SGCZ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The zeta-sarcoglycan gene measures over 465 kb and localizes to 8p22. This protein is part of the sarcoglycan complex, a group of 6 proteins. The sarcoglycans are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a carboxyl-terminal cluster with several conserved cysteine residues. The sarcoglycan complex is part of the dystrophin-associated glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extra-cellular matrix. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1RNA destabilization (GO:0050779)7.04033729
2regulation of acrosome reaction (GO:0060046)6.45998321
3intestinal cholesterol absorption (GO:0030299)6.38086983
4auditory behavior (GO:0031223)6.30837941
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.35921281
6piRNA metabolic process (GO:0034587)5.27695438
7mechanosensory behavior (GO:0007638)5.27002453
8neuron cell-cell adhesion (GO:0007158)5.23167803
9startle response (GO:0001964)5.20489244
10presynaptic membrane assembly (GO:0097105)4.99309272
11response to auditory stimulus (GO:0010996)4.94552938
12regulation of DNA methylation (GO:0044030)4.89339401
13regulation of synaptic vesicle exocytosis (GO:2000300)4.84346051
14vocalization behavior (GO:0071625)4.83479936
15innervation (GO:0060384)4.82798041
16synaptic vesicle exocytosis (GO:0016079)4.70461113
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.51955224
18presynaptic membrane organization (GO:0097090)4.38035414
19neuron fate determination (GO:0048664)4.30590887
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.28308795
21glutamate secretion (GO:0014047)4.27461077
22DNA methylation involved in gamete generation (GO:0043046)4.23588033
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.22361005
24synaptic vesicle docking involved in exocytosis (GO:0016081)4.22115896
25regulation of synaptic vesicle transport (GO:1902803)4.16090702
26cochlea development (GO:0090102)4.15595549
27negative regulation of synaptic transmission, GABAergic (GO:0032229)4.14416160
28protein localization to synapse (GO:0035418)4.14200986
29neuronal action potential propagation (GO:0019227)4.13546515
30neurotransmitter secretion (GO:0007269)4.05919847
31regulation of glutamate receptor signaling pathway (GO:1900449)4.00429957
32postsynaptic membrane organization (GO:0001941)3.98787561
33regulation of action potential (GO:0098900)3.98164875
34neurotransmitter-gated ion channel clustering (GO:0072578)3.97137333
35relaxation of smooth muscle (GO:0044557)3.93717329
36catecholamine biosynthetic process (GO:0042423)3.88697640
37catechol-containing compound biosynthetic process (GO:0009713)3.88697640
38retinal cone cell development (GO:0046549)3.85836017
39neuron-neuron synaptic transmission (GO:0007270)3.83691131
40multicellular organism reproduction (GO:0032504)3.80825006
41regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.78378929
42serotonin metabolic process (GO:0042428)3.78147380
43synapse assembly (GO:0007416)3.75998911
44synaptic transmission, glutamatergic (GO:0035249)3.72589034
45positive regulation of histone H3-K4 methylation (GO:0051571)3.69979318
46primary amino compound metabolic process (GO:1901160)3.69518705
47positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.67242858
48brain morphogenesis (GO:0048854)3.66945327
49glycerophospholipid catabolic process (GO:0046475)3.66030045
50negative regulation of dendrite morphogenesis (GO:0050774)3.65678077
51somite rostral/caudal axis specification (GO:0032525)3.63376444
52regulation of meiosis I (GO:0060631)3.63307931
53regulation of female gonad development (GO:2000194)3.63220336
54striatum development (GO:0021756)3.58022018
55locomotory exploration behavior (GO:0035641)3.56988290
56fusion of sperm to egg plasma membrane (GO:0007342)3.56894100
57epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.55491705
58behavioral response to ethanol (GO:0048149)3.54413481
59synaptic vesicle maturation (GO:0016188)3.53657211
60negative regulation of digestive system process (GO:0060457)3.53058992
61gamma-aminobutyric acid signaling pathway (GO:0007214)3.52634729
62long-term synaptic potentiation (GO:0060291)3.52488027
63regulation of calcium ion-dependent exocytosis (GO:0017158)3.51846350
64glutamate receptor signaling pathway (GO:0007215)3.49745748
65positive regulation of synapse maturation (GO:0090129)3.48401269
66negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.47647979
67dopamine biosynthetic process (GO:0042416)3.46173825
68neuron recognition (GO:0008038)3.44969888
69ionotropic glutamate receptor signaling pathway (GO:0035235)3.44591571
70negative regulation of dendrite development (GO:2000171)3.41223659
71synaptic vesicle endocytosis (GO:0048488)3.39271978
72aggressive behavior (GO:0002118)3.38051083
73regulation of glutamate secretion (GO:0014048)3.36946707
74neurotransmitter transport (GO:0006836)3.36308680
75meiotic cell cycle (GO:0051321)3.35970103
76G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.33523075
77detection of calcium ion (GO:0005513)3.33474389
78transmission of nerve impulse (GO:0019226)3.31588082
79interkinetic nuclear migration (GO:0022027)3.31283579
80regulation of synaptic transmission, glutamatergic (GO:0051966)3.30430442
81positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.29786457
82plasma membrane fusion (GO:0045026)3.28871638
83positive regulation of action potential (GO:0045760)3.28216499
