745301
105NEK20.30990073
106PTK20.30605350
107RPS6KB10.29457277
108PRKACA0.29178836
109PRKG10.28835442
110AKT30.28711222
111PKN10.28126880
112MAPK120.27837328
113MAP2K30.27775042
114MAPK110.27560882
115SGK10.26916378
116CAMK40.26876481
117GSK3A0.26414853
118CAMK2A0.26299046
119PLK20.26187693
120NME10.26041962
121MOS0.25616953
122EIF2AK30.23861347
123MAPKAPK50.23819476
124DAPK30.22550040
125DAPK20.21979075
126CSNK1A1L0.21589192
127KIT0.21421495
128PRKG20.20915972
129CCNB10.20460307
130MAPK40.19142224
131PRKACB0.17659677
132STK110.16782587
133NTRK10.15887757
134TAF10.14213227
135IRAK30.13354694
136ABL10.10464932
137MAPK30.09405806
138CSNK1D0.09035016
139RPS6KA30.08946332

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004006.35452215
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.32998062
3Propanoate metabolism_Homo sapiens_hsa006403.49796005
4* Dilated cardiomyopathy_Homo sapiens_hsa054143.06300715
5* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.03882137
6Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.97476318
7Fatty acid biosynthesis_Homo sapiens_hsa000612.57969489
8Fatty acid metabolism_Homo sapiens_hsa012122.53423972
9PPAR signaling pathway_Homo sapiens_hsa033202.48037613
10ECM-receptor interaction_Homo sapiens_hsa045122.47281396
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.43700489
12* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.41874252
13Fatty acid degradation_Homo sapiens_hsa000712.38064386
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.32335541
15Phototransduction_Homo sapiens_hsa047442.08636194
16Cardiac muscle contraction_Homo sapiens_hsa042601.92800241
17Sphingolipid metabolism_Homo sapiens_hsa006001.92438471
18Dorso-ventral axis formation_Homo sapiens_hsa043201.89801948
19Focal adhesion_Homo sapiens_hsa045101.88644429
20AMPK signaling pathway_Homo sapiens_hsa041521.78082946
21Insulin signaling pathway_Homo sapiens_hsa049101.61305558
22Adipocytokine signaling pathway_Homo sapiens_hsa049201.58997920
23Insulin resistance_Homo sapiens_hsa049311.58378250
24Pyruvate metabolism_Homo sapiens_hsa006201.47183140
25Protein digestion and absorption_Homo sapiens_hsa049741.43430068
26Carbon metabolism_Homo sapiens_hsa012001.38458775
27Glucagon signaling pathway_Homo sapiens_hsa049221.35477964
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.31558954
29Adherens junction_Homo sapiens_hsa045201.29784032
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27918617
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.21078218
32cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17910060
33Glycerolipid metabolism_Homo sapiens_hsa005611.16978653
34Type II diabetes mellitus_Homo sapiens_hsa049301.14253162
35Longevity regulating pathway - mammal_Homo sapiens_hsa042111.12089902
36Taste transduction_Homo sapiens_hsa047421.10125035
37Morphine addiction_Homo sapiens_hsa050321.08741641
38Amoebiasis_Homo sapiens_hsa051461.02520097
39Proteoglycans in cancer_Homo sapiens_hsa052051.02066302
40Renin secretion_Homo sapiens_hsa049241.01151872
41GABAergic synapse_Homo sapiens_hsa047271.00601791
42Nicotine addiction_Homo sapiens_hsa050330.98887181
43* Viral myocarditis_Homo sapiens_hsa054160.98104680
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98078952
45Arginine and proline metabolism_Homo sapiens_hsa003300.96117793
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.95923479
47Gastric acid secretion_Homo sapiens_hsa049710.95170812
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90637631
49Lysine degradation_Homo sapiens_hsa003100.90588285
50Butanoate metabolism_Homo sapiens_hsa006500.89677559
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86696465
52TGF-beta signaling pathway_Homo sapiens_hsa043500.86134034
53Histidine metabolism_Homo sapiens_hsa003400.82384760
54beta-Alanine metabolism_Homo sapiens_hsa004100.81671050
55Ovarian steroidogenesis_Homo sapiens_hsa049130.80450244
56PI3K-Akt signaling pathway_Homo sapiens_hsa041510.80085835
57Gap junction_Homo sapiens_hsa045400.76820134
58Tight junction_Homo sapiens_hsa045300.75673851
59Starch and sucrose metabolism_Homo sapiens_hsa005000.74430835
60Oxytocin signaling pathway_Homo sapiens_hsa049210.74123988
61cAMP signaling pathway_Homo sapiens_hsa040240.71919264
62Circadian rhythm_Homo sapiens_hsa047100.71804845
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70833058
