SGSM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.28914075
2synaptic vesicle docking involved in exocytosis (GO:0016081)5.25414806
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.83949050
4synaptic vesicle exocytosis (GO:0016079)4.83507120
5vocalization behavior (GO:0071625)4.82387366
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.73481238
7negative regulation of cell killing (GO:0031342)4.73481238
8regulation of synaptic vesicle exocytosis (GO:2000300)4.65919888
9glutamate secretion (GO:0014047)4.59317541
10negative regulation of erythrocyte differentiation (GO:0045647)4.58941274
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.44707468
12antigen processing and presentation of endogenous antigen (GO:0019883)4.37022037
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.34965353
14positive regulation of synapse maturation (GO:0090129)4.32776090
15mannose metabolic process (GO:0006013)4.24703896
16regulation of synaptic vesicle transport (GO:1902803)4.24214388
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.22182086
18neuron cell-cell adhesion (GO:0007158)4.11207027
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.10166441
20locomotory exploration behavior (GO:0035641)4.07047486
21synaptic vesicle maturation (GO:0016188)3.93287022
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.91113773
23regulation of glutamate receptor signaling pathway (GO:1900449)3.87457645
24protein localization to synapse (GO:0035418)3.87358235
25neurotransmitter secretion (GO:0007269)3.85588749
26positive thymic T cell selection (GO:0045059)3.81594789
27positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.77672315
28positive regulation of gamma-delta T cell activation (GO:0046645)3.75216529
29piRNA metabolic process (GO:0034587)3.67946001
30thymic T cell selection (GO:0045061)3.58660544
31exploration behavior (GO:0035640)3.56122699
32regulation of ARF protein signal transduction (GO:0032012)3.52624526
33neurotransmitter-gated ion channel clustering (GO:0072578)3.50314168
34neuronal action potential propagation (GO:0019227)3.48516614
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.43408105
36regulation of synapse maturation (GO:0090128)3.41542820
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.39606004
38synaptic transmission, glutamatergic (GO:0035249)3.39427788
39regulation of gamma-delta T cell differentiation (GO:0045586)3.37031677
40response to muramyl dipeptide (GO:0032495)3.36814898
41regulation of neuronal synaptic plasticity (GO:0048168)3.35146937
42innervation (GO:0060384)3.30995874
43COPI coating of Golgi vesicle (GO:0048205)3.29496478
44Golgi transport vesicle coating (GO:0048200)3.29496478
45neuron-neuron synaptic transmission (GO:0007270)3.28154228
46negative regulation of cell size (GO:0045792)3.26103722
47regulation of long-term neuronal synaptic plasticity (GO:0048169)3.25831578
48NIK/NF-kappaB signaling (GO:0038061)3.24365659
49B cell receptor signaling pathway (GO:0050853)3.22898207
50ATP hydrolysis coupled proton transport (GO:0015991)3.22464493
51energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.22464493
52long-term synaptic potentiation (GO:0060291)3.22164182
53regulation of gamma-delta T cell activation (GO:0046643)3.22126206
54transferrin transport (GO:0033572)3.20120037
55regulation of synapse structural plasticity (GO:0051823)3.17359929
56postsynaptic membrane organization (GO:0001941)3.16697469
57synaptic vesicle endocytosis (GO:0048488)3.15289383
58ionotropic glutamate receptor signaling pathway (GO:0035235)3.15112255
59positive regulation of membrane potential (GO:0045838)3.14624584
60detection of bacterium (GO:0016045)3.09615532
61calcium ion-dependent exocytosis (GO:0017156)3.08917400
62regulation of neurotransmitter secretion (GO:0046928)3.06901381
63glutamate receptor signaling pathway (GO:0007215)3.06752840
64positive regulation of neurotransmitter transport (GO:0051590)3.06203180
65retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.05125957
66positive regulation of Cdc42 GTPase activity (GO:0043089)3.04312752
67germinal center formation (GO:0002467)3.00720995
68regulation of synaptic plasticity (GO:0048167)3.00651691
69negative thymic T cell selection (GO:0045060)2.99795519
70positive regulation of neurotransmitter secretion (GO:0001956)2.98473112
71neurotransmitter transport (GO:0006836)2.97543043
72male meiosis (GO:0007140)2.97253410
73regulation of ARF GTPase activity (GO:0032312)2.95004591
74barbed-end actin filament capping (GO:0051016)2.94246107
75ferric iron transport (GO:0015682)2.93778270
76trivalent inorganic cation transport (GO:0072512)2.93778270
77regulation of excitatory postsynaptic membrane potential (GO:0060079)2.92933624
78regulation of cilium movement (GO:0003352)2.92207137
79presynaptic membrane assembly (GO:0097105)2.92139364
80gamma-aminobutyric acid signaling pathway (GO:0007214)2.91256719
81T cell selection (GO:0045058)2.90568058
82regulation of synaptic transmission, glutamatergic (GO:0051966)2.90003790
83regulation of vesicle fusion (GO:0031338)2.88753542
84peptidyl-tyrosine autophosphorylation (GO:0038083)2.88368480
85detection of other organism (GO:0098543)2.87431219
86regulation of calcium ion-dependent exocytosis (GO:0017158)2.83973816
87regulation of postsynaptic membrane potential (GO:0060078)2.83045309
88positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.82403465
89regulation of neurotransmitter transport (GO:0051588)2.82038660
90proline transport (GO:0015824)2.80888860
91membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.79043751
92regulation of neurotransmitter levels (GO:0001505)2.78931905
93vesicle transport along microtubule (GO:0047496)2.78250079
94protein localization to cilium (GO:0061512)2.78169653
95positive regulation of synaptic transmission, GABAergic (GO:0032230)2.77500898
96layer formation in cerebral cortex (GO:0021819)2.76977694
97activation of JUN kinase activity (GO:0007257)2.76929721
98activation of MAPKKK activity (GO:0000185)2.76504529
99negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.76027128
100regulation of T-helper 2 cell differentiation (GO:0045628)2.75939738
101negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.75316330
102negative regulation of leukocyte mediated immunity (GO:0002704)2.74994911
103behavioral response to ethanol (GO:0048149)2.74979939
104immunoglobulin mediated immune response (GO:0016064)2.74577780
105negative regulation of dendrite morphogenesis (GO:0050774)2.72629009
106negative regulation of myotube differentiation (GO:0010832)2.72100732
107negative regulation of lymphocyte mediated immunity (GO:0002707)2.71782281
108regulation of type I interferon-mediated signaling pathway (GO:0060338)2.71576890
109histone H4 deacetylation (GO:0070933)2.71390231
110intracellular estrogen receptor signaling pathway (GO:0030520)2.70723443
111activation of protein kinase A activity (GO:0034199)2.70722782
112detection of calcium ion (GO:0005513)2.70173723
113establishment of synaptic vesicle localization (GO:0097480)2.69885806
114synaptic vesicle transport (GO:0048489)2.69885806
115negative regulation of synaptic transmission, GABAergic (GO:0032229)2.69078313
116modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.68991817
117positive regulation by organism of defense response of other organism involved in symbiotic interact2.68991817
118modulation by symbiont of host immune response (GO:0052553)2.68991817
119positive regulation by symbiont of host defense response (GO:0052509)2.68991817
120modulation by symbiont of host defense response (GO:0052031)2.68991817
121modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.68991817
122cerebellar Purkinje cell differentiation (GO:0021702)2.68690898
123regulation of defense response to virus by virus (GO:0050690)2.68509483
124signal complex assembly (GO:0007172)2.68215735
125negative T cell selection (GO:0043383)2.68146454
126DNA methylation involved in gamete generation (GO:0043046)2.66961576
127membrane hyperpolarization (GO:0060081)2.66938308
128regulation of dendritic cell antigen processing and presentation (GO:0002604)2.66305802
129startle response (GO:0001964)2.65847761
130long term synaptic depression (GO:0060292)2.65773078
131positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.65285448
132positive regulation of synaptic transmission (GO:0050806)2.65231907
133negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.61771632
134regulation of leukocyte degranulation (GO:0043300)2.60782104
135G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.60541566
136neuromuscular process controlling posture (GO:0050884)2.60198771
137establishment of vesicle localization (GO:0051650)2.59866798
138response to histamine (GO:0034776)2.59839068
139membrane depolarization during action potential (GO:0086010)2.59337390
140cellular response to virus (GO:0098586)2.58923838
141GDP-mannose metabolic process (GO:0019673)2.58249680
142Arp2/3 complex-mediated actin nucleation (GO:0034314)2.57987195
143tolerance induction (GO:0002507)2.57970879
144neuromuscular process controlling balance (GO:0050885)2.57905097
145G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.57563582
146protein localization to endosome (GO:0036010)2.57472989
147negative regulation of microtubule polymerization (GO:0031115)2.57221463
148inositol phosphate catabolic process (GO:0071545)2.57211842
149striatum development (GO:0021756)2.57100028
150semaphorin-plexin signaling pathway (GO:0071526)2.56978773
1513-UTR-mediated mRNA stabilization (GO:0070935)2.56976710
152positive T cell selection (GO:0043368)2.56607406
153response to auditory stimulus (GO:0010996)2.55804505
154long-term memory (GO:0007616)2.55638481
155modulation by virus of host process (GO:0019054)2.55420491
156positive regulation of Rap GTPase activity (GO:0032854)2.55169098
157positive regulation of exocytosis (GO:0045921)2.53740095
158serotonin metabolic process (GO:0042428)2.53667487
159negative regulation of innate immune response (GO:0045824)2.53565949
160negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.53552982
161protein retention in ER lumen (GO:0006621)2.53478258
162synaptonemal complex organization (GO:0070193)2.52380907
163auditory behavior (GO:0031223)2.51900262
164phosphorelay signal transduction system (GO:0000160)2.51229119
165presynaptic membrane organization (GO:0097090)2.51123030
166epithelial cell differentiation involved in prostate gland development (GO:0060742)2.50353745
167leukocyte aggregation (GO:0070486)2.49751390
168negative regulation of toll-like receptor signaling pathway (GO:0034122)2.46491150
169retrograde transport, endosome to Golgi (GO:0042147)2.45787411
170histone H3 deacetylation (GO:0070932)2.45547262
171modulation by symbiont of host cellular process (GO:0044068)2.45466841
172regulation of interferon-beta biosynthetic process (GO:0045357)2.44863441
173negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.44749712
174regulation of myeloid leukocyte mediated immunity (GO:0002886)2.42493976
175cytoskeletal anchoring at plasma membrane (GO:0007016)2.40947251
176positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.39786354
177macrophage activation involved in immune response (GO:0002281)2.39761590
178mucosal-associated lymphoid tissue development (GO:0048537)2.38768854
179Peyers patch development (GO:0048541)2.38768854
180regulation of glucose import in response to insulin stimulus (GO:2001273)2.38594439
181histone H3-K36 demethylation (GO:0070544)2.38231049
182regulation of extracellular matrix disassembly (GO:0010715)2.37781221
183response to laminar fluid shear stress (GO:0034616)2.36548079
184actin filament polymerization (GO:0030041)2.36409756
185regulation of necrotic cell death (GO:0010939)2.34490319
186regulation of necroptotic process (GO:0060544)2.33942069
187UV protection (GO:0009650)2.31771928
188regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.31022058
189positive regulation of protein dephosphorylation (GO:0035307)2.30960607
190phosphatidylglycerol biosynthetic process (GO:0006655)2.30850262
191apoptotic process involved in morphogenesis (GO:0060561)2.30630664
192response to type I interferon (GO:0034340)2.30443942
193regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.29650181
194maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.28025634
195cellular response to type I interferon (GO:0071357)2.27663876
196type I interferon signaling pathway (GO:0060337)2.27663876
197regulation of mast cell degranulation (GO:0043304)2.27375036
198regulation of regulated secretory pathway (GO:1903305)2.27227914

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.57686976
2VDR_21846776_ChIP-Seq_THP-1_Human3.14317693
3LXR_22292898_ChIP-Seq_THP-1_Human3.06978247
4GBX2_23144817_ChIP-Seq_PC3_Human3.03367769
5REST_21632747_ChIP-Seq_MESCs_Mouse3.03113635
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.99554010
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.95079583
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.72607237
9MYC_22102868_ChIP-Seq_BL_Human2.69764895
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.68387236
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.53434410
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.52191457
13REST_18959480_ChIP-ChIP_MESCs_Mouse2.50851997
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.36280528
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.34198822
16TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.26955336
17CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.23762249
18KDM2B_26808549_Chip-Seq_DND41_Human2.22960863
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.22599609
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.15177731
21TCF7_22412390_ChIP-Seq_EML_Mouse2.15078502
22TP63_17297297_ChIP-ChIP_HaCaT_Human2.13752694
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.09538361
24RARG_19884340_ChIP-ChIP_MEFs_Mouse2.09056804
25RACK7_27058665_Chip-Seq_MCF-7_Human2.06459453
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.03576222
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.02533677
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97890658
29P68_20966046_ChIP-Seq_HELA_Human1.96510212
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.96174605
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.88435570
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.88372303
33* VDR_24763502_ChIP-Seq_THP-1_Human1.84934140
34MAF_26560356_Chip-Seq_TH1_Human1.80337815
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.77802782
36* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77641636
37TET1_21451524_ChIP-Seq_MESCs_Mouse1.77515822
38JARID2_20064375_ChIP-Seq_MESCs_Mouse1.77165679
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.75036590
40UTX_26944678_Chip-Seq_JUKART_Human1.74657029
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.74459030
42KDM2B_26808549_Chip-Seq_K562_Human1.72713510
43* SMC4_20622854_ChIP-Seq_HELA_Human1.71555581
44SA1_27219007_Chip-Seq_ERYTHROID_Human1.70775506
45ZNF274_21170338_ChIP-Seq_K562_Hela1.67923923
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.65217064
47ELF1_20517297_ChIP-Seq_JURKAT_Human1.64644907
48DROSHA_22980978_ChIP-Seq_HELA_Human1.63956659
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63869800
50SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.63725743
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.63678629
52MAF_26560356_Chip-Seq_TH2_Human1.63492754
53CTCF_27219007_Chip-Seq_ERYTHROID_Human1.63165277
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.61504939
55ZFP281_18757296_ChIP-ChIP_E14_Mouse1.60945821
56BCL6_27268052_Chip-Seq_Bcells_Human1.60784732
57MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.60449210
58SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.60258096
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.59941156
60RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.59023272
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58736568
62BCOR_27268052_Chip-Seq_Bcells_Human1.57677571
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.57650608
64DNAJC2_21179169_ChIP-ChIP_NT2_Human1.56598398
65RUNX1_22412390_ChIP-Seq_EML_Mouse1.55525999
66SMAD4_21799915_ChIP-Seq_A2780_Human1.54110957
67RNF2_27304074_Chip-Seq_ESCs_Mouse1.51960271
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51938668
69GATA1_26923725_Chip-Seq_HPCs_Mouse1.51551237
70SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.51541881
71KDM2B_26808549_Chip-Seq_JURKAT_Human1.51363266
72SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50533049
73EZH2_27304074_Chip-Seq_ESCs_Mouse1.50217715
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46567594
75* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.45510474
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45004692
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43578900
78* CREB1_26743006_Chip-Seq_LNCaP_Human1.43470745
79EZH2_18974828_ChIP-Seq_MESCs_Mouse1.43249869
80RNF2_18974828_ChIP-Seq_MESCs_Mouse1.43249869
81SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.42691373
82SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41840708
83SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39459211
84UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38584997
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38228071
86ESR2_21235772_ChIP-Seq_MCF-7_Human1.37825172
87SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.37504210
88MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.37365446
89CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37153156
90TAF15_26573619_Chip-Seq_HEK293_Human1.36624528
91RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.36312527
92CTCF_27219007_Chip-Seq_Bcells_Human1.34916533
93ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.34415864
94MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.34185484
95GATA1_19941827_ChIP-Seq_MEL_Mouse1.33822998
96SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.33224323
97ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32613917
98* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31655912
99RNF2_27304074_Chip-Seq_NSC_Mouse1.30330081
100PU.1_20513432_ChIP-Seq_Bcells_Mouse1.26535687
101* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.26480598
102PHF8_20622854_ChIP-Seq_HELA_Human1.25093821
103BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25029803
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24631898
105GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24490689
106EED_16625203_ChIP-ChIP_MESCs_Mouse1.23786331
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23372370
108RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23346819
109BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22680219
110NCOR1_26117541_ChIP-Seq_K562_Human1.21943276
111TP63_22573176_ChIP-Seq_HFKS_Human1.20986037
112SMAD_19615063_ChIP-ChIP_OVARY_Human1.20970855
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20671918
114* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19722154
115STAT3_23295773_ChIP-Seq_U87_Human1.19571543
116ERG_21242973_ChIP-ChIP_JURKAT_Human1.18113459
117CTCF_26484167_Chip-Seq_Bcells_Mouse1.18045187
118ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17853246
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17692906
120SA1_27219007_Chip-Seq_Bcells_Human1.17499364
121KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16374370
122SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14175091
123TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13776478
124TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13431289
125SOX2_21211035_ChIP-Seq_LN229_Gbm1.13372137
126* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13286842
127E2F1_20622854_ChIP-Seq_HELA_Human1.13207400
128STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13146369
129RUNX1_27514584_Chip-Seq_MCF-7_Human1.13054082
130AR_25329375_ChIP-Seq_VCAP_Human1.12448566
131SPI1_23127762_ChIP-Seq_K562_Human1.11843383
132RARB_24833708_ChIP-Seq_LIVER_Mouse1.11499211
133NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10355036
134TP53_22127205_ChIP-Seq_IMR90_Human1.09684581
135TCF4_23295773_ChIP-Seq_U87_Human1.09112709
136ETS1_21867929_ChIP-Seq_TH2_Mouse1.08432066
137CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.08295491
138SCL_19346495_ChIP-Seq_HPC-7_Human1.07882878
139NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07130198
140PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06735429
141CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06285815
142P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06257546
143DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06124787
144KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06114389
145CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05877666
146VDR_22108803_ChIP-Seq_LS180_Human1.05088997
147CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04788727
148CTCF_21964334_ChIP-Seq_BJAB-B_Human1.04740038
149P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04261335
150ZNF263_19887448_ChIP-Seq_K562_Human1.04099800
151MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.03628279
152SMAD3_21741376_ChIP-Seq_ESCs_Human1.02338889
153WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01294994
154RARA_24833708_ChIP-Seq_LIVER_Mouse1.01289975
155P300_19829295_ChIP-Seq_ESCs_Human1.00273316
156RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99691502
157CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99245408
158SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99022372
159MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98825256
160CTCF_21964334_Chip-Seq_Bcells_Human0.98658664
161* TET1_21490601_ChIP-Seq_MESCs_Mouse0.98201424
162AR_19668381_ChIP-Seq_PC3_Human0.97224832
163YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96806844
164POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96051005
165TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96051005
166TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95271349
167MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.94711210
168IGF1R_20145208_ChIP-Seq_DFB_Human0.94287479
169BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93931590
170SOX9_26525672_Chip-Seq_HEART_Mouse0.93438882
171SMAD3_21741376_ChIP-Seq_EPCs_Human0.92439729
172POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90950995
173CBX2_27304074_Chip-Seq_ESCs_Mouse0.90129896
174FLI1_27457419_Chip-Seq_LIVER_Mouse0.89850012
175* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89463106
176TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89169798
177PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88723431
178FUS_26573619_Chip-Seq_HEK293_Human0.86497436
179FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.85878402
180RUNX2_22187159_ChIP-Seq_PCA_Human0.85525803
181ELK4_26923725_Chip-Seq_MESODERM_Mouse0.83997084
182AR_21572438_ChIP-Seq_LNCaP_Human0.83369279
183PRDM14_20953172_ChIP-Seq_ESCs_Human0.83200522
184CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82932297
185THAP11_20581084_ChIP-Seq_MESCs_Mouse0.82836328
186UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81184507
187TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.80877676
188AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80535807
189EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.80371404
190E2F1_17053090_ChIP-ChIP_MCF-7_Human0.80268338
191CBP_20019798_ChIP-Seq_JUKART_Human0.79764129

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.79520683
2MP0003880_abnormal_central_pattern3.45674357
3MP0003436_decreased_susceptibility_to3.39343720
4MP0003635_abnormal_synaptic_transmissio3.32522341
5MP0004270_analgesia3.17746950
6MP0003303_peritoneal_inflammation3.15577816
7MP0005058_abnormal_lysosome_morphology3.10235840
8MP0002822_catalepsy3.02818720
9MP0008877_abnormal_DNA_methylation2.79457672
10MP0002736_abnormal_nociception_after2.78350818
11MP0002063_abnormal_learning/memory/cond2.75812543
12MP0001968_abnormal_touch/_nociception2.74620523
13MP0003787_abnormal_imprinting2.71378918
14MP0009745_abnormal_behavioral_response2.66305360
15MP0009046_muscle_twitch2.49014539
16MP0002064_seizures2.45555222
17MP0002734_abnormal_mechanical_nocicepti2.35130138
18MP0002653_abnormal_ependyma_morphology2.33816816
19MP0003705_abnormal_hypodermis_morpholog2.32802733
20MP0003172_abnormal_lysosome_physiology2.32516869
21MP0002572_abnormal_emotion/affect_behav2.32202781
22MP0003763_abnormal_thymus_physiology2.28815323
23MP0005451_abnormal_body_composition2.27798830
24MP0010386_abnormal_urinary_bladder2.23396976
25MP0009278_abnormal_bone_marrow2.15749300
26MP0001790_abnormal_immune_system2.14488285
27MP0005387_immune_system_phenotype2.14488285
28MP0000685_abnormal_immune_system2.14264012
29MP0009780_abnormal_chondrocyte_physiolo2.12376907
30MP0010155_abnormal_intestine_physiology2.12090953
31MP0001835_abnormal_antigen_presentation2.11726702
32MP0004947_skin_inflammation2.08437936
33MP0003183_abnormal_peptide_metabolism2.08348254
34MP0005025_abnormal_response_to2.04014501
35MP0005000_abnormal_immune_tolerance2.00554130
36MP0001800_abnormal_humoral_immune1.99920798
37MP0001529_abnormal_vocalization1.99756543
38MP0002909_abnormal_adrenal_gland1.99394136
39MP0009840_abnormal_foam_cell1.96124606
40MP0001849_ear_inflammation1.96096115
41MP0002272_abnormal_nervous_system1.92397510
42MP0005646_abnormal_pituitary_gland1.89484372
43MP0000465_gastrointestinal_hemorrhage1.89350892
44MP0003300_gastrointestinal_ulcer1.84549292
45MP0005423_abnormal_somatic_nervous1.79185060
46MP0002733_abnormal_thermal_nociception1.78138883
47MP0003724_increased_susceptibility_to1.78056167
48MP0002419_abnormal_innate_immunity1.78017513
49MP0001984_abnormal_olfaction1.77461196
50MP0003879_abnormal_hair_cell1.77118126
51MP0003123_paternal_imprinting1.77063774
52MP0001501_abnormal_sleep_pattern1.73967727
53MP0002735_abnormal_chemical_nociception1.73424557
54MP0002420_abnormal_adaptive_immunity1.72425272
55MP0001819_abnormal_immune_cell1.71894648
56MP0001486_abnormal_startle_reflex1.71856213
57MP0005671_abnormal_response_to1.71789068
58MP0002723_abnormal_immune_serum1.69668569
59MP0001440_abnormal_grooming_behavior1.69278474
60MP0003191_abnormal_cellular_cholesterol1.69261055
61MP0002452_abnormal_antigen_presenting1.69197128
62MP0002067_abnormal_sensory_capabilities1.69112114
63MP0001970_abnormal_pain_threshold1.66725335
64MP0000858_altered_metastatic_potential1.60785779
65MP0002184_abnormal_innervation1.59969360
66MP0004858_abnormal_nervous_system1.59332540
67MP0001533_abnormal_skeleton_physiology1.56568875
68MP0006276_abnormal_autonomic_nervous1.56403059
69MP0003283_abnormal_digestive_organ1.52592690
70MP0000751_myopathy1.52552889
71MP0002557_abnormal_social/conspecific_i1.51489825
72MP0003122_maternal_imprinting1.49934121
73MP0005410_abnormal_fertilization1.49656970
74MP0005409_darkened_coat_color1.48780889
75MP0005386_behavior/neurological_phenoty1.48357837
76MP0004924_abnormal_behavior1.48357837
77MP0000678_abnormal_parathyroid_gland1.44569236
78MP0004811_abnormal_neuron_physiology1.44338362
79MP0003866_abnormal_defecation1.44125287
80MP0003279_aneurysm1.42420933
81MP0001873_stomach_inflammation1.39523743
82MP0008569_lethality_at_weaning1.37504977
83MP0005076_abnormal_cell_differentiation1.37454118
84MP0004510_myositis1.37195994
85MP0002398_abnormal_bone_marrow1.36948303
86MP0000716_abnormal_immune_system1.36357258
87MP0005464_abnormal_platelet_physiology1.35660023
88MP0005645_abnormal_hypothalamus_physiol1.33461912
89MP0000013_abnormal_adipose_tissue1.31358707
90MP0008004_abnormal_stomach_pH1.29650496
91MP0001188_hyperpigmentation1.29045901
92MP0001664_abnormal_digestion1.26811920
93MP0000604_amyloidosis1.25756239
94MP0003453_abnormal_keratinocyte_physiol1.25491351
95MP0003698_abnormal_male_reproductive1.22874819
96MP0000778_abnormal_nervous_system1.22421379
97MP0000955_abnormal_spinal_cord1.21386088
98MP0000490_abnormal_crypts_of1.19335357
99MP0003121_genomic_imprinting1.16547924
100MP0002066_abnormal_motor_capabilities/c1.14523636
101MP0009333_abnormal_splenocyte_physiolog1.13640102
102MP0000003_abnormal_adipose_tissue1.12872944
103MP0002998_abnormal_bone_remodeling1.12807542
104MP0003075_altered_response_to1.12395342
105MP0003091_abnormal_cell_migration1.12037564
106MP0002148_abnormal_hypersensitivity_rea1.11420298
107MP0004043_abnormal_pH_regulation1.11349425
108MP0002429_abnormal_blood_cell1.11134462
109MP0001845_abnormal_inflammatory_respons1.10926150
110MP0001502_abnormal_circadian_rhythm1.09804521
111MP0001348_abnormal_lacrimal_gland1.06851969
112MP0002722_abnormal_immune_system1.06530118
113MP0005166_decreased_susceptibility_to1.06342792
114MP0004233_abnormal_muscle_weight1.06181916
115MP0002882_abnormal_neuron_morphology1.06139767
116MP0001663_abnormal_digestive_system1.05969491
117MP0002933_joint_inflammation1.05150472
118MP0002249_abnormal_larynx_morphology1.05070612
119MP0005666_abnormal_adipose_tissue1.04739249
120MP0001929_abnormal_gametogenesis1.04693578
121MP0005375_adipose_tissue_phenotype1.04497670
122MP0009785_altered_susceptibility_to1.04239073
123MP0002405_respiratory_system_inflammati1.02926522
124MP0003566_abnormal_cell_adhesion1.02078531
125MP0000703_abnormal_thymus_morphology1.01300936
126MP0010234_abnormal_vibrissa_follicle0.99816448
127MP0005310_abnormal_salivary_gland0.99640810
128MP0002152_abnormal_brain_morphology0.98785284
129MP0008874_decreased_physiological_sensi0.97804456
130MP0001986_abnormal_taste_sensitivity0.95519463
131MP0000689_abnormal_spleen_morphology0.95332714
132MP0005501_abnormal_skin_physiology0.95029234
133MP0002796_impaired_skin_barrier0.94606439
134MP0001958_emphysema0.94577629
135MP0001905_abnormal_dopamine_level0.94126982
136MP0004185_abnormal_adipocyte_glucose0.93028628
137MP0002638_abnormal_pupillary_reflex0.92984853
138MP0002693_abnormal_pancreas_physiology0.92822156
139MP0003646_muscle_fatigue0.92126558
140MP0001765_abnormal_ion_homeostasis0.91457690
141MP0008260_abnormal_autophagy0.90999655
142MP0003690_abnormal_glial_cell0.90442573
143MP0005381_digestive/alimentary_phenotyp0.89285332
144MP0000681_abnormal_thyroid_gland0.89132015
145MP0000631_abnormal_neuroendocrine_gland0.86952197
146MP0002837_dystrophic_cardiac_calcinosis0.85253949
147MP0004264_abnormal_extraembryonic_tissu0.84949636
148MP0003329_amyloid_beta_deposits0.84505949
149MP0002069_abnormal_eating/drinking_beha0.84141193
150MP0006072_abnormal_retinal_apoptosis0.83856730
151MP0005390_skeleton_phenotype0.83626905
152MP0004036_abnormal_muscle_relaxation0.83457745
153MP0004381_abnormal_hair_follicle0.81346820
154MP0005499_abnormal_olfactory_system0.81324779
155MP0005394_taste/olfaction_phenotype0.81324779
156MP0004145_abnormal_muscle_electrophysio0.81221156
157MP0003631_nervous_system_phenotype0.80883271
158MP0000462_abnormal_digestive_system0.80805661
159MP0002161_abnormal_fertility/fecundity0.79934793
160MP0008469_abnormal_protein_level0.79321667
161MP0001545_abnormal_hematopoietic_system0.79124125
162MP0005397_hematopoietic_system_phenotyp0.79124125
163MP0009384_cardiac_valve_regurgitation0.78729274
164MP0004130_abnormal_muscle_cell0.78317781
165MP0002210_abnormal_sex_determination0.77615753
166MP0004084_abnormal_cardiac_muscle0.75518937
167MP0003633_abnormal_nervous_system0.74872660
168MP0005379_endocrine/exocrine_gland_phen0.74305356
169MP0002877_abnormal_melanocyte_morpholog0.72432672
170MP0008961_abnormal_basal_metabolism0.72207752
171MP0002089_abnormal_postnatal_growth/wei0.72198485
172MP0000477_abnormal_intestine_morphology0.71215572
173MP0001944_abnormal_pancreas_morphology0.70942228
174MP0001145_abnormal_male_reproductive0.70857539
175MP0000653_abnormal_sex_gland0.70241729
176MP0002229_neurodegeneration0.69480134
177MP0004142_abnormal_muscle_tone0.68489362
178MP0003632_abnormal_nervous_system0.68425405
179MP0004147_increased_porphyrin_level0.68377294
180MP0008872_abnormal_physiological_respon0.67609016
181MP0004885_abnormal_endolymph0.66470880
182MP0005551_abnormal_eye_electrophysiolog0.66403861
183MP0003119_abnormal_digestive_system0.65542557

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.77634532
2Epileptic encephalopathy (HP:0200134)4.52513557
3Myokymia (HP:0002411)4.31783787
4Atonic seizures (HP:0010819)4.28677546
5Focal seizures (HP:0007359)4.13990758
6Eczematoid dermatitis (HP:0000976)4.01958863
7Visual hallucinations (HP:0002367)3.99473167
8Bundle branch block (HP:0011710)3.75966794
9Febrile seizures (HP:0002373)3.67644975
10Type II lissencephaly (HP:0007260)3.58364868
11Colitis (HP:0002583)3.56006065
12Agammaglobulinemia (HP:0004432)3.45503504
13Absence seizures (HP:0002121)3.33882901
14Cellulitis (HP:0100658)3.32660462
15Nasal polyposis (HP:0100582)3.31994664
16Obstructive sleep apnea (HP:0002870)3.31942503
17Cerebellar dysplasia (HP:0007033)3.31404392
18Abnormality of the nasal mucosa (HP:0000433)3.27669618
19Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.11220245
20Generalized tonic-clonic seizures (HP:0002069)3.02530563
21Increased IgE level (HP:0003212)2.96676861
22Gastrointestinal inflammation (HP:0004386)2.93489152
23Poor eye contact (HP:0000817)2.88941445
24Gastrointestinal stroma tumor (HP:0100723)2.86843821
25Dialeptic seizures (HP:0011146)2.83605894
26Progressive cerebellar ataxia (HP:0002073)2.82862590
27Epileptiform EEG discharges (HP:0011182)2.81432139
28Dysostosis multiplex (HP:0000943)2.81286233
29Broad face (HP:0000283)2.81170171
30Centrally nucleated skeletal muscle fibers (HP:0003687)2.74045016
31Amblyopia (HP:0000646)2.72150011
32Dynein arm defect of respiratory motile cilia (HP:0012255)2.71721326
33Absent/shortened dynein arms (HP:0200106)2.71721326
34Hyperacusis (HP:0010780)2.70994469
35EEG with generalized epileptiform discharges (HP:0011198)2.69572355
36Distal upper limb amyotrophy (HP:0007149)2.69265504
37Upper limb amyotrophy (HP:0009129)2.69265504
38Inflammation of the large intestine (HP:0002037)2.68778179
39Ankle clonus (HP:0011448)2.67652877
40Chronic bronchitis (HP:0004469)2.64766791
41Thin bony cortex (HP:0002753)2.61020962
42Cerebral aneurysm (HP:0004944)2.56663343
43Hypsarrhythmia (HP:0002521)2.56174149
44Emphysema (HP:0002097)2.55764790
45Gait imbalance (HP:0002141)2.55063240
46Abnormal respiratory motile cilium physiology (HP:0012261)2.52774031
47Hemorrhage of the eye (HP:0011885)2.47903498
48Aplasia/Hypoplasia of the brainstem (HP:0007362)2.46707318
49Hypoplasia of the brainstem (HP:0002365)2.46707318
50Recurrent sinusitis (HP:0011108)2.46699070
51Abnormality of glycosaminoglycan metabolism (HP:0004371)2.45826089
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.45826089
53Abnormality of polysaccharide metabolism (HP:0011012)2.45826089
54Abnormal social behavior (HP:0012433)2.44395169
55Impaired social interactions (HP:0000735)2.44395169
56Atelectasis (HP:0100750)2.43992344
57Anterior segment dysgenesis (HP:0007700)2.42803281
58Myopathic facies (HP:0002058)2.42429406
59Mucopolysacchariduria (HP:0008155)2.41922136
60Urinary glycosaminoglycan excretion (HP:0003541)2.41922136
61Ventricular fibrillation (HP:0001663)2.41378611
62Abnormality of the lower motor neuron (HP:0002366)2.40860135
63Malnutrition (HP:0004395)2.37879592
64Recurrent bacterial skin infections (HP:0005406)2.37319472
65Infertility (HP:0000789)2.37109555
66Stridor (HP:0010307)2.36709897
67Impaired vibration sensation in the lower limbs (HP:0002166)2.36532343
68Meningitis (HP:0001287)2.36361731
69Impaired smooth pursuit (HP:0007772)2.35656284
70Congenital primary aphakia (HP:0007707)2.35034647
71Flat acetabular roof (HP:0003180)2.34357331
72Neuronal loss in central nervous system (HP:0002529)2.34064517
73Recurrent abscess formation (HP:0002722)2.33282634
74Medial flaring of the eyebrow (HP:0010747)2.33169668
75Abnormality of the labia minora (HP:0012880)2.32452980
76Mediastinal lymphadenopathy (HP:0100721)2.30892511
77Growth hormone excess (HP:0000845)2.30544778
78Abnormal hair whorl (HP:0010721)2.29282471
79Cervical subluxation (HP:0003308)2.29265516
80Gingivitis (HP:0000230)2.27510628
81Obstructive lung disease (HP:0006536)2.27471979
82Chronic obstructive pulmonary disease (HP:0006510)2.27471979
83Gaze-evoked nystagmus (HP:0000640)2.25766774
84Abnormality of macrophages (HP:0004311)2.25169435
85Distal lower limb amyotrophy (HP:0008944)2.25002961
86Nephrogenic diabetes insipidus (HP:0009806)2.23498575
87Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.22854859
88Distal lower limb muscle weakness (HP:0009053)2.21771736
89Depression (HP:0000716)2.21640614
90Lissencephaly (HP:0001339)2.21317891
91Delusions (HP:0000746)2.20211553
92J-shaped sella turcica (HP:0002680)2.19438662
93Hand muscle atrophy (HP:0009130)2.19127362
94Easy fatigability (HP:0003388)2.18719984
95Rhinitis (HP:0012384)2.16549863
96Interstitial pulmonary disease (HP:0006530)2.15795981
97Recurrent otitis media (HP:0000403)2.15484482
98Protruding tongue (HP:0010808)2.14232825
99Resting tremor (HP:0002322)2.11363548
100Buphthalmos (HP:0000557)2.10308354
101Abnormality of ocular smooth pursuit (HP:0000617)2.09762615
102Hyperventilation (HP:0002883)2.09202110
103Abnormal ciliary motility (HP:0012262)2.08179872
104Verrucae (HP:0200043)2.06979027
105Papilloma (HP:0012740)2.06979027
106Hypertensive crisis (HP:0100735)2.05903308
107Vertebral compression fractures (HP:0002953)2.05889862
108Exercise-induced myalgia (HP:0003738)2.05454760
109Limb dystonia (HP:0002451)2.05187666
110Neurofibrillary tangles (HP:0002185)2.03129402
111Unsteady gait (HP:0002317)2.01646381
112Restrictive lung disease (HP:0002091)2.01533994
113Abnormal respiratory motile cilium morphology (HP:0005938)2.00571830
114Abnormal respiratory epithelium morphology (HP:0012253)2.00571830
115Poor coordination (HP:0002370)1.99732076
116Asymmetric septal hypertrophy (HP:0001670)1.99122963
117Annular pancreas (HP:0001734)1.99078594
118Insulin-resistant diabetes mellitus (HP:0000831)1.98692080
119Recurrent fungal infections (HP:0002841)1.97811699
120Severe muscular hypotonia (HP:0006829)1.97284778
121Male infertility (HP:0003251)1.97025852
122Thoracic kyphosis (HP:0002942)1.96873128
123Increased connective tissue (HP:0009025)1.95999660
124Polygenic inheritance (HP:0010982)1.95316418
125Hemiparesis (HP:0001269)1.94993576
126Panhypogammaglobulinemia (HP:0003139)1.93749054
127Retinal dysplasia (HP:0007973)1.93456108
128Intellectual disability, profound (HP:0002187)1.91468431
129Urinary bladder sphincter dysfunction (HP:0002839)1.89038027
130Increased variability in muscle fiber diameter (HP:0003557)1.88963690
131Abnormality of the thoracic spine (HP:0100711)1.88787920
132Truncal ataxia (HP:0002078)1.88635426
133Purpura (HP:0000979)1.86773670
134Seborrheic dermatitis (HP:0001051)1.86378268
135Anxiety (HP:0000739)1.85820874
136Bradykinesia (HP:0002067)1.85603045
137Abnormality of glycolipid metabolism (HP:0010969)1.85436105
138Abnormality of liposaccharide metabolism (HP:0010968)1.85436105
139Abnormality of glycosphingolipid metabolism (HP:0004343)1.85436105
140Cerebral inclusion bodies (HP:0100314)1.84758191
141Ependymoma (HP:0002888)1.84419994
142Papilledema (HP:0001085)1.84209220
143Open mouth (HP:0000194)1.83855683
144Recurrent viral infections (HP:0004429)1.83607366
145Ragged-red muscle fibers (HP:0003200)1.83404081
146Joint stiffness (HP:0001387)1.81105930
147Hypoplasia of the pons (HP:0012110)1.81091053
148Recurrent bronchitis (HP:0002837)1.80931409
149Oligomenorrhea (HP:0000876)1.80809932
150Cortical visual impairment (HP:0100704)1.80489170
151Osteomyelitis (HP:0002754)1.80070610
152Premature loss of primary teeth (HP:0006323)1.79797496
153Inability to walk (HP:0002540)1.79220001
154Systemic lupus erythematosus (HP:0002725)1.79165533
155Action tremor (HP:0002345)1.78682193
156Neoplasm of the peripheral nervous system (HP:0100007)1.78627337
157Polyphagia (HP:0002591)1.77607778
158Ulnar bowing (HP:0003031)1.77595357
159Achilles tendon contracture (HP:0001771)1.77588433
160Broad-based gait (HP:0002136)1.76757300
161Supranuclear gaze palsy (HP:0000605)1.76741283
162Recurrent gram-negative bacterial infections (HP:0005420)1.75129741
163Poor suck (HP:0002033)1.75075411
164Myositis (HP:0100614)1.74572277
165Difficulty climbing stairs (HP:0003551)1.74487087
166Abnormal eating behavior (HP:0100738)1.74333022
167Loss of speech (HP:0002371)1.74262485
168Specific learning disability (HP:0001328)1.74163650
169Progressive inability to walk (HP:0002505)1.72728132
170Shoulder girdle muscle weakness (HP:0003547)1.72302083
171Fetal akinesia sequence (HP:0001989)1.71757609
172Sepsis (HP:0100806)1.70799426
173Molar tooth sign on MRI (HP:0002419)1.70758947
174Abnormality of midbrain morphology (HP:0002418)1.70758947
175Neuroendocrine neoplasm (HP:0100634)1.70569146
176Pustule (HP:0200039)1.70401569
177Short tibia (HP:0005736)1.70317154
178Congenital glaucoma (HP:0001087)1.69999993
179Turricephaly (HP:0000262)1.69997432
180Broad distal phalanx of finger (HP:0009836)1.69942987
181Aneurysm (HP:0002617)1.69842774
182Metaphyseal cupping (HP:0003021)1.69418517
183Progressive sensorineural hearing impairment (HP:0000408)1.69255512
184Abnormality of skeletal muscle fiber size (HP:0012084)1.68937171
185Abnormality of the astrocytes (HP:0100707)1.68550022
186Astrocytoma (HP:0009592)1.68550022
187Biliary tract neoplasm (HP:0100574)1.68153707
188Flattened epiphyses (HP:0003071)1.68115025
189Torticollis (HP:0000473)1.67753178
190Peripheral hypomyelination (HP:0007182)1.67610024
191Bulbar palsy (HP:0001283)1.65951639
192Gastrointestinal dysmotility (HP:0002579)1.65170268
193Impaired vibratory sensation (HP:0002495)1.64441955
194Diplopia (HP:0000651)1.64392532
195Abnormality of binocular vision (HP:0011514)1.64392532
196Testicular neoplasm (HP:0010788)1.64151403
197Urinary urgency (HP:0000012)1.62974599

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.22729195
2MAP3K93.60314062
3CASK3.50600553
4NTRK33.44093649
5PIK3CG3.27674063
6ERN13.27396317
7MAP3K43.19847083
8PRKD33.10199938
9EPHA42.85062195
10MAP4K12.76800914
11MAP3K122.55493261
12MAP2K72.51491721
13AKT32.51353623
14ARAF2.43278071
15TESK22.31178033
16DAPK22.29637881
17KSR22.17846985
18SIK12.12550989
19SMG12.10964887
20RIPK12.07300847
21BRAF2.01528815
22CCNB11.97607277
23EEF2K1.89083378
24MAP3K101.85874887
25MARK11.83080347
26MINK11.82701108
27RIPK41.80543202
28DAPK11.77680670
29NTRK11.77214169
30TNK21.72074215
31MAP3K111.71479255
32TSSK61.67722000
33KSR11.67702570
34NEK11.66668360
35MARK21.64218780
36TYK21.63765598
37TBK11.60967376
38PDK31.60771554
39PDK41.60771554
40GRK61.60367916
41PAK61.58302956
42EPHB11.56775724
43MAPK151.56588081
44MAP2K41.50552507
45PRKD21.49450259
46FGFR41.47931331
47SIK21.46483993
48PLK21.45832018
49NME11.45511742
50BLK1.40949207
51NTRK21.39082832
52CDK191.37472588
53ZAP701.32789052
54FES1.25955114
55MAP2K31.22768632
56PKN21.16896203
57MAPK131.13341068
58CAMKK11.09340001
59CDK121.07481581
60MAP3K21.04718437
61CDK51.04460549
62MAP2K21.04275808
63PNCK1.02687884
64GRK50.99571023
65MAP3K140.99245400
66PTK60.98915099
67FRK0.98671602
68PDK20.96329748
69PTK2B0.95978962
70BTK0.95852345
71IKBKE0.95695828
72MAPK120.95432524
73NME20.93829663
74PRKCG0.93136563
75RAF10.91439126
76CSK0.86993539
77STK380.85930683
78PRPF4B0.85207062
79JAK30.85131863
80IRAK40.84796015
81MAP3K70.83027723
82KDR0.81020538
83RET0.79733166
84MAP3K130.79142368
85TESK10.78837801
86TAOK20.78096165
87SGK20.77308448
88MAPK70.77008113
89HCK0.76289921
90RPS6KL10.76070684
91RPS6KC10.76070684
92CDK180.76053450
93IRAK30.75657380
94CDC42BPA0.74955428
95RPS6KA20.74887619
96DYRK1B0.74648196
97BMPR1B0.74171111
98INSRR0.73207404
99JAK10.73181281
100CSF1R0.73089147
101MAP3K30.72734156
102TTN0.72626871
103SGK2230.72609710
104SGK4940.72609710
105SYK0.70769744
106MAP2K10.70507712
107CDK150.70077541
108BRSK10.68340739
109BMX0.67975260
110CAMK2A0.65079202
111STK38L0.64402774
112LRRK20.62529893
113BMPR20.62429279
114DYRK1A0.61595323
115LMTK20.61071740
116MATK0.60792953
117CDK11A0.60735481
118MAPK110.59860469
119MST1R0.58903873
120CDK140.58814051
121RPS6KA60.57037966
122TYRO30.56285670
123PINK10.54863513
124BUB10.54546623
125MAPK40.53238753
126HIPK20.53106809
127LYN0.52991597
128LATS20.52509548
129MAPKAPK30.51304762
130TAOK10.50998932
131PRKD10.50960889
132DAPK30.50678510
133PASK0.50187826
134FGR0.50073941
135MAP3K10.49006366
136FYN0.48992544
137MTOR0.48610031
138LCK0.48562347
139DDR20.48193813
140CAMKK20.48079145
141WNK40.47595383
142CDK40.47281224
143PDGFRA0.46610093
144SCYL20.46390277
145FER0.46259747
146PIM20.45886202
147SIK30.45395590
148PLK30.44792814
149PRKCI0.43914204
150MAP3K60.43858446
151ITK0.43625200
152JAK20.43291174
153CAMK2B0.42966641
154PRKCE0.42949185
155PRKCH0.42918909
156MAP2K60.42214851
157NEK20.42155223
158KIT0.42077830
159PAK30.41555747
160OXSR10.41007164
161UHMK10.40440216
162SGK30.40142796
163IKBKB0.39389706
164ICK0.39058176
165PRKG20.38810364
166EPHA30.37807900
167EPHA20.36743222
168PDPK10.36373183
169WNK30.34508728
170SGK10.34339933
171ADRBK10.32106617
172STK160.30933533
173PDK10.30799554
174CDK80.30364394
175TTK0.29958690
176STK110.29878248

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.58211833
2Other glycan degradation_Homo sapiens_hsa005113.08107386
3Nicotine addiction_Homo sapiens_hsa050332.88771292
4Collecting duct acid secretion_Homo sapiens_hsa049662.40139607
5Olfactory transduction_Homo sapiens_hsa047402.35414775
6Long-term potentiation_Homo sapiens_hsa047202.34305255
7Amphetamine addiction_Homo sapiens_hsa050312.34243328
8B cell receptor signaling pathway_Homo sapiens_hsa046622.34173495
9Insulin secretion_Homo sapiens_hsa049112.30448758
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.20963871
11Cyanoamino acid metabolism_Homo sapiens_hsa004602.18077718
12Circadian entrainment_Homo sapiens_hsa047132.11022684
13Vibrio cholerae infection_Homo sapiens_hsa051101.98910506
14GABAergic synapse_Homo sapiens_hsa047271.96240057
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.93646871
16Dopaminergic synapse_Homo sapiens_hsa047281.93478557
17Morphine addiction_Homo sapiens_hsa050321.92500030
18Acute myeloid leukemia_Homo sapiens_hsa052211.85900620
19Notch signaling pathway_Homo sapiens_hsa043301.81874395
20Primary immunodeficiency_Homo sapiens_hsa053401.81003827
21Salivary secretion_Homo sapiens_hsa049701.75466736
22Taste transduction_Homo sapiens_hsa047421.74662532
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.74125054
24Glutamatergic synapse_Homo sapiens_hsa047241.71739182
25Leishmaniasis_Homo sapiens_hsa051401.68870384
26Osteoclast differentiation_Homo sapiens_hsa043801.67072352
27Cholinergic synapse_Homo sapiens_hsa047251.65207786
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.64345353
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.62219809
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.61348830
31Type II diabetes mellitus_Homo sapiens_hsa049301.56391787
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.56383804
33Cocaine addiction_Homo sapiens_hsa050301.53183560
34Gastric acid secretion_Homo sapiens_hsa049711.43311804
35Allograft rejection_Homo sapiens_hsa053301.43024733
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.41885669
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41203828
38Renin secretion_Homo sapiens_hsa049241.40992551
39Oocyte meiosis_Homo sapiens_hsa041141.40785389
40Estrogen signaling pathway_Homo sapiens_hsa049151.40754112
41Oxytocin signaling pathway_Homo sapiens_hsa049211.38881142
42Autoimmune thyroid disease_Homo sapiens_hsa053201.35972510
43Serotonergic synapse_Homo sapiens_hsa047261.35249227
44Long-term depression_Homo sapiens_hsa047301.34005824
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32553721
46Pancreatic secretion_Homo sapiens_hsa049721.32473009
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.32117722
48Intestinal immune network for IgA production_Homo sapiens_hsa046721.31802732
49Graft-versus-host disease_Homo sapiens_hsa053321.31203113
50Gap junction_Homo sapiens_hsa045401.29973425
51Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26915481
52Chronic myeloid leukemia_Homo sapiens_hsa052201.25954790
53Calcium signaling pathway_Homo sapiens_hsa040201.25169021
54Viral myocarditis_Homo sapiens_hsa054161.24089909
55GnRH signaling pathway_Homo sapiens_hsa049121.21524675
56Toxoplasmosis_Homo sapiens_hsa051451.20702291
57Tuberculosis_Homo sapiens_hsa051521.19458677
58Glioma_Homo sapiens_hsa052141.19299941
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18213187
60Leukocyte transendothelial migration_Homo sapiens_hsa046701.17253107
61Hepatitis C_Homo sapiens_hsa051601.16085081
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12598057
63ErbB signaling pathway_Homo sapiens_hsa040121.11318624
64Staphylococcus aureus infection_Homo sapiens_hsa051501.10182243
65Inositol phosphate metabolism_Homo sapiens_hsa005621.09664945
66Lysosome_Homo sapiens_hsa041421.07430431
67Carbohydrate digestion and absorption_Homo sapiens_hsa049731.05786055
68T cell receptor signaling pathway_Homo sapiens_hsa046601.05019326
69Endocytosis_Homo sapiens_hsa041441.03299827
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.02260423
71Influenza A_Homo sapiens_hsa051641.01240646
72Circadian rhythm_Homo sapiens_hsa047100.97938211
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96906132
74Asthma_Homo sapiens_hsa053100.96270591
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95073458
76cAMP signaling pathway_Homo sapiens_hsa040240.95038052
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94943548
78TNF signaling pathway_Homo sapiens_hsa046680.94024380
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93564544
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92752947
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.92545256
82mTOR signaling pathway_Homo sapiens_hsa041500.92336553
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.91242416
84Type I diabetes mellitus_Homo sapiens_hsa049400.91197865
85Pancreatic cancer_Homo sapiens_hsa052120.91039137
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90865741
87Antigen processing and presentation_Homo sapiens_hsa046120.89076594
88Endometrial cancer_Homo sapiens_hsa052130.86622641
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.86304034
90Shigellosis_Homo sapiens_hsa051310.83983827
91Apoptosis_Homo sapiens_hsa042100.83837936
92Chemokine signaling pathway_Homo sapiens_hsa040620.81895057
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81402009
94Hepatitis B_Homo sapiens_hsa051610.81207548
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80696913
96Glucagon signaling pathway_Homo sapiens_hsa049220.79694043
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79549775
98Vitamin B6 metabolism_Homo sapiens_hsa007500.79396926
99Herpes simplex infection_Homo sapiens_hsa051680.78648482
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78613149
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78442120
102Bladder cancer_Homo sapiens_hsa052190.78222311
103Salmonella infection_Homo sapiens_hsa051320.77680201
104Galactose metabolism_Homo sapiens_hsa000520.76759689
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76340650
106Prion diseases_Homo sapiens_hsa050200.76292811
107Pertussis_Homo sapiens_hsa051330.75977169
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.75938754
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.74808077
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73955653
111Pentose phosphate pathway_Homo sapiens_hsa000300.73544235
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73526174
113Melanogenesis_Homo sapiens_hsa049160.73523657
114VEGF signaling pathway_Homo sapiens_hsa043700.72706888
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72690074
116Prolactin signaling pathway_Homo sapiens_hsa049170.70310069
117Dorso-ventral axis formation_Homo sapiens_hsa043200.69724893
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69584732
119Cardiac muscle contraction_Homo sapiens_hsa042600.69417264
120Phagosome_Homo sapiens_hsa041450.69250882
121Sulfur metabolism_Homo sapiens_hsa009200.65874323
122Thyroid hormone synthesis_Homo sapiens_hsa049180.65850938
123Regulation of autophagy_Homo sapiens_hsa041400.64741516
124Oxidative phosphorylation_Homo sapiens_hsa001900.63791435
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62557386
126Phenylalanine metabolism_Homo sapiens_hsa003600.62430547
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.62174540
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61946445
129Amoebiasis_Homo sapiens_hsa051460.61911990
130Platelet activation_Homo sapiens_hsa046110.60829754
131Choline metabolism in cancer_Homo sapiens_hsa052310.60286847
132Insulin resistance_Homo sapiens_hsa049310.60252223
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.60037693
134Fructose and mannose metabolism_Homo sapiens_hsa000510.59255187
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59042303
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58625209
137Insulin signaling pathway_Homo sapiens_hsa049100.57814460
138HTLV-I infection_Homo sapiens_hsa051660.56449319
139Non-small cell lung cancer_Homo sapiens_hsa052230.56330512
140Alcoholism_Homo sapiens_hsa050340.55247530
141Colorectal cancer_Homo sapiens_hsa052100.55182022
142Phospholipase D signaling pathway_Homo sapiens_hsa040720.54012509
143AMPK signaling pathway_Homo sapiens_hsa041520.53931580
144Hematopoietic cell lineage_Homo sapiens_hsa046400.53734106
145Viral carcinogenesis_Homo sapiens_hsa052030.51645053
146Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51180154
147Measles_Homo sapiens_hsa051620.50968427
148Renal cell carcinoma_Homo sapiens_hsa052110.49101544
149Huntingtons disease_Homo sapiens_hsa050160.48535974
150Sulfur relay system_Homo sapiens_hsa041220.45380321
151Alzheimers disease_Homo sapiens_hsa050100.43350349
152Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43206196
153MAPK signaling pathway_Homo sapiens_hsa040100.43006047
154Ras signaling pathway_Homo sapiens_hsa040140.42018975
155Rheumatoid arthritis_Homo sapiens_hsa053230.40854835
156Glycerophospholipid metabolism_Homo sapiens_hsa005640.40712838
157Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39957431
158mRNA surveillance pathway_Homo sapiens_hsa030150.39593518
159Melanoma_Homo sapiens_hsa052180.39569014
160N-Glycan biosynthesis_Homo sapiens_hsa005100.39461816
161Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39203448
162Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37172874
163Axon guidance_Homo sapiens_hsa043600.37111996
164Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.35535306
165SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35037917
166Parkinsons disease_Homo sapiens_hsa050120.33986405

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