SGCE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the epsilon member of the sarcoglycan family. Sarcoglycans are transmembrane proteins that are components of the dystrophin-glycoprotein complex, which link the actin cytoskeleton to the extracellular matrix. Unlike other family members which are predominantly expressed in striated muscle, the epsilon sarcoglycan is more broadly expressed. Mutations in this gene are associated with myoclonus-dystonia syndrome. This gene is imprinted, with preferential expression from the paternal allele. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A pseudogene associated with this gene is located on chromosome 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)6.10350109
2axon ensheathment in central nervous system (GO:0032291)6.10350109
3peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.98074161
4myelination (GO:0042552)3.92192686
5ensheathment of neurons (GO:0007272)3.86221511
6axon ensheathment (GO:0008366)3.86221511
7negative regulation of protein localization to cell surface (GO:2000009)3.86091088
8fatty acid elongation (GO:0030497)3.84093057
9limb bud formation (GO:0060174)3.79480017
10bone trabecula formation (GO:0060346)3.71057134
11long-chain fatty acid biosynthetic process (GO:0042759)3.66297748
12water-soluble vitamin biosynthetic process (GO:0042364)3.49620026
13presynaptic membrane assembly (GO:0097105)3.40380318
14presynaptic membrane organization (GO:0097090)3.25740136
15oligodendrocyte differentiation (GO:0048709)3.24526516
16myelination in peripheral nervous system (GO:0022011)3.21086934
17peripheral nervous system axon ensheathment (GO:0032292)3.21086934
18negative regulation of neurotransmitter transport (GO:0051589)3.19332197
19cerebral cortex radially oriented cell migration (GO:0021799)3.17982495
20extracellular fibril organization (GO:0043206)3.05378373
21lateral sprouting from an epithelium (GO:0060601)3.00305139
22negative regulation of axon extension involved in axon guidance (GO:0048843)2.99265948
23photoreceptor cell differentiation (GO:0046530)2.87779501
24eye photoreceptor cell differentiation (GO:0001754)2.87779501
25negative regulation of neurotransmitter secretion (GO:0046929)2.87419607
26startle response (GO:0001964)2.86540039
27dermatan sulfate biosynthetic process (GO:0030208)2.83813170
28negative regulation of JUN kinase activity (GO:0043508)2.82370633
29negative regulation of axon guidance (GO:1902668)2.80974666
30response to redox state (GO:0051775)2.80571079
31extracellular regulation of signal transduction (GO:1900115)2.79972239
32extracellular negative regulation of signal transduction (GO:1900116)2.79972239
33intraciliary transport (GO:0042073)2.78938486
34estrogen biosynthetic process (GO:0006703)2.77225202
35dermatan sulfate metabolic process (GO:0030205)2.75918538
36response to pheromone (GO:0019236)2.73806466
37L-amino acid import (GO:0043092)2.71566978
38positive regulation of synapse assembly (GO:0051965)2.71040035
39sequestering of extracellular ligand from receptor (GO:0035581)2.70532044
40protein heterotrimerization (GO:0070208)2.70447533
41positive regulation of oligodendrocyte differentiation (GO:0048714)2.68989208
42neuron cell-cell adhesion (GO:0007158)2.68750385
43mesenchymal-epithelial cell signaling (GO:0060638)2.64153934
44positive regulation of action potential (GO:0045760)2.64141093
45regulation of glucokinase activity (GO:0033131)2.62868744
46regulation of hexokinase activity (GO:1903299)2.62868744
47cullin deneddylation (GO:0010388)2.61851817
48neuron remodeling (GO:0016322)2.61778840
49regulation of pigment cell differentiation (GO:0050932)2.60435510
50negative regulation of axon extension (GO:0030517)2.60291053
51adhesion of symbiont to host cell (GO:0044650)2.56166426
52virion attachment to host cell (GO:0019062)2.56166426
53dendritic spine morphogenesis (GO:0060997)2.54955376
54retina vasculature morphogenesis in camera-type eye (GO:0061299)2.54674546
55import into cell (GO:0098657)2.54395221
56mechanosensory behavior (GO:0007638)2.52946578
57negative regulation of myoblast differentiation (GO:0045662)2.52523311
58chondroitin sulfate catabolic process (GO:0030207)2.51984225
59regulation of collateral sprouting (GO:0048670)2.51152411
60apical protein localization (GO:0045176)2.50198109
61astrocyte development (GO:0014002)2.49606033
62protein deneddylation (GO:0000338)2.48356776
63auditory behavior (GO:0031223)2.48019457
64glomerular filtration (GO:0003094)2.46021166
65lipid particle organization (GO:0034389)2.45203975
66cellular response to epinephrine stimulus (GO:0071872)2.45065320
67negative regulation of hormone biosynthetic process (GO:0032353)2.44178067
68peptidyl-tyrosine autophosphorylation (GO:0038083)2.43632903
69platelet dense granule organization (GO:0060155)2.42736331
70positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.42157891
71cell proliferation involved in kidney development (GO:0072111)2.42060567
72glycerophospholipid catabolic process (GO:0046475)2.41671479
73response to epinephrine (GO:0071871)2.41405859
74membrane assembly (GO:0071709)2.39425487
75blood vessel maturation (GO:0001955)2.38412119
76positive regulation of smooth muscle cell migration (GO:0014911)2.37454908
77regulation of non-canonical Wnt signaling pathway (GO:2000050)2.36411885
78amino acid import (GO:0043090)2.35509823
79cilium morphogenesis (GO:0060271)2.35435223
80negative chemotaxis (GO:0050919)2.35367327
81positive regulation of actin filament depolymerization (GO:0030836)2.34189957
82axonal fasciculation (GO:0007413)2.34133621
83extracellular matrix assembly (GO:0085029)2.33306980
84response to monoamine (GO:0071867)2.32726221
85response to catecholamine (GO:0071869)2.32726221
