SGPP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 10859351]; Le Stunff et al., 2007 [PubMed 17895250]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)5.38233956
2protein localization to endosome (GO:0036010)4.87632146
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.54334125
4L-phenylalanine catabolic process (GO:0006559)4.54334125
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.15353447
6L-phenylalanine metabolic process (GO:0006558)4.15353447
7cysteine metabolic process (GO:0006534)4.08646869
8B cell receptor signaling pathway (GO:0050853)3.88683162
9regulation of water loss via skin (GO:0033561)3.83558659
10sulfur amino acid catabolic process (GO:0000098)3.79947370
11establishment of skin barrier (GO:0061436)3.76109212
12oligosaccharide catabolic process (GO:0009313)3.75315553
13aromatic amino acid family catabolic process (GO:0009074)3.74796738
14fatty acid elongation (GO:0030497)3.73809458
15antigen processing and presentation of endogenous antigen (GO:0019883)3.62241461
16drug transmembrane transport (GO:0006855)3.59846185
17peptidyl-glutamic acid carboxylation (GO:0017187)3.52415007
18protein carboxylation (GO:0018214)3.52415007
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.48252418
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.48252418
21bile acid biosynthetic process (GO:0006699)3.41021795
22valine metabolic process (GO:0006573)3.38845618
23complement activation, alternative pathway (GO:0006957)3.37751808
24regulation of B cell receptor signaling pathway (GO:0050855)3.33284894
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.32746330
26alpha-linolenic acid metabolic process (GO:0036109)3.32326752
27phospholipid efflux (GO:0033700)3.29885213
28response to phenylpropanoid (GO:0080184)3.26113603
29regulation of phospholipase A2 activity (GO:0032429)3.21758635
30ethanol metabolic process (GO:0006067)3.19081872
31cellular modified amino acid catabolic process (GO:0042219)3.18066743
32urate metabolic process (GO:0046415)3.17658616
33very long-chain fatty acid metabolic process (GO:0000038)3.16748803
34iron ion import (GO:0097286)3.16471617
35glyoxylate metabolic process (GO:0046487)3.13701325
36tryptophan catabolic process (GO:0006569)3.11903529
37indole-containing compound catabolic process (GO:0042436)3.11903529
38indolalkylamine catabolic process (GO:0046218)3.11903529
39tryptophan metabolic process (GO:0006568)3.11785242
40kynurenine metabolic process (GO:0070189)3.10677985
41regulation of protein activation cascade (GO:2000257)3.09960240
42hormone catabolic process (GO:0042447)3.09757819
43lysine catabolic process (GO:0006554)3.09464627
44lysine metabolic process (GO:0006553)3.09464627
45positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.08416428
46regulation of interferon-beta biosynthetic process (GO:0045357)3.08232179
47germinal center formation (GO:0002467)3.07717995
48serine family amino acid catabolic process (GO:0009071)3.06566216
49high-density lipoprotein particle remodeling (GO:0034375)3.04768108
50regulation of T-helper 2 cell differentiation (GO:0045628)3.03705793
51embryonic process involved in female pregnancy (GO:0060136)3.03356596
52Rap protein signal transduction (GO:0032486)3.01864304
53regulation of complement activation (GO:0030449)3.01863188
54urea cycle (GO:0000050)3.01410547
55urea metabolic process (GO:0019627)3.01410547
56cell adhesion mediated by integrin (GO:0033627)2.99722819
57homocysteine metabolic process (GO:0050667)2.99565537
58* sphingoid metabolic process (GO:0046519)2.97052298
59sphingomyelin metabolic process (GO:0006684)2.95271871
60B cell proliferation (GO:0042100)2.93989830
61response to laminar fluid shear stress (GO:0034616)2.92715322
62activation of Rac GTPase activity (GO:0032863)2.91349914
63fatty-acyl-CoA biosynthetic process (GO:0046949)2.90858632
64short-chain fatty acid metabolic process (GO:0046459)2.90855489
65amino-acid betaine metabolic process (GO:0006577)2.88862600
66production of molecular mediator involved in inflammatory response (GO:0002532)2.87349545
67regulation of early endosome to late endosome transport (GO:2000641)2.87059598
68triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.86905145
69multicellular organismal water homeostasis (GO:0050891)2.86823612
70regulation of triglyceride catabolic process (GO:0010896)2.86308641
71nuclear pore complex assembly (GO:0051292)2.86178782
72bile acid metabolic process (GO:0008206)2.86109469
73negative regulation of protein localization to plasma membrane (GO:1903077)2.85736621
74long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.85027661
75NIK/NF-kappaB signaling (GO:0038061)2.84938129
76regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.84222455
77bundle of His cell to Purkinje myocyte communication (GO:0086069)2.83614593
78cell-substrate junction assembly (GO:0007044)2.80917969
79positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.79933380
80negative regulation of lipase activity (GO:0060192)2.79752100
81cytoskeletal anchoring at plasma membrane (GO:0007016)2.79705819
82fatty-acyl-CoA metabolic process (GO:0035337)2.79127503
83primary alcohol catabolic process (GO:0034310)2.78711074
84hypotonic response (GO:0006971)2.77352584
85reverse cholesterol transport (GO:0043691)2.76664426
86regulation of cholesterol homeostasis (GO:2000188)2.76373941
87B cell homeostasis (GO:0001782)2.76166861
88regulation of natural killer cell differentiation (GO:0032823)2.75991867
89water homeostasis (GO:0030104)2.75546882
90drug transport (GO:0015893)2.74075059
91nitrogen cycle metabolic process (GO:0071941)2.73524025
92regulation of transforming growth factor beta1 production (GO:0032908)2.72367443
93tyrosine metabolic process (GO:0006570)2.72247607
94peptide catabolic process (GO:0043171)2.72089625
95aromatic amino acid family metabolic process (GO:0009072)2.72067205
96linoleic acid metabolic process (GO:0043651)2.70211080
97macrophage activation involved in immune response (GO:0002281)2.69936025
98cellular response to thyroid hormone stimulus (GO:0097067)2.68644527
99focal adhesion assembly (GO:0048041)2.67696607
100cell-substrate adherens junction assembly (GO:0007045)2.67696607
101long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.66987863
102imidazole-containing compound metabolic process (GO:0052803)2.66343877
