SGO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kinetochore organization (GO:0051383)6.67891591
2mitotic metaphase plate congression (GO:0007080)6.10561685
3metaphase plate congression (GO:0051310)6.08437784
4protein localization to kinetochore (GO:0034501)6.08431333
5mitotic sister chromatid segregation (GO:0000070)6.07926158
6sister chromatid segregation (GO:0000819)5.98959057
7kinetochore assembly (GO:0051382)5.96628409
8CENP-A containing nucleosome assembly (GO:0034080)5.67155208
9regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.61201372
10chromatin remodeling at centromere (GO:0031055)5.60015701
11protein localization to chromosome, centromeric region (GO:0071459)5.43299279
12establishment of chromosome localization (GO:0051303)5.08650519
13mitotic chromosome condensation (GO:0007076)5.08074832
14regulation of spindle organization (GO:0090224)4.89565060
15histone exchange (GO:0043486)4.84069126
16DNA ligation (GO:0006266)4.73913413
17spindle checkpoint (GO:0031577)4.72781155
18regulation of mitotic spindle organization (GO:0060236)4.71371408
19microtubule depolymerization (GO:0007019)4.47996352
20meiotic chromosome segregation (GO:0045132)4.43807823
21negative regulation of chromosome segregation (GO:0051985)4.42421621
22mitotic spindle checkpoint (GO:0071174)4.42211434
23negative regulation of mitotic metaphase/anaphase transition (GO:0045841)4.40855292
24negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.40855292
25negative regulation of mitotic sister chromatid segregation (GO:0033048)4.40855292
26negative regulation of mitotic sister chromatid separation (GO:2000816)4.40855292
27negative regulation of sister chromatid segregation (GO:0033046)4.40855292
28DNA replication-independent nucleosome assembly (GO:0006336)4.35787225
29DNA replication-independent nucleosome organization (GO:0034724)4.35787225
30regulation of chromosome segregation (GO:0051983)4.31168610
31DNA topological change (GO:0006265)4.30772360
32regulation of mitotic metaphase/anaphase transition (GO:0030071)4.26813347
33regulation of metaphase/anaphase transition of cell cycle (GO:1902099)4.26813347
34attachment of spindle microtubules to kinetochore (GO:0008608)4.23277470
35regulation of centriole replication (GO:0046599)4.23120750
36mitotic spindle assembly checkpoint (GO:0007094)4.22985781
37spindle assembly checkpoint (GO:0071173)4.18769995
38regulation of mitotic sister chromatid separation (GO:0010965)4.15434282
39regulation of mitotic sister chromatid segregation (GO:0033047)4.15434282
40regulation of sister chromatid segregation (GO:0033045)4.15434282
41chromosome segregation (GO:0007059)4.06179867
42negative regulation of DNA-dependent DNA replication (GO:2000104)4.04732504
43DNA replication checkpoint (GO:0000076)4.03180410
44protein localization to chromosome (GO:0034502)4.02739359
45regulation of DNA endoreduplication (GO:0032875)3.93941741
46mitotic sister chromatid cohesion (GO:0007064)3.91271149
47replication fork processing (GO:0031297)3.87522563
48resolution of meiotic recombination intermediates (GO:0000712)3.80306917
49regulation of centrosome cycle (GO:0046605)3.79343510
50chromosome condensation (GO:0030261)3.79077531
51synapsis (GO:0007129)3.76439102
52positive regulation of chromosome segregation (GO:0051984)3.76240551
53DNA double-strand break processing (GO:0000729)3.75969477
54centriole replication (GO:0007099)3.70404971
55DNA strand elongation involved in DNA replication (GO:0006271)3.68934376
56mitotic G2/M transition checkpoint (GO:0044818)3.65839054
57DNA unwinding involved in DNA replication (GO:0006268)3.61948389
58mitotic nuclear envelope disassembly (GO:0007077)3.59621190
59protein K6-linked ubiquitination (GO:0085020)3.58509171
60positive regulation of mitotic sister chromatid separation (GO:1901970)3.58281097
61positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.58281097
62positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.58281097
63negative regulation of mitosis (GO:0045839)3.57241009
64telomere maintenance via semi-conservative replication (GO:0032201)3.56681082
65DNA strand elongation (GO:0022616)3.55303506
66mitotic recombination (GO:0006312)3.52039690
