SGTA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.69902897
2COPI coating of Golgi vesicle (GO:0048205)5.69902897
3NADH metabolic process (GO:0006734)5.17418194
4proline biosynthetic process (GO:0006561)5.12156688
5peptidyl-arginine omega-N-methylation (GO:0035247)4.56348956
6retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.43358410
7tricarboxylic acid cycle (GO:0006099)4.42331713
8protein retention in ER lumen (GO:0006621)4.40944778
9response to pheromone (GO:0019236)4.37239376
10DNA unwinding involved in DNA replication (GO:0006268)4.31461131
11protein deneddylation (GO:0000338)4.30626851
12histone arginine methylation (GO:0034969)4.30141147
13maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.25471106
14cullin deneddylation (GO:0010388)4.19219221
15nuclear envelope reassembly (GO:0031468)4.14900054
16mitotic nuclear envelope reassembly (GO:0007084)4.14900054
17regulation of mammary gland epithelial cell proliferation (GO:0033599)4.08638183
18purine nucleobase biosynthetic process (GO:0009113)4.00444700
19regulation of translational fidelity (GO:0006450)3.99235189
20negative regulation of microtubule polymerization (GO:0031115)3.98326087
21peptidyl-arginine methylation (GO:0018216)3.95332405
22peptidyl-arginine N-methylation (GO:0035246)3.95332405
23negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.93324707
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.83054399
25positive regulation of synapse maturation (GO:0090129)3.81300112
26negative regulation of cell size (GO:0045792)3.79404721
27protein maturation by protein folding (GO:0022417)3.77768016
28positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.70947385
29nucleobase biosynthetic process (GO:0046112)3.69650231
30pyrimidine nucleobase catabolic process (GO:0006208)3.68120010
31proteasome assembly (GO:0043248)3.68101848
32anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.67304788
33regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.61439067
34chaperone-mediated protein transport (GO:0072321)3.59678211
35proline metabolic process (GO:0006560)3.59675236
36L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.59082332
37negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.52859125
38negative regulation of ligase activity (GO:0051352)3.52859125
39formation of translation preinitiation complex (GO:0001731)3.41224292
40positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.36062225
41establishment of viral latency (GO:0019043)3.34426367
42positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.32949427
43nucleosome disassembly (GO:0006337)3.31562116
44protein-DNA complex disassembly (GO:0032986)3.31562116
45intracellular estrogen receptor signaling pathway (GO:0030520)3.31491101
46pentose-phosphate shunt (GO:0006098)3.30540158
47mitotic chromosome condensation (GO:0007076)3.26147692
48establishment of integrated proviral latency (GO:0075713)3.25594339
49protein complex localization (GO:0031503)3.21235027
50L-serine metabolic process (GO:0006563)3.20398452
51mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.19477135
52spliceosomal snRNP assembly (GO:0000387)3.18807559
53amino acid salvage (GO:0043102)3.17333977
54L-methionine salvage (GO:0071267)3.17333977
55L-methionine biosynthetic process (GO:0071265)3.17333977
56methionine biosynthetic process (GO:0009086)3.17117203
57misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.16885479
58protein insertion into membrane (GO:0051205)3.14485277
59de novo posttranslational protein folding (GO:0051084)3.09626390
60positive regulation of ligase activity (GO:0051351)3.09225275
61aspartate family amino acid biosynthetic process (GO:0009067)3.07311848
62glucose 6-phosphate metabolic process (GO:0051156)3.07060522
63protein localization to endosome (GO:0036010)3.06899382
64regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.04403811
65regulation of NFAT protein import into nucleus (GO:0051532)3.04216541
66regulation of ubiquitin-protein transferase activity (GO:0051438)3.01644848
67de novo protein folding (GO:0006458)3.01517002
68regulation of G0 to G1 transition (GO:0070316)3.01298938
69GDP-mannose metabolic process (GO:0019673)2.99302271
70NADPH regeneration (GO:0006740)2.98896830
71oxidative phosphorylation (GO:0006119)2.97637851
72apoptotic process involved in morphogenesis (GO:0060561)2.97172253
73DNA strand elongation involved in DNA replication (GO:0006271)2.96354456
74folic acid transport (GO:0015884)2.92961500
75regulation of early endosome to late endosome transport (GO:2000641)2.92784275
76glucose catabolic process (GO:0006007)2.92218266
774-hydroxyproline metabolic process (GO:0019471)2.92021923
78DNA strand elongation (GO:0022616)2.91963184
79UV protection (GO:0009650)2.91869907
80regulation of cellular amino acid metabolic process (GO:0006521)2.91126955
81establishment of mitochondrion localization (GO:0051654)2.89654459
823-UTR-mediated mRNA stabilization (GO:0070935)2.88645657
83regulation of translational termination (GO:0006449)2.87741770
84energy coupled proton transport, down electrochemical gradient (GO:0015985)2.87665240
85ATP synthesis coupled proton transport (GO:0015986)2.87665240
86regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.87610814
87methionine metabolic process (GO:0006555)2.86533251
88rRNA transcription (GO:0009303)2.84940617
89activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.84614315
90adherens junction assembly (GO:0034333)2.83046090
91regulation of ligase activity (GO:0051340)2.82978332
92glycolytic process (GO:0006096)2.82410231
93spliceosomal complex assembly (GO:0000245)2.82164363
94DNA replication initiation (GO:0006270)2.82099779
95barbed-end actin filament capping (GO:0051016)2.80736364
96GMP metabolic process (GO:0046037)2.80288484
97tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.79507831
98RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.79507831
99nucleobase-containing small molecule interconversion (GO:0015949)2.79467396
100galactose catabolic process (GO:0019388)2.79466185
101positive regulation of nuclease activity (GO:0032075)2.78933279
102DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.78218193
103cellular protein complex localization (GO:0034629)2.77150395
104ribosome biogenesis (GO:0042254)2.75975011
105lung-associated mesenchyme development (GO:0060484)2.74947191
106single strand break repair (GO:0000012)2.71913236
107pentose metabolic process (GO:0019321)2.70908512
108intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.68479004
109signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.68479004
110signal transduction involved in DNA integrity checkpoint (GO:0072401)2.68350118
111signal transduction involved in DNA damage checkpoint (GO:0072422)2.68350118
112negative regulation of mRNA processing (GO:0050686)2.67572376
113signal transduction involved in cell cycle checkpoint (GO:0072395)2.67524562
114activation of MAPKKK activity (GO:0000185)2.67224569
115snRNA metabolic process (GO:0016073)2.65712620
116establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.65594534
117mitochondrion transport along microtubule (GO:0047497)2.65594534
118signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.65319672
119signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.65319672
120signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.65319672
121regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.62407351
122positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.62407351
123chromosome condensation (GO:0030261)2.62214854
1247-methylguanosine mRNA capping (GO:0006370)2.61860439
125negative regulation of DNA-templated transcription, elongation (GO:0032785)2.60249902
126sulfur amino acid biosynthetic process (GO:0000097)2.59603603
127cell-substrate adherens junction assembly (GO:0007045)2.59107389
128focal adhesion assembly (GO:0048041)2.59107389
129regulation of mitochondrial translation (GO:0070129)2.58506914
130hexose biosynthetic process (GO:0019319)2.58339408
131cytoskeletal anchoring at plasma membrane (GO:0007016)2.57688068
132deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.57339116
133response to misfolded protein (GO:0051788)2.56905352
134gluconeogenesis (GO:0006094)2.56863413
135DNA deamination (GO:0045006)2.56183073
136tricarboxylic acid metabolic process (GO:0072350)2.55700018
137regulation of synapse maturation (GO:0090128)2.54148416
138ventricular cardiac muscle cell development (GO:0055015)2.53570823
139regulation of cofactor metabolic process (GO:0051193)2.53530725
140regulation of coenzyme metabolic process (GO:0051196)2.53530725
141histone H2A acetylation (GO:0043968)2.52619827
142nucleobase catabolic process (GO:0046113)2.52456049
143planar cell polarity pathway involved in neural tube closure (GO:0090179)2.50303358
144pyruvate metabolic process (GO:0006090)2.49979703
145oxaloacetate metabolic process (GO:0006107)2.49738543
146mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.48527503
147telomere maintenance via semi-conservative replication (GO:0032201)2.47319017
148activation of Rac GTPase activity (GO:0032863)2.46570294
149vesicle coating (GO:0006901)2.46288731
150synaptic vesicle docking involved in exocytosis (GO:0016081)2.45416424
151paraxial mesoderm development (GO:0048339)2.45332331
152endoplasmic reticulum unfolded protein response (GO:0030968)2.44902943
153blastocyst development (GO:0001824)2.43921399
154mitochondrial fusion (GO:0008053)2.43293990
155RNA capping (GO:0036260)2.43087212
1567-methylguanosine RNA capping (GO:0009452)2.43087212
157peptidyl-arginine modification (GO:0018195)2.42934472
158sarcomere organization (GO:0045214)2.42743822
159negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.42466648
160establishment of protein localization to mitochondrion (GO:0072655)2.42171984
161regulation of nuclease activity (GO:0032069)2.41585850
162heterochromatin organization (GO:0070828)2.41350236
163monosaccharide biosynthetic process (GO:0046364)2.41221462
164heart trabecula formation (GO:0060347)2.41034423
165spliceosomal tri-snRNP complex assembly (GO:0000244)2.40779429
166tRNA methylation (GO:0030488)2.39965074
167regulation of chromatin binding (GO:0035561)2.39920532
168transcription elongation from RNA polymerase III promoter (GO:0006385)2.39531032
169termination of RNA polymerase III transcription (GO:0006386)2.39531032
170negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.37350492
171negative regulation of mRNA metabolic process (GO:1903312)2.37280405
172regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.36725052
173negative regulation of protein ubiquitination (GO:0031397)2.36257587
174regulation of telomerase activity (GO:0051972)2.34731784
175protein targeting to mitochondrion (GO:0006626)2.34456802
176folic acid metabolic process (GO:0046655)2.33888222
177amino acid activation (GO:0043038)2.32556218

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.80408771
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.53377867
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.27837313
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.07054587
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.96459460
6* ETS1_20019798_ChIP-Seq_JURKAT_Human2.95472363
7THAP11_20581084_ChIP-Seq_MESCs_Mouse2.61845440
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.61056846
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.56392011
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.53757234
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.52533163
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.49967039
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.44049330
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.41781648
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.36040279
16* CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.32957535
17XRN2_22483619_ChIP-Seq_HELA_Human2.27590925
18MYC_22102868_ChIP-Seq_BL_Human2.23729566
19YY1_21170310_ChIP-Seq_MESCs_Mouse2.17160696
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.16000967
21VDR_21846776_ChIP-Seq_THP-1_Human2.14262970
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.12750212
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.03185090
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.96113883
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.95129247
26* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.89940528
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86913086
28ZNF263_19887448_ChIP-Seq_K562_Human1.86563319
29* GABP_19822575_ChIP-Seq_HepG2_Human1.85393192
30CIITA_25753668_ChIP-Seq_RAJI_Human1.82502232
31* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.80846455
32ZFP281_18757296_ChIP-ChIP_E14_Mouse1.78799575
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.76751450
34* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.75119538
35CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.71657536
36NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.70938197
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.70751418
38RACK7_27058665_Chip-Seq_MCF-7_Human1.63140109
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.61675310
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61406899
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60756308
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60111091
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60004197
44POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.59358631
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59207735
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57473053
47YY1_22570637_ChIP-Seq_MALME-3M_Human1.54929222
48KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.53850776
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51244374
50* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.50910214
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48446045
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48054577
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45907036
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43345695
55TTF2_22483619_ChIP-Seq_HELA_Human1.42415097
56DCP1A_22483619_ChIP-Seq_HELA_Human1.41949975
57TET1_21451524_ChIP-Seq_MESCs_Mouse1.41887875
58CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39903348
59KDM2B_26808549_Chip-Seq_DND41_Human1.39246879
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.38941619
61* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38155668
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34743732
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.34205324
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.33110191
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.33077587
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30451329
67EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.29671655
68FOXM1_23109430_ChIP-Seq_U2OS_Human1.27627147
69CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26945641
70CTCF_18555785_ChIP-Seq_MESCs_Mouse1.26422350
71TP63_17297297_ChIP-ChIP_HaCaT_Human1.26172611
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25702410
73SMC4_20622854_ChIP-Seq_HELA_Human1.25563641
74FOXP1_21924763_ChIP-Seq_HESCs_Human1.25439544
75TCF7_22412390_ChIP-Seq_EML_Mouse1.24677287
76CLOCK_20551151_ChIP-Seq_293T_Human1.24392399
77NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.23582437
78KDM2B_26808549_Chip-Seq_K562_Human1.22872602
79KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21925716
80PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21920185
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21907993
82ELF1_17652178_ChIP-ChIP_JURKAT_Human1.21482852
83P68_20966046_ChIP-Seq_HELA_Human1.21479356
84* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20142273
85OCT4_18692474_ChIP-Seq_MEFs_Mouse1.19854770
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.18287965
87CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.18155268
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17692583
89VDR_23849224_ChIP-Seq_CD4+_Human1.17690749
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17382107
91TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16391191
92SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16249727
93EGR1_19374776_ChIP-ChIP_THP-1_Human1.15611061
94* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15605202
95MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15234421
96* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.13569380
97FOXP3_21729870_ChIP-Seq_TREG_Human1.13399880
98STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13331092
99ELF1_20517297_ChIP-Seq_JURKAT_Human1.13027987
100LXR_22292898_ChIP-Seq_THP-1_Human1.12071045
101NANOG_21062744_ChIP-ChIP_HESCs_Human1.11782647
102E2F7_22180533_ChIP-Seq_HELA_Human1.10840925
103DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10740173
104BCL6_27268052_Chip-Seq_Bcells_Human1.10667863
105CREB1_26743006_Chip-Seq_LNCaP_Human1.10148455
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10114213
107FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.09931029
108CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09204030
109BCOR_27268052_Chip-Seq_Bcells_Human1.08898961
110RARA_24833708_ChIP-Seq_LIVER_Mouse1.08543731
111SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.08072349
112UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06960012
113KDM5A_27292631_Chip-Seq_BREAST_Human1.06869189
114SOX2_18692474_ChIP-Seq_MEFs_Mouse1.06175577
115SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06136795
116ATF3_27146783_Chip-Seq_COLON_Human1.05205227
117NCOR1_26117541_ChIP-Seq_K562_Human1.05110685
118TBX5_21415370_ChIP-Seq_HL-1_Mouse1.04401443
119P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03603085
120SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02604463
121RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01775226
122* PHF8_20622854_ChIP-Seq_HELA_Human1.01670308
123EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01399218
124SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00842780
125E2F1_20622854_ChIP-Seq_HELA_Human1.00689772
126NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00199172
127* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00128078
128DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99345951
129CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99286871
130TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.99051938
131ERG_21242973_ChIP-ChIP_JURKAT_Human0.97906774
132EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97862632

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition4.10673524
2MP0003705_abnormal_hypodermis_morpholog3.35636566
3MP0000751_myopathy2.89297651
4MP0002653_abnormal_ependyma_morphology2.86420616
5MP0010030_abnormal_orbit_morphology2.53650968
6MP0003646_muscle_fatigue2.44628343
7MP0004859_abnormal_synaptic_plasticity2.36828662
8MP0002877_abnormal_melanocyte_morpholog2.23537059
9MP0003693_abnormal_embryo_hatching2.22510111
10MP0003122_maternal_imprinting2.21658893
11MP0005670_abnormal_white_adipose2.21453319
12MP0000537_abnormal_urethra_morphology2.16844784
13MP0009840_abnormal_foam_cell2.11930648
14MP0003123_paternal_imprinting2.00654201
15MP0004233_abnormal_muscle_weight2.00573929
16MP0001529_abnormal_vocalization1.92965680
17MP0002837_dystrophic_cardiac_calcinosis1.90655277
18MP0000750_abnormal_muscle_regeneration1.88866367
19MP0009278_abnormal_bone_marrow1.88491189
20MP0000749_muscle_degeneration1.85684742
21MP0003111_abnormal_nucleus_morphology1.85501994
22MP0002822_catalepsy1.79150205
23MP0004957_abnormal_blastocyst_morpholog1.75059277
24MP0006138_congestive_heart_failure1.73042973
25MP0002269_muscular_atrophy1.72949875
26MP0004084_abnormal_cardiac_muscle1.69488330
27MP0000003_abnormal_adipose_tissue1.64868577
28MP0005076_abnormal_cell_differentiation1.62229923
29MP0004185_abnormal_adipocyte_glucose1.59776073
30MP0002234_abnormal_pharynx_morphology1.59617781
31MP0003329_amyloid_beta_deposits1.58561961
32MP0003119_abnormal_digestive_system1.56313351
33MP0003566_abnormal_cell_adhesion1.55192588
34MP0008007_abnormal_cellular_replicative1.53143835
35MP0004133_heterotaxia1.52823102
36MP0004036_abnormal_muscle_relaxation1.52755585
37MP0005501_abnormal_skin_physiology1.51945482
38MP0003221_abnormal_cardiomyocyte_apopto1.49121364
39MP0008260_abnormal_autophagy1.48362812
40MP0001348_abnormal_lacrimal_gland1.48227126
41MP0000350_abnormal_cell_proliferation1.47827699
42MP0001730_embryonic_growth_arrest1.46766610
43MP0000747_muscle_weakness1.45813839
44MP0005257_abnormal_intraocular_pressure1.41917961
45MP0002089_abnormal_postnatal_growth/wei1.41073531
46MP0003077_abnormal_cell_cycle1.39413994
47MP0005377_hearing/vestibular/ear_phenot1.36796990
48MP0003878_abnormal_ear_physiology1.36796990
49MP0000733_abnormal_muscle_development1.34963720
50MP0004145_abnormal_muscle_electrophysio1.32511117
51MP0006035_abnormal_mitochondrial_morpho1.31136305
52MP0000759_abnormal_skeletal_muscle1.29847047
53MP0000778_abnormal_nervous_system1.27940613
54MP0006036_abnormal_mitochondrial_physio1.27520197
55MP0003453_abnormal_keratinocyte_physiol1.27296265
56MP0005375_adipose_tissue_phenotype1.26772955
57MP0003137_abnormal_impulse_conducting1.26315300
58MP0001849_ear_inflammation1.24965869
59MP0003635_abnormal_synaptic_transmissio1.24486948
60MP0000681_abnormal_thyroid_gland1.24086238
61MP0008932_abnormal_embryonic_tissue1.23242290
62MP0002106_abnormal_muscle_physiology1.23162717
63MP0000534_abnormal_ureter_morphology1.22571473
64MP0004858_abnormal_nervous_system1.22430057
65MP0000313_abnormal_cell_death1.20343749
66MP0005330_cardiomyopathy1.19821883
67MP0004087_abnormal_muscle_fiber1.19594347
68MP0003879_abnormal_hair_cell1.19049600
69MP0005666_abnormal_adipose_tissue1.18727966
70MP0003115_abnormal_respiratory_system1.18394649
71MP0002184_abnormal_innervation1.17130197
72MP0003806_abnormal_nucleotide_metabolis1.16807244
73MP0000013_abnormal_adipose_tissue1.16337222
74MP0002063_abnormal_learning/memory/cond1.11905097
75MP0005058_abnormal_lysosome_morphology1.11605176
76MP0010234_abnormal_vibrissa_follicle1.10335710
77MP0004510_myositis1.10292224
78MP0000358_abnormal_cell_content/1.09690083
79MP0003121_genomic_imprinting1.09480757
80MP0003567_abnormal_fetal_cardiomyocyte1.09239334
81MP0002102_abnormal_ear_morphology1.08857778
82MP0003634_abnormal_glial_cell1.08569623
83MP0003172_abnormal_lysosome_physiology1.08441193
84MP0002796_impaired_skin_barrier1.08194846
85MP0003942_abnormal_urinary_system1.07344168
86MP0005369_muscle_phenotype1.07312146
87MP0002127_abnormal_cardiovascular_syste1.03493838
88MP0002736_abnormal_nociception_after1.02992651
89MP0001697_abnormal_embryo_size1.01276180
90MP0000049_abnormal_middle_ear1.01260340
91MP0009672_abnormal_birth_weight1.01232142
92MP0001544_abnormal_cardiovascular_syste0.99454164
93MP0005385_cardiovascular_system_phenoty0.99454164
94MP0001727_abnormal_embryo_implantation0.98150337
95MP0002080_prenatal_lethality0.97770033
96MP0005621_abnormal_cell_physiology0.96943680
97MP0000538_abnormal_urinary_bladder0.95117819
98MP0010094_abnormal_chromosome_stability0.94911492
99MP0010630_abnormal_cardiac_muscle0.94745781
100MP0000858_altered_metastatic_potential0.94739264
101MP0003075_altered_response_to0.94347658
102MP0005620_abnormal_muscle_contractility0.93937575
103MP0001346_abnormal_lacrimal_gland0.93568536
104MP0003385_abnormal_body_wall0.93467813
105MP0008438_abnormal_cutaneous_collagen0.91355047
106MP0004215_abnormal_myocardial_fiber0.91013248
107MP0002249_abnormal_larynx_morphology0.90198177
108MP0005384_cellular_phenotype0.89941162
109MP0003861_abnormal_nervous_system0.89696064
110MP0002332_abnormal_exercise_endurance0.89295679
111MP0004197_abnormal_fetal_growth/weight/0.89117708
112MP0000955_abnormal_spinal_cord0.87565734
113MP0002909_abnormal_adrenal_gland0.86609525
114MP0002064_seizures0.86222292
115MP0005623_abnormal_meninges_morphology0.86210262
116MP0003718_maternal_effect0.85910115
117MP0002085_abnormal_embryonic_tissue0.85565528
118MP0005380_embryogenesis_phenotype0.85347607
119MP0001672_abnormal_embryogenesis/_devel0.85347607
120MP0000604_amyloidosis0.85297659
121MP0009333_abnormal_splenocyte_physiolog0.85077933
122MP0000490_abnormal_crypts_of0.84875473
123MP0001915_intracranial_hemorrhage0.84138375
124MP0009053_abnormal_anal_canal0.82396589
125MP0002152_abnormal_brain_morphology0.81637915
126MP0004811_abnormal_neuron_physiology0.81399437
127MP0003786_premature_aging0.81240349
128MP0003315_abnormal_perineum_morphology0.80080151
129MP0004270_analgesia0.79523251
130MP0002972_abnormal_cardiac_muscle0.78995967
131MP0008058_abnormal_DNA_repair0.78740514
132MP0004782_abnormal_surfactant_physiolog0.78702911
133MP0008789_abnormal_olfactory_epithelium0.78487651
134MP0000467_abnormal_esophagus_morphology0.77462503
135MP0003984_embryonic_growth_retardation0.77446329
136MP0005386_behavior/neurological_phenoty0.76735154
137MP0004924_abnormal_behavior0.76735154
138MP0002088_abnormal_embryonic_growth/wei0.76508644
139MP0005266_abnormal_metabolism0.75762390
140MP0000678_abnormal_parathyroid_gland0.75033253
141MP0005423_abnormal_somatic_nervous0.73509164
142MP0002086_abnormal_extraembryonic_tissu0.72839803
143MP0001661_extended_life_span0.69605345
144MP0008874_decreased_physiological_sensi0.67674400
145MP0002970_abnormal_white_adipose0.66836909
146MP0003303_peritoneal_inflammation0.64174940

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolysis (HP:0004366)4.18478769
2Increased serum pyruvate (HP:0003542)4.18478769
3Cerebral hypomyelination (HP:0006808)4.12559640
4Upper limb amyotrophy (HP:0009129)3.83799536
5Distal upper limb amyotrophy (HP:0007149)3.83799536
6Hyperacusis (HP:0010780)3.80239864
7Distal lower limb amyotrophy (HP:0008944)3.36776539
8Insomnia (HP:0100785)3.34628840
9Centrally nucleated skeletal muscle fibers (HP:0003687)3.34202619
10Achilles tendon contracture (HP:0001771)3.29862531
11Ragged-red muscle fibers (HP:0003200)3.17840759
12Unsteady gait (HP:0002317)3.04606756
13Shoulder girdle muscle weakness (HP:0003547)3.04002549
14Abnormality of the aortic arch (HP:0012303)3.00544746
15Abnormality of the labia minora (HP:0012880)2.95664386
16Delusions (HP:0000746)2.91341544
17Distal lower limb muscle weakness (HP:0009053)2.90689065
18Mesangial abnormality (HP:0001966)2.86488601
19Abnormality of the Achilles tendon (HP:0005109)2.83043865
20Progressive muscle weakness (HP:0003323)2.81627177
21Increased connective tissue (HP:0009025)2.76876341
22Lower limb amyotrophy (HP:0007210)2.76174487
23Abnormality of the lower motor neuron (HP:0002366)2.64374590
24Long palpebral fissure (HP:0000637)2.63907174
25Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.61943614
26Abnormality of alanine metabolism (HP:0010916)2.61943614
27Hyperalaninemia (HP:0003348)2.61943614
28Muscle fiber splitting (HP:0003555)2.60506267
29Stridor (HP:0010307)2.60042968
30Atrophy/Degeneration involving motor neurons (HP:0007373)2.58942113
31Microvesicular hepatic steatosis (HP:0001414)2.57791670
32Upper limb muscle weakness (HP:0003484)2.55084166
33Oligomenorrhea (HP:0000876)2.54215492
34Polyphagia (HP:0002591)2.52357317
35Amyotrophic lateral sclerosis (HP:0007354)2.47678834
36Failure to thrive in infancy (HP:0001531)2.46838636
37Athetosis (HP:0002305)2.44589119
38Ulnar bowing (HP:0003031)2.39789054
39Emotional lability (HP:0000712)2.38859914
40Hyperglycinemia (HP:0002154)2.38255551
41Vertebral compression fractures (HP:0002953)2.37697051
42Pelvic girdle muscle weakness (HP:0003749)2.37118337
43Cholelithiasis (HP:0001081)2.35234740
44Reticulocytosis (HP:0001923)2.32929624
45Exercise-induced myalgia (HP:0003738)2.31951847
46Poor suck (HP:0002033)2.28891736
47Hyperglycinuria (HP:0003108)2.26853864
48Spinal rigidity (HP:0003306)2.26484896
49Abnormality of the anterior horn cell (HP:0006802)2.25215073
50Degeneration of anterior horn cells (HP:0002398)2.25215073
51Multiple enchondromatosis (HP:0005701)2.25181664
52Broad distal phalanx of finger (HP:0009836)2.25120477
53Rhabdomyolysis (HP:0003201)2.22721583
54CNS hypomyelination (HP:0003429)2.21903462
55Birth length less than 3rd percentile (HP:0003561)2.21083624
56Visual hallucinations (HP:0002367)2.21006903
57Breast hypoplasia (HP:0003187)2.18211591
58Personality changes (HP:0000751)2.17525916
59Peripheral hypomyelination (HP:0007182)2.17046574
60Premature rupture of membranes (HP:0001788)2.16987988
61Exercise-induced muscle cramps (HP:0003710)2.16533860
62Asymmetric septal hypertrophy (HP:0001670)2.15655119
63Microretrognathia (HP:0000308)2.14868681
64Rimmed vacuoles (HP:0003805)2.13507718
65Cortical dysplasia (HP:0002539)2.13231594
66Ankle clonus (HP:0011448)2.13213847
67Hepatocellular necrosis (HP:0001404)2.12591310
68Abnormality of the gallbladder (HP:0005264)2.12142209
69Sudden death (HP:0001699)2.11027961
70Abnormal mitochondria in muscle tissue (HP:0008316)2.10978407
71Abnormality of the hip-girdle musculature (HP:0001445)2.10171131
72Abnormality of the musculature of the pelvis (HP:0001469)2.10171131
73Large eyes (HP:0001090)2.09106147
74Pointed chin (HP:0000307)2.08464980
75Postnatal microcephaly (HP:0005484)2.07405143
76Overriding aorta (HP:0002623)2.07316503
77Myopathic facies (HP:0002058)2.05866305
78Wrist flexion contracture (HP:0001239)2.05366117
79Difficulty climbing stairs (HP:0003551)2.05253586
80Patellar aplasia (HP:0006443)2.04705426
81Neuronal loss in central nervous system (HP:0002529)2.04409696
82Diaphragmatic weakness (HP:0009113)2.04155075
83Abnormality of the motor neurons (HP:0002450)2.03475707
84Abnormal neuron morphology (HP:0012757)2.03475707
85Trismus (HP:0000211)2.03332625
86Cerebral inclusion bodies (HP:0100314)2.02733393
87Supranuclear gaze palsy (HP:0000605)2.02589384
88Patent foramen ovale (HP:0001655)2.02190924
89Abnormality of serine family amino acid metabolism (HP:0010894)2.01994407
90Abnormality of glycine metabolism (HP:0010895)2.01994407
91Hepatic necrosis (HP:0002605)2.01567661
92Aplasia/Hypoplasia of the patella (HP:0006498)2.01273151
93Abnormality of serum amino acid levels (HP:0003112)1.99610230
94Disproportionate tall stature (HP:0001519)1.99527434
95Selective tooth agenesis (HP:0001592)1.98187363
96Muscle fibrillation (HP:0010546)1.97706833
97Apathy (HP:0000741)1.97612115
98Abnormal gallbladder morphology (HP:0012437)1.96738068
99Back pain (HP:0003418)1.96607848
100Neurofibrillary tangles (HP:0002185)1.96396577
101CNS demyelination (HP:0007305)1.96298705
102Ependymoma (HP:0002888)1.95877702
103Global brain atrophy (HP:0002283)1.94737325
104Premature skin wrinkling (HP:0100678)1.94643021
105Abnormality of pain sensation (HP:0010832)1.94345009
106Impaired pain sensation (HP:0007328)1.94345009
107Upper motor neuron abnormality (HP:0002127)1.94057198
108Distal sensory impairment (HP:0002936)1.92848004
109Increased serum lactate (HP:0002151)1.92767349
110Acute necrotizing encephalopathy (HP:0006965)1.92036475
111Hammertoe (HP:0001765)1.91411755
112Increased CSF lactate (HP:0002490)1.91034736
113Myokymia (HP:0002411)1.88941160
114Myoglobinuria (HP:0002913)1.88373124
115Acute encephalopathy (HP:0006846)1.88215165
116Tongue fasciculations (HP:0001308)1.87725023
117Elfin facies (HP:0004428)1.87057121
118Abnormal large intestine physiology (HP:0012700)1.86485089
119Foot dorsiflexor weakness (HP:0009027)1.85877415
120Diminished motivation (HP:0000745)1.85798920
121Gout (HP:0001997)1.85219873
122Generalized amyotrophy (HP:0003700)1.85179360
123Bowel incontinence (HP:0002607)1.85044402
124Obstructive sleep apnea (HP:0002870)1.85032282
125Lactic acidosis (HP:0003128)1.84047223
126Turricephaly (HP:0000262)1.83210356
127Abnormality of skeletal muscle fiber size (HP:0012084)1.83009431
128Axonal loss (HP:0003447)1.82450969
129Bicornuate uterus (HP:0000813)1.82417336
130Adducted thumb (HP:0001181)1.81617709
131Truncus arteriosus (HP:0001660)1.81391924
132Short palpebral fissure (HP:0012745)1.80447334
133Lissencephaly (HP:0001339)1.78840274
134Pheochromocytoma (HP:0002666)1.78073381
135Rough bone trabeculation (HP:0100670)1.77402106
136Increased variability in muscle fiber diameter (HP:0003557)1.75883904
137Abnormal gallbladder physiology (HP:0012438)1.75826035
138Cholecystitis (HP:0001082)1.75826035
139Abnormality of fatty-acid metabolism (HP:0004359)1.75771836
140Megaloblastic anemia (HP:0001889)1.73033700
141Neoplasm of the adrenal gland (HP:0100631)1.72586466
142Mildly elevated creatine phosphokinase (HP:0008180)1.72563035
143Limb-girdle muscle atrophy (HP:0003797)1.72165488
144Myotonia (HP:0002486)1.72002784
145Angiofibromas (HP:0010615)1.71327888
146Adenoma sebaceum (HP:0009720)1.71327888
147Abnormality of the calcaneus (HP:0008364)1.71302257
148Calcaneovalgus deformity (HP:0001848)1.71272342
149Hyperparathyroidism (HP:0000843)1.71233494
150Progressive external ophthalmoplegia (HP:0000590)1.71193392
151Abnormal eating behavior (HP:0100738)1.70866567
152Abnormality of the umbilical cord (HP:0010881)1.70844437
153Spastic diplegia (HP:0001264)1.70740854
154Annular pancreas (HP:0001734)1.70579487
155Oral leukoplakia (HP:0002745)1.70450693
156Hand muscle atrophy (HP:0009130)1.69790442
157Mitochondrial inheritance (HP:0001427)1.68424850
158Abnormality of the foot musculature (HP:0001436)1.67959946
159Renal duplication (HP:0000075)1.67447327
160Deformed tarsal bones (HP:0008119)1.67343537
161Death in infancy (HP:0001522)1.67018531
162Secondary amenorrhea (HP:0000869)1.66283735
163Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.65875547
164Patellar dislocation (HP:0002999)1.65664741
165Hyperthyroidism (HP:0000836)1.65385646
166Muscle stiffness (HP:0003552)1.64766653
167Glossoptosis (HP:0000162)1.64236865
168Abnormality of the tricuspid valve (HP:0001702)1.62343909
169Deep palmar crease (HP:0006191)1.60942867
170Depression (HP:0000716)1.60932958
171Broad face (HP:0000283)1.60867370
172High anterior hairline (HP:0009890)1.60093748
173Shallow orbits (HP:0000586)1.58501713
174Muscle fiber inclusion bodies (HP:0100299)1.58444379
175Protrusio acetabuli (HP:0003179)1.58201139
176Termporal pattern (HP:0011008)1.58002661
177Insidious onset (HP:0003587)1.58002661
178Hypertensive crisis (HP:0100735)1.57193320
179Unilateral renal agenesis (HP:0000122)1.56509623
180Abnormality of reticulocytes (HP:0004312)1.56447312
181Type 1 muscle fiber predominance (HP:0003803)1.55929179

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.60246157
2TIE13.58024850
3SMG13.41919474
4NEK13.21514850
5NME23.00386261
6TSSK62.90161757
7IRAK32.79981223
8PRPF4B2.52533594
9BCKDK2.37479903
10MARK12.26391609
11PDK42.13483169
12PDK32.13483169
13TESK21.99597900
14STK161.96642107
15CDK121.91089169
16TRIB31.89504639
17LATS21.82339214
18LIMK11.78044995
19TESK11.73935983
20DYRK21.71576343
21MAP3K91.69674433
22ARAF1.67632764
23LMTK21.66952975
24VRK21.65341677
25BRAF1.64734015
26EIF2AK11.62093469
27CCNB11.60717264
28PRKD31.56511311
29SIK11.50292607
30SIK31.49806828
31MINK11.46096086
32KSR11.44795687
33WEE11.44228229
34SRPK11.32718771
35BMX1.32579337
36BRSK11.25728467
37MAP3K101.24637778
38PHKG21.23582829
39PHKG11.23582829
40PAK61.23539183
41NME11.23191380
42MAP3K111.23176002
43RIPK11.23120503
44ACVR1B1.16992488
45NTRK21.12595667
46CDK181.10717924
47AURKA1.07710564
48CDK191.06607711
49EPHA21.06559285
50PAK41.03938656
51PDK21.03768251
52MAP3K81.03446754
53CDK151.01768291
54CDK141.01587528
55PLK31.01267829
56NTRK11.00331076
57DYRK30.99030267
58CDK70.98505022
59NEK20.93960083
60UHMK10.93881984
61ICK0.93752366
62DAPK10.92565356
63CDK11A0.92390771
64PLK10.91880979
65PIM20.91419124
66MAP3K120.89664814
67DDR20.88548011
68AKT30.88519384
69DAPK30.88477755
70STK38L0.87430135
71MTOR0.86349629
72PRKCI0.85587609
73MAP2K30.85236897
74PAK10.85191882
75SIK20.83940825
76PDGFRA0.83675233
77PRKCG0.83596242
78PTK20.82239571
79EPHB20.81965583
80TTK0.79382969
81BCR0.79035543
82PASK0.77544202
83CAMK1D0.76090946
84ILK0.75633568
85MAP2K10.74177316
86DAPK20.72672783
87KSR20.72333128
88PLK20.70864851
89PAK30.69189302
90CDK40.67758571
91ERN10.67635071
92FGFR40.67457843
93SCYL20.67331558
94PKN20.67171647
95TTN0.66977793
96PBK0.64319524
97PRKD20.64116730
98CLK10.63910545
99MARK20.63076282
100MOS0.61637459
101TGFBR10.61619117
102PTK2B0.61424953
103RPS6KA20.61216329
104MAPK110.59974975
105FER0.58842892
106PNCK0.58657555
107MAPK130.57477826
108ABL20.57078818
109MAP2K20.56295812
110CHEK10.56147841
111CDK80.55785922
112WNK30.53579182
113PDPK10.53551762
114IRAK20.52495632
115MAP3K60.50852159
116RAF10.49997776
117* AKT20.49613713
118CSNK1G30.49569468
119MYLK0.49526282
120TYRO30.49479272
121MET0.48704029
122CDC70.48271835
123KDR0.48057371
124MAP3K10.47347172
125DYRK1B0.46592289
126CAMKK10.46037825
127CDK90.45585991
128FGFR10.45058785
129LRRK20.44686669
130CDK20.43919889
131ALK0.43630988
132OBSCN0.43581324
133CDK50.43272194
134MAP3K40.42997040
135MST1R0.42971494
136EPHB10.41618590
137CAMK2G0.41351940
138PRKG20.40327790
139MAP2K40.40188105
140PAK20.40044553
141PRKCZ0.39528399
142CSNK1A1L0.39365213
143ERBB30.39299975
144PLK40.39252146
145TAOK20.38618312
146ROCK10.38036574
147EEF2K0.36275656
148EPHA40.36031899
149TAOK10.35788579
150CHEK20.32460177
151MAPK90.31731764
152GRK50.30750426
153BMPR1B0.30322682

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.38940260
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.92207328
3Proteasome_Homo sapiens_hsa030503.46862590
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.64220221
5Carbon metabolism_Homo sapiens_hsa012002.47552243
6Biosynthesis of amino acids_Homo sapiens_hsa012302.47164324
7Vitamin B6 metabolism_Homo sapiens_hsa007502.26215798
8RNA polymerase_Homo sapiens_hsa030202.21013130
9Fructose and mannose metabolism_Homo sapiens_hsa000512.11634529
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.00514767
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.98508664
12Spliceosome_Homo sapiens_hsa030401.93133020
13RNA transport_Homo sapiens_hsa030131.86116316
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.83597952
15Oxidative phosphorylation_Homo sapiens_hsa001901.76645002
16Synaptic vesicle cycle_Homo sapiens_hsa047211.74865613
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.74782565
18Parkinsons disease_Homo sapiens_hsa050121.73688066
19Cysteine and methionine metabolism_Homo sapiens_hsa002701.68663891
20Pyruvate metabolism_Homo sapiens_hsa006201.68234557
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.63691713
22Base excision repair_Homo sapiens_hsa034101.55350810
23DNA replication_Homo sapiens_hsa030301.54225231
24Cardiac muscle contraction_Homo sapiens_hsa042601.52810192
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.45738848
26Huntingtons disease_Homo sapiens_hsa050161.37121255
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.34036534
28Propanoate metabolism_Homo sapiens_hsa006401.33727732
29Other glycan degradation_Homo sapiens_hsa005111.33299302
30Pyrimidine metabolism_Homo sapiens_hsa002401.30665379
31Pentose phosphate pathway_Homo sapiens_hsa000301.26737719
32Oocyte meiosis_Homo sapiens_hsa041141.23380663
33Chronic myeloid leukemia_Homo sapiens_hsa052201.21585892
34Regulation of autophagy_Homo sapiens_hsa041401.18559004
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17481527
36Galactose metabolism_Homo sapiens_hsa000521.16761846
37Cell cycle_Homo sapiens_hsa041101.16619597
38Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.15913110
39Mismatch repair_Homo sapiens_hsa034301.10910626
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04934220
41Collecting duct acid secretion_Homo sapiens_hsa049661.04749948
42Selenocompound metabolism_Homo sapiens_hsa004501.04314912
43Vibrio cholerae infection_Homo sapiens_hsa051101.00558421
44VEGF signaling pathway_Homo sapiens_hsa043700.98000765
45One carbon pool by folate_Homo sapiens_hsa006700.97544522
46Shigellosis_Homo sapiens_hsa051310.95214881
47Acute myeloid leukemia_Homo sapiens_hsa052210.94956636
48Purine metabolism_Homo sapiens_hsa002300.93393920
49Butanoate metabolism_Homo sapiens_hsa006500.91601535
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90988485
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90788948
52Arginine biosynthesis_Homo sapiens_hsa002200.90745680
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.90534584
54Alzheimers disease_Homo sapiens_hsa050100.87926993
55Fatty acid metabolism_Homo sapiens_hsa012120.86291033
56Notch signaling pathway_Homo sapiens_hsa043300.84957122
57mRNA surveillance pathway_Homo sapiens_hsa030150.84646342
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.83699200
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83288597
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80583948
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79831396
62HIF-1 signaling pathway_Homo sapiens_hsa040660.79479566
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79205536
64N-Glycan biosynthesis_Homo sapiens_hsa005100.76814706
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.75955209
66Salmonella infection_Homo sapiens_hsa051320.75282749
67Hippo signaling pathway_Homo sapiens_hsa043900.75136292
68Glycerophospholipid metabolism_Homo sapiens_hsa005640.74045610
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72814352
70Gap junction_Homo sapiens_hsa045400.71716566
71Glioma_Homo sapiens_hsa052140.71525968
72Steroid biosynthesis_Homo sapiens_hsa001000.71455839
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71135880
74Endocytosis_Homo sapiens_hsa041440.70524064
75Non-small cell lung cancer_Homo sapiens_hsa052230.69521147
76Pancreatic cancer_Homo sapiens_hsa052120.68292190
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67768934
78Hedgehog signaling pathway_Homo sapiens_hsa043400.66288993
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66171613
80Dilated cardiomyopathy_Homo sapiens_hsa054140.65806697
81ErbB signaling pathway_Homo sapiens_hsa040120.63369197
82Nucleotide excision repair_Homo sapiens_hsa034200.63308972
83Thyroid cancer_Homo sapiens_hsa052160.62164780
84Insulin signaling pathway_Homo sapiens_hsa049100.61679896
85Apoptosis_Homo sapiens_hsa042100.61646247
86Basal cell carcinoma_Homo sapiens_hsa052170.61180101
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60920199
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60236294
89Endometrial cancer_Homo sapiens_hsa052130.57980351
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56160290
91Fatty acid degradation_Homo sapiens_hsa000710.55720627
92Sulfur relay system_Homo sapiens_hsa041220.55572782
93Viral carcinogenesis_Homo sapiens_hsa052030.53109759
94Glucagon signaling pathway_Homo sapiens_hsa049220.52750738
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52696561
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52377975
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51656377
98AMPK signaling pathway_Homo sapiens_hsa041520.51400248
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.50646180
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50591613
101Tight junction_Homo sapiens_hsa045300.49590330
102Nicotine addiction_Homo sapiens_hsa050330.49472563
103Folate biosynthesis_Homo sapiens_hsa007900.49148005
104Bladder cancer_Homo sapiens_hsa052190.48491260
105Arginine and proline metabolism_Homo sapiens_hsa003300.47306393
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45939253
107Epstein-Barr virus infection_Homo sapiens_hsa051690.44441057
108Lysine degradation_Homo sapiens_hsa003100.41856801
109Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41699137
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40988889
111Metabolic pathways_Homo sapiens_hsa011000.40809209
112mTOR signaling pathway_Homo sapiens_hsa041500.39467974
113Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39087505
114Lysosome_Homo sapiens_hsa041420.38332243
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36791896
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.36333781
117Colorectal cancer_Homo sapiens_hsa052100.35506015
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.35470591
119p53 signaling pathway_Homo sapiens_hsa041150.35293757
120GABAergic synapse_Homo sapiens_hsa047270.35146282
121Basal transcription factors_Homo sapiens_hsa030220.34258992
122Estrogen signaling pathway_Homo sapiens_hsa049150.34176705
123Hepatitis B_Homo sapiens_hsa051610.34157452
124Axon guidance_Homo sapiens_hsa043600.32689159
125HTLV-I infection_Homo sapiens_hsa051660.31682520
126Renal cell carcinoma_Homo sapiens_hsa052110.31495023
127Olfactory transduction_Homo sapiens_hsa047400.30053719
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29969019
129Prion diseases_Homo sapiens_hsa050200.29504888
130Fatty acid elongation_Homo sapiens_hsa000620.28431417
131Melanogenesis_Homo sapiens_hsa049160.27315536
132Ribosome_Homo sapiens_hsa030100.26665894
133Fat digestion and absorption_Homo sapiens_hsa049750.25545269
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25027880
135PPAR signaling pathway_Homo sapiens_hsa033200.24727516
136Phenylalanine metabolism_Homo sapiens_hsa003600.24032790

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