86mannosylation (GO:0097502)2.31651762
87short-term memory (GO:0007614)2.31460463
88endocardial cushion morphogenesis (GO:0003203)2.31333442
89protein neddylation (GO:0045116)2.31198991
90smooth muscle tissue development (GO:0048745)2.30994999
91mesenchymal cell differentiation involved in renal system development (GO:2001012)2.29863547
92mesenchymal cell differentiation involved in kidney development (GO:0072161)2.29863547
93cell differentiation involved in metanephros development (GO:0072202)2.29687589
94retinal ganglion cell axon guidance (GO:0031290)2.28812557
95collagen fibril organization (GO:0030199)2.28786376
96response to auditory stimulus (GO:0010996)2.28240817
97mesenchymal cell differentiation (GO:0048762)2.27244709
98regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.26737590
99mesenchymal cell proliferation (GO:0010463)2.26672359
100cholesterol biosynthetic process (GO:0006695)2.25668338
101regulation of type B pancreatic cell apoptotic process (GO:2000674)2.25498903
102neuron recognition (GO:0008038)2.25428209
103negative regulation of axonogenesis (GO:0050771)2.25413595
104glial cell development (GO:0021782)2.25225900
105transmission of nerve impulse (GO:0019226)2.24962606
106negative regulation of membrane potential (GO:0045837)2.24318652
107negative regulation of synaptic transmission, GABAergic (GO:0032229)2.23119410
108pyrimidine nucleobase catabolic process (GO:0006208)2.22800234
109cyclic nucleotide catabolic process (GO:0009214)2.22238360
110nonmotile primary cilium assembly (GO:0035058)2.21989768
111cellular response to catecholamine stimulus (GO:0071870)2.21980177
112cellular response to monoamine stimulus (GO:0071868)2.21980177
113regulation of axon extension involved in axon guidance (GO:0048841)2.21681075
114substantia nigra development (GO:0021762)2.21448761
115regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.21232046
116response to gravity (GO:0009629)2.21030246
117glomerular basement membrane development (GO:0032836)2.20907533
118calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.20246696
119fibril organization (GO:0097435)2.19284337
120regulation of axon guidance (GO:1902667)2.18973171
121regulation of somitogenesis (GO:0014807)2.18486855
122vascular smooth muscle contraction (GO:0014829)2.17565448
123protein localization to cilium (GO:0061512)2.17006350
124limb development (GO:0060173)2.15235395
125appendage development (GO:0048736)2.15235395
126renal tubule morphogenesis (GO:0061333)2.13021203
127detection of calcium ion (GO:0005513)2.12640228
128nephron tubule morphogenesis (GO:0072078)2.12639848
129nephron epithelium morphogenesis (GO:0072088)2.12639848
130negative regulation of hormone metabolic process (GO:0032351)2.10564574
131inositol phosphate catabolic process (GO:0071545)2.10319176
132nucleobase catabolic process (GO:0046113)2.08906423
133positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.08807641
134axon extension involved in axon guidance (GO:0048846)2.06633810
135neuron projection extension involved in neuron projection guidance (GO:1902284)2.06633810
136peptidyl-cysteine modification (GO:0018198)2.03514848
137glycosphingolipid biosynthetic process (GO:0006688)2.03374152
138chondrocyte proliferation (GO:0035988)2.03065333
139somite development (GO:0061053)2.02871743
140Leydig cell differentiation (GO:0033327)2.02410896
141negative regulation of neurological system process (GO:0031645)2.00591605
142smoothened signaling pathway (GO:0007224)1.99456290
143negative regulation of cytosolic calcium ion concentration (GO:0051481)1.99367198
144regulation of ER to Golgi vesicle-mediated transport (GO:0060628)1.97939940
145phosphorylated carbohydrate dephosphorylation (GO:0046838)1.97811435
146inositol phosphate dephosphorylation (GO:0046855)1.97811435
147regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)1.97706262
148cornea development in camera-type eye (GO:0061303)1.97448502
149protein complex biogenesis (GO:0070271)1.96253433
150kidney morphogenesis (GO:0060993)1.96006920
151regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022351.95954516
152adrenal gland development (GO:0030325)1.95692276
153C4-dicarboxylate transport (GO:0015740)1.95040348
154regulation of vascular endothelial growth factor signaling pathway (GO:1900746)1.92475096
155dorsal/ventral axis specification (GO:0009950)1.92342591
156tonic smooth muscle contraction (GO:0014820)1.91460177
157retinal cone cell development (GO:0046549)1.91361169
158sterol biosynthetic process (GO:0016126)1.89980024
159regulation of male gonad development (GO:2000018)1.89643122
160phasic smooth muscle contraction (GO:0014821)1.89465937
161negative regulation of activin receptor signaling pathway (GO:0032926)1.89246935
162cilium organization (GO:0044782)1.89029304
163regulation of secondary heart field cardioblast proliferation (GO:0003266)1.87105374
164regulation of cardioblast proliferation (GO:0003264)1.87105374
165positive regulation of protein autophosphorylation (GO:0031954)1.86505430
166regulation of integrin-mediated signaling pathway (GO:2001044)1.85981704
167cilium assembly (GO:0042384)1.84669377
168toxin metabolic process (GO:0009404)1.84522250
169respiratory chain complex IV assembly (GO:0008535)1.84221742
170cardiac right ventricle morphogenesis (GO:0003215)1.84036413
171cytochrome complex assembly (GO:0017004)1.83895572
172cellular ketone body metabolic process (GO:0046950)1.83663273
173positive regulation of mitochondrial fission (GO:0090141)1.83499402
174type B pancreatic cell proliferation (GO:0044342)1.83011632
175C-terminal protein amino acid modification (GO:0018410)1.82963590
176neuronal action potential propagation (GO:0019227)1.82836321