67nuclear pore complex assembly (GO:0051292)3.48443993
68regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.47773828
69regulation of mitotic spindle checkpoint (GO:1903504)3.47773828
70maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.42983306
71histone-serine phosphorylation (GO:0035404)3.41633030
72DNA packaging (GO:0006323)3.36936139
73microtubule polymerization or depolymerization (GO:0031109)3.34810621
74nuclear pore organization (GO:0006999)3.30381039
75membrane disassembly (GO:0030397)3.27620679
76nuclear envelope disassembly (GO:0051081)3.27620679
77regulation of centrosome duplication (GO:0010824)3.25182673
78ATP-dependent chromatin remodeling (GO:0043044)3.24725747
79establishment of integrated proviral latency (GO:0075713)3.21872309
80DNA replication-dependent nucleosome assembly (GO:0006335)3.19807310
81DNA replication-dependent nucleosome organization (GO:0034723)3.19807310
82telomere maintenance via recombination (GO:0000722)3.17736745
83ventricular cardiac muscle cell development (GO:0055015)3.17137193
84negative regulation of cell division (GO:0051782)3.14699121
85mitotic G2 DNA damage checkpoint (GO:0007095)3.14581194
86negative regulation of nuclear division (GO:0051784)3.13255491
87anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.09320943
88centrosome organization (GO:0051297)3.08084849
89mitotic cell cycle (GO:0000278)3.06416210
90chromatin assembly or disassembly (GO:0006333)3.06124539
91mitotic spindle organization (GO:0007052)3.04748399
92nucleotide-excision repair, DNA gap filling (GO:0006297)3.03304987
93regulation of double-strand break repair via homologous recombination (GO:0010569)3.02494383
94negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.96406846
95recombinational repair (GO:0000725)2.95845760
96regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.95509811
97spindle assembly involved in mitosis (GO:0090307)2.94856742
98mitotic nuclear division (GO:0007067)2.92765349
99chromosome organization (GO:0051276)2.92586194
100double-strand break repair via homologous recombination (GO:0000724)2.92113227

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human7.96862081
2E2F7_22180533_ChIP-Seq_HELA_Human7.04478041
3E2F4_17652178_ChIP-ChIP_JURKAT_Human5.26842981
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.88877197
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.21433217
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.34573437
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.92422071
8AR_21909140_ChIP-Seq_LNCAP_Human2.88611919
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.84858349
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.75015287
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.74590041
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.42665554
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.40831277
14ELK1_19687146_ChIP-ChIP_HELA_Human2.38945475
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30907208
16KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.28858156
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24353313
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13560519
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.12382839
20EWS_26573619_Chip-Seq_HEK293_Human2.03100139
21ZNF274_21170338_ChIP-Seq_K562_Hela1.99627344
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.92262958
23MYC_19030024_ChIP-ChIP_MESCs_Mouse1.91195778
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88427998
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.86347457
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.83107372
27VDR_23849224_ChIP-Seq_CD4+_Human1.82489559
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.76485205
29MYC_18940864_ChIP-ChIP_HL60_Human1.75525784
30VDR_22108803_ChIP-Seq_LS180_Human1.75197423
31FOXP3_21729870_ChIP-Seq_TREG_Human1.74067283
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71673857
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.67628679
34FUS_26573619_Chip-Seq_HEK293_Human1.65090935
35MYC_18358816_ChIP-ChIP_MESCs_Mouse1.62053240
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.59349772
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59151412
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.56763465
39TTF2_22483619_ChIP-Seq_HELA_Human1.52414572
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49154521
41DCP1A_22483619_ChIP-Seq_HELA_Human1.49121726
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47199794
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.42520099
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40835411
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40310005
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36314871
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.35400865
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30765242
49XRN2_22483619_ChIP-Seq_HELA_Human1.27918890
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20702011
51SOX2_16153702_ChIP-ChIP_HESCs_Human1.20273269
52E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19987459
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19649970
54GABP_19822575_ChIP-Seq_HepG2_Human1.15025186
55NANOG_16153702_ChIP-ChIP_HESCs_Human1.13897714
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13618774
57TAF15_26573619_Chip-Seq_HEK293_Human1.12869613
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12133586
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.11738878
60IRF1_19129219_ChIP-ChIP_H3396_Human1.11025901
61IGF1R_20145208_ChIP-Seq_DFB_Human1.10976919
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.07400533
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07288619
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06753377
65EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.06415785
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.05118509
67ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03446181
68HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03229766
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00738479
70FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99177922
71NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99128550
72P300_19829295_ChIP-Seq_ESCs_Human0.97000461
73KDM5A_27292631_Chip-Seq_BREAST_Human0.96553001
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.95628844
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89913247
76CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84852015
77SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.84739323
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84225813
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.83235445
80ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82849862
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.81208804
82CTBP2_25329375_ChIP-Seq_LNCAP_Human0.80743346
83RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.79190095
84SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.78316360
85CTBP1_25329375_ChIP-Seq_LNCAP_Human0.77298271
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.74483819
87GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.73827291
88FOXM1_26456572_ChIP-Seq_MCF-7_Human0.73608215
89ZFX_18555785_ChIP-Seq_MESCs_Mouse0.71353617
90GATA1_26923725_Chip-Seq_HPCs_Mouse0.71170922
91PCGF2_27294783_Chip-Seq_ESCs_Mouse0.71133458
92SOX17_20123909_ChIP-Seq_XEN_Mouse0.69436563
93PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.69310562
94TP53_22573176_ChIP-Seq_HFKS_Human0.69307459
95YY1_21170310_ChIP-Seq_MESCs_Mouse0.68345913
96EZH2_27294783_Chip-Seq_NPCs_Mouse0.68255266
97SOX9_26525672_Chip-Seq_HEART_Mouse0.67814132
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.66845629
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.65246422
100ELF1_17652178_ChIP-ChIP_JURKAT_Human0.62701113

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.34446540
2MP0003693_abnormal_embryo_hatching4.66091746
3MP0003111_abnormal_nucleus_morphology4.27591572
4MP0008058_abnormal_DNA_repair3.85399089
5MP0003077_abnormal_cell_cycle3.68630034
6MP0004957_abnormal_blastocyst_morpholog3.47276809
7MP0008057_abnormal_DNA_replication3.39283712
8MP0006292_abnormal_olfactory_placode2.95539355
9MP0003718_maternal_effect2.94313097
10MP0008877_abnormal_DNA_methylation2.88604232
11MP0008932_abnormal_embryonic_tissue2.65248412
12MP0008007_abnormal_cellular_replicative2.60394137
13MP0003890_abnormal_embryonic-extraembry2.42454384
14MP0009697_abnormal_copulation2.29031598
15MP0001293_anophthalmia2.06400353
16MP0010307_abnormal_tumor_latency1.88878297
17MP0003937_abnormal_limbs/digits/tail_de1.82911946
18MP0010030_abnormal_orbit_morphology1.78349263
19MP0002938_white_spotting1.76837209
20MP0006072_abnormal_retinal_apoptosis1.63818087
21MP0003786_premature_aging1.58805034
22MP0002210_abnormal_sex_determination1.56530589
23MP0003941_abnormal_skin_development1.52627402
24MP0001929_abnormal_gametogenesis1.51538431
25MP0002234_abnormal_pharynx_morphology1.51364987
26MP0003136_yellow_coat_color1.50811177
27MP0002102_abnormal_ear_morphology1.43929265
28MP0001529_abnormal_vocalization1.43769109
29MP0000350_abnormal_cell_proliferation1.43534672
30MP0001697_abnormal_embryo_size1.39554155
31MP0008789_abnormal_olfactory_epithelium1.39038486
32MP0005380_embryogenesis_phenotype1.33385735
33MP0001672_abnormal_embryogenesis/_devel1.33385735
34MP0002085_abnormal_embryonic_tissue1.33106676
35MP0001286_abnormal_eye_development1.28711661
36MP0003567_abnormal_fetal_cardiomyocyte1.27627690
37MP0001145_abnormal_male_reproductive1.26432569
38MP0003119_abnormal_digestive_system1.25480888
39MP0002084_abnormal_developmental_patter1.25470459
40MP0001730_embryonic_growth_arrest1.22321010
41MP0000653_abnormal_sex_gland1.22163567
42MP0003121_genomic_imprinting1.21846081
43MP0002233_abnormal_nose_morphology1.15536152
44MP0000566_synostosis1.14636321
45MP0000427_abnormal_hair_cycle1.11609081
46MP0000372_irregular_coat_pigmentation1.11170463
47MP0002697_abnormal_eye_size1.07663087
48MP0000049_abnormal_middle_ear1.03028517
49MP0003984_embryonic_growth_retardation1.02788056
50MP0003698_abnormal_male_reproductive1.02647907
51MP0002160_abnormal_reproductive_system1.02329204
52MP0002111_abnormal_tail_morphology1.02158097
53MP0005395_other_phenotype1.02087403
54MP0002088_abnormal_embryonic_growth/wei1.01052679
55MP0002080_prenatal_lethality1.00941677
56MP0001119_abnormal_female_reproductive1.00428701
57MP0005499_abnormal_olfactory_system1.00031651
58MP0005394_taste/olfaction_phenotype1.00031651
59MP0003755_abnormal_palate_morphology0.98723628
60MP0009672_abnormal_birth_weight0.98388739
61MP0004197_abnormal_fetal_growth/weight/0.97822566
62MP0005253_abnormal_eye_physiology0.95447458
63MP0000313_abnormal_cell_death0.95003617
64MP0000647_abnormal_sebaceous_gland0.94679209
65MP0000631_abnormal_neuroendocrine_gland0.93499319
66MP0005391_vision/eye_phenotype0.91940394
67MP0002751_abnormal_autonomic_nervous0.91926010
68MP0003861_abnormal_nervous_system0.88804088
69MP0006035_abnormal_mitochondrial_morpho0.86440180
70MP0001485_abnormal_pinna_reflex0.86149545
71MP0004133_heterotaxia0.83962871
72MP0003195_calcinosis0.83562523
73MP0005389_reproductive_system_phenotype0.81014993
74MP0000428_abnormal_craniofacial_morphol0.80048395
75MP0002161_abnormal_fertility/fecundity0.79374311
76MP0009703_decreased_birth_body0.78143206
77MP0002092_abnormal_eye_morphology0.75633313
78MP0003699_abnormal_female_reproductive0.75335748
79MP0000358_abnormal_cell_content/0.73281557
80MP0005551_abnormal_eye_electrophysiolog0.72983218
81MP0009250_abnormal_appendicular_skeleto0.72007700
82MP0003935_abnormal_craniofacial_develop0.71846456
83MP0004147_increased_porphyrin_level0.69268157
84MP0002396_abnormal_hematopoietic_system0.68871741
85MP0003787_abnormal_imprinting0.68746025
86MP0002019_abnormal_tumor_incidence0.68174630
87MP0003943_abnormal_hepatobiliary_system0.66299021
88MP0003315_abnormal_perineum_morphology0.65663587
89MP0003950_abnormal_plasma_membrane0.64330672
90MP0005195_abnormal_posterior_eye0.63377760
91MP0006036_abnormal_mitochondrial_physio0.63127243
92MP0000432_abnormal_head_morphology0.62934529
93MP0003385_abnormal_body_wall0.62603607
94MP0002282_abnormal_trachea_morphology0.62242112
95MP0002163_abnormal_gland_morphology0.61633603
96MP0002086_abnormal_extraembryonic_tissu0.61174088
97MP0001346_abnormal_lacrimal_gland0.61100417
98MP0002109_abnormal_limb_morphology0.60632457
99MP0004215_abnormal_myocardial_fiber0.60085880
100MP0001177_atelectasis0.59150715

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.11197924
2Chromsome breakage (HP:0040012)4.94798913
3Meckel diverticulum (HP:0002245)4.06650658
4Volvulus (HP:0002580)4.05964858
5Aplasia/Hypoplasia of the uvula (HP:0010293)4.04650741
6Abnormality of chromosome stability (HP:0003220)4.03099138
7Abnormality of the ileum (HP:0001549)3.90743005
8Abnormal lung lobation (HP:0002101)3.63962895
9Duodenal stenosis (HP:0100867)3.57620672
10Small intestinal stenosis (HP:0012848)3.57620672
11Birth length less than 3rd percentile (HP:0003561)3.52673420
12Abnormality of the preputium (HP:0100587)3.49184109
13Abnormality of the labia minora (HP:0012880)3.23038609
14Nephroblastoma (Wilms tumor) (HP:0002667)3.20658827
15Abnormality of the duodenum (HP:0002246)3.18621586
16Increased nuchal translucency (HP:0010880)3.13193781
17Cortical dysplasia (HP:0002539)3.12748231
18Embryonal renal neoplasm (HP:0011794)3.11298483
19Sloping forehead (HP:0000340)3.03557333
20Colon cancer (HP:0003003)2.83746439
21Ectopic kidney (HP:0000086)2.74009004
22Abnormality of the carotid arteries (HP:0005344)2.72340569
23Abnormality of midbrain morphology (HP:0002418)2.67200664
24Molar tooth sign on MRI (HP:0002419)2.67200664
25Triphalangeal thumb (HP:0001199)2.65626184
26Absent radius (HP:0003974)2.63358384
27Supernumerary spleens (HP:0009799)2.63277134
28Myelodysplasia (HP:0002863)2.59430929
29Clubbing of toes (HP:0100760)2.55585451
30Absent forearm bone (HP:0003953)2.54568205
31Aplasia involving forearm bones (HP:0009822)2.54568205
32Pancreatic cysts (HP:0001737)2.53830044
33Pancreatic fibrosis (HP:0100732)2.48953308
34Abnormality of the pons (HP:0007361)2.44717693
35Hypoplasia of the pons (HP:0012110)2.44683494
36Patellar aplasia (HP:0006443)2.44154303
37Oligodactyly (hands) (HP:0001180)2.35239808
38Reticulocytopenia (HP:0001896)2.32155182
39True hermaphroditism (HP:0010459)2.30120726
40Septo-optic dysplasia (HP:0100842)2.26796595
41Aplasia/Hypoplasia of the patella (HP:0006498)2.26730202
42Aplasia/Hypoplasia of the sacrum (HP:0008517)2.18650700
43Small hand (HP:0200055)2.15459610
44Neoplasm of the colon (HP:0100273)2.12579752
45Absent thumb (HP:0009777)2.12573054
46Horseshoe kidney (HP:0000085)2.12293131
47Cerebellar dysplasia (HP:0007033)2.09750926
48Rhabdomyosarcoma (HP:0002859)2.08152251
49Aplasia/Hypoplasia of the sternum (HP:0006714)2.06462028
50Intestinal atresia (HP:0011100)2.02384679
51Dandy-Walker malformation (HP:0001305)2.00926371
52Absent septum pellucidum (HP:0001331)1.96985984
53Preaxial hand polydactyly (HP:0001177)1.96888573
54Short thumb (HP:0009778)1.96559007
55Pendular nystagmus (HP:0012043)1.93277287
56Holoprosencephaly (HP:0001360)1.90870533
57Cafe-au-lait spot (HP:0000957)1.89199833
58Duplicated collecting system (HP:0000081)1.88381265
59Acute necrotizing encephalopathy (HP:0006965)1.88279335
60Nephronophthisis (HP:0000090)1.87507847
61Abnormality of the septum pellucidum (HP:0007375)1.87085034
62Embryonal neoplasm (HP:0002898)1.85354987
63Gastrointestinal atresia (HP:0002589)1.83993443
64Anencephaly (HP:0002323)1.83540124
65Oligodactyly (HP:0012165)1.83256662
66Aplasia/Hypoplasia of the tongue (HP:0010295)1.80869992
67Arteriovenous malformation (HP:0100026)1.79814881
68Hypoplastic pelvis (HP:0008839)1.79547156
69Breast hypoplasia (HP:0003187)1.79388092
70Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77340931
71Acute encephalopathy (HP:0006846)1.76227724
72Increased hepatocellular lipid droplets (HP:0006565)1.72267688
73Choanal atresia (HP:0000453)1.71989478
74Esophageal atresia (HP:0002032)1.71846333
75Sclerocornea (HP:0000647)1.71259770
76Astigmatism (HP:0000483)1.70606028
77Abnormality of the renal collecting system (HP:0004742)1.70093665
78Glioma (HP:0009733)1.69907424
79Carpal bone hypoplasia (HP:0001498)1.69717675
80Type II lissencephaly (HP:0007260)1.68952870
81Oligohydramnios (HP:0001562)1.68834665
82Postaxial foot polydactyly (HP:0001830)1.68342905
83Duplication of thumb phalanx (HP:0009942)1.67519561
84Increased CSF lactate (HP:0002490)1.66502816
85Optic nerve hypoplasia (HP:0000609)1.66014034
86Chronic hepatic failure (HP:0100626)1.65746463
87Ependymoma (HP:0002888)1.64731231
88Aplasia/Hypoplasia of the tibia (HP:0005772)1.64331917
89Abnormality of alanine metabolism (HP:0010916)1.63458257
90Hyperalaninemia (HP:0003348)1.63458257
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.63458257
92Abnormal number of incisors (HP:0011064)1.59807068
93Abnormality of chromosome segregation (HP:0002916)1.59518955
9411 pairs of ribs (HP:0000878)1.59494024
95High pitched voice (HP:0001620)1.59041329
96Abnormality of DNA repair (HP:0003254)1.56693752
97Facial hemangioma (HP:0000329)1.56239258
98Congenital, generalized hypertrichosis (HP:0004540)1.55348531
99Progressive macrocephaly (HP:0004481)1.54807788
100Abnormal mitochondria in muscle tissue (HP:0008316)1.54084011

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.29650712
2WEE13.83241003
3TTK3.74396434
4PLK43.36105256
5NEK13.32264609
6CDC73.16980007
7BRSK22.79576187
8ZAK2.65993626
9PLK32.65640527
10MKNK22.52144631
11PBK2.36391915
12NEK22.33271233
13TSSK62.21110205
14PLK12.13888177
15MKNK12.09321229
16SRPK12.04911567
17PNCK1.91859102
18NUAK11.84251271
19EIF2AK31.70974376
20BMPR1B1.67458153
21WNK31.65459726
22CCNB11.64948369
23VRK21.62708011
24TRIM281.58121454
25VRK11.57856553
26TAF11.52418693
27BRSK11.51892733
28ACVR1B1.51337262
29CHEK21.51181088
30AURKB1.47943054
31TNIK1.38489760
32EIF2AK11.29165114
33ATR1.26400003
34MST41.24072863
35STK31.18933689
36EIF2AK21.17721878
37STK161.00041369
38BRAF0.99918434
39INSRR0.94428849
40TLK10.92970744
41FRK0.92526129
42STK100.88722217
43CHEK10.88454240
44AURKA0.86945635
45WNK40.86322658
46STK390.82042725
47ATM0.81577220
48MAP4K20.78270616
49CDK70.75679765
50MELK0.75240575
51STK40.74472643
52TGFBR10.73995544
53PLK20.72914212
54MAP3K40.68786486
55MARK30.68581056
56ERBB30.65167347
57CDK10.63072588
58MAP3K80.62308768
59PASK0.61482588
60CLK10.55890174
61STK38L0.55749734
62DYRK30.53557811
63MAPK130.50306108
64MAP3K100.47476766
65PRKCI0.45733259
66BRD40.44327960
67CDK20.44155384
68CDK30.43943594
69CASK0.43591189
70CDK80.43271232
71CSNK2A10.43224793
72BCR0.42172311
73GRK10.39610829
74NME10.39170805
75PKN10.38377266
76LATS10.36974686
77OXSR10.36334068
78ADRBK20.35416539
79CSNK2A20.34989504
80ERBB40.33751119
81CDK40.31882462
82CSNK1E0.30348653
83RPS6KA40.30140952
84FGFR10.29802013
85PRKDC0.28695794
86PRKCG0.28467958
87CSNK1G10.26402453
88DYRK20.25757491
89MAP2K70.25031717
90NEK90.22621118
91UHMK10.21724998
92FGFR20.20991566
93MET0.19859777
94CDK180.17829911
95NLK0.15957985
96RPS6KA50.15933551
97CDK150.14530345
98PAK10.13767414
99ALK0.13535603
100FLT30.13527301

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.09074763
2DNA replication_Homo sapiens_hsa030304.00975427
3Homologous recombination_Homo sapiens_hsa034403.98121603
4Fanconi anemia pathway_Homo sapiens_hsa034603.50214395
5Non-homologous end-joining_Homo sapiens_hsa034503.40588357
6Cell cycle_Homo sapiens_hsa041103.29537655
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.96065376
8Proteasome_Homo sapiens_hsa030502.79816289
9Base excision repair_Homo sapiens_hsa034102.64469529
10Nucleotide excision repair_Homo sapiens_hsa034202.59396728
11RNA transport_Homo sapiens_hsa030132.53575243
12Basal transcription factors_Homo sapiens_hsa030222.52520400
13Spliceosome_Homo sapiens_hsa030402.41830994
14RNA polymerase_Homo sapiens_hsa030202.39617029
15RNA degradation_Homo sapiens_hsa030182.23935444
16Protein export_Homo sapiens_hsa030602.21094885
17One carbon pool by folate_Homo sapiens_hsa006702.13943179
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.07963777
19Ribosome_Homo sapiens_hsa030102.03882958
20Pyrimidine metabolism_Homo sapiens_hsa002401.65577447
21Oocyte meiosis_Homo sapiens_hsa041141.65029225
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62650082
23p53 signaling pathway_Homo sapiens_hsa041151.56784132
24Oxidative phosphorylation_Homo sapiens_hsa001901.45674791
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44500682
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.43670743
27Parkinsons disease_Homo sapiens_hsa050121.42614139
28mRNA surveillance pathway_Homo sapiens_hsa030151.42464767
29Selenocompound metabolism_Homo sapiens_hsa004501.39921237
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37239885
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.25194297
32Huntingtons disease_Homo sapiens_hsa050161.25065569
33Steroid biosynthesis_Homo sapiens_hsa001001.22907214
34Propanoate metabolism_Homo sapiens_hsa006401.18594047
35Purine metabolism_Homo sapiens_hsa002301.16741577
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03957511
37Pyruvate metabolism_Homo sapiens_hsa006200.94281625
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87969325
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87920594
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84595226
41Basal cell carcinoma_Homo sapiens_hsa052170.83110531
42Phototransduction_Homo sapiens_hsa047440.81386680
43Folate biosynthesis_Homo sapiens_hsa007900.77958777
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76994842
45Hippo signaling pathway_Homo sapiens_hsa043900.72955676
46Butanoate metabolism_Homo sapiens_hsa006500.71866812
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68623012
48TGF-beta signaling pathway_Homo sapiens_hsa043500.68158475
49Alzheimers disease_Homo sapiens_hsa050100.66711451
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66641171
51Hedgehog signaling pathway_Homo sapiens_hsa043400.66608358
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63336838
53Vitamin B6 metabolism_Homo sapiens_hsa007500.52016606
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50122304
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49374261
56Fatty acid elongation_Homo sapiens_hsa000620.48644436
57Systemic lupus erythematosus_Homo sapiens_hsa053220.48364908
58Wnt signaling pathway_Homo sapiens_hsa043100.46706807
59Metabolic pathways_Homo sapiens_hsa011000.46297926
60Nitrogen metabolism_Homo sapiens_hsa009100.44561060
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.43935441
62Glutathione metabolism_Homo sapiens_hsa004800.43519897
63Lysine degradation_Homo sapiens_hsa003100.43457766
64Alcoholism_Homo sapiens_hsa050340.41878522
65Caffeine metabolism_Homo sapiens_hsa002320.41819782
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41285458
67Epstein-Barr virus infection_Homo sapiens_hsa051690.41219298
68MicroRNAs in cancer_Homo sapiens_hsa052060.38248786
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35321788
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34982686
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34587998
72Biosynthesis of amino acids_Homo sapiens_hsa012300.32943208
73Olfactory transduction_Homo sapiens_hsa047400.32211326
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30856362
75Viral carcinogenesis_Homo sapiens_hsa052030.30706727
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30508369
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28168635
78Cardiac muscle contraction_Homo sapiens_hsa042600.27793150
79Fatty acid metabolism_Homo sapiens_hsa012120.26736127
80Peroxisome_Homo sapiens_hsa041460.25577457
81Tryptophan metabolism_Homo sapiens_hsa003800.24750510
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24414322
83Linoleic acid metabolism_Homo sapiens_hsa005910.23766567
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23683951
85N-Glycan biosynthesis_Homo sapiens_hsa005100.23375434
86Ether lipid metabolism_Homo sapiens_hsa005650.21510822
87Vitamin digestion and absorption_Homo sapiens_hsa049770.21436521
88HTLV-I infection_Homo sapiens_hsa051660.21324307
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20389504
90Sulfur relay system_Homo sapiens_hsa041220.20061011
91Carbon metabolism_Homo sapiens_hsa012000.19447249
92beta-Alanine metabolism_Homo sapiens_hsa004100.19015933
93Colorectal cancer_Homo sapiens_hsa052100.18737942
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.16559959
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.16522950
96Taste transduction_Homo sapiens_hsa047420.14689824
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.14675086
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.13558906
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12524584
100Small cell lung cancer_Homo sapiens_hsa052220.11700679

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