103negative regulation of fibrinolysis (GO:0051918)2.64766554
104keratinization (GO:0031424)2.61867683
105fibrinolysis (GO:0042730)2.61554049
106regulation of cholesterol biosynthetic process (GO:0045540)2.61528037
107glycosphingolipid catabolic process (GO:0046479)2.61217644
108ethanol oxidation (GO:0006069)2.60779918
109sodium-independent organic anion transport (GO:0043252)2.60185330
110negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.60094199
111alpha-amino acid catabolic process (GO:1901606)2.60025645
112positive regulation of sterol transport (GO:0032373)2.59605730
113positive regulation of cholesterol transport (GO:0032376)2.59605730
114positive regulation of gamma-delta T cell activation (GO:0046645)2.59113238
115benzene-containing compound metabolic process (GO:0042537)2.58391524
116regulation of fibrinolysis (GO:0051917)2.57901339
117positive regulation of Rap GTPase activity (GO:0032854)2.57386554
118regulation of type I interferon-mediated signaling pathway (GO:0060338)2.56589962
119cellular amino acid catabolic process (GO:0009063)2.56381750
120thioester biosynthetic process (GO:0035384)2.56202747
121acyl-CoA biosynthetic process (GO:0071616)2.56202747
122Golgi transport vesicle coating (GO:0048200)2.56048336
123COPI coating of Golgi vesicle (GO:0048205)2.56048336
124glutamate metabolic process (GO:0006536)2.55287142
125detection of bacterium (GO:0016045)2.55157703
126fatty acid oxidation (GO:0019395)2.53892209
127membrane raft organization (GO:0031579)2.53876592
128positive regulation of interferon-alpha production (GO:0032727)2.53679738
129antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.53504867
130hemidesmosome assembly (GO:0031581)2.53395702
131acylglycerol homeostasis (GO:0055090)2.52658495
132triglyceride homeostasis (GO:0070328)2.52658495
133lipopolysaccharide-mediated signaling pathway (GO:0031663)2.52568022
134negative regulation of sterol transport (GO:0032372)2.52080113
135negative regulation of cholesterol transport (GO:0032375)2.52080113
136bile acid and bile salt transport (GO:0015721)2.51637055
137cholesterol efflux (GO:0033344)2.51392150
138cortical actin cytoskeleton organization (GO:0030866)2.51069276
139skin morphogenesis (GO:0043589)2.50668944
140regulation of histone H3-K27 methylation (GO:0061085)2.50168199
141response to thyroid hormone (GO:0097066)2.49174632
142response to methylmercury (GO:0051597)2.48422568
143positive regulation of cellular amide metabolic process (GO:0034250)2.47935236
144lipid oxidation (GO:0034440)2.47886897
145immunoglobulin mediated immune response (GO:0016064)2.47777380
146endocytic recycling (GO:0032456)2.47666675
147cellular glucuronidation (GO:0052695)2.47429081
148type I interferon signaling pathway (GO:0060337)2.47016942
149cellular response to type I interferon (GO:0071357)2.47016942
150positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.46398837
151negative regulation of erythrocyte differentiation (GO:0045647)2.45321099
152surfactant homeostasis (GO:0043129)2.43496028
153COPII vesicle coating (GO:0048208)2.42676541
154positive regulation by symbiont of host defense response (GO:0052509)2.41622424
155modulation by symbiont of host defense response (GO:0052031)2.41622424
156modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.41622424
157modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.41622424
158positive regulation by organism of defense response of other organism involved in symbiotic interact2.41622424
159modulation by symbiont of host immune response (GO:0052553)2.41622424
160positive regulation of macrophage cytokine production (GO:0060907)2.39876221
161response to type I interferon (GO:0034340)2.39674235
162retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.38945292
163adherens junction assembly (GO:0034333)2.37539582
164positive regulation of keratinocyte differentiation (GO:0045618)2.36066060
165cellular response to ethanol (GO:0071361)2.35165147
166negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.34865497
167negative regulation of cell killing (GO:0031342)2.34865497
168nuclear pore organization (GO:0006999)2.34393537
169glycolipid catabolic process (GO:0019377)2.33460996
170dicarboxylic acid biosynthetic process (GO:0043650)2.32623337
171regulation of interferon-alpha production (GO:0032647)2.32239676
172gland morphogenesis (GO:0022612)2.31624101
173positive regulation of protein oligomerization (GO:0032461)2.31314461
174interferon-gamma-mediated signaling pathway (GO:0060333)2.31224400
175negative regulation of anoikis (GO:2000811)2.29971955
176detection of molecule of bacterial origin (GO:0032490)2.28717899
177regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.28627757
178chaperone mediated protein folding requiring cofactor (GO:0051085)2.27846697
179negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.27748361
180positive regulation of endothelial cell apoptotic process (GO:2000353)2.27693013
181regulation of transforming growth factor beta2 production (GO:0032909)2.27086362
182myeloid dendritic cell differentiation (GO:0043011)2.26611814
183barbed-end actin filament capping (GO:0051016)2.24156131
184positive regulation of nitric-oxide synthase activity (GO:0051000)2.24149346
185mammary gland epithelial cell proliferation (GO:0033598)2.24141015
186regulation of glucocorticoid metabolic process (GO:0031943)2.22909198
187pinocytosis (GO:0006907)2.22149953
188positive regulation of leukocyte degranulation (GO:0043302)2.21783539
189cellular response to arsenic-containing substance (GO:0071243)2.21638595
190vesicle coating (GO:0006901)2.19864210
191regulation of Rap GTPase activity (GO:0032317)2.19718872
192epithelial cell differentiation involved in prostate gland development (GO:0060742)2.18802478
193regulation of extracellular matrix disassembly (GO:0010715)2.18793109

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.55558043
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.65501497
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.26557562
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.74790436
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.54275305
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.52225299
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.13259819
8MYC_22102868_ChIP-Seq_BL_Human2.93532861