177artery smooth muscle contraction (GO:0014824)1.82484246
178synapse assembly (GO:0007416)1.81971866
179determination of left/right symmetry (GO:0007368)1.81435633
180melanosome transport (GO:0032402)1.81398407

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.90822028
2EED_16625203_ChIP-ChIP_MESCs_Mouse2.79132559
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.71490639
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.63531698
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.62669927
6EZH2_22144423_ChIP-Seq_EOC_Human2.59559177
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.58374754
8* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51342438
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.47065080
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.40699807
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40588574
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37257995
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.34575278
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.34575278
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24615682
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.20497327
17* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.20002234
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13910870
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.12330268
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.06990441
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.06952156
22SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.04298674
23* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.00612463
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00409471
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.98654602
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.91283895
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.88213344
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.87254290
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.86306824
30TAF15_26573619_Chip-Seq_HEK293_Human1.85491070
31ZNF274_21170338_ChIP-Seq_K562_Hela1.84446915
32OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.80491614
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.80436309
34P300_19829295_ChIP-Seq_ESCs_Human1.80365122
35AR_21572438_ChIP-Seq_LNCaP_Human1.80115535
36* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79955745
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.79446887
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79315765
39* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.78461056
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77036943
41* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76689751
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73914635
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.71134790
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70637064
45WT1_19549856_ChIP-ChIP_CCG9911_Human1.57683950
46FUS_26573619_Chip-Seq_HEK293_Human1.54514122
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53225155
48ER_23166858_ChIP-Seq_MCF-7_Human1.52671899
49EP300_21415370_ChIP-Seq_HL-1_Mouse1.52188593
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.49278953
51SMAD4_21799915_ChIP-Seq_A2780_Human1.47607710
52ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46682677
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46453191
54RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.40487370
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39940565
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36480593
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36018722
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36018722
59DROSHA_22980978_ChIP-Seq_HELA_Human1.35727275
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35120233
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32726347
62RNF2_27304074_Chip-Seq_NSC_Mouse1.31855820
63HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.31154644
64TP53_18474530_ChIP-ChIP_U2OS_Human1.31125586
65HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31071940
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29434249
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28354708
68EWS_26573619_Chip-Seq_HEK293_Human1.27072978
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26833980
70BCAT_22108803_ChIP-Seq_LS180_Human1.24943719
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24879003
72KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.24448427
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23989027
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23552357
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.23489097
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21675991
77CBP_20019798_ChIP-Seq_JUKART_Human1.20843354
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20843354
79* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19931771
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.19784965
81TBX3_20139965_ChIP-Seq_MESCs_Mouse1.19426227
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.19381893
83TBX3_20139965_ChIP-Seq_ESCs_Mouse1.19102446
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17085898
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16460793
86STAT3_23295773_ChIP-Seq_U87_Human1.14001391
87EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13139689
88VDR_22108803_ChIP-Seq_LS180_Human1.12254233
89* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11797572
90RUNX2_22187159_ChIP-Seq_PCA_Human1.10291451
91NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09967056
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09460966
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09428975
94NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08837859
95E2F1_18555785_Chip-Seq_ESCs_Mouse1.08652802
96BRD4_25478319_ChIP-Seq_HGPS_Human1.07949277
97TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07715083
98AR_25329375_ChIP-Seq_VCAP_Human1.07230564
99CMYC_18555785_Chip-Seq_ESCs_Mouse1.07170541
100SOX9_26525672_Chip-Seq_HEART_Mouse1.06994323
101ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06871354
102SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06786793
103TCF4_22108803_ChIP-Seq_LS180_Human1.06179481
104TAL1_26923725_Chip-Seq_HPCs_Mouse1.04952862
105PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04473772
106ELK1_19687146_ChIP-ChIP_HELA_Human1.03628348
107CJUN_26792858_Chip-Seq_BT549_Human1.02803739
108TCF4_23295773_ChIP-Seq_U87_Human1.02222710
109RING1B_27294783_Chip-Seq_ESCs_Mouse1.01673867
110IGF1R_20145208_ChIP-Seq_DFB_Human1.01481115
111P53_22387025_ChIP-Seq_ESCs_Mouse1.01470551
112* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00565876
113KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.00145816
114SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.00047611
115ARNT_22903824_ChIP-Seq_MCF-7_Human0.99486554
116JUN_21703547_ChIP-Seq_K562_Human0.97714559
117SOX2_21211035_ChIP-Seq_LN229_Gbm0.97021293
118LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95465896
119KDM2B_26808549_Chip-Seq_REH_Human0.95263626
120CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.95245868
121TP53_16413492_ChIP-PET_HCT116_Human0.95068763
122SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94900475
123STAT3_18555785_Chip-Seq_ESCs_Mouse0.94809346
124FLI1_27457419_Chip-Seq_LIVER_Mouse0.93889985
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93810166
126P300_18555785_Chip-Seq_ESCs_Mouse0.92995077

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.53900362
2MP0005503_abnormal_tendon_morphology3.92929759
3MP0005171_absent_coat_pigmentation3.33481322
4MP0009780_abnormal_chondrocyte_physiolo2.77454826
5MP0003950_abnormal_plasma_membrane2.52212550
6MP0004272_abnormal_basement_membrane2.43007389
7MP0000920_abnormal_myelination2.32232016
8MP0002837_dystrophic_cardiac_calcinosis2.29340568
9MP0003880_abnormal_central_pattern2.23122729
10MP0003136_yellow_coat_color2.20086090
11MP0000566_synostosis2.12372856
12MP0005275_abnormal_skin_tensile1.97206563
13MP0002938_white_spotting1.81111501
14MP0002108_abnormal_muscle_morphology1.77127176
15MP0000778_abnormal_nervous_system1.76354384
16MP0001984_abnormal_olfaction1.73145947
17MP0006072_abnormal_retinal_apoptosis1.72688508
18MP0001486_abnormal_startle_reflex1.69497891
19MP0009250_abnormal_appendicular_skeleto1.68318604
20MP0003011_delayed_dark_adaptation1.68009598
21MP0001905_abnormal_dopamine_level1.65770773
22MP0001188_hyperpigmentation1.65728763
23MP0001529_abnormal_vocalization1.62114032
24* MP0003122_maternal_imprinting1.61469889
25MP0002102_abnormal_ear_morphology1.60411410
26MP0004134_abnormal_chest_morphology1.59599440
27MP0004742_abnormal_vestibular_system1.58251202
28MP0010368_abnormal_lymphatic_system1.57869244
29MP0001958_emphysema1.57608556
30MP0002909_abnormal_adrenal_gland1.56274067
31MP0003195_calcinosis1.54208804
32MP0005623_abnormal_meninges_morphology1.52165804
33MP0002736_abnormal_nociception_after1.52003391
34MP0009384_cardiac_valve_regurgitation1.50308679
35MP0003279_aneurysm1.49651538
36MP0003690_abnormal_glial_cell1.48112421
37MP0005508_abnormal_skeleton_morphology1.47975591
38MP0002272_abnormal_nervous_system1.40070494
39MP0003385_abnormal_body_wall1.38438083
40MP0004885_abnormal_endolymph1.35736264
41MP0001177_atelectasis1.35011415
42MP0002638_abnormal_pupillary_reflex1.33461679
43MP0002928_abnormal_bile_duct1.32902242
44MP0005084_abnormal_gallbladder_morpholo1.32777133
45MP0003634_abnormal_glial_cell1.31131585
46MP0005379_endocrine/exocrine_gland_phen1.30428063
47MP0004142_abnormal_muscle_tone1.25804066
48MP0000013_abnormal_adipose_tissue1.25721348
49MP0010030_abnormal_orbit_morphology1.25640069
50MP0001968_abnormal_touch/_nociception1.25039471
51MP0003283_abnormal_digestive_organ1.24735662
52MP0005257_abnormal_intraocular_pressure1.23487797
53MP0001299_abnormal_eye_distance/1.22196159
54MP0008789_abnormal_olfactory_epithelium1.22084373
55MP0004859_abnormal_synaptic_plasticity1.20382469
56MP0005645_abnormal_hypothalamus_physiol1.19605472
57* MP0002064_seizures1.19518344
58MP0002295_abnormal_pulmonary_circulatio1.19038093
59MP0003635_abnormal_synaptic_transmissio1.18632236
60MP0000372_irregular_coat_pigmentation1.17891578
61MP0002572_abnormal_emotion/affect_behav1.17736478
62MP0000049_abnormal_middle_ear1.17532278
63MP0009745_abnormal_behavioral_response1.17409233
64MP0005646_abnormal_pituitary_gland1.14961933
65MP0009697_abnormal_copulation1.13708487
66MP0003890_abnormal_embryonic-extraembry1.12495968
67MP0002233_abnormal_nose_morphology1.12400916
68MP0000639_abnormal_adrenal_gland1.11887477
69MP0005367_renal/urinary_system_phenotyp1.11765902
70MP0000516_abnormal_urinary_system1.11765902
71MP0000026_abnormal_inner_ear1.11300200
72MP0003937_abnormal_limbs/digits/tail_de1.10083366
73MP0002751_abnormal_autonomic_nervous1.09514794
74MP0001879_abnormal_lymphatic_vessel1.09113945
75MP0004145_abnormal_muscle_electrophysio1.08915832
76MP0000749_muscle_degeneration1.07167525
77MP0005409_darkened_coat_color1.07092374
78MP0001502_abnormal_circadian_rhythm1.07021934
79MP0001963_abnormal_hearing_physiology1.06874974
80MP0000751_myopathy1.05956282
81MP0003123_paternal_imprinting1.05469134
82MP0002734_abnormal_mechanical_nocicepti1.04712970
83MP0005551_abnormal_eye_electrophysiolog1.04367927
84MP0002067_abnormal_sensory_capabilities1.04098003