84regulation of synapse structural plasticity (GO:0051823)3.23638320
85regulation of neuronal synaptic plasticity (GO:0048168)3.20378793
86urinary tract smooth muscle contraction (GO:0014848)3.19958611
87regulation of vesicle fusion (GO:0031338)3.19279705
88protein polyglutamylation (GO:0018095)3.18408577
89synapse organization (GO:0050808)3.17303935
90response to histamine (GO:0034776)3.14483886
91membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.14374404
92regulation of neurotransmitter secretion (GO:0046928)3.14240938
93negative regulation of mast cell activation (GO:0033004)3.13955801
94regulation of long-term neuronal synaptic plasticity (GO:0048169)3.13154274
95serotonin receptor signaling pathway (GO:0007210)3.11798128
96negative regulation of neurotransmitter transport (GO:0051589)3.09422527
97axonal fasciculation (GO:0007413)3.09226694
98regulation of excitatory postsynaptic membrane potential (GO:0060079)3.08283189
99membrane hyperpolarization (GO:0060081)3.07841208
100reflex (GO:0060004)3.07798897
101regulation of synapse maturation (GO:0090128)3.07616510
102behavioral response to cocaine (GO:0048148)3.07607752
103positive regulation of membrane potential (GO:0045838)3.07115881
104membrane depolarization during action potential (GO:0086010)3.05722395
105preassembly of GPI anchor in ER membrane (GO:0016254)3.05076705
106exploration behavior (GO:0035640)3.05022487
107regulation of postsynaptic membrane potential (GO:0060078)3.04486212
108tyrosine phosphorylation of STAT protein (GO:0007260)3.04470056
109positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.04414718
110positive regulation of neurotransmitter secretion (GO:0001956)3.03724037
111regulation of steroid hormone secretion (GO:2000831)2.99068163
112cerebellar granule cell differentiation (GO:0021707)2.98943175
113positive regulation of synaptic transmission, GABAergic (GO:0032230)2.98613807
114regulation of neurotransmitter levels (GO:0001505)2.98602893
115phosphorelay signal transduction system (GO:0000160)2.98323255
116female gamete generation (GO:0007292)2.97698288
117regulation of neurotransmitter transport (GO:0051588)2.97644037
118negative regulation of amino acid transport (GO:0051956)2.96431643
119synaptic vesicle transport (GO:0048489)2.93166965
120establishment of synaptic vesicle localization (GO:0097480)2.93166965
121epithelial cilium movement (GO:0003351)2.91205558
122positive regulation of neurotransmitter transport (GO:0051590)2.90789980
123regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.90049083
124L-phenylalanine catabolic process (GO:0006559)2.89884061
125erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.89884061
126behavioral response to nicotine (GO:0035095)2.89825775
127cell migration in hindbrain (GO:0021535)2.89181289
128cerebellar Purkinje cell differentiation (GO:0021702)2.89059025
129transferrin transport (GO:0033572)2.88704942
130erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.87961985
131L-phenylalanine metabolic process (GO:0006558)2.87961985
132membrane depolarization (GO:0051899)2.86948218
133energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.86632177
134ATP hydrolysis coupled proton transport (GO:0015991)2.86632177
135positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.86593507
136regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.84888181
137regulation of synaptic plasticity (GO:0048167)2.82125173
138prepulse inhibition (GO:0060134)2.81768129
139synaptic transmission (GO:0007268)2.80828364
140calcium ion-dependent exocytosis (GO:0017156)2.80323495
141regulation of cilium movement (GO:0003352)2.79789518
142inner ear receptor cell development (GO:0060119)2.78527959
143positive regulation of synapse assembly (GO:0051965)2.77905540
144gamma-aminobutyric acid transport (GO:0015812)2.76571690
145retinal ganglion cell axon guidance (GO:0031290)2.76232091
146cell morphogenesis involved in neuron differentiation (GO:0048667)2.75009304
147immunoglobulin mediated immune response (GO:0016064)2.74896964
148regulation of synaptic transmission, GABAergic (GO:0032228)2.74580281
149male meiosis (GO:0007140)2.74512761
150regulation of voltage-gated calcium channel activity (GO:1901385)2.73852289
151proline transport (GO:0015824)2.73154047
152negative regulation of cytosolic calcium ion concentration (GO:0051481)2.69040113
153axon ensheathment in central nervous system (GO:0032291)2.67959598
154central nervous system myelination (GO:0022010)2.67959598
155regulation of corticosteroid hormone secretion (GO:2000846)2.65553791
156reproduction (GO:0000003)2.64172772
157pyrimidine nucleobase catabolic process (GO:0006208)2.64154992
158detection of light stimulus involved in visual perception (GO:0050908)2.62939642
159detection of light stimulus involved in sensory perception (GO:0050962)2.62939642
160neuronal action potential (GO:0019228)2.61447214
161negative regulation of meiosis (GO:0045835)2.61037613
162regulation of microtubule-based movement (GO:0060632)2.60482055
163positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.59338348
164regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.59338348
165male meiosis I (GO:0007141)2.58620356
166regulation of histone H3-K4 methylation (GO:0051569)2.58313456
167ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.57388917
168behavioral response to pain (GO:0048266)2.55381129
169DNA methylation (GO:0006306)2.53670686
170DNA alkylation (GO:0006305)2.53670686