9GATA1_22025678_ChIP-Seq_K562_Human2.77161411
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.74382580
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.67045847
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.60273949
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.32472312
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.30419054
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.30006835
16E2F7_22180533_ChIP-Seq_HELA_Human2.28717739
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.28463290
18FOXO3_23340844_ChIP-Seq_DLD1_Human2.12187430
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.02933264
20CLOCK_20551151_ChIP-Seq_293T_Human2.02189249
21AR_21909140_ChIP-Seq_LNCAP_Human1.99957537
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.99517078
23ZNF263_19887448_ChIP-Seq_K562_Human1.86804261
24P63_26484246_Chip-Seq_KERATINOCYTES_Human1.78082180
25* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.77446185
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.72390402
27SOX9_24532713_ChIP-Seq_HFSC_Mouse1.71628702
28TCF7_22412390_ChIP-Seq_EML_Mouse1.70795442
29* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.69826730
30SOX2_20726797_ChIP-Seq_SW620_Human1.69442091
31CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.69407962
32SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.65660752
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.60570511
34NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.59059376
35GATA4_25053715_ChIP-Seq_YYC3_Human1.56673231
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.56070201
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.55918668
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.54988782
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54451235
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53116543
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52831031
42TFEB_21752829_ChIP-Seq_HELA_Human1.51158328
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.51103687
44IRF8_22096565_ChIP-ChIP_GC-B_Human1.49791814
45FOXM1_23109430_ChIP-Seq_U2OS_Human1.49330345
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48977856
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.47362737
48TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45997394
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45690925
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45113884
51FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.44577395
52VDR_21846776_ChIP-Seq_THP-1_Human1.42937094
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.42794556
54PPAR_26484153_Chip-Seq_NCI-H1993_Human1.37852922
55* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.36712897
56MAF_26560356_Chip-Seq_TH1_Human1.32515480
57* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.32307798
58TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32004018
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31923217
60MYB_26560356_Chip-Seq_TH1_Human1.31489109
61VDR_24763502_ChIP-Seq_THP-1_Human1.31372368
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31018628
63* FOXA2_19822575_ChIP-Seq_HepG2_Human1.30767811
64* PU_27001747_Chip-Seq_BMDM_Mouse1.29411059
65* RUNX1_22412390_ChIP-Seq_EML_Mouse1.29403691
66AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.29071521
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27906635
68UBF1/2_26484160_Chip-Seq_HMECs_Human1.26568119
69* TP63_23658742_ChIP-Seq_EP156T_Human1.26539541
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25475709
71RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24995799
72ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.23249638
73MYB_26560356_Chip-Seq_TH2_Human1.21571828
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21487514
75NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21487514
76CJUN_26792858_Chip-Seq_BT549_Human1.21383604
77P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20204408
78HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19933145
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19320481
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18738861
81SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18660975
82SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18660975
83ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16988943
84EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.16654932
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16607903
86SPI1_23547873_ChIP-Seq_NB4_Human1.15979414
87FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.15692569
88SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.15503405
89PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15441857
90GATA3_24758297_ChIP-Seq_MCF-7_Human1.15212670
91GATA6_25053715_ChIP-Seq_YYC3_Human1.15104538
92* FOXA1_25552417_ChIP-Seq_VCAP_Human1.14957497
93RUNX1_27514584_Chip-Seq_MCF-7_Human1.14718228
94KDM2B_26808549_Chip-Seq_DND41_Human1.13107548
95ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11635045
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11321331
97* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10632120
98DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10446115
99CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09836344
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09232898
101TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08967453
102HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08266030
103TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.07809262
104* IRF8_27001747_Chip-Seq_BMDM_Mouse1.07299635
105* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07125187
106* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07057321
107TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05734766
108SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05450402
109ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05360522
110IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03560752
111* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03312513
112RXR_22108803_ChIP-Seq_LS180_Human1.03238376
113TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02822131
114KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01682023
115ESR1_20079471_ChIP-ChIP_T-47D_Human1.00993290
116TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00498347
117KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99746594
118BRD4_25478319_ChIP-Seq_HGPS_Human0.99698429
119SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99623335
120PIAS1_25552417_ChIP-Seq_VCAP_Human0.98898972
121STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.98708773
122SPI1_23127762_ChIP-Seq_K562_Human0.98545110
123SALL4_18804426_ChIP-ChIP_XEN_Mouse0.98244571
124KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97471239
125RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97342008
126CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97149340
127* BCAT_22108803_ChIP-Seq_LS180_Human0.96452045
128GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96329396
129GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96130819
130STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96126732
131EGR1_19032775_ChIP-ChIP_M12_Human0.94827211
132FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.93995492
133* CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93656643
134NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93302859
135CDX2_20551321_ChIP-Seq_CACO-2_Human0.92773319
136AR_21572438_ChIP-Seq_LNCaP_Human0.91906793
137GATA2_19941826_ChIP-Seq_K562_Human0.89450112
138ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88889677
139RACK7_27058665_Chip-Seq_MCF-7_Human0.88735023
140FOXM1_26456572_ChIP-Seq_MCF-7_Human0.85644959
141GATA2_21666600_ChIP-Seq_HMVEC_Human0.85415271
142* AHR_22903824_ChIP-Seq_MCF-7_Human0.85285404
143BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.82857585
144MYB_21317192_ChIP-Seq_ERMYB_Mouse0.81613291
145TBX20_22080862_ChIP-Seq_HEART_Mouse0.81398827
146TBX20_22328084_ChIP-Seq_HEART_Mouse0.81398827
147VDR_24787735_ChIP-Seq_THP-1_Human0.80665761
148STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.80609177
149* ARNT_22903824_ChIP-Seq_MCF-7_Human0.76582151
150* CDX2_22108803_ChIP-Seq_LS180_Human0.76256584
151GATA1_19941826_ChIP-Seq_K562_Human0.75632972
152* TP53_18474530_ChIP-ChIP_U2OS_Human0.74815494
153HNF4A_19822575_ChIP-Seq_HepG2_Human0.74220728
154* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.72508786
155JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71061738
156ATF3_27146783_Chip-Seq_COLON_Human0.70471909
157TCF4_18268006_ChIP-ChIP_LS174T_Human0.69920696

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.73086523
2MP0010234_abnormal_vibrissa_follicle3.78928482
3MP0002796_impaired_skin_barrier3.76265851
4MP0002139_abnormal_hepatobiliary_system3.70334918
5MP0005360_urolithiasis3.50025518
6MP0005085_abnormal_gallbladder_physiolo2.83600175
7MP0003195_calcinosis2.81149288
8MP0005365_abnormal_bile_salt2.80872048
9MP0004381_abnormal_hair_follicle2.49080521
10MP0005275_abnormal_skin_tensile2.48186706
11MP0008875_abnormal_xenobiotic_pharmacok2.44227248
12MP0005451_abnormal_body_composition2.39102615
13MP0003091_abnormal_cell_migration2.36768693
14MP0008057_abnormal_DNA_replication2.32124879
15MP0010678_abnormal_skin_adnexa2.22517285
16MP0003303_peritoneal_inflammation2.21991274
17MP0003191_abnormal_cellular_cholesterol2.13933704
18MP0003252_abnormal_bile_duct2.11137217
19MP0002060_abnormal_skin_morphology2.06244584
20MP0005501_abnormal_skin_physiology2.03756568
21MP0004947_skin_inflammation2.00507737
22MP0003453_abnormal_keratinocyte_physiol2.00245097
23MP0003300_gastrointestinal_ulcer1.97736572
24MP0003763_abnormal_thymus_physiology1.94633130
25MP0001666_abnormal_nutrient_absorption1.91486990
26MP0002138_abnormal_hepatobiliary_system1.90790173
27MP0001216_abnormal_epidermal_layer1.88563250
28MP0000383_abnormal_hair_follicle1.86637427
29MP0003705_abnormal_hypodermis_morpholog1.86608874
30MP0001800_abnormal_humoral_immune1.79734023
31MP0001346_abnormal_lacrimal_gland1.78256135
32MP0005000_abnormal_immune_tolerance1.77642448
33MP0000579_abnormal_nail_morphology1.77625507
34MP0002009_preneoplasia1.76044494
35MP0005058_abnormal_lysosome_morphology1.74683849
36MP0004019_abnormal_vitamin_homeostasis1.70619979
37MP0005332_abnormal_amino_acid1.68070920
38MP0009840_abnormal_foam_cell1.64141466
39MP0005076_abnormal_cell_differentiation1.62319732
40MP0000377_abnormal_hair_follicle1.61052186
41MP0002452_abnormal_antigen_presenting1.59429503
42MP0002166_altered_tumor_susceptibility1.58641053
43MP0010329_abnormal_lipoprotein_level1.57350210
44MP0002098_abnormal_vibrissa_morphology1.56213223
45MP0002876_abnormal_thyroid_physiology1.52801594
46MP0009643_abnormal_urine_homeostasis1.50555650
47MP0008260_abnormal_autophagy1.48695130
48MP0005310_abnormal_salivary_gland1.48143347
49MP0010386_abnormal_urinary_bladder1.44927067
50MP0010771_integument_phenotype1.43935595
51MP0005623_abnormal_meninges_morphology1.42917428
52MP0003172_abnormal_lysosome_physiology1.41852539
53MP0000647_abnormal_sebaceous_gland1.37501388
54MP0002723_abnormal_immune_serum1.37421299
55MP0001873_stomach_inflammation1.36439956
56MP0005023_abnormal_wound_healing1.33192395
57MP0001851_eye_inflammation1.32796592
58MP0009384_cardiac_valve_regurgitation1.31966746
59MP0002420_abnormal_adaptive_immunity1.31316385
60MP0000685_abnormal_immune_system1.29973090
61MP0000858_altered_metastatic_potential1.29251161
62MP0000609_abnormal_liver_physiology1.28742322
63MP0000427_abnormal_hair_cycle1.28331300
64MP0001819_abnormal_immune_cell1.28026033
65MP0002419_abnormal_innate_immunity1.27254261
66MP0002118_abnormal_lipid_homeostasis1.25560189
67MP0005647_abnormal_sex_gland1.23122351
68MP0003941_abnormal_skin_development1.23081469
69MP0001765_abnormal_ion_homeostasis1.20385256
70MP0000604_amyloidosis1.18613635
71MP0005621_abnormal_cell_physiology1.16865040
72MP0005636_abnormal_mineral_homeostasis1.16610393
73MP0001853_heart_inflammation1.15249386
74MP0003183_abnormal_peptide_metabolism1.14544106
75MP0005083_abnormal_biliary_tract1.14416127
76MP0003436_decreased_susceptibility_to1.12382778
77MP0003448_altered_tumor_morphology1.11956389
78MP0005025_abnormal_response_to1.11189204
79MP0002398_abnormal_bone_marrow1.10592469
80MP0002998_abnormal_bone_remodeling1.08788115
81MP0002877_abnormal_melanocyte_morpholog1.06296806
82MP0000716_abnormal_immune_system1.04641505
83MP0004264_abnormal_extraembryonic_tissu1.04635607
84MP0003279_aneurysm1.04018179
85MP0004185_abnormal_adipocyte_glucose1.03503088
86MP0003690_abnormal_glial_cell1.03350236
87MP0001756_abnormal_urination1.02848593
88MP0004043_abnormal_pH_regulation1.01243607
89MP0004808_abnormal_hematopoietic_stem1.00899565
90MP0002148_abnormal_hypersensitivity_rea1.00837994
91MP0009785_altered_susceptibility_to1.00441731
92MP0001958_emphysema1.00043230
93MP0002006_tumorigenesis0.98806610
94MP0005671_abnormal_response_to0.98757336
95MP0005464_abnormal_platelet_physiology0.98170750
96MP0002405_respiratory_system_inflammati0.97651404
97MP0005220_abnormal_exocrine_pancreas0.97095361
98MP0002396_abnormal_hematopoietic_system0.95939834
99MP0003950_abnormal_plasma_membrane0.95030908
100MP0000538_abnormal_urinary_bladder0.94278377
101MP0003656_abnormal_erythrocyte_physiolo0.93791054
102MP0010307_abnormal_tumor_latency0.93588565
103MP0005319_abnormal_enzyme/_coenzyme0.93573353
104MP0000689_abnormal_spleen_morphology0.93021202
105MP0006082_CNS_inflammation0.92191637
106MP0010352_gastrointestinal_tract_polyps0.91217866
107MP0008004_abnormal_stomach_pH0.90603691
108MP0002136_abnormal_kidney_physiology0.90370698
109MP0009931_abnormal_skin_appearance0.90250179
110MP0001191_abnormal_skin_condition0.89600783
111MP0002429_abnormal_blood_cell0.88754971
112MP0003329_amyloid_beta_deposits0.87088009
113MP0000367_abnormal_coat/_hair0.86914734
114MP0001835_abnormal_antigen_presentation0.86723372
115MP0000537_abnormal_urethra_morphology0.86498004
116MP0003868_abnormal_feces_composition0.86477705
117MP0003828_pulmonary_edema0.86321423
118MP0003075_altered_response_to0.85879136
119MP0005409_darkened_coat_color0.85172818
120MP0003806_abnormal_nucleotide_metabolis0.84961852
121MP0002722_abnormal_immune_system0.84798082
122MP0001533_abnormal_skeleton_physiology0.83186948
123MP0004782_abnormal_surfactant_physiolog0.82883340
124MP0003566_abnormal_cell_adhesion0.82302649
125MP0005164_abnormal_response_to0.81439388
126MP0003045_fibrosis0.81278735
127MP0004272_abnormal_basement_membrane0.81146242
128MP0001243_abnormal_dermal_layer0.81009727
129MP0000465_gastrointestinal_hemorrhage0.79686871
130MP0000920_abnormal_myelination0.78928276
131MP0000003_abnormal_adipose_tissue0.78865202
132MP0009764_decreased_sensitivity_to0.78524446
133MP0005408_hypopigmentation0.77951289
134MP0005584_abnormal_enzyme/coenzyme_acti0.76876383
135MP0005166_decreased_susceptibility_to0.76678922
136MP0000467_abnormal_esophagus_morphology0.76356279
137MP0008469_abnormal_protein_level0.75914411
138MP0004510_myositis0.75017111
139MP0000627_abnormal_mammary_gland0.74550055
140MP0000613_abnormal_salivary_gland0.74522633
141MP0005257_abnormal_intraocular_pressure0.74028461
142MP0005384_cellular_phenotype0.73948940
143MP0001845_abnormal_inflammatory_respons0.73553447
144MP0001881_abnormal_mammary_gland0.73260417
145MP0001790_abnormal_immune_system0.73109873
146MP0005387_immune_system_phenotype0.73109873
147MP0001764_abnormal_homeostasis0.72889882
148MP0003638_abnormal_response/metabolism_0.70739379
149MP0003011_delayed_dark_adaptation0.70207969
150MP0006054_spinal_hemorrhage0.69260334
151MP0002896_abnormal_bone_mineralization0.68660768
152MP0008438_abnormal_cutaneous_collagen0.64788868
153MP0010155_abnormal_intestine_physiology0.64463047
154MP0001348_abnormal_lacrimal_gland0.63559056

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)4.08232221
2Xanthomatosis (HP:0000991)3.98873881
3Gastrointestinal stroma tumor (HP:0100723)3.90415726
4Abnormality of aromatic amino acid family metabolism (HP:0004338)3.77894128
5Deep venous thrombosis (HP:0002625)3.66628868
6Right ventricular cardiomyopathy (HP:0011663)3.62404104
7Complement deficiency (HP:0004431)3.49377404
8Cellulitis (HP:0100658)3.28994112
9Abnormality of monocarboxylic acid metabolism (HP:0010996)3.24121447
10Abnormality of the common coagulation pathway (HP:0010990)3.22519512
11Increased IgE level (HP:0003212)3.19111217
12Prolonged partial thromboplastin time (HP:0003645)3.18370240
13Lip pit (HP:0100267)3.07266959
14Plantar hyperkeratosis (HP:0007556)2.98885802
15Congenital ichthyosiform erythroderma (HP:0007431)2.96098328
16Subacute progressive viral hepatitis (HP:0006572)2.90104863
17Palmoplantar hyperkeratosis (HP:0000972)2.89916181
18Dysostosis multiplex (HP:0000943)2.88656686
19Abnormality of glutamine family amino acid metabolism (HP:0010902)2.87940250
20Epidermoid cyst (HP:0200040)2.86727335
21Fat malabsorption (HP:0002630)2.85367036
22Vacuolated lymphocytes (HP:0001922)2.83770489
23Hyperlipoproteinemia (HP:0010980)2.79430682
24Abnormality of the axillary hair (HP:0100134)2.74474742
25Abnormality of secondary sexual hair (HP:0009888)2.74474742
26Hyperglycinemia (HP:0002154)2.74048305
27Systemic lupus erythematosus (HP:0002725)2.72470910
28Ketosis (HP:0001946)2.72390316
29Abnormality of serine family amino acid metabolism (HP:0010894)2.71664242
30Abnormality of glycine metabolism (HP:0010895)2.71664242
31Viral hepatitis (HP:0006562)2.71310533
32Abnormality of complement system (HP:0005339)2.71189609
33Hyperglycinuria (HP:0003108)2.69714897
34Colitis (HP:0002583)2.69294997
35Osteomyelitis (HP:0002754)2.64839974
36Abnormality of glycolipid metabolism (HP:0010969)2.63506587
37Abnormality of liposaccharide metabolism (HP:0010968)2.63506587
38Abnormality of glycosphingolipid metabolism (HP:0004343)2.63506587
39Parakeratosis (HP:0001036)2.63022867
40Eczematoid dermatitis (HP:0000976)2.60280860
41Hypoglycemic coma (HP:0001325)2.58965462
42Abnormality of macrophages (HP:0004311)2.58660648
43Vertebral compression fractures (HP:0002953)2.57707500
44Palmar hyperkeratosis (HP:0010765)2.56613351
45Agammaglobulinemia (HP:0004432)2.56516371
46Emphysema (HP:0002097)2.55028588
47Abnormality of the intrinsic pathway (HP:0010989)2.54494008
48Arterial tortuosity (HP:0005116)2.52387751
49Abnormality of purine metabolism (HP:0004352)2.52020294
50Myocardial infarction (HP:0001658)2.51848444
51Hypotrichosis (HP:0001006)2.51397144
52Mucopolysacchariduria (HP:0008155)2.50763549
53Urinary glycosaminoglycan excretion (HP:0003541)2.50763549
54Hypobetalipoproteinemia (HP:0003563)2.48512767
55Recurrent bacterial skin infections (HP:0005406)2.47461515
56Woolly hair (HP:0002224)2.46192065
57Gout (HP:0001997)2.46110830
58Mediastinal lymphadenopathy (HP:0100721)2.45251329
59Recurrent viral infections (HP:0004429)2.43016640
60Onycholysis (HP:0001806)2.41428181
61Ketoacidosis (HP:0001993)2.39618225
62Abnormality of nail color (HP:0100643)2.38720025
63Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.37260084
64Type I diabetes mellitus (HP:0100651)2.36801898
65Vascular tortuosity (HP:0004948)2.33561007
66Steatorrhea (HP:0002570)2.32155302
67Recurrent abscess formation (HP:0002722)2.30177807
68Atrophic scars (HP:0001075)2.30136587
69Joint hemorrhage (HP:0005261)2.29502896
70Erythroderma (HP:0001019)2.26394012
71Hyperammonemia (HP:0001987)2.24495026
72Neurofibrillary tangles (HP:0002185)2.22164294
73Vascular calcification (HP:0004934)2.21420199
74Protuberant abdomen (HP:0001538)2.21174087
75Hydroxyprolinuria (HP:0003080)2.21158984
76Abnormality of proline metabolism (HP:0010907)2.21158984
77Lower limb hyperreflexia (HP:0002395)2.19522517
78Conjugated hyperbilirubinemia (HP:0002908)2.18915964
79Abnormality of mucopolysaccharide metabolism (HP:0011020)2.18228519
80Abnormality of polysaccharide metabolism (HP:0011012)2.18228519
81Abnormality of glycosaminoglycan metabolism (HP:0004371)2.18228519
82Abnormality of sulfur amino acid metabolism (HP:0004339)2.17737408
83Hypokalemic alkalosis (HP:0001949)2.16752493
84Glomerulonephritis (HP:0000099)2.15117807
85Osteolytic defects of the phalanges of the hand (HP:0009771)2.11536359
86Osteolytic defects of the hand bones (HP:0009699)2.11536359
87Tetraparesis (HP:0002273)2.11354400
88Premature rupture of membranes (HP:0001788)2.09360873
89Erythema (HP:0010783)2.09173895
90Slow saccadic eye movements (HP:0000514)2.08926200
91Cardiovascular calcification (HP:0011915)2.08003860
92Axonal loss (HP:0003447)2.07360320
93Protrusio acetabuli (HP:0003179)2.06214423
94Sensory axonal neuropathy (HP:0003390)2.06171827
95Flat acetabular roof (HP:0003180)2.05198658
96Gastrointestinal inflammation (HP:0004386)2.04457073
97Hypolipoproteinemia (HP:0010981)2.02982524
98Pancreatitis (HP:0001733)2.00022034
99Hypoplasia of the uterus (HP:0000013)1.99737981
100Meningitis (HP:0001287)1.98289852
101Hyperglycemia (HP:0003074)1.98092426
102Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.97452877
103Hypoalphalipoproteinemia (HP:0003233)1.96344731
104Abnormality of chloride homeostasis (HP:0011422)1.96033311
105Recurrent gram-negative bacterial infections (HP:0005420)1.95078115
106Recurrent bronchitis (HP:0002837)1.92978765
107Inflammation of the large intestine (HP:0002037)1.92747031
108Termporal pattern (HP:0011008)1.92420287
109Insidious onset (HP:0003587)1.92420287
110Abnormality of fatty-acid metabolism (HP:0004359)1.91841731
111Upper motor neuron abnormality (HP:0002127)1.90457175
112Thick nail (HP:0001805)1.90447482
113IgA deficiency (HP:0002720)1.90397114
114Rickets (HP:0002748)1.90031183
115Micronodular cirrhosis (HP:0001413)1.89603270
116Restrictive lung disease (HP:0002091)1.88755159
117Abnormality of aspartate family amino acid metabolism (HP:0010899)1.88642842
118Asymmetry of the thorax (HP:0001555)1.88616848
119Hyporeflexia of lower limbs (HP:0002600)1.87384692
120Conjunctival hamartoma (HP:0100780)1.86303905
121Gingivitis (HP:0000230)1.86246788
122Generalized aminoaciduria (HP:0002909)1.82391360
123Elevated alkaline phosphatase (HP:0003155)1.82330434
124Spinal cord lesions (HP:0100561)1.81933728
125Syringomyelia (HP:0003396)1.81933728
126Pili torti (HP:0003777)1.81495578
127Abnormal enzyme/coenzyme activity (HP:0012379)1.81074806
128Natal tooth (HP:0000695)1.80979196
129Abnormal tarsal ossification (HP:0008369)1.80526037
130Chronic diarrhea (HP:0002028)1.80500280
131Ankyloglossia (HP:0010296)1.79920628
132Hepatitis (HP:0012115)1.79831676
133Abnormality of nucleobase metabolism (HP:0010932)1.79718244
134Fragile nails (HP:0001808)1.79655582
135Abnormality of the gastric mucosa (HP:0004295)1.78688279
136Papilloma (HP:0012740)1.77582623
137Verrucae (HP:0200043)1.77582623
138Nephritis (HP:0000123)1.77568652
139Hypophosphatemic rickets (HP:0004912)1.77026452
140Hypoglycemic seizures (HP:0002173)1.76585200
141Vasculitis (HP:0002633)1.76201806
142Malnutrition (HP:0004395)1.76142355
143Recurrent skin infections (HP:0001581)1.75647631
144Abnormal hemoglobin (HP:0011902)1.75220635
145Abnormal foot bone ossification (HP:0010675)1.73557564
146Cerebral inclusion bodies (HP:0100314)1.73052356
147Pustule (HP:0200039)1.73042569
148Anhidrosis (HP:0000970)1.72976704
149Spontaneous hematomas (HP:0007420)1.72787447
150Coarse hair (HP:0002208)1.72160176
151Bone pain (HP:0002653)1.71874683
152Spinal cord compression (HP:0002176)1.71004302
153Interstitial pulmonary disease (HP:0006530)1.70714977
154Insomnia (HP:0100785)1.70263626
155Apathy (HP:0000741)1.68620037
156Premature loss of primary teeth (HP:0006323)1.68082310
157Scanning speech (HP:0002168)1.67582788
158Ankle contracture (HP:0006466)1.67031958
159Ridged nail (HP:0001807)1.66318082
160Lymphopenia (HP:0001888)1.65999642
161Mitral stenosis (HP:0001718)1.61678382
162Global brain atrophy (HP:0002283)1.61527605
163Bladder carcinoma (HP:0002862)1.60922285
164Bladder neoplasm (HP:0009725)1.60922285
165Alopecia of scalp (HP:0002293)1.59882979
166Transitional cell carcinoma of the bladder (HP:0006740)1.59869107
167Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.59865466
168Overlapping toe (HP:0001845)1.59388678
169Fragile skin (HP:0001030)1.58859306
170Diminished motivation (HP:0000745)1.58848911
171Disinhibition (HP:0000734)1.58795664
172Periodontitis (HP:0000704)1.57344884
173Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.57233170
174Milia (HP:0001056)1.57026068
175Fatigue (HP:0012378)1.55088217
176Dilatation of the ascending aorta (HP:0005111)1.54459642
177Supranuclear gaze palsy (HP:0000605)1.54361584
178Leiomyosarcoma (HP:0100243)1.53511394
179Uterine leiomyosarcoma (HP:0002891)1.53511394
180Abnormality of cells of the lymphoid lineage (HP:0012140)1.53104855
181Thin bony cortex (HP:0002753)1.52489236

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.57922496
2ERN13.27690965
3STK393.06182968
4FRK2.89298167
5MST1R2.85067289
6TAOK32.80287605
7MAP3K132.75921818
8EPHB12.67272759
9MAP3K92.55201559
10MST42.53289869
11FGFR42.43627820
12BCKDK2.40936855
13WNK42.32475129
14MAP3K22.29617483
15LATS12.20031319
16MAP3K32.15930933
17FER1.99495830
18PIK3CG1.96728392
19TYK21.94991191
20OXSR11.93510058
21CDK121.90723355
22EPHA31.90142446
23TRIB31.86058192
24LATS21.85522018
25SMG11.85291235
26BMPR21.85177527
27PTK61.83536889
28ARAF1.64671950