85MP0002063_abnormal_learning/memory/cond1.03989339
86MP0002090_abnormal_vision1.03279225
87MP0002282_abnormal_trachea_morphology1.03202047
88MP0002184_abnormal_innervation1.02986144
89MP0002234_abnormal_pharynx_morphology1.01890289
90MP0005595_abnormal_vascular_smooth0.99933843
91MP0004270_analgesia0.99275924
92MP0003787_abnormal_imprinting0.98032946
93MP0005248_abnormal_Harderian_gland0.97798610
94MP0000762_abnormal_tongue_morphology0.97506334
95MP0005187_abnormal_penis_morphology0.97435281
96MP0002876_abnormal_thyroid_physiology0.97421347
97MP0003942_abnormal_urinary_system0.95315559
98MP0000631_abnormal_neuroendocrine_gland0.94665991
99MP0008775_abnormal_heart_ventricle0.94663278
100MP0005388_respiratory_system_phenotype0.94048437
101MP0002133_abnormal_respiratory_system0.94048437
102MP0002557_abnormal_social/conspecific_i0.93428268
103MP0006054_spinal_hemorrhage0.92846492
104MP0002752_abnormal_somatic_nervous0.91940314
105MP0001270_distended_abdomen0.91484667
106MP0000647_abnormal_sebaceous_gland0.91091603
107MP0001542_abnormal_bone_strength0.89766220
108MP0000538_abnormal_urinary_bladder0.89498597
109MP0006292_abnormal_olfactory_placode0.89115274
110MP0002249_abnormal_larynx_morphology0.89052612
111MP0002882_abnormal_neuron_morphology0.88915651
112MP0003938_abnormal_ear_development0.88771432
113MP0003119_abnormal_digestive_system0.87805918
114MP0000955_abnormal_spinal_cord0.87660010
115MP0005499_abnormal_olfactory_system0.87323882
116MP0005394_taste/olfaction_phenotype0.87323882
117MP0005386_behavior/neurological_phenoty0.87010180
118MP0004924_abnormal_behavior0.87010180
119MP0004133_heterotaxia0.86810476
120MP0000163_abnormal_cartilage_morphology0.86153213
121* MP0003121_genomic_imprinting0.85174670
122* MP0009046_muscle_twitch0.84230934
123MP0000462_abnormal_digestive_system0.82165147
124MP0004215_abnormal_myocardial_fiber0.81966416
125MP0005253_abnormal_eye_physiology0.81551154
126MP0001756_abnormal_urination0.80319176
127MP0003646_muscle_fatigue0.80056938
128MP0003755_abnormal_palate_morphology0.79926277
129MP0005220_abnormal_exocrine_pancreas0.79831774
130MP0006276_abnormal_autonomic_nervous0.79587366
131MP0010386_abnormal_urinary_bladder0.79439401
132MP0002163_abnormal_gland_morphology0.79186093
133MP0002932_abnormal_joint_morphology0.78985711
134MP0010234_abnormal_vibrissa_follicle0.77813491
135MP0006138_congestive_heart_failure0.77365818
136MP0003632_abnormal_nervous_system0.75674342
137MP0005195_abnormal_posterior_eye0.75105202
138MP0001485_abnormal_pinna_reflex0.74703747
139MP0005423_abnormal_somatic_nervous0.74491846
140MP0002116_abnormal_craniofacial_bone0.74167177
141MP0004036_abnormal_muscle_relaxation0.74089568
142MP0001986_abnormal_taste_sensitivity0.73969850
143MP0000534_abnormal_ureter_morphology0.73842967

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)3.61298009
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.42981384
3Degeneration of the lateral corticospinal tracts (HP:0002314)3.42981384
4Broad metatarsal (HP:0001783)3.08525257
5Bell-shaped thorax (HP:0001591)2.91888523
6Cutaneous melanoma (HP:0012056)2.88426126
7Aplasia involving bones of the upper limbs (HP:0009823)2.78381056
8Aplasia of the phalanges of the hand (HP:0009802)2.78381056
9Aplasia involving bones of the extremities (HP:0009825)2.78381056
10Delayed gross motor development (HP:0002194)2.77578835
11Septo-optic dysplasia (HP:0100842)2.72743225
12White forelock (HP:0002211)2.71807743
13Patchy hypopigmentation of hair (HP:0011365)2.65406139
14Split foot (HP:0001839)2.63321042
15Neurofibrillary tangles (HP:0002185)2.62059388
16Abnormality of dentin (HP:0010299)2.61019635
17Adrenal hypoplasia (HP:0000835)2.55616752
18Intestinal atresia (HP:0011100)2.47450635
19Increased corneal curvature (HP:0100692)2.46357687
20Keratoconus (HP:0000563)2.46357687
21Retinal dysplasia (HP:0007973)2.42210027
22Pancreatic fibrosis (HP:0100732)2.41661957
23Protrusio acetabuli (HP:0003179)2.37876941
24Vascular tortuosity (HP:0004948)2.36614976
25Soft skin (HP:0000977)2.35947298
26Aortic dissection (HP:0002647)2.35758247
27Narrow nasal bridge (HP:0000446)2.33486713
28Wrist flexion contracture (HP:0001239)2.32691047
29Follicular hyperkeratosis (HP:0007502)2.31410426
30Pulmonary artery stenosis (HP:0004415)2.30649078
31Hemiparesis (HP:0001269)2.30567327
32Alacrima (HP:0000522)2.30545602
33Absent septum pellucidum (HP:0001331)2.30293689
34True hermaphroditism (HP:0010459)2.29945778
35Large for gestational age (HP:0001520)2.26349727
36Synostosis involving the elbow (HP:0003938)2.25971388
37Humeroradial synostosis (HP:0003041)2.25971388
38Abnormality of incisor morphology (HP:0011063)2.24276524
39Coronal craniosynostosis (HP:0004440)2.23940797
40Hypoglycemic coma (HP:0001325)2.22472521
41Focal motor seizures (HP:0011153)2.18473946
42Hypoplasia of the iris (HP:0007676)2.17989235
43Sensory axonal neuropathy (HP:0003390)2.15422810
44Arterial tortuosity (HP:0005116)2.14522772
45Hyperinsulinemic hypoglycemia (HP:0000825)2.14314059
46Abnormality of the phalanges of the 2nd finger (HP:0009541)2.13276766
47Methylmalonic aciduria (HP:0012120)2.11852225
48Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.11337699
49Pancreatic cysts (HP:0001737)2.09410593
50Abnormality of the septum pellucidum (HP:0007375)2.09242310
51Nephronophthisis (HP:0000090)2.08703287
52Hyperglycinemia (HP:0002154)2.08628871
53Abnormality of the corticospinal tract (HP:0002492)2.08420785
54Postaxial hand polydactyly (HP:0001162)2.07889425
55Myelomeningocele (HP:0002475)2.07752494
56Abnormality of the middle phalanges of the toes (HP:0010183)2.06779315
57Abnormality of midbrain morphology (HP:0002418)2.04848766
58Molar tooth sign on MRI (HP:0002419)2.04848766
