SGMS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is predicted to be a five-pass transmembrane protein. This gene may be predominately expressed in brain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phospholipid scrambling (GO:0017121)6.96542833
2definitive hemopoiesis (GO:0060216)5.68977366
3detection of bacterium (GO:0016045)5.53449355
4detection of other organism (GO:0098543)5.46157824
5motile cilium assembly (GO:0044458)4.91971611
6endothelium development (GO:0003158)4.77799859
7lymph vessel development (GO:0001945)4.74648927
8muscle organ morphogenesis (GO:0048644)4.60750947
9vascular endothelial growth factor signaling pathway (GO:0038084)4.42892734
10iron ion import (GO:0097286)4.27596727
11surfactant homeostasis (GO:0043129)4.21139645
12regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.09135365
13platelet dense granule organization (GO:0060155)4.08616342
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.97913588
15neutrophil activation involved in immune response (GO:0002283)3.88926721
16regulation of antigen processing and presentation (GO:0002577)3.84437546
17negative regulation of nitric oxide biosynthetic process (GO:0045019)3.84265228
18detection of molecule of bacterial origin (GO:0032490)3.84011420
19response to peptidoglycan (GO:0032494)3.81501550
20regulation of cellular extravasation (GO:0002691)3.76709710
21peptidyl-tyrosine autophosphorylation (GO:0038083)3.74349319
22axonemal dynein complex assembly (GO:0070286)3.71640017
23regulation of dendritic cell antigen processing and presentation (GO:0002604)3.66796246
24positive regulation of antigen processing and presentation (GO:0002579)3.60848809
25cellular response to thyroid hormone stimulus (GO:0097067)3.59771481
26lipopolysaccharide-mediated signaling pathway (GO:0031663)3.58584413
27detection of external biotic stimulus (GO:0098581)3.56627300
28negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.52581464
29negative regulation of T-helper cell differentiation (GO:0045623)3.52581464
30negative regulation of stress fiber assembly (GO:0051497)3.41740539
31negative regulation of erythrocyte differentiation (GO:0045647)3.41578647
32positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.39868770
33detection of biotic stimulus (GO:0009595)3.38457939
34oligosaccharide catabolic process (GO:0009313)3.34977092
35protein localization to endosome (GO:0036010)3.34041610
36embryonic process involved in female pregnancy (GO:0060136)3.33464797
37sprouting angiogenesis (GO:0002040)3.27190876
38chemical homeostasis within a tissue (GO:0048875)3.27034603
39response to thyroid hormone (GO:0097066)3.23529136
40macrophage activation involved in immune response (GO:0002281)3.19946462
41germ cell migration (GO:0008354)3.14734875
42glycosphingolipid catabolic process (GO:0046479)3.14624326
43positive regulation of vasculogenesis (GO:2001214)3.12629696
44positive regulation of respiratory burst (GO:0060267)3.10400008
45positive regulation of gamma-delta T cell activation (GO:0046645)3.05316728
46NIK/NF-kappaB signaling (GO:0038061)3.05241097
47negative regulation of nitric-oxide synthase activity (GO:0051001)3.03770036
48regulation of T-helper 2 cell differentiation (GO:0045628)3.01427287
49negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.01089456
50modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.97065028
51modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.97065028
52positive regulation by organism of defense response of other organism involved in symbiotic interact2.97065028
53modulation by symbiont of host immune response (GO:0052553)2.97065028
54positive regulation by symbiont of host defense response (GO:0052509)2.97065028
55modulation by symbiont of host defense response (GO:0052031)2.97065028
56cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.96411249
57negative regulation of interleukin-12 production (GO:0032695)2.95332940
58cellular response to arsenic-containing substance (GO:0071243)2.88674107
59regulation of T-helper 1 cell differentiation (GO:0045625)2.87209029
60T-helper cell differentiation (GO:0042093)2.85447495
61CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.85447495
62glycolipid catabolic process (GO:0019377)2.84964390
63fusion of sperm to egg plasma membrane (GO:0007342)2.83803998
64positive regulation of chemokine biosynthetic process (GO:0045080)2.82905251
65blood vessel maturation (GO:0001955)2.81295969
66positive regulation of T cell migration (GO:2000406)2.80667959
67regulation of vasculogenesis (GO:2001212)2.80477555
68regulation of membrane lipid distribution (GO:0097035)2.80294640
69cellular response to ethanol (GO:0071361)2.80118756
70monocyte chemotaxis (GO:0002548)2.77974774
71protoporphyrinogen IX metabolic process (GO:0046501)2.74867907
72regulation of interferon-beta biosynthetic process (GO:0045357)2.74495536
73positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.72604580
74regulation of necroptotic process (GO:0060544)2.71279284
75regulation of interferon-alpha production (GO:0032647)2.70801290
76vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.69064540
77negative regulation of actin filament bundle assembly (GO:0032232)2.68440067
78positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.67746708
79establishment of endothelial barrier (GO:0061028)2.66946609
80T-helper 1 type immune response (GO:0042088)2.65723877
81regulation of chemokine biosynthetic process (GO:0045073)2.65689605
82cell wall macromolecule metabolic process (GO:0044036)2.65422715
83cell wall macromolecule catabolic process (GO:0016998)2.65422715
84CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.65167917
85negative regulation of protein localization to plasma membrane (GO:1903077)2.64243595
86patterning of blood vessels (GO:0001569)2.64066218
87regulation of mononuclear cell migration (GO:0071675)2.62484647
88phagocytosis, engulfment (GO:0006911)2.62446622
89positive regulation of interferon-alpha production (GO:0032727)2.62276702
90cytokine biosynthetic process (GO:0042089)2.60853655
91germinal center formation (GO:0002467)2.59909335
92regulation of macrophage chemotaxis (GO:0010758)2.59299328
93secretory granule organization (GO:0033363)2.58715464
94endothelial tube morphogenesis (GO:0061154)2.57707304
95morphogenesis of an endothelium (GO:0003159)2.57707304
96artery smooth muscle contraction (GO:0014824)2.57021407
97megakaryocyte development (GO:0035855)2.54856054
98low-density lipoprotein particle clearance (GO:0034383)2.54163493
99immunoglobulin mediated immune response (GO:0016064)2.53791022
100defense response to protozoan (GO:0042832)2.53307682
101response to laminar fluid shear stress (GO:0034616)2.52837520
102JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.52037020
103positive regulation of macrophage cytokine production (GO:0060907)2.51484179
104regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.51373736
105positive regulation of lymphocyte migration (GO:2000403)2.50669998
106positive regulation of type 2 immune response (GO:0002830)2.50601396
107positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.50100303
108radial glial cell differentiation (GO:0060019)2.48935023
109regulation of T cell migration (GO:2000404)2.48216833
110regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.48072858
111response to muramyl dipeptide (GO:0032495)2.47418453
112histamine secretion (GO:0001821)2.47133452
113regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.46794066
114negative regulation of lipid storage (GO:0010888)2.46226414
115lymphangiogenesis (GO:0001946)2.45542533
116sodium-independent organic anion transport (GO:0043252)2.45517993
117positive regulation of monocyte chemotaxis (GO:0090026)2.45187137
118response to protozoan (GO:0001562)2.45099942
119negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.44795217
120COPI coating of Golgi vesicle (GO:0048205)2.44201168
121Golgi transport vesicle coating (GO:0048200)2.44201168
122toxin transport (GO:1901998)2.44037647
123positive regulation of cellular amide metabolic process (GO:0034250)2.43575647
124cytokine secretion (GO:0050663)2.43415160
125regulation of chronic inflammatory response (GO:0002676)2.41750988
126response to interferon-alpha (GO:0035455)2.41560144
127mast cell activation (GO:0045576)2.41180472
128tonic smooth muscle contraction (GO:0014820)2.40700550
129regulation of vitamin D biosynthetic process (GO:0060556)2.40604433
130regulation of membrane protein ectodomain proteolysis (GO:0051043)2.40548058
131regulation of germinal center formation (GO:0002634)2.39059969
132ovulation from ovarian follicle (GO:0001542)2.38661646
133negative regulation of interleukin-17 production (GO:0032700)2.38525143
134macrophage activation (GO:0042116)2.37377635
135necroptotic process (GO:0070266)2.37224746
136regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.37004683
137phagocytosis, recognition (GO:0006910)2.36039341
138Notch receptor processing (GO:0007220)2.35890097
139plasma membrane fusion (GO:0045026)2.35696378
140sphingoid metabolic process (GO:0046519)2.35526154
141mRNA transcription from RNA polymerase II promoter (GO:0042789)2.35463198
142gas transport (GO:0015669)2.34640939
143response to type I interferon (GO:0034340)2.34382234
144endothelial cell differentiation (GO:0045446)2.34318860
145sperm motility (GO:0030317)2.33755055
146embryonic camera-type eye morphogenesis (GO:0048596)2.33218431
147regulation of response to interferon-gamma (GO:0060330)2.32752060
148positive regulation of p38MAPK cascade (GO:1900745)2.31691659
149alpha-linolenic acid metabolic process (GO:0036109)2.31675568
150endosome to melanosome transport (GO:0035646)2.31542681
151endosome to pigment granule transport (GO:0043485)2.31542681
152negative regulation of endothelial cell apoptotic process (GO:2000352)2.30994580
153antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.30311287
154antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.30311287
155nuclear pore complex assembly (GO:0051292)2.30087502
156regulation of B cell receptor signaling pathway (GO:0050855)2.29606531
157cytokine metabolic process (GO:0042107)2.29494773
158Notch signaling involved in heart development (GO:0061314)2.29217556
159ceramide catabolic process (GO:0046514)2.29123053
160N-acetylneuraminate metabolic process (GO:0006054)2.28906188
161granulocyte activation (GO:0036230)2.28834154
162alpha-beta T cell differentiation involved in immune response (GO:0002293)2.28771904
163alpha-beta T cell activation involved in immune response (GO:0002287)2.28771904
164T cell differentiation involved in immune response (GO:0002292)2.28771904
165regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.28317410
166regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.28033933
167cellular extravasation (GO:0045123)2.27307442
168regulation of RIG-I signaling pathway (GO:0039535)2.26860925
169import into cell (GO:0098657)2.26171127
170positive regulation of interleukin-6 production (GO:0032755)2.25956222
171regulation of mast cell degranulation (GO:0043304)2.25433353
172regulation of necrotic cell death (GO:0010939)2.25161298
173negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.25030698
174regulation of early endosome to late endosome transport (GO:2000641)2.24933632
175cell adhesion mediated by integrin (GO:0033627)2.24229720
176hypotonic response (GO:0006971)2.23952805
177positive regulation of leukocyte degranulation (GO:0043302)2.21550714
178type I interferon signaling pathway (GO:0060337)2.21549859
179cellular response to type I interferon (GO:0071357)2.21549859
