SH2B2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by organism of defense response of other organism involved in symbiotic interact6.43543709
2modulation by symbiont of host immune response (GO:0052553)6.43543709
3positive regulation by symbiont of host defense response (GO:0052509)6.43543709
4modulation by symbiont of host defense response (GO:0052031)6.43543709
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.43543709
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.43543709
7negative regulation of phagocytosis (GO:0050765)5.59184429
8negative regulation of cell killing (GO:0031342)5.15719844
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.15719844
10neutrophil mediated immunity (GO:0002446)5.13317022
11response to peptidoglycan (GO:0032494)5.08107077
12negative regulation of granulocyte differentiation (GO:0030853)4.82171282
13macrophage activation involved in immune response (GO:0002281)4.65432467
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.56479541
15low-density lipoprotein particle clearance (GO:0034383)4.47897374
16respiratory burst (GO:0045730)4.44161827
17antigen processing and presentation of endogenous antigen (GO:0019883)4.36748008
18detection of molecule of bacterial origin (GO:0032490)4.36180729
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.35426067
20cellular response to zinc ion (GO:0071294)4.34363788
21detection of other organism (GO:0098543)4.33091845
22regulation of interferon-beta biosynthetic process (GO:0045357)4.31636175
23response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.29596176
24response to host immune response (GO:0052572)4.29596176
25B cell receptor signaling pathway (GO:0050853)4.24060537
26detection of bacterium (GO:0016045)4.22564108
27negative regulation of interleukin-12 production (GO:0032695)4.18174135
28neutrophil activation involved in immune response (GO:0002283)4.18128494
29negative regulation of mast cell activation (GO:0033004)4.17352706
30response to muramyl dipeptide (GO:0032495)4.06532480
31microglial cell activation (GO:0001774)4.02012428
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.00437590
33regulation of sequestering of triglyceride (GO:0010889)3.97017524
34regulation of B cell receptor signaling pathway (GO:0050855)3.93931877
35immunoglobulin mediated immune response (GO:0016064)3.93872252
36positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.87884558
37response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.85812296
38response to host (GO:0075136)3.85812296
39response to host defenses (GO:0052200)3.85812296
40myeloid leukocyte mediated immunity (GO:0002444)3.81771312
41regulation of mast cell degranulation (GO:0043304)3.80853549
42cellular extravasation (GO:0045123)3.76155357
43positive regulation of antigen processing and presentation (GO:0002579)3.73232172
44response to protozoan (GO:0001562)3.73135616
45positive regulation of heat generation (GO:0031652)3.72282692
46regulation of gamma-delta T cell activation (GO:0046643)3.68116903
47superoxide anion generation (GO:0042554)3.67097068
48regulation of mast cell activation involved in immune response (GO:0033006)3.63103551
49white fat cell differentiation (GO:0050872)3.62005139
50regulation of T-helper 2 cell differentiation (GO:0045628)3.61815825
51cellular response to type I interferon (GO:0071357)3.57741324
52type I interferon signaling pathway (GO:0060337)3.57741324
53daunorubicin metabolic process (GO:0044597)3.55562702
54polyketide metabolic process (GO:0030638)3.55562702
55doxorubicin metabolic process (GO:0044598)3.55562702
56negative regulation of growth of symbiont in host (GO:0044130)3.54219186
57negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.54219186
58modulation of growth of symbiont involved in interaction with host (GO:0044144)3.54219186
59regulation of growth of symbiont in host (GO:0044126)3.54219186
60negative regulation of lipid storage (GO:0010888)3.53817321
61response to type I interferon (GO:0034340)3.53110141
62macrophage activation (GO:0042116)3.51690457
63positive regulation of interferon-alpha production (GO:0032727)3.51522394
64germinal center formation (GO:0002467)3.50818029
65* brown fat cell differentiation (GO:0050873)3.49555290
66regulation of dendritic cell antigen processing and presentation (GO:0002604)3.47617442
67positive regulation of chemokine biosynthetic process (GO:0045080)3.47043008
68lipopolysaccharide-mediated signaling pathway (GO:0031663)3.40543341
69regulation of mast cell activation (GO:0033003)3.39981689
70regulation of interferon-alpha production (GO:0032647)3.38522915
71positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.37759042
72positive regulation of B cell differentiation (GO:0045579)3.37661760
73regulation of cholesterol storage (GO:0010885)3.35066221
74neutrophil activation (GO:0042119)3.32122687
75production of molecular mediator involved in inflammatory response (GO:0002532)3.29706103
76T-helper 1 type immune response (GO:0042088)3.26867463
77interferon-gamma-mediated signaling pathway (GO:0060333)3.26325824
78granulocyte activation (GO:0036230)3.21409765
79negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.20193745
80negative regulation of toll-like receptor signaling pathway (GO:0034122)3.20026215
81positive regulation of gamma-delta T cell activation (GO:0046645)3.19581835
82leukocyte aggregation (GO:0070486)3.17499829
83negative regulation of erythrocyte differentiation (GO:0045647)3.17450215
84regulation of myeloid cell apoptotic process (GO:0033032)3.16653713
85regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.16616446
86myeloid dendritic cell differentiation (GO:0043011)3.16258001
87regulation of interleukin-8 biosynthetic process (GO:0045414)3.15968129
88negative regulation of lymphocyte mediated immunity (GO:0002707)3.15282277
89leukocyte migration involved in inflammatory response (GO:0002523)3.12317987
90positive thymic T cell selection (GO:0045059)3.11329289
91positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.10984151
92regulation of myeloid leukocyte mediated immunity (GO:0002886)3.10412261
93positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.08906948
94positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.08892103
95detection of external biotic stimulus (GO:0098581)3.08576108
96detection of biotic stimulus (GO:0009595)3.03861093
97regulation of chemokine biosynthetic process (GO:0045073)3.03718737
98positive regulation of mast cell activation involved in immune response (GO:0033008)3.02156070
99positive regulation of mast cell degranulation (GO:0043306)3.02156070
1003-UTR-mediated mRNA stabilization (GO:0070935)3.01630135
101positive regulation of type 2 immune response (GO:0002830)3.01616693
102regulation of antigen processing and presentation (GO:0002577)3.00983727
103leukocyte mediated cytotoxicity (GO:0001909)3.00754225
104regulation of B cell differentiation (GO:0045577)2.97831998
105negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.96455035
106lipid storage (GO:0019915)2.96092522
107negative regulation of leukocyte mediated immunity (GO:0002704)2.95926828
108myeloid cell activation involved in immune response (GO:0002275)2.95283500
109regulation of leukocyte degranulation (GO:0043300)2.92700313
110myeloid dendritic cell activation (GO:0001773)2.90374937
111regulation of gamma-delta T cell differentiation (GO:0045586)2.89952491
112* B cell homeostasis (GO:0001782)2.89771693
113regulation of granulocyte differentiation (GO:0030852)2.89679707
114defense response to protozoan (GO:0042832)2.89486345
115positive regulation of mast cell activation (GO:0033005)2.88437884
116macrophage differentiation (GO:0030225)2.87864078
117disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.87333407
118killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.87333407
119I-kappaB phosphorylation (GO:0007252)2.87186258
120T cell migration (GO:0072678)2.85681749
121regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.85470843
122positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.84202342
123CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.83523160
124reactive oxygen species biosynthetic process (GO:1903409)2.83019621
125B cell mediated immunity (GO:0019724)2.81097243
126positive regulation of cellular amide metabolic process (GO:0034250)2.80081736
127regulation of fever generation (GO:0031620)2.79957985
128negative regulation of alpha-beta T cell activation (GO:0046636)2.79766331
129positive regulation of interleukin-1 beta secretion (GO:0050718)2.79610159
130positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.79043498
131histamine secretion (GO:0001821)2.78803149
132positive regulation of chemokine production (GO:0032722)2.78616087
133modulation by symbiont of host cellular process (GO:0044068)2.78597729
134negative regulation of interleukin-6 production (GO:0032715)2.77758893
135Arp2/3 complex-mediated actin nucleation (GO:0034314)2.72925575
136positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.71421766
137NIK/NF-kappaB signaling (GO:0038061)2.70718310
138regulation of lipid storage (GO:0010883)2.70324371
139regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.70198845
140response to interleukin-15 (GO:0070672)2.69130128
141negative regulation of cytokine production involved in immune response (GO:0002719)2.69070678
142negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.68307428
143negative regulation of T-helper cell differentiation (GO:0045623)2.68307428

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.71122370
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.72975665
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.01148587
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.35000813
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.09543484
6SCL_19346495_ChIP-Seq_HPC-7_Human4.05526450
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.96479912
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.91406012
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.85010416
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.65650384
11MYB_21317192_ChIP-Seq_ERMYB_Mouse3.60726518
12* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.41806020
13E2F7_22180533_ChIP-Seq_HELA_Human3.18144262
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.12896223
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.04740873
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.93526470
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.83336262
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.77066287
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.69908151
20VDR_24763502_ChIP-Seq_THP-1_Human2.69289652
21VDR_21846776_ChIP-Seq_THP-1_Human2.64359576
22* LXR_22292898_ChIP-Seq_THP-1_Human2.55173293
23* SPI1_23547873_ChIP-Seq_NB4_Human2.47953302
24BRD4_27068464_Chip-Seq_AML-cells_Mouse2.41582931
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.29592781
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.28463756
27STAT6_21828071_ChIP-Seq_BEAS2B_Human2.12916818
28* MYC_22102868_ChIP-Seq_BL_Human2.06656763
29VDR_24787735_ChIP-Seq_THP-1_Human2.03613755
30SPI1_23127762_ChIP-Seq_K562_Human2.02546646
31RUNX_20019798_ChIP-Seq_JUKART_Human2.00462775
32PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.99702000
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.99345717
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.91901128
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.90198206
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.89004337
37FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.84935583
38* RUNX1_22412390_ChIP-Seq_EML_Mouse1.81828496
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.81329904
40* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.79604786
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.77703992
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.76150826
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63054829
44RACK7_27058665_Chip-Seq_MCF-7_Human1.62715654
45* TCF7_22412390_ChIP-Seq_EML_Mouse1.62591726
46PU_27001747_Chip-Seq_BMDM_Mouse1.61761015
47MAF_26560356_Chip-Seq_TH1_Human1.61727884
48* KDM2B_26808549_Chip-Seq_JURKAT_Human1.55733608
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55506938
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55310928
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.54108053
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53945455
53BCL6_27268052_Chip-Seq_Bcells_Human1.52713147
54CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.52156738
55P68_20966046_ChIP-Seq_HELA_Human1.52092429
56MYB_26560356_Chip-Seq_TH2_Human1.50537722
57* KDM2B_26808549_Chip-Seq_K562_Human1.48398230
58PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47876311
59FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.47484829
60BCOR_27268052_Chip-Seq_Bcells_Human1.46769332
61* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46654502
62* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45612962
63CTCF_27219007_Chip-Seq_ERYTHROID_Human1.44565620
64* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.43792614
65SA1_27219007_Chip-Seq_ERYTHROID_Human1.39635796
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.38882950
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.37128265
68ELF1_20517297_ChIP-Seq_JURKAT_Human1.32544932
69* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32475598
70UTX_26944678_Chip-Seq_JUKART_Human1.32229493
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32129497
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.29526760
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.29247075
74GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.27937567
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27612381
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.27450622
77EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27100379
78* NOTCH1_21737748_ChIP-Seq_TLL_Human1.25354889
79* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23739138
80MYB_26560356_Chip-Seq_TH1_Human1.22856079
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22185318
82* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21726208
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20937063
84ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20413960
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.19875553
86* SMC4_20622854_ChIP-Seq_HELA_Human1.19418231
87CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18088303
88CTCF_26484167_Chip-Seq_Bcells_Mouse1.17255338
89DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17120067
90* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.15329824
91IGF1R_20145208_ChIP-Seq_DFB_Human1.12397746
92NCOR1_26117541_ChIP-Seq_K562_Human1.11664953
93RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11567731
94* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09646375
95ELK3_25401928_ChIP-Seq_HUVEC_Human1.06832140
96GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06639293
97* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06232974
98TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06093450
99GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06059720
100* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04370539
101DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04286315
102EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.03735255
103SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03157351
104* CREB1_26743006_Chip-Seq_LNCaP_Human1.01671074
105* SA1_27219007_Chip-Seq_Bcells_Human1.01643875
106CTCF_21964334_Chip-Seq_Bcells_Human1.00378700
107CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98720450
108UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96903172
109CIITA_25753668_ChIP-Seq_RAJI_Human0.96183265
110CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96151300
111PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.95285227
112* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92764546
113MAF_26560356_Chip-Seq_TH2_Human0.92324192
114HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90926872
115* KDM2B_26808549_Chip-Seq_DND41_Human0.90466429
116CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.86067186
117ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85040863
118TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82863263
119PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82370402
120GATA3_27048872_Chip-Seq_THYMUS_Human0.82103172
121SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78860947
122* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.78631501
123GATA1_19941827_ChIP-Seq_MEL_Mouse0.78143042
124PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78126301
125GATA3_26560356_Chip-Seq_TH2_Human0.76847588
126GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75752307
127SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73667331
128* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70815869
129CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.69843315
130TFEB_21752829_ChIP-Seq_HELA_Human0.68042397
131GATA2_19941826_ChIP-Seq_K562_Human0.63904669
132RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.63119027
133TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.62217784
134SPI1_20517297_ChIP-Seq_HL60_Human0.60181883
135* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.59614282
136TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.57578612

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose3.80301781
2MP0001835_abnormal_antigen_presentation3.65718425
3MP0000569_abnormal_digit_pigmentation3.57132803
4MP0005451_abnormal_body_composition3.56018379
5MP0003303_peritoneal_inflammation3.16955548
6MP0003436_decreased_susceptibility_to3.05232615
7MP0002419_abnormal_innate_immunity2.94889425
8MP0003724_increased_susceptibility_to2.87653898
9MP0005174_abnormal_tail_pigmentation2.68785544
10MP0009785_altered_susceptibility_to2.66347920
11MP0003172_abnormal_lysosome_physiology2.39120691
12* MP0002452_abnormal_antigen_presenting2.37737079
13MP0005000_abnormal_immune_tolerance2.36235516
14MP0005025_abnormal_response_to2.34084401
15MP0005387_immune_system_phenotype2.26727047
16MP0001790_abnormal_immune_system2.26727047
17MP0002148_abnormal_hypersensitivity_rea2.23591237
18* MP0001800_abnormal_humoral_immune2.21693652
19MP0005666_abnormal_adipose_tissue2.18794583
20MP0009278_abnormal_bone_marrow2.16928376
21MP0002396_abnormal_hematopoietic_system2.13631345
22MP0000015_abnormal_ear_pigmentation2.12480136
23MP0005464_abnormal_platelet_physiology2.08671356
24* MP0002723_abnormal_immune_serum2.02506067
25MP0003763_abnormal_thymus_physiology2.01829272
26* MP0002420_abnormal_adaptive_immunity2.01255506
27* MP0001819_abnormal_immune_cell2.00790008
28MP0004185_abnormal_adipocyte_glucose2.00024055
29MP0001545_abnormal_hematopoietic_system1.96013603
30MP0005397_hematopoietic_system_phenotyp1.96013603
31MP0000343_altered_response_to1.88915896
32MP0004510_myositis1.87317341
33MP0008260_abnormal_autophagy1.84809903
34MP0004130_abnormal_muscle_cell1.83532980
35MP0001533_abnormal_skeleton_physiology1.78213339
36MP0003191_abnormal_cellular_cholesterol1.76935145
37MP0005671_abnormal_response_to1.72426199
38MP0002971_abnormal_brown_adipose1.63314266
39MP0000685_abnormal_immune_system1.62788287
40MP0005058_abnormal_lysosome_morphology1.59882815
41MP0003183_abnormal_peptide_metabolism1.51646461
42MP0008438_abnormal_cutaneous_collagen1.50392503
43MP0005310_abnormal_salivary_gland1.49741765
44MP0005375_adipose_tissue_phenotype1.49022751
45MP0009115_abnormal_fat_cell1.48263847
46MP0003448_altered_tumor_morphology1.45840918
47MP0002405_respiratory_system_inflammati1.44785556
48MP0001845_abnormal_inflammatory_respons1.44753549
49* MP0000716_abnormal_immune_system1.43882861
50* MP0002398_abnormal_bone_marrow1.43266960
51MP0004381_abnormal_hair_follicle1.39533203
52MP0005076_abnormal_cell_differentiation1.36793107
53MP0001853_heart_inflammation1.36582122
54MP0002638_abnormal_pupillary_reflex1.36379884
55MP0000703_abnormal_thymus_morphology1.34808931
56MP0002332_abnormal_exercise_endurance1.33771611
57MP0005257_abnormal_intraocular_pressure1.30845461
58MP0006082_CNS_inflammation1.27417200
59MP0000750_abnormal_muscle_regeneration1.27258618
60MP0004808_abnormal_hematopoietic_stem1.27190672
61MP0002998_abnormal_bone_remodeling1.26292015
62* MP0002429_abnormal_blood_cell1.19630648
63MP0000371_diluted_coat_color1.19592379
64MP0005645_abnormal_hypothalamus_physiol1.18852875
65MP0003075_altered_response_to1.18745491
66MP0000689_abnormal_spleen_morphology1.17826908
67MP0002138_abnormal_hepatobiliary_system1.15048758
68MP0003828_pulmonary_edema1.14555794
69MP0004858_abnormal_nervous_system1.14412193
70MP0005334_abnormal_fat_pad1.14085062
71MP0002132_abnormal_respiratory_system1.14055712
72MP0009840_abnormal_foam_cell1.13392596
73MP0008469_abnormal_protein_level1.11753443
74MP0000747_muscle_weakness1.10317955
75MP0001873_stomach_inflammation1.09587298
76MP0009764_decreased_sensitivity_to1.08446267
77MP0002970_abnormal_white_adipose1.07786114
78MP0000858_altered_metastatic_potential1.07248438
79MP0003866_abnormal_defecation1.05979744
80MP0002166_altered_tumor_susceptibility1.03762905
81MP0002722_abnormal_immune_system1.03127885
82MP0001851_eye_inflammation1.03034583
83MP0001663_abnormal_digestive_system1.02669916
84MP0000465_gastrointestinal_hemorrhage1.02355926
85MP0000490_abnormal_crypts_of1.01966717
86MP0002933_joint_inflammation1.00780988
87MP0005164_abnormal_response_to1.00672741
88MP0005166_decreased_susceptibility_to1.00573020
89MP0005390_skeleton_phenotype1.00176388
90MP0002006_tumorigenesis0.99478049
91MP0009333_abnormal_splenocyte_physiolog0.99422616
92MP0003646_muscle_fatigue0.97906086
93MP0002277_abnormal_respiratory_mucosa0.97713769
94MP0010307_abnormal_tumor_latency0.94198644
95MP0004145_abnormal_muscle_electrophysio0.92603777
96MP0004233_abnormal_muscle_weight0.91386512
97MP0000249_abnormal_blood_vessel0.91071757
98MP0000759_abnormal_skeletal_muscle0.90509028
99MP0010155_abnormal_intestine_physiology0.88262331
100MP0003300_gastrointestinal_ulcer0.87385953
101MP0004883_abnormal_blood_vessel0.86051708
102MP0003705_abnormal_hypodermis_morpholog0.85119698
103MP0003221_abnormal_cardiomyocyte_apopto0.84644837
104MP0008874_decreased_physiological_sensi0.84481117
105MP0003453_abnormal_keratinocyte_physiol0.84374407
106MP0001879_abnormal_lymphatic_vessel0.83928725
107MP0002095_abnormal_skin_pigmentation0.83043559
108MP0008004_abnormal_stomach_pH0.81511186
109MP0003690_abnormal_glial_cell0.80332513
110MP0002106_abnormal_muscle_physiology0.79291909
111MP0000003_abnormal_adipose_tissue0.75352186
112MP0001849_ear_inflammation0.75047062
113MP0005535_abnormal_body_temperature0.74051243
114MP0002254_reproductive_system_inflammat0.73748740
115MP0005448_abnormal_energy_balance0.72088860
116MP0000749_muscle_degeneration0.70728479
117MP0009763_increased_sensitivity_to0.70298116
118MP0003091_abnormal_cell_migration0.70237865
119MP0002928_abnormal_bile_duct0.68620756
120MP0000678_abnormal_parathyroid_gland0.68162724
121MP0008961_abnormal_basal_metabolism0.66901224
122MP0005381_digestive/alimentary_phenotyp0.66533467
123MP0002075_abnormal_coat/hair_pigmentati0.66466779
124MP0009697_abnormal_copulation0.66365945
125MP0000681_abnormal_thyroid_gland0.65508741
126MP0005075_abnormal_melanosome_morpholog0.65298336
127MP0006292_abnormal_olfactory_placode0.65106756
128MP0004947_skin_inflammation0.64326879
129MP0003186_abnormal_redox_activity0.63380053
130MP0004087_abnormal_muscle_fiber0.63270802
131MP0003879_abnormal_hair_cell0.60931362
132MP0000604_amyloidosis0.60917200
133MP0001175_abnormal_lung_morphology0.60201683
134MP0003045_fibrosis0.59955414
135MP0002938_white_spotting0.59401251
136MP0000733_abnormal_muscle_development0.58545598
137MP0004036_abnormal_muscle_relaxation0.58332927
138MP0000751_myopathy0.58066148
139MP0002653_abnormal_ependyma_morphology0.57335022

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.30936209
2Recurrent bacterial skin infections (HP:0005406)5.63775699
3Elevated erythrocyte sedimentation rate (HP:0003565)5.33658520
4Eczematoid dermatitis (HP:0000976)4.95151134
5Myositis (HP:0100614)4.28336872
6Recurrent gram-negative bacterial infections (HP:0005420)4.24960619
7Gastrointestinal stroma tumor (HP:0100723)4.12111864
8Chronic obstructive pulmonary disease (HP:0006510)4.03141090
9Obstructive lung disease (HP:0006536)4.03141090
10Orchitis (HP:0100796)3.94424225
11Abnormality of macrophages (HP:0004311)3.90885912
12Mediastinal lymphadenopathy (HP:0100721)3.80124302
13Retrobulbar optic neuritis (HP:0100654)3.49894728
14Optic neuritis (HP:0100653)3.49894728
15Exercise-induced myalgia (HP:0003738)3.49299979
16Increased IgE level (HP:0003212)3.38208925
17Muscle fiber inclusion bodies (HP:0100299)3.36874619
18Hematochezia (HP:0002573)3.36248780
19Recurrent skin infections (HP:0001581)3.32541881
20Nemaline bodies (HP:0003798)3.22163051
21Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.17591642
22Cellulitis (HP:0100658)3.15946136
23Vasculitis (HP:0002633)3.15496288
24Lymphopenia (HP:0001888)3.11195417
25Gastrointestinal infarctions (HP:0005244)3.06945025
26Recurrent fungal infections (HP:0002841)3.05510750
27Gingivitis (HP:0000230)3.03867008
28Chronic otitis media (HP:0000389)3.03418381
29Systemic lupus erythematosus (HP:0002725)3.03190855
30Meningitis (HP:0001287)2.99280962
31Autoimmune thrombocytopenia (HP:0001973)2.95149819
32Encephalitis (HP:0002383)2.94401569
33Myopathic facies (HP:0002058)2.91156687
34Abnormality of cells of the lymphoid lineage (HP:0012140)2.86945090
35Recurrent sinusitis (HP:0011108)2.85922108
36Stomatitis (HP:0010280)2.81407138
37Centrally nucleated skeletal muscle fibers (HP:0003687)2.76937924
38Abnormality of liposaccharide metabolism (HP:0010968)2.75636299
39Abnormality of glycosphingolipid metabolism (HP:0004343)2.75636299
40Abnormality of glycolipid metabolism (HP:0010969)2.75636299
41Colitis (HP:0002583)2.68199998
42Inflammation of the large intestine (HP:0002037)2.65975161
43Thrombocytosis (HP:0001894)2.65543749
44Recurrent lower respiratory tract infections (HP:0002783)2.65128643
45Pulmonary infiltrates (HP:0002113)2.61713770
46Recurrent viral infections (HP:0004429)2.61637058
47Oligomenorrhea (HP:0000876)2.61530051
48Recurrent pneumonia (HP:0006532)2.60315883
49Difficulty running (HP:0009046)2.59125916
50Emphysema (HP:0002097)2.58934972
51Recurrent cutaneous fungal infections (HP:0011370)2.57614739
52Chronic mucocutaneous candidiasis (HP:0002728)2.57614739
53IgM deficiency (HP:0002850)2.57337998
54Basal ganglia calcification (HP:0002135)2.56761058
55Osteomyelitis (HP:0002754)2.56212527
56Abnormality of the prostate (HP:0008775)2.53198948
57Urticaria (HP:0001025)2.51333311
58Prolonged bleeding time (HP:0003010)2.49029523
59Spontaneous hematomas (HP:0007420)2.48950099
60Prostate neoplasm (HP:0100787)2.47835470
61Gastrointestinal inflammation (HP:0004386)2.47735955
62Cutaneous melanoma (HP:0012056)2.46961921
63Increased cerebral lipofuscin (HP:0011813)2.43357270
64Abnormality of skeletal muscle fiber size (HP:0012084)2.42844898
65Increased connective tissue (HP:0009025)2.38199390
66Hypochromic anemia (HP:0001931)2.36752920
67Hypertensive crisis (HP:0100735)2.36025095
68Increased IgM level (HP:0003496)2.35768794
69Panhypogammaglobulinemia (HP:0003139)2.34644109
70Reduced subcutaneous adipose tissue (HP:0003758)2.34476235
71Type 1 muscle fiber predominance (HP:0003803)2.33180219
72Spinal cord lesions (HP:0100561)2.33003113
73Syringomyelia (HP:0003396)2.33003113
74Tetraparesis (HP:0002273)2.31490200
75Leukocytosis (HP:0001974)2.31021958
76Hemoptysis (HP:0002105)2.29717707
77Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.29230107
78Albinism (HP:0001022)2.27998733
79Premature loss of primary teeth (HP:0006323)2.27922703
80Purpura (HP:0000979)2.24994607
81Bulbar palsy (HP:0001283)2.24964705
82Disinhibition (HP:0000734)2.23954610
83Papilloma (HP:0012740)2.23301537
84Verrucae (HP:0200043)2.23301537
85Periodontitis (HP:0000704)2.21817723
86Glomerulopathy (HP:0100820)2.20356773
87Increased variability in muscle fiber diameter (HP:0003557)2.20118491
88Abnormality of the pleura (HP:0002103)2.19942430
89J-shaped sella turcica (HP:0002680)2.19448236
90EMG: myopathic abnormalities (HP:0003458)2.19382123
91Abnormality of the lumbar spine (HP:0100712)2.18092382
92Hypertriglyceridemia (HP:0002155)2.15946584
93Ulnar deviation of the wrist (HP:0003049)2.14508521
94Episodic fever (HP:0001954)2.13287605
95Keratoconjunctivitis sicca (HP:0001097)2.12247694
96Increased neuronal autofluorescent lipopigment (HP:0002074)2.11997118
97Muscle fiber splitting (HP:0003555)2.11120600
98Recurrent bronchitis (HP:0002837)2.10796353
99Myocardial infarction (HP:0001658)2.08595886
100Bone pain (HP:0002653)2.08464955
101Increased serum ferritin (HP:0003281)2.07445349
102Ragged-red muscle fibers (HP:0003200)2.05988186
103Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.05907065
104Amyloidosis (HP:0011034)2.05294288
105Agammaglobulinemia (HP:0004432)2.01386775
106Asymmetric septal hypertrophy (HP:0001670)2.01119643
107Gingival bleeding (HP:0000225)2.00555772
108Nausea (HP:0002018)1.99562670
109Abnormality of the peritoneum (HP:0002585)1.99426097
110Viral hepatitis (HP:0006562)1.98444843
111Bone cyst (HP:0012062)1.98393907
112Arterial thrombosis (HP:0004420)1.97893538
113Easy fatigability (HP:0003388)1.97335146
114Restrictive lung disease (HP:0002091)1.96566351
115Thoracic kyphosis (HP:0002942)1.95130023
116Acrocyanosis (HP:0001063)1.95024362
117Abnormality of T cell physiology (HP:0011840)1.93652252
118Vacuolated lymphocytes (HP:0001922)1.93557667
119Abnormal delayed hypersensitivity skin test (HP:0002963)1.93355107
120Abnormality of mucopolysaccharide metabolism (HP:0011020)1.92804745
121Abnormality of polysaccharide metabolism (HP:0011012)1.92804745
122Abnormality of glycosaminoglycan metabolism (HP:0004371)1.92804745
123Abnormality of the endocardium (HP:0004306)1.92160149
124Distal lower limb muscle weakness (HP:0009053)1.92039819
125Rhabdomyolysis (HP:0003201)1.91936211
126Hypergammaglobulinemia (HP:0010702)1.91515706
127Distal arthrogryposis (HP:0005684)1.91007696
128Hyporeflexia of lower limbs (HP:0002600)1.89993453
129Abnormality of the fingertips (HP:0001211)1.89635281
130Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.88952432
131Chest pain (HP:0100749)1.88153901
132Agnosia (HP:0010524)1.87950679
133Deformed sella turcica (HP:0002681)1.87695840
134Exercise-induced muscle cramps (HP:0003710)1.87337673
135Keratoconjunctivitis (HP:0001096)1.86312565
136Cheilitis (HP:0100825)1.86271246
137Sepsis (HP:0100806)1.85055367
138Petechiae (HP:0000967)1.85043937
139Neoplasm of the adrenal cortex (HP:0100641)1.85024235
140Anorexia (HP:0002039)1.84412526
141Dysostosis multiplex (HP:0000943)1.84165260
142Loss of speech (HP:0002371)1.83879559
143Chronic sinusitis (HP:0011109)1.83812013
144Hydroxyprolinuria (HP:0003080)1.82507268
145Abnormality of proline metabolism (HP:0010907)1.82507268
146Eosinophilia (HP:0001880)1.82469230
147Periorbital edema (HP:0100539)1.80512126
148Glomerulonephritis (HP:0000099)1.79291639
149Urinary glycosaminoglycan excretion (HP:0003541)1.79287964
150Mucopolysacchariduria (HP:0008155)1.79287964
151Axonal loss (HP:0003447)1.78371741
152Facial edema (HP:0000282)1.77804469

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK43.82182844
2IRAK33.43404841
3CAMK1D3.30884625
4MAP3K143.27467743
5BLK3.21745532
6SIK33.18340124
7MAP4K13.09394879
8TBK12.58068657
9SMG12.47235379
10CAMK1G2.29004215
11KIT2.26957389
12TGFBR22.25614773
13ERN12.15130599
14CSF1R2.14376063
15TYK22.13848924
16SIK22.09793620
17TAOK22.04990851
18TNK21.87694001
19MAP3K131.71585284
20PIM21.69477822
21SIK11.63232482
22RIPK41.60642722
23TEC1.56347693
24TXK1.54528701
25IKBKB1.52290641
26SYK1.45632228
27EIF2AK21.44618594
28GRK61.43455776
29FES1.42711034
30RPS6KA41.38824395
31TRIB31.38302544
32JAK31.38255377
33IKBKE1.35778068
34NME21.35081959
35MARK21.34909922
36TTN1.34753279
37ICK1.29066112
38BTK1.28522699
39OBSCN1.27104891
40MAP3K11.20521479
41MAP2K31.19979814
42HCK1.19485970
43LYN1.18702539
44IRAK21.14988185
45ZAP701.13177269
46JAK11.11626150
47TIE11.11152337
48VRK11.06531770
49CSK1.05760738
50CLK11.02710897
51BRD41.01783682
52PIM10.99776819
53CDC42BPA0.99555804
54ABL20.99555651
55PAK40.98602440
56PRKD20.98369802
57TAOK30.97253869
58MARK30.95579300
59CAMKK20.93004465
60TESK20.90387534
61CHUK0.90071650
62YES10.89149132
63CDK190.86468398
64KSR20.86178630
65ERBB30.85192117
66RPS6KA60.83647888
67MAP3K60.81061003
68RPS6KC10.79434509
69RPS6KL10.79434509
70DYRK1B0.79333340
71PDPK10.78904770
72MAP3K100.76871729
73LRRK20.76844058
74IRAK10.76376081
75CAMK40.76134518
76PDK10.75469881
77MAPK40.74409491
78CDK90.74256166
79DAPK20.72909418
80MAP2K40.67612503
81LCK0.66201511
82FLT30.65033594
83MAP3K70.63504184
84PRPF4B0.62626387
85ARAF0.61934439
86BRAF0.61368879
87FGFR40.58713480
88MAPK110.57787935
89RIPK10.57728743
90RPS6KA20.57627072
91JAK20.53726076
92MAP3K80.53629540
93MKNK20.53509474
94MOS0.52947882
95ABL10.52578931
96CDK120.52188998
97NUAK10.51598312
98GRK70.51268481
99ATR0.51017990
100CDK40.50507667
101STK110.50157069
102BCKDK0.49864406
103MAPK70.48615839
104PRKAA20.48289777
105DYRK20.48055428
106MATK0.47530704
107SGK30.47188652
108MARK10.46870515
109PRKCQ0.46695777
110PTK60.46082081
111HIPK20.44865041
112FGFR30.43337478
113PRKCD0.42523895
114ALK0.42134233
115PIK3CG0.40621438
116STK100.38499530
117MAP2K20.37384332
118MAPK150.36794734
119EPHA30.36368503
120EPHB10.36135296
121CDK80.35922756
122DYRK30.35813381
123FYN0.35739724
124ITK0.35377958
125PRKG20.34084062
126MUSK0.33995801
127EEF2K0.33278961
128MAP3K110.33117526
129PRKCZ0.33014129
130MAPKAPK20.31669063
131MAP3K30.31668736
132TRPM70.31628034
133MAPK120.31619553
134RPS6KB10.31095798
135BMX0.30599374
136CAMK10.30569313
137CAMKK10.30368309
138PKN20.30016156
139MAPK30.28788613
140TAOK10.28151356
141FGR0.28078802
142KDR0.27202673
143MAPK130.26766794
144CDK60.25977537
145RPS6KA10.23959002

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.19808405
2Osteoclast differentiation_Homo sapiens_hsa043802.73726733
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.57915723
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.43841258
5Staphylococcus aureus infection_Homo sapiens_hsa051502.43718531
6B cell receptor signaling pathway_Homo sapiens_hsa046622.35419395
7Autoimmune thyroid disease_Homo sapiens_hsa053202.33131556
8Legionellosis_Homo sapiens_hsa051342.09240347
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.01907570
10Tuberculosis_Homo sapiens_hsa051522.00288318
11Malaria_Homo sapiens_hsa051441.97000342
12Pertussis_Homo sapiens_hsa051331.91792799
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.91323687
14Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.83534474
15Asthma_Homo sapiens_hsa053101.80518284
16TNF signaling pathway_Homo sapiens_hsa046681.74855113
17Type I diabetes mellitus_Homo sapiens_hsa049401.71053640
18Measles_Homo sapiens_hsa051621.70037631
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.64930535
20Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.60224932
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.54806395
22Toxoplasmosis_Homo sapiens_hsa051451.54693516
23Other glycan degradation_Homo sapiens_hsa005111.54557927
24Influenza A_Homo sapiens_hsa051641.53057099
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52569197
26Apoptosis_Homo sapiens_hsa042101.47595539
27Lysosome_Homo sapiens_hsa041421.45829216
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.44636472
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.43427387
30Herpes simplex infection_Homo sapiens_hsa051681.41447857
31Phagosome_Homo sapiens_hsa041451.39504651
32Hematopoietic cell lineage_Homo sapiens_hsa046401.38128014
33Shigellosis_Homo sapiens_hsa051311.37617386
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.34616875
35Chronic myeloid leukemia_Homo sapiens_hsa052201.32378491
36Base excision repair_Homo sapiens_hsa034101.32302391
37African trypanosomiasis_Homo sapiens_hsa051431.30129541
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.26584398
39Acute myeloid leukemia_Homo sapiens_hsa052211.25159259
40Salmonella infection_Homo sapiens_hsa051321.22166142
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.18971914
42Chemokine signaling pathway_Homo sapiens_hsa040621.16127090
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14180613
44Rheumatoid arthritis_Homo sapiens_hsa053231.13938618
45Hepatitis B_Homo sapiens_hsa051611.13423208
46DNA replication_Homo sapiens_hsa030301.13386278
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12648412
48Adipocytokine signaling pathway_Homo sapiens_hsa049201.10220000
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05747089
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05344340
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05138721
52Antigen processing and presentation_Homo sapiens_hsa046121.05074985
53Viral myocarditis_Homo sapiens_hsa054161.03990215
54Fatty acid biosynthesis_Homo sapiens_hsa000611.03216234
55PPAR signaling pathway_Homo sapiens_hsa033201.01209144
56Renal cell carcinoma_Homo sapiens_hsa052111.00230210
57Bladder cancer_Homo sapiens_hsa052190.98542636
58Primary immunodeficiency_Homo sapiens_hsa053400.97968823
59* Neurotrophin signaling pathway_Homo sapiens_hsa047220.91462021
60Endometrial cancer_Homo sapiens_hsa052130.91441705
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89944597
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88254111
63Pancreatic cancer_Homo sapiens_hsa052120.87823123
64Graft-versus-host disease_Homo sapiens_hsa053320.85936585
65Allograft rejection_Homo sapiens_hsa053300.84737421
66Hepatitis C_Homo sapiens_hsa051600.80465241
67Prolactin signaling pathway_Homo sapiens_hsa049170.79795959
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.76357034
69Notch signaling pathway_Homo sapiens_hsa043300.75877169
70Insulin resistance_Homo sapiens_hsa049310.75014526
71Endocytosis_Homo sapiens_hsa041440.74816688
72Epstein-Barr virus infection_Homo sapiens_hsa051690.73648264
73Systemic lupus erythematosus_Homo sapiens_hsa053220.73354351
74Pentose phosphate pathway_Homo sapiens_hsa000300.72475860
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.68311030
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67744699
77GnRH signaling pathway_Homo sapiens_hsa049120.66480294
78Small cell lung cancer_Homo sapiens_hsa052220.65387175
79Colorectal cancer_Homo sapiens_hsa052100.63438976
80T cell receptor signaling pathway_Homo sapiens_hsa046600.62853668
81FoxO signaling pathway_Homo sapiens_hsa040680.61400488
82HIF-1 signaling pathway_Homo sapiens_hsa040660.61352562
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61230697
84HTLV-I infection_Homo sapiens_hsa051660.61209155
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60603191
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59789283
87Platelet activation_Homo sapiens_hsa046110.59389933
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58695432
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.58185773
90Propanoate metabolism_Homo sapiens_hsa006400.57058496
91Glioma_Homo sapiens_hsa052140.57055920
92ErbB signaling pathway_Homo sapiens_hsa040120.55563661
93MicroRNAs in cancer_Homo sapiens_hsa052060.55182548
94Type II diabetes mellitus_Homo sapiens_hsa049300.55064736
95Mismatch repair_Homo sapiens_hsa034300.54777940
96mTOR signaling pathway_Homo sapiens_hsa041500.52930983
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52462157
98Homologous recombination_Homo sapiens_hsa034400.52315649
99Amoebiasis_Homo sapiens_hsa051460.51314410
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48169526
101Fatty acid metabolism_Homo sapiens_hsa012120.48123986
102AMPK signaling pathway_Homo sapiens_hsa041520.47075932
103Choline metabolism in cancer_Homo sapiens_hsa052310.45896319
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.45773513
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45402465
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45389796
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44473345
108Prostate cancer_Homo sapiens_hsa052150.43886317
109Fructose and mannose metabolism_Homo sapiens_hsa000510.42473372
110Viral carcinogenesis_Homo sapiens_hsa052030.42230957
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.42166368
112Pathways in cancer_Homo sapiens_hsa052000.40666085
113Inositol phosphate metabolism_Homo sapiens_hsa005620.38016920
114Olfactory transduction_Homo sapiens_hsa047400.36875286
115MAPK signaling pathway_Homo sapiens_hsa040100.35602022
116p53 signaling pathway_Homo sapiens_hsa041150.35513409
117Lysine degradation_Homo sapiens_hsa003100.34921476
118Melanoma_Homo sapiens_hsa052180.34512141
119VEGF signaling pathway_Homo sapiens_hsa043700.33304996
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32699701
121* Insulin signaling pathway_Homo sapiens_hsa049100.32663592
122Glycerolipid metabolism_Homo sapiens_hsa005610.32413234
123Non-small cell lung cancer_Homo sapiens_hsa052230.32019923

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