SGK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1microglial cell activation (GO:0001774)5.41165971
2G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.32864744
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.11760650
4macrophage activation involved in immune response (GO:0002281)4.79555369
5positive regulation of chemokine secretion (GO:0090197)4.39605623
6lymph vessel development (GO:0001945)4.25498542
7regulation of interferon-beta biosynthetic process (GO:0045357)4.25219804
8regulation of chemokine secretion (GO:0090196)4.19211707
9macrophage activation (GO:0042116)4.02410793
10negative regulation of complement activation (GO:0045916)3.97680697
11cellular response to thyroid hormone stimulus (GO:0097067)3.84956935
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.79728205
13positive regulation by organism of defense response of other organism involved in symbiotic interact3.79728205
14modulation by symbiont of host immune response (GO:0052553)3.79728205
15positive regulation by symbiont of host defense response (GO:0052509)3.79728205
16modulation by symbiont of host defense response (GO:0052031)3.79728205
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.79728205
18keratan sulfate catabolic process (GO:0042340)3.74725599
19basement membrane organization (GO:0071711)3.68170121
20adhesion of symbiont to host (GO:0044406)3.63961577
21oligosaccharide catabolic process (GO:0009313)3.58701871
22negative regulation of protein activation cascade (GO:2000258)3.58348055
23neutrophil activation involved in immune response (GO:0002283)3.55211202
24cellular extravasation (GO:0045123)3.48837338
25G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.44836225
26endothelial cell morphogenesis (GO:0001886)3.42267959
27positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.40619995
28positive regulation of p38MAPK cascade (GO:1900745)3.37877516
29lipopolysaccharide-mediated signaling pathway (GO:0031663)3.32259374
30melanin biosynthetic process (GO:0042438)3.30912532
31positive regulation of odontogenesis (GO:0042482)3.30146814
32response to peptidoglycan (GO:0032494)3.29976168
33negative regulation of humoral immune response (GO:0002921)3.27453663
34purinergic nucleotide receptor signaling pathway (GO:0035590)3.23689899
35transcytosis (GO:0045056)3.22579890
36positive regulation of interferon-alpha production (GO:0032727)3.20620301
37detection of molecule of bacterial origin (GO:0032490)3.20524969
38apoptotic cell clearance (GO:0043277)3.20429339
39regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.19494907
40glycosphingolipid catabolic process (GO:0046479)3.19371756
41response to thyroid hormone (GO:0097066)3.14819851
42response to laminar fluid shear stress (GO:0034616)3.12952617
43cellular response to epinephrine stimulus (GO:0071872)3.10655829
44endothelium development (GO:0003158)3.09067895
45regulation of endothelial cell differentiation (GO:0045601)3.08424401
46regulation of interleukin-12 biosynthetic process (GO:0045075)3.06009883
47glycolipid catabolic process (GO:0019377)3.04884671
48wound healing, spreading of epidermal cells (GO:0035313)3.01020072
49iron ion import (GO:0097286)3.00393329
50positive regulation of cellular amide metabolic process (GO:0034250)2.99628317
51glomerular visceral epithelial cell development (GO:0072015)2.98748856
52regulation of interferon-alpha production (GO:0032647)2.96974468
53melanin metabolic process (GO:0006582)2.96040303
54lymphangiogenesis (GO:0001946)2.92198121
55cell adhesion mediated by integrin (GO:0033627)2.91919276
56ovulation from ovarian follicle (GO:0001542)2.88975949
57response to epinephrine (GO:0071871)2.88917456
58positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.87386822
59negative regulation of mast cell activation (GO:0033004)2.87348006
60adenosine receptor signaling pathway (GO:0001973)2.86972208
61phenylpropanoid metabolic process (GO:0009698)2.83384354
62vascular endothelial growth factor signaling pathway (GO:0038084)2.83351672
63positive regulation of astrocyte differentiation (GO:0048711)2.82497937
64detection of external biotic stimulus (GO:0098581)2.82452056
65protein localization to endosome (GO:0036010)2.82332674
66establishment of endothelial barrier (GO:0061028)2.82308285
67regulation of mononuclear cell migration (GO:0071675)2.80529485
68pinocytosis (GO:0006907)2.80083544
69virion attachment to host cell (GO:0019062)2.79518025
70adhesion of symbiont to host cell (GO:0044650)2.79518025
71positive regulation of macrophage cytokine production (GO:0060907)2.78898423
72negative regulation of interleukin-12 production (GO:0032695)2.78065688
73I-kappaB phosphorylation (GO:0007252)2.76783267
74phagocytosis, recognition (GO:0006910)2.75171473
75macrophage chemotaxis (GO:0048246)2.74778990
76histamine secretion (GO:0001821)2.72192712
77mannose metabolic process (GO:0006013)2.71912094
78regulation of cholesterol storage (GO:0010885)2.71246273
79embryonic process involved in female pregnancy (GO:0060136)2.69990628
80peptide catabolic process (GO:0043171)2.67426430
81cGMP-mediated signaling (GO:0019934)2.67278267
82detection of other organism (GO:0098543)2.66898913
83regulation of chemokine-mediated signaling pathway (GO:0070099)2.66259261
84ceramide catabolic process (GO:0046514)2.64630202
85retina vasculature morphogenesis in camera-type eye (GO:0061299)2.63684518