171viral protein processing (GO:0019082)2.51046886
172nonmotile primary cilium assembly (GO:0035058)2.50525915
173gene silencing by RNA (GO:0031047)2.47800493
174indole-containing compound metabolic process (GO:0042430)2.43949341
175photoreceptor cell maintenance (GO:0045494)2.43380905
176oogenesis (GO:0048477)2.40832585

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.32040309
2GBX2_23144817_ChIP-Seq_PC3_Human4.53581617
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.47560340
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.37393457
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.93595896
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.83935900
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.78833166
8* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77044947
9* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58741127
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.57687329
11TAF15_26573619_Chip-Seq_HEK293_Human2.56239289
12REST_21632747_ChIP-Seq_MESCs_Mouse2.49436781
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44210759
14* EZH2_27304074_Chip-Seq_ESCs_Mouse2.44013072
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.37864644
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.34095390
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.31162724
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.28492274
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.27427960
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.27427960
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27319923
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.25925448
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.20979655
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.16658869
25* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.14504066
26BMI1_23680149_ChIP-Seq_NPCS_Mouse2.12687230
27* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.10798662
28VDR_22108803_ChIP-Seq_LS180_Human2.08405709
29* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.07425830
30* RNF2_27304074_Chip-Seq_ESCs_Mouse1.93938231
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.91156630
32P300_19829295_ChIP-Seq_ESCs_Human1.91036854
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.88475113
34* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87180948
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83634090
36* SMAD4_21799915_ChIP-Seq_A2780_Human1.83446888
37* REST_18959480_ChIP-ChIP_MESCs_Mouse1.82631085
38* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81854089
39AR_21572438_ChIP-Seq_LNCaP_Human1.76829402
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.72534164
41DROSHA_22980978_ChIP-Seq_HELA_Human1.70904933
42FUS_26573619_Chip-Seq_HEK293_Human1.70461980
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68089931
44* RNF2_27304074_Chip-Seq_NSC_Mouse1.64059667
45IGF1R_20145208_ChIP-Seq_DFB_Human1.63310971
46RARB_27405468_Chip-Seq_BRAIN_Mouse1.62304434
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.61122299
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.59372225
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.50888232
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49646785
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.49367715
52* STAT3_23295773_ChIP-Seq_U87_Human1.46982815
53* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45537263
54* CBP_20019798_ChIP-Seq_JUKART_Human1.45537263
55* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43021936
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42869726
57* SOX2_21211035_ChIP-Seq_LN229_Gbm1.40494489
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40176558
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38676046
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38255819
61AR_25329375_ChIP-Seq_VCAP_Human1.31729775
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31633595
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27691185
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27230979
65TP53_22573176_ChIP-Seq_HFKS_Human1.26867676
66EWS_26573619_Chip-Seq_HEK293_Human1.26361976
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.24012522
68* TCF4_23295773_ChIP-Seq_U87_Human1.23002415
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22464782
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.22422930
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.22295254
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22249279
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21350660
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20445474
75ZNF274_21170338_ChIP-Seq_K562_Hela1.19925511
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17637222
77JUN_21703547_ChIP-Seq_K562_Human1.17586977
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17157386
79ER_23166858_ChIP-Seq_MCF-7_Human1.16953537
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16453707
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15722688
82RUNX2_22187159_ChIP-Seq_PCA_Human1.15220312
83PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14986658
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.14980499
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14971184
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14760444
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12790972
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10648621
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10532822
90ERG_21242973_ChIP-ChIP_JURKAT_Human1.10038991
91* AR_19668381_ChIP-Seq_PC3_Human1.07917633
92E2F1_18555785_Chip-Seq_ESCs_Mouse1.07056724
93VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05446873
94AHR_22903824_ChIP-Seq_MCF-7_Human1.05432724
95TCF4_22108803_ChIP-Seq_LS180_Human1.05020410
96FOXA1_25329375_ChIP-Seq_VCAP_Human1.04016194
97FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04016194
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03824538
99FLI1_21867929_ChIP-Seq_TH2_Mouse1.03194831
100SOX9_26525672_Chip-Seq_HEART_Mouse1.02474133
101CMYC_18555785_Chip-Seq_ESCs_Mouse1.02054273
102P53_22387025_ChIP-Seq_ESCs_Mouse1.01865102
103EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01748835
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01297813
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01297813
106KDM2B_26808549_Chip-Seq_REH_Human1.01097882
107PRDM14_20953172_ChIP-Seq_ESCs_Human1.00728162
108BCAT_22108803_ChIP-Seq_LS180_Human1.00281276
109EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00109285
110RING1B_27294783_Chip-Seq_ESCs_Mouse0.99498261
111P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99319491
112HTT_18923047_ChIP-ChIP_STHdh_Human0.99094838
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98715120
114LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97987190
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97928635
116AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97862360
117RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97726841
118EZH2_27294783_Chip-Seq_NPCs_Mouse0.97490042
119NANOG_19829295_ChIP-Seq_ESCs_Human0.96816670
120SOX2_19829295_ChIP-Seq_ESCs_Human0.96816670
121* TAL1_26923725_Chip-Seq_HPCs_Mouse0.95309267
122TP53_18474530_ChIP-ChIP_U2OS_Human0.95130362
123SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94939180
124CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94483988
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93292512
126CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93111092
127STAT3_18555785_Chip-Seq_ESCs_Mouse0.93089603
128NOTCH1_21737748_ChIP-Seq_TLL_Human0.91760570

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.19352955
2MP0003880_abnormal_central_pattern4.66886905
3MP0004859_abnormal_synaptic_plasticity4.34120692
4MP0001968_abnormal_touch/_nociception3.70548380
5MP0003635_abnormal_synaptic_transmissio3.43639313
6MP0002736_abnormal_nociception_after3.42860969
7MP0008877_abnormal_DNA_methylation3.18140385
8MP0005423_abnormal_somatic_nervous3.09682392
9MP0009745_abnormal_behavioral_response2.98336082
10MP0004270_analgesia2.92839848
11MP0003718_maternal_effect2.91511000
12MP0002063_abnormal_learning/memory/cond2.84694990
13MP0009046_muscle_twitch2.81791038
14MP0002064_seizures2.78757981
15MP0002572_abnormal_emotion/affect_behav2.65292639
16MP0002734_abnormal_mechanical_nocicepti2.48604939
17MP0002735_abnormal_chemical_nociception2.46618357
18MP0002272_abnormal_nervous_system2.40108612
19MP0006276_abnormal_autonomic_nervous2.28380771
20MP0001486_abnormal_startle_reflex2.27672238
21MP0001986_abnormal_taste_sensitivity2.25952122
22MP0001501_abnormal_sleep_pattern2.23672168
23MP0005084_abnormal_gallbladder_morpholo2.21431593
24MP0003122_maternal_imprinting2.18449483
25MP0002067_abnormal_sensory_capabilities2.16595082
26MP0002733_abnormal_thermal_nociception2.16568418
27MP0002822_catalepsy2.14261043
28MP0005646_abnormal_pituitary_gland2.13722871
29MP0002184_abnormal_innervation2.02421203
30MP0001529_abnormal_vocalization2.01878018
31MP0001970_abnormal_pain_threshold1.93376292
32MP0001188_hyperpigmentation1.90322537
33MP0000778_abnormal_nervous_system1.87182916
34MP0001984_abnormal_olfaction1.83301430
35MP0001502_abnormal_circadian_rhythm1.75368380
36MP0010386_abnormal_urinary_bladder1.71961020
37MP0005085_abnormal_gallbladder_physiolo1.71957755
38MP0001440_abnormal_grooming_behavior1.68878282
39MP0002557_abnormal_social/conspecific_i1.65823471
40MP0003787_abnormal_imprinting1.65528576
41MP0001905_abnormal_dopamine_level1.63003606
42MP0002876_abnormal_thyroid_physiology1.61590186
43MP0009780_abnormal_chondrocyte_physiolo1.56088450
44MP0001666_abnormal_nutrient_absorption1.56007521
45MP0000955_abnormal_spinal_cord1.53738241
46MP0005386_behavior/neurological_phenoty1.53321723
47MP0004924_abnormal_behavior1.53321723
48MP0003879_abnormal_hair_cell1.51491429
49MP0005410_abnormal_fertilization1.45085038
50MP0003786_premature_aging1.44827726
51MP0008995_early_reproductive_senescence1.43371786
52MP0002837_dystrophic_cardiac_calcinosis1.39595602
53MP0004811_abnormal_neuron_physiology1.36468149
54MP0004142_abnormal_muscle_tone1.34595533
55MP0003121_genomic_imprinting1.33568432
56MP0005645_abnormal_hypothalamus_physiol1.31651618
57MP0008569_lethality_at_weaning1.28605673
58MP0002066_abnormal_motor_capabilities/c1.27936788
59MP0004885_abnormal_endolymph1.27105443
60MP0000631_abnormal_neuroendocrine_gland1.27012462
61MP0002138_abnormal_hepatobiliary_system1.26921415
62MP0002882_abnormal_neuron_morphology1.25769084
63MP0008058_abnormal_DNA_repair1.23536707
64MP0001929_abnormal_gametogenesis1.22734214
65MP0004742_abnormal_vestibular_system1.20056471
66MP0003329_amyloid_beta_deposits1.18145693
67MP0004043_abnormal_pH_regulation1.17067205
68MP0008875_abnormal_xenobiotic_pharmacok1.14974511
69MP0003698_abnormal_male_reproductive1.14793967
70MP0000230_abnormal_systemic_arterial1.11441125
71MP0005551_abnormal_eye_electrophysiolog1.10816831
72MP0002234_abnormal_pharynx_morphology1.07005953
73MP0000427_abnormal_hair_cycle1.04080984
74MP0009697_abnormal_copulation1.03516322
75MP0002909_abnormal_adrenal_gland1.02901653
76MP0008961_abnormal_basal_metabolism1.02226013
77MP0001963_abnormal_hearing_physiology1.02122602
78MP0005379_endocrine/exocrine_gland_phen1.00811299
79MP0004858_abnormal_nervous_system0.99802884
80MP0002069_abnormal_eating/drinking_beha0.99409293
81MP0003633_abnormal_nervous_system0.97479314
82MP0002210_abnormal_sex_determination0.94071285
83MP0005535_abnormal_body_temperature0.93407687
84MP0002152_abnormal_brain_morphology0.92615387
85MP0002752_abnormal_somatic_nervous0.92031573
86MP0006292_abnormal_olfactory_placode0.91346488
87MP0001664_abnormal_digestion0.90853881
88MP0005365_abnormal_bile_salt0.90764983
89MP0002638_abnormal_pupillary_reflex0.90154468
90MP0005257_abnormal_intraocular_pressure0.88929759
91MP0003252_abnormal_bile_duct0.88874154
92MP0003631_nervous_system_phenotype0.88756428
93MP0006035_abnormal_mitochondrial_morpho0.88733819
94MP0005389_reproductive_system_phenotype0.88670781
95MP0004782_abnormal_surfactant_physiolog0.87200872
96MP0008789_abnormal_olfactory_epithelium0.87189606
97MP0002102_abnormal_ear_morphology0.87070891
98MP0003195_calcinosis0.86949051
99MP0010329_abnormal_lipoprotein_level0.86452100
100MP0010234_abnormal_vibrissa_follicle0.84851281
101MP0000569_abnormal_digit_pigmentation0.84783176
102MP0005394_taste/olfaction_phenotype0.84065932
103MP0005499_abnormal_olfactory_system0.84065932
104MP0006072_abnormal_retinal_apoptosis0.83814752
105MP0002229_neurodegeneration0.83713634
106MP0002161_abnormal_fertility/fecundity0.83457773
107MP0001919_abnormal_reproductive_system0.83114972
108MP0000026_abnormal_inner_ear0.82805111
109MP0000653_abnormal_sex_gland0.81040040
110MP0005395_other_phenotype0.80321697
111MP0000751_myopathy0.79433440
112MP0002090_abnormal_vision0.79142407
113MP0001485_abnormal_pinna_reflex0.78430096
114MP0005253_abnormal_eye_physiology0.76752075
115MP0003632_abnormal_nervous_system0.76557320
116MP0009379_abnormal_foot_pigmentation0.76407369
117MP0003890_abnormal_embryonic-extraembry0.75294914
118MP0001177_atelectasis0.74522040
119MP0005248_abnormal_Harderian_gland0.74112850
120MP0002693_abnormal_pancreas_physiology0.73732084
121MP0004133_heterotaxia0.72920953
122MP0003136_yellow_coat_color0.72811734
123MP0004085_abnormal_heartbeat0.71791001
124MP0002160_abnormal_reproductive_system0.70339424
125MP0000013_abnormal_adipose_tissue0.68082085
126MP0002751_abnormal_autonomic_nervous0.67898753
127MP0004145_abnormal_muscle_electrophysio0.65693529
128MP0004215_abnormal_myocardial_fiber0.64649698
129MP0005171_absent_coat_pigmentation0.64481288
130MP0004484_altered_response_of0.63435715
131MP0003283_abnormal_digestive_organ0.62634995
132MP0005448_abnormal_energy_balance0.61790895
133MP0008874_decreased_physiological_sensi0.61345374
134MP0001346_abnormal_lacrimal_gland0.61258718
135MP0002078_abnormal_glucose_homeostasis0.60779981
136MP0008872_abnormal_physiological_respon0.60737323
137MP0003634_abnormal_glial_cell0.59744913
138MP0001943_abnormal_respiration0.59554911

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.00061918
2Focal seizures (HP:0007359)5.00212082
3Febrile seizures (HP:0002373)4.84610602
4Epileptic encephalopathy (HP:0200134)4.81197449
5Myokymia (HP:0002411)4.61909609
6Atonic seizures (HP:0010819)4.54389531
7Absence seizures (HP:0002121)4.26236606
8Sensory axonal neuropathy (HP:0003390)4.20387623
9Bile duct proliferation (HP:0001408)4.17748363
10Abnormal biliary tract physiology (HP:0012439)4.17748363
11Hyperventilation (HP:0002883)3.80959413
12Dialeptic seizures (HP:0011146)3.71036229
13Visual hallucinations (HP:0002367)3.67704711
14Type II lissencephaly (HP:0007260)3.62319722
15Nephronophthisis (HP:0000090)3.54214561
16Gait imbalance (HP:0002141)3.46664194
17Abnormality of aromatic amino acid family metabolism (HP:0004338)3.36328701
18Generalized tonic-clonic seizures (HP:0002069)3.29584446
19Congenital primary aphakia (HP:0007707)3.23018631
203-Methylglutaconic aciduria (HP:0003535)3.16166099
21Medial flaring of the eyebrow (HP:0010747)3.14338826
22Spastic gait (HP:0002064)3.13425445
23Renal Fanconi syndrome (HP:0001994)3.07432781
24Pheochromocytoma (HP:0002666)3.06096428
25Nephrogenic diabetes insipidus (HP:0009806)3.00782373
26Abnormality of the labia minora (HP:0012880)3.00464487
27Progressive cerebellar ataxia (HP:0002073)2.95196543
28Abnormality of the renal medulla (HP:0100957)2.92515055
29Pancreatic cysts (HP:0001737)2.89082759
30Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.85943424
31Epileptiform EEG discharges (HP:0011182)2.85719503
32Genital tract atresia (HP:0001827)2.77487494
33Generalized aminoaciduria (HP:0002909)2.73578878
34Protruding tongue (HP:0010808)2.73109519
35Poor coordination (HP:0002370)2.72055255
36EEG with generalized epileptiform discharges (HP:0011198)2.68515871
37Vaginal atresia (HP:0000148)2.68317430
38Supernumerary spleens (HP:0009799)2.66064394
39Severe Myopia (HP:0011003)2.63806076
40Abnormality of midbrain morphology (HP:0002418)2.62461491
41Molar tooth sign on MRI (HP:0002419)2.62461491
42Abnormal hair whorl (HP:0010721)2.61229238
43Hypothermia (HP:0002045)2.58321697
44Neuroendocrine neoplasm (HP:0100634)2.56616356
45Oligodactyly (hands) (HP:0001180)2.56565059
46Broad-based gait (HP:0002136)2.54683640
47Impaired vibration sensation in the lower limbs (HP:0002166)2.52853810
48Poor eye contact (HP:0000817)2.51685336
49Hypsarrhythmia (HP:0002521)2.48459272
50Gonadotropin excess (HP:0000837)2.47654730
51Cerebellar dysplasia (HP:0007033)2.47237744
52Specific learning disability (HP:0001328)2.46960667
53Abnormality of calcium-phosphate metabolism (HP:0100530)2.45956831
54Severe muscular hypotonia (HP:0006829)2.43349795
55Microvesicular hepatic steatosis (HP:0001414)2.42957487
56Urinary bladder sphincter dysfunction (HP:0002839)2.41680943
57Truncal ataxia (HP:0002078)2.39032114
58Lissencephaly (HP:0001339)2.39001815
59Drooling (HP:0002307)2.38676823
60Excessive salivation (HP:0003781)2.38676823
61Gaze-evoked nystagmus (HP:0000640)2.38086880
62Poor suck (HP:0002033)2.38073973
63Gastroesophageal reflux (HP:0002020)2.37815929
64Failure to thrive in infancy (HP:0001531)2.36740794
65Proximal tubulopathy (HP:0000114)2.34635236
66Increased hepatocellular lipid droplets (HP:0006565)2.33297012
67Volvulus (HP:0002580)2.33042757
68Chronic hepatic failure (HP:0100626)2.32857464
69Oligomenorrhea (HP:0000876)2.31085749
70Amblyopia (HP:0000646)2.30431086
71Abnormality of the renal cortex (HP:0011035)2.30127668
72Limb dystonia (HP:0002451)2.29838217
73Short tibia (HP:0005736)2.27461335
74Aplasia/Hypoplasia of the tibia (HP:0005772)2.25687562
75Akinesia (HP:0002304)2.22197164
76Abnormal social behavior (HP:0012433)2.21040698
77Impaired social interactions (HP:0000735)2.21040698
78Ankle clonus (HP:0011448)2.20935126
79Acute necrotizing encephalopathy (HP:0006965)2.19875341
80Generalized hypopigmentation of hair (HP:0011358)2.19658996
81Dysmetria (HP:0001310)2.19421289
82Optic nerve hypoplasia (HP:0000609)2.18287919
83Fair hair (HP:0002286)2.17610613
84Anxiety (HP:0000739)2.17489039
85Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.16250319
86Degeneration of the lateral corticospinal tracts (HP:0002314)2.16250319
87True hermaphroditism (HP:0010459)2.15841895
88Congenital hepatic fibrosis (HP:0002612)2.15674742
89Atelectasis (HP:0100750)2.15112715
90Polyphagia (HP:0002591)2.14475640
91Increased intramyocellular lipid droplets (HP:0012240)2.14265575
92Supranuclear gaze palsy (HP:0000605)2.13726117
93Anterior segment dysgenesis (HP:0007700)2.13421871
94Abnormality of the corticospinal tract (HP:0002492)2.12756343
95Pachygyria (HP:0001302)2.12038691
96Progressive macrocephaly (HP:0004481)2.11567495
97Central scotoma (HP:0000603)2.10977228
98Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.10317627
99Esotropia (HP:0000565)2.09120437
100Decreased central vision (HP:0007663)2.08947444
101Sensorimotor neuropathy (HP:0007141)2.07716697
102Genetic anticipation (HP:0003743)2.07532770
103Depression (HP:0000716)2.07124738
104Aplasia/Hypoplasia of the lens (HP:0008063)2.05506296
105Resting tremor (HP:0002322)2.04269591
106Dynein arm defect of respiratory motile cilia (HP:0012255)2.03691727
107Absent/shortened dynein arms (HP:0200106)2.03691727
108Absent speech (HP:0001344)2.02172831
109Abnormality of the pons (HP:0007361)2.01032799
110Hyperthyroidism (HP:0000836)2.01028601
111Methylmalonic aciduria (HP:0012120)1.99831998
112Status epilepticus (HP:0002133)1.99828213
113Azoospermia (HP:0000027)1.99496322
114Prolonged neonatal jaundice (HP:0006579)1.98704110
115Blue irides (HP:0000635)1.98529718
116Abnormal eating behavior (HP:0100738)1.97014979
117Torticollis (HP:0000473)1.96605326
118Methylmalonic acidemia (HP:0002912)1.95772750
119Urinary urgency (HP:0000012)1.94280837
120Abnormal mitochondria in muscle tissue (HP:0008316)1.94193595
121Spinal muscular atrophy (HP:0007269)1.94063565
122Narrow forehead (HP:0000341)1.92678395
123Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.92628534
124Osteomalacia (HP:0002749)1.92466136
125Overlapping toe (HP:0001845)1.92145385
126Abnormality of the fovea (HP:0000493)1.92073163
127Inability to walk (HP:0002540)1.91334718
128Large for gestational age (HP:0001520)1.90838244
129Hypoplasia of the fovea (HP:0007750)1.89591399
130Aplasia/Hypoplasia of the fovea (HP:0008060)1.89591399
131Progressive inability to walk (HP:0002505)1.88993243
132Pancreatic fibrosis (HP:0100732)1.88884539
133Limb hypertonia (HP:0002509)1.88222467
134Hypoplasia of the pons (HP:0012110)1.85597159
135Severe visual impairment (HP:0001141)1.85456524
136Lower limb muscle weakness (HP:0007340)1.85075458
137Ulnar claw (HP:0001178)1.84263859
138Gait ataxia (HP:0002066)1.82775383
139Insidious onset (HP:0003587)1.82709796
140Termporal pattern (HP:0011008)1.82709796
141Hemiparesis (HP:0001269)1.82686231
142Abnormal ciliary motility (HP:0012262)1.82663610
143Abnormality of glycolysis (HP:0004366)1.81784606
144Increased serum pyruvate (HP:0003542)1.81784606
145Aplasia/Hypoplasia of the tongue (HP:0010295)1.80664849
146Abnormal gallbladder morphology (HP:0012437)1.80410188
147Abnormality of salivation (HP:0100755)1.80312512
148Lipid accumulation in hepatocytes (HP:0006561)1.80089379
149Exotropia (HP:0000577)1.78053232
150Generalized myoclonic seizures (HP:0002123)1.77866147
151Mitochondrial inheritance (HP:0001427)1.77436066
152Abnormality of renal resorption (HP:0011038)1.77382841
153Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77284615
154Choreoathetosis (HP:0001266)1.76978898
155Abnormality of urine glucose concentration (HP:0011016)1.76299118
156Glycosuria (HP:0003076)1.76299118
157Aqueductal stenosis (HP:0002410)1.74041279
