SGSH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of several enzymes involved in the lysosomal degradation of heparan sulfate. Mutations in this gene are associated with Sanfilippo syndrome A, one type of the lysosomal storage disease mucopolysaccaridosis III, which results from impaired degradation of heparan sulfate. Transcripts of varying sizes have been reported but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.05825527
2embryonic process involved in female pregnancy (GO:0060136)6.47789244
3regulation of integrin activation (GO:0033623)6.35208622
4transcription from mitochondrial promoter (GO:0006390)6.13713768
5proline metabolic process (GO:0006560)5.89526068
6positive regulation of protein homooligomerization (GO:0032464)5.33270843
7replication fork processing (GO:0031297)4.67413758
8cellular response to zinc ion (GO:0071294)4.57130814
9regulation of protein homooligomerization (GO:0032462)4.44770096
10oxidative demethylation (GO:0070989)4.07814151
11DNA deamination (GO:0045006)4.04263839
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.01859300
13negative regulation of cell killing (GO:0031342)4.01859300
14establishment of apical/basal cell polarity (GO:0035089)3.97845826
15embryonic placenta development (GO:0001892)3.90037634
16negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.77586358
17poly(A)+ mRNA export from nucleus (GO:0016973)3.76533937
18positive regulation of protein oligomerization (GO:0032461)3.67409772
19cellular response to ATP (GO:0071318)3.65189286
20maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.64813277
21negative regulation of interleukin-12 production (GO:0032695)3.64724994
22response to peptidoglycan (GO:0032494)3.53720856
23signal complex assembly (GO:0007172)3.51312455
24negative regulation of tumor necrosis factor production (GO:0032720)3.48625017
25mitochondrial DNA metabolic process (GO:0032042)3.47581072
26regulation of interferon-beta biosynthetic process (GO:0045357)3.44829108
27negative regulation of stress fiber assembly (GO:0051497)3.44690784
28negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)3.38159138
29positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.36998080
30mitotic G1 DNA damage checkpoint (GO:0031571)3.34781358
31regulation of macrophage chemotaxis (GO:0010758)3.31676677
32negative regulation of erythrocyte differentiation (GO:0045647)3.28111310
33regulation of B cell receptor signaling pathway (GO:0050855)3.23944444
34apoptotic process involved in morphogenesis (GO:0060561)3.17441281
35establishment of monopolar cell polarity (GO:0061162)3.17138102
36establishment or maintenance of monopolar cell polarity (GO:0061339)3.17138102
37face development (GO:0060324)3.14956314
38regulation of protein oligomerization (GO:0032459)3.14091637
39negative regulation of cell cycle arrest (GO:0071157)3.13993563
40membrane invagination (GO:0010324)3.12906929
41response to muramyl dipeptide (GO:0032495)3.12714067
42positive regulation of T cell apoptotic process (GO:0070234)3.10382075
43response to laminar fluid shear stress (GO:0034616)3.10104359
44glutamine family amino acid biosynthetic process (GO:0009084)3.10047021
45positive regulation of receptor recycling (GO:0001921)3.09732997
46NIK/NF-kappaB signaling (GO:0038061)3.09376424
47negative regulation of protein oligomerization (GO:0032460)3.07437263
48DNA strand renaturation (GO:0000733)3.06812558
49anatomical structure regression (GO:0060033)3.05921515
50modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.05692378
51positive regulation by organism of defense response of other organism involved in symbiotic interact3.05692378
52modulation by symbiont of host immune response (GO:0052553)3.05692378
53positive regulation by symbiont of host defense response (GO:0052509)3.05692378
54modulation by symbiont of host defense response (GO:0052031)3.05692378
55modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.05692378
56apoptotic cell clearance (GO:0043277)3.03854407
57positive regulation of developmental pigmentation (GO:0048087)2.99955531
58macrophage activation involved in immune response (GO:0002281)2.97617460
59regulation of response to reactive oxygen species (GO:1901031)2.97362931
60regulation of podosome assembly (GO:0071801)2.97199285
61regulation of mononuclear cell migration (GO:0071675)2.95805651
62regulation of T-helper 2 cell differentiation (GO:0045628)2.91895971
63neutrophil activation involved in immune response (GO:0002283)2.90303919
64glial cell migration (GO:0008347)2.89559829
65mitotic G1/S transition checkpoint (GO:0044819)2.88146927
66tolerance induction (GO:0002507)2.87981424
67negative regulation of granulocyte differentiation (GO:0030853)2.87800926
68detection of other organism (GO:0098543)2.87186107
69detection of molecule of bacterial origin (GO:0032490)2.86799382
70positive regulation of cell adhesion mediated by integrin (GO:0033630)2.86040230
71protein localization to endosome (GO:0036010)2.83912040
72activation of Rac GTPase activity (GO:0032863)2.83782510
73positive regulation of lymphocyte apoptotic process (GO:0070230)2.83605653
74glycosphingolipid catabolic process (GO:0046479)2.83278436
75negative regulation of fatty acid biosynthetic process (GO:0045717)2.83233378
76negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.80321019
77protein targeting to vacuole (GO:0006623)2.80212026
78protein targeting to lysosome (GO:0006622)2.80212026
79establishment of protein localization to vacuole (GO:0072666)2.80212026
80amino sugar catabolic process (GO:0046348)2.80191400
81detection of bacterium (GO:0016045)2.79956472
82convergent extension (GO:0060026)2.78102754
83mRNA cleavage (GO:0006379)2.77548671
84regulation of translational fidelity (GO:0006450)2.74615753
85negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.74300796
86myeloid dendritic cell differentiation (GO:0043011)2.74157916
87regulation of extracellular matrix disassembly (GO:0010715)2.74152640
88antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.73876916
89antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.73876916
90G1 DNA damage checkpoint (GO:0044783)2.73491929
91negative regulation of JAK-STAT cascade (GO:0046426)2.72063907
92embryonic eye morphogenesis (GO:0048048)2.71880665
93detection of external biotic stimulus (GO:0098581)2.71436592
94base-excision repair (GO:0006284)2.71091590
95regulation of type I interferon-mediated signaling pathway (GO:0060338)2.70973748
96germinal center formation (GO:0002467)2.70779304
97positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.70638947
98embryonic camera-type eye development (GO:0031076)2.69875635
99N-glycan processing (GO:0006491)2.69874730
100leukocyte aggregation (GO:0070486)2.69663292
101sulfur amino acid catabolic process (GO:0000098)2.69101882
102somatic hypermutation of immunoglobulin genes (GO:0016446)2.68403561
103somatic diversification of immune receptors via somatic mutation (GO:0002566)2.68403561
104positive regulation of gamma-delta T cell activation (GO:0046645)2.68189992
105negative regulation of interleukin-8 production (GO:0032717)2.68113359
106positive thymic T cell selection (GO:0045059)2.68099613
107regulation of gamma-delta T cell activation (GO:0046643)2.67638663
108regulation of hydrogen peroxide-induced cell death (GO:1903205)2.67349504
109positive regulation of mast cell activation (GO:0033005)2.67196177
110pinocytosis (GO:0006907)2.66848881
111spliceosomal tri-snRNP complex assembly (GO:0000244)2.66074266
112regulation of T cell tolerance induction (GO:0002664)2.64208202
113leukotriene biosynthetic process (GO:0019370)2.63570037
114positive regulation by host of viral transcription (GO:0043923)2.63389535
115trophectodermal cell differentiation (GO:0001829)2.62726763
116hypotonic response (GO:0006971)2.62056047
117leukocyte cell-cell adhesion (GO:0007159)2.62041507
118negative regulation of interleukin-6 production (GO:0032715)2.61984211
119lipopolysaccharide-mediated signaling pathway (GO:0031663)2.61151094
120regulation of mast cell degranulation (GO:0043304)2.60415037
121mannose metabolic process (GO:0006013)2.59875400
122regulation of dendritic cell antigen processing and presentation (GO:0002604)2.59380201
123antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.59376486
124immunoglobulin mediated immune response (GO:0016064)2.58458752
125thymic T cell selection (GO:0045061)2.58170418
126retinoic acid receptor signaling pathway (GO:0048384)2.57584314
127positive regulation of interferon-beta production (GO:0032728)2.57526388
128negative regulation of response to reactive oxygen species (GO:1901032)2.56508071
129basement membrane organization (GO:0071711)2.56481065
130N-acetylneuraminate metabolic process (GO:0006054)2.56247668
131glycolipid catabolic process (GO:0019377)2.54077909
132negative regulation of viral release from host cell (GO:1902187)2.52963729
133negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.52319821
134regulation of leukocyte degranulation (GO:0043300)2.51599753
135cellular response to interferon-beta (GO:0035458)2.51502768
136amyloid precursor protein catabolic process (GO:0042987)2.51197642
137protein heterotrimerization (GO:0070208)2.50837491
138negative regulation of cytokine production involved in immune response (GO:0002719)2.50172588
139negative regulation of Ras GTPase activity (GO:0034261)2.48867658
140antigen processing and presentation of endogenous antigen (GO:0019883)2.48603781
141negative thymic T cell selection (GO:0045060)2.47242078
142negative regulation of innate immune response (GO:0045824)2.45393090
143T cell selection (GO:0045058)2.44080578
144oligosaccharide catabolic process (GO:0009313)2.42805271
145barbed-end actin filament capping (GO:0051016)2.41710265
146hyaluronan catabolic process (GO:0030214)2.41070628
147granulocyte activation (GO:0036230)2.40394472
148detection of biotic stimulus (GO:0009595)2.39349628
149positive regulation of Cdc42 GTPase activity (GO:0043089)2.39312977
150antigen processing and presentation via MHC class Ib (GO:0002475)2.38541244
151cellular extravasation (GO:0045123)2.38504355
152positive regulation of extracellular matrix organization (GO:1903055)2.37717221
153stress fiber assembly (GO:0043149)2.37223351
154response to type I interferon (GO:0034340)2.36507772
155semaphorin-plexin signaling pathway (GO:0071526)2.35660109
156T-helper 1 type immune response (GO:0042088)2.35320114
157negative T cell selection (GO:0043383)2.34507632
158cellular response to type I interferon (GO:0071357)2.33992151
159type I interferon signaling pathway (GO:0060337)2.33992151
160regulation of myeloid leukocyte mediated immunity (GO:0002886)2.33670408
161positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.33539098
162positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.32828853
163positive regulation of cholesterol efflux (GO:0010875)2.31779391
164peptide catabolic process (GO:0043171)2.31233987
165myeloid dendritic cell activation (GO:0001773)2.31224940
166adhesion of symbiont to host cell (GO:0044650)2.30849067
167virion attachment to host cell (GO:0019062)2.30849067
168regulation of antigen processing and presentation (GO:0002577)2.30488544
169adhesion of symbiont to host (GO:0044406)2.29851053
170regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.29779485
171modulation by symbiont of host cellular process (GO:0044068)2.27812232
172tumor necrosis factor-mediated signaling pathway (GO:0033209)2.27194764
173regulation of mast cell activation involved in immune response (GO:0033006)2.26151660
174regulation of tolerance induction (GO:0002643)2.26057893
175keratan sulfate catabolic process (GO:0042340)2.25748866
176positive regulation of antigen processing and presentation (GO:0002579)2.25225334
177regulation of type 2 immune response (GO:0002828)2.24482733
178neutrophil activation (GO:0042119)2.23131026
179regulation of tumor necrosis factor production (GO:0032680)2.21536041
180positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.21454936
181positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.19490756

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.24743640
2IRF8_22096565_ChIP-ChIP_GC-B_Human2.84442394
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.67153703
4NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.56297544
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.53382234
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.42207867
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.41187851
8MYC_22102868_ChIP-Seq_BL_Human2.31441250
9LXR_22292898_ChIP-Seq_THP-1_Human2.27061732
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.08708279
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.05784855
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.04569399
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.01668402
14TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.97447799
15* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96362988
16SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.94102126
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.91639333
18VDR_24763502_ChIP-Seq_THP-1_Human1.91620125
19ELK3_25401928_ChIP-Seq_HUVEC_Human1.85887650
20* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84437996
21PU.1_20513432_ChIP-Seq_Bcells_Mouse1.84086369
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.83858634
23IRF8_27001747_Chip-Seq_BMDM_Mouse1.83709602
24MAF_26560356_Chip-Seq_TH1_Human1.82773540
25PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.79863738
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.75653564
27ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.74224799
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.71791165
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.71219111
30KDM2B_26808549_Chip-Seq_DND41_Human1.69362450
31SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.68786860
32KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.64815406
33* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.64165648
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62831779
35RACK7_27058665_Chip-Seq_MCF-7_Human1.58677369
36TP63_17297297_ChIP-ChIP_HaCaT_Human1.58542908
37* TCF7_22412390_ChIP-Seq_EML_Mouse1.57426576
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.57274586
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.54182945
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.52880512
41KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.52825457
42KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.52825457
43KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.52825457
44DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.52511811
45CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.51057864
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.50279566
47UTX_26944678_Chip-Seq_JUKART_Human1.49894265
48KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.47841642
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45843051
50* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.45357174
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44636272
52* RUNX1_22412390_ChIP-Seq_EML_Mouse1.44480270
53KDM2B_26808549_Chip-Seq_K562_Human1.43146967
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40675606
55P68_20966046_ChIP-Seq_HELA_Human1.40566592
56SPI1_23547873_ChIP-Seq_NB4_Human1.39567545
57SA1_27219007_Chip-Seq_ERYTHROID_Human1.37432056
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37220812
59RXR_22158963_ChIP-Seq_LIVER_Mouse1.35175558
60SPI1_23127762_ChIP-Seq_K562_Human1.34218045
61RUNX_20019798_ChIP-Seq_JUKART_Human1.32722610
62* TET1_21451524_ChIP-Seq_MESCs_Mouse1.31446795
63MYB_26560356_Chip-Seq_TH1_Human1.30695240
64PPARA_22158963_ChIP-Seq_LIVER_Mouse1.30599885
65SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.30564398
66CDX2_20551321_ChIP-Seq_CACO-2_Human1.26857707
67CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26478786
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26267161
69MAF_26560356_Chip-Seq_TH2_Human1.24451492
70CTCF_21964334_ChIP-Seq_BJAB-B_Human1.24368465
71FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.24117670
72UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23781308
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23632038
74SMC4_20622854_ChIP-Seq_HELA_Human1.23593766
75CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23593315
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.22963279
77CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22570856
78* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21969706
79RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21330667
80FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.20945492
81CTCF_27219007_Chip-Seq_ERYTHROID_Human1.20914095
82TP53_22127205_ChIP-Seq_IMR90_Human1.20869564
83IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.20263678
84NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19760000
85SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19687528
86RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19088438
87GATA1_19941827_ChIP-Seq_MEL_Mouse1.18784326
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.18310097
89POU5F1_16518401_ChIP-PET_MESCs_Mouse1.17672861
90CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16685329
91SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16536599
92MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16470959
93NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16054429
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14959166
95STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.12173822
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12092276
97SPI1_20517297_ChIP-Seq_HL60_Human1.11656379
98CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10950527
99STAT1_20625510_ChIP-Seq_HELA_Human1.10850114
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10794726
101PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10756823
102GATA2_21666600_ChIP-Seq_HMVEC_Human1.10556008
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10134578
104TFEB_21752829_ChIP-Seq_HELA_Human1.10096698
105* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09967647
106BCL6_27268052_Chip-Seq_Bcells_Human1.08897899
107RUNX1_27514584_Chip-Seq_MCF-7_Human1.08400501
108P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07406242
109ESR1_21235772_ChIP-Seq_MCF-7_Human1.07252680
110BCOR_27268052_Chip-Seq_Bcells_Human1.07247621
111GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06662703
112Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06629318
113PU_27001747_Chip-Seq_BMDM_Mouse1.05506168
114SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05085963
115KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05063453
116EGR1_19374776_ChIP-ChIP_THP-1_Human1.04899979
117ETS1_21867929_ChIP-Seq_TH2_Mouse1.04623476
118TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03456832
119CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03332767
120SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03291975
121IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03191206
122SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03142836
123* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02798128
124DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02447101
125P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02250325
126CREB1_26743006_Chip-Seq_LNCaP_Human1.02077336
127KDM2B_26808549_Chip-Seq_JURKAT_Human1.01717355
128MYB_26560356_Chip-Seq_TH2_Human1.01513528
129CLOCK_20551151_ChIP-Seq_293T_Human1.01507617
130LXR_22158963_ChIP-Seq_LIVER_Mouse1.01444944
131ATF3_27146783_Chip-Seq_COLON_Human1.01108480
132NCOR1_26117541_ChIP-Seq_K562_Human1.00464535
133TRIM28_21343339_ChIP-Seq_HEK293_Human1.00212352
134TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99532364
135EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99238558
136PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99146034

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow3.85726396
2* MP0005058_abnormal_lysosome_morphology3.69886224
3MP0005171_absent_coat_pigmentation2.89106512
4MP0003172_abnormal_lysosome_physiology2.74866024
5MP0008057_abnormal_DNA_replication2.72822553
6MP0000685_abnormal_immune_system2.39215047
7MP0005174_abnormal_tail_pigmentation2.31950771
8MP0005397_hematopoietic_system_phenotyp2.28091191
9MP0001545_abnormal_hematopoietic_system2.28091191
10MP0008438_abnormal_cutaneous_collagen2.21877662
11MP0002009_preneoplasia2.18137863
12MP0006082_CNS_inflammation2.10359430
13MP0002405_respiratory_system_inflammati1.96198919
14MP0000015_abnormal_ear_pigmentation1.95265917
15MP0001835_abnormal_antigen_presentation1.92001373
16MP0005464_abnormal_platelet_physiology1.89566521
17MP0003566_abnormal_cell_adhesion1.88283199
18MP0005451_abnormal_body_composition1.80920520
19MP0003453_abnormal_keratinocyte_physiol1.80200483
20MP0002166_altered_tumor_susceptibility1.74332382
21MP0003828_pulmonary_edema1.74101147
22MP0008260_abnormal_autophagy1.67362259
23MP0008995_early_reproductive_senescence1.66847301
24MP0010030_abnormal_orbit_morphology1.62209861
25MP0009840_abnormal_foam_cell1.55463991
26MP0002419_abnormal_innate_immunity1.53559287
27MP0001790_abnormal_immune_system1.52242339
28MP0005387_immune_system_phenotype1.52242339
29MP0003191_abnormal_cellular_cholesterol1.51889133
30MP0009333_abnormal_splenocyte_physiolog1.50974163
31MP0001800_abnormal_humoral_immune1.50484575
32MP0000371_diluted_coat_color1.50328100
33MP0009384_cardiac_valve_regurgitation1.50191220
34MP0002254_reproductive_system_inflammat1.49320175
35MP0004233_abnormal_muscle_weight1.48674516
36MP0002452_abnormal_antigen_presenting1.47802761
37MP0006054_spinal_hemorrhage1.46696197
38MP0003436_decreased_susceptibility_to1.46028402
39MP0000490_abnormal_crypts_of1.44974914
40MP0010352_gastrointestinal_tract_polyps1.44814667
41MP0003705_abnormal_hypodermis_morpholog1.44796977
42MP0003763_abnormal_thymus_physiology1.43790013
43MP0000604_amyloidosis1.40893899
44MP0010155_abnormal_intestine_physiology1.38683769
45MP0001542_abnormal_bone_strength1.38364866
46* MP0000689_abnormal_spleen_morphology1.37121465
47MP0001873_stomach_inflammation1.36501874
48MP0002006_tumorigenesis1.34670569
49MP0002148_abnormal_hypersensitivity_rea1.34319155
50MP0003045_fibrosis1.34131385
51MP0002060_abnormal_skin_morphology1.32620633
52MP0003279_aneurysm1.32094963
53MP0005076_abnormal_cell_differentiation1.30587332
54MP0005025_abnormal_response_to1.29199737
55MP0002723_abnormal_immune_serum1.28629280
56MP0005000_abnormal_immune_tolerance1.28550167
57MP0000767_abnormal_smooth_muscle1.28281664
58MP0002396_abnormal_hematopoietic_system1.26810675
59MP0002420_abnormal_adaptive_immunity1.25270111
60MP0004858_abnormal_nervous_system1.23873588
61MP0001819_abnormal_immune_cell1.23443371
62MP0003300_gastrointestinal_ulcer1.21956583
63MP0005671_abnormal_response_to1.21771460
64MP0002398_abnormal_bone_marrow1.21765788
65MP0001853_heart_inflammation1.18468953
66MP0001849_ear_inflammation1.18330898
67MP0005670_abnormal_white_adipose1.17758549
68MP0005075_abnormal_melanosome_morpholog1.16954882
69MP0005023_abnormal_wound_healing1.14300814
70MP0000716_abnormal_immune_system1.13071897
71MP0001348_abnormal_lacrimal_gland1.10674142
72MP0005310_abnormal_salivary_gland1.10033864
73MP0009764_decreased_sensitivity_to1.08273927
74MP0001845_abnormal_inflammatory_respons1.08201594
75* MP0002722_abnormal_immune_system1.07582351
76MP0002933_joint_inflammation1.07535564
77MP0003448_altered_tumor_morphology1.07014636
78MP0000343_altered_response_to1.03493768
79MP0004381_abnormal_hair_follicle1.03371506
80MP0003075_altered_response_to1.02125621
81MP0003724_increased_susceptibility_to1.00697798
82MP0003656_abnormal_erythrocyte_physiolo1.00370725
83MP0002429_abnormal_blood_cell1.00026419
84MP0000465_gastrointestinal_hemorrhage0.96909806
85MP0005365_abnormal_bile_salt0.96543852
86MP0003795_abnormal_bone_structure0.96019913
87MP0009115_abnormal_fat_cell0.95751776
88MP0004947_skin_inflammation0.95137279
89MP0004510_myositis0.92436907
90MP0005164_abnormal_response_to0.92218261
91MP0005503_abnormal_tendon_morphology0.91796537
92MP0003283_abnormal_digestive_organ0.91194054
93MP0009785_altered_susceptibility_to0.91025060
94MP0003329_amyloid_beta_deposits0.90817414
95MP0002877_abnormal_melanocyte_morpholog0.90396208
96MP0002998_abnormal_bone_remodeling0.89361847
97MP0003943_abnormal_hepatobiliary_system0.87382172
98MP0001851_eye_inflammation0.87377308
99MP0003303_peritoneal_inflammation0.84960536
100MP0002282_abnormal_trachea_morphology0.84498601
101MP0004883_abnormal_blood_vessel0.84231315
102MP0010307_abnormal_tumor_latency0.84096791
103MP0001533_abnormal_skeleton_physiology0.83551747
104MP0005409_darkened_coat_color0.82466206
105MP0000639_abnormal_adrenal_gland0.81818068
106MP0002019_abnormal_tumor_incidence0.81260212
107MP0002249_abnormal_larynx_morphology0.80408967
108MP0005257_abnormal_intraocular_pressure0.79687162
109MP0002086_abnormal_extraembryonic_tissu0.79380652
110MP0000249_abnormal_blood_vessel0.78185803
111MP0000703_abnormal_thymus_morphology0.77616122
112MP0000579_abnormal_nail_morphology0.77313723
113MP0003183_abnormal_peptide_metabolism0.77185215
114MP0005390_skeleton_phenotype0.76545989
115MP0000470_abnormal_stomach_morphology0.76539837
116MP0003690_abnormal_glial_cell0.76296065
117MP0004808_abnormal_hematopoietic_stem0.75213115
118MP0001958_emphysema0.74204391
119MP0003786_premature_aging0.73718988
120MP0002075_abnormal_coat/hair_pigmentati0.72003503
121MP0001243_abnormal_dermal_layer0.71904589
122MP0005166_decreased_susceptibility_to0.71225990
123MP0005508_abnormal_skeleton_morphology0.70860325
124MP0000858_altered_metastatic_potential0.70537681
125MP0003866_abnormal_defecation0.70424070
126MP0004272_abnormal_basement_membrane0.69985309
127MP0003091_abnormal_cell_migration0.69976903
128MP0002896_abnormal_bone_mineralization0.69625771
129MP0000751_myopathy0.69333868
130MP0008469_abnormal_protein_level0.67884950
131MP0000609_abnormal_liver_physiology0.66946068
132MP0001663_abnormal_digestive_system0.63872339

Predicted human phenotypes

RankGene SetZ-score
1Pustule (HP:0200039)5.84310726
2Abnormality of glycolipid metabolism (HP:0010969)4.89411153
3Abnormality of liposaccharide metabolism (HP:0010968)4.89411153
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.89411153
5* Dysostosis multiplex (HP:0000943)4.69151905
6Cerebral aneurysm (HP:0004944)4.31755782
7Alopecia of scalp (HP:0002293)4.26099852
8Ulnar bowing (HP:0003031)3.94787007
9Increased IgM level (HP:0003496)3.86344518
10Cervical subluxation (HP:0003308)3.75063325
11* Urinary glycosaminoglycan excretion (HP:0003541)3.72682395
12* Mucopolysacchariduria (HP:0008155)3.72682395
13Poikiloderma (HP:0001029)3.71465810
14Turricephaly (HP:0000262)3.52143824
15Systemic lupus erythematosus (HP:0002725)3.47343501
16Rib fusion (HP:0000902)3.41540366
17Recurrent abscess formation (HP:0002722)3.39011255
18* Abnormality of mucopolysaccharide metabolism (HP:0011020)3.36214420
19* Abnormality of polysaccharide metabolism (HP:0011012)3.36214420
20* Abnormality of glycosaminoglycan metabolism (HP:0004371)3.36214420
21Loss of speech (HP:0002371)3.35123137
22Intestinal fistula (HP:0100819)3.34221238
23Rectovaginal fistula (HP:0000143)3.29586357
24Rectal fistula (HP:0100590)3.29586357
25Thin bony cortex (HP:0002753)3.28606075
26Vacuolated lymphocytes (HP:0001922)3.27779160
27Vaginal fistula (HP:0004320)3.13029546
28Annular pancreas (HP:0001734)3.07657370
29Abnormality of male internal genitalia (HP:0000022)3.02807743
30Tongue fasciculations (HP:0001308)2.96898596
31Concave nail (HP:0001598)2.93631166
32Abnormal hemoglobin (HP:0011902)2.93627373
33Albinism (HP:0001022)2.89413808
34IgA deficiency (HP:0002720)2.86782124
35Muscle fibrillation (HP:0010546)2.86540730
36Myocardial infarction (HP:0001658)2.84881199
37Colitis (HP:0002583)2.83591983
38Clumsiness (HP:0002312)2.82163705
39Increased cerebral lipofuscin (HP:0011813)2.78735997
40Male infertility (HP:0003251)2.75039864
41Recurrent bacterial skin infections (HP:0005406)2.73912646
42Premature skin wrinkling (HP:0100678)2.72475447
43Facial hemangioma (HP:0000329)2.71725108
44Large for gestational age (HP:0001520)2.69152860
45Coronal craniosynostosis (HP:0004440)2.67327802
46* Joint stiffness (HP:0001387)2.66513053
47Vertebral hypoplasia (HP:0008417)2.66112656
48Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.66112656
49Eczematoid dermatitis (HP:0000976)2.65318806
50Broad face (HP:0000283)2.59604359
51Inflammation of the large intestine (HP:0002037)2.56391108
52Orchitis (HP:0100796)2.53414791
53Recurrent fungal infections (HP:0002841)2.51946399
54Polycythemia (HP:0001901)2.50591165
55Increased neuronal autofluorescent lipopigment (HP:0002074)2.46850151
56Nephritis (HP:0000123)2.46372917
57Nuclear cataract (HP:0100018)2.42751474
58J-shaped sella turcica (HP:0002680)2.40389990
59Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.38057393
60Hemorrhage of the eye (HP:0011885)2.37946248
61Gastrointestinal inflammation (HP:0004386)2.37095698
62Petechiae (HP:0000967)2.32159770
63Cheilitis (HP:0100825)2.28867333
64Bowing of the arm (HP:0006488)2.28194758
65Bowed forearm bones (HP:0003956)2.28194758
66Vertebral compression fractures (HP:0002953)2.26002085
67Aortic aneurysm (HP:0004942)2.25989048
68Glomerulonephritis (HP:0000099)2.24738616
69Hematochezia (HP:0002573)2.21951880
70Abnormal platelet volume (HP:0011876)2.20935502
71Congenital hip dislocation (HP:0001374)2.20639454
72Biconcave vertebral bodies (HP:0004586)2.19466951
73Spontaneous hematomas (HP:0007420)2.17231614
74Prolonged bleeding time (HP:0003010)2.16644103
75Hypokinesia (HP:0002375)2.15619309
76Short humerus (HP:0005792)2.14289246
77Optic neuritis (HP:0100653)2.13126240
78Retrobulbar optic neuritis (HP:0100654)2.13126240
79Bilateral sensorineural hearing impairment (HP:0008619)2.12265353
80Dilatation of the ascending aorta (HP:0005111)2.11198079
81Mesangial abnormality (HP:0001966)2.11180941
82Interstitial pulmonary disease (HP:0006530)2.10465190
83Abnormality of macrophages (HP:0004311)2.10218425
84Emphysema (HP:0002097)2.08227965
85Progressive neurologic deterioration (HP:0002344)2.07951029
86Anteriorly placed anus (HP:0001545)2.07247419
87Flared iliac wings (HP:0002869)2.06505312
88Aneurysm (HP:0002617)2.06462249
89Diaphragmatic weakness (HP:0009113)2.05841968
90Pulmonary infiltrates (HP:0002113)2.05010315
91Obstructive sleep apnea (HP:0002870)2.05008277
92Increased mean platelet volume (HP:0011877)2.03719048
93Axonal loss (HP:0003447)2.03325548
94Growth hormone excess (HP:0000845)2.02313018
95Spondylolisthesis (HP:0003302)2.02108835
96Hypochromic microcytic anemia (HP:0004840)2.01551465
97Persistence of primary teeth (HP:0006335)2.01533290
98Premature rupture of membranes (HP:0001788)2.00238016
99Peritonitis (HP:0002586)2.00051586
100Purpura (HP:0000979)1.99942651
101Generalized amyotrophy (HP:0003700)1.99832396
102Gastrointestinal infarctions (HP:0005244)1.99232237
103Hypochromic anemia (HP:0001931)1.98406752
104Increased CSF protein (HP:0002922)1.97567791
105Abnormality of complement system (HP:0005339)1.97469560
106Protrusio acetabuli (HP:0003179)1.97415556
107Premature loss of primary teeth (HP:0006323)1.95337515
108Recurrent skin infections (HP:0001581)1.92961082
109Gingivitis (HP:0000230)1.90306423
110Amyloidosis (HP:0011034)1.90105400
111Aortic regurgitation (HP:0001659)1.90067279
112Stomatitis (HP:0010280)1.89618896
113Neuronal loss in central nervous system (HP:0002529)1.89402835
114Aplasia/hypoplasia of the humerus (HP:0006507)1.89238608
115Vascular tortuosity (HP:0004948)1.89044160
116Bone pain (HP:0002653)1.89038708
117Neurofibrillary tangles (HP:0002185)1.88858260
118Hypergammaglobulinemia (HP:0010702)1.88750745
119Increased serum ferritin (HP:0003281)1.88271959
120Orthostatic hypotension (HP:0001278)1.84651664
121Recurrent gram-negative bacterial infections (HP:0005420)1.83973506
122Aortic dissection (HP:0002647)1.83112725
123Long toe (HP:0010511)1.81981524
124Menorrhagia (HP:0000132)1.81185685
125Chronic mucocutaneous candidiasis (HP:0002728)1.79539794
126Recurrent cutaneous fungal infections (HP:0011370)1.79539794
127Genu recurvatum (HP:0002816)1.79486592
128Restrictive lung disease (HP:0002091)1.79366220
129* Coarse hair (HP:0002208)1.79151457
130Abnormality of the vasculature of the conjunctiva (HP:0008054)1.78622492
131Mediastinal lymphadenopathy (HP:0100721)1.78509463
132Ulnar deviation of the wrist (HP:0003049)1.77788569
133Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.77396953
134Hepatosplenomegaly (HP:0001433)1.76735696
135Elevated erythrocyte sedimentation rate (HP:0003565)1.76629816
136Recurrent viral infections (HP:0004429)1.76239687
137Squamous cell carcinoma (HP:0002860)1.76180565
138Intestinal atresia (HP:0011100)1.75819089
139Bifid uvula (HP:0000193)1.75332851
140Hemoptysis (HP:0002105)1.75169410
141Nasal polyposis (HP:0100582)1.74170693
142Wormian bones (HP:0002645)1.73709358
143Blue sclerae (HP:0000592)1.73123179
144Abnormality of the nasal mucosa (HP:0000433)1.72460390
145Myositis (HP:0100614)1.71598924
146Abnormality of T cell physiology (HP:0011840)1.70561897
147Femoral bowing (HP:0002980)1.70225426
148Prolonged neonatal jaundice (HP:0006579)1.69370736
149Syringomyelia (HP:0003396)1.69235729
150Spinal cord lesions (HP:0100561)1.69235729
151Pancreatic islet-cell hyperplasia (HP:0004510)1.68995219
152Arterial tortuosity (HP:0005116)1.68969290
153* Ovoid vertebral bodies (HP:0003300)1.68910115
154Epistaxis (HP:0000421)1.68822280
155Spinal muscular atrophy (HP:0007269)1.68723063
156Ankle contracture (HP:0006466)1.68586186
157Acrocyanosis (HP:0001063)1.67736085
158Mitral regurgitation (HP:0001653)1.67689865
159Achilles tendon contracture (HP:0001771)1.67074780
160Distal upper limb amyotrophy (HP:0007149)1.66847293
161Upper limb amyotrophy (HP:0009129)1.66847293
162Disproportionate tall stature (HP:0001519)1.64993161
163Chronic obstructive pulmonary disease (HP:0006510)1.63602026
164Obstructive lung disease (HP:0006536)1.63602026
165Stridor (HP:0010307)1.62403824
166Abnormality of the thoracic spine (HP:0100711)1.62193224

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.46599021
2DDR24.10840848
3MAPK154.08679299
4MAP3K63.50764940
5FGR3.06098973
6BMX2.95372320
7MAP3K112.79565569
8MATK2.49003400
9CSK2.40973995
10MAP4K12.32301810
11PRKD22.19980362
12TRPM72.17736066
13TRIB32.14578812
14PDGFRA1.93036361
15PIM21.92176120
16PINK11.87912373
17RIPK41.87860498
18TGFBR21.81670911
19MAP3K31.81260323
20TYRO31.78248677
21DYRK1B1.76602193
22YES11.68173378
23MAP3K131.63014039
24TESK21.57576951
25DAPK11.48728904
26CDK61.48300645
27PIM11.45070869
28ERN11.44995717
29SMG11.40680082
30BLK1.39845060
31CSF1R1.35244878
32STK101.33263893
33SIK31.25048657
34UHMK11.23807338
35TYK21.22003756
36TAOK21.19650455
37RPS6KL11.16986422
38RPS6KC11.16986422
39GRK71.14089527
40IRAK31.11920803
41KIT1.11497243
42RPS6KA61.11358581
43MAPK111.10368044
44TBK11.09748740
45TAOK11.09263747
46MARK21.08565662
47TAOK31.08531992
48CDK71.03593169
49GSK3A1.01723729
50FES1.01462128
51MAP3K101.00698617
52RPS6KA20.99941373
53NME20.98360944
54ZAP700.96605624
55SIK20.96406420
56IKBKB0.94697114
57TESK10.93865014
58MAPK70.93756996
59PDPK10.91274994
60LYN0.89789057
61MAP2K20.89723384
62NEK90.87985118
63CDC42BPA0.86216193
64PDGFRB0.84967987
65TTN0.82259423
66TXK0.81042605
67LCK0.78746590
68HIPK20.78218606
69MAP3K70.77796511
70MET0.77268673
71MAP3K10.77029145
72PKN20.74656744
73JAK30.74499877
74EGFR0.74437241
75MOS0.73475178
76EEF2K0.70820113
77SIK10.69839238
78JAK10.69238286
79STK380.68730091
80MTOR0.67071542
81CDK120.66670766
82MAPK120.65757291
83MARK30.65220654
84CAMKK10.64669981
85JAK20.64606418
86DMPK0.63913807
87MAP2K30.63901340
88MAP2K60.62415156
89PDK10.62079276
90PTK20.61660711
91BTK0.60919033
92CAMK1D0.60894887
93CHUK0.60402714
94MAP3K140.59189290
95PRPF4B0.58779602
96ITK0.55388934
97IRAK40.53712872
98CAMKK20.52847355
99EPHA20.51850265
100LRRK20.51682012
101AKT30.51347332
102IRAK20.51135584
103GRK60.51026229
104RIPK10.50426468
105MAPK30.49741548
106HCK0.47480560
107TNK20.46819960
108PTK2B0.46392692
109RPS6KA10.46051266
110TEC0.46018586
111PRKAA20.45580553
112FGFR30.45219231
113FLT30.44579027
114EPHB10.44310275
115PTK60.44258816
116INSR0.43309702
117MAPKAPK20.42724539
118CHEK20.41344265
119STK30.41114570
120CDK40.40623865
121CLK10.40234651
122PRKD10.39430965
123PHKG20.38683628
124PHKG10.38683628
125SYK0.38622927
126PRKCD0.38492128
127PAK40.36826942
128MAPK10.36393811
129PRKAA10.34484107
130PRKCH0.31203626
131PAK20.31003995
132FGFR40.30959222
133IKBKE0.28934506

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.72195548
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.96839399
3Base excision repair_Homo sapiens_hsa034102.94933410
4Other glycan degradation_Homo sapiens_hsa005112.58984016
5Primary immunodeficiency_Homo sapiens_hsa053402.39731279
6Staphylococcus aureus infection_Homo sapiens_hsa051502.30003404
7* Glycosaminoglycan degradation_Homo sapiens_hsa005312.19292595
8* Lysosome_Homo sapiens_hsa041422.18675164
9Notch signaling pathway_Homo sapiens_hsa043301.99360463
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.83730169
11Mismatch repair_Homo sapiens_hsa034301.72271395
12Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.71502280
13Legionellosis_Homo sapiens_hsa051341.65373903
14Leishmaniasis_Homo sapiens_hsa051401.63948901
15Lysine degradation_Homo sapiens_hsa003101.60058593
16Shigellosis_Homo sapiens_hsa051311.58637770
17Adherens junction_Homo sapiens_hsa045201.54500464
18B cell receptor signaling pathway_Homo sapiens_hsa046621.52884501
19Allograft rejection_Homo sapiens_hsa053301.50265545
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.43430983
21Measles_Homo sapiens_hsa051621.34429074
22Autoimmune thyroid disease_Homo sapiens_hsa053201.33103525
23mTOR signaling pathway_Homo sapiens_hsa041501.32405983
24Osteoclast differentiation_Homo sapiens_hsa043801.31854922
25Rheumatoid arthritis_Homo sapiens_hsa053231.31363742
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29908415
27Malaria_Homo sapiens_hsa051441.29776998
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.28548274
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.27887960
30T cell receptor signaling pathway_Homo sapiens_hsa046601.21763294
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.19217061
32Chronic myeloid leukemia_Homo sapiens_hsa052201.16564401
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13596123
34Small cell lung cancer_Homo sapiens_hsa052221.12069779
35Hepatitis C_Homo sapiens_hsa051601.11492764
36Hematopoietic cell lineage_Homo sapiens_hsa046401.10465296
37Antigen processing and presentation_Homo sapiens_hsa046121.10113823
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08168720
39Tuberculosis_Homo sapiens_hsa051521.06672592
40DNA replication_Homo sapiens_hsa030301.06437613
41Viral myocarditis_Homo sapiens_hsa054161.06238822
42Pertussis_Homo sapiens_hsa051331.04404621
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03423227
44Longevity regulating pathway - mammal_Homo sapiens_hsa042111.03281403
45Acute myeloid leukemia_Homo sapiens_hsa052211.02844259
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00987193
47Salmonella infection_Homo sapiens_hsa051320.99103771
48p53 signaling pathway_Homo sapiens_hsa041150.98610338
49Bladder cancer_Homo sapiens_hsa052190.98156637
50Fatty acid metabolism_Homo sapiens_hsa012120.97567387
51Regulation of actin cytoskeleton_Homo sapiens_hsa048100.96772161
52Intestinal immune network for IgA production_Homo sapiens_hsa046720.94775632
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93644544
54Asthma_Homo sapiens_hsa053100.93370706
55Arginine and proline metabolism_Homo sapiens_hsa003300.92939346
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92745044
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.91849443
58Fructose and mannose metabolism_Homo sapiens_hsa000510.91757251
59Non-small cell lung cancer_Homo sapiens_hsa052230.91301776
60Herpes simplex infection_Homo sapiens_hsa051680.91275925
61Renin-angiotensin system_Homo sapiens_hsa046140.91101896
62Selenocompound metabolism_Homo sapiens_hsa004500.90195840
63Apoptosis_Homo sapiens_hsa042100.89227574
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88469072
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87721943
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.87677487
67TGF-beta signaling pathway_Homo sapiens_hsa043500.87569276
68Galactose metabolism_Homo sapiens_hsa000520.87533075
69Hepatitis B_Homo sapiens_hsa051610.87495822
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.86384731
71Prolactin signaling pathway_Homo sapiens_hsa049170.85994982
72Sphingolipid metabolism_Homo sapiens_hsa006000.85361564
73VEGF signaling pathway_Homo sapiens_hsa043700.84797082
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84755583
75Focal adhesion_Homo sapiens_hsa045100.81437048
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.79622911
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.79565058
78Type I diabetes mellitus_Homo sapiens_hsa049400.77853043
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77434665
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76865506
81Sulfur relay system_Homo sapiens_hsa041220.76191880
82Amoebiasis_Homo sapiens_hsa051460.75801062
83Hippo signaling pathway_Homo sapiens_hsa043900.75638326
84Toxoplasmosis_Homo sapiens_hsa051450.75240414
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73839082
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.73190279
87Pancreatic cancer_Homo sapiens_hsa052120.72226678
88Prion diseases_Homo sapiens_hsa050200.72006221
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71884526
90Insulin resistance_Homo sapiens_hsa049310.71539434
91Circadian rhythm_Homo sapiens_hsa047100.70903461
92Proteoglycans in cancer_Homo sapiens_hsa052050.70173357
93Chemokine signaling pathway_Homo sapiens_hsa040620.69967342
94Phagosome_Homo sapiens_hsa041450.69375929
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68283436
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63056265
97GnRH signaling pathway_Homo sapiens_hsa049120.61904637
98Complement and coagulation cascades_Homo sapiens_hsa046100.61693169
99Renal cell carcinoma_Homo sapiens_hsa052110.61464600
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61292807
101Endocytosis_Homo sapiens_hsa041440.58921775
102Platelet activation_Homo sapiens_hsa046110.58358596
103Vibrio cholerae infection_Homo sapiens_hsa051100.56913431
104One carbon pool by folate_Homo sapiens_hsa006700.56549764
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56285904
106Folate biosynthesis_Homo sapiens_hsa007900.55297895
107Endometrial cancer_Homo sapiens_hsa052130.55139598
108TNF signaling pathway_Homo sapiens_hsa046680.55006039
109Choline metabolism in cancer_Homo sapiens_hsa052310.54783511
110Arachidonic acid metabolism_Homo sapiens_hsa005900.54255267
111Graft-versus-host disease_Homo sapiens_hsa053320.53755973
112African trypanosomiasis_Homo sapiens_hsa051430.52825470
113Prostate cancer_Homo sapiens_hsa052150.50348279
114Hedgehog signaling pathway_Homo sapiens_hsa043400.50259883
115MicroRNAs in cancer_Homo sapiens_hsa052060.49899261
116FoxO signaling pathway_Homo sapiens_hsa040680.48699763
117Insulin signaling pathway_Homo sapiens_hsa049100.48082632
118ABC transporters_Homo sapiens_hsa020100.47766057
119Influenza A_Homo sapiens_hsa051640.47379948
120Biosynthesis of amino acids_Homo sapiens_hsa012300.47334192
121Starch and sucrose metabolism_Homo sapiens_hsa005000.47262287
122Colorectal cancer_Homo sapiens_hsa052100.46320539
123HIF-1 signaling pathway_Homo sapiens_hsa040660.45555215
124MAPK signaling pathway_Homo sapiens_hsa040100.45399013
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45374771
126Epstein-Barr virus infection_Homo sapiens_hsa051690.45060525
127Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43205390
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.42730797
129Caffeine metabolism_Homo sapiens_hsa002320.42639322
130Viral carcinogenesis_Homo sapiens_hsa052030.40991513
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40192774
132HTLV-I infection_Homo sapiens_hsa051660.39971160

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