ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.51550711
2	cellular response to ATP (GO:0071318)	4.36582838
3	water-soluble vitamin biosynthetic process (GO:0042364)	4.28483023
4	gamma-aminobutyric acid transport (GO:0015812)	4.22249873
5	sulfation (GO:0051923)	4.15832109
6	DNA deamination (GO:0045006)	3.83602896
7	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.76991215
8	tryptophan catabolic process (GO:0006569)	3.75844142
9	indole-containing compound catabolic process (GO:0042436)	3.75844142
10	indolalkylamine catabolic process (GO:0046218)	3.75844142
11	indolalkylamine metabolic process (GO:0006586)	3.70855709
12	cell proliferation in forebrain (GO:0021846)	3.69704850
13	L-fucose catabolic process (GO:0042355)	3.63952497
14	fucose catabolic process (GO:0019317)	3.63952497
15	L-fucose metabolic process (GO:0042354)	3.63952497
16	kynurenine metabolic process (GO:0070189)	3.63680364
17	protein polyglutamylation (GO:0018095)	3.39852273
18	kidney morphogenesis (GO:0060993)	3.29922531
19	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.26767437
20	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.26767437
21	NADH dehydrogenase complex assembly (GO:0010257)	3.26767437
22	somite development (GO:0061053)	3.24874282
23	tryptophan metabolic process (GO:0006568)	3.22404151
24	negative regulation of telomere maintenance (GO:0032205)	3.18295632
25	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.16494060
26	transmission of nerve impulse (GO:0019226)	3.15859816
27	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.13192978
28	protein complex biogenesis (GO:0070271)	3.13008605
29	neuronal action potential (GO:0019228)	3.08849849
30	indole-containing compound metabolic process (GO:0042430)	3.06195134
31	reflex (GO:0060004)	2.94414350
32	detection of light stimulus involved in visual perception (GO:0050908)	2.91591121
33	detection of light stimulus involved in sensory perception (GO:0050962)	2.91591121
34	preassembly of GPI anchor in ER membrane (GO:0016254)	2.91361309
35	membrane depolarization during action potential (GO:0086010)	2.90134903
36	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.88981217
37	mitochondrial respiratory chain complex assembly (GO:0033108)	2.88808635
38	negative regulation of mast cell activation (GO:0033004)	2.87161901
39	pyrimidine nucleobase catabolic process (GO:0006208)	2.86814809
40	piRNA metabolic process (GO:0034587)	2.86566634
41	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.84517954
42	primary amino compound metabolic process (GO:1901160)	2.81009478
43	positive regulation of fatty acid transport (GO:2000193)	2.79314311
44	response to pheromone (GO:0019236)	2.78370606
45	DNA methylation involved in gamete generation (GO:0043046)	2.76153321
46	protein-cofactor linkage (GO:0018065)	2.75712399
47	regulation of neurotransmitter uptake (GO:0051580)	2.75503028
48	axoneme assembly (GO:0035082)	2.73316792
49	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.72929248
50	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.72929248
51	regulation of collateral sprouting (GO:0048670)	2.71802815
52	neural tube formation (GO:0001841)	2.70940089
53	serotonin metabolic process (GO:0042428)	2.70602525
54	negative regulation of appetite (GO:0032099)	2.70497923
55	negative regulation of response to food (GO:0032096)	2.70497923
56	synapsis (GO:0007129)	2.69800327
57	spinal cord motor neuron differentiation (GO:0021522)	2.69632768
58	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.69560597
59	nonmotile primary cilium assembly (GO:0035058)	2.68892144
60	regulation of action potential (GO:0098900)	2.67352827
61	negative regulation of systemic arterial blood pressure (GO:0003085)	2.65798466
62	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.61827223
63	GPI anchor metabolic process (GO:0006505)	2.61677995
64	adaptation of signaling pathway (GO:0023058)	2.61405257
65	synaptic transmission, cholinergic (GO:0007271)	2.59461072
66	cornea development in camera-type eye (GO:0061303)	2.58241137
67	retinal cone cell development (GO:0046549)	2.56511559
68	cellular biogenic amine catabolic process (GO:0042402)	2.56121425
69	amine catabolic process (GO:0009310)	2.56121425
70	recombinational repair (GO:0000725)	2.54993370
71	double-strand break repair via homologous recombination (GO:0000724)	2.53872675
72	dentate gyrus development (GO:0021542)	2.52526006