64Salivary secretion_Homo sapiens_hsa049700.70395255
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70363254
66HIF-1 signaling pathway_Homo sapiens_hsa040660.70158465
67mTOR signaling pathway_Homo sapiens_hsa041500.69699951
68Melanoma_Homo sapiens_hsa052180.68932237
69VEGF signaling pathway_Homo sapiens_hsa043700.65095498
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64403915
71Hippo signaling pathway_Homo sapiens_hsa043900.64041597
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64039084
73Small cell lung cancer_Homo sapiens_hsa052220.62941865
74Fatty acid elongation_Homo sapiens_hsa000620.62423789
75Parkinsons disease_Homo sapiens_hsa050120.61689831
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.61538531
77Glutamatergic synapse_Homo sapiens_hsa047240.61157028
78Calcium signaling pathway_Homo sapiens_hsa040200.60777806
79Basal cell carcinoma_Homo sapiens_hsa052170.60523973
80Long-term potentiation_Homo sapiens_hsa047200.59433291
81Alzheimers disease_Homo sapiens_hsa050100.58979553
82GnRH signaling pathway_Homo sapiens_hsa049120.58421596
83Insulin secretion_Homo sapiens_hsa049110.58266358
84N-Glycan biosynthesis_Homo sapiens_hsa005100.57543321
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56517512
86Bile secretion_Homo sapiens_hsa049760.55330943
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54113041
88Renal cell carcinoma_Homo sapiens_hsa052110.53874320
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.53821326
90ABC transporters_Homo sapiens_hsa020100.53692054
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.53504269
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51240060
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51124538
94Tyrosine metabolism_Homo sapiens_hsa003500.51012105
95MicroRNAs in cancer_Homo sapiens_hsa052060.49504915
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48824479
97Oxidative phosphorylation_Homo sapiens_hsa001900.48423535
98Pancreatic secretion_Homo sapiens_hsa049720.48191582
99FoxO signaling pathway_Homo sapiens_hsa040680.48113034
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47978122
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47908737
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47354107
103Wnt signaling pathway_Homo sapiens_hsa043100.46593682
104Melanogenesis_Homo sapiens_hsa049160.46534120
105Estrogen signaling pathway_Homo sapiens_hsa049150.46186454
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46150667
107Fat digestion and absorption_Homo sapiens_hsa049750.45748504
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44748109
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44299814
110Platelet activation_Homo sapiens_hsa046110.44243072
111Endometrial cancer_Homo sapiens_hsa052130.43448060
112Hedgehog signaling pathway_Homo sapiens_hsa043400.43212390
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42906122
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42830308
115Serotonergic synapse_Homo sapiens_hsa047260.42142408
116Pathways in cancer_Homo sapiens_hsa052000.42090815
117Tryptophan metabolism_Homo sapiens_hsa003800.41397618
118Cholinergic synapse_Homo sapiens_hsa047250.40998987
119Phenylalanine metabolism_Homo sapiens_hsa003600.40672259
120Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40139161
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40082010
122Galactose metabolism_Homo sapiens_hsa000520.39481967
123Peroxisome_Homo sapiens_hsa041460.38784274
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38424045
125Axon guidance_Homo sapiens_hsa043600.38276595
126Huntingtons disease_Homo sapiens_hsa050160.37906455
127Thyroid hormone synthesis_Homo sapiens_hsa049180.36613243
128Circadian entrainment_Homo sapiens_hsa047130.36091993
129Glycosaminoglycan degradation_Homo sapiens_hsa005310.36027948
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.35951633
131Vitamin B6 metabolism_Homo sapiens_hsa007500.35726548
132Glioma_Homo sapiens_hsa052140.35068377
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34703144
134Ras signaling pathway_Homo sapiens_hsa040140.34427665
135Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34071049
136Nitrogen metabolism_Homo sapiens_hsa009100.33286253
137Rap1 signaling pathway_Homo sapiens_hsa040150.33075999
138Colorectal cancer_Homo sapiens_hsa052100.32942168

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