59Vaginal atresia (HP:0000148)2.04542315
60Hypoplastic left heart (HP:0004383)2.03852488
61Aplasia/Hypoplasia of the tongue (HP:0010295)2.03146075
62Parakeratosis (HP:0001036)2.03038084
63Medial flaring of the eyebrow (HP:0010747)2.02902476
64Polyphagia (HP:0002591)2.02817572
65Gait imbalance (HP:0002141)2.02224331
66Neonatal short-limb short stature (HP:0008921)2.00238280
67Mesomelia (HP:0003027)1.99801714
68Hypoglycemic seizures (HP:0002173)1.99307518
69Genital tract atresia (HP:0001827)1.96806445
70Corneal dystrophy (HP:0001131)1.96461626
71Renal hypoplasia (HP:0000089)1.96231575
72Bladder diverticulum (HP:0000015)1.95813101
73Infantile muscular hypotonia (HP:0008947)1.95043930
74Aplasia/Hypoplasia of the lens (HP:0008063)1.94566503
75Congenital primary aphakia (HP:0007707)1.94304784
76Shallow orbits (HP:0000586)1.91754331
77Abnormality of the labia minora (HP:0012880)1.89860366
78Sex reversal (HP:0012245)1.89145267
79Abnormal sex determination (HP:0012244)1.89145267
80Thickened helices (HP:0000391)1.88708308
81Abnormality of molar morphology (HP:0011070)1.86629495
82Abnormality of molar (HP:0011077)1.86629495
83Short tibia (HP:0005736)1.86427635
84Partial duplication of the phalanx of hand (HP:0009999)1.83750442
85Hyperventilation (HP:0002883)1.82877051
86Abnormal hair whorl (HP:0010721)1.82646393
87Postaxial foot polydactyly (HP:0001830)1.82282314
88Abnormality of the renal medulla (HP:0100957)1.82226830
89Decreased lacrimation (HP:0000633)1.81753290
90Aplasia/Hypoplasia of the tibia (HP:0005772)1.81359220
91Increased serum pyruvate (HP:0003542)1.81026113
92Abnormality of glycolysis (HP:0004366)1.81026113
93Bifid tongue (HP:0010297)1.80541800
94Epileptic encephalopathy (HP:0200134)1.79828579
95Ketoacidosis (HP:0001993)1.79712283
96Short foot (HP:0001773)1.79616248
97Nasolacrimal duct obstruction (HP:0000579)1.79350651
98Occipital encephalocele (HP:0002085)1.78809150
99Partial duplication of thumb phalanx (HP:0009944)1.77471893
100Hypoplastic heart (HP:0001961)1.76482342
101Premature skin wrinkling (HP:0100678)1.75857355
102Abnormality of the fetal cardiovascular system (HP:0010948)1.75763255
103Abnormal umbilical cord blood vessels (HP:0011403)1.75763255
104Single umbilical artery (HP:0001195)1.75763255
105Mixed hearing impairment (HP:0000410)1.75197239
106Onion bulb formation (HP:0003383)1.74952880
107Spinal rigidity (HP:0003306)1.74128329
108Blue irides (HP:0000635)1.73872224
109Hypothermia (HP:0002045)1.73384737
110Nephrogenic diabetes insipidus (HP:0009806)1.72464395
111Progressive macrocephaly (HP:0004481)1.71830963
112Abnormality of the nasolacrimal system (HP:0000614)1.71814104
113Amblyopia (HP:0000646)1.70111062
114Chorioretinal atrophy (HP:0000533)1.68330760
115Congenital sensorineural hearing impairment (HP:0008527)1.67913305
116Cupped ear (HP:0000378)1.67366853
117Long nose (HP:0003189)1.67298686
118Median cleft lip (HP:0000161)1.67031131
119Limb dystonia (HP:0002451)1.66989695
120Enlarged penis (HP:0000040)1.66918634
121Duplicated collecting system (HP:0000081)1.66495211
122Short hallux (HP:0010109)1.66255547
123Atonic seizures (HP:0010819)1.65854446
124Hypoplastic pelvis (HP:0008839)1.64771637
125Broad foot (HP:0001769)1.64582707
126Conical tooth (HP:0000698)1.63893986
127Hyperglycemia (HP:0003074)1.63352884
128EEG with generalized epileptiform discharges (HP:0011198)1.62480480
129Drooling (HP:0002307)1.62380368
130Abnormality of vitamin B metabolism (HP:0004340)1.61711142
131Cystic liver disease (HP:0006706)1.61610175
132Severe Myopia (HP:0011003)1.61584755
133Abnormality of the metopic suture (HP:0005556)1.60775043
134Microglossia (HP:0000171)1.60604189
135Anteriorly placed anus (HP:0001545)1.60113678
136Intellectual disability, moderate (HP:0002342)1.59823485
137Steppage gait (HP:0003376)1.59232517
138Epileptiform EEG discharges (HP:0011182)1.59219424
139Pheochromocytoma (HP:0002666)1.58585296
140Metaphyseal dysplasia (HP:0100255)1.56989236
141Morphological abnormality of the middle ear (HP:0008609)1.56410481
142Aplasia of the musculature (HP:0100854)1.56377891
143Flared iliac wings (HP:0002869)1.56282891
144Hypsarrhythmia (HP:0002521)1.56270513
145Abnormality of the lacrimal duct (HP:0011481)1.55739146
146Leukodystrophy (HP:0002415)1.55645477
147Methylmalonic acidemia (HP:0002912)1.54652880
148Overgrowth (HP:0001548)1.54127786
149Arthropathy (HP:0003040)1.53821344
150Optic nerve hypoplasia (HP:0000609)1.52671302
151Chronic hepatic failure (HP:0100626)1.52224389
152Ankle contracture (HP:0006466)1.52048293
153Poor suck (HP:0002033)1.51524875
154Aortic aneurysm (HP:0004942)1.51160125
155Progressive inability to walk (HP:0002505)1.51068348
156Prominent supraorbital ridges (HP:0000336)1.50664774
157Gastrointestinal atresia (HP:0002589)1.49725804
158Limited hip movement (HP:0008800)1.49689476
159Narrow forehead (HP:0000341)1.49016099
160Lymphangioma (HP:0100764)1.48663585
161Aplasia/hypoplasia of the uterus (HP:0008684)1.48365801
162Decreased testicular size (HP:0008734)1.47745777
163Aqueductal stenosis (HP:0002410)1.46682944
164Disproportionate short-trunk short stature (HP:0003521)1.46387299
165Aplasia/Hypoplasia of the hallux (HP:0008362)1.44419948
166Specific learning disability (HP:0001328)1.43918301
167Sclerocornea (HP:0000647)1.42893876
168Abnormality of the renal cortex (HP:0011035)1.42683971
169Cardiovascular calcification (HP:0011915)1.41894207
170Poor coordination (HP:0002370)1.39501268
171Mitral stenosis (HP:0001718)1.38952030
172Abnormality of the ischium (HP:0003174)1.38949276
173Inability to walk (HP:0002540)1.38864739
174Bowel diverticulosis (HP:0005222)1.38575519
175Preaxial foot polydactyly (HP:0001841)1.38574909
176Male pseudohermaphroditism (HP:0000037)1.37616607