73	regulation of posttranscriptional gene silencing (GO:0060147)	2.52140519
74	regulation of gene silencing by miRNA (GO:0060964)	2.52140519
75	regulation of gene silencing by RNA (GO:0060966)	2.52140519
76	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.50537196
77	photoreceptor cell development (GO:0042461)	2.50351042
78	regulation of hippo signaling (GO:0035330)	2.50028860
79	regulation of DNA endoreduplication (GO:0032875)	2.49847103
80	respiratory chain complex IV assembly (GO:0008535)	2.48620638
81	regulation of glomerulus development (GO:0090192)	2.48396324
82	male meiosis I (GO:0007141)	2.47033748
83	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	2.45232487
84	regulation of mesoderm development (GO:2000380)	2.44794442
85	neuromuscular synaptic transmission (GO:0007274)	2.43714089
86	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.43545209
87	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.42762195
88	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.42059009
89	reciprocal meiotic recombination (GO:0007131)	2.40749176
90	reciprocal DNA recombination (GO:0035825)	2.40749176
91	rRNA catabolic process (GO:0016075)	2.40220918
92	epithelial cilium movement (GO:0003351)	2.40164121
93	action potential (GO:0001508)	2.39911747
94	replication fork processing (GO:0031297)	2.39186490
95	cAMP catabolic process (GO:0006198)	2.38658511
96	cerebellar Purkinje cell differentiation (GO:0021702)	2.38576613
97	regulation of telomere maintenance (GO:0032204)	2.38049774
98	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.37719706
99	nucleobase catabolic process (GO:0046113)	2.37521815
100	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.37368904

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.43455282
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.60988334
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.22824149
4	VDR_22108803_ChIP-Seq_LS180_Human	3.16721630
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.79156578
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.52516003
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.52209261
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.40374350
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.14498490
10	EWS_26573619_Chip-Seq_HEK293_Human	2.08316196
11	FUS_26573619_Chip-Seq_HEK293_Human	2.07748871
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.07485348
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.05022291
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.97720096
15	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.96047591
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.92701974
17	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.91033768
18	IRF1_19129219_ChIP-ChIP_H3396_Human	1.89436081
19	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.88859964
20	REST_21632747_ChIP-Seq_MESCs_Mouse	1.86336780
21	TAF15_26573619_Chip-Seq_HEK293_Human	1.82325118
22	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.81194305
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.81144078
24	P300_19829295_ChIP-Seq_ESCs_Human	1.75139491
25	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.67993713
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.62657920
27	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.62613595
28	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.62336333
29	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.61456719
30	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.58726769
31	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.56690200
32	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.54944076
33	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.51372444
34	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.49393884
35	RNF2_27304074_Chip-Seq_NSC_Mouse	1.48750273
36	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.48106385
37	STAT3_23295773_ChIP-Seq_U87_Human	1.45465992
38	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.44249142
39	TCF4_23295773_ChIP-Seq_U87_Human	1.43644584
40	BCAT_22108803_ChIP-Seq_LS180_Human	1.42315496
41	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.41324560
42	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.41218728
43	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.41218728