29MAP3K141.64243707
30TNK21.62950813
31INSRR1.61890027
32MAPKAPK51.58624976
33MAP4K11.58561999
34IRAK31.57550689
35LRRK21.56229458
36SIK11.56088614
37CAMKK21.53232536
38MAPK151.49394234
39KSR21.46635332
40ICK1.40300857
41NLK1.37601859
42CSF1R1.32310594
43JAK11.31259633
44MAPKAPK31.27858998
45TRPM71.26457053
46PKN21.25716790
47JAK21.18776376
48ITK1.16995203
49MET1.13174338
50FGFR31.07782219
51MAP3K11.07243930
52FGFR21.06395729
53MELK1.04594681
54SIK30.99932482
55TBK10.99439091
56SCYL20.97695556
57STK100.96852302
58EPHA20.94929452
59MOS0.93741714
60EEF2K0.90555785
61DYRK1B0.90313150
62AKT30.88760948
63MAP3K80.88137126
64BRAF0.88097737
65IRAK10.87886997
66STK30.85515524
67CAMKK10.85070257
68TAOK20.84961648
69TGFBR20.84211963
70MAP2K20.84136173
71HIPK20.84097132
72WNK10.81256360
73STK240.78479442
74SGK30.75644701
75GSK3A0.75202919
76MAP3K120.74849444
77PRKAA20.74308017
78RET0.72826419
79MAP3K70.72639559
80PAK40.69937510
81NEK90.68801590
82JAK30.67973144
83TTN0.65724898
84BRD40.65377225
85BLK0.65268391
86EIF2AK30.65028012
87MAP2K30.64360519
88BTK0.63762056
89TEC0.62933620
90IKBKE0.59970845
91RIPK40.59830388
92YES10.59630358
93RAF10.59333054
94CAMK1D0.58534530
95PTK20.57793549
96IRAK20.56162052
97BMPR1B0.55032138
98KSR10.54138255
99CDK40.54126527
100MAPK120.53527946
101ERBB30.53077980
102PAK20.51654470
103NME20.51168721
104SYK0.50672493
105TAOK10.50531450
106STK40.49985050
107IRAK40.48738289
108MAPK70.48707420
109PDGFRA0.48641385
110CSK0.48279084
111DMPK0.47852102
112WNK30.47707941
113RIPK10.46349762
114MTOR0.46106399
115FGR0.45865462
116PDPK10.45725233
117PRKD10.45261436
118EGFR0.44823209
119RPS6KA40.44413136
120TESK10.44318492
121CDC42BPA0.43067402
122NTRK10.42839988
123CDK60.42289148
124PDK20.42202173
125PAK30.41906977
126ALK0.41824956
127PRKCQ0.41655161
128RPS6KB20.41440083
129CLK10.40801378
130MAP2K10.40323263
131GRK10.39952583
132EIF2AK10.38469877
133MAPK110.38337352
134PDK10.37817052
135FLT30.35362155
136ERBB40.35187001
137IKBKB0.35153642
138ZAP700.34968704
139PDGFRB0.34777686
140IGF1R0.34743188
141ERBB20.34712652
142MAP2K40.33540034
143MAPK40.33415276
144CAMK1G0.30777533
145RPS6KB10.30374988
146MAPKAPK20.30241040
147MAP3K100.29914050

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046623.04922841
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.02516027
3Nitrogen metabolism_Homo sapiens_hsa009102.88254387
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.59430500
5Histidine metabolism_Homo sapiens_hsa003402.52812755
6Sulfur metabolism_Homo sapiens_hsa009202.39262250
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.30001357
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.15016280
9Arginine biosynthesis_Homo sapiens_hsa002202.06698957
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.01764613
11Fatty acid degradation_Homo sapiens_hsa000711.99616142
12Complement and coagulation cascades_Homo sapiens_hsa046101.98610015
13Tryptophan metabolism_Homo sapiens_hsa003801.97940807
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.96320397
15Cyanoamino acid metabolism_Homo sapiens_hsa004601.95250931
16Staphylococcus aureus infection_Homo sapiens_hsa051501.89809610
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.88041046
18Fatty acid elongation_Homo sapiens_hsa000621.86777281
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.79602201
20Caffeine metabolism_Homo sapiens_hsa002321.79483952
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.74081624
22Peroxisome_Homo sapiens_hsa041461.72575267
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.70993174
24Systemic lupus erythematosus_Homo sapiens_hsa053221.68739075
25ABC transporters_Homo sapiens_hsa020101.68019425
26Autoimmune thyroid disease_Homo sapiens_hsa053201.66967649
27Chronic myeloid leukemia_Homo sapiens_hsa052201.66268195
28Allograft rejection_Homo sapiens_hsa053301.61540400
29Phenylalanine metabolism_Homo sapiens_hsa003601.60913617
30Propanoate metabolism_Homo sapiens_hsa006401.59032976
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.58115050
32Chemical carcinogenesis_Homo sapiens_hsa052041.57178293
33Butanoate metabolism_Homo sapiens_hsa006501.55038723
34Non-small cell lung cancer_Homo sapiens_hsa052231.53265341
35Pancreatic cancer_Homo sapiens_hsa052121.52402741
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.50856773
37beta-Alanine metabolism_Homo sapiens_hsa004101.49775826
38PPAR signaling pathway_Homo sapiens_hsa033201.49272668
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.49236276
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.46532912
41Influenza A_Homo sapiens_hsa051641.45580458
42Tuberculosis_Homo sapiens_hsa051521.44005138
43Steroid biosynthesis_Homo sapiens_hsa001001.42709210
44Fatty acid metabolism_Homo sapiens_hsa012121.42328126
45Renal cell carcinoma_Homo sapiens_hsa052111.42143480
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.39310207
47Viral myocarditis_Homo sapiens_hsa054161.39076523
48Retinol metabolism_Homo sapiens_hsa008301.39029349
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38932395
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.37745130
51Small cell lung cancer_Homo sapiens_hsa052221.35829649
52Graft-versus-host disease_Homo sapiens_hsa053321.34858423
53Linoleic acid metabolism_Homo sapiens_hsa005911.30965924
54Vitamin digestion and absorption_Homo sapiens_hsa049771.30369210
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29578697
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28785138
57Tyrosine metabolism_Homo sapiens_hsa003501.27613489
58* Sphingolipid metabolism_Homo sapiens_hsa006001.26923485
59Viral carcinogenesis_Homo sapiens_hsa052031.23472105
60Fat digestion and absorption_Homo sapiens_hsa049751.23286106
61Hepatitis B_Homo sapiens_hsa051611.21857147
62Acute myeloid leukemia_Homo sapiens_hsa052211.20263225
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20114552
64Lysosome_Homo sapiens_hsa041421.20015708
65Endometrial cancer_Homo sapiens_hsa052131.18861471
66Asthma_Homo sapiens_hsa053101.16182569
67Measles_Homo sapiens_hsa051621.14858291
68Herpes simplex infection_Homo sapiens_hsa051681.12802680
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11923840
70Bile secretion_Homo sapiens_hsa049761.11797593
71Proteoglycans in cancer_Homo sapiens_hsa052051.11712694
72TNF signaling pathway_Homo sapiens_hsa046681.10247572
73Long-term potentiation_Homo sapiens_hsa047201.09884109
74Bladder cancer_Homo sapiens_hsa052191.09712726
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.06975699
76Primary immunodeficiency_Homo sapiens_hsa053401.06837232
77Apoptosis_Homo sapiens_hsa042101.04622596
78Thyroid cancer_Homo sapiens_hsa052161.04288746
79Inositol phosphate metabolism_Homo sapiens_hsa005621.03370171
80Central carbon metabolism in cancer_Homo sapiens_hsa052301.03114143
81Type I diabetes mellitus_Homo sapiens_hsa049401.02476966
82VEGF signaling pathway_Homo sapiens_hsa043701.02396031
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.01820203
84* Sphingolipid signaling pathway_Homo sapiens_hsa040711.01012294
85Neurotrophin signaling pathway_Homo sapiens_hsa047221.00974232
86Hematopoietic cell lineage_Homo sapiens_hsa046401.00015007
87Selenocompound metabolism_Homo sapiens_hsa004500.99973724
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99788214
89Starch and sucrose metabolism_Homo sapiens_hsa005000.99148627
90Phagosome_Homo sapiens_hsa041450.98263129
91Glioma_Homo sapiens_hsa052140.97615473
92T cell receptor signaling pathway_Homo sapiens_hsa046600.97442218
93Folate biosynthesis_Homo sapiens_hsa007900.96955044
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95578656
95HTLV-I infection_Homo sapiens_hsa051660.94956170
96Prolactin signaling pathway_Homo sapiens_hsa049170.92381038
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90964400
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90842295
99Other glycan degradation_Homo sapiens_hsa005110.90355729
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90342274
101Focal adhesion_Homo sapiens_hsa045100.88725291
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86425256
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.86161690
104Arachidonic acid metabolism_Homo sapiens_hsa005900.85414245
105MicroRNAs in cancer_Homo sapiens_hsa052060.85046771
106Alcoholism_Homo sapiens_hsa050340.83381521
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81042529
108Protein export_Homo sapiens_hsa030600.80880292
109Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80079617
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79918182
111GnRH signaling pathway_Homo sapiens_hsa049120.78388123
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77455080
113ErbB signaling pathway_Homo sapiens_hsa040120.76965623
114Adherens junction_Homo sapiens_hsa045200.75738459
115Ether lipid metabolism_Homo sapiens_hsa005650.74995402
116Chemokine signaling pathway_Homo sapiens_hsa040620.73451962
117Shigellosis_Homo sapiens_hsa051310.73382996
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.72797329
119Estrogen signaling pathway_Homo sapiens_hsa049150.72729347
120Rheumatoid arthritis_Homo sapiens_hsa053230.71511625
121mTOR signaling pathway_Homo sapiens_hsa041500.71500304
122Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70098340
123Arginine and proline metabolism_Homo sapiens_hsa003300.69438148
124Colorectal cancer_Homo sapiens_hsa052100.69399089
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68437510
126Glutathione metabolism_Homo sapiens_hsa004800.68186323
127FoxO signaling pathway_Homo sapiens_hsa040680.68123293
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.67237237
129Glycerolipid metabolism_Homo sapiens_hsa005610.66532246
130Pyruvate metabolism_Homo sapiens_hsa006200.66502133
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66331832
132Endocytosis_Homo sapiens_hsa041440.65881473
133Platelet activation_Homo sapiens_hsa046110.65345056
134Drug metabolism - other enzymes_Homo sapiens_hsa009830.65116342
135Choline metabolism in cancer_Homo sapiens_hsa052310.64254012
136Fatty acid biosynthesis_Homo sapiens_hsa000610.63506293
137Epstein-Barr virus infection_Homo sapiens_hsa051690.62440315
138Insulin signaling pathway_Homo sapiens_hsa049100.59750543
139Insulin resistance_Homo sapiens_hsa049310.59354391
140Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57860407
141HIF-1 signaling pathway_Homo sapiens_hsa040660.56084730
142Vitamin B6 metabolism_Homo sapiens_hsa007500.54554718
143Pancreatic secretion_Homo sapiens_hsa049720.53673361
144Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52456982
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.49638989
146Legionellosis_Homo sapiens_hsa051340.49503770
147Salmonella infection_Homo sapiens_hsa051320.47648667
148Adipocytokine signaling pathway_Homo sapiens_hsa049200.45807322
149Antigen processing and presentation_Homo sapiens_hsa046120.45056833
150Sulfur relay system_Homo sapiens_hsa041220.43828545
151Amoebiasis_Homo sapiens_hsa051460.43367443
152Protein digestion and absorption_Homo sapiens_hsa049740.40389161
153Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38415713
154Thyroid hormone synthesis_Homo sapiens_hsa049180.36716714
155Hepatitis C_Homo sapiens_hsa051600.36615356
156Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35982215
157Pertussis_Homo sapiens_hsa051330.35650715
158Cysteine and methionine metabolism_Homo sapiens_hsa002700.35558718
159Osteoclast differentiation_Homo sapiens_hsa043800.34880218
160Lysine degradation_Homo sapiens_hsa003100.34315707
161Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32293119
162Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31398437
163Toxoplasmosis_Homo sapiens_hsa051450.30855507
164Dorso-ventral axis formation_Homo sapiens_hsa043200.28459458
1652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.25448030
166Mineral absorption_Homo sapiens_hsa049780.25279115
167Metabolic pathways_Homo sapiens_hsa011000.25174867
168Carbon metabolism_Homo sapiens_hsa012000.24857653
169Prion diseases_Homo sapiens_hsa050200.24631747
170Leukocyte transendothelial migration_Homo sapiens_hsa046700.23658894
171Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.22885262
172Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.22223489
173N-Glycan biosynthesis_Homo sapiens_hsa005100.21534991
174Prostate cancer_Homo sapiens_hsa052150.21332792
175Pentose phosphate pathway_Homo sapiens_hsa000300.20780536
176Leishmaniasis_Homo sapiens_hsa051400.20275488
177NF-kappa B signaling pathway_Homo sapiens_hsa040640.19186582
178ECM-receptor interaction_Homo sapiens_hsa045120.18693820

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »