SGMS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. The protein encoded by this gene is an enzyme that catalyzes this reaction primarily at the cell membrane. The synthesis is reversible, and this enzyme can catalyze the reaction in either direction. The encoded protein is required for cell growth. Three transcript variants encoding the same protein have been found for this gene. There is evidence for more variants, but the full-length nature of their transcripts has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cartilage development involved in endochondral bone morphogenesis (GO:0060351)9.81375583
2keratan sulfate catabolic process (GO:0042340)8.81314425
3cell aggregation (GO:0098743)8.50330326
4cartilage condensation (GO:0001502)8.50330326
5chondrocyte development (GO:0002063)7.86916144
6positive regulation of extracellular matrix organization (GO:1903055)6.28144230
7protein retention in ER lumen (GO:0006621)5.89819586
8maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.87787761
9notochord development (GO:0030903)5.58731519
10cellular glucuronidation (GO:0052695)5.58430273
11collagen fibril organization (GO:0030199)5.58357551
12negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)5.54351841
13limb bud formation (GO:0060174)5.24079555
14nucleotide-sugar biosynthetic process (GO:0009226)5.14380806
15uronic acid metabolic process (GO:0006063)5.09909902
16glucuronate metabolic process (GO:0019585)5.09909902
17COPII vesicle coating (GO:0048208)5.02423870
18COPI coating of Golgi vesicle (GO:0048205)4.92238852
19Golgi transport vesicle coating (GO:0048200)4.92238852
20cell adhesion mediated by integrin (GO:0033627)4.62569646
21regulation of extracellular matrix disassembly (GO:0010715)4.61741921
22regulation of plasminogen activation (GO:0010755)4.61709050
23hemidesmosome assembly (GO:0031581)4.55177923
24cartilage development (GO:0051216)4.45638424
25proteoglycan metabolic process (GO:0006029)4.39252541
26surfactant homeostasis (GO:0043129)4.38164490
27chondroitin sulfate biosynthetic process (GO:0030206)4.30215406
28embryonic skeletal joint morphogenesis (GO:0060272)4.23224368
29UDP-N-acetylglucosamine metabolic process (GO:0006047)4.11444933
30collagen catabolic process (GO:0030574)4.08865184
31desmosome organization (GO:0002934)4.04610049
32endochondral ossification (GO:0001958)3.99950234
33replacement ossification (GO:0036075)3.99950234
34endothelial cell morphogenesis (GO:0001886)3.95672553
35iron ion import (GO:0097286)3.93244760
36regulation of extracellular matrix organization (GO:1903053)3.91224652
37collagen metabolic process (GO:0032963)3.90568313
38keratan sulfate biosynthetic process (GO:0018146)3.87837728
39multicellular organismal catabolic process (GO:0044243)3.84879288
40negative regulation of complement activation (GO:0045916)3.82037025
41multicellular organismal macromolecule metabolic process (GO:0044259)3.66911354
42positive regulation of chondrocyte differentiation (GO:0032332)3.66794767
43regulation of type B pancreatic cell apoptotic process (GO:2000674)3.63814922
44negative regulation of gluconeogenesis (GO:0045721)3.60533349
45chemical homeostasis within a tissue (GO:0048875)3.59742817
46multicellular organismal metabolic process (GO:0044236)3.59092991
47chondrocyte differentiation (GO:0002062)3.58757340
48sulfur compound catabolic process (GO:0044273)3.56888661
49peptidyl-proline hydroxylation (GO:0019511)3.55941097
50skeletal system development (GO:0001501)3.51862039
51hypotonic response (GO:0006971)3.51841062
52regulation of transforming growth factor beta1 production (GO:0032908)3.49020620
53keratan sulfate metabolic process (GO:0042339)3.48145103
54connective tissue development (GO:0061448)3.41631681
55negative regulation of protein activation cascade (GO:2000258)3.41098425
56skin morphogenesis (GO:0043589)3.39512650
57negative regulation of humoral immune response (GO:0002921)3.36577509
584-hydroxyproline metabolic process (GO:0019471)3.28671471
59membrane raft organization (GO:0031579)3.25760472
60lipopolysaccharide biosynthetic process (GO:0009103)3.21608736
61positive regulation of cartilage development (GO:0061036)3.19916877
62nucleotide-sugar metabolic process (GO:0009225)3.19374945
63extracellular matrix disassembly (GO:0022617)3.16904157
64peptidyl-glutamic acid carboxylation (GO:0017187)3.15909175
65protein carboxylation (GO:0018214)3.15909175
66negative regulation of chemokine production (GO:0032682)3.09654467
67regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.08116978
68triglyceride homeostasis (GO:0070328)3.07721807
69acylglycerol homeostasis (GO:0055090)3.07721807
70protein localization to endosome (GO:0036010)3.07137798
71bundle of His cell to Purkinje myocyte communication (GO:0086069)3.06927824
72positive regulation of hormone biosynthetic process (GO:0046886)3.06388236
73glycoprotein metabolic process (GO:0009100)2.98754703
74endodermal cell differentiation (GO:0035987)2.97724734
75sphingosine metabolic process (GO:0006670)2.94416227
76L-phenylalanine catabolic process (GO:0006559)2.94076299
77erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.94076299
78positive regulation of p38MAPK cascade (GO:1900745)2.93631374
79signal peptide processing (GO:0006465)2.93093354
80activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.86886486
81lipopolysaccharide metabolic process (GO:0008653)2.86870041
82myelin assembly (GO:0032288)2.84425871
83response to gravity (GO:0009629)2.84081611
84wound healing, spreading of epidermal cells (GO:0035313)2.82742968
85disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.80111047
86killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.80111047
87endoplasmic reticulum unfolded protein response (GO:0030968)2.79936032
88glycosaminoglycan catabolic process (GO:0006027)2.79652225
89negative regulation of fatty acid transport (GO:2000192)2.76931183
90endocardial cushion morphogenesis (GO:0003203)2.76848298
91cell-substrate junction assembly (GO:0007044)2.75395910
92cellular response to unfolded protein (GO:0034620)2.74086791
93glycosaminoglycan biosynthetic process (GO:0006024)2.74031204
94smooth muscle tissue development (GO:0048745)2.73945174
95sequestering of extracellular ligand from receptor (GO:0035581)2.73632600
96type B pancreatic cell development (GO:0003323)2.72546650
97positive regulation of nuclease activity (GO:0032075)2.72471200
98epithelial cell-cell adhesion (GO:0090136)2.72228292
99diol metabolic process (GO:0034311)2.70837034
100aminoglycan biosynthetic process (GO:0006023)2.70583524
101regulation of metalloenzyme activity (GO:0048552)2.70403212
102macroautophagy (GO:0016236)2.70239962
103regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.70161264
104negative regulation of smooth muscle cell differentiation (GO:0051151)2.69944900
105protein hydroxylation (GO:0018126)2.68990552
106ER-nucleus signaling pathway (GO:0006984)2.67991300
107aminoglycan catabolic process (GO:0006026)2.67881405
108diterpenoid biosynthetic process (GO:0016102)2.67775929
1093-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.67244367
110purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.67244367
111cellular response to BMP stimulus (GO:0071773)2.66363585
112response to BMP (GO:0071772)2.66363585
113vesicle coating (GO:0006901)2.65094519
114pyrimidine-containing compound transmembrane transport (GO:0072531)2.65078764
115regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.63472002
116regulation of membrane protein ectodomain proteolysis (GO:0051043)2.63404261
117regulation of cholesterol homeostasis (GO:2000188)2.62720792
118positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.62196586
119regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.61999961
120aromatic amino acid family catabolic process (GO:0009074)2.61098609
121interleukin-6-mediated signaling pathway (GO:0070102)2.60407771
122regulation of transforming growth factor beta2 production (GO:0032909)2.59737542
123regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.57871191
124regulation of bone mineralization (GO:0030500)2.57418022
125uterus development (GO:0060065)2.56858924
126sphingoid metabolic process (GO:0046519)2.56594806
127platelet-derived growth factor receptor signaling pathway (GO:0048008)2.56043846
128erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.54747823
129L-phenylalanine metabolic process (GO:0006558)2.54747823
130chondrocyte proliferation (GO:0035988)2.53399198
131cellular response to topologically incorrect protein (GO:0035967)2.51084943
132ER overload response (GO:0006983)2.50976951
133dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.47843726
134regulation of steroid hormone biosynthetic process (GO:0090030)2.47346537
135regulation of water loss via skin (GO:0033561)2.47222598
136negative regulation of anoikis (GO:2000811)2.42817089
137regulation of integrin-mediated signaling pathway (GO:2001044)2.42568104
138mesodermal cell differentiation (GO:0048333)2.40535652
139apoptotic cell clearance (GO:0043277)2.38808971
140import into cell (GO:0098657)2.38544231
141multicellular organismal water homeostasis (GO:0050891)2.38115078
142negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.37819273
143keratinocyte proliferation (GO:0043616)2.37762484
144glomerular epithelial cell development (GO:0072310)2.36174434
145oligosaccharide catabolic process (GO:0009313)2.33936117
146negative regulation of protein localization to plasma membrane (GO:1903077)2.31890141
147intestinal epithelial cell development (GO:0060576)2.31184745
148positive regulation of endothelial cell apoptotic process (GO:2000353)2.28941618
149axonemal dynein complex assembly (GO:0070286)2.27907291
150regulation of transforming growth factor beta production (GO:0071634)2.23557636
151interleukin-1-mediated signaling pathway (GO:0070498)2.22780733
152fibril organization (GO:0097435)2.22667346
153wound healing, spreading of cells (GO:0044319)2.21871459
154positive regulation of osteoblast proliferation (GO:0033690)2.20971088
155* sphingomyelin metabolic process (GO:0006684)2.20234223
156regulation of phospholipase A2 activity (GO:0032429)2.19276207
157barbed-end actin filament capping (GO:0051016)2.18803833
158substrate-dependent cell migration (GO:0006929)2.17867988
159cellular response to vitamin D (GO:0071305)2.16339931
160stress fiber assembly (GO:0043149)2.16268990
161retina vasculature morphogenesis in camera-type eye (GO:0061299)2.14607043
162cytoskeletal anchoring at plasma membrane (GO:0007016)2.14208620
163tight junction assembly (GO:0070830)2.13825776
164water homeostasis (GO:0030104)2.13502943
165regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.10373280
166regulation of p38MAPK cascade (GO:1900744)2.09439637
167peptide catabolic process (GO:0043171)2.09162174
168glycosphingolipid catabolic process (GO:0046479)2.07153073
169regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.06853835
170extracellular fibril organization (GO:0043206)2.06742718
171early endosome to late endosome transport (GO:0045022)2.06535107
172regulation of anoikis (GO:2000209)2.06080635
173glycolipid catabolic process (GO:0019377)2.06065365
174regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.05923181
175O-glycan processing (GO:0016266)2.05545562
176negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.05402214
177establishment of endothelial barrier (GO:0061028)2.04816042
178adhesion of symbiont to host cell (GO:0044650)2.04681469
179virion attachment to host cell (GO:0019062)2.04681469
180cilium or flagellum-dependent cell motility (GO:0001539)2.04351191
181glomerular visceral epithelial cell development (GO:0072015)2.04102211
182positive regulation of transforming growth factor beta production (GO:0071636)2.03663666
183positive regulation of cell junction assembly (GO:1901890)2.03243612
184positive regulation of focal adhesion assembly (GO:0051894)2.03243612

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human7.50387804
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.95164764
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.42000114
4GATA1_22025678_ChIP-Seq_K562_Human4.12763522
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.59770531
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.41875723
7AR_21572438_ChIP-Seq_LNCaP_Human3.10807324
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.10442962
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.74790299
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.69436971
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.40976936
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.38484097
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.32264627
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.29497577
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.28514860
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.27254064
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.21341766
18FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.16584167
19CLOCK_20551151_ChIP-Seq_293T_Human2.06723686
20CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.05752186
21CJUN_26792858_Chip-Seq_BT549_Human2.03554350
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.99752596
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.98620291
24ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.93185901
25SOX2_20726797_ChIP-Seq_SW620_Human1.92753366
26EP300_21415370_ChIP-Seq_HL-1_Mouse1.90158735
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.85129564
28AHR_22903824_ChIP-Seq_MCF-7_Human1.83013396
29NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.82433255
30NRF2_20460467_ChIP-Seq_MEFs_Mouse1.82433255
31TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.76307587
32CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.76082918
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.74657572
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.73683727
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.70049717
36CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.69122641
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.64466380
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.61065142
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.59217801
40SALL4_18804426_ChIP-ChIP_XEN_Mouse1.57859473
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51197749
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48860397
43WT1_19549856_ChIP-ChIP_CCG9911_Human1.48200544
44FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.47203205
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45888340
46JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45115094
47* GATA3_24758297_ChIP-Seq_MCF-7_Human1.44913466
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.42386901
49ARNT_22903824_ChIP-Seq_MCF-7_Human1.42056764
50SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.39617335
51SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.39617335
52TP53_16413492_ChIP-PET_HCT116_Human1.38805706
53VDR_24787735_ChIP-Seq_THP-1_Human1.38769598
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37779851
55EGR1_19032775_ChIP-ChIP_M12_Human1.36358720
56TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35895808
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.35241547
58* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33474332
59GATA2_21666600_ChIP-Seq_HMVEC_Human1.32963327
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29529674
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29509152
62FOXM1_26456572_ChIP-Seq_MCF-7_Human1.28110310
63GATA4_25053715_ChIP-Seq_YYC3_Human1.27274228
64FOXO3_23340844_ChIP-Seq_DLD1_Human1.25654671
65RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25503960
66ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.25244270
67* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.24193806
68* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23027649
69CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22542209
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20349864
71HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18278723
72RXR_22108803_ChIP-Seq_LS180_Human1.15895041
73BRD4_25478319_ChIP-Seq_HGPS_Human1.15118136
74EGR1_19374776_ChIP-ChIP_THP-1_Human1.14871352
75IRF8_27001747_Chip-Seq_BMDM_Mouse1.11099380
76SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11002353
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.09223982
78PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.08535898
79TP53_18474530_ChIP-ChIP_U2OS_Human1.08327106
80* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.07069943
81TCF4_18268006_ChIP-ChIP_LS174T_Human1.06588966
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.05161896
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05118982
84STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.04821909
85FOXA2_19822575_ChIP-Seq_HepG2_Human1.03320540
86AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.02257375
87PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01042112
88HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00883063
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00363469
90FLI1_27457419_Chip-Seq_LIVER_Mouse0.99728323
91NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99013391
92GATA6_25053715_ChIP-Seq_YYC3_Human0.98408652
93STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.97870866
94IRF8_22096565_ChIP-ChIP_GC-B_Human0.97763085
95FOXA1_25552417_ChIP-Seq_VCAP_Human0.97427085
96NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96346500
97CDX2_20551321_ChIP-Seq_CACO-2_Human0.95578474
98FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.95189445
99KLF5_25053715_ChIP-Seq_YYC3_Human0.94426471
100PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94218879
101ATF3_27146783_Chip-Seq_COLON_Human0.92493440
102TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.92402478
103NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90660646
104UBF1/2_26484160_Chip-Seq_HMECs_Human0.90638096
105AR_21909140_ChIP-Seq_LNCAP_Human0.88909884
106P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88579662
107NFE2_27457419_Chip-Seq_LIVER_Mouse0.88399043
108ELK1_22589737_ChIP-Seq_MCF10A_Human0.87927421
109PIAS1_25552417_ChIP-Seq_VCAP_Human0.86526103
110* TP63_23658742_ChIP-Seq_EP156T_Human0.86492595
111BRD4_27068464_Chip-Seq_AML-cells_Mouse0.86184398
112SMAD3_21741376_ChIP-Seq_HESCs_Human0.85444228
113PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85407908
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83394217
115CRX_20693478_ChIP-Seq_RETINA_Mouse0.82547567
116TBX20_22080862_ChIP-Seq_HEART_Mouse0.80792021
117TBX20_22328084_ChIP-Seq_HEART_Mouse0.80792021
118CDX2_22108803_ChIP-Seq_LS180_Human0.80703928
119SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.80169927
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.79366756
121SOX9_24532713_ChIP-Seq_HFSC_Mouse0.79297479
122* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.78129163
123* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76463319
124ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75981530
125ELF5_23300383_ChIP-Seq_T47D_Human0.75104201
126SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.74873552
127* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.74129139
128SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.73205768

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002933_joint_inflammation5.01036059
2MP0004134_abnormal_chest_morphology4.16740950
3MP0002282_abnormal_trachea_morphology4.12049272
4MP0002139_abnormal_hepatobiliary_system3.98912435
5MP0010234_abnormal_vibrissa_follicle3.80170719
6MP0000163_abnormal_cartilage_morphology3.57894400
7MP0005503_abnormal_tendon_morphology3.48530622
8MP0009780_abnormal_chondrocyte_physiolo3.36189299
9MP0010352_gastrointestinal_tract_polyps3.34115288
10MP0003950_abnormal_plasma_membrane3.16712879
11MP0009250_abnormal_appendicular_skeleto3.09040835
12MP0002115_abnormal_skeleton_extremities3.01096268
13MP0002896_abnormal_bone_mineralization2.82211998
14MP0001533_abnormal_skeleton_physiology2.63382177
15MP0003195_calcinosis2.62532257
16MP0003646_muscle_fatigue2.55931294
17MP0005360_urolithiasis2.48373188
18MP0002909_abnormal_adrenal_gland2.47698926
19MP0002113_abnormal_skeleton_development2.43839843
20MP0003191_abnormal_cellular_cholesterol2.42484651
21MP0003283_abnormal_digestive_organ2.37928705
22MP0002089_abnormal_postnatal_growth/wei2.32794479
23MP0001542_abnormal_bone_strength2.21807029
24MP0005390_skeleton_phenotype2.20868664
25MP0010678_abnormal_skin_adnexa2.04614886
26MP0004782_abnormal_surfactant_physiolog2.04594632
27MP0003795_abnormal_bone_structure2.00467906
28MP0008438_abnormal_cutaneous_collagen1.97498750
29MP0005085_abnormal_gallbladder_physiolo1.96875684
30MP0005365_abnormal_bile_salt1.96097259
31MP0009840_abnormal_foam_cell1.94552031
32MP0003123_paternal_imprinting1.92679808
33MP0003436_decreased_susceptibility_to1.91390685
34MP0003806_abnormal_nucleotide_metabolis1.90744812
35MP0005508_abnormal_skeleton_morphology1.90311330
36MP0002138_abnormal_hepatobiliary_system1.84594662
37MP0008004_abnormal_stomach_pH1.84181948
38MP0001299_abnormal_eye_distance/1.83957918
39MP0010368_abnormal_lymphatic_system1.83100998
40MP0003453_abnormal_keratinocyte_physiol1.81814295
41MP0001270_distended_abdomen1.81386179
42MP0002163_abnormal_gland_morphology1.79199580
43MP0000013_abnormal_adipose_tissue1.75532911
44MP0009384_cardiac_valve_regurgitation1.72579167
45MP0000762_abnormal_tongue_morphology1.69314318
46MP0002109_abnormal_limb_morphology1.68885821
47MP0003941_abnormal_skin_development1.65433604
48MP0005257_abnormal_intraocular_pressure1.64575245
49MP0002796_impaired_skin_barrier1.58878408
50MP0003252_abnormal_bile_duct1.52130952
51MP0003828_pulmonary_edema1.51120203
52MP0002877_abnormal_melanocyte_morpholog1.49058112
53MP0002998_abnormal_bone_remodeling1.47738982
54MP0006054_spinal_hemorrhage1.46688260
55MP0005058_abnormal_lysosome_morphology1.40981625
56MP0005165_increased_susceptibility_to1.36985727
57MP0008875_abnormal_xenobiotic_pharmacok1.36515479
58MP0000383_abnormal_hair_follicle1.34256230
59MP0005623_abnormal_meninges_morphology1.34165008
60MP0005379_endocrine/exocrine_gland_phen1.34150683
61MP0003045_fibrosis1.31264033
62MP0000343_altered_response_to1.30822748
63MP0002168_other_aberrant_phenotype1.26250239
64MP0000767_abnormal_smooth_muscle1.22982118
65MP0003566_abnormal_cell_adhesion1.22386003
66MP0001663_abnormal_digestive_system1.20921355
67MP0000003_abnormal_adipose_tissue1.19806445
68MP0002295_abnormal_pulmonary_circulatio1.19503625
69MP0006082_CNS_inflammation1.19268681
70MP0009697_abnormal_copulation1.18895321
71MP0005381_digestive/alimentary_phenotyp1.18698086
72MP0005164_abnormal_response_to1.18333509
73MP0003724_increased_susceptibility_to1.17892892
74MP0001216_abnormal_epidermal_layer1.17070498
75MP0005023_abnormal_wound_healing1.15207146
76MP0005275_abnormal_skin_tensile1.14925084
77MP0004947_skin_inflammation1.14384717
78MP0002332_abnormal_exercise_endurance1.13605780
79MP0005220_abnormal_exocrine_pancreas1.11331131
80MP0004883_abnormal_blood_vessel1.06467265
81MP0004272_abnormal_basement_membrane1.05201362
82MP0002116_abnormal_craniofacial_bone1.05035947
83MP0010386_abnormal_urinary_bladder1.04084781
84MP0003868_abnormal_feces_composition1.03166250
85MP0003705_abnormal_hypodermis_morpholog1.02882801
86MP0003183_abnormal_peptide_metabolism1.01337547
87MP0010329_abnormal_lipoprotein_level0.98556880
88MP0005409_darkened_coat_color0.96688615
89MP0002108_abnormal_muscle_morphology0.96558896
90MP0005595_abnormal_vascular_smooth0.96438586
91MP0005319_abnormal_enzyme/_coenzyme0.95621029
92MP0005332_abnormal_amino_acid0.95620894
93MP0001666_abnormal_nutrient_absorption0.94294749
94MP0003755_abnormal_palate_morphology0.94278998
95MP0004510_myositis0.93968106
96MP0003279_aneurysm0.93784067
97MP0005501_abnormal_skin_physiology0.92583995
98MP0003303_peritoneal_inflammation0.91970280
99MP0009643_abnormal_urine_homeostasis0.86951107
100MP0005388_respiratory_system_phenotype0.86776998
101MP0002133_abnormal_respiratory_system0.86776998
102MP0000432_abnormal_head_morphology0.86519000
103MP0003448_altered_tumor_morphology0.86104885
104MP0000462_abnormal_digestive_system0.85930924
105MP0001879_abnormal_lymphatic_vessel0.84164588
106MP0010771_integument_phenotype0.83816674
107MP0000858_altered_metastatic_potential0.81051944
108MP0001851_eye_inflammation0.80801874
109MP0000249_abnormal_blood_vessel0.80416822
110MP0000049_abnormal_middle_ear0.79510986
111MP0005083_abnormal_biliary_tract0.78529359
112MP0005375_adipose_tissue_phenotype0.77559872
113MP0005395_other_phenotype0.77499211
114MP0004019_abnormal_vitamin_homeostasis0.75791424
115MP0001958_emphysema0.75406674
116MP0005166_decreased_susceptibility_to0.74992880
117MP0003787_abnormal_imprinting0.74507598
118MP0005451_abnormal_body_composition0.74311414
119MP0004484_altered_response_of0.73528326
120MP0001765_abnormal_ion_homeostasis0.73455338
121MP0000467_abnormal_esophagus_morphology0.72720877
122MP0000733_abnormal_muscle_development0.72360572
123MP0003186_abnormal_redox_activity0.72179789
124MP0002111_abnormal_tail_morphology0.71851543
125MP0001944_abnormal_pancreas_morphology0.71380189
126MP0001764_abnormal_homeostasis0.70796681
127MP0002006_tumorigenesis0.70382564
128MP0005076_abnormal_cell_differentiation0.69519550
129MP0004084_abnormal_cardiac_muscle0.68536164
130MP0003075_altered_response_to0.67710750
131MP0010155_abnormal_intestine_physiology0.67709425
132MP0004185_abnormal_adipocyte_glucose0.67408657
133MP0003300_gastrointestinal_ulcer0.66704743
134MP0002136_abnormal_kidney_physiology0.66444516
135MP0003935_abnormal_craniofacial_develop0.65967258
136MP0002060_abnormal_skin_morphology0.65670295
137MP0002166_altered_tumor_susceptibility0.65611650
138MP0002971_abnormal_brown_adipose0.65545223
139MP0000627_abnormal_mammary_gland0.64247402
140MP0004043_abnormal_pH_regulation0.64031546
141MP0005636_abnormal_mineral_homeostasis0.62437971
142MP0000465_gastrointestinal_hemorrhage0.62392483
143MP0003091_abnormal_cell_migration0.58223811
144MP0001243_abnormal_dermal_layer0.58170076
145MP0000230_abnormal_systemic_arterial0.57770698
146MP0000538_abnormal_urinary_bladder0.57063468
147* MP0002118_abnormal_lipid_homeostasis0.57002870
148MP0009764_decreased_sensitivity_to0.56227831
149MP0002233_abnormal_nose_morphology0.55751952
150MP0002114_abnormal_axial_skeleton0.55190056
151MP0004264_abnormal_extraembryonic_tissu0.55048255
152MP0004197_abnormal_fetal_growth/weight/0.54916620
153* MP0000609_abnormal_liver_physiology0.54575642
154MP0001756_abnormal_urination0.50429114
155MP0001873_stomach_inflammation0.49742113
156* MP0002419_abnormal_innate_immunity0.48956695

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)9.43200131
2Irregular epiphyses (HP:0010582)8.80643840
3Vitreoretinal degeneration (HP:0000655)7.52363703
4Abnormal tarsal ossification (HP:0008369)6.59263756
5Cupped ribs (HP:0000887)6.51137804
6Hypoplastic ischia (HP:0003175)6.31092036
7Small epiphyses (HP:0010585)6.26029994
8Abnormality of the ischium (HP:0003174)5.65451797
9Flat acetabular roof (HP:0003180)5.33465579
10Delayed epiphyseal ossification (HP:0002663)5.23335895
11Aplasia/Hypoplasia of the pubic bone (HP:0009104)5.21358474
12Flat capital femoral epiphysis (HP:0003370)5.06497228
13Abnormal foot bone ossification (HP:0010675)5.05934371
14Metaphyseal cupping (HP:0003021)5.03742098
15Genu varum (HP:0002970)4.91941070
16Abnormality of the vertebral endplates (HP:0005106)4.47793385
17Abnormality of femoral epiphyses (HP:0006499)4.35897069
18Abnormality involving the epiphyses of the lower limbs (HP:0006500)4.35897069
19Arthropathy (HP:0003040)4.35415006
20Flattened epiphyses (HP:0003071)4.29906945
21Metaphyseal dysplasia (HP:0100255)4.29175744
22Premature rupture of membranes (HP:0001788)4.05998572
23Neonatal short-limb short stature (HP:0008921)4.04893474
24Metaphyseal irregularity (HP:0003025)4.02964150
25Absent epiphyses (HP:0010577)4.00203917
26Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)4.00203917
27Interstitial pulmonary disease (HP:0006530)3.97163229
28Abnormality of the epiphysis of the femoral head (HP:0010574)3.90426042
29Irregular vertebral endplates (HP:0003301)3.89445821
30Osteolytic defects of the phalanges of the hand (HP:0009771)3.88273181
31Osteolytic defects of the hand bones (HP:0009699)3.88273181
32Short femoral neck (HP:0100864)3.85051883
33Osteoarthritis (HP:0002758)3.84072521
34Mild short stature (HP:0003502)3.79299237
35Cardiovascular calcification (HP:0011915)3.74434953
36Protuberant abdomen (HP:0001538)3.66770091
37Protrusio acetabuli (HP:0003179)3.62808490
38Abnormality of the femoral head (HP:0003368)3.60990576
39Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.52969440
40Atrophic scars (HP:0001075)3.41718626
41Right ventricular cardiomyopathy (HP:0011663)3.41450820
42Enlarged epiphyses (HP:0010580)3.40514033
43Vascular calcification (HP:0004934)3.32518961
44Abnormality of carpal bone ossification (HP:0006257)3.28913009
45Coxa vara (HP:0002812)3.27918939
46Arterial tortuosity (HP:0005116)3.26284969
47Aortic aneurysm (HP:0004942)3.26037738
48Vascular tortuosity (HP:0004948)3.25531224
49Aortic dissection (HP:0002647)3.24763581
50Mitral stenosis (HP:0001718)3.22614241
51Ovoid vertebral bodies (HP:0003300)3.18804910
52Thoracolumbar scoliosis (HP:0002944)3.18547475
53Cervical subluxation (HP:0003308)3.18014158
54Beaking of vertebral bodies (HP:0004568)3.14954453
55Platyspondyly (HP:0000926)3.12587202
56Short nail (HP:0001799)3.07204526
57Abnormal vertebral ossification (HP:0100569)3.07026361
58Abnormality of the pubic bones (HP:0003172)2.88179062
59Malnutrition (HP:0004395)2.86610244
60Stillbirth (HP:0003826)2.83838444
61Absent frontal sinuses (HP:0002688)2.82783299
62Abnormality of the proximal phalanges of the hand (HP:0009834)2.81991470
63Aplasia/hypoplasia of the femur (HP:0005613)2.80245148
64Barrel-shaped chest (HP:0001552)2.71935764
65Abnormality of the phalanges of the 2nd finger (HP:0009541)2.68110987
66Waddling gait (HP:0002515)2.67704217
67Vertebral clefting (HP:0008428)2.66497470
68Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.62668599
69Abnormality of glycolipid metabolism (HP:0010969)2.62478849
70Abnormality of liposaccharide metabolism (HP:0010968)2.62478849
71Abnormality of glycosphingolipid metabolism (HP:0004343)2.62478849
72Spondylolisthesis (HP:0003302)2.61411753
73Abnormal hand bone ossification (HP:0010660)2.60903107
74Limited elbow extension (HP:0001377)2.59358149
75Abnormality of the distal phalanges of the toes (HP:0010182)2.56804707
76Abnormality of incisor morphology (HP:0011063)2.55380249
77Abnormal ossification of hand bones (HP:0005921)2.50033996
78Hypoplasia of the odontoid process (HP:0003311)2.48913526
79Tetraparesis (HP:0002273)2.48146323
80Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.44123394
81Fragile skin (HP:0001030)2.43877947
82Alopecia of scalp (HP:0002293)2.43141563
83Wormian bones (HP:0002645)2.42826569
84Thin ribs (HP:0000883)2.42167487
85Abnormality of the lumbar spine (HP:0100712)2.41486692
86Long clavicles (HP:0000890)2.40563151
87Urinary glycosaminoglycan excretion (HP:0003541)2.40171413
88Mucopolysacchariduria (HP:0008155)2.40171413
89Abnormality of the vitreous humor (HP:0004327)2.38173626
90Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.37917254
91Disproportionate short-trunk short stature (HP:0003521)2.37528414
92Vertebral compression fractures (HP:0002953)2.37011213
93Lumbar hyperlordosis (HP:0002938)2.31909356
94Rhinitis (HP:0012384)2.31508140
95Carpal bone hypoplasia (HP:0001498)2.31253740
96Distal lower limb muscle weakness (HP:0009053)2.30772379
97Increased CSF protein (HP:0002922)2.28611838
98Exostoses (HP:0100777)2.27420216
99Abnormality of polysaccharide metabolism (HP:0011012)2.26359116
100Abnormality of glycosaminoglycan metabolism (HP:0004371)2.26359116
101Abnormality of mucopolysaccharide metabolism (HP:0011020)2.26359116
102Limited hip movement (HP:0008800)2.25154720
103Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.25152969
104Striae distensae (HP:0001065)2.23643683
105Fibular hypoplasia (HP:0003038)2.23311633
106Spinal cord compression (HP:0002176)2.23162836
107Hyperactive renin-angiotensin system (HP:0000841)2.22225146
108Follicular hyperkeratosis (HP:0007502)2.21558988
109Overgrowth (HP:0001548)2.19512987
110Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.18078268
111Vertebral hypoplasia (HP:0008417)2.18078268
112Abnormality of monocarboxylic acid metabolism (HP:0010996)2.12303531
113Abnormal respiratory motile cilium physiology (HP:0012261)2.11710418
114Abnormality of the acetabulum (HP:0003170)2.11309215
115Dilatation of the ascending aorta (HP:0005111)2.10566745
116Glossoptosis (HP:0000162)2.08247013
117Fat malabsorption (HP:0002630)2.07482758
118Milia (HP:0001056)2.07326856
119Abnormality of the odontoid process (HP:0003310)2.07232002
120Micromelia (HP:0002983)2.06859304
121Hypoplastic ilia (HP:0000946)2.06653542
122Glucose intolerance (HP:0000833)2.06541033
123Thick nail (HP:0001805)2.05948945
124Reduced subcutaneous adipose tissue (HP:0003758)2.04228008
125Abnormal ciliary motility (HP:0012262)2.03815394
126Hip contracture (HP:0003273)2.03197857
127Radial bowing (HP:0002986)2.03064727
128Steatorrhea (HP:0002570)2.02278394
129Aneurysm (HP:0002617)2.02229979
130Ulnar bowing (HP:0003031)2.01538627
131Hyporeflexia of lower limbs (HP:0002600)1.98816208
132Abnormality of the 2nd finger (HP:0004100)1.97931322
133Onycholysis (HP:0001806)1.96798032
134Dysostosis multiplex (HP:0000943)1.95796850
135Abnormality of the frontal sinuses (HP:0002687)1.95334366
136Subacute progressive viral hepatitis (HP:0006572)1.94719398
137Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.94443432
138Amyloidosis (HP:0011034)1.93970882
139Plantar hyperkeratosis (HP:0007556)1.93952625
140Asymmetric septal hypertrophy (HP:0001670)1.93216307
141Cerebral aneurysm (HP:0004944)1.92497533
142Mesomelia (HP:0003027)1.92348375
143Absent/shortened dynein arms (HP:0200106)1.91323356
144Dynein arm defect of respiratory motile cilia (HP:0012255)1.91323356
145Abnormal glucose tolerance (HP:0001952)1.89310737
146Increased connective tissue (HP:0009025)1.88637082
147Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.88121026
148Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.87803092
149Natal tooth (HP:0000695)1.87676176
150Hypoplasia of dental enamel (HP:0006297)1.87476835
151Myocardial infarction (HP:0001658)1.87044312
152Abnormal cartilage morphology (HP:0002763)1.86809908
153Abdominal distention (HP:0003270)1.84797711
154Conjugated hyperbilirubinemia (HP:0002908)1.84220361
155Abnormality of the nasal mucosa (HP:0000433)1.83929792
156Spinal rigidity (HP:0003306)1.83127440
157Short middle phalanx of finger (HP:0005819)1.82389918
158Coxa valga (HP:0002673)1.80357364
159Chronic bronchitis (HP:0004469)1.79598416
160Flared metaphyses (HP:0003015)1.78673942
161Joint stiffness (HP:0001387)1.78358814
162Popliteal pterygium (HP:0009756)1.77836492
163Intrahepatic cholestasis (HP:0001406)1.76130679
164Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.75730508
165Rhizomelia (HP:0008905)1.75182391
166Hypoplasia of the capital femoral epiphysis (HP:0003090)1.75050122
167Hypoplastic scapulae (HP:0000882)1.74945588
168Aplasia/Hypoplasia of the scapulae (HP:0006713)1.74945588
169Hypoplastic pelvis (HP:0008839)1.74875020
170Abnormality of glutamine family amino acid metabolism (HP:0010902)1.74855768
171Hydroxyprolinuria (HP:0003080)1.73893693
172Abnormality of proline metabolism (HP:0010907)1.73893693
173Periodontitis (HP:0000704)1.73019966
174Mitral valve prolapse (HP:0001634)1.72783261
175Loss of speech (HP:0002371)1.72519733
176Broad phalanx (HP:0006009)1.72203335
177Patent foramen ovale (HP:0001655)1.70920398
178Abnormality of the phalanges of the 5th finger (HP:0004213)1.70659531
179Nuclear cataract (HP:0100018)1.70403770
180Soft skin (HP:0000977)1.70367961
181Tibial bowing (HP:0002982)1.70283185
182Thin bony cortex (HP:0002753)1.69435516
183Hoarse voice (HP:0001609)1.69358248
184Abnormal respiratory motile cilium morphology (HP:0005938)1.69170866
185Abnormal respiratory epithelium morphology (HP:0012253)1.69170866
186Papillary thyroid carcinoma (HP:0002895)1.68506273
187Femoral bowing (HP:0002980)1.66387183
188Skin nodule (HP:0200036)1.64326405
189Hematochezia (HP:0002573)1.62741491
190Ankle contracture (HP:0006466)1.62284905
191Distal lower limb amyotrophy (HP:0008944)1.61963802
192Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.61665593

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K36.56510864
2DDR25.73824588
3STK38L4.48759943
4STK243.86696230
5PRKG23.41987349
6NME13.11328439
7MST42.56154316
8RIPK12.38862323
9LATS12.32841356
10MYLK2.30469653
11ERBB32.16757178
12FRK2.12127345
13NUAK12.06342699
14TAOK31.87380361
15TTN1.73037375
16EIF2AK31.69560602
17STK31.68949991
18MAP3K121.68858926
19TRPM71.66830663
20WNK41.65649160
21TESK11.64566608
22LATS21.62035701
23EPHA21.54586585
24ERN11.51726585
25PDGFRA1.49804937
26INSRR1.44547250
27LMTK21.38259428
28MOS1.37917853
29SIK11.36319962
30STK381.35906143
31MET1.32664954
32PAK41.25033433
33PIM21.24909529
34MST1R1.22197849
35EPHB11.19416170
36PIK3CG1.14098439
37MAP2K31.11243305
38TRIB31.09440098
39MAP3K141.08187380
40WNK31.05347675
41PDGFRB1.04956348
42DMPK0.96573903
43DYRK1A0.95687140
44MAPK150.95195449
45GSK3A0.93509859
46PLK20.93144702
47ARAF0.91848289
48TAOK10.91566918
49CDC42BPA0.91198312
50PDK20.89597620
51MAP3K60.89441790
52PIK3CA0.88064005
53MAP3K130.87374293
54MAP3K90.87215929
55MAP3K10.87019582
56IRAK40.85564114
57AKT30.84399422
58PRKD30.84362382
59BRSK20.82543624
60NEK90.82444672
61MAPK40.80439461
62LIMK10.80019964
63IRAK10.79864786
64PRPF4B0.78537655
65GRK70.77477635
66PTK20.77460864
67EPHA30.72867800
68MKNK20.71864102
69NEK60.70440253
70PAK20.69102774
71FLT30.69036288
72CAMKK20.67182520
73ZAP700.67161039
74FGFR30.64805764
75ERBB40.64339405
76IRAK30.63637396
77TYK20.63529314
78MAPK120.63422148
79NLK0.62314464
80CDK120.61572012
81PBK0.60539106
82BCKDK0.59851824
83ICK0.59757825
84TAOK20.59682053
85MAPK70.59262840
86PTK60.59012401
87ACVR1B0.58922150
88ROCK10.58292375
89SCYL20.57279224
90PDPK10.56935233
91PIM10.56927662
92CSK0.55923730
93WNK10.55702558
94PRKAA20.55579483
95IRAK20.54524041
96FGFR40.53074484
97MTOR0.50646911
98JAK10.48910627
99PASK0.48635592
100TEC0.48502391
101SGK30.47864560
102PRKD20.47771008
103MAPKAPK30.46313633
104KSR20.46061848
105PKN20.45579034
106RPS6KA20.44670493
107EIF2AK10.44192506
108STK100.43913792
109STK390.43722615
110SGK20.43180317
111BCR0.42154561
112PRKCE0.41452069
113YES10.41151313
114RPS6KB10.38641990
115ROCK20.38256743
116TGFBR20.38218117
117MAP3K50.38138947
118MAP2K10.36897680
119CHUK0.36366686
120PRKCD0.35038835
121ABL20.34612534
122PRKACG0.34566596
123MAP3K20.33809766
124EPHB20.33633543
125TBK10.33068790
126MUSK0.31974727
127IGF1R0.31608504
128PTK2B0.31542150
129BMPR1B0.30953362
130LRRK20.30633597
131ABL10.28943306
132NME20.28731069
133FER0.26293812
134BMPR20.25105481
135IKBKB0.24910994
136RPS6KA40.24487633
137MAP3K110.23946536
138MARK30.23768378
139MELK0.23276380
140PRKCI0.23146698
141MAPK30.22568252
142EIF2AK20.21876943
143PRKG10.21446093

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.92527783
2Protein digestion and absorption_Homo sapiens_hsa049744.03076001
3ECM-receptor interaction_Homo sapiens_hsa045123.82723841
4Sulfur metabolism_Homo sapiens_hsa009203.50996508
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.15162898
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.77379941
7Steroid biosynthesis_Homo sapiens_hsa001002.57923209
8Protein export_Homo sapiens_hsa030602.54882015
9Starch and sucrose metabolism_Homo sapiens_hsa005002.52799727
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.28112529
11Selenocompound metabolism_Homo sapiens_hsa004502.24203047
12Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.22636067
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.13685517
14Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.08440659
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.97186107
16Complement and coagulation cascades_Homo sapiens_hsa046101.81591429
17Other glycan degradation_Homo sapiens_hsa005111.74846618
18Nitrogen metabolism_Homo sapiens_hsa009101.71934631
19Adherens junction_Homo sapiens_hsa045201.57711764
20Folate biosynthesis_Homo sapiens_hsa007901.48865274
21Circadian rhythm_Homo sapiens_hsa047101.46858829
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.39700872
23Pertussis_Homo sapiens_hsa051331.38932503
24Arginine biosynthesis_Homo sapiens_hsa002201.37620865
25Tryptophan metabolism_Homo sapiens_hsa003801.37107189
26Focal adhesion_Homo sapiens_hsa045101.32944630
27Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.26880971
28Malaria_Homo sapiens_hsa051441.22100221
29Histidine metabolism_Homo sapiens_hsa003401.18226970
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17321272
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.16180121
32Arginine and proline metabolism_Homo sapiens_hsa003301.16113016
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.15009672
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14531817
35Galactose metabolism_Homo sapiens_hsa000521.14175707
36Vitamin digestion and absorption_Homo sapiens_hsa049771.14010654
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.13069791
38TNF signaling pathway_Homo sapiens_hsa046681.12114063
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10931633
40Dorso-ventral axis formation_Homo sapiens_hsa043201.10458622
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10063333
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08066422
43Staphylococcus aureus infection_Homo sapiens_hsa051501.06121988
44Small cell lung cancer_Homo sapiens_hsa052221.05995013
45Chemical carcinogenesis_Homo sapiens_hsa052041.05664885
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05014464
47* Sphingolipid metabolism_Homo sapiens_hsa006001.00983952
48Salmonella infection_Homo sapiens_hsa051321.00574962
49Hepatitis C_Homo sapiens_hsa051600.98212405
50Toxoplasmosis_Homo sapiens_hsa051450.97642502
51Peroxisome_Homo sapiens_hsa041460.97009671
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96464587
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95465507
54Dilated cardiomyopathy_Homo sapiens_hsa054140.94946748
55Tight junction_Homo sapiens_hsa045300.94705680
56Retinol metabolism_Homo sapiens_hsa008300.93240358
57PI3K-Akt signaling pathway_Homo sapiens_hsa041510.92054707
58Bile secretion_Homo sapiens_hsa049760.91290316
59N-Glycan biosynthesis_Homo sapiens_hsa005100.91173342
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.90461414
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89766043
62Fatty acid degradation_Homo sapiens_hsa000710.88286281
63PPAR signaling pathway_Homo sapiens_hsa033200.86994180
64Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85963335
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83547071
66Glutathione metabolism_Homo sapiens_hsa004800.82998172
67Renal cell carcinoma_Homo sapiens_hsa052110.80946037
68Phagosome_Homo sapiens_hsa041450.80846560
69Legionellosis_Homo sapiens_hsa051340.80413884
70Pancreatic secretion_Homo sapiens_hsa049720.79605327
71TGF-beta signaling pathway_Homo sapiens_hsa043500.77165369
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76232225
73Osteoclast differentiation_Homo sapiens_hsa043800.76062681
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75809949
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75356885
76Butanoate metabolism_Homo sapiens_hsa006500.72108833
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70556777
78Prion diseases_Homo sapiens_hsa050200.70457216
79Phenylalanine metabolism_Homo sapiens_hsa003600.69375027
80Arachidonic acid metabolism_Homo sapiens_hsa005900.69312934
81Fat digestion and absorption_Homo sapiens_hsa049750.69243172
82Pancreatic cancer_Homo sapiens_hsa052120.67510694
83Thyroid hormone synthesis_Homo sapiens_hsa049180.66647573
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.66331261
85Vibrio cholerae infection_Homo sapiens_hsa051100.65605071
86Inositol phosphate metabolism_Homo sapiens_hsa005620.65516434
87African trypanosomiasis_Homo sapiens_hsa051430.65093104
88Lysine degradation_Homo sapiens_hsa003100.64931441
89beta-Alanine metabolism_Homo sapiens_hsa004100.64390068
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63493038
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62822091
92Shigellosis_Homo sapiens_hsa051310.62657810
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.62599296
94Renin secretion_Homo sapiens_hsa049240.61721710
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61137175
96Influenza A_Homo sapiens_hsa051640.60951227
97Tuberculosis_Homo sapiens_hsa051520.60635100
98Rheumatoid arthritis_Homo sapiens_hsa053230.60256922
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59452130
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59429309
101Ovarian steroidogenesis_Homo sapiens_hsa049130.58844861
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.58037879
103* Sphingolipid signaling pathway_Homo sapiens_hsa040710.57116295
104Endocytosis_Homo sapiens_hsa041440.56666573
105Thyroid cancer_Homo sapiens_hsa052160.55558655
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54177062
107FoxO signaling pathway_Homo sapiens_hsa040680.52769323
108Proteoglycans in cancer_Homo sapiens_hsa052050.50477382
109Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50413994
110Propanoate metabolism_Homo sapiens_hsa006400.50233222
111Prostate cancer_Homo sapiens_hsa052150.49869438
112One carbon pool by folate_Homo sapiens_hsa006700.48529819
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48330125
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.47891602
115Chronic myeloid leukemia_Homo sapiens_hsa052200.46882751
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46505470
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45978840
118Caffeine metabolism_Homo sapiens_hsa002320.45463617
119Renin-angiotensin system_Homo sapiens_hsa046140.44110208
120Lysosome_Homo sapiens_hsa041420.43955217
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42749132
122Fatty acid metabolism_Homo sapiens_hsa012120.42394328
123Tyrosine metabolism_Homo sapiens_hsa003500.42354388
124Insulin resistance_Homo sapiens_hsa049310.41798434
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41580553
126ABC transporters_Homo sapiens_hsa020100.41406337
127Pyruvate metabolism_Homo sapiens_hsa006200.38794989
128Mineral absorption_Homo sapiens_hsa049780.36049792
129Leishmaniasis_Homo sapiens_hsa051400.35997726
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34577351
131Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34271246
132Amoebiasis_Homo sapiens_hsa051460.33746950
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33269043
134Fructose and mannose metabolism_Homo sapiens_hsa000510.32905373
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31428869
136Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30138952
137* Metabolic pathways_Homo sapiens_hsa011000.27132282
138Bladder cancer_Homo sapiens_hsa052190.22433290
139Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19189064
140AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.17109900
141Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.16696492
142Pentose phosphate pathway_Homo sapiens_hsa000300.15644209
143Hippo signaling pathway_Homo sapiens_hsa043900.13884808
144Hematopoietic cell lineage_Homo sapiens_hsa046400.12820083
145Olfactory transduction_Homo sapiens_hsa047400.11833298

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