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.37933991
45	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.37933991
46	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.37671270
47	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.37396216
48	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.35849122
49	TP53_22573176_ChIP-Seq_HFKS_Human	1.35671772
50	MYC_18940864_ChIP-ChIP_HL60_Human	1.35660531
51	SMAD4_21799915_ChIP-Seq_A2780_Human	1.31442353
52	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.28152384
53	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.27300734
54	AR_25329375_ChIP-Seq_VCAP_Human	1.27213001
55	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.25353934
56	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.25163905
57	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.23960096
58	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.23514981
59	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21306576
60	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.19869201
61	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.19831029
62	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.18953750
63	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.18615737
64	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.18443117
65	NCOR_22424771_ChIP-Seq_293T_Human	1.17573879
66	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.17216598
67	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.15995558
68	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.15911320
69	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.15704722
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.15354938
71	NANOG_19829295_ChIP-Seq_ESCs_Human	1.13866132
72	SOX2_19829295_ChIP-Seq_ESCs_Human	1.13866132
73	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.13601937
74	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.13601937
75	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.12896166
76	AR_21572438_ChIP-Seq_LNCaP_Human	1.12622888
77	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.11446312
78	RUNX2_22187159_ChIP-Seq_PCA_Human	1.10562667
79	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.08308598
80	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.07152541
81	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.06706612
82	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.05635263
83	DROSHA_22980978_ChIP-Seq_HELA_Human	1.03409042
84	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03170311
85	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.03094217
86	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.02794876
87	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02783909
88	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.01943838
89	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.01898992
90	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00669044
91	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.00569445
92	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.99189486
93	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.99179088
94	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.98975016
95	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.98332099
96	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.96875161
97	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.96677787
98	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.95375663
99	P53_22387025_ChIP-Seq_ESCs_Mouse	0.93873281
100	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.93626120

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	2.96340978
2	MP0003646_muscle_fatigue	2.93461439
3	MP0005646_abnormal_pituitary_gland	2.86298377
4	MP0008877_abnormal_DNA_methylation	2.63219674
5	MP0002837_dystrophic_cardiac_calcinosis	2.48550812
6	MP0001968_abnormal_touch/_nociception	2.48532068
7	MP0009046_muscle_twitch	2.36467081
8	MP0002102_abnormal_ear_morphology	2.33719122
9	MP0003787_abnormal_imprinting	2.23849301
10	MP0004885_abnormal_endolymph	2.15836393
11	MP0003195_calcinosis	2.11163762
12	MP0005551_abnormal_eye_electrophysiolog	2.09172374
13	MP0009745_abnormal_behavioral_response	2.04278014
14	MP0002272_abnormal_nervous_system	2.00459455
15	MP0000631_abnormal_neuroendocrine_gland	1.98643436
16	MP0000569_abnormal_digit_pigmentation	1.97370683
17	MP0004145_abnormal_muscle_electrophysio	1.96089400