86regulation of vitamin D biosynthetic process (GO:0060556)2.63471730
87regulation of p38MAPK cascade (GO:1900744)2.63252745
88positive regulation of interferon-beta production (GO:0032728)2.62380279
89cyclooxygenase pathway (GO:0019371)2.62099174
90positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.60566566
91cellular response to interleukin-6 (GO:0071354)2.59370938
92phagocytosis, engulfment (GO:0006911)2.57676175
93positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.56880688
94regulation of integrin-mediated signaling pathway (GO:2001044)2.56630909
95detection of biotic stimulus (GO:0009595)2.56340092
96positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.56243059
97amino sugar catabolic process (GO:0046348)2.56178944
98renal filtration (GO:0097205)2.55424386
99regulation of vitamin metabolic process (GO:0030656)2.54855669
100cellular response to ethanol (GO:0071361)2.54448761
101response to fluid shear stress (GO:0034405)2.54063481
102angiotensin maturation (GO:0002003)2.53809946
103protein kinase C signaling (GO:0070528)2.53282206
104purinergic receptor signaling pathway (GO:0035587)2.52536321
105positive regulation of receptor recycling (GO:0001921)2.52233403
106low-density lipoprotein particle clearance (GO:0034383)2.51146454
107regulation of macrophage chemotaxis (GO:0010758)2.50738075
108secondary metabolite biosynthetic process (GO:0044550)2.50350223
109regulation of monocyte chemotaxis (GO:0090025)2.50043435
110glomerular epithelial cell development (GO:0072310)2.49981246
111positive regulation of endothelial cell differentiation (GO:0045603)2.49252267
112membrane lipid catabolic process (GO:0046466)2.48425119
113negative regulation of interleukin-6 production (GO:0032715)2.47647680
114response to muramyl dipeptide (GO:0032495)2.44713251
115T-helper 1 type immune response (GO:0042088)2.44287222
116superoxide anion generation (GO:0042554)2.44155054
117positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.43967399
118neutrophil activation (GO:0042119)2.43854700
119myeloid cell activation involved in immune response (GO:0002275)2.43554157
120osteoclast differentiation (GO:0030316)2.42964570
121negative regulation of interleukin-8 production (GO:0032717)2.42307038
122platelet-derived growth factor receptor signaling pathway (GO:0048008)2.42304364
123regulation of mast cell activation involved in immune response (GO:0033006)2.42028097
124interleukin-6-mediated signaling pathway (GO:0070102)2.41765762
125regulation of platelet activation (GO:0010543)2.41559987
126urea cycle (GO:0000050)2.41539197
127negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.41450856
128germinal center formation (GO:0002467)2.40453117
129regulation of podosome assembly (GO:0071801)2.39262932
130interleukin-1-mediated signaling pathway (GO:0070498)2.39161103
131regulation of T-helper 2 cell differentiation (GO:0045628)2.38663116
132surfactant homeostasis (GO:0043129)2.38373393
133cellular response to arsenic-containing substance (GO:0071243)2.37926266
134glomerular filtration (GO:0003094)2.37858666
135granulocyte activation (GO:0036230)2.36872752
136positive regulation of cholesterol efflux (GO:0010875)2.36337278
137positive regulation of monocyte chemotaxis (GO:0090026)2.35771298
138hemidesmosome assembly (GO:0031581)2.35739759
139regulation of B cell receptor signaling pathway (GO:0050855)2.34943000
140negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.34683867
141protein kinase B signaling (GO:0043491)2.34431611
142neutrophil chemotaxis (GO:0030593)2.34424612
143vitamin transmembrane transport (GO:0035461)2.34380778
144positive regulation of vasculogenesis (GO:2001214)2.34325192
145sphingolipid catabolic process (GO:0030149)2.34198585
146negative regulation of protein autophosphorylation (GO:0031953)2.34008588
147prostaglandin metabolic process (GO:0006693)2.33948050
148prostanoid metabolic process (GO:0006692)2.33948050
149positive regulation of osteoblast proliferation (GO:0033690)2.32752313
150pathway-restricted SMAD protein phosphorylation (GO:0060389)2.32477520
151cellular response to reactive nitrogen species (GO:1902170)2.30660628
152negative regulation of erythrocyte differentiation (GO:0045647)2.28709338
153neutrophil migration (GO:1990266)2.27704283
154regulation of interleukin-8 biosynthetic process (GO:0045414)2.27542411
155Rap protein signal transduction (GO:0032486)2.25238357
156regulation of membrane protein ectodomain proteolysis (GO:0051043)2.25094671
157production of molecular mediator involved in inflammatory response (GO:0002532)2.24334806
158regulation of macrophage cytokine production (GO:0010935)2.22985310
159positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.22925689
160negative regulation of interleukin-1 beta production (GO:0032691)2.21947951
161granulocyte chemotaxis (GO:0071621)2.21878653
162barbed-end actin filament capping (GO:0051016)2.20978371
163regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.20803960
164antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.20714853
165antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.18819853
166regulation of complement activation (GO:0030449)2.18344925
167positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.18060786

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.21149452