180positive regulation of Cdc42 GTPase activity (GO:0043089)2.20757687
181cytoskeletal anchoring at plasma membrane (GO:0007016)2.20661984
182regulation of podosome assembly (GO:0071801)2.20343581
183membrane raft organization (GO:0031579)2.20321474
184positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.19650212
185positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.18809205
186cellular response to interferon-alpha (GO:0035457)2.18422337
187regulation of macrophage cytokine production (GO:0010935)2.18328049
188negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.17827535
189hepatocyte apoptotic process (GO:0097284)2.17677936
190interferon-gamma-mediated signaling pathway (GO:0060333)2.17665008

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_19346495_ChIP-Seq_HPC-7_Human4.13756430
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.77079153
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.73674327
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.67604680
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.57966963
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.56237462
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.52095449
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.50523185
9* GATA2_21666600_ChIP-Seq_HMVEC_Human3.27810987
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.97167589
11* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.70728595
12RUNX_20019798_ChIP-Seq_JUKART_Human2.56334325
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.50833075
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.45566754
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.42619879
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.25192936
17CLOCK_20551151_ChIP-Seq_293T_Human2.17350669
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.12284298
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.11677621
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.11061682
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.10390568
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04281332
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.98298748
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.96576767
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91497991
26BRD4_27068464_Chip-Seq_AML-cells_Mouse1.88915494
27* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.83769631
28SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.80321506
29LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.79019827
30* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.77632768
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75647617
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.75383331
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74194154
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.73829716
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.70397834
36VDR_24787735_ChIP-Seq_THP-1_Human1.65907365
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.62232495
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61689545
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60723581
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.59538516
41SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.59383867
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.56752550
43* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56028895
44CJUN_26792858_Chip-Seq_BT549_Human1.53657094
45FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.49862253
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.49654174
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.48091994
48* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.46811838
49* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.46811838
50* TFEB_21752829_ChIP-Seq_HELA_Human1.46222860
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45728818
52* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45388344
53* EP300_21415370_ChIP-Seq_HL-1_Mouse1.44005614
54CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.43407388
55GATA1_22025678_ChIP-Seq_K562_Human1.41826802
56* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41546656
57* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.41246294
58NCOR1_26117541_ChIP-Seq_K562_Human1.41178996
59* LXR_22158963_ChIP-Seq_LIVER_Mouse1.41120014
60RXR_22158963_ChIP-Seq_LIVER_Mouse1.39052749
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38599384
62STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37884780
63* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37670387
64HIF1A_21447827_ChIP-Seq_MCF-7_Human1.35853274
65PPAR_26484153_Chip-Seq_NCI-H1993_Human1.33793866
66CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.33792052
67ZNF263_19887448_ChIP-Seq_K562_Human1.29264271
68* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.28447439
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27807561
70ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.26637833
71* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26471172
72ESR1_20079471_ChIP-ChIP_T-47D_Human1.25003458
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23093498
74SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22542330
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19637686
76FLI1_27457419_Chip-Seq_LIVER_Mouse1.19594858
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19094718
78SOX2_20726797_ChIP-Seq_SW620_Human1.19003415
79MYB_26560356_Chip-Seq_TH2_Human1.18674548
80* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16913719
81FOXO3_23340844_ChIP-Seq_DLD1_Human1.16627288
82* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15870309
83PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14967871
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14909858
85* GATA2_19941826_ChIP-Seq_K562_Human1.14823874
86AR_21909140_ChIP-Seq_LNCAP_Human1.14753439
87RXR_22108803_ChIP-Seq_LS180_Human1.14221747
88* GATA1_19941826_ChIP-Seq_K562_Human1.13338071
89TCF4_18268006_ChIP-ChIP_LS174T_Human1.10973742
90FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.10527835
91TCF7_22412390_ChIP-Seq_EML_Mouse1.10517648
92PPARA_22158963_ChIP-Seq_LIVER_Mouse1.07740257
93* GATA3_26560356_Chip-Seq_TH2_Human1.07314403
94JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07312851
95* SPI1_23127762_ChIP-Seq_K562_Human1.07167185
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06794094
97GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06317099
98* MAF_26560356_Chip-Seq_TH1_Human1.05815016
99JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04698300
100SPI1_23547873_ChIP-Seq_NB4_Human1.04539519
101* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02991553
102MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02936865
103TBX20_22080862_ChIP-Seq_HEART_Mouse1.02424731
104TBX20_22328084_ChIP-Seq_HEART_Mouse1.02424731
105RUNX1_22412390_ChIP-Seq_EML_Mouse1.01900116
106STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01749141
107FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00305739
108PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99760227
109PU_27001747_Chip-Seq_BMDM_Mouse0.99331168
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98547424
111* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98410887
112BRD4_25478319_ChIP-Seq_HGPS_Human0.98184920
113NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98154391
114NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98154391
115* ELK3_25401928_ChIP-Seq_HUVEC_Human0.98025649
116PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97875342
117NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96484249
118CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96406233
119EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.95871466
120WT1_19549856_ChIP-ChIP_CCG9911_Human0.95744339
121TP53_18474530_ChIP-ChIP_U2OS_Human0.95261039
122TP63_23658742_ChIP-Seq_EP156T_Human0.93669397
123* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92245532
124CDX2_20551321_ChIP-Seq_CACO-2_Human0.91707794
125SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91448340
126* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91080362
127GATA1_19941827_ChIP-Seq_MEL_Mouse0.90865044
128VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90295830
129CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89953375
130KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.89539977
131VDR_24763502_ChIP-Seq_THP-1_Human0.85991834
132* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85490865
133* MYB_26560356_Chip-Seq_TH1_Human0.85437023
134CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84313592
135E2F1_18555785_Chip-Seq_ESCs_Mouse0.83773439
136EZH2_27294783_Chip-Seq_NPCs_Mouse0.83529158
137IGF1R_20145208_ChIP-Seq_DFB_Human0.83362157
138TAF15_26573619_Chip-Seq_HEK293_Human0.83311742
139TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.81920946
140* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81332767

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow3.92570782
2MP0004147_increased_porphyrin_level3.49198319
3MP0005167_abnormal_blood-brain_barrier3.34168518
4MP0001879_abnormal_lymphatic_vessel3.10525030
5MP0009379_abnormal_foot_pigmentation3.08302383
6MP0003303_peritoneal_inflammation3.06624453
7MP0001873_stomach_inflammation3.03357044
8MP0003656_abnormal_erythrocyte_physiolo2.97177076
9MP0003950_abnormal_plasma_membrane2.96608739
10MP0003724_increased_susceptibility_to2.92810998
11MP0010368_abnormal_lymphatic_system2.84002007
12MP0001545_abnormal_hematopoietic_system2.62767945
13MP0005397_hematopoietic_system_phenotyp2.62767945
14MP0002009_preneoplasia2.57181348
15MP0005451_abnormal_body_composition2.39334561
16MP0005058_abnormal_lysosome_morphology2.29432912
17MP0001835_abnormal_antigen_presentation2.23355958
18MP0003828_pulmonary_edema2.10443742
19MP0001188_hyperpigmentation2.06963321
20MP0008438_abnormal_cutaneous_collagen1.98604382
21MP0009840_abnormal_foam_cell1.98333919
22MP0005410_abnormal_fertilization1.98101972
23MP0003941_abnormal_skin_development1.97252127
24MP0010234_abnormal_vibrissa_follicle1.93511226
25MP0003453_abnormal_keratinocyte_physiol1.93141276
26MP0008004_abnormal_stomach_pH1.90837780
27MP0004808_abnormal_hematopoietic_stem1.89668099
28MP0003191_abnormal_cellular_cholesterol1.87790695
29MP0003705_abnormal_hypodermis_morpholog1.81024100
30MP0002419_abnormal_innate_immunity1.71388219
31MP0010352_gastrointestinal_tract_polyps1.71270421
32MP0009697_abnormal_copulation1.69811637
33MP0009785_altered_susceptibility_to1.67674641
34MP0002148_abnormal_hypersensitivity_rea1.66887886
35MP0008995_early_reproductive_senescence1.64500422
36MP0002166_altered_tumor_susceptibility1.64347411
37MP0008260_abnormal_autophagy1.63133593
38MP0002332_abnormal_exercise_endurance1.61148758
39MP0005275_abnormal_skin_tensile1.61053339
40MP0004484_altered_response_of1.60656322
41MP0005464_abnormal_platelet_physiology1.60101555
42MP0001853_heart_inflammation1.59844044
43MP0003300_gastrointestinal_ulcer1.58201805
44MP0003943_abnormal_hepatobiliary_system1.56395433
45MP0004510_myositis1.53453789
46MP0002452_abnormal_antigen_presenting1.52318435
47MP0005670_abnormal_white_adipose1.51285139
48MP0005084_abnormal_gallbladder_morpholo1.51093629
49MP0003075_altered_response_to1.48313025
50MP0002006_tumorigenesis1.48072633
51MP0002796_impaired_skin_barrier1.47311428
52MP0005171_absent_coat_pigmentation1.46691368
53MP0006054_spinal_hemorrhage1.46302436
54MP0004947_skin_inflammation1.45876481
55MP0002139_abnormal_hepatobiliary_system1.45860939
56MP0005025_abnormal_response_to1.44558173
57MP0003279_aneurysm1.43501036
58MP0005409_darkened_coat_color1.43114878
59MP0003436_decreased_susceptibility_to1.41470953
60MP0005671_abnormal_response_to1.40794388
61MP0000858_altered_metastatic_potential1.40657802
62MP0003566_abnormal_cell_adhesion1.40100032
63MP0000465_gastrointestinal_hemorrhage1.39780036
64MP0005387_immune_system_phenotype1.39707572
65MP0001790_abnormal_immune_system1.39707572
66MP0004272_abnormal_basement_membrane1.33783656
67MP0002396_abnormal_hematopoietic_system1.31212715
68MP0004782_abnormal_surfactant_physiolog1.31043934
69MP0000372_irregular_coat_pigmentation1.30865669
70MP0008057_abnormal_DNA_replication1.30814795
71MP0005000_abnormal_immune_tolerance1.30154978
72MP0002723_abnormal_immune_serum1.27010476
73MP0005165_increased_susceptibility_to1.26645816
74MP0001819_abnormal_immune_cell1.24510080
75MP0002420_abnormal_adaptive_immunity1.24475512
76MP0004381_abnormal_hair_follicle1.24400595
77MP0001851_eye_inflammation1.23879861
78MP0001800_abnormal_humoral_immune1.22309591
79MP0000015_abnormal_ear_pigmentation1.20067624
80MP0005083_abnormal_biliary_tract1.19033046
81MP0005174_abnormal_tail_pigmentation1.18729198
82MP0000249_abnormal_blood_vessel1.17657714
83MP0002405_respiratory_system_inflammati1.15712566
84MP0009764_decreased_sensitivity_to1.15070301
85MP0005501_abnormal_skin_physiology1.14294287
86MP0003690_abnormal_glial_cell1.13980235
87MP0010155_abnormal_intestine_physiology1.13451415
88MP0003183_abnormal_peptide_metabolism1.13137165
89MP0000767_abnormal_smooth_muscle1.12707563
90MP0004883_abnormal_blood_vessel1.11378601
91MP0005310_abnormal_salivary_gland1.11377108
92MP0003091_abnormal_cell_migration1.11203845
93MP0005076_abnormal_cell_differentiation1.09998037
94MP0003172_abnormal_lysosome_physiology1.09291434
95MP0005023_abnormal_wound_healing1.09045321
96MP0003806_abnormal_nucleotide_metabolis1.08545140
97MP0005075_abnormal_melanosome_morpholog1.05013234
98MP0000343_altered_response_to1.04748990
99MP0000685_abnormal_immune_system1.02167156
100MP0002254_reproductive_system_inflammat0.95948047
101MP0000604_amyloidosis0.95544449
102MP0006082_CNS_inflammation0.92587498
103MP0005666_abnormal_adipose_tissue0.92435526
104MP0009763_increased_sensitivity_to0.92240336
105MP0002098_abnormal_vibrissa_morphology0.92149565
106MP0001845_abnormal_inflammatory_respons0.91998018
107MP0001533_abnormal_skeleton_physiology0.89561911
108MP0002928_abnormal_bile_duct0.89173213
109MP0001216_abnormal_epidermal_layer0.88075840
110MP0001191_abnormal_skin_condition0.86084061
111MP0004233_abnormal_muscle_weight0.85743355
112MP0004264_abnormal_extraembryonic_tissu0.85542333
113MP0005595_abnormal_vascular_smooth0.85491609
114MP0006138_congestive_heart_failure0.84654204
115MP0002998_abnormal_bone_remodeling0.83999577
116MP0002398_abnormal_bone_marrow0.83899513
117MP0010678_abnormal_skin_adnexa0.83627833
118MP0001958_emphysema0.83258868
119MP0009115_abnormal_fat_cell0.81654414
120MP0005166_decreased_susceptibility_to0.81584490
121MP0010630_abnormal_cardiac_muscle0.81487241
122MP0004185_abnormal_adipocyte_glucose0.81431998
123MP0002128_abnormal_blood_circulation0.81221618
124MP0008007_abnormal_cellular_replicative0.80767897
125MP0002132_abnormal_respiratory_system0.78381834
126MP0000609_abnormal_liver_physiology0.78277122
127MP0005164_abnormal_response_to0.78215577
128MP0003448_altered_tumor_morphology0.77494287
129MP0000716_abnormal_immune_system0.77450326
130MP0002095_abnormal_skin_pigmentation0.77299110
131MP0002060_abnormal_skin_morphology0.76440201
132MP0003795_abnormal_bone_structure0.76024202
133MP0002295_abnormal_pulmonary_circulatio0.74628835
134MP0002136_abnormal_kidney_physiology0.74061213
135MP0002877_abnormal_melanocyte_morpholog0.72372548
136MP0000689_abnormal_spleen_morphology0.72058623
137MP0001919_abnormal_reproductive_system0.71469562
138MP0008469_abnormal_protein_level0.70906495
139MP0002429_abnormal_blood_cell0.70534715

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)6.67642140
2Absent/shortened dynein arms (HP:0200106)6.67642140
3Abnormality of the nasal mucosa (HP:0000433)4.85287424
4Nasal polyposis (HP:0100582)4.62212057
5Recurrent abscess formation (HP:0002722)4.37061891
6Abnormality of liposaccharide metabolism (HP:0010968)4.17681423
7Abnormality of glycosphingolipid metabolism (HP:0004343)4.17681423
8Abnormality of glycolipid metabolism (HP:0010969)4.17681423
9Abnormal respiratory motile cilium morphology (HP:0005938)3.98861031
10Abnormal respiratory epithelium morphology (HP:0012253)3.98861031
11Abnormal ciliary motility (HP:0012262)3.49280151
12Abnormal respiratory motile cilium physiology (HP:0012261)3.45646462
13Congenital, generalized hypertrichosis (HP:0004540)3.36377317
14Osteolytic defects of the phalanges of the hand (HP:0009771)3.29405064
15Osteolytic defects of the hand bones (HP:0009699)3.29405064
16Spontaneous hematomas (HP:0007420)3.14718247
17Portal hypertension (HP:0001409)3.13696164
18Petechiae (HP:0000967)3.12354698
19Myocardial infarction (HP:0001658)3.08465483
20Polycythemia (HP:0001901)3.07696459
21Recurrent bacterial skin infections (HP:0005406)2.96377432
22Myositis (HP:0100614)2.96015139
23Adactyly (HP:0009776)2.95387981
24Esophageal varix (HP:0002040)2.92282394
25Abnormality of the hepatic vasculature (HP:0006707)2.89990219
26Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.85310044
27Pulmonary artery stenosis (HP:0004415)2.85284854
28Prolonged bleeding time (HP:0003010)2.85141963
29Dysostosis multiplex (HP:0000943)2.80979031
30Hematochezia (HP:0002573)2.71327078
31Thick nail (HP:0001805)2.70556203
32Vacuolated lymphocytes (HP:0001922)2.66734371
33Eczematoid dermatitis (HP:0000976)2.66600249
34Prostate neoplasm (HP:0100787)2.64652760
35Hypoglycemic seizures (HP:0002173)2.60093897
36Elevated erythrocyte sedimentation rate (HP:0003565)2.58441858
37Systemic lupus erythematosus (HP:0002725)2.56785152
38Poikilocytosis (HP:0004447)2.52405961
39Mediastinal lymphadenopathy (HP:0100721)2.52277770
40Orchitis (HP:0100796)2.45533559
41Optic neuritis (HP:0100653)2.40557214
42Retrobulbar optic neuritis (HP:0100654)2.40557214
43Colitis (HP:0002583)2.39802306
44Aplasia cutis congenita (HP:0001057)2.39383877
45Papillary thyroid carcinoma (HP:0002895)2.39342981
46Facial diplegia (HP:0001349)2.39041290
47Autoimmune thrombocytopenia (HP:0001973)2.35137741
48Ankyloglossia (HP:0010296)2.31814522
49IgA deficiency (HP:0002720)2.30903222
50Loss of speech (HP:0002371)2.30314958
51Onycholysis (HP:0001806)2.30251845
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.26737399
53Abnormality of polysaccharide metabolism (HP:0011012)2.26737399
54Abnormality of glycosaminoglycan metabolism (HP:0004371)2.26737399
55Vertebral compression fractures (HP:0002953)2.24979116
56Urinary glycosaminoglycan excretion (HP:0003541)2.24930872
57Mucopolysacchariduria (HP:0008155)2.24930872
58Distal lower limb muscle weakness (HP:0009053)2.24630010
59Thrombocytosis (HP:0001894)2.23869580
60Lip pit (HP:0100267)2.23001503
61Absent hand (HP:0004050)2.22868828
62Epistaxis (HP:0000421)2.22818955
63Increased IgE level (HP:0003212)2.22690531
64Patchy hypopigmentation of hair (HP:0011365)2.21605211
65Pancreatic islet-cell hyperplasia (HP:0004510)2.19361384
66Acanthocytosis (HP:0001927)2.17583280
67Abnormality of the common coagulation pathway (HP:0010990)2.17052067
68Anhidrosis (HP:0000970)2.16671954
69Porencephaly (HP:0002132)2.16423986
70Atrial fibrillation (HP:0005110)2.15450476
71Impaired platelet aggregation (HP:0003540)2.13994353
72Abnormal platelet function (HP:0011869)2.13994353
73Fatigue (HP:0012378)2.13855837
74Hyperinsulinemic hypoglycemia (HP:0000825)2.13140514
75Bronchiectasis (HP:0002110)2.12916671
76Symptomatic seizures (HP:0011145)2.12336067
77White forelock (HP:0002211)2.11901294
78Disinhibition (HP:0000734)2.11658670
79Osteomyelitis (HP:0002754)2.10949651
80Mitral stenosis (HP:0001718)2.09740733
81Abnormality of the vasculature of the conjunctiva (HP:0008054)2.09150510
82Inflammation of the large intestine (HP:0002037)2.08808117
83Neurofibrillary tangles (HP:0002185)2.08321606
84Nonprogressive disorder (HP:0003680)2.07457612
85Tetraparesis (HP:0002273)2.06699211
86Increased serum ferritin (HP:0003281)2.05941186
87Abnormality of macrophages (HP:0004311)2.04655675
88Increased connective tissue (HP:0009025)2.04367044
89Stomatitis (HP:0010280)2.04277675
90Hypoglycemic coma (HP:0001325)2.03551265
91Abnormality of the frontal sinuses (HP:0002687)2.01587164
92Glomerulonephritis (HP:0000099)2.01193458
93Exercise-induced muscle cramps (HP:0003710)2.00755736
94Amyloidosis (HP:0011034)1.99666991
95Cerebral inclusion bodies (HP:0100314)1.97350479
96Chronic bronchitis (HP:0004469)1.92629259
97Arterial thrombosis (HP:0004420)1.92100756
98Axonal loss (HP:0003447)1.91800652
99Absent frontal sinuses (HP:0002688)1.91486974
100Acanthosis nigricans (HP:0000956)1.91297785
101Complement deficiency (HP:0004431)1.91244539
102Abnormality of secondary sexual hair (HP:0009888)1.89908978
103Abnormality of the axillary hair (HP:0100134)1.89908978
104Abnormality of oral frenula (HP:0000190)1.89401388
105Interstitial pulmonary disease (HP:0006530)1.88657526
106Abnormality of iron homeostasis (HP:0011031)1.88606993
107Infertility (HP:0000789)1.88359521
108Purpura (HP:0000979)1.88246256
109Primary atrial arrhythmia (HP:0001692)1.87406404
110Gingivitis (HP:0000230)1.87249677
111Abnormality of the heme biosynthetic pathway (HP:0010472)1.86526919
112Cellulitis (HP:0100658)1.85609286
113Reticulocytosis (HP:0001923)1.84272882
114Dilatation of the ascending aorta (HP:0005111)1.84247935
115Deep philtrum (HP:0002002)1.83810159
116Long foot (HP:0001833)1.82803248
117Hypergonadotropic hypogonadism (HP:0000815)1.82061666
118Keratoconjunctivitis sicca (HP:0001097)1.81013437
119Autoimmune hemolytic anemia (HP:0001890)1.80246873
120Bone pain (HP:0002653)1.80199282
121Abnormality of monocarboxylic acid metabolism (HP:0010996)1.79606278
122Pulmonary hypertension (HP:0002092)1.79448439
123Tetany (HP:0001281)1.78584030
124Gastrointestinal inflammation (HP:0004386)1.78541118
125Increased mean platelet volume (HP:0011877)1.78415836
126Slow saccadic eye movements (HP:0000514)1.77570687
127Spondylolisthesis (HP:0003302)1.77199548
128Abnormality of complement system (HP:0005339)1.76683781
129Chronic otitis media (HP:0000389)1.76608109
130Bronchitis (HP:0012387)1.76246530
131Paralysis (HP:0003470)1.76028331
132Supraventricular tachycardia (HP:0004755)1.75705968
133Supraventricular arrhythmia (HP:0005115)1.75524754
134Nonimmune hydrops fetalis (HP:0001790)1.75485719
135Abnormal platelet volume (HP:0011876)1.74698197
136Renal cortical cysts (HP:0000803)1.74484451
137Pulmonary infiltrates (HP:0002113)1.73288359
138Lower limb hyperreflexia (HP:0002395)1.73007018
139Abnormality of the renal cortex (HP:0011035)1.73006955
140Reduced subcutaneous adipose tissue (HP:0003758)1.72444169
141Increased cerebral lipofuscin (HP:0011813)1.72410201
142Abnormality of the periventricular white matter (HP:0002518)1.71608352
143Intrahepatic cholestasis (HP:0001406)1.71070534
144Vasculitis (HP:0002633)1.70909845
145Hemorrhage of the eye (HP:0011885)1.70224534
146Relative macrocephaly (HP:0004482)1.70119678
147Acute myeloid leukemia (HP:0004808)1.69398008
148Wormian bones (HP:0002645)1.69365494
149Urticaria (HP:0001025)1.69252904
150Ectropion (HP:0000656)1.68322595
151Personality changes (HP:0000751)1.67843298
152Hypertensive crisis (HP:0100735)1.67691850
153Recurrent skin infections (HP:0001581)1.66690255
154Microretrognathia (HP:0000308)1.66682162
155Menorrhagia (HP:0000132)1.66514913
156Weak cry (HP:0001612)1.66075799
157Autoamputation (HP:0001218)1.66073205
158Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.65925477
159Global brain atrophy (HP:0002283)1.65756506
160Abnormality of the prostate (HP:0008775)1.65610740
161Reduced antithrombin III activity (HP:0001976)1.65584710
162Recurrent bronchitis (HP:0002837)1.65324711
163Metaphyseal dysplasia (HP:0100255)1.65307215
164Hypertriglyceridemia (HP:0002155)1.64649070
165Progressive neurologic deterioration (HP:0002344)1.64035046
166Bruising susceptibility (HP:0000978)1.63824106
167Gingival bleeding (HP:0000225)1.63508162
168Recurrent gram-negative bacterial infections (HP:0005420)1.63464712
169Basal ganglia calcification (HP:0002135)1.63370822
170Coarse hair (HP:0002208)1.62874736
171Dysmetric saccades (HP:0000641)1.62665468
172Cholelithiasis (HP:0001081)1.62114651
173Cardiomegaly (HP:0001640)1.61386852
174Cardiovascular calcification (HP:0011915)1.60402187
175Steatorrhea (HP:0002570)1.60273986

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.56866156
2BMPR23.24363615
3INSRR3.21342391
4GRK13.00207083
5PRPF4B2.95355767
6KDR2.92272665
7NLK2.76675689
8TGFBR22.74669460
9TEC2.63785780
10IRAK32.41455456
11MAP3K122.22489629
12MAP3K142.20911349
13AKT32.08734148
14MAP3K21.97635789
15PDK21.95740071
16EIF2AK11.94358993
17MUSK1.93946340
18MYLK1.84963840
19MAP4K11.81676848
20ERN11.80877983
21SCYL21.79157110
22ZAK1.77643826
23TXK1.72020356
24KSR21.65432251
25TAOK21.50534588
26IRAK41.44070453
27IKBKE1.43638685
28KIT1.40248645
29TRPM71.38282004
30BLK1.30853026
31IKBKB1.29913976
32RAF11.27914533
33MAP3K11.26854905
34PIM11.22932975
35MAP3K31.22369109
36TBK11.20876921
37JAK21.18968124
38FRK1.18908423
39PDGFRA1.18734736
40DDR21.15325810
41MAPK151.14906094
42TYK21.14861250
43ICK1.14714195
44PRKG21.10351646
45CLK11.07794497
46CHUK1.06687840
47NUAK11.05931971
48BMPR1B1.05544474
49PIM21.04533495
50TGFBR11.03082715
51PDK31.02851012
52PDK41.02851012
53ARAF1.02838568
54CDK121.02323542
55MAPK71.02238143
56CDK91.01650038
57MAP2K30.98569387
58OBSCN0.97696919
59ITK0.97032985
60RIPK40.96979378
61PINK10.94960977
62TAOK10.93530261
63BMX0.92223043
64BTK0.91870325
65TRIB30.90687315
66JAK30.88585316
67BRAF0.87370895
68TAOK30.87140978
69NME20.86817124
70NEK60.86448963
71PTK2B0.86403053
72EIF2AK30.84504012
73PIK3CG0.84002088
74CAMK1D0.83660618
75MAP3K130.82255165
76PRKAA20.81141344
77EEF2K0.80942267
78YES10.80311055
79STK240.79608810
80KSR10.78696293
81CAMK1G0.76332548
82CSF1R0.75730769
83STK100.75720854
84MATK0.75140428
85SGK30.74440083
86CDK60.73655449
87JAK10.72727122
88MAP3K50.72685420
89MST40.72405004
90MAP3K80.72277463
91MAP2K20.70609510
92GRK70.69974825
93NEK90.69172350
94MAPKAPK50.66855492
95LYN0.65882420
96IRAK20.64333107
97CDC42BPA0.64194789
98MST1R0.62916533
99IRAK10.62468637
100MOS0.60094091
101PDPK10.59789429
102PDGFRB0.59477981
103IGF1R0.59287612
104MAPK120.58926765
105DMPK0.58308086
106PAK40.58275182
107MAPKAPK30.58078702
108LCK0.57437715
109RET0.56884310
110WNK40.56368756
111ZAP700.55173146
112CAMKK20.54565370
113FGFR40.54386244
114CSK0.53404716
115HCK0.53109597
116EIF2AK20.53060177
117FGR0.53017104
118ABL10.52576573
119SYK0.52385398
120MAPK110.51977624
121LATS10.50916938
122SGK20.50441501
123WNK10.50102360
124FER0.49676020
125TNIK0.48308822
126MTOR0.47198727
127FGFR30.47000525
128DYRK1B0.45954898
129LRRK20.45579537
130MKNK20.44912941
131TTN0.44845884
132PBK0.44784627
133MAP2K10.44189339
134MELK0.44171136
135MARK30.43438314
136MAP3K60.42940324
137PIK3CA0.42084437
138RIPK10.41986304
139PRKCE0.40704035
140EGFR0.37204809
141STK30.36322256
142PRKD20.34554790
143GSK3A0.32991181
144PRKCH0.31465862
145PDK10.31174915
146PRKCQ0.29695923
147PRKD10.29117516
148RPS6KA50.28673175

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046722.55609429
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.54266531
3Hematopoietic cell lineage_Homo sapiens_hsa046402.24860027
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.21776202
5Leishmaniasis_Homo sapiens_hsa051402.16090816
6Rheumatoid arthritis_Homo sapiens_hsa053232.06214111
7Asthma_Homo sapiens_hsa053102.05670791
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.05381893
9Leukocyte transendothelial migration_Homo sapiens_hsa046701.99641581
10Allograft rejection_Homo sapiens_hsa053301.98871393
11Lysosome_Homo sapiens_hsa041421.93321796
12ABC transporters_Homo sapiens_hsa020101.89505306
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.86011616
14Measles_Homo sapiens_hsa051621.81766110
15Osteoclast differentiation_Homo sapiens_hsa043801.78819759
16Malaria_Homo sapiens_hsa051441.73481983
17Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.69441037
18* Sphingolipid metabolism_Homo sapiens_hsa006001.68157697
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.66013269
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.64204170
21Pertussis_Homo sapiens_hsa051331.63287156
22Adherens junction_Homo sapiens_hsa045201.59822243
23Platelet activation_Homo sapiens_hsa046111.58150974
24Vitamin digestion and absorption_Homo sapiens_hsa049771.54788751
25Transcriptional misregulation in cancer_Homo sapiens_hsa052021.52283857
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.52041017
27African trypanosomiasis_Homo sapiens_hsa051431.45279837
28Toxoplasmosis_Homo sapiens_hsa051451.42718825
29B cell receptor signaling pathway_Homo sapiens_hsa046621.37381658
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36786688
31TNF signaling pathway_Homo sapiens_hsa046681.35981091
32Legionellosis_Homo sapiens_hsa051341.30192726
33ECM-receptor interaction_Homo sapiens_hsa045121.27364384
34Pancreatic cancer_Homo sapiens_hsa052121.26993757
35Staphylococcus aureus infection_Homo sapiens_hsa051501.26747868
36Ovarian steroidogenesis_Homo sapiens_hsa049131.26624053
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26385325
38Renal cell carcinoma_Homo sapiens_hsa052111.21651045
39Complement and coagulation cascades_Homo sapiens_hsa046101.20490390
40Autoimmune thyroid disease_Homo sapiens_hsa053201.20063684
41Prion diseases_Homo sapiens_hsa050201.17693745
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16364630
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.14565692
44Non-small cell lung cancer_Homo sapiens_hsa052231.11148042
45Bladder cancer_Homo sapiens_hsa052191.10150547
46Mineral absorption_Homo sapiens_hsa049781.06311186
47Herpes simplex infection_Homo sapiens_hsa051681.05811825
48HIF-1 signaling pathway_Homo sapiens_hsa040661.05794334
49Influenza A_Homo sapiens_hsa051641.05554751
50Sulfur metabolism_Homo sapiens_hsa009201.05317486
51Primary immunodeficiency_Homo sapiens_hsa053401.01115086
52Hepatitis C_Homo sapiens_hsa051600.98567039
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98460474
54Focal adhesion_Homo sapiens_hsa045100.97928151
55Thyroid cancer_Homo sapiens_hsa052160.97799713
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97629777
57Salmonella infection_Homo sapiens_hsa051320.96927691
58Shigellosis_Homo sapiens_hsa051310.95842612
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95658816
60Tuberculosis_Homo sapiens_hsa051520.93493568
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90535759
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90366841
63Prolactin signaling pathway_Homo sapiens_hsa049170.90093521
64Small cell lung cancer_Homo sapiens_hsa052220.89627394
65Arachidonic acid metabolism_Homo sapiens_hsa005900.88828979
66Viral myocarditis_Homo sapiens_hsa054160.87769616
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86522165
68Rap1 signaling pathway_Homo sapiens_hsa040150.85627604
69Other glycan degradation_Homo sapiens_hsa005110.85253370
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84595390
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84136515
72Notch signaling pathway_Homo sapiens_hsa043300.83427684
73Prostate cancer_Homo sapiens_hsa052150.83161223
74Viral carcinogenesis_Homo sapiens_hsa052030.82243664
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81961489
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80466448
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79368574
78Graft-versus-host disease_Homo sapiens_hsa053320.78645277
79Dorso-ventral axis formation_Homo sapiens_hsa043200.78016703
80Systemic lupus erythematosus_Homo sapiens_hsa053220.77274351
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76782125
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76758413
83Amoebiasis_Homo sapiens_hsa051460.75895367
84Type I diabetes mellitus_Homo sapiens_hsa049400.75023885
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74886755
86Caffeine metabolism_Homo sapiens_hsa002320.74293933
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73997717
88Apoptosis_Homo sapiens_hsa042100.73337003
89Chemokine signaling pathway_Homo sapiens_hsa040620.72595120
90VEGF signaling pathway_Homo sapiens_hsa043700.71995490
91mTOR signaling pathway_Homo sapiens_hsa041500.68577384
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.67841630
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67362053
94Protein digestion and absorption_Homo sapiens_hsa049740.66933075
95Endometrial cancer_Homo sapiens_hsa052130.65448882
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62892655
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.61755835
98Acute myeloid leukemia_Homo sapiens_hsa052210.61494928
99Hepatitis B_Homo sapiens_hsa051610.60564881
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59225353
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58736197
102Insulin resistance_Homo sapiens_hsa049310.58414964
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58207292
104T cell receptor signaling pathway_Homo sapiens_hsa046600.57629264
105Antigen processing and presentation_Homo sapiens_hsa046120.57473593
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56836745
107Endocytosis_Homo sapiens_hsa041440.56662461
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.56533791
109Glioma_Homo sapiens_hsa052140.55145808
110Fatty acid biosynthesis_Homo sapiens_hsa000610.54060347
111Dilated cardiomyopathy_Homo sapiens_hsa054140.53953149
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53630321
113Proteoglycans in cancer_Homo sapiens_hsa052050.52229513
114Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52178194
115Renin secretion_Homo sapiens_hsa049240.51140998
116* Sphingolipid signaling pathway_Homo sapiens_hsa040710.50930355
117Pathways in cancer_Homo sapiens_hsa052000.50625432
118Linoleic acid metabolism_Homo sapiens_hsa005910.49554915
119Ras signaling pathway_Homo sapiens_hsa040140.49157702
120Phagosome_Homo sapiens_hsa041450.48843951
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.48803941
122Vibrio cholerae infection_Homo sapiens_hsa051100.48629911
123Inositol phosphate metabolism_Homo sapiens_hsa005620.47514492
124Pancreatic secretion_Homo sapiens_hsa049720.46957111
125Insulin signaling pathway_Homo sapiens_hsa049100.46539509
126PPAR signaling pathway_Homo sapiens_hsa033200.46517030
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45957151
128Fanconi anemia pathway_Homo sapiens_hsa034600.42818831
129Ether lipid metabolism_Homo sapiens_hsa005650.42788918
130GnRH signaling pathway_Homo sapiens_hsa049120.42340371
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41718344
132FoxO signaling pathway_Homo sapiens_hsa040680.41173467
133MicroRNAs in cancer_Homo sapiens_hsa052060.40981290
134Chronic myeloid leukemia_Homo sapiens_hsa052200.39717427
135cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39074106

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