SGK223

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adherens junction assembly (GO:0034333)4.10715317
2semaphorin-plexin signaling pathway (GO:0071526)4.04566646
3planar cell polarity pathway involved in neural tube closure (GO:0090179)4.00072119
4cell-substrate adherens junction assembly (GO:0007045)3.98546311
5focal adhesion assembly (GO:0048041)3.98546311
6activation of Rac GTPase activity (GO:0032863)3.80911627
7cytoskeletal anchoring at plasma membrane (GO:0007016)3.76428822
8cell-substrate junction assembly (GO:0007044)3.68585413
9regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.63831910
10protein localization to endosome (GO:0036010)3.50907948
11apoptotic process involved in morphogenesis (GO:0060561)3.40538519
12regulation of cholesterol homeostasis (GO:2000188)3.37999542
13hemidesmosome assembly (GO:0031581)3.32723457
14stress fiber assembly (GO:0043149)3.27151331
15regulation of early endosome to late endosome transport (GO:2000641)3.25673787
16mannose metabolic process (GO:0006013)3.22791283
17skin morphogenesis (GO:0043589)3.21733229
18basement membrane organization (GO:0071711)3.15738593
19embryonic process involved in female pregnancy (GO:0060136)3.08879349
20dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.08383150
21epithelial cell-cell adhesion (GO:0090136)3.08063881
22cell-cell junction maintenance (GO:0045217)3.07895305
23atrioventricular valve morphogenesis (GO:0003181)3.06506967
24regulation of extracellular matrix disassembly (GO:0010715)3.05787464
25regulation of mammary gland epithelial cell proliferation (GO:0033599)3.04465154
26paraxial mesoderm development (GO:0048339)2.96726017
27cellular response to epidermal growth factor stimulus (GO:0071364)2.93263736
28negative regulation of fatty acid transport (GO:2000192)2.92798577
29pinocytosis (GO:0006907)2.91373930
30regulation of extracellular matrix organization (GO:1903053)2.80987051
31activation of MAPKKK activity (GO:0000185)2.80269106
32branching involved in mammary gland duct morphogenesis (GO:0060444)2.80161540
33regulation of glucose import in response to insulin stimulus (GO:2001273)2.80045378
34heterochromatin organization (GO:0070828)2.79951430
35barbed-end actin filament capping (GO:0051016)2.79197110
36response to laminar fluid shear stress (GO:0034616)2.74423894
37low-density lipoprotein particle clearance (GO:0034383)2.73980070
38COPI coating of Golgi vesicle (GO:0048205)2.72552252
39Golgi transport vesicle coating (GO:0048200)2.72552252
40regulation of NFAT protein import into nucleus (GO:0051532)2.72280781
41convergent extension (GO:0060026)2.68330690
42branching involved in salivary gland morphogenesis (GO:0060445)2.67837858
43maternal placenta development (GO:0001893)2.66787201
44proline biosynthetic process (GO:0006561)2.62401907
45protein retention in ER lumen (GO:0006621)2.61795146
46maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.61351468
47ear development (GO:0043583)2.58011542
48actin filament bundle organization (GO:0061572)2.56380753
49actin filament bundle assembly (GO:0051017)2.56380753
50modulation by virus of host morphology or physiology (GO:0019048)2.55563666
51modulation by symbiont of host cellular process (GO:0044068)2.54814656
52insulin-like growth factor receptor signaling pathway (GO:0048009)2.53307258
53positive regulation of extracellular matrix organization (GO:1903055)2.50117382
54neural tube development (GO:0021915)2.49083094
55negative regulation of chondrocyte differentiation (GO:0032331)2.47403365
56sodium ion export (GO:0071436)2.46054445
57receptor catabolic process (GO:0032801)2.45880738
58Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.44516066
59blood vessel endothelial cell migration (GO:0043534)2.43218879
60G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.43145447
61intracellular estrogen receptor signaling pathway (GO:0030520)2.42511387
62endothelial cell morphogenesis (GO:0001886)2.42488985
63retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.41596326
64layer formation in cerebral cortex (GO:0021819)2.40779696
65positive regulation of Cdc42 GTPase activity (GO:0043089)2.40590950
66regulation of apoptotic cell clearance (GO:2000425)2.40090690