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.00875315
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.31079635
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.02879525
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.02879525
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.02879525
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.97340521
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.89689027
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.82798248
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.62720169
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.55331949
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.54908294
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.54412009
14GATA2_21666600_ChIP-Seq_HMVEC_Human2.48656521
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.42498430
16* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.42250331
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.41855600
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.36289738
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.32393734
20* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32178875
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.25319218
22* ESR2_21235772_ChIP-Seq_MCF-7_Human2.24321990
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.12639504
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.09845755
25CLOCK_20551151_ChIP-Seq_293T_Human2.09075669
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.91237323
27SALL4_18804426_ChIP-ChIP_XEN_Mouse1.90979549
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.87465541
29CJUN_26792858_Chip-Seq_BT549_Human1.83468437
30SOX2_20726797_ChIP-Seq_SW620_Human1.83289465
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.82442803
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80802474
33FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.80738736
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.76324250
35SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.73582533
36* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72269221
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.72102639
38* LXR_22158963_ChIP-Seq_LIVER_Mouse1.68932449
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.68700223
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68047676
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.63106190
42* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62997448
43CDX2_20551321_ChIP-Seq_CACO-2_Human1.60753389
44ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.58787276
45* RUNX_20019798_ChIP-Seq_JUKART_Human1.54848517
46SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.52184311
47SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.52184311
48VDR_24763502_ChIP-Seq_THP-1_Human1.51251017
49* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.50701828
50FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.50077354
51STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.49811401
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49780491
53ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.48796643
54STAT4_19710469_ChIP-ChIP_TH1__Mouse1.47879021
55RXR_22158963_ChIP-Seq_LIVER_Mouse1.45728489
56PPARA_22158963_ChIP-Seq_LIVER_Mouse1.44770455
57TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43663863
58JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42471711
59JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42426080
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42024770
61VDR_24787735_ChIP-Seq_THP-1_Human1.36803891
62ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.36687484
63TCF3_18692474_ChIP-Seq_MEFs_Mouse1.36389440
64CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.34797736
65* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.33714866
66* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.33153393
67* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.33153393
68* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32359093
69PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31002685
70* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30304554
71TBX20_22080862_ChIP-Seq_HEART_Mouse1.28871682
72TBX20_22328084_ChIP-Seq_HEART_Mouse1.28871682
73ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.27936604
74* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.27651356
75VDR_21846776_ChIP-Seq_THP-1_Human1.23265342
76* PU_27001747_Chip-Seq_BMDM_Mouse1.22824906
77NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.21663377
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21313385
79SCL_19346495_ChIP-Seq_HPC-7_Human1.20504637
80FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.20079709
81IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16611455
82TCF7_22412390_ChIP-Seq_EML_Mouse1.16500681
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16108361
84* ELK3_25401928_ChIP-Seq_HUVEC_Human1.16106798
85SOX9_24532713_ChIP-Seq_HFSC_Mouse1.15692462
86WT1_19549856_ChIP-ChIP_CCG9911_Human1.15543880
87RUNX1_22412390_ChIP-Seq_EML_Mouse1.15224978
88* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11414421
89CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11389303
90AHR_22903824_ChIP-Seq_MCF-7_Human1.10723674
91SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.10529794
92CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09767341
93NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09380223
94* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09026764
95RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09018620
96TCF4_18268006_ChIP-ChIP_LS174T_Human1.08642941
97GATA1_22025678_ChIP-Seq_K562_Human1.08226095
98* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07764990
99* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06879711
100TFEB_21752829_ChIP-Seq_HELA_Human1.05251370
101* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02767750
102LXR_22292898_ChIP-Seq_THP-1_Human1.02690910
103SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02277539
104NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02220129
105NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.01455410
106ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01176447
107KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00328342
108RACK7_27058665_Chip-Seq_MCF-7_Human1.00189858
109KDM2B_26808549_Chip-Seq_DND41_Human1.00139071
110TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99353307
111EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99167900
112PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.97220640
113P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96967156
114SPI1_23547873_ChIP-Seq_NB4_Human0.96906696
115ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96488839
116* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.95953129
117EP300_21415370_ChIP-Seq_HL-1_Mouse0.94217715
118KLF5_25053715_ChIP-Seq_YYC3_Human0.92616130
119* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92098706
120ZNF263_19887448_ChIP-Seq_K562_Human0.90565197
121SMAD3_21741376_ChIP-Seq_HESCs_Human0.89344393
122* TP63_23658742_ChIP-Seq_EP156T_Human0.87578927
123UBF1/2_26484160_Chip-Seq_HMECs_Human0.87459713
124TP53_16413492_ChIP-PET_HCT116_Human0.87388894
125NANOG_18692474_ChIP-Seq_MEFs_Mouse0.87258413
126SPI1_23127762_ChIP-Seq_K562_Human0.86961674
127RXR_22108803_ChIP-Seq_LS180_Human0.86908674
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86250346
129BRD4_25478319_ChIP-Seq_HGPS_Human0.86131847
130KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86025119
131TP53_18474530_ChIP-ChIP_U2OS_Human0.85398266
132VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.82083280
133ARNT_22903824_ChIP-Seq_MCF-7_Human0.81696872
134GATA1_19941826_ChIP-Seq_K562_Human0.79028929
135SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78459428

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005167_abnormal_blood-brain_barrier3.66626646
2MP0003191_abnormal_cellular_cholesterol3.44778166
3MP0003724_increased_susceptibility_to3.26660368
4MP0006082_CNS_inflammation3.21876208
5MP0001879_abnormal_lymphatic_vessel2.95086854
6MP0010368_abnormal_lymphatic_system2.72268552
7MP0008438_abnormal_cutaneous_collagen2.59837422
8MP0004883_abnormal_blood_vessel2.45852786
9MP0006054_spinal_hemorrhage2.38737992
10MP0004272_abnormal_basement_membrane2.36024262
11MP0003828_pulmonary_edema2.31096241
12MP0005058_abnormal_lysosome_morphology2.28351972
13MP0003279_aneurysm2.18967187
14MP0005164_abnormal_response_to2.13082671
15MP0002148_abnormal_hypersensitivity_rea2.10154538
16MP0003075_altered_response_to2.02408199
17MP0003950_abnormal_plasma_membrane2.02097275
18MP0003566_abnormal_cell_adhesion1.99814034
19MP0002254_reproductive_system_inflammat1.99272516
20MP0003690_abnormal_glial_cell1.98808599
21MP0000343_altered_response_to1.95117434
22MP0000015_abnormal_ear_pigmentation1.92723283
23MP0001835_abnormal_antigen_presentation1.91778996
24MP0008260_abnormal_autophagy1.89278482
25MP0001851_eye_inflammation1.88306372
26MP0001533_abnormal_skeleton_physiology1.88244876
27MP0002419_abnormal_innate_immunity1.87019795
28MP0003436_decreased_susceptibility_to1.86413723
29MP0003705_abnormal_hypodermis_morpholog1.86407782
30MP0000604_amyloidosis1.78431393
31MP0010234_abnormal_vibrissa_follicle1.76124193
32MP0008004_abnormal_stomach_pH1.75810215
33MP0002998_abnormal_bone_remodeling1.75781606
34MP0005166_decreased_susceptibility_to1.75042062
35MP0000767_abnormal_smooth_muscle1.73230081
36MP0003303_peritoneal_inflammation1.72674131
37MP0005257_abnormal_intraocular_pressure1.71910784
38MP0001542_abnormal_bone_strength1.71048753
39MP0000569_abnormal_digit_pigmentation1.68746867
40MP0002090_abnormal_vision1.64865185
41MP0005623_abnormal_meninges_morphology1.57384772
42MP0005083_abnormal_biliary_tract1.57136345
43MP0005464_abnormal_platelet_physiology1.55668817
44MP0001853_heart_inflammation1.55504585
45MP0002009_preneoplasia1.52189875
46MP0000685_abnormal_immune_system1.51614808
47MP0005409_darkened_coat_color1.51516279
48MP0000249_abnormal_blood_vessel1.50705348
49MP0005023_abnormal_wound_healing1.50309222
50MP0000371_diluted_coat_color1.49769466
51MP0009278_abnormal_bone_marrow1.46420461
52MP0003448_altered_tumor_morphology1.45733411
53MP0003091_abnormal_cell_migration1.45258367
54MP0003172_abnormal_lysosome_physiology1.44938365
55MP0003045_fibrosis1.44696146
56MP0005408_hypopigmentation1.42146686
57MP0001790_abnormal_immune_system1.41666482
58MP0005387_immune_system_phenotype1.41666482
59MP0005171_absent_coat_pigmentation1.41587078
60MP0000372_irregular_coat_pigmentation1.41141071
61MP0001958_emphysema1.39245007
62MP0005451_abnormal_body_composition1.38273218
63MP0005000_abnormal_immune_tolerance1.34757389
64MP0003136_yellow_coat_color1.33587837
65MP0002295_abnormal_pulmonary_circulatio1.32399270
66MP0000465_gastrointestinal_hemorrhage1.31197254
67MP0005365_abnormal_bile_salt1.28882390
68MP0005390_skeleton_phenotype1.28313180
69MP0009785_altered_susceptibility_to1.27695481
70MP0003453_abnormal_keratinocyte_physiol1.27473058
71MP0003300_gastrointestinal_ulcer1.26711066
72MP0003329_amyloid_beta_deposits1.26652746
73MP0005085_abnormal_gallbladder_physiolo1.26457852
74MP0004381_abnormal_hair_follicle1.25371449
75MP0005360_urolithiasis1.24338687
76MP0002452_abnormal_antigen_presenting1.23846401
77MP0005174_abnormal_tail_pigmentation1.23746398
78MP0005275_abnormal_skin_tensile1.21721763
79MP0000750_abnormal_muscle_regeneration1.20721990
80MP0005165_increased_susceptibility_to1.19897631
81MP0004947_skin_inflammation1.19225287
82MP0004233_abnormal_muscle_weight1.18053189
83MP0001915_intracranial_hemorrhage1.16209361
84MP0005503_abnormal_tendon_morphology1.14948552
85MP0002933_joint_inflammation1.14709069
86MP0000858_altered_metastatic_potential1.13677004
87MP0001800_abnormal_humoral_immune1.11931180
88MP0009764_decreased_sensitivity_to1.11885662
89MP0004484_altered_response_of1.09820298
90MP0002166_altered_tumor_susceptibility1.06181360
91MP0003941_abnormal_skin_development1.04799928
92MP0002405_respiratory_system_inflammati1.04464703
93MP0003183_abnormal_peptide_metabolism0.98883314
94MP0002723_abnormal_immune_serum0.98772913
95MP0005508_abnormal_skeleton_morphology0.98114198
96MP0003795_abnormal_bone_structure0.97989418
97MP0005671_abnormal_response_to0.97335129
98MP0005595_abnormal_vascular_smooth0.97063445
99MP0002896_abnormal_bone_mineralization0.94089359
100MP0009840_abnormal_foam_cell0.93217679
101MP0001845_abnormal_inflammatory_respons0.92740300
102MP0002332_abnormal_exercise_endurance0.92415018
103MP0004019_abnormal_vitamin_homeostasis0.91892733
104MP0000920_abnormal_myelination0.91633485
105MP0005025_abnormal_response_to0.91596433
106MP0005670_abnormal_white_adipose0.91218970
107MP0010155_abnormal_intestine_physiology0.90706717
108MP0010352_gastrointestinal_tract_polyps0.89416815
109MP0002877_abnormal_melanocyte_morpholog0.89210714
110MP0001614_abnormal_blood_vessel0.88358540
111MP0005310_abnormal_salivary_gland0.87167866
112MP0002060_abnormal_skin_morphology0.87044488
113MP0004808_abnormal_hematopoietic_stem0.85209752
114MP0003656_abnormal_erythrocyte_physiolo0.84965540
115MP0005076_abnormal_cell_differentiation0.84926711
116MP0001819_abnormal_immune_cell0.82714771
117MP0002420_abnormal_adaptive_immunity0.80316207
118* MP0002136_abnormal_kidney_physiology0.79906662
119MP0008469_abnormal_protein_level0.79318168
120MP0000733_abnormal_muscle_development0.77580782
121MP0002139_abnormal_hepatobiliary_system0.74778258
122MP0002925_abnormal_cardiovascular_devel0.74084804
123MP0002115_abnormal_skeleton_extremities0.72313612
124MP0001756_abnormal_urination0.71240903
125MP0002132_abnormal_respiratory_system0.70435869
126MP0009115_abnormal_fat_cell0.69674013
127MP0005388_respiratory_system_phenotype0.69151687
128MP0002133_abnormal_respiratory_system0.69151687
129MP0002075_abnormal_coat/hair_pigmentati0.69148534
130MP0005367_renal/urinary_system_phenotyp0.66372583
131MP0000516_abnormal_urinary_system0.66372583
132MP0001873_stomach_inflammation0.66035582
133MP0002796_impaired_skin_barrier0.65185984

Predicted human phenotypes

RankGene SetZ-score
1Axonal loss (HP:0003447)4.14529761
2Systemic lupus erythematosus (HP:0002725)3.93335893
3Abnormality of glycolipid metabolism (HP:0010969)3.81296778
4Abnormality of liposaccharide metabolism (HP:0010968)3.81296778
5Abnormality of glycosphingolipid metabolism (HP:0004343)3.81296778
6Glomerulonephritis (HP:0000099)3.74684785
7Hematochezia (HP:0002573)3.63049727
8Urethral obstruction (HP:0000796)3.61616889
9Arterial tortuosity (HP:0005116)3.39799717
10Vascular tortuosity (HP:0004948)3.39340305
11Recurrent abscess formation (HP:0002722)3.33462696
12White forelock (HP:0002211)3.32669422
13Aortic aneurysm (HP:0004942)3.31510805
14Eczematoid dermatitis (HP:0000976)3.22431139
15Epiphyseal dysplasia (HP:0002656)3.12619878
16Increased cerebral lipofuscin (HP:0011813)3.06352316
17Malnutrition (HP:0004395)3.05123519
18Increased neuronal autofluorescent lipopigment (HP:0002074)3.03420798
19Cerebral aneurysm (HP:0004944)3.02235918
20Distal lower limb muscle weakness (HP:0009053)3.00751755
21Aortic dissection (HP:0002647)2.99503379
22Urinary glycosaminoglycan excretion (HP:0003541)2.99315048
23Mucopolysacchariduria (HP:0008155)2.99315048
24Loss of speech (HP:0002371)2.97242172
25Abnormality of polysaccharide metabolism (HP:0011012)2.96652514
26Abnormality of glycosaminoglycan metabolism (HP:0004371)2.96652514
27Abnormality of mucopolysaccharide metabolism (HP:0011020)2.96652514
28Thick nail (HP:0001805)2.95809673
29Segmental peripheral demyelination/remyelination (HP:0003481)2.94879249
30Premature rupture of membranes (HP:0001788)2.93322786
31Patchy hypopigmentation of hair (HP:0011365)2.93257786
32Autoimmune thrombocytopenia (HP:0001973)2.88094961
33Vacuolated lymphocytes (HP:0001922)2.86286044
34Abnormality of glutamine family amino acid metabolism (HP:0010902)2.77646581
35Cupped ribs (HP:0000887)2.77557179
36Recurrent bacterial skin infections (HP:0005406)2.74163271