158Renal cortical cysts (HP:0000803)1.73853019
159Fetal akinesia sequence (HP:0001989)1.73803614
160Impaired smooth pursuit (HP:0007772)1.73660604
161Acute encephalopathy (HP:0006846)1.73593973
162Congenital stationary night blindness (HP:0007642)1.73285623
163Hyperaldosteronism (HP:0000859)1.72611036

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.43146610
2NTRK34.53206473
3PINK14.03992059
4EPHA43.66237213
5MAP2K72.92545608
6TNIK2.92120887
7GRK12.82666480
8TAOK32.67934861
9NTRK22.64475995
10MAP3K42.59020926
11MAP3K122.56883640
12DAPK22.56224718
13AKT32.26515130
14INSRR2.05374396
15MAPK131.94698683
16MAP2K41.81650943
17MAP3K91.80935044
18MARK11.80572502
19MINK11.73094131
20CCNB11.51514678
21DAPK11.44911538
22MAP4K21.43304494
23CDK191.40579904
24PLK21.36733054
25SIK31.36158413
26ERBB31.30926223
27GRK51.27899707
28RIPK41.27053017
29BMPR21.27007054
30PRPF4B1.26202963
31FER1.25916722
32SGK21.24961524
33OXSR11.24876732
34NEK11.23021717
35UHMK11.22605326
36BRSK21.22338799
37WEE11.22050645
38CDK51.20360218
39ZAK1.19850956
40SGK4941.19138152
41SGK2231.19138152
42EIF2AK31.16452553
43PAK61.12257743
44CAMK2A1.11303612
45TIE11.09224659
46NTRK11.07416375
47BRAF1.06932881
48TRIM281.05304717
49CAMKK21.04714550
50BCR0.99267558
51PRKCG0.98311231
52KSR10.97880492
53CAMKK10.97632023
54SIK20.95619883
55TLK10.93977654
56PASK0.90246450
57CSNK1G20.89567424
58CDC42BPA0.87723116
59TSSK60.86590754
60CHUK0.85024565
61CSNK1G30.84191953
62CAMK2B0.83594004
63MAP2K60.82472742
64STK38L0.80595590
65STK380.77604265
66PRKCE0.77339910
67BMPR1B0.76439377
68GRK70.76235631
69NEK60.75634969
70PRKCI0.75422759
71BCKDK0.71808113
72CSF1R0.70388565
73WNK40.70268176
74CDK180.69264742
75NME10.68011801
76PRKACB0.67113854
77ADRBK20.66765457
78IRAK10.66705434
79RPS6KA50.66567806
80ADRBK10.64274316
81MAP3K60.64094720
82RPS6KA20.63563873
83IRAK20.62903804
84STK160.62459641
85SGK30.61131735
86CDK150.60832175
87WNK10.60693817
88MARK20.60508676
89MAP3K20.60176870
90FGR0.59647942
91PRKCZ0.59519902
92PAK30.59081415
93TEC0.57642995
94STK110.57089455
95PNCK0.56248945
96FES0.56074651
97AURKA0.56000910
98PRKD30.55963318
99CAMK10.55052934
100CDK140.54669656
101SGK10.54355851
102PRKCH0.54084977
103ROCK20.53121436
104CDK30.52781432
105WNK30.51235923
106CAMK2G0.51210388
107CSNK1D0.50184770
108CAMK2D0.49786005
109PRKG10.49301665
110PIK3CA0.49136887
111CSNK1A1L0.48998833
112YES10.48734061
113KSR20.48220780
114CDK11A0.47736113
115CSNK1G10.47341698
116PRKACA0.46979032
117ITK0.46852891
118MET0.45835742
119PDK30.45824910
120PDK40.45824910
121MAPK30.43286487
122PRKCA0.42934430
123CDK90.42491399
124CSNK1A10.41458762
125DYRK1A0.41041719
126BRSK10.40983554
127CAMK40.39762501
128FRK0.39062523
129ARAF0.38958181
130PTK2B0.38883267
131TNK20.38564625
132CSNK1E0.36738375
133MAPK10.36587445
134MAP2K20.36250843
135MAPK100.35994044
136RPS6KB10.35983937
137VRK10.35792531
138STK240.35205564
139PHKG20.34962795
140PHKG10.34962795
141PRKCQ0.34635699
142FGFR20.34181760
143RPS6KA30.33365054

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.97143110
2Synaptic vesicle cycle_Homo sapiens_hsa047213.83268130
3Asthma_Homo sapiens_hsa053103.46067730
4Collecting duct acid secretion_Homo sapiens_hsa049662.80114297
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.77774933
6GABAergic synapse_Homo sapiens_hsa047272.73350402
7Circadian entrainment_Homo sapiens_hsa047132.67053974
8Morphine addiction_Homo sapiens_hsa050322.63356264
9Taste transduction_Homo sapiens_hsa047422.60062811
10Amphetamine addiction_Homo sapiens_hsa050312.59852917
11Insulin secretion_Homo sapiens_hsa049112.59079182
12Allograft rejection_Homo sapiens_hsa053302.55624171
13Autoimmune thyroid disease_Homo sapiens_hsa053202.44761761
14Olfactory transduction_Homo sapiens_hsa047402.39675347
15Graft-versus-host disease_Homo sapiens_hsa053322.33948595
16Long-term potentiation_Homo sapiens_hsa047202.27049600
17Intestinal immune network for IgA production_Homo sapiens_hsa046722.26953363
18Glutamatergic synapse_Homo sapiens_hsa047242.24099646
19Serotonergic synapse_Homo sapiens_hsa047262.14454835
20Dopaminergic synapse_Homo sapiens_hsa047282.14228416
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.06038026
22Basal transcription factors_Homo sapiens_hsa030221.94588167
23Cocaine addiction_Homo sapiens_hsa050301.93819366
24Vibrio cholerae infection_Homo sapiens_hsa051101.91731090
25Oxidative phosphorylation_Homo sapiens_hsa001901.84498727
26Renin secretion_Homo sapiens_hsa049241.83900075
27Salivary secretion_Homo sapiens_hsa049701.79124949
28Nitrogen metabolism_Homo sapiens_hsa009101.77824707
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.72759283
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.69357136
31Cholinergic synapse_Homo sapiens_hsa047251.67952939
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.66562047
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58212210
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.57936642
35Calcium signaling pathway_Homo sapiens_hsa040201.55363266
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55155807
37Long-term depression_Homo sapiens_hsa047301.50346001
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.49300944
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.35079828
40Alzheimers disease_Homo sapiens_hsa050101.30379177
41Parkinsons disease_Homo sapiens_hsa050121.27877684
42Caffeine metabolism_Homo sapiens_hsa002321.27411268
43Peroxisome_Homo sapiens_hsa041461.26195913
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.24847049
45Gastric acid secretion_Homo sapiens_hsa049711.21755080
46Type II diabetes mellitus_Homo sapiens_hsa049301.19496644
47Cardiac muscle contraction_Homo sapiens_hsa042601.18902853
48Folate biosynthesis_Homo sapiens_hsa007901.16885103
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.16342663
50Staphylococcus aureus infection_Homo sapiens_hsa051501.15549803
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14881456
52Fat digestion and absorption_Homo sapiens_hsa049751.14637735
53Oxytocin signaling pathway_Homo sapiens_hsa049211.13836195
54Gap junction_Homo sapiens_hsa045401.13632475
55Phototransduction_Homo sapiens_hsa047441.13490722
56ABC transporters_Homo sapiens_hsa020101.12326138
57Primary bile acid biosynthesis_Homo sapiens_hsa001201.08666006
58Linoleic acid metabolism_Homo sapiens_hsa005911.03875939
59RNA degradation_Homo sapiens_hsa030181.03720865
60cAMP signaling pathway_Homo sapiens_hsa040240.99983535
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98263866
62Axon guidance_Homo sapiens_hsa043600.96648810
63GnRH signaling pathway_Homo sapiens_hsa049120.93714700
64Bile secretion_Homo sapiens_hsa049760.90889998
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90791006
66Antigen processing and presentation_Homo sapiens_hsa046120.90415256
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.90223679
68Tyrosine metabolism_Homo sapiens_hsa003500.85242012
69Huntingtons disease_Homo sapiens_hsa050160.82729823
70Dorso-ventral axis formation_Homo sapiens_hsa043200.79886998
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78597107
72Arginine biosynthesis_Homo sapiens_hsa002200.76493105
73Melanogenesis_Homo sapiens_hsa049160.74105579
74Systemic lupus erythematosus_Homo sapiens_hsa053220.72500907
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72342725
76ErbB signaling pathway_Homo sapiens_hsa040120.71021918
77Type I diabetes mellitus_Homo sapiens_hsa049400.69888000
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68340262
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68207547
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67989799
81Estrogen signaling pathway_Homo sapiens_hsa049150.67546961
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65590836
83Protein export_Homo sapiens_hsa030600.65208341
84Viral myocarditis_Homo sapiens_hsa054160.65147054
85Pancreatic secretion_Homo sapiens_hsa049720.63400155
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62523579
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61685895
88Oocyte meiosis_Homo sapiens_hsa041140.61430182
89Rheumatoid arthritis_Homo sapiens_hsa053230.59413708
90Circadian rhythm_Homo sapiens_hsa047100.56321198
91Glioma_Homo sapiens_hsa052140.55166233
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55143683
93Thyroid hormone synthesis_Homo sapiens_hsa049180.53816669
94Dilated cardiomyopathy_Homo sapiens_hsa054140.51783740
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51733559
96Glucagon signaling pathway_Homo sapiens_hsa049220.51654098
97Alcoholism_Homo sapiens_hsa050340.50968303
98Ether lipid metabolism_Homo sapiens_hsa005650.49824772
99MAPK signaling pathway_Homo sapiens_hsa040100.49816319
100Phagosome_Homo sapiens_hsa041450.49705315
101Prion diseases_Homo sapiens_hsa050200.48517906
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47634198
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47330169
104Chemical carcinogenesis_Homo sapiens_hsa052040.45632181
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41909865
106Ras signaling pathway_Homo sapiens_hsa040140.41609812
107Butanoate metabolism_Homo sapiens_hsa006500.41086760
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39627246
109Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38925902
110Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38594029
111Inositol phosphate metabolism_Homo sapiens_hsa005620.38515463
112Regulation of autophagy_Homo sapiens_hsa041400.38195531
113Sulfur metabolism_Homo sapiens_hsa009200.38126257
114Fatty acid elongation_Homo sapiens_hsa000620.37835251
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36108320
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34207871
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33610013
118Ovarian steroidogenesis_Homo sapiens_hsa049130.32533028
119Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.32397381
120Pyruvate metabolism_Homo sapiens_hsa006200.31564582
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30963651
122Wnt signaling pathway_Homo sapiens_hsa043100.30189692
123Choline metabolism in cancer_Homo sapiens_hsa052310.29896841
124Arachidonic acid metabolism_Homo sapiens_hsa005900.28038725
125Endometrial cancer_Homo sapiens_hsa052130.26895031
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26210311
127Metabolic pathways_Homo sapiens_hsa011000.25655970
128Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22228079
129Sphingolipid metabolism_Homo sapiens_hsa006000.21059699
130Mineral absorption_Homo sapiens_hsa049780.20576011
131Glycerolipid metabolism_Homo sapiens_hsa005610.20234538
132Rap1 signaling pathway_Homo sapiens_hsa040150.20077079
133Melanoma_Homo sapiens_hsa052180.19954289
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.17883870
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.17499627

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