67notochord development (GO:0030903)2.39772872
68glucocorticoid receptor signaling pathway (GO:0042921)2.39603630
69endodermal cell differentiation (GO:0035987)2.38996611
70regulation of ARF protein signal transduction (GO:0032012)2.37699579
71endocytic recycling (GO:0032456)2.36889467
72intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.35581728
73adherens junction organization (GO:0034332)2.34604182
74histone H3-K36 demethylation (GO:0070544)2.33477178
75cellular response to virus (GO:0098586)2.32501666
76positive regulation of endothelial cell apoptotic process (GO:2000353)2.32357588
77signal complex assembly (GO:0007172)2.30730446
78response to epidermal growth factor (GO:0070849)2.30607151
79peptidyl-tyrosine autophosphorylation (GO:0038083)2.29568900
80regulation of establishment of planar polarity (GO:0090175)2.29220116
81negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.29153676
82chondrocyte proliferation (GO:0035988)2.28392346
83amino acid import (GO:0043090)2.28067430
84apoptotic cell clearance (GO:0043277)2.27263357
85desmosome organization (GO:0002934)2.25875272
86endothelial cell chemotaxis (GO:0035767)2.25715246
87G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.25604171
88positive regulation of synapse maturation (GO:0090129)2.24289365
89negative regulation of cell fate specification (GO:0009996)2.23835487
90modulation by virus of host process (GO:0019054)2.23285976
91establishment of apical/basal cell polarity (GO:0035089)2.23057338
92vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.22874481
93regulation of apoptotic process involved in morphogenesis (GO:1902337)2.22503399
94glucose 6-phosphate metabolic process (GO:0051156)2.20747255
95regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.19646958
96glomerular visceral epithelial cell development (GO:0072015)2.19508744
97negative regulation of viral release from host cell (GO:1902187)2.17737218
98epithelial cell differentiation involved in prostate gland development (GO:0060742)2.16939245
99activation of JUN kinase activity (GO:0007257)2.16224254
100regulation of monocyte differentiation (GO:0045655)2.16043355

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.54876753
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.08087908
3MYC_22102868_ChIP-Seq_BL_Human2.86940664
4LXR_22292898_ChIP-Seq_THP-1_Human2.70927479
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.70917439
6* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.70512419
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.53359845
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.52641576
9ELK3_25401928_ChIP-Seq_HUVEC_Human2.47016441
10ZFP281_18757296_ChIP-ChIP_E14_Mouse2.30218249
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.26545827
12* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.24982379
13VDR_21846776_ChIP-Seq_THP-1_Human2.19311527
14TCF7_22412390_ChIP-Seq_EML_Mouse2.19309371
15* KDM2B_26808549_Chip-Seq_K562_Human2.18821365
16RACK7_27058665_Chip-Seq_MCF-7_Human2.14640058
17WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.04825770
18KDM2B_26808549_Chip-Seq_DND41_Human2.03934149
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.99642281
20CLOCK_20551151_ChIP-Seq_293T_Human1.98182669
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.96094285
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.92994243
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.91755066
24ZNF263_19887448_ChIP-Seq_K562_Human1.91463146
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85644590
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77983578
27ZFP281_27345836_Chip-Seq_ESCs_Mouse1.75650385
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.69201780
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.66064395
30KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.64415672
31RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.63660458
32UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.62768281
33KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.59708647
34SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.59705114
35P300_27058665_Chip-Seq_ZR-75-30cells_Human1.57534325
36EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.56840124
37KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.54591921
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53138808
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.52231664
40KDM2B_26808549_Chip-Seq_JURKAT_Human1.50025693
41TP53_22127205_ChIP-Seq_IMR90_Human1.45728511
42EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.42613124
43KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38555735
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.33557367
45TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30559304
46SMC4_20622854_ChIP-Seq_HELA_Human1.29186096
47NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.28542916
48VDR_24763502_ChIP-Seq_THP-1_Human1.25276216
49CREB1_26743006_Chip-Seq_LNCaP_Human1.23385098
50DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.21999693
51SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21888512
52NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21847739
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21402737
54CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21386445
55* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.21303202
56TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20548930
57P68_20966046_ChIP-Seq_HELA_Human1.20418772
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.19876695
59TRIM28_21343339_ChIP-Seq_HEK293_Human1.19760632
60DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19604036
61DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19205871
62SA1_27219007_Chip-Seq_ERYTHROID_Human1.19152046
63ATF3_27146783_Chip-Seq_COLON_Human1.17816407
64* RUNX1_27514584_Chip-Seq_MCF-7_Human1.17217569
65MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16281009
66ESR1_21235772_ChIP-Seq_MCF-7_Human1.15369871
67NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12177471
68ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.12156833
69MAF_26560356_Chip-Seq_TH1_Human1.11654233
70SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.11592855
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11586203
72* UBF1/2_26484160_Chip-Seq_HMECs_Human1.10796187
73PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10532442
74SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10012217
75SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07810054
76SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07236681
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04998931
78CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03159739
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02937825
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02120166
81RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00936915
82CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00365997
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99648697
84UTX_26944678_Chip-Seq_JUKART_Human0.99484521
85SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99364070
86BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99120595
87CTCF_27219007_Chip-Seq_Bcells_Human0.99074858
88SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97350471
89HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97200334
90GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96691195
91TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95200475
92SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94346467
93SMC1_22415368_ChIP-Seq_MEFs_Mouse0.94014878
94NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.92211778
95P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91785454
96PPARA_22158963_ChIP-Seq_LIVER_Mouse0.91153037
97TET1_21490601_ChIP-Seq_MESCs_Mouse0.90032307
98KAP1_27257070_Chip-Seq_ESCs_Mouse0.89463946
99OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88636900
100NCOR1_26117541_ChIP-Seq_K562_Human0.88304736

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.83986242
2MP0003566_abnormal_cell_adhesion3.41868223
3MP0005257_abnormal_intraocular_pressure3.34589414
4MP0001849_ear_inflammation3.30628770
5MP0005076_abnormal_cell_differentiation2.69950743
6MP0004858_abnormal_nervous_system2.47545640
7MP0002254_reproductive_system_inflammat2.40467227
8MP0004272_abnormal_basement_membrane2.39862123