37Osteolytic defects of the hand bones (HP:0009699)2.71050086
38Osteolytic defects of the phalanges of the hand (HP:0009771)2.71050086
39Abnormality of the periventricular white matter (HP:0002518)2.69679355
40Blue irides (HP:0000635)2.65429765
41Abnormality of macrophages (HP:0004311)2.55425425
42Prostate neoplasm (HP:0100787)2.53452523
43Vertebral compression fractures (HP:0002953)2.52286150
44Retinal atrophy (HP:0001105)2.48495608
45Neurofibrillary tangles (HP:0002185)2.47715566
46Alopecia of scalp (HP:0002293)2.47050688
47Mutism (HP:0002300)2.45251716
48Nephritis (HP:0000123)2.41581887
49Absent hand (HP:0004050)2.37058256
50Asymmetric septal hypertrophy (HP:0001670)2.36071586
51Hypoplastic ischia (HP:0003175)2.35682511
52Adactyly (HP:0009776)2.30060294
53Mitral stenosis (HP:0001718)2.28863213
54Ocular albinism (HP:0001107)2.28576992
55Congenital, generalized hypertrichosis (HP:0004540)2.26037202
56Increased CSF protein (HP:0002922)2.23818172
57Cervical subluxation (HP:0003308)2.21677580
58Increased connective tissue (HP:0009025)2.20055257
59Abnormality of the ischium (HP:0003174)2.18994992
60Congenital sensorineural hearing impairment (HP:0008527)2.17192860
61Atrophic scars (HP:0001075)2.16494134
62Metaphyseal cupping (HP:0003021)2.15354999
63Premature loss of primary teeth (HP:0006323)2.15288559
64Vitreoretinal degeneration (HP:0000655)2.14687159
65Bilateral sensorineural hearing impairment (HP:0008619)2.12368563
66Absent toe (HP:0010760)2.09292024
67Muscle fiber splitting (HP:0003555)2.08874448
68Progressive visual loss (HP:0000529)2.08098679
69Skin nodule (HP:0200036)2.06393864
70Xanthomatosis (HP:0000991)2.05890641
71Esophageal varix (HP:0002040)2.05525073
72Interstitial pulmonary disease (HP:0006530)2.05182493
73Cardiovascular calcification (HP:0011915)2.04478169
74Irregular epiphyses (HP:0010582)1.99657949
75Gingivitis (HP:0000230)1.99103760
76Elevated erythrocyte sedimentation rate (HP:0003565)1.97939669
77Protrusio acetabuli (HP:0003179)1.97766619
78Vascular calcification (HP:0004934)1.97725278
79Agnosia (HP:0010524)1.97251068
80Distal lower limb amyotrophy (HP:0008944)1.96933064
81Albinism (HP:0001022)1.94670758
82Recurrent gram-negative bacterial infections (HP:0005420)1.93556768
83Cerebral inclusion bodies (HP:0100314)1.93540844
84Dysostosis multiplex (HP:0000943)1.93287247
85Subacute progressive viral hepatitis (HP:0006572)1.92937095
86Myositis (HP:0100614)1.92690177
87Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.92666830
88Abnormality of monocarboxylic acid metabolism (HP:0010996)1.91761457
89Epidermoid cyst (HP:0200040)1.91071955
90Peripheral demyelination (HP:0011096)1.91042692
91Generalized hypopigmentation of hair (HP:0011358)1.88731324
92Short hallux (HP:0010109)1.88636875
93Amyloidosis (HP:0011034)1.88308214
94Small epiphyses (HP:0010585)1.87829550
95Myocardial infarction (HP:0001658)1.84025567
96J-shaped sella turcica (HP:0002680)1.83586615
97Disinhibition (HP:0000734)1.83452774
98Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.82741017
99Spondylolisthesis (HP:0003302)1.82376273
100Orchitis (HP:0100796)1.82330771
101Ileus (HP:0002595)1.80905528
102Facial diplegia (HP:0001349)1.80380984
103Flat acetabular roof (HP:0003180)1.80348470
104Upper motor neuron abnormality (HP:0002127)1.80040565
105Impaired platelet aggregation (HP:0003540)1.79168001
106Abnormal platelet function (HP:0011869)1.79168001
107Aplasia/Hypoplasia of the hallux (HP:0008362)1.77861890
108Neuronal loss in central nervous system (HP:0002529)1.77770217
109Ovoid vertebral bodies (HP:0003300)1.77709772
110Neoplasm of head and neck (HP:0012288)1.76958876
111Esophageal neoplasm (HP:0100751)1.76958876
112Complement deficiency (HP:0004431)1.76910525
113Recurrent skin infections (HP:0001581)1.75539520
114Tetany (HP:0001281)1.75263892
115Optic neuritis (HP:0100653)1.74638861
116Retrobulbar optic neuritis (HP:0100654)1.74638861
117Choroideremia (HP:0001139)1.74558307
118Mediastinal lymphadenopathy (HP:0100721)1.74462686
119Autoimmune hemolytic anemia (HP:0001890)1.73557508
120Colitis (HP:0002583)1.73342779
121Increased serum ferritin (HP:0003281)1.72216174
122Abnormality of the distal phalanges of the toes (HP:0010182)1.71996937
123Global brain atrophy (HP:0002283)1.71528776
124Scanning speech (HP:0002168)1.69965618
125Aplasia involving bones of the extremities (HP:0009825)1.69709296
126Aplasia involving bones of the upper limbs (HP:0009823)1.69709296
127Aplasia of the phalanges of the hand (HP:0009802)1.69709296
128Hypoplasia of the iris (HP:0007676)1.68981822
129Abnormal tarsal ossification (HP:0008369)1.68960324
130Onion bulb formation (HP:0003383)1.68337416
131Stomatitis (HP:0010280)1.68021399
132Follicular hyperkeratosis (HP:0007502)1.66983765
133Osteomyelitis (HP:0002754)1.66982512
134Abnormality of complement system (HP:0005339)1.66412863
135Steatorrhea (HP:0002570)1.65840433
136Spinal rigidity (HP:0003306)1.65801222
137Thin bony cortex (HP:0002753)1.63277246
138Iris hypopigmentation (HP:0007730)1.62208405
139Spontaneous hematomas (HP:0007420)1.61169986
140Elbow flexion contracture (HP:0002987)1.60964609
141Absent frontal sinuses (HP:0002688)1.60433402
142Camptodactyly of toe (HP:0001836)1.59731328
143Joint stiffness (HP:0001387)1.59693794
144Abnormality of proline metabolism (HP:0010907)1.59350233
145Hydroxyprolinuria (HP:0003080)1.59350233
146Stomach cancer (HP:0012126)1.58855034
147Periodontitis (HP:0000704)1.58766942
148Tetraparesis (HP:0002273)1.58252250
149Abnormality of the vasculature of the conjunctiva (HP:0008054)1.58177364
150Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.56973409
151Hypoplasia of the odontoid process (HP:0003311)1.56858078
152Upper limb muscle weakness (HP:0003484)1.55861928
153Abnormality of the nasal septum (HP:0000419)1.54228178
154Platyspondyly (HP:0000926)1.54041231

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR25.37150471
2TIE14.14135399
3AKT33.58940305
4BLK2.83813393
5KDR2.79813366
6EPHA22.72871646
7ERN12.69473031
8MAP3K142.69306638
9MAP3K32.63350517
10PRPF4B2.37518941
11NEK92.26732600
12TBK12.22330925
13ACVR1B2.15972151
14MAPK152.07171313
15FER1.98993685
16IRAK31.76157578
17RIPK41.74825683
18MAP2K21.73572338
19MST41.72615866
20ZAP701.71356025
21STK101.64244860
22TSSK61.56590396
23IKBKB1.54680225
24FRK1.53311847
25PBK1.48289342
26GRK71.41001629
27IRAK41.36283440
28MAP3K131.35674356
29IKBKE1.34644873
30MAP3K21.34472822
31PRKG21.33920166
32CSK1.31840080
33ICK1.27959316
34TTN1.27732410
35PAK41.26860714
36TGFBR11.26476703
37TRPM71.26174714
38STK391.26167525
39PAK21.18096681
40MAP3K11.15280034
41TYK21.14706380
42OXSR11.13399868
43PIK3CA1.13352151
44MST1R1.11180998
45DDR21.10225974
46GRK11.08839206
47TAOK21.05993032
48EPHB11.04861193
49IRAK11.04539587
50LATS11.02458648
51TXK1.01353085
52MET1.00815579
53MYLK0.99962685
54JAK10.99154050
55CDC42BPA0.98809298
56MATK0.97981746
57RPS6KA40.95540245
58MOS0.93931350
59EPHB20.93040891
60MAP2K30.92037094
61FGFR30.90949046
62BMX0.90564575
63PIM20.89685231
64RIPK10.87956948
65GSK3A0.87550037
66MAPKAPK30.86388620
67PTK60.85756669
68* PDPK10.84474404
69PIK3CG0.83116236
70CSF1R0.82541116
71FGFR40.79008016
72* MAPK70.78757163
73PDGFRB0.77744002
74EPHA30.75051403
75MAPK40.74711126
76INSR0.74617316
77PRKAA20.72476178
78IRAK20.72164532
79IGF1R0.71006889
80MAP4K10.70630691
81MELK0.69915212
82KSR20.69576523
83FES0.64452272
84MAPK110.64450671
85CHUK0.63726128
86MARK30.62838561
87PRKD10.62598348
88RPS6KA20.62345241
89CDK60.62220090
90MAP2K10.61850500
91MAP3K70.61324866
92CAMKK20.61223745
93PTK2B0.60547556
94CDK120.59677124
95HCK0.59598699
96SGK30.57927523
97EGFR0.57558237
98ERBB40.56823437
99* MTOR0.56530694
100MAPKAPK50.55195431
101ITK0.54954899
102JAK20.54906707
103MAP3K60.53055826
104TRIB30.52770160
105PRKD20.52711921
106* PDK20.52676016
107STK380.51925984
108PIM10.51900185
109RAF10.51333159
110* PDK10.51031603
111STK30.50992359
112CAMK1D0.50677553
113LMTK20.50469727
114BMPR20.49107734
115SYK0.49035008
116MAPKAPK20.47649854
117PDGFRA0.47405863
118BMPR1B0.46832529
119KIT0.46660192
120JAK30.45418539
121EIF2AK20.44690874
122ABL10.44277349
123ERBB30.42718930
124LATS20.41293595
125FGR0.40362288
126LCK0.38742359
127NLK0.37060423
128INSRR0.36840348
129PRKCD0.35867811
130PTK20.35411025
131* MAPK120.35359793
132PRKCH0.34802024
133ERBB20.32214253
134ABL20.31902216
135LYN0.31605759
136NUAK10.28656277
137BCKDK0.28162859
138PKN10.27409328
139PRKCE0.26223847

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.69429682
2Other glycan degradation_Homo sapiens_hsa005112.86216554
3Lysosome_Homo sapiens_hsa041422.69167216
4Staphylococcus aureus infection_Homo sapiens_hsa051502.59861435
5Leishmaniasis_Homo sapiens_hsa051402.17057817
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.16136319
7Osteoclast differentiation_Homo sapiens_hsa043802.05979877
8Rheumatoid arthritis_Homo sapiens_hsa053232.02589284
9Malaria_Homo sapiens_hsa051441.96899735
10Vitamin digestion and absorption_Homo sapiens_hsa049771.88404191
11Legionellosis_Homo sapiens_hsa051341.86891727
12ECM-receptor interaction_Homo sapiens_hsa045121.83330124
13Pertussis_Homo sapiens_hsa051331.79856358
14Adherens junction_Homo sapiens_hsa045201.67703697
15Leukocyte transendothelial migration_Homo sapiens_hsa046701.65276866
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.63761482
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.54927417
18Phagosome_Homo sapiens_hsa041451.53734780
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.51892075
20Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.49717663
21Mineral absorption_Homo sapiens_hsa049781.46099289
22TNF signaling pathway_Homo sapiens_hsa046681.46077472
23Salmonella infection_Homo sapiens_hsa051321.43630750
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.41274206
25Tuberculosis_Homo sapiens_hsa051521.41193473
26Toxoplasmosis_Homo sapiens_hsa051451.36784390
27Focal adhesion_Homo sapiens_hsa045101.35997835
28Protein digestion and absorption_Homo sapiens_hsa049741.35287587
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33135666
30Sphingolipid metabolism_Homo sapiens_hsa006001.25959477
31Apoptosis_Homo sapiens_hsa042101.24059743
32Amoebiasis_Homo sapiens_hsa051461.19809700
33Hematopoietic cell lineage_Homo sapiens_hsa046401.15774011
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.14493364
35TGF-beta signaling pathway_Homo sapiens_hsa043501.14374393
36Platelet activation_Homo sapiens_hsa046111.13506261
37Prion diseases_Homo sapiens_hsa050201.13376017
38Galactose metabolism_Homo sapiens_hsa000521.11409778
39Arginine biosynthesis_Homo sapiens_hsa002201.11383994
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10870399
41PPAR signaling pathway_Homo sapiens_hsa033201.09443586