177Astrocytoma (HP:0009592)1.37344192
178Abnormality of the astrocytes (HP:0100707)1.37344192

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.82955058
2CASK3.95608368
3STK393.28831749
4PRPF4B3.23665424
5TRIM282.90922173
6BCR2.61800711
7TNIK2.61232545
8OXSR12.37031041
9MAP4K22.13533554
10TIE12.13464535
11MAPK152.03167972
12MAP3K41.95004985
13NEK61.86201133
14PKN11.82432962
15FGFR21.73702516
16BMPR1B1.71326720
17MAPK131.63282050
18MYLK1.60836339
19PINK11.55989398
20EPHB11.53764333
21WNK41.48557666
22LIMK11.47522513
23MUSK1.46379694
24SGK4941.41753375
25SGK2231.41753375
26NTRK11.41642625
27PBK1.40626075
28MAPKAPK51.39760773
29EPHB21.38822896
30ZAK1.37058016
31MET1.35503131
32TGFBR21.34254911
33PLK21.30010267
34MAP2K71.29535779
35WNK11.28035931
36UHMK11.27498247
37DDR21.25344064
38EPHA41.24784269
39NTRK21.24719044
40PLK31.23416959
41WNK31.23383279
42DYRK21.21918738
43MKNK11.17196181
44PRKCE1.16363483
45ERBB31.16199164
46INSRR1.14974367
47ROCK21.13458098
48OBSCN1.11741401
49PNCK1.11720947
50CAMK2D1.08686143
51CAMK2B1.07785240
52STK161.07609081
53GRK71.07204173
54CSNK1A1L1.06921678
55CSNK1G31.05037846
56PIK3CA1.04697980
57MST41.01359890
58MARK11.01281381
59PIK3CG0.99379152
60EIF2AK30.98050603
61STK38L0.96357317
62PTK2B0.95782062
63PAK30.95704195
64CDK190.94824174
65CAMK2A0.94636686
66NEK10.93760128
67FER0.93586655
68YES10.93269397
69ACVR1B0.91884629
70BMPR20.90393709
71TESK10.88950735
72ERBB40.87917774
73FGR0.86593630
74LMTK20.85671191
75PHKG10.84848581
76PHKG20.84848581
77AKT30.83409630
78PRKD30.82546992
79ADRBK20.80596957
80STK30.80001518
81CSNK1G10.77352561
82PTK20.77212138
83CAMK1G0.76775183
84MKNK20.75336111
85CDK30.73993165
86TAF10.72519100
87CAMK2G0.71193530
88PRKCH0.69957657
89CSNK1G20.69753983
90SIK30.67638272
91CLK10.67278705
92ROCK10.67015402
93CAMK1D0.65525515
94NTRK30.63907874
95LATS10.63663848
96MAP3K120.62210548
97MAPK70.61500133
98GRK10.59606856
99TRPM70.59380686
100PRKG10.58598390
101WEE10.58458721
102NEK90.54531371
103CDK50.54243648
104CSNK1A10.53874942
105EPHA30.53559041
106SGK20.53255265
107ICK0.53001312
108PLK10.52086057
109NME10.52038711
110PRKD20.51585920
111ADRBK10.51344473
112BCKDK0.50615875
113PAK60.50210098
114IRAK20.48959897
115ARAF0.47783078
116MARK20.47455388
117PRKD10.47436570
118FGFR10.47321326
119IRAK10.46562502
120TYRO30.46392656
121CDK140.45355400
122NUAK10.45179774
123CAMK10.44405930
124PRKCG0.43025702
125PDGFRA0.42858756
126MINK10.42281707
127TGFBR10.41357423
128KSR10.41066422
129PRKACA0.40788571
130DMPK0.40583098
131PDK20.40133368
132VRK10.40116107
133ILK0.38530488
134DYRK30.36825332
135BUB10.36573178
136MAPKAPK30.35993423
137BRSK20.35732977

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.30457295
2Fatty acid elongation_Homo sapiens_hsa000623.00107521
3Steroid biosynthesis_Homo sapiens_hsa001002.90888248
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.33184056
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.30183680
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.25025336
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.17278303
8Ether lipid metabolism_Homo sapiens_hsa005652.14261005
9Axon guidance_Homo sapiens_hsa043602.05232563
10Oxidative phosphorylation_Homo sapiens_hsa001901.94769697
11Butanoate metabolism_Homo sapiens_hsa006501.91455589
12Nicotine addiction_Homo sapiens_hsa050331.87576462
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83599874
14Propanoate metabolism_Homo sapiens_hsa006401.76242657
15ECM-receptor interaction_Homo sapiens_hsa045121.74370241
16Morphine addiction_Homo sapiens_hsa050321.68827863
17Protein export_Homo sapiens_hsa030601.66524267
18GABAergic synapse_Homo sapiens_hsa047271.62732326
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.59636754
20Serotonergic synapse_Homo sapiens_hsa047261.59633689
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54919876
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51934697
23Circadian entrainment_Homo sapiens_hsa047131.51232991
24Parkinsons disease_Homo sapiens_hsa050121.49575596
25Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.48724914
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.48589272
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.39806444
28Hedgehog signaling pathway_Homo sapiens_hsa043401.37647164
29Glutamatergic synapse_Homo sapiens_hsa047241.36857177
30Vitamin B6 metabolism_Homo sapiens_hsa007501.35011653
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.30868520
32Alzheimers disease_Homo sapiens_hsa050101.30516834
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.30277139
34Sphingolipid metabolism_Homo sapiens_hsa006001.30070909
35Selenocompound metabolism_Homo sapiens_hsa004501.29659227
36Arachidonic acid metabolism_Homo sapiens_hsa005901.28329834
37Dilated cardiomyopathy_Homo sapiens_hsa054141.28128940
38Ovarian steroidogenesis_Homo sapiens_hsa049131.23847023
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.23453031
40Vibrio cholerae infection_Homo sapiens_hsa051101.22563192
41Basal cell carcinoma_Homo sapiens_hsa052171.21207857
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.21196875
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.20823047
44Vascular smooth muscle contraction_Homo sapiens_hsa042701.18738511
45Long-term depression_Homo sapiens_hsa047301.18690020
46Folate biosynthesis_Homo sapiens_hsa007901.16431981
47Rheumatoid arthritis_Homo sapiens_hsa053231.15326595
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.15231466
49Peroxisome_Homo sapiens_hsa041461.14668537
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14495019
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09719916
52Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.09608487