9MP0008438_abnormal_cutaneous_collagen2.29814476
10MP0003091_abnormal_cell_migration2.28760606
11MP0002089_abnormal_postnatal_growth/wei2.26236907
12MP0000566_synostosis2.16697856
13MP0000537_abnormal_urethra_morphology2.16564594
14MP0010234_abnormal_vibrissa_follicle2.12120826
15MP0001348_abnormal_lacrimal_gland2.12056187
16MP0005409_darkened_coat_color2.07677341
17MP0003453_abnormal_keratinocyte_physiol2.04469571
18MP0004264_abnormal_extraembryonic_tissu1.82934259
19MP0009384_cardiac_valve_regurgitation1.78000068
20MP0003279_aneurysm1.76811854
21MP0010030_abnormal_orbit_morphology1.73037246
22MP0003172_abnormal_lysosome_physiology1.70856958
23MP0003941_abnormal_skin_development1.69575380
24MP0005058_abnormal_lysosome_morphology1.69275102
25MP0004185_abnormal_adipocyte_glucose1.66967140
26MP0005451_abnormal_body_composition1.58996704
27MP0005623_abnormal_meninges_morphology1.57064744
28MP0003283_abnormal_digestive_organ1.54231580
29MP0002796_impaired_skin_barrier1.51628265
30MP0004859_abnormal_synaptic_plasticity1.49070026
31MP0000767_abnormal_smooth_muscle1.47895122
32MP0003300_gastrointestinal_ulcer1.47258962
33MP0009672_abnormal_birth_weight1.45534091
34MP0008260_abnormal_autophagy1.40588208
35MP0009840_abnormal_foam_cell1.40354050
36MP0001915_intracranial_hemorrhage1.37376876
37MP0001958_emphysema1.36791204
38MP0003329_amyloid_beta_deposits1.36288662
39MP0003123_paternal_imprinting1.35546290
40MP0005023_abnormal_wound_healing1.33549671
41MP0000858_altered_metastatic_potential1.31494538
42MP0000003_abnormal_adipose_tissue1.30303677
43MP0005501_abnormal_skin_physiology1.22749610
44MP0010352_gastrointestinal_tract_polyps1.18918934
45MP0000534_abnormal_ureter_morphology1.18656749
46MP0000579_abnormal_nail_morphology1.16987418
47MP0005666_abnormal_adipose_tissue1.16577768
48MP0002877_abnormal_melanocyte_morpholog1.16187524
49MP0010368_abnormal_lymphatic_system1.16087685
50MP0005375_adipose_tissue_phenotype1.15550705
51MP0000762_abnormal_tongue_morphology1.13992024
52MP0000428_abnormal_craniofacial_morphol1.09843335
53MP0003385_abnormal_body_wall1.09285655
54MP0004947_skin_inflammation1.08455928
55MP0009053_abnormal_anal_canal1.08148194
56MP0000751_myopathy1.06748189
57MP0003942_abnormal_urinary_system1.06020551
58MP0000490_abnormal_crypts_of1.05439505
59MP0005360_urolithiasis1.04098492
60MP0001730_embryonic_growth_arrest1.03478739
61MP0006138_congestive_heart_failure1.02399727
62MP0003115_abnormal_respiratory_system1.00770433
63MP0002249_abnormal_larynx_morphology1.00529561
64MP0000733_abnormal_muscle_development1.00256512
65MP0002998_abnormal_bone_remodeling0.95268866
66MP0003303_peritoneal_inflammation0.94526208
67MP0002896_abnormal_bone_mineralization0.93768522
68MP0000678_abnormal_parathyroid_gland0.93037286
69MP0005621_abnormal_cell_physiology0.92716570
70MP0002925_abnormal_cardiovascular_devel0.87383806
71MP0002092_abnormal_eye_morphology0.86502228
72MP0002697_abnormal_eye_size0.86234238
73MP0003634_abnormal_glial_cell0.85758414
74MP0004270_analgesia0.85473524
75MP0010630_abnormal_cardiac_muscle0.85390217
76MP0003122_maternal_imprinting0.84960531
77MP0000432_abnormal_head_morphology0.82841531
78MP0002060_abnormal_skin_morphology0.82715726
79MP0002086_abnormal_extraembryonic_tissu0.82327103
80MP0001614_abnormal_blood_vessel0.80011880
81MP0003436_decreased_susceptibility_to0.79778729
82MP0003984_embryonic_growth_retardation0.78240377
83MP0002116_abnormal_craniofacial_bone0.75387356
84MP0003183_abnormal_peptide_metabolism0.75174298
85MP0003191_abnormal_cellular_cholesterol0.73561382
86MP0001340_abnormal_eyelid_morphology0.73519714
87MP0009278_abnormal_bone_marrow0.72770735
88MP0001672_abnormal_embryogenesis/_devel0.72299294
89MP0005380_embryogenesis_phenotype0.72299294
90MP0005508_abnormal_skeleton_morphology0.72256381
91MP0000477_abnormal_intestine_morphology0.72145190
92MP0002088_abnormal_embryonic_growth/wei0.71138577
93MP0001299_abnormal_eye_distance/0.70834066
94MP0002111_abnormal_tail_morphology0.70693553
95MP0002085_abnormal_embryonic_tissue0.70198843
96MP0004381_abnormal_hair_follicle0.68023384
97MP0002932_abnormal_joint_morphology0.65459923
98MP0005670_abnormal_white_adipose0.64913655
99MP0008569_lethality_at_weaning0.64585136
100MP0003861_abnormal_nervous_system0.64525635

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)3.53619332
2Hyperacusis (HP:0010780)3.53243870
3Protrusio acetabuli (HP:0003179)3.51255805
4Shallow orbits (HP:0000586)3.35234278
5Bronchomalacia (HP:0002780)3.30600049
6Broad face (HP:0000283)3.13249875
7Cerebral aneurysm (HP:0004944)2.91875883
8Obstructive sleep apnea (HP:0002870)2.77160257
9Long palpebral fissure (HP:0000637)2.60971690
10Flat acetabular roof (HP:0003180)2.55946722
11Distal lower limb amyotrophy (HP:0008944)2.52100541
12Ulnar bowing (HP:0003031)2.51174909
13Atrophic scars (HP:0001075)2.47762757
14Arterial tortuosity (HP:0005116)2.45899136
15Hemorrhage of the eye (HP:0011885)2.44297253
16Neonatal short-limb short stature (HP:0008921)2.43176325
17Disproportionate tall stature (HP:0001519)2.42023396
18Deep venous thrombosis (HP:0002625)2.41471970
19Arnold-Chiari malformation (HP:0002308)2.38307628
20Upper limb amyotrophy (HP:0009129)2.37412472
21Distal upper limb amyotrophy (HP:0007149)2.37412472
22Achilles tendon contracture (HP:0001771)2.28749592
23Turricephaly (HP:0000262)2.28623567
24Renal duplication (HP:0000075)2.28529268
25Fragile skin (HP:0001030)2.26724324
26Insomnia (HP:0100785)2.19695554
27Vascular tortuosity (HP:0004948)2.18603435
28Lower limb amyotrophy (HP:0007210)2.16038092
29Trigonocephaly (HP:0000243)2.15168934
30Mitral valve prolapse (HP:0001634)2.13355075
31Abnormality of the Achilles tendon (HP:0005109)2.12983404
32Bladder diverticulum (HP:0000015)2.10782402
33Mitral regurgitation (HP:0001653)2.07040937
34Increased connective tissue (HP:0009025)2.06434898
35Broad metatarsal (HP:0001783)2.05847001
36Abnormality of the distal phalanx of the thumb (HP:0009617)2.04766022
37Small epiphyses (HP:0010585)1.96034818
38Genu recurvatum (HP:0002816)1.95515711
39Aplasia involving bones of the extremities (HP:0009825)1.94797438
40Aplasia involving bones of the upper limbs (HP:0009823)1.94797438
41Aplasia of the phalanges of the hand (HP:0009802)1.94797438
42Blue sclerae (HP:0000592)1.93383944
43Pointed chin (HP:0000307)1.92235319
44Selective tooth agenesis (HP:0001592)1.92203907
45Vertebral arch anomaly (HP:0008438)1.91720643
46Abnormal ossification of hand bones (HP:0005921)1.90400958
47Overriding aorta (HP:0002623)1.90176371
48Cervical subluxation (HP:0003308)1.89205559
49Cellulitis (HP:0100658)1.87492068
50Advanced eruption of teeth (HP:0006288)1.86719594
51Spinal rigidity (HP:0003306)1.86411960
52Thin ribs (HP:0000883)1.85619862
53Abnormal vertebral ossification (HP:0100569)1.84375206
54Premature skin wrinkling (HP:0100678)1.84127756
55Thin bony cortex (HP:0002753)1.83154738
56Elfin facies (HP:0004428)1.82823511
57Aortic dissection (HP:0002647)1.82820363
58Asymmetry of the thorax (HP:0001555)1.82370230
59Camptodactyly of toe (HP:0001836)1.81459964
60Biconcave vertebral bodies (HP:0004586)1.80394090
61Natal tooth (HP:0000695)1.79948413
62Ankle contracture (HP:0006466)1.79715220
63Difficulty climbing stairs (HP:0003551)1.79038226
64Aneurysm (HP:0002617)1.78422877
65Cerebral inclusion bodies (HP:0100314)1.73818192
66Stridor (HP:0010307)1.72689060
67Dilatation of the ascending aorta (HP:0005111)1.71517310
68Broad thumb (HP:0011304)1.70381352
69Wormian bones (HP:0002645)1.70138544
70Abnormality of the thoracic spine (HP:0100711)1.68771580
71Partial duplication of thumb phalanx (HP:0009944)1.68552275
72Distal lower limb muscle weakness (HP:0009053)1.68417094
73Neurofibrillary tangles (HP:0002185)1.68067041
74Segmental peripheral demyelination/remyelination (HP:0003481)1.65738884
75Choanal stenosis (HP:0000452)1.65343768
76Abnormality of carpal bone ossification (HP:0006257)1.65212811
77Vertebral compression fractures (HP:0002953)1.64928018
78Emphysema (HP:0002097)1.64926541
79Neonatal death (HP:0003811)1.64146256
80Polygenic inheritance (HP:0010982)1.63795728
81Mildly elevated creatine phosphokinase (HP:0008180)1.63712117
82Epiphyseal dysplasia (HP:0002656)1.63677153
83Gastrointestinal stroma tumor (HP:0100723)1.63474919
84Axonal loss (HP:0003447)1.63267574
85Dislocated radial head (HP:0003083)1.62865549
86Supernumerary nipples (HP:0002558)1.62052941
87Skull defect (HP:0001362)1.62039591
88Increased variability in muscle fiber diameter (HP:0003557)1.61117958
89Aortic aneurysm (HP:0004942)1.61023462
90Hand muscle atrophy (HP:0009130)1.60987916
91Joint laxity (HP:0001388)1.59415328
92Midface retrusion (HP:0011800)1.58936794
93Esophageal varix (HP:0002040)1.57840136
94Renovascular hypertension (HP:0100817)1.57085856
95Annular pancreas (HP:0001734)1.56351160
96Hypercholesterolemia (HP:0003124)1.56287212
97Centrally nucleated skeletal muscle fibers (HP:0003687)1.56220106
98Abnormality of dentin (HP:0010299)1.55148785
99Flexion contracture of toe (HP:0005830)1.55033531
100Joint contractures involving the joints of the feet (HP:0100492)1.55033531

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.98263470
2SIK13.43358581
3SMG13.23037859
4MAP3K103.12321370
5ERN13.09424798
6EPHA23.00345331
7PRPF4B2.95046009
8RIPK12.89001765
9CDK122.71873268
10EEF2K2.65164553
11ICK2.63616059
12FGFR42.53793481
13MAP3K92.05797865
14PDGFRA2.04338436
15TTN1.93098801
16LATS21.69571343
17MST1R1.60773892
18SIK21.57167433
19MAP3K131.55595214
20TYRO31.47638578
21MAP4K11.45754560
22NTRK11.32812234
23PTK21.32271483
24CDC42BPA1.31170608
25EPHB21.26893369
26PAK41.26009042
27MARK21.25421042
28PTK61.19635566
29PKN21.16396460
30MTOR1.12123785
31TAOK21.09950238
32RPS6KA21.09055153
33ARAF1.06314048
34BMX1.02592274
35TESK10.96248274
36PRKD20.94867148
37DYRK1B0.93654841
38DDR20.93442250
39MET0.90209824
40FGFR30.86169493
41KSR20.85769691
42TAOK10.85064460
43EPHB10.82294341
44CAMK1D0.80143014
45IRAK30.78124710
46PDPK10.74785121
47PRKG20.72293400
48CSF1R0.71223361
49PAK20.70111456
50MAP3K80.68475536
51LMTK20.66894462
52RPS6KC10.64272411
53RPS6KL10.64272411
54RIPK40.63355211
55FGFR10.62354528
56MAP3K10.61235146
57PRKD30.59285929
58CDK40.58940215
59MAP3K70.58873293
60DMPK0.57938927
61BRD40.57746503
62PDGFRB0.57592997
63HIPK20.55563798
64MELK0.52421311
65MAP3K110.52259856
66NTRK20.51220177
67MAP2K20.50822605
68MAPK110.50797520
69CHUK0.50356237
70RET0.49472396
71CAMKK10.47212138
72PIM20.46986873
73NEK90.45433174
74TESK20.45321701
75CAMK1G0.44892067
76MAPK150.43664402
77MAP2K30.43460656
78SGK30.43455521
79SIK30.43238422
80PDK10.41792664
81MAP3K30.41745835
82CDK60.41688213
83CDK90.41682715
84RPS6KA10.41433414
85ERBB40.40917824
86CDK70.39860317
87FGFR20.39799069
88ROCK20.39182331
89MAP3K140.38424334
90LATS10.38407191
91RPS6KA60.37726884
92BRAF0.36250283
93MAPK70.35533359
94FGR0.32903158
95WNK10.32181467
96PRKCH0.31126173
97STK380.30351832
98MAPK100.30348724
99NME20.30259417
100MAPKAPK20.29349475

Predicted pathways (KEGG)

RankGene SetZ-score
1Notch signaling pathway_Homo sapiens_hsa043302.12864461
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.99842242
3Chronic myeloid leukemia_Homo sapiens_hsa052201.84020193
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.77208390
5Adherens junction_Homo sapiens_hsa045201.74432059
6Central carbon metabolism in cancer_Homo sapiens_hsa052301.74144379
7Other glycan degradation_Homo sapiens_hsa005111.63680579
8B cell receptor signaling pathway_Homo sapiens_hsa046621.60728730
9Endometrial cancer_Homo sapiens_hsa052131.57686876
10Focal adhesion_Homo sapiens_hsa045101.57046582
11Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.53119977
12Acute myeloid leukemia_Homo sapiens_hsa052211.49548935
13Thyroid cancer_Homo sapiens_hsa052161.49391787
14Bladder cancer_Homo sapiens_hsa052191.48699350
15ECM-receptor interaction_Homo sapiens_hsa045121.47337692
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.42137744
17Thyroid hormone signaling pathway_Homo sapiens_hsa049191.42031318
18Non-small cell lung cancer_Homo sapiens_hsa052231.39246236
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.34842831
20Proteoglycans in cancer_Homo sapiens_hsa052051.31102444
21ErbB signaling pathway_Homo sapiens_hsa040121.27421737
22Neurotrophin signaling pathway_Homo sapiens_hsa047221.26935482
23VEGF signaling pathway_Homo sapiens_hsa043701.26776657
24MicroRNAs in cancer_Homo sapiens_hsa052061.26571958
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25989198
26Renal cell carcinoma_Homo sapiens_hsa052111.25819399
27Small cell lung cancer_Homo sapiens_hsa052221.25412955
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.25153753
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.19302525
30Prion diseases_Homo sapiens_hsa050201.19266643
31Basal cell carcinoma_Homo sapiens_hsa052171.19156565
32Colorectal cancer_Homo sapiens_hsa052101.16153405
33Axon guidance_Homo sapiens_hsa043601.15910092
34Pancreatic cancer_Homo sapiens_hsa052121.14124930
35Glioma_Homo sapiens_hsa052141.13668829
36Prostate cancer_Homo sapiens_hsa052151.08648359
37Galactose metabolism_Homo sapiens_hsa000521.06304165
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05964027
39Hippo signaling pathway_Homo sapiens_hsa043901.03678915
40Fructose and mannose metabolism_Homo sapiens_hsa000511.03313987
41Insulin signaling pathway_Homo sapiens_hsa049101.00806644
42Regulation of actin cytoskeleton_Homo sapiens_hsa048101.00722384
43Estrogen signaling pathway_Homo sapiens_hsa049150.98757765
44Phospholipase D signaling pathway_Homo sapiens_hsa040720.98174828
45GnRH signaling pathway_Homo sapiens_hsa049120.96962640
46Rap1 signaling pathway_Homo sapiens_hsa040150.93981930
47Thyroid hormone synthesis_Homo sapiens_hsa049180.90070105
48Melanogenesis_Homo sapiens_hsa049160.88199558
49Apoptosis_Homo sapiens_hsa042100.87921801
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87909982
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87462069
52Amoebiasis_Homo sapiens_hsa051460.87115387
53Long-term potentiation_Homo sapiens_hsa047200.86464995
54Toxoplasmosis_Homo sapiens_hsa051450.84783822
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84534486
56Hepatitis B_Homo sapiens_hsa051610.84142506
57Protein digestion and absorption_Homo sapiens_hsa049740.83976725
58Choline metabolism in cancer_Homo sapiens_hsa052310.82761273
59Tight junction_Homo sapiens_hsa045300.81981996
60Wnt signaling pathway_Homo sapiens_hsa043100.81000550
61Viral myocarditis_Homo sapiens_hsa054160.80470999
62AMPK signaling pathway_Homo sapiens_hsa041520.80004056
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79254462
64Pentose phosphate pathway_Homo sapiens_hsa000300.76878471
65HTLV-I infection_Homo sapiens_hsa051660.76741662
66Hepatitis C_Homo sapiens_hsa051600.74782508
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74666349
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74062775
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.74021231
70Endocytosis_Homo sapiens_hsa041440.73811640
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73708587
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73520837
73Inositol phosphate metabolism_Homo sapiens_hsa005620.72485906
74Prolactin signaling pathway_Homo sapiens_hsa049170.72209482
75Pathways in cancer_Homo sapiens_hsa052000.70214149
76Osteoclast differentiation_Homo sapiens_hsa043800.69802457
77Biosynthesis of amino acids_Homo sapiens_hsa012300.68689058
78Viral carcinogenesis_Homo sapiens_hsa052030.68394610
79Insulin resistance_Homo sapiens_hsa049310.67733020
80Lysine degradation_Homo sapiens_hsa003100.67088398
81T cell receptor signaling pathway_Homo sapiens_hsa046600.65848402
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64796383
83MAPK signaling pathway_Homo sapiens_hsa040100.64739303
84Shigellosis_Homo sapiens_hsa051310.64354712
85mTOR signaling pathway_Homo sapiens_hsa041500.64147061
86Influenza A_Homo sapiens_hsa051640.63148764
87HIF-1 signaling pathway_Homo sapiens_hsa040660.61727210
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.61353739
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.59707267
90Leishmaniasis_Homo sapiens_hsa051400.59353708
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.59145839
92TNF signaling pathway_Homo sapiens_hsa046680.58853697
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57443013
94Fatty acid biosynthesis_Homo sapiens_hsa000610.57395557
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54125250
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51907956
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51644634
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51355035
99Gap junction_Homo sapiens_hsa045400.51310353
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50159113

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