18	MP0008872_abnormal_physiological_respon	1.95285023
19	MP0001485_abnormal_pinna_reflex	1.94416421
20	MP0002736_abnormal_nociception_after	1.88842322
21	MP0001986_abnormal_taste_sensitivity	1.87704345
22	MP0006072_abnormal_retinal_apoptosis	1.83874227
23	MP0004142_abnormal_muscle_tone	1.83066366
24	MP0003880_abnormal_central_pattern	1.73094649
25	MP0002064_seizures	1.62928053
26	MP0002653_abnormal_ependyma_morphology	1.61446331
27	MP0001486_abnormal_startle_reflex	1.59035557
28	MP0002876_abnormal_thyroid_physiology	1.58174069
29	MP0002160_abnormal_reproductive_system	1.55527670
30	MP0004133_heterotaxia	1.51805166
31	MP0003635_abnormal_synaptic_transmissio	1.50101725
32	MP0004043_abnormal_pH_regulation	1.48952231
33	MP0002734_abnormal_mechanical_nocicepti	1.48619105
34	MP0005253_abnormal_eye_physiology	1.44995229
35	MP0008995_early_reproductive_senescence	1.44474017
36	MP0002638_abnormal_pupillary_reflex	1.43621169
37	MP0002733_abnormal_thermal_nociception	1.43344126
38	MP0002735_abnormal_chemical_nociception	1.41588180
39	MP0004130_abnormal_muscle_cell	1.41058129
40	MP0002063_abnormal_learning/memory/cond	1.38888348
41	MP0002572_abnormal_emotion/affect_behav	1.36363720
42	MP0001970_abnormal_pain_threshold	1.34459061
43	MP0004147_increased_porphyrin_level	1.34004205
44	MP0006276_abnormal_autonomic_nervous	1.33904841
45	MP0005645_abnormal_hypothalamus_physiol	1.32132395
46	MP0005423_abnormal_somatic_nervous	1.31623630
47	MP0003136_yellow_coat_color	1.30423304
48	MP0000049_abnormal_middle_ear	1.29085989
49	MP0005389_reproductive_system_phenotype	1.27987309
50	MP0000372_irregular_coat_pigmentation	1.27156860
51	MP0002138_abnormal_hepatobiliary_system	1.26994005
52	MP0002557_abnormal_social/conspecific_i	1.26027162
53	MP0005174_abnormal_tail_pigmentation	1.25853004
54	MP0003011_delayed_dark_adaptation	1.19933879
55	MP0004742_abnormal_vestibular_system	1.17569856
56	MP0002938_white_spotting	1.17235182
57	MP0008875_abnormal_xenobiotic_pharmacok	1.14727484
58	MP0001501_abnormal_sleep_pattern	1.13193637
59	MP0002067_abnormal_sensory_capabilities	1.11933972
60	MP0003890_abnormal_embryonic-extraembry	1.11549499
61	MP0000778_abnormal_nervous_system	1.10656068
62	MP0001529_abnormal_vocalization	1.10296099
63	MP0005386_behavior/neurological_phenoty	1.08848655
64	MP0004924_abnormal_behavior	1.08848655
65	MP0003119_abnormal_digestive_system	1.06971134
66	MP0002184_abnormal_innervation	1.06624711
67	MP0008789_abnormal_olfactory_epithelium	1.06302552
68	MP0002163_abnormal_gland_morphology	1.05465714
69	MP0003938_abnormal_ear_development	1.02812992
70	MP0003121_genomic_imprinting	1.02109435
71	MP0001440_abnormal_grooming_behavior	1.00659438
72	MP0001963_abnormal_hearing_physiology	1.00282344
73	MP0000427_abnormal_hair_cycle	0.98982229
74	MP0000026_abnormal_inner_ear	0.98553848
75	MP0002928_abnormal_bile_duct	0.97523206
76	MP0004134_abnormal_chest_morphology	0.95013066
77	MP0002752_abnormal_somatic_nervous	0.94671854
78	MP0004859_abnormal_synaptic_plasticity	0.94155230
79	MP0001188_hyperpigmentation	0.92545869
80	MP0001984_abnormal_olfaction	0.91805091
81	MP0005195_abnormal_posterior_eye	0.90825798
82	MP0005084_abnormal_gallbladder_morpholo	0.90608844
83	MP0001905_abnormal_dopamine_level	0.90090315
84	MP0003937_abnormal_limbs/digits/tail_de	0.90024782
85	MP0002095_abnormal_skin_pigmentation	0.89420293
86	MP0004270_analgesia	0.88823581
87	MP0001919_abnormal_reproductive_system	0.88774145
88	MP0008775_abnormal_heart_ventricle	0.88343086
89	MP0005379_endocrine/exocrine_gland_phen	0.86755084
90	MP0004215_abnormal_myocardial_fiber	0.85084573
91	MP0005499_abnormal_olfactory_system	0.85009525
92	MP0005394_taste/olfaction_phenotype	0.85009525
93	MP0002751_abnormal_autonomic_nervous	0.84843641
94	MP0008058_abnormal_DNA_repair	0.81276131
95	MP0002229_neurodegeneration	0.80912901
96	MP0001293_anophthalmia	0.79992240
97	MP0003698_abnormal_male_reproductive	0.78569029
98	MP0002882_abnormal_neuron_morphology	0.78461032
99	MP0000955_abnormal_spinal_cord	0.75376396
100	MP0005410_abnormal_fertilization	0.75370974

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.29729970
2	Pancreatic fibrosis (HP:0100732)	3.91472757
3	Congenital stationary night blindness (HP:0007642)	3.67055267
4	True hermaphroditism (HP:0010459)	3.66108541
5	Nephronophthisis (HP:0000090)	3.51350776
6	Genetic anticipation (HP:0003743)	3.46876154
7	Abnormality of midbrain morphology (HP:0002418)	3.44395446
8	Molar tooth sign on MRI (HP:0002419)	3.44395446
9	Pendular nystagmus (HP:0012043)	3.44274691
10	Progressive cerebellar ataxia (HP:0002073)	3.39560161
11	Methylmalonic acidemia (HP:0002912)	3.04087976
12	Abolished electroretinogram (ERG) (HP:0000550)	2.99663144
13	Abnormality of the renal medulla (HP:0100957)	2.98638211
14	Abnormality of the renal cortex (HP:0011035)	2.86653729
15	Gaze-evoked nystagmus (HP:0000640)	2.83114360
16	Type II lissencephaly (HP:0007260)	2.79091036
17	Chronic hepatic failure (HP:0100626)	2.71194471
18	Cystic liver disease (HP:0006706)	2.67606440
19	Decreased central vision (HP:0007663)	2.66318990
20	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.57678296
21	Methylmalonic aciduria (HP:0012120)	2.55290959
22	Attenuation of retinal blood vessels (HP:0007843)	2.53512659
23	Abnormal rod and cone electroretinograms (HP:0008323)	2.50510577
24	Hyperventilation (HP:0002883)	2.47190450
25	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.42394584
26	Abnormality of alanine metabolism (HP:0010916)	2.42394584
27	Hyperalaninemia (HP:0003348)	2.42394584
28	Tubular atrophy (HP:0000092)	2.38187378
29	3-Methylglutaconic aciduria (HP:0003535)	2.36800240
30	Increased corneal curvature (HP:0100692)	2.36484835
31	Keratoconus (HP:0000563)	2.36484835
32	Agitation (HP:0000713)	2.35157396
33	Medial flaring of the eyebrow (HP:0010747)	2.34922308
34	Sclerocornea (HP:0000647)	2.33003915
35	Inability to walk (HP:0002540)	2.29756913
36	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.25174900
37	Asplenia (HP:0001746)	2.24306793
38	Furrowed tongue (HP:0000221)	2.23390172
39	Congenital sensorineural hearing impairment (HP:0008527)	2.23252283
40	Polydipsia (HP:0001959)	2.21975475
41	Abnormal drinking behavior (HP:0030082)	2.21975475
42	Renal cortical cysts (HP:0000803)	2.20299573
43	Anencephaly (HP:0002323)	2.18407104
44	Broad-based gait (HP:0002136)	2.15627172
45	Febrile seizures (HP:0002373)	2.13788390
46	Progressive inability to walk (HP:0002505)	2.13430318
47	Abnormal biliary tract physiology (HP:0012439)	2.10698786
48	Bile duct proliferation (HP:0001408)	2.10698786
49	Lissencephaly (HP:0001339)	2.08538193
50	Clumsiness (HP:0002312)	2.05852524
51	Congenital hepatic fibrosis (HP:0002612)	2.04201107
52	Aplasia/Hypoplasia of the patella (HP:0006498)	2.02141733
53	Chorioretinal atrophy (HP:0000533)	2.00595216
54	Focal motor seizures (HP:0011153)	1.99590041
55	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.95838588
56	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.95359315
57	Small hand (HP:0200055)	1.94867650
58	Hemiparesis (HP:0001269)	1.94723772
59	Decreased circulating renin level (HP:0003351)	1.94169683
60	Focal seizures (HP:0007359)	1.93373050
61	Absent/shortened dynein arms (HP:0200106)	1.92721394
62	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.92721394
63	Congenital, generalized hypertrichosis (HP:0004540)	1.92498166
64	Male pseudohermaphroditism (HP:0000037)	1.92466820
65	Protruding tongue (HP:0010808)	1.92072981
66	Patellar aplasia (HP:0006443)	1.90637957
67	Acute necrotizing encephalopathy (HP:0006965)	1.90485610
68	Bony spicule pigmentary retinopathy (HP:0007737)	1.90354842
69	Abnormality of the renal collecting system (HP:0004742)	1.89924617
70	Hyperglycinemia (HP:0002154)	1.88962807
71	Absent thumb (HP:0009777)	1.88318848
72	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.88119629
73	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.85266073
74	Short 1st metacarpal (HP:0010034)	1.85266073
75	Gait imbalance (HP:0002141)	1.84938729
76	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.84884108
77	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.80667681
78	Stomach cancer (HP:0012126)	1.79529314
79	Visual hallucinations (HP:0002367)	1.78578999
80	Concave nail (HP:0001598)	1.78002788
81	Optic nerve hypoplasia (HP:0000609)	1.77706629
82	Progressive macrocephaly (HP:0004481)	1.77188805
83	Absent speech (HP:0001344)	1.76725530
84	Polyuria (HP:0000103)	1.74798928
85	Mitochondrial inheritance (HP:0001427)	1.74413549
86	Retinal dysplasia (HP:0007973)	1.74221754
87	Homocystinuria (HP:0002156)	1.73963234
88	Abnormality of homocysteine metabolism (HP:0010919)	1.73963234
89	Thyroid-stimulating hormone excess (HP:0002925)	1.73665774