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09059163
54Taste transduction_Homo sapiens_hsa047421.08299469
55Cardiac muscle contraction_Homo sapiens_hsa042601.07669447
56Renin secretion_Homo sapiens_hsa049241.06093654
57Collecting duct acid secretion_Homo sapiens_hsa049661.05959639
58Tryptophan metabolism_Homo sapiens_hsa003801.04893974
59Fatty acid metabolism_Homo sapiens_hsa012121.02692335
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01917664
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01702081
62beta-Alanine metabolism_Homo sapiens_hsa004100.98217519
63Pyruvate metabolism_Homo sapiens_hsa006200.95126319
64Phagosome_Homo sapiens_hsa041450.94651933
65Focal adhesion_Homo sapiens_hsa045100.94577169
66Protein digestion and absorption_Homo sapiens_hsa049740.94298601
67Melanogenesis_Homo sapiens_hsa049160.94168481
68Autoimmune thyroid disease_Homo sapiens_hsa053200.94140498
69Fatty acid degradation_Homo sapiens_hsa000710.93630720
70Huntingtons disease_Homo sapiens_hsa050160.91859160
71Gap junction_Homo sapiens_hsa045400.91296822
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90819457
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89843183
74Glutathione metabolism_Homo sapiens_hsa004800.89255661
75Basal transcription factors_Homo sapiens_hsa030220.89090363
76Ras signaling pathway_Homo sapiens_hsa040140.89082078
77Cocaine addiction_Homo sapiens_hsa050300.89003672
78Hippo signaling pathway_Homo sapiens_hsa043900.88879961
79Calcium signaling pathway_Homo sapiens_hsa040200.88747264
80N-Glycan biosynthesis_Homo sapiens_hsa005100.88351208
81Salivary secretion_Homo sapiens_hsa049700.87317653
82Wnt signaling pathway_Homo sapiens_hsa043100.87121979
83Tight junction_Homo sapiens_hsa045300.86437162
84Olfactory transduction_Homo sapiens_hsa047400.86305680
85PI3K-Akt signaling pathway_Homo sapiens_hsa041510.86156397
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86142995
87Synaptic vesicle cycle_Homo sapiens_hsa047210.85990453
88Cholinergic synapse_Homo sapiens_hsa047250.85161445
89Malaria_Homo sapiens_hsa051440.83504204
90Dopaminergic synapse_Homo sapiens_hsa047280.82446521
91Circadian rhythm_Homo sapiens_hsa047100.79666300
92cAMP signaling pathway_Homo sapiens_hsa040240.78907906
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78770112
94Retinol metabolism_Homo sapiens_hsa008300.78630856
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78078197
96Phototransduction_Homo sapiens_hsa047440.75608145
97TGF-beta signaling pathway_Homo sapiens_hsa043500.75538876
98Insulin secretion_Homo sapiens_hsa049110.75460754
99Linoleic acid metabolism_Homo sapiens_hsa005910.72553882
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72169564
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71012190
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68927639
103Sulfur metabolism_Homo sapiens_hsa009200.68348418
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68278926
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68119588
106Glycosaminoglycan degradation_Homo sapiens_hsa005310.66179512
107Proteasome_Homo sapiens_hsa030500.65854734
108Lysine degradation_Homo sapiens_hsa003100.64369263
109Amphetamine addiction_Homo sapiens_hsa050310.63943666
110Renal cell carcinoma_Homo sapiens_hsa052110.63889609
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.63656654
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63429537
113Arginine and proline metabolism_Homo sapiens_hsa003300.63299777
114Regulation of autophagy_Homo sapiens_hsa041400.62975886
115Oxytocin signaling pathway_Homo sapiens_hsa049210.62864892
116Metabolic pathways_Homo sapiens_hsa011000.62639993
117Thyroid hormone synthesis_Homo sapiens_hsa049180.62059802
118Rap1 signaling pathway_Homo sapiens_hsa040150.61034938
119Melanoma_Homo sapiens_hsa052180.60911854
120Chemical carcinogenesis_Homo sapiens_hsa052040.60771709
1212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60627066
122Lysosome_Homo sapiens_hsa041420.59969011
123Complement and coagulation cascades_Homo sapiens_hsa046100.58344312
124Non-homologous end-joining_Homo sapiens_hsa034500.57896311
125Nitrogen metabolism_Homo sapiens_hsa009100.57144666
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.56911175
127Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56760258
128Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55398598
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54557625
130Prion diseases_Homo sapiens_hsa050200.54098911
131ErbB signaling pathway_Homo sapiens_hsa040120.53235111
132ABC transporters_Homo sapiens_hsa020100.52749418
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52717378
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52506485
135Fanconi anemia pathway_Homo sapiens_hsa034600.51994338
136Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51375933
137Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49634792
138Gastric acid secretion_Homo sapiens_hsa049710.49124694
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48170947
140Oocyte meiosis_Homo sapiens_hsa041140.46076275
141RNA polymerase_Homo sapiens_hsa030200.45106763
142Pathways in cancer_Homo sapiens_hsa052000.43957860
143Sphingolipid signaling pathway_Homo sapiens_hsa040710.43066381
144Proteoglycans in cancer_Homo sapiens_hsa052050.40068666
145Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39273458
146Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37627154
147Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37357366
148Vitamin digestion and absorption_Homo sapiens_hsa049770.36206329
149Prostate cancer_Homo sapiens_hsa052150.35023657
150Endocytosis_Homo sapiens_hsa041440.34214988

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