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.07533633
43African trypanosomiasis_Homo sapiens_hsa051431.02598045
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01758050
45B cell receptor signaling pathway_Homo sapiens_hsa046621.00258907
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98109208
47Influenza A_Homo sapiens_hsa051640.96861222
48Fructose and mannose metabolism_Homo sapiens_hsa000510.94639275
49Collecting duct acid secretion_Homo sapiens_hsa049660.93898701
50Adipocytokine signaling pathway_Homo sapiens_hsa049200.92565014
51Tight junction_Homo sapiens_hsa045300.90658463
52Allograft rejection_Homo sapiens_hsa053300.89315380
53Graft-versus-host disease_Homo sapiens_hsa053320.87627447
54Arachidonic acid metabolism_Homo sapiens_hsa005900.87339418
55Proteoglycans in cancer_Homo sapiens_hsa052050.86773240
56Hepatitis C_Homo sapiens_hsa051600.85359963
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85216331
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85128176
59Small cell lung cancer_Homo sapiens_hsa052220.84464396
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83814336
61Viral myocarditis_Homo sapiens_hsa054160.83789501
62Shigellosis_Homo sapiens_hsa051310.83242313
63Chemokine signaling pathway_Homo sapiens_hsa040620.82159895
64Antigen processing and presentation_Homo sapiens_hsa046120.81953570
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81859984
66Histidine metabolism_Homo sapiens_hsa003400.81190204
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.80787079
68Rap1 signaling pathway_Homo sapiens_hsa040150.80194572
69Nitrogen metabolism_Homo sapiens_hsa009100.79940173
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79526241
71Ether lipid metabolism_Homo sapiens_hsa005650.79514471
72Measles_Homo sapiens_hsa051620.77941808
73Asthma_Homo sapiens_hsa053100.77531142
74HIF-1 signaling pathway_Homo sapiens_hsa040660.77125330
75Autoimmune thyroid disease_Homo sapiens_hsa053200.75668393
76Prostate cancer_Homo sapiens_hsa052150.73118559
77Bile secretion_Homo sapiens_hsa049760.72315479
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.71803481
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71153784
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71112190
81Inositol phosphate metabolism_Homo sapiens_hsa005620.70597708
82Renin-angiotensin system_Homo sapiens_hsa046140.70456324
83Vibrio cholerae infection_Homo sapiens_hsa051100.70385981
84Insulin resistance_Homo sapiens_hsa049310.70143031
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68299124
86Bladder cancer_Homo sapiens_hsa052190.68037990
87Pancreatic cancer_Homo sapiens_hsa052120.67638437
88Acute myeloid leukemia_Homo sapiens_hsa052210.66180843
89Phototransduction_Homo sapiens_hsa047440.66104193
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65596207
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65453451
92* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64668937
93Endocytosis_Homo sapiens_hsa041440.63352529
94Chronic myeloid leukemia_Homo sapiens_hsa052200.63311822
95Complement and coagulation cascades_Homo sapiens_hsa046100.62487786
96Pentose phosphate pathway_Homo sapiens_hsa000300.61456585
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.61254339
98GnRH signaling pathway_Homo sapiens_hsa049120.60123613
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60009650
100Hepatitis B_Homo sapiens_hsa051610.59779496
101* Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59047404
102ABC transporters_Homo sapiens_hsa020100.58892069
103Hippo signaling pathway_Homo sapiens_hsa043900.58506714
104Notch signaling pathway_Homo sapiens_hsa043300.58497202
105Circadian rhythm_Homo sapiens_hsa047100.57680998
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56516050
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56158233
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54573547
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53909921
110Ovarian steroidogenesis_Homo sapiens_hsa049130.52408972
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52054776
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51345326
113Pathways in cancer_Homo sapiens_hsa052000.50085590
114Ras signaling pathway_Homo sapiens_hsa040140.50014088
115* FoxO signaling pathway_Homo sapiens_hsa040680.48970674
116Renal cell carcinoma_Homo sapiens_hsa052110.47994097
117Fat digestion and absorption_Homo sapiens_hsa049750.47170631
118mTOR signaling pathway_Homo sapiens_hsa041500.46770935
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.44517410
120Prolactin signaling pathway_Homo sapiens_hsa049170.44429821
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.43951953
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43682397
123MicroRNAs in cancer_Homo sapiens_hsa052060.40420645
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.40315928
125Choline metabolism in cancer_Homo sapiens_hsa052310.40260000
126Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40057713
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38574935
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.38573808
129Pancreatic secretion_Homo sapiens_hsa049720.37129734
130Dorso-ventral axis formation_Homo sapiens_hsa043200.37050140
131Dilated cardiomyopathy_Homo sapiens_hsa054140.36392633

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