SH2B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SH2-domain containing mediators family. The encoded protein mediates activation of various kinases and may function in cytokine and growth factor receptor signaling and cellular transformation. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mannose metabolic process (GO:0006013)5.05949881
2negative regulation of cell size (GO:0045792)4.38748132
3positive regulation of histone deacetylation (GO:0031065)4.09625201
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.01559706
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.01559706
6lysine metabolic process (GO:0006553)3.99801536
7lysine catabolic process (GO:0006554)3.99801536
8regulation of fatty acid beta-oxidation (GO:0031998)3.82770293
9regulation of cholesterol homeostasis (GO:2000188)3.73503894
102-oxoglutarate metabolic process (GO:0006103)3.71091990
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.69763079
12negative regulation of cell killing (GO:0031342)3.69763079
13regulation of ARF protein signal transduction (GO:0032012)3.68444613
14maternal placenta development (GO:0001893)3.66142952
15regulation of gamma-delta T cell differentiation (GO:0045586)3.61762931
16negative regulation of erythrocyte differentiation (GO:0045647)3.52270689
17alpha-linolenic acid metabolic process (GO:0036109)3.44984216
18carnitine shuttle (GO:0006853)3.42479198
19peptidyl-lysine dimethylation (GO:0018027)3.42216025
20positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.39090118
21pre-miRNA processing (GO:0031054)3.36503398
22tricarboxylic acid metabolic process (GO:0072350)3.35975021
23antigen processing and presentation of endogenous antigen (GO:0019883)3.28931719
24negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.28876918
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.23122867
26oxaloacetate metabolic process (GO:0006107)3.18148212
27positive thymic T cell selection (GO:0045059)3.15593859
28positive regulation of fatty acid beta-oxidation (GO:0032000)3.10045789
29regulation of fatty acid oxidation (GO:0046320)3.09820781
30positive regulation of synapse maturation (GO:0090129)3.08997489
31positive regulation of triglyceride biosynthetic process (GO:0010867)3.07917853
32negative regulation of potassium ion transmembrane transport (GO:1901380)3.06602556
33fatty acid transmembrane transport (GO:1902001)3.04873975
34negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.03169574
35regulation of extracellular matrix disassembly (GO:0010715)3.03079084
36regulation of translational fidelity (GO:0006450)2.99992369
37intracellular estrogen receptor signaling pathway (GO:0030520)2.98219892
38dicarboxylic acid biosynthetic process (GO:0043650)2.97684295
39positive regulation of protein deacetylation (GO:0090312)2.97492458
40positive regulation of CREB transcription factor activity (GO:0032793)2.96734655
41semaphorin-plexin signaling pathway (GO:0071526)2.93118757
42synaptic vesicle docking involved in exocytosis (GO:0016081)2.93004005
43T cell selection (GO:0045058)2.92559468
44cell-cell junction maintenance (GO:0045217)2.89222147
454-hydroxyproline metabolic process (GO:0019471)2.87433758
46positive regulation of Rap GTPase activity (GO:0032854)2.86955756
47valine metabolic process (GO:0006573)2.86846199
48regulation of gamma-delta T cell activation (GO:0046643)2.86792698
49negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.85823047
50aspartate family amino acid catabolic process (GO:0009068)2.85787267
51sodium ion export (GO:0071436)2.85399235
52sarcomere organization (GO:0045214)2.83860289
53pentose-phosphate shunt (GO:0006098)2.83446705
54antigen processing and presentation via MHC class Ib (GO:0002475)2.83257206
55negative regulation of nucleotide catabolic process (GO:0030812)2.83236703
56adherens junction assembly (GO:0034333)2.82010048
57mitotic G1 DNA damage checkpoint (GO:0031571)2.81304236
58negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.80296470
59activation of JUN kinase activity (GO:0007257)2.80206686
60signal complex assembly (GO:0007172)2.79996382
61plasma membrane repair (GO:0001778)2.79434293
62regulation of NFAT protein import into nucleus (GO:0051532)2.78836200
63peptidyl-tyrosine autophosphorylation (GO:0038083)2.78728431
64focal adhesion assembly (GO:0048041)2.77212016
65cell-substrate adherens junction assembly (GO:0007045)2.77212016
66histone H4 deacetylation (GO:0070933)2.74984954
67negative regulation of heart growth (GO:0061117)2.74719920
68negative regulation of cardiac muscle tissue growth (GO:0055022)2.74719920
69positive regulation of gamma-delta T cell activation (GO:0046645)2.74448967
70response to muramyl dipeptide (GO:0032495)2.72279129
71regulation of ARF GTPase activity (GO:0032312)2.69060616
72glucocorticoid receptor signaling pathway (GO:0042921)2.68238371
73cytoskeletal anchoring at plasma membrane (GO:0007016)2.68169131
74activation of MAPKKK activity (GO:0000185)2.68102249
75regulation of synapse maturation (GO:0090128)2.67139111
76apoptotic process involved in morphogenesis (GO:0060561)2.65966009
77cardiac muscle contraction (GO:0060048)2.64086396
78thymic T cell selection (GO:0045061)2.64034790
79histone H3 deacetylation (GO:0070932)2.63651139
80nucleosome disassembly (GO:0006337)2.62098074
81protein-DNA complex disassembly (GO:0032986)2.62098074
82positive T cell selection (GO:0043368)2.61311991
83negative regulation of sterol transport (GO:0032372)2.61000820
84negative regulation of cholesterol transport (GO:0032375)2.61000820
85negative thymic T cell selection (GO:0045060)2.59424288
86carnitine transmembrane transport (GO:1902603)2.59056160
87germinal center formation (GO:0002467)2.58832060
88positive regulation of protein dephosphorylation (GO:0035307)2.58078686
89glyoxylate metabolic process (GO:0046487)2.57567259
90cardiac myofibril assembly (GO:0055003)2.56938373
91fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.54608973
92tricarboxylic acid cycle (GO:0006099)2.53574423
93positive regulation of glycogen biosynthetic process (GO:0045725)2.52750720
94negative regulation of lipid transport (GO:0032369)2.52641115
95detection of bacterium (GO:0016045)2.51151845
96negative regulation of myotube differentiation (GO:0010832)2.50774195
97activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.49898145
98amino-acid betaine transport (GO:0015838)2.49168694
99carnitine transport (GO:0015879)2.49168694
100positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.47552816
101positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.46586573
102positive regulation of nuclease activity (GO:0032075)2.45563645
103modulation by virus of host process (GO:0019054)2.44510721
104positive regulation of triglyceride metabolic process (GO:0090208)2.44335764
105macrophage activation involved in immune response (GO:0002281)2.43661913
106activation of Rac GTPase activity (GO:0032863)2.41847251
107negative regulation of purine nucleotide catabolic process (GO:0033122)2.41770464
108endothelial cell chemotaxis (GO:0035767)2.41520614
109fatty acid homeostasis (GO:0055089)2.41506047
110mitotic G1/S transition checkpoint (GO:0044819)2.37869341
111negative T cell selection (GO:0043383)2.37450954
112nucleotide salvage (GO:0043173)2.37012228
113sulfur amino acid catabolic process (GO:0000098)2.36956333
114positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.36684390
115cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.36588039
116positive regulation of gene expression, epigenetic (GO:0045815)2.36576512
117NADH metabolic process (GO:0006734)2.36120053
118kynurenine metabolic process (GO:0070189)2.35966060
119NADPH regeneration (GO:0006740)2.35711879
120erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.35606658
121L-phenylalanine metabolic process (GO:0006558)2.35606658
122regulation of histone H3-K27 methylation (GO:0061085)2.35063152
123cellular response to interleukin-4 (GO:0071353)2.34675566
124regulation of hydrogen peroxide metabolic process (GO:0010310)2.34557100
125positive regulation of myotube differentiation (GO:0010831)2.33989431
126regulation of triglyceride biosynthetic process (GO:0010866)2.33985867
127positive regulation of fatty acid oxidation (GO:0046321)2.33602858
128response to laminar fluid shear stress (GO:0034616)2.32341997
129positive regulation of lamellipodium assembly (GO:0010592)2.31270102
130detection of other organism (GO:0098543)2.30968021
131cell communication by electrical coupling (GO:0010644)2.30850281
132negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.30709179
133leukocyte aggregation (GO:0070486)2.29930275
134regulation of translational termination (GO:0006449)2.28706810
135positive regulation of RNA splicing (GO:0033120)2.27588709
136natural killer cell differentiation (GO:0001779)2.27555069
137histone H4-K16 acetylation (GO:0043984)2.26960744
138heterochromatin organization (GO:0070828)2.26809305
139epithelial cell differentiation involved in prostate gland development (GO:0060742)2.26378028
140negative regulation of RNA splicing (GO:0033119)2.26219444
141modulation by symbiont of host cellular process (GO:0044068)2.25881047
142cell-substrate junction assembly (GO:0007044)2.25604475
143B cell receptor signaling pathway (GO:0050853)2.25370321
144phosphatidylglycerol biosynthetic process (GO:0006655)2.25209033
145regulation of Rap GTPase activity (GO:0032317)2.25025889
146diacylglycerol metabolic process (GO:0046339)2.24809424
147negative regulation of toll-like receptor signaling pathway (GO:0034122)2.23103720
148cell junction maintenance (GO:0034331)2.22381564
149activation of protein kinase A activity (GO:0034199)2.21468454
150negative regulation of leukocyte mediated immunity (GO:0002704)2.19699109
151entrainment of circadian clock by photoperiod (GO:0043153)2.18944338
152positive regulation of Cdc42 GTPase activity (GO:0043089)2.17744333
153synaptic vesicle exocytosis (GO:0016079)2.17708239
154regulation of monocyte differentiation (GO:0045655)2.17641457
155regulation of type I interferon-mediated signaling pathway (GO:0060338)2.17496747
156Peyers patch development (GO:0048541)2.17083224
157mucosal-associated lymphoid tissue development (GO:0048537)2.17083224
158negative regulation of granulocyte differentiation (GO:0030853)2.16417946
159negative regulation of innate immune response (GO:0045824)2.16023243
160positive regulation of protein kinase C signaling (GO:0090037)2.15963985
161negative regulation of lymphocyte mediated immunity (GO:0002707)2.15624628
162cell volume homeostasis (GO:0006884)2.14926934
163cell migration in hindbrain (GO:0021535)2.13701864
164retrograde transport, endosome to Golgi (GO:0042147)2.13012085
165histone H4-K12 acetylation (GO:0043983)2.12887803
166modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.12218995
167positive regulation by organism of defense response of other organism involved in symbiotic interact2.12218995
168modulation by symbiont of host immune response (GO:0052553)2.12218995
169positive regulation by symbiont of host defense response (GO:0052509)2.12218995
170modulation by symbiont of host defense response (GO:0052031)2.12218995
171modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.12218995
172atrioventricular valve morphogenesis (GO:0003181)2.11720161
173regulation of leukocyte degranulation (GO:0043300)2.11160365
174regulation of extracellular matrix organization (GO:1903053)2.10987791
175negative regulation of Ras protein signal transduction (GO:0046580)2.10946504
176G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.10529210

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.96111625
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.01474009
3VDR_21846776_ChIP-Seq_THP-1_Human2.96621561
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.91268161
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.83733076
6KDM2B_26808549_Chip-Seq_DND41_Human2.65912265
7LXR_22292898_ChIP-Seq_THP-1_Human2.60109349
8* TCF7_22412390_ChIP-Seq_EML_Mouse2.58740766
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.58472651
10KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.40224139
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.39062111
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.30365216
13KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.29054978
14TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.25893548
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.20252146
16RXR_22158963_ChIP-Seq_LIVER_Mouse2.16422646
17ZFP281_18757296_ChIP-ChIP_E14_Mouse2.09829582
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.07294931
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.94306192
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.92807752
21ZNF263_19887448_ChIP-Seq_K562_Human1.91240075
22* MAF_26560356_Chip-Seq_TH1_Human1.89300430
23CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.88694125
24UTX_26944678_Chip-Seq_JUKART_Human1.86410574
25ERG_21242973_ChIP-ChIP_JURKAT_Human1.86165307
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83037255
27DROSHA_22980978_ChIP-Seq_HELA_Human1.79601539
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.79175663
29FOXM1_23109430_ChIP-Seq_U2OS_Human1.78049082
30KDM2B_26808549_Chip-Seq_JURKAT_Human1.74548954
31RACK7_27058665_Chip-Seq_MCF-7_Human1.72867727
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.68893376
33KDM2B_26808549_Chip-Seq_K562_Human1.64464991
34* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.64218867
35CTCF_27219007_Chip-Seq_Bcells_Human1.63030978
36SCL_19346495_ChIP-Seq_HPC-7_Human1.59210448
37P68_20966046_ChIP-Seq_HELA_Human1.58728255
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58577936
39EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.56542728
40ZFP281_27345836_Chip-Seq_ESCs_Mouse1.55572355
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.54940716
42ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.53135432
43* ELF1_20517297_ChIP-Seq_JURKAT_Human1.50803525
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.50747146
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.49448990
46CIITA_25753668_ChIP-Seq_RAJI_Human1.48910225
47LXR_22158963_ChIP-Seq_LIVER_Mouse1.47287287
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46900980
49SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.46383498
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44333793
51CLOCK_20551151_ChIP-Seq_293T_Human1.43484836
52CREB1_26743006_Chip-Seq_LNCaP_Human1.43429234
53MAF_26560356_Chip-Seq_TH2_Human1.42434863
54VDR_24763502_ChIP-Seq_THP-1_Human1.41366737
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41041959
56TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40817445
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.39772631
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36225645
59P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35908688
60CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.34011246
61DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.33251923
62SA1_27219007_Chip-Seq_ERYTHROID_Human1.32572687
63CTCF_21964334_ChIP-Seq_BJAB-B_Human1.30830105
64NCOR1_26117541_ChIP-Seq_K562_Human1.28920615
65BCL6_27268052_Chip-Seq_Bcells_Human1.28397505
66* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.26969486
67WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26061992
68* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25821835
69MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.25715272
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24783695
71ATF3_27146783_Chip-Seq_COLON_Human1.24684079
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.24208750
73* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.24133319
74IRF8_22096565_ChIP-ChIP_GC-B_Human1.23126531
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22805443
76SA1_27219007_Chip-Seq_Bcells_Human1.22734256
77CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22451619
78UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22401131
79FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.22134328
80BCOR_27268052_Chip-Seq_Bcells_Human1.20790030
81TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.19596167
82* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19561390
83SMC4_20622854_ChIP-Seq_HELA_Human1.18417299
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17740674
85CTCF_21964334_Chip-Seq_Bcells_Human1.17697643
86RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17695898
87TP63_22573176_ChIP-Seq_HFKS_Human1.17039167
88FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.16988568
89RARB_27405468_Chip-Seq_BRAIN_Mouse1.16983565
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16697177
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15573485
92GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15061434
93TET1_21451524_ChIP-Seq_MESCs_Mouse1.12431657
94SPI1_23127762_ChIP-Seq_K562_Human1.11258421
95* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11205498
96KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10824798
97E2F7_22180533_ChIP-Seq_HELA_Human1.10381064
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10172681
99RUNX1_22412390_ChIP-Seq_EML_Mouse1.09828268
100RARB_24833708_ChIP-Seq_LIVER_Mouse1.09720756
101STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09532517
102PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09525241
103TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09239278
104SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09052206
105PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08927238
106OCT4_19829295_ChIP-Seq_ESCs_Human1.07286721
107SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06674193
108* PHF8_20622854_ChIP-Seq_HELA_Human1.05153511
109ESR2_21235772_ChIP-Seq_MCF-7_Human1.05115150
110MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05062018
111TBX20_22080862_ChIP-Seq_HEART_Mouse1.04549173
112TBX20_22328084_ChIP-Seq_HEART_Mouse1.04549173
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04465225
114ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04431700
115SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04241695
116CTCF_26484167_Chip-Seq_Bcells_Mouse1.03378190
117* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03120913
118TP53_22127205_ChIP-Seq_IMR90_Human1.02676233
119ETS1_21867929_ChIP-Seq_TH2_Mouse1.02551392
120TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02026295
121MYB_26560356_Chip-Seq_TH1_Human1.01825914
122* RUNX1_27514584_Chip-Seq_MCF-7_Human1.01494311
123* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01335199
124SUZ12_27294783_Chip-Seq_ESCs_Mouse1.00879572
125RARA_24833708_ChIP-Seq_LIVER_Mouse1.00697432
126* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.00210232
127GATA1_19941826_ChIP-Seq_K562_Human0.99593259
128* E2F1_20622854_ChIP-Seq_HELA_Human0.98526231

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.19032486
2MP0008961_abnormal_basal_metabolism3.09734671
3MP0003172_abnormal_lysosome_physiology3.01235172
4MP0003436_decreased_susceptibility_to2.96284882
5MP0005360_urolithiasis2.93354136
6MP0000751_myopathy2.82648483
7MP0005058_abnormal_lysosome_morphology2.70334233
8MP0004130_abnormal_muscle_cell2.35412529
9MP0005365_abnormal_bile_salt2.34351717
10MP0005076_abnormal_cell_differentiation2.30651136
11MP0002139_abnormal_hepatobiliary_system2.25969020
12MP0002837_dystrophic_cardiac_calcinosis2.22532926
13MP0003300_gastrointestinal_ulcer2.13708724
14MP0008260_abnormal_autophagy2.07239793
15MP0009278_abnormal_bone_marrow2.07145403
16MP0003303_peritoneal_inflammation2.03065231
17MP0004084_abnormal_cardiac_muscle2.02110949
18MP0004087_abnormal_muscle_fiber1.98737618
19MP0009840_abnormal_foam_cell1.98256015
20MP0002249_abnormal_larynx_morphology1.93879892
21MP0005409_darkened_coat_color1.91760439
22MP0003183_abnormal_peptide_metabolism1.91722252
23MP0000678_abnormal_parathyroid_gland1.89077628
24MP0005085_abnormal_gallbladder_physiolo1.86860080
25MP0002269_muscular_atrophy1.83085045
26MP0010630_abnormal_cardiac_muscle1.77370413
27MP0003252_abnormal_bile_duct1.77241765
28MP0003646_muscle_fatigue1.76236612
29MP0003690_abnormal_glial_cell1.73356292
30MP0010352_gastrointestinal_tract_polyps1.68351676
31MP0005330_cardiomyopathy1.68198940
32MP0000747_muscle_weakness1.67307591
33MP0003279_aneurysm1.64915005
34MP0002933_joint_inflammation1.64486689
35MP0010329_abnormal_lipoprotein_level1.63249091
36MP0003879_abnormal_hair_cell1.61537971
37MP0002396_abnormal_hematopoietic_system1.60457794
38MP0004381_abnormal_hair_follicle1.60382392
39MP0004233_abnormal_muscle_weight1.57769748
40MP0001849_ear_inflammation1.57364518
41MP0004036_abnormal_muscle_relaxation1.56662874
42MP0001958_emphysema1.54115853
43MP0005083_abnormal_biliary_tract1.53755575
44MP0003724_increased_susceptibility_to1.53373393
45MP0005666_abnormal_adipose_tissue1.51663121
46MP0009333_abnormal_splenocyte_physiolog1.51289738
47MP0004185_abnormal_adipocyte_glucose1.50603750
48MP0003191_abnormal_cellular_cholesterol1.49895169
49MP0004947_skin_inflammation1.47649896
50MP0005025_abnormal_response_to1.44997744
51MP0002909_abnormal_adrenal_gland1.44086002
52MP0001790_abnormal_immune_system1.43267111
53MP0005387_immune_system_phenotype1.43267111
54MP0001800_abnormal_humoral_immune1.42883597
55MP0005451_abnormal_body_composition1.42439299
56MP0004808_abnormal_hematopoietic_stem1.41211360
57MP0000749_muscle_degeneration1.38548523
58MP0002106_abnormal_muscle_physiology1.37294164
59MP0005000_abnormal_immune_tolerance1.36094393
60MP0005375_adipose_tissue_phenotype1.35293946
61MP0000759_abnormal_skeletal_muscle1.34709149
62MP0000609_abnormal_liver_physiology1.33949175
63MP0000733_abnormal_muscle_development1.33576029
64MP0003566_abnormal_cell_adhesion1.32955054
65MP0002089_abnormal_postnatal_growth/wei1.31481548
66MP0002419_abnormal_innate_immunity1.31332148
67MP0006082_CNS_inflammation1.28458882
68MP0010155_abnormal_intestine_physiology1.26195466
69MP0008569_lethality_at_weaning1.26156430
70MP0001502_abnormal_circadian_rhythm1.26072520
71MP0003763_abnormal_thymus_physiology1.25699577
72MP0001533_abnormal_skeleton_physiology1.25003778
73MP0000750_abnormal_muscle_regeneration1.24657286
74MP0003221_abnormal_cardiomyocyte_apopto1.24322607
75MP0010234_abnormal_vibrissa_follicle1.24304561
76MP0002132_abnormal_respiratory_system1.23270593
77MP0000685_abnormal_immune_system1.22465910
78MP0003283_abnormal_digestive_organ1.22026436
79MP0009384_cardiac_valve_regurgitation1.19502367
80MP0002420_abnormal_adaptive_immunity1.17843928
81MP0002723_abnormal_immune_serum1.17436435
82MP0005671_abnormal_response_to1.17067203
83MP0002998_abnormal_bone_remodeling1.17014449
84MP0001819_abnormal_immune_cell1.16817814
85MP0005319_abnormal_enzyme/_coenzyme1.16660331
86MP0000003_abnormal_adipose_tissue1.13628937
87MP0005670_abnormal_white_adipose1.12712625
88MP0001545_abnormal_hematopoietic_system1.12274369
89MP0005397_hematopoietic_system_phenotyp1.12274369
90MP0003329_amyloid_beta_deposits1.09287507
91MP0004145_abnormal_muscle_electrophysio1.09149627
92MP0004859_abnormal_synaptic_plasticity1.07184754
93MP0008875_abnormal_xenobiotic_pharmacok1.06192301
94MP0001730_embryonic_growth_arrest1.04003831
95MP0005584_abnormal_enzyme/coenzyme_acti1.03826697
96MP0002452_abnormal_antigen_presenting1.02498150
97MP0009672_abnormal_birth_weight1.01881814
98MP0005385_cardiovascular_system_phenoty1.01830645
99MP0001544_abnormal_cardiovascular_syste1.01830645
100MP0000858_altered_metastatic_potential1.01431001
101MP0000266_abnormal_heart_morphology1.00822287
102MP0000703_abnormal_thymus_morphology1.00342708
103MP0000604_amyloidosis1.00101992
104MP0004197_abnormal_fetal_growth/weight/0.99199963
105MP0003806_abnormal_nucleotide_metabolis0.98935849
106MP0001835_abnormal_antigen_presentation0.98141665
107MP0003635_abnormal_synaptic_transmissio0.97008500
108MP0005423_abnormal_somatic_nervous0.96635974
109MP0008770_decreased_survivor_rate0.96407696
110MP0002405_respiratory_system_inflammati0.96337105
111MP0002118_abnormal_lipid_homeostasis0.95765770
112MP0000716_abnormal_immune_system0.95629272
113MP0002970_abnormal_white_adipose0.95508597
114MP0004858_abnormal_nervous_system0.95424624
115MP0002234_abnormal_pharynx_morphology0.94500390
116MP0000598_abnormal_liver_morphology0.94486980
117MP0003091_abnormal_cell_migration0.93877177
118MP0003567_abnormal_fetal_cardiomyocyte0.93653992
119MP0002971_abnormal_brown_adipose0.92988031
120MP0006036_abnormal_mitochondrial_physio0.92163556
121MP0005332_abnormal_amino_acid0.91781825
122MP0002398_abnormal_bone_marrow0.91468884
123MP0005369_muscle_phenotype0.90343213
124MP0004510_myositis0.89496992
125MP0001666_abnormal_nutrient_absorption0.88699036
126MP0003045_fibrosis0.88451627
127MP0000681_abnormal_thyroid_gland0.86882678
128MP0005620_abnormal_muscle_contractility0.86450384
129MP0001986_abnormal_taste_sensitivity0.85844740
130MP0002722_abnormal_immune_system0.84645710
131MP0002063_abnormal_learning/memory/cond0.83691096
132MP0003866_abnormal_defecation0.82891940
133MP0000013_abnormal_adipose_tissue0.82496315
134MP0002086_abnormal_extraembryonic_tissu0.82321484
135MP0001765_abnormal_ion_homeostasis0.82296550
136MP0002088_abnormal_embryonic_growth/wei0.81981973
137MP0000767_abnormal_smooth_muscle0.81915271
138MP0003984_embryonic_growth_retardation0.81727855
139MP0002254_reproductive_system_inflammat0.80764339
140MP0000920_abnormal_myelination0.80668371
141MP0001663_abnormal_digestive_system0.80653782
142MP0001348_abnormal_lacrimal_gland0.80316330
143MP0002080_prenatal_lethality0.79923977
144MP0005166_decreased_susceptibility_to0.79706078
145MP0004215_abnormal_myocardial_fiber0.79313156
146MP0005023_abnormal_wound_healing0.79301678
147MP0006138_congestive_heart_failure0.78368631
148MP0000689_abnormal_spleen_morphology0.78102551
149MP0001873_stomach_inflammation0.77075073
150MP0002653_abnormal_ependyma_morphology0.76944757
151MP0002822_catalepsy0.76138654
152MP0008874_decreased_physiological_sensi0.75558743
153MP0010368_abnormal_lymphatic_system0.75309207
154MP0003453_abnormal_keratinocyte_physiol0.74805703
155MP0002429_abnormal_blood_cell0.74801762
156MP0005390_skeleton_phenotype0.74622300
157MP0003115_abnormal_respiratory_system0.73731474
158MP0003119_abnormal_digestive_system0.72065165
159MP0002972_abnormal_cardiac_muscle0.72023476
160MP0005464_abnormal_platelet_physiology0.71371361
161MP0005535_abnormal_body_temperature0.69919940
162MP0003634_abnormal_glial_cell0.69365429
163MP0002064_seizures0.66545709

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)4.90848698
2Hyperacusis (HP:0010780)4.18720303
3Exercise-induced myalgia (HP:0003738)3.44020358
4Abnormality of the lower motor neuron (HP:0002366)3.41888226
5Thin bony cortex (HP:0002753)3.24364510
6Myoglobinuria (HP:0002913)3.09330623
7Broad face (HP:0000283)3.01800105
8Stridor (HP:0010307)2.97288569
9Exercise-induced muscle cramps (HP:0003710)2.91299342
10Eczematoid dermatitis (HP:0000976)2.87548704
11Cerebral aneurysm (HP:0004944)2.87485694
12Difficulty running (HP:0009046)2.79947799
13Supranuclear gaze palsy (HP:0000605)2.76855203
14Hemorrhage of the eye (HP:0011885)2.75039822
15J-shaped sella turcica (HP:0002680)2.74611138
16Sudden death (HP:0001699)2.72022275
17Deep venous thrombosis (HP:0002625)2.70721903
18Insomnia (HP:0100785)2.69350338
19Upper limb amyotrophy (HP:0009129)2.65371827
20Distal upper limb amyotrophy (HP:0007149)2.65371827
21Elfin facies (HP:0004428)2.62598705
22Lymphangioma (HP:0100764)2.61254765
23Cervical subluxation (HP:0003308)2.53461433
24Asymmetric septal hypertrophy (HP:0001670)2.48442714
25Ketosis (HP:0001946)2.47336948
26Dysostosis multiplex (HP:0000943)2.44218121
27Dysmetric saccades (HP:0000641)2.43556835
28Hand muscle atrophy (HP:0009130)2.41917247
29Hyporeflexia of lower limbs (HP:0002600)2.41492121
30Increased connective tissue (HP:0009025)2.40468243
31Ulnar deviation of the wrist (HP:0003049)2.39627821
32Biconcave vertebral bodies (HP:0004586)2.39242166
33Ketoacidosis (HP:0001993)2.39167563
34Emphysema (HP:0002097)2.38647698
35Ankle clonus (HP:0011448)2.37527241
36Difficulty climbing stairs (HP:0003551)2.35229756
37Distal lower limb amyotrophy (HP:0008944)2.34042564
38Urinary glycosaminoglycan excretion (HP:0003541)2.31547893
39Mucopolysacchariduria (HP:0008155)2.31547893
40Type 1 muscle fiber predominance (HP:0003803)2.30371065
41Renovascular hypertension (HP:0100817)2.29282304
42Easy fatigability (HP:0003388)2.29222611
43Spinal canal stenosis (HP:0003416)2.27414041
44Papilledema (HP:0001085)2.26775495
45Metaphyseal cupping (HP:0003021)2.26584558
46Ventricular tachycardia (HP:0004756)2.25351243
47Abnormality of polysaccharide metabolism (HP:0011012)2.22732757
48Abnormality of glycosaminoglycan metabolism (HP:0004371)2.22732757
49Abnormality of mucopolysaccharide metabolism (HP:0011020)2.22732757
50Increased IgE level (HP:0003212)2.21562142
51Joint stiffness (HP:0001387)2.21338742
52Hypercortisolism (HP:0001578)2.21103100
53Rhabdomyolysis (HP:0003201)2.20935083
54EMG: neuropathic changes (HP:0003445)2.19536735
55Ependymoma (HP:0002888)2.16308945
56Limb-girdle muscle atrophy (HP:0003797)2.15868867
57Cellulitis (HP:0100658)2.15607144
58Abnormality of the Achilles tendon (HP:0005109)2.15082033
59Atrioventricular block (HP:0001678)2.14429636
60Subaortic stenosis (HP:0001682)2.12079568
61Abnormality of the left ventricular outflow tract (HP:0011103)2.12079568
62Polycythemia (HP:0001901)2.11430571
63Abnormality of the thoracic spine (HP:0100711)2.10576341
64Macroorchidism (HP:0000053)2.10443067
65Gastrointestinal infarctions (HP:0005244)2.09888722
66Renal duplication (HP:0000075)2.09203212
67Disproportionate tall stature (HP:0001519)2.08238962
68Broad metatarsal (HP:0001783)2.08056541
69Myositis (HP:0100614)2.06311998
70Pointed chin (HP:0000307)2.06242293
71Verrucae (HP:0200043)2.06124104
72Papilloma (HP:0012740)2.06124104
73Flat acetabular roof (HP:0003180)2.05435225
74Enlarged penis (HP:0000040)2.04732475
75Bundle branch block (HP:0011710)2.04601490
76Achilles tendon contracture (HP:0001771)2.03106991
77Malnutrition (HP:0004395)2.01448369
78Mitral regurgitation (HP:0001653)2.00684784
79Myopathic facies (HP:0002058)2.00489254
80Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.00396242
81Long toe (HP:0010511)1.99950492
82Neurofibrillary tangles (HP:0002185)1.99933075
83Frequent falls (HP:0002359)1.99539812
84Late onset (HP:0003584)1.99232550
85Aneurysm (HP:0002617)1.98730947
86Turricephaly (HP:0000262)1.98417124
87Gastrointestinal stroma tumor (HP:0100723)1.97369407
88Increased variability in muscle fiber diameter (HP:0003557)1.95686736
89Abnormality of skeletal muscle fiber size (HP:0012084)1.95671933
90Angiofibromas (HP:0010615)1.95195188
91Adenoma sebaceum (HP:0009720)1.95195188
92Polygenic inheritance (HP:0010982)1.94722472
93Bronchomalacia (HP:0002780)1.94418181
94Abnormality of the nasal mucosa (HP:0000433)1.94336201
95Pseudobulbar signs (HP:0002200)1.93924042
96Neoplasm of the heart (HP:0100544)1.93087987
97Atelectasis (HP:0100750)1.90691425
98Abnormality of the fingertips (HP:0001211)1.90109917
99Round ear (HP:0100830)1.89801066
100EMG: myopathic abnormalities (HP:0003458)1.88890433
101Neuronal loss in central nervous system (HP:0002529)1.87290148
102Hyperammonemia (HP:0001987)1.87175005
103Thin ribs (HP:0000883)1.86135916
104Ragged-red muscle fibers (HP:0003200)1.85692275
105Centrally nucleated skeletal muscle fibers (HP:0003687)1.85634808
106Segmental peripheral demyelination/remyelination (HP:0003481)1.85606117
107Thoracic kyphosis (HP:0002942)1.85585046
108Inflammation of the large intestine (HP:0002037)1.85570545
109Agammaglobulinemia (HP:0004432)1.85549381
110Neonatal onset (HP:0003623)1.85148707
111Multiple enchondromatosis (HP:0005701)1.84885125
112Distal lower limb muscle weakness (HP:0009053)1.84866705
113Ulnar bowing (HP:0003031)1.84396827
114Overriding aorta (HP:0002623)1.84374793
115Right ventricular cardiomyopathy (HP:0011663)1.83320222
116Onion bulb formation (HP:0003383)1.83176172
117Gastrointestinal inflammation (HP:0004386)1.82704988
118Colitis (HP:0002583)1.82507114
119Nasal polyposis (HP:0100582)1.82476404
120Gout (HP:0001997)1.82216175
121Muscle fiber inclusion bodies (HP:0100299)1.80165735
122Ventricular fibrillation (HP:0001663)1.79729448
123Spontaneous hematomas (HP:0007420)1.79693466
124Shallow orbits (HP:0000586)1.79611909
125Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.78915804
126Muscle fiber splitting (HP:0003555)1.78647479
127Vertebral arch anomaly (HP:0008438)1.78099297
128Annular pancreas (HP:0001734)1.77852406
129Broad palm (HP:0001169)1.76656878
130Hamartoma of the eye (HP:0010568)1.76013270
131Long palpebral fissure (HP:0000637)1.75974942
132Gingivitis (HP:0000230)1.75938214
133Mildly elevated creatine phosphokinase (HP:0008180)1.75930430
134Pustule (HP:0200039)1.74998376
135Hemiplegia (HP:0002301)1.73369827
136Recurrent fungal infections (HP:0002841)1.73160139
137Visceral angiomatosis (HP:0100761)1.72778854
138Spastic diplegia (HP:0001264)1.72507158
139Rectal prolapse (HP:0002035)1.72103236
140Hypertriglyceridemia (HP:0002155)1.72076765
141Increased density of long bones (HP:0006392)1.72050339
142Bulbar palsy (HP:0001283)1.70811116
143Calf muscle hypertrophy (HP:0008981)1.70153972
144Abnormality of the 4th metacarpal (HP:0010012)1.69752022
145Back pain (HP:0003418)1.68653405
146Deformed sella turcica (HP:0002681)1.68502044
147Supernumerary nipples (HP:0002558)1.67870861
148Xanthomatosis (HP:0000991)1.67660223
149Lower limb amyotrophy (HP:0007210)1.67020206
150Fibroma (HP:0010614)1.66928594
151Aortic regurgitation (HP:0001659)1.66568143
152Dislocated radial head (HP:0003083)1.66480233
153Sleep apnea (HP:0010535)1.65935089
154Systemic lupus erythematosus (HP:0002725)1.65902073
155Diplopia (HP:0000651)1.65610533
156Abnormality of binocular vision (HP:0011514)1.65610533
157Gastrointestinal dysmotility (HP:0002579)1.65554506
158Growth hormone excess (HP:0000845)1.65494059
159Meningitis (HP:0001287)1.65489861
160Nuclear cataract (HP:0100018)1.65284520
161Heart block (HP:0012722)1.63850426
162Precocious puberty (HP:0000826)1.63171426
163Abnormality of endocrine pancreas physiology (HP:0012093)1.62963739
164Abnormality of the pancreatic islet cells (HP:0006476)1.62963739
165Myotonia (HP:0002486)1.62449088
166Chest pain (HP:0100749)1.61657689
167Hypoglycemic coma (HP:0001325)1.61102257
168Fibrous tissue neoplasm (HP:0012316)1.60354255
169Protrusio acetabuli (HP:0003179)1.59204457
170Mesangial abnormality (HP:0001966)1.59044031
171Progressive muscle weakness (HP:0003323)1.58935397
172Abnormality of the astrocytes (HP:0100707)1.58779424

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.19009565
2PKN24.25502571
3MAP3K103.70338537
4EEF2K3.54645788
5ERN13.11040766
6PRPF4B3.02596358
7TTN2.39165303
8MAP3K132.16026836
9MAP4K12.09497941
10SIK22.08714630
11SMG12.05464910
12SIK11.95629805
13TAOK11.95498636
14RIPK41.88672164
15RIPK11.88324411
16BCKDK1.84209919
17ICK1.82125224
18TNK21.79511411
19CDK121.79292541
20FGFR41.70197409
21PTK61.68360318
22MAP3K71.60625806
23LRRK21.58817100
24GRK61.52559722
25LMTK21.47036120
26NEK11.35868440
27TYRO31.34855900
28MAP2K31.25662584
29ALK1.13607347
30PDGFRA1.12261974
31PHKG21.12046342
32PHKG11.12046342
33MAPK151.09802317
34PRKD31.05588901
35MTOR1.05574017
36FLT31.03953211
37DMPK1.00598449
38STK100.98441039
39MARK20.94436653
40ZAP700.94302763
41NEK20.93773698
42IRAK40.93539998
43CDK40.90070290
44BLK0.89602998
45MAP2K20.89536590
46CAMK1G0.87748348
47RPS6KC10.86721089
48RPS6KL10.86721089
49KSR20.86633954
50RET0.82819535
51NTRK30.82503732
52MAP3K30.80741359
53PRKCH0.80684706
54PAK40.80555385
55CAMKK10.80278191
56BMX0.80007956
57MAPK70.78680864
58MAP3K10.78578260
59MAP3K90.78454927
60TYK20.77742306
61CSK0.77051640
62MAP3K140.76911559
63JAK30.76529240
64CAMK1D0.75317098
65TGFBR20.74457539
66DYRK1B0.73718221
67SIK30.73701240
68MAPK110.73549182
69MAPKAPK30.73351031
70DAPK20.72926090
71MAP3K60.72604898
72RPS6KA60.72350799
73RPS6KB20.72280738
74MAP3K110.71928384
75BTK0.70011576
76TGFBR10.69319825
77PRKD20.65888257
78CDK60.65457187
79ILK0.64970571
80NTRK10.63299847
81HCK0.62937876
82SCYL20.62842711
83PAK60.62258708
84MAPK120.59564818
85PDK10.59375536
86JAK10.58989186
87PTK20.57849235
88JAK20.57197570
89FGFR30.57166313
90EPHB10.56924565
91NTRK20.54885757
92CSF1R0.54865544
93PAK20.54422033
94STK380.53947315
95IKBKE0.53591635
96HIPK20.53437910
97MAP3K80.53189816
98ITK0.51620237
99TBK10.51574989
100DDR20.51399591
101CAMK40.50944492
102CDC42BPA0.50448424
103PRKD10.49513593
104SGK2230.49184807
105SGK4940.49184807
106DAPK10.48286779
107TAOK20.45976036
108PDK30.45746785
109PDK40.45746785
110EPHA20.44857776
111MAPK40.44309283
112RPS6KA20.44290631
113FGR0.43742766
114SYK0.43637737
115LCK0.42627632
116IRAK30.41547574
117PDPK10.41538460
118KSR10.41152590
119RPS6KA10.40865177
120CAMK10.40624716
121STK110.40305754
122PRKAA10.40059484
123FYN0.39944684
124IRAK20.39755120
125MAP2K40.39713635
126MARK30.39692779
127UHMK10.39136580
128TESK10.38970748
129MAP2K60.38801410
130SGK30.38352844
131MAPK80.38119037
132BRD40.37909147
133AKT20.37906834
134FGFR10.37372624
135LATS20.35632829
136FES0.35465017

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.40354928
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.99757067
3Nitrogen metabolism_Homo sapiens_hsa009102.89317926
4Other glycan degradation_Homo sapiens_hsa005112.84821704
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.51171908
6Lysine degradation_Homo sapiens_hsa003102.15672422
7Fatty acid degradation_Homo sapiens_hsa000712.06219648
8Arginine biosynthesis_Homo sapiens_hsa002201.93448372
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.68131259
10Carbon metabolism_Homo sapiens_hsa012001.67484228
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.66232055
12Biosynthesis of amino acids_Homo sapiens_hsa012301.64914232
13Primary bile acid biosynthesis_Homo sapiens_hsa001201.58315867
14Insulin resistance_Homo sapiens_hsa049311.54221324
15GnRH signaling pathway_Homo sapiens_hsa049121.51185007
16Fatty acid metabolism_Homo sapiens_hsa012121.47236174
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.37438413
18Chronic myeloid leukemia_Homo sapiens_hsa052201.36649916
19mTOR signaling pathway_Homo sapiens_hsa041501.34221421
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33537213
21Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.33476242
22Bile secretion_Homo sapiens_hsa049761.33313574
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31715353
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.31041991
25Central carbon metabolism in cancer_Homo sapiens_hsa052301.29276543
26Propanoate metabolism_Homo sapiens_hsa006401.25410696
27B cell receptor signaling pathway_Homo sapiens_hsa046621.24968244
28Insulin signaling pathway_Homo sapiens_hsa049101.24924716
29Tryptophan metabolism_Homo sapiens_hsa003801.20966282
30Acute myeloid leukemia_Homo sapiens_hsa052211.20665547
31Glucagon signaling pathway_Homo sapiens_hsa049221.19778735
32Primary immunodeficiency_Homo sapiens_hsa053401.19465511
33Choline metabolism in cancer_Homo sapiens_hsa052311.18584162
34Long-term potentiation_Homo sapiens_hsa047201.17828865
35Leishmaniasis_Homo sapiens_hsa051401.17632340
36PPAR signaling pathway_Homo sapiens_hsa033201.17392694
37Non-small cell lung cancer_Homo sapiens_hsa052231.14740092
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.13462575
39Adipocytokine signaling pathway_Homo sapiens_hsa049201.11880299
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10421361
41VEGF signaling pathway_Homo sapiens_hsa043701.10193100
42Notch signaling pathway_Homo sapiens_hsa043301.07440982
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.06800915
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05615164
45AMPK signaling pathway_Homo sapiens_hsa041521.04747160
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04641187
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04301937
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03947649
49Selenocompound metabolism_Homo sapiens_hsa004501.03625084
50Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01792765
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.01096423
52Longevity regulating pathway - mammal_Homo sapiens_hsa042111.00018603
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99880230
54Dilated cardiomyopathy_Homo sapiens_hsa054140.97072625
55Pyruvate metabolism_Homo sapiens_hsa006200.96086759
56* Neurotrophin signaling pathway_Homo sapiens_hsa047220.95421268
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94271398
58Inositol phosphate metabolism_Homo sapiens_hsa005620.93904031
59ErbB signaling pathway_Homo sapiens_hsa040120.92598452
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91731259
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.91586534
62Chemokine signaling pathway_Homo sapiens_hsa040620.91380624
63Butanoate metabolism_Homo sapiens_hsa006500.91379626
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91312048
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90554851
66Toxoplasmosis_Homo sapiens_hsa051450.90422251
67Viral myocarditis_Homo sapiens_hsa054160.88995130
68Staphylococcus aureus infection_Homo sapiens_hsa051500.88136442
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87891808
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87064220
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86578527
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86398665
73Prion diseases_Homo sapiens_hsa050200.86200388
74Endometrial cancer_Homo sapiens_hsa052130.85940566
75Cholinergic synapse_Homo sapiens_hsa047250.85366023
76Prolactin signaling pathway_Homo sapiens_hsa049170.85220992
77Type II diabetes mellitus_Homo sapiens_hsa049300.84436158
78MAPK signaling pathway_Homo sapiens_hsa040100.82679006
79Endocytosis_Homo sapiens_hsa041440.81235410
80Hepatitis C_Homo sapiens_hsa051600.80764946
81TNF signaling pathway_Homo sapiens_hsa046680.79770559
82Pentose phosphate pathway_Homo sapiens_hsa000300.79209989
83Tuberculosis_Homo sapiens_hsa051520.78484010
84Glioma_Homo sapiens_hsa052140.78105850
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76602205
86Starch and sucrose metabolism_Homo sapiens_hsa005000.76576346
87Galactose metabolism_Homo sapiens_hsa000520.74206850
88T cell receptor signaling pathway_Homo sapiens_hsa046600.73860926
89Insulin secretion_Homo sapiens_hsa049110.72415557
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70332588
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.70073448
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68036605
93Influenza A_Homo sapiens_hsa051640.67698948
94Proteoglycans in cancer_Homo sapiens_hsa052050.67417361
95Synaptic vesicle cycle_Homo sapiens_hsa047210.67177633
96Estrogen signaling pathway_Homo sapiens_hsa049150.65292114
97Thyroid cancer_Homo sapiens_hsa052160.65255072
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64318311
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.63411104
100Melanogenesis_Homo sapiens_hsa049160.63209340
101Rap1 signaling pathway_Homo sapiens_hsa040150.62753141
102Platelet activation_Homo sapiens_hsa046110.62447713
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.62362244
104Caffeine metabolism_Homo sapiens_hsa002320.61841718
105Sulfur relay system_Homo sapiens_hsa041220.61759109
106HIF-1 signaling pathway_Homo sapiens_hsa040660.61582670
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60934009
108ABC transporters_Homo sapiens_hsa020100.60387813
109Colorectal cancer_Homo sapiens_hsa052100.60172004
110Hepatitis B_Homo sapiens_hsa051610.59562696
111Circadian entrainment_Homo sapiens_hsa047130.59236603
112Fat digestion and absorption_Homo sapiens_hsa049750.59056961
113Autoimmune thyroid disease_Homo sapiens_hsa053200.58930282
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.58193050
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57654528
116beta-Alanine metabolism_Homo sapiens_hsa004100.57634613
117Allograft rejection_Homo sapiens_hsa053300.57528334
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57465274
119Graft-versus-host disease_Homo sapiens_hsa053320.57425983
120Lysosome_Homo sapiens_hsa041420.57085380
121Fructose and mannose metabolism_Homo sapiens_hsa000510.56130275
122Amoebiasis_Homo sapiens_hsa051460.56005797
123Bladder cancer_Homo sapiens_hsa052190.55542039
124Focal adhesion_Homo sapiens_hsa045100.55439099
125Morphine addiction_Homo sapiens_hsa050320.55295631
126Fatty acid biosynthesis_Homo sapiens_hsa000610.55279098
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55020222
128Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54295946
129Glycerolipid metabolism_Homo sapiens_hsa005610.54041474
130Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53985963
131Cysteine and methionine metabolism_Homo sapiens_hsa002700.53424072
132Glutamatergic synapse_Homo sapiens_hsa047240.53177970
133Pertussis_Homo sapiens_hsa051330.52438363
134cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52234617
135FoxO signaling pathway_Homo sapiens_hsa040680.51977733
136Pancreatic cancer_Homo sapiens_hsa052120.51931658
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51718628
138Drug metabolism - other enzymes_Homo sapiens_hsa009830.51037416
139AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51031200
140Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49936369
141Gastric acid secretion_Homo sapiens_hsa049710.49527638
142Oxytocin signaling pathway_Homo sapiens_hsa049210.48044022
143HTLV-I infection_Homo sapiens_hsa051660.46305763
144Renal cell carcinoma_Homo sapiens_hsa052110.45898177
145Small cell lung cancer_Homo sapiens_hsa052220.45821966
146Complement and coagulation cascades_Homo sapiens_hsa046100.44802926
147Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44702534
148Phospholipase D signaling pathway_Homo sapiens_hsa040720.44525007
149Osteoclast differentiation_Homo sapiens_hsa043800.44337996

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