90	Congenital primary aphakia (HP:0007707)	1.73427574
91	Nephrogenic diabetes insipidus (HP:0009806)	1.72332416
92	Epileptic encephalopathy (HP:0200134)	1.70152529
93	Acute encephalopathy (HP:0006846)	1.70116204
94	Increased CSF lactate (HP:0002490)	1.69681724
95	Pachygyria (HP:0001302)	1.69651563
96	Abnormality of vitamin B metabolism (HP:0004340)	1.69249121
97	Confusion (HP:0001289)	1.69104308
98	Postaxial foot polydactyly (HP:0001830)	1.68975433
99	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.68524476
100	Severe visual impairment (HP:0001141)	1.68216304

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.49944407
2	ADRBK2	3.24049596
3	GRK1	2.87848165
4	WNK3	2.83080677
5	BMPR1B	2.48744145
6	PINK1	2.44761388
7	NUAK1	2.36927726
8	MAP4K2	2.30434438
9	ZAK	2.26405726
10	TLK1	2.17130815
11	TAOK3	2.17102427
12	MAPK13	2.15792051
13	ACVR1B	2.08433182
14	WNK4	2.08253095
15	INSRR	1.78265089
16	MAP3K4	1.77333786
17	CASK	1.62112524
18	DAPK2	1.39229051
19	TXK	1.38724837
20	OXSR1	1.38708772
21	MKNK2	1.38557111
22	MARK1	1.37320918
23	SIK2	1.28619709
24	PLK2	1.25675252
25	DYRK2	1.25001467
26	NTRK3	1.12556337
27	PLK4	1.11550555
28	AKT3	1.10383304
29	NTRK2	1.09600170
30	ADRBK1	1.04999670
31	PAK3	1.04947937
32	CSNK1G2	1.01071092
33	FGFR2	1.00451414
34	TIE1	0.97023407
35	PRKCG	0.96473445
36	STK16	0.93332668
37	STK39	0.93070503
38	CSNK1G3	0.88145734
39	MAP2K7	0.87787687
40	CAMKK2	0.86776971
41	TNIK	0.85121772
42	NME1	0.84969929
43	CSNK1G1	0.81816393
44	EPHA4	0.79709889
45	TNK2	0.79143744
46	CSNK1A1L	0.79088019
47	MAPKAPK3	0.76653981
48	PRKCE	0.76421526
49	CAMK1	0.74103851
50	NEK2	0.72993056
51	MAP2K6	0.71409349
52	TEC	0.70827017
53	STK11	0.69654043
54	PHKG2	0.68558022
55	PHKG1	0.68558022
56	ERBB2	0.68061352
57	TGFBR1	0.66853861
58	SGK2	0.65626900
59	MKNK1	0.64506089
60	SGK223	0.63045184
61	SGK494	0.63045184
62	PKN1	0.62982178
63	MAPKAPK5	0.62798907
64	CAMK2A	0.61529505
65	PRKD2	0.59334730
66	PIK3CA	0.58278160
67	PRKCQ	0.57891274
68	PRKACA	0.56889544
69	ATR	0.56850609
70	RPS6KA5	0.56444749
71	CSNK1A1	0.54839993
72	GRK5	0.53024488
73	VRK1	0.52680243
74	SGK1	0.51412154
75	PTK2B	0.50570919
76	KIT	0.50516129
77	PNCK	0.50117791
78	IKBKB	0.50016280
79	CAMKK1	0.49034764
80	BCKDK	0.48671557
81	TRIM28	0.48440374
82	PRKCZ	0.46393516
83	WNK1	0.46247868
84	CSNK1D	0.46005611
85	BRSK2	0.45972449
86	MUSK	0.45478028
87	SYK	0.45284005
88	BCR	0.45246857
89	OBSCN	0.43840303
90	PLK3	0.43714709
91	DYRK1A	0.43605041
92	CHEK2	0.42303528
93	FLT3	0.40577816
94	PRKCA	0.39144289
95	GRK6	0.38916865
96	PRKAA1	0.38307438
97	STK38L	0.37989244
98	GRK7	0.37464100
99	MAP3K7	0.36191266
100	ITK	0.35906870

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.14600535
2	Phototransduction_Homo sapiens_hsa04744	2.90893009
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.89966069
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.49339614
5	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.30000290
6	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.19311882
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.16977234
8	Homologous recombination_Homo sapiens_hsa03440	2.15259188
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.03187661
10	Morphine addiction_Homo sapiens_hsa05032	2.01609978
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.00664759
12	Oxidative phosphorylation_Homo sapiens_hsa00190	1.93752386
13	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.90558961
14	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.87607300
15	Selenocompound metabolism_Homo sapiens_hsa00450	1.86553824
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.84281947
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.83015284
18	Butanoate metabolism_Homo sapiens_hsa00650	1.77792173
19	Taste transduction_Homo sapiens_hsa04742	1.77088045
20	Olfactory transduction_Homo sapiens_hsa04740	1.75383037
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.67104666
22	GABAergic synapse_Homo sapiens_hsa04727	1.58422173
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.53931603
24	RNA polymerase_Homo sapiens_hsa03020	1.53802824
25	Basal transcription factors_Homo sapiens_hsa03022	1.52520134
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.49973611
27	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.46979904
28	RNA degradation_Homo sapiens_hsa03018	1.46891762
29	Parkinsons disease_Homo sapiens_hsa05012	1.46371025
30	Glutamatergic synapse_Homo sapiens_hsa04724	1.45260357
31	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.44166042
32	Circadian entrainment_Homo sapiens_hsa04713	1.40793781
33	Protein export_Homo sapiens_hsa03060	1.33364871
34	Insulin secretion_Homo sapiens_hsa04911	1.31824715
35	Caffeine metabolism_Homo sapiens_hsa00232	1.28500432
36	One carbon pool by folate_Homo sapiens_hsa00670	1.26648504
37	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.21492210
38	Cardiac muscle contraction_Homo sapiens_hsa04260	1.18390988
39	Serotonergic synapse_Homo sapiens_hsa04726	1.16459373
40	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.12209627
41	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.04168325
42	Regulation of autophagy_Homo sapiens_hsa04140	1.00063575
43	Chemical carcinogenesis_Homo sapiens_hsa05204	0.99706535
44	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.98392712
45	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.98088601
46	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.97275034
47	Alzheimers disease_Homo sapiens_hsa05010	0.96463959
48	Glycerolipid metabolism_Homo sapiens_hsa00561	0.92475926
49	Calcium signaling pathway_Homo sapiens_hsa04020	0.92241562
50	Retinol metabolism_Homo sapiens_hsa00830	0.90581928
51	Peroxisome_Homo sapiens_hsa04146	0.90360120
52	Dopaminergic synapse_Homo sapiens_hsa04728	0.89756060
53	Huntingtons disease_Homo sapiens_hsa05016	0.88699163
54	Asthma_Homo sapiens_hsa05310	0.88690335
55	Propanoate metabolism_Homo sapiens_hsa00640	0.84808558
56	Salivary secretion_Homo sapiens_hsa04970	0.82030978
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.79222843
58	ABC transporters_Homo sapiens_hsa02010	0.78204393
59	Cholinergic synapse_Homo sapiens_hsa04725	0.77896119
60	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.77000536
61	Sulfur metabolism_Homo sapiens_hsa00920	0.73880436
62	Collecting duct acid secretion_Homo sapiens_hsa04966	0.73724857
63	Sulfur relay system_Homo sapiens_hsa04122	0.69925683
64	beta-Alanine metabolism_Homo sapiens_hsa00410	0.67217518
65	Amphetamine addiction_Homo sapiens_hsa05031	0.66385396
66	Cocaine addiction_Homo sapiens_hsa05030	0.65808717
67	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.65766930
68	Type II diabetes mellitus_Homo sapiens_hsa04930	0.65346839
69	Ribosome_Homo sapiens_hsa03010	0.64915504
70	Primary immunodeficiency_Homo sapiens_hsa05340	0.63376676
71	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.61363715
72	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.59423095
73	Purine metabolism_Homo sapiens_hsa00230	0.59003547
74	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.58507219
75	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.55830117
76	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.54160044
77	Long-term depression_Homo sapiens_hsa04730	0.54100035
78	Fat digestion and absorption_Homo sapiens_hsa04975	0.53628120
79	cAMP signaling pathway_Homo sapiens_hsa04024	0.53574743
80	Gastric acid secretion_Homo sapiens_hsa04971	0.51736553
81	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.50540137
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.49797731
83	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.47790859
84	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.46802740
85	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.46728340
86	Type I diabetes mellitus_Homo sapiens_hsa04940	0.46510869
87	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.46345777
88	Metabolic pathways_Homo sapiens_hsa01100	0.45994764
89	Non-homologous end-joining_Homo sapiens_hsa03450	0.42466203
90	Histidine metabolism_Homo sapiens_hsa00340	0.42420716
91	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.41722330
92	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.39966046
93	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39874750
94	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.39533892
95	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.37926116
96	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.35857648
97	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.35753317
98	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.35613616
99	Melanoma_Homo sapiens_hsa05218	0.35540973
100	Graft-versus-host disease_Homo sapiens_hsa05332	0.35484377

SGK494

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »