SH2D1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)6.39094282
2negative regulation of cell killing (GO:0031342)6.35622404
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.35622404
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.04179831
5positive T cell selection (GO:0043368)6.01998200
6regulation of isotype switching to IgG isotypes (GO:0048302)5.93786799
7negative thymic T cell selection (GO:0045060)5.78061261
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.73261445
9activated T cell proliferation (GO:0050798)5.55682269
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.51402102
11cytidine metabolic process (GO:0046087)5.47009770
12cytidine catabolic process (GO:0006216)5.47009770
13cytidine deamination (GO:0009972)5.47009770
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.23693203
15cellular response to interleukin-15 (GO:0071350)5.23033663
16pyrimidine ribonucleoside catabolic process (GO:0046133)5.13245743
17antigen processing and presentation of endogenous antigen (GO:0019883)5.12174605
18positive regulation of gamma-delta T cell activation (GO:0046645)5.02205843
19T cell selection (GO:0045058)4.97830126
20Arp2/3 complex-mediated actin nucleation (GO:0034314)4.88498869
21interferon-gamma production (GO:0032609)4.88433617
22DNA deamination (GO:0045006)4.81400235
23neuron cell-cell adhesion (GO:0007158)4.77027643
24positive thymic T cell selection (GO:0045059)4.75525233
25response to interleukin-15 (GO:0070672)4.69875949
26thymic T cell selection (GO:0045061)4.58643237
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.57667786
28positive regulation of tolerance induction (GO:0002645)4.53948852
29presynaptic membrane assembly (GO:0097105)4.46199028
30T cell migration (GO:0072678)4.45673433
31positive regulation of B cell differentiation (GO:0045579)4.43592318
32positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.42173464
33antigen processing and presentation via MHC class Ib (GO:0002475)4.31706876
34T cell receptor signaling pathway (GO:0050852)4.29514205
35presynaptic membrane organization (GO:0097090)4.25407031
36positive regulation of granulocyte differentiation (GO:0030854)4.23948953
37regulation of B cell differentiation (GO:0045577)4.23741470
38Peyers patch development (GO:0048541)4.19847442
39mucosal-associated lymphoid tissue development (GO:0048537)4.19847442
40* positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.18820091
41actin nucleation (GO:0045010)4.06620925
42regulation of tolerance induction (GO:0002643)3.99382916
43leukocyte aggregation (GO:0070486)3.97033843
44* regulation of leukocyte mediated cytotoxicity (GO:0001910)3.93839895
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.90953026
46T cell costimulation (GO:0031295)3.82233411
47positive regulation of T cell mediated cytotoxicity (GO:0001916)3.82095935
48lymphocyte costimulation (GO:0031294)3.81141008
49* positive regulation of cell killing (GO:0031343)3.80205569
50negative regulation of synaptic transmission, GABAergic (GO:0032229)3.78721384
51gamma-aminobutyric acid signaling pathway (GO:0007214)3.74208230
52regulation of gamma-delta T cell differentiation (GO:0045586)3.72418547
53vocalization behavior (GO:0071625)3.70389562
54negative regulation of T cell apoptotic process (GO:0070233)3.69327572
55ionotropic glutamate receptor signaling pathway (GO:0035235)3.68709472
56regulation of T cell mediated cytotoxicity (GO:0001914)3.68631890
57negative regulation of T cell mediated immunity (GO:0002710)3.61887479
58* regulation of cell killing (GO:0031341)3.57804674
59glutamate receptor signaling pathway (GO:0007215)3.55439381
60startle response (GO:0001964)3.47871579
61regulation of gamma-delta T cell activation (GO:0046643)3.47867830
62antigen receptor-mediated signaling pathway (GO:0050851)3.47445789
63regulation of B cell receptor signaling pathway (GO:0050855)3.45217030
64regulation of T cell tolerance induction (GO:0002664)3.43799755
65positive regulation of alpha-beta T cell proliferation (GO:0046641)3.43295867
66mast cell activation (GO:0045576)3.43014325
67response to histamine (GO:0034776)3.42947369
68protein localization to synapse (GO:0035418)3.40022028
69regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.39336204
70regulation of regulatory T cell differentiation (GO:0045589)3.37120272
71regulation of interleukin-2 biosynthetic process (GO:0045076)3.35638492
72dopamine transport (GO:0015872)3.27167072
73regulation of glutamate receptor signaling pathway (GO:1900449)3.27128308
74positive regulation of uterine smooth muscle contraction (GO:0070474)3.24821103
75negative regulation of viral genome replication (GO:0045071)3.23992498
76regulation of short-term neuronal synaptic plasticity (GO:0048172)3.23419784
77positive regulation of interleukin-4 production (GO:0032753)3.22908622
78positive regulation of humoral immune response (GO:0002922)3.21825264
79positive regulation of synapse assembly (GO:0051965)3.20132795
80NIK/NF-kappaB signaling (GO:0038061)3.19613495
81regulation of T cell chemotaxis (GO:0010819)3.19176006
82positive regulation of T cell chemotaxis (GO:0010820)3.19176006
83regulation of isotype switching (GO:0045191)3.18248809
84negative regulation of lymphocyte mediated immunity (GO:0002707)3.17337623
85regulation of T cell receptor signaling pathway (GO:0050856)3.17053626
86neuron-neuron synaptic transmission (GO:0007270)3.15614158
87T cell activation (GO:0042110)3.15364309
88negative regulation of type 2 immune response (GO:0002829)3.14871270
89postsynaptic membrane organization (GO:0001941)3.11865595
90regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.10043655
91* positive regulation of lymphocyte mediated immunity (GO:0002708)3.08986440
92alpha-beta T cell differentiation (GO:0046632)3.08923694
93regulation of alpha-beta T cell proliferation (GO:0046640)3.07432030
94cytolysis (GO:0019835)3.06241964
95cellular response to type I interferon (GO:0071357)3.06237804
96type I interferon signaling pathway (GO:0060337)3.06237804
97regulation of lymphocyte chemotaxis (GO:1901623)3.06145109
98T cell homeostasis (GO:0043029)3.04184464
99neuron recognition (GO:0008038)3.03858875
100response to type I interferon (GO:0034340)3.02797537
101natural killer cell differentiation (GO:0001779)3.01499555
102lymphocyte chemotaxis (GO:0048247)3.00698075
103B cell receptor signaling pathway (GO:0050853)2.99900854
104regulation of alpha-beta T cell activation (GO:0046634)2.98712743
105positive regulation of DNA recombination (GO:0045911)2.98648386
106regulation of glutamate secretion (GO:0014048)2.97262287
107dendritic cell chemotaxis (GO:0002407)2.97198301
108regulation of granulocyte differentiation (GO:0030852)2.96557897
109regulation of chronic inflammatory response (GO:0002676)2.96335592
110positive regulation of calcium-mediated signaling (GO:0050850)2.96290266
111natural killer cell activation (GO:0030101)2.95513311
112regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.95356550
113positive regulation of T cell mediated immunity (GO:0002711)2.95153792
114positive regulation of alpha-beta T cell activation (GO:0046635)2.94941558
115opioid receptor signaling pathway (GO:0038003)2.91969414
116regulation of defense response to virus by virus (GO:0050690)2.90590163
117glycosphingolipid biosynthetic process (GO:0006688)2.89436796
118alpha-beta T cell activation (GO:0046631)2.87346244
119synaptic transmission, glutamatergic (GO:0035249)2.86511999
120V(D)J recombination (GO:0033151)2.85623985
121regulation of uterine smooth muscle contraction (GO:0070472)2.85282929
122positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.84833283
123* positive regulation of natural killer cell mediated immunity (GO:0002717)2.84373914
124* positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.84373914
125synaptic transmission, dopaminergic (GO:0001963)2.83969560
126G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.81761167
127T cell differentiation (GO:0030217)2.81506837
128synaptic vesicle exocytosis (GO:0016079)2.80295634
129catecholamine transport (GO:0051937)2.80276489
130positive regulation of isotype switching (GO:0045830)2.79825059
131transmission of nerve impulse (GO:0019226)2.78155363
132negative regulation of neurotransmitter transport (GO:0051589)2.77769715
133serotonin receptor signaling pathway (GO:0007210)2.75683608
134* regulation of natural killer cell mediated immunity (GO:0002715)2.74887885
135* regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.74887885
136positive regulation of interleukin-2 production (GO:0032743)2.74417387
137neurotransmitter-gated ion channel clustering (GO:0072578)2.72713373
138mast cell activation involved in immune response (GO:0002279)2.72274124
139mast cell degranulation (GO:0043303)2.72274124
140behavioral defense response (GO:0002209)2.68508328
141behavioral fear response (GO:0001662)2.68508328
142regulation of immunoglobulin mediated immune response (GO:0002889)2.66150117
143tolerance induction (GO:0002507)2.66132956
144lymphocyte migration (GO:0072676)2.65302071
145negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.63440782
146sequestering of actin monomers (GO:0042989)2.63008708
147negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.62572284
148negative regulation of T cell receptor signaling pathway (GO:0050860)2.58858930
149regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.58115014
150long-term memory (GO:0007616)2.56114330
151negative regulation of B cell mediated immunity (GO:0002713)2.56027636

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.21660989
2EZH2_22144423_ChIP-Seq_EOC_Human4.99385645
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.63383048
4GBX2_23144817_ChIP-Seq_PC3_Human3.86609169
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.44288340
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.43160689
7TAF15_26573619_Chip-Seq_HEK293_Human3.28325408
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.15047323
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.89281458
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.79177322
11MYB_26560356_Chip-Seq_TH1_Human2.77562543
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.74460897
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.73701069
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.70394079
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.69382882
16MAF_26560356_Chip-Seq_TH1_Human2.56699560
17* GATA3_27048872_Chip-Seq_THYMUS_Human2.54903765
18* UTX_26944678_Chip-Seq_JUKART_Human2.44043002
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.38116677
20JARID2_20064375_ChIP-Seq_MESCs_Mouse2.29069718
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.24080035
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.23647645
23NOTCH1_21737748_ChIP-Seq_TLL_Human2.14106709
24AR_21572438_ChIP-Seq_LNCaP_Human2.13377104
25POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12408645
26MAF_26560356_Chip-Seq_TH2_Human2.12301436
27CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07475658
28SPI1_23547873_ChIP-Seq_NB4_Human2.07184618
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.06919984
30GATA3_26560356_Chip-Seq_TH2_Human2.05987675
31* RUNX_20019798_ChIP-Seq_JUKART_Human2.03056906
32CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03028525
33PCGF2_27294783_Chip-Seq_ESCs_Mouse2.02737437
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.01160424
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.99826964
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.99584002
37* P300_19829295_ChIP-Seq_ESCs_Human1.98680858
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.98302450
39REST_21632747_ChIP-Seq_MESCs_Mouse1.97896950
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96665135
41E2F7_22180533_ChIP-Seq_HELA_Human1.87123835
42IRF8_27001747_Chip-Seq_BMDM_Mouse1.86970774
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.86856740
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.83315914
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80563096
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.79745719
47FUS_26573619_Chip-Seq_HEK293_Human1.76479028
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.76045223
49SMAD4_21799915_ChIP-Seq_A2780_Human1.75540090
50VDR_22108803_ChIP-Seq_LS180_Human1.74955084
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.73305011
52SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72315786
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71159110
54SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69025427
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.68328587
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67880451
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.65392104
58STAT4_19710469_ChIP-ChIP_TH1__Mouse1.63475174
59MYC_22102868_ChIP-Seq_BL_Human1.62618428
60EZH2_27304074_Chip-Seq_ESCs_Mouse1.61076494
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60081529
62CIITA_25753668_ChIP-Seq_RAJI_Human1.58508698
63JARID2_20075857_ChIP-Seq_MESCs_Mouse1.57315029
64VDR_23849224_ChIP-Seq_CD4+_Human1.56661493
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.56632636
66RNF2_18974828_ChIP-Seq_MESCs_Mouse1.54907765
67EZH2_18974828_ChIP-Seq_MESCs_Mouse1.54907765
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54744207
69FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.53669188
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.53128237
71IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52911314
72BP1_19119308_ChIP-ChIP_Hs578T_Human1.52650928
73SCL_19346495_ChIP-Seq_HPC-7_Human1.52078043
74RUNX1_22412390_ChIP-Seq_EML_Mouse1.49911908
75SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.48179235
76IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.47384262
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46839486
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46594780
79MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46492817
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45916228
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.45352610
82MTF2_20144788_ChIP-Seq_MESCs_Mouse1.44547301
83EED_16625203_ChIP-ChIP_MESCs_Mouse1.44515945
84MYB_21317192_ChIP-Seq_ERMYB_Mouse1.44028079
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43133040
86NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43072399
87NFE2_27457419_Chip-Seq_LIVER_Mouse1.41877240
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40784765
89REST_18959480_ChIP-ChIP_MESCs_Mouse1.40394878
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40284105
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.39550609
92IGF1R_20145208_ChIP-Seq_DFB_Human1.38289347
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37434934
94SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35042189
95* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.33477351
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33354208
97ER_23166858_ChIP-Seq_MCF-7_Human1.32841527
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.32381518
99CMYC_18555785_Chip-Seq_ESCs_Mouse1.31952382
100RNF2_27304074_Chip-Seq_NSC_Mouse1.31795734
101P53_22387025_ChIP-Seq_ESCs_Mouse1.31312835
102E2F1_18555785_Chip-Seq_ESCs_Mouse1.30526722
103* FOXP3_21729870_ChIP-Seq_TREG_Human1.30097318
104EZH2_27294783_Chip-Seq_NPCs_Mouse1.29722886
105LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28700203
106SPI1_23127762_ChIP-Seq_K562_Human1.28222561
107HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27325618
108EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.27132345
109SUZ12_18555785_Chip-Seq_ESCs_Mouse1.26769679
110RNF2_27304074_Chip-Seq_ESCs_Mouse1.25544351
111VDR_24763502_ChIP-Seq_THP-1_Human1.24948080
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24130904
113EZH2_27294783_Chip-Seq_ESCs_Mouse1.23758370
114AR_25329375_ChIP-Seq_VCAP_Human1.23207630
115P300_18555785_Chip-Seq_ESCs_Mouse1.22744928
116SMAD3_21741376_ChIP-Seq_EPCs_Human1.22571467
117* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.21191315
118NMYC_18555785_Chip-Seq_ESCs_Mouse1.20985537
119TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20209093
120CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19564827
121DROSHA_22980978_ChIP-Seq_HELA_Human1.18701745
122NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18530918
123SOX2_18555785_Chip-Seq_ESCs_Mouse1.17693099
124STAT3_18555785_Chip-Seq_ESCs_Mouse1.17151229
125EWS_26573619_Chip-Seq_HEK293_Human1.16004688
126PIAS1_25552417_ChIP-Seq_VCAP_Human1.13888848
127RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.13166139
128JUN_21703547_ChIP-Seq_K562_Human1.12839087
129SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12452161
130RUNX1_27457419_Chip-Seq_LIVER_Mouse1.11541909
131* MYB_26560356_Chip-Seq_TH2_Human1.11251367
132STAT3_23295773_ChIP-Seq_U87_Human1.09932194
133GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09806103
134OCT4_18555785_Chip-Seq_ESCs_Mouse1.09637446
135ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07591745
136TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06657964
137POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06657964
138IRF1_19129219_ChIP-ChIP_H3396_Human1.05894925
139HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05193832
140SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04945835
141ZNF274_21170338_ChIP-Seq_K562_Hela1.04417253
142ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04387177
143TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04165156
144CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03969404
145* KDM2B_26808549_Chip-Seq_REH_Human1.03925481
146RARB_27405468_Chip-Seq_BRAIN_Mouse1.03684150
147GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01409732
148KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99689622
149EST1_17652178_ChIP-ChIP_JURKAT_Human0.99212441
150GABP_17652178_ChIP-ChIP_JURKAT_Human0.98878018
151VDR_21846776_ChIP-Seq_THP-1_Human0.97311674
152GATA3_26560356_Chip-Seq_TH1_Human0.95749508
153FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93903718
154EGR1_19374776_ChIP-ChIP_THP-1_Human0.93113350
155VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91841774
156CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90961821
157CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87300931
158CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84434674
159RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.81909161
160BCL6_27268052_Chip-Seq_Bcells_Human0.80720810
161TCF7_22412390_ChIP-Seq_EML_Mouse0.80585235
162E2F4_17652178_ChIP-ChIP_JURKAT_Human0.78837255
163CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.77896757
164PU_27001747_Chip-Seq_BMDM_Mouse0.76669398
165RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.76152931
166KDM2B_26808549_Chip-Seq_DND41_Human0.75275590
167PU.1_20513432_ChIP-Seq_Bcells_Mouse0.75256513
168GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75215952
169PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70244714
170EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.70112089
171PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.69772163
172TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.69575373
173VDR_24787735_ChIP-Seq_THP-1_Human0.69126472
174TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.67380239
175SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.66155191
176CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.65595400
177P300_27268052_Chip-Seq_Bcells_Human0.64555894
178GATA1_19941827_ChIP-Seq_MEL_Mouse0.64355855
179PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.63901421
180CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.63826511
181SMRT_27268052_Chip-Seq_Bcells_Human0.63315834
182SPI1_20517297_ChIP-Seq_HL60_Human0.62435878
183STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.62297594

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.57835829
2MP0003763_abnormal_thymus_physiology3.71672176
3MP0005671_abnormal_response_to3.41181434
4MP0003436_decreased_susceptibility_to3.03580882
5MP0009745_abnormal_behavioral_response2.96066797
6MP0003635_abnormal_synaptic_transmissio2.88659920
7MP0004859_abnormal_synaptic_plasticity2.79530870
8MP0006276_abnormal_autonomic_nervous2.77245310
9MP0001968_abnormal_touch/_nociception2.67499676
10MP0001529_abnormal_vocalization2.55660822
11MP0002064_seizures2.54503412
12MP0002736_abnormal_nociception_after2.47945088
13MP0001501_abnormal_sleep_pattern2.37264528
14MP0002572_abnormal_emotion/affect_behav2.32558135
15MP0002063_abnormal_learning/memory/cond2.31268195
16MP0009046_muscle_twitch2.24860646
17MP0002735_abnormal_chemical_nociception2.24794586
18MP0010155_abnormal_intestine_physiology2.07280761
19MP0001440_abnormal_grooming_behavior2.03378947
20MP0002272_abnormal_nervous_system2.02774254
21MP0001188_hyperpigmentation1.91772646
22MP0006082_CNS_inflammation1.90076834
23MP0004947_skin_inflammation1.88398530
24MP0001905_abnormal_dopamine_level1.88168497
25MP0002822_catalepsy1.82069599
26MP0002067_abnormal_sensory_capabilities1.79107742
27* MP0001845_abnormal_inflammatory_respons1.74336451
28MP0000685_abnormal_immune_system1.70075569
29MP0009785_altered_susceptibility_to1.69676218
30MP0001835_abnormal_antigen_presentation1.67970078
31MP0004924_abnormal_behavior1.66705401
32MP0005386_behavior/neurological_phenoty1.66705401
33MP0004142_abnormal_muscle_tone1.66079272
34MP0005423_abnormal_somatic_nervous1.65576888
35MP0001486_abnormal_startle_reflex1.65544974
36MP0005464_abnormal_platelet_physiology1.64447057
37MP0005000_abnormal_immune_tolerance1.61758598
38MP0003724_increased_susceptibility_to1.61130968
39MP0000703_abnormal_thymus_morphology1.60774935
40MP0002184_abnormal_innervation1.57896379
41MP0003300_gastrointestinal_ulcer1.56837031
42* MP0001800_abnormal_humoral_immune1.56068575
43* MP0002420_abnormal_adaptive_immunity1.55580161
44MP0001970_abnormal_pain_threshold1.54916088
45* MP0001819_abnormal_immune_cell1.52484895
46MP0002733_abnormal_thermal_nociception1.49703280
47MP0008569_lethality_at_weaning1.48947529
48MP0002557_abnormal_social/conspecific_i1.46633309
49MP0002166_altered_tumor_susceptibility1.46253199
50MP0009333_abnormal_splenocyte_physiolog1.46194944
51MP0003787_abnormal_imprinting1.45978602
52* MP0002723_abnormal_immune_serum1.44980223
53MP0001984_abnormal_olfaction1.44836236
54MP0005645_abnormal_hypothalamus_physiol1.43741702
55MP0005075_abnormal_melanosome_morpholog1.43459304
56MP0002876_abnormal_thyroid_physiology1.43367034
57MP0005409_darkened_coat_color1.42916994
58MP0002396_abnormal_hematopoietic_system1.42567738
59* MP0001790_abnormal_immune_system1.41217796
60* MP0005387_immune_system_phenotype1.41217796
61* MP0002398_abnormal_bone_marrow1.37376227
62MP0002006_tumorigenesis1.32098251
63MP0002734_abnormal_mechanical_nocicepti1.31205450
64MP0004381_abnormal_hair_follicle1.29746213
65MP0003045_fibrosis1.29402185
66MP0001853_heart_inflammation1.26083615
67MP0003122_maternal_imprinting1.25699696
68MP0003448_altered_tumor_morphology1.23730654
69* MP0000716_abnormal_immune_system1.23366351
70MP0008469_abnormal_protein_level1.23167631
71MP0005551_abnormal_eye_electrophysiolog1.22766617
72MP0001533_abnormal_skeleton_physiology1.21283280
73MP0005310_abnormal_salivary_gland1.21191564
74MP0004510_myositis1.19907147
75MP0004742_abnormal_vestibular_system1.19818902
76MP0006292_abnormal_olfactory_placode1.19669326
77MP0002138_abnormal_hepatobiliary_system1.16744462
78* MP0002452_abnormal_antigen_presenting1.14816837
79* MP0005025_abnormal_response_to1.13520595
80MP0000858_altered_metastatic_potential1.12166081
81MP0002163_abnormal_gland_morphology1.11582741
82MP0002405_respiratory_system_inflammati1.09640441
83MP0003329_amyloid_beta_deposits1.08331819
84MP0002722_abnormal_immune_system1.06494709
85MP0003866_abnormal_defecation1.06426020
86MP0009764_decreased_sensitivity_to1.05369805
87MP0008872_abnormal_physiological_respon1.05050110
88MP0002277_abnormal_respiratory_mucosa1.04091207
89MP0002148_abnormal_hypersensitivity_rea1.02229357
90MP0002638_abnormal_pupillary_reflex1.01851467
91MP0000778_abnormal_nervous_system1.01695443
92MP0002933_joint_inflammation0.99324248
93MP0004270_analgesia0.98518296
94MP0000015_abnormal_ear_pigmentation0.98408358
95MP0002009_preneoplasia0.97972230
96MP0001502_abnormal_circadian_rhythm0.96574885
97MP0000465_gastrointestinal_hemorrhage0.96370540
98MP0006072_abnormal_retinal_apoptosis0.93120614
99MP0002019_abnormal_tumor_incidence0.93074808
100MP0009763_increased_sensitivity_to0.90489937
101MP0002066_abnormal_motor_capabilities/c0.90479005
102* MP0000689_abnormal_spleen_morphology0.90471583
103MP0001348_abnormal_lacrimal_gland0.89393238
104MP0005379_endocrine/exocrine_gland_phen0.88806054
105MP0003786_premature_aging0.85912796
106MP0005646_abnormal_pituitary_gland0.84501340
107MP0005535_abnormal_body_temperature0.82480760
108* MP0002429_abnormal_blood_cell0.82296217
109MP0002882_abnormal_neuron_morphology0.81425740
110MP0003633_abnormal_nervous_system0.80168150
111MP0002693_abnormal_pancreas_physiology0.79956515
112MP0002837_dystrophic_cardiac_calcinosis0.79549684
113MP0000490_abnormal_crypts_of0.77814960
114MP0003303_peritoneal_inflammation0.76693373
115MP0001873_stomach_inflammation0.76543564
116MP0008057_abnormal_DNA_replication0.75529298
117MP0005451_abnormal_body_composition0.75051048
118MP0002132_abnormal_respiratory_system0.74374465
119MP0001851_eye_inflammation0.72525420
120MP0003136_yellow_coat_color0.72473205
121MP0004811_abnormal_neuron_physiology0.71214396
122MP0002419_abnormal_innate_immunity0.70209431
123MP0002102_abnormal_ear_morphology0.70031654
124MP0005253_abnormal_eye_physiology0.69875391
125MP0001986_abnormal_taste_sensitivity0.69607490
126MP0008874_decreased_physiological_sensi0.69449367
127MP0003879_abnormal_hair_cell0.69426693
128MP0002909_abnormal_adrenal_gland0.69277785
129MP0001663_abnormal_digestive_system0.69069627
130MP0001963_abnormal_hearing_physiology0.68811658
131MP0001919_abnormal_reproductive_system0.68704674
132MP0005166_decreased_susceptibility_to0.65013931
133MP0002998_abnormal_bone_remodeling0.64263158
134MP0003252_abnormal_bile_duct0.63058244
135MP0000604_amyloidosis0.59978919
136MP0009765_abnormal_xenobiotic_induced0.59397063
137MP0000569_abnormal_digit_pigmentation0.57013676
138MP0004808_abnormal_hematopoietic_stem0.53384251
139MP0008961_abnormal_basal_metabolism0.53079549
140MP0008873_increased_physiological_sensi0.52959997
141MP0001765_abnormal_ion_homeostasis0.51542517
142MP0005377_hearing/vestibular/ear_phenot0.48177848
143MP0003878_abnormal_ear_physiology0.48177848
144MP0002136_abnormal_kidney_physiology0.47438439
145MP0003183_abnormal_peptide_metabolism0.45043704
146MP0008260_abnormal_autophagy0.42993296
147MP0003795_abnormal_bone_structure0.41376826
148MP0008877_abnormal_DNA_methylation0.40368036
149MP0010307_abnormal_tumor_latency0.39935954
150MP0000249_abnormal_blood_vessel0.37327375
151MP0009643_abnormal_urine_homeostasis0.37278019
152MP0000609_abnormal_liver_physiology0.36757648
153MP0002083_premature_death0.36400909
154MP0001191_abnormal_skin_condition0.36138435
155MP0003806_abnormal_nucleotide_metabolis0.36097244
156MP0003172_abnormal_lysosome_physiology0.35039033
157MP0000920_abnormal_myelination0.34977706
158MP0004883_abnormal_blood_vessel0.34392792

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.84148073
2Abnormality of T cell number (HP:0011839)5.70640558
3Focal motor seizures (HP:0011153)5.57815434
4Severe combined immunodeficiency (HP:0004430)5.29064178
5Combined immunodeficiency (HP:0005387)4.54624666
6Panhypogammaglobulinemia (HP:0003139)4.21535598
7Atonic seizures (HP:0010819)4.16894311
8Febrile seizures (HP:0002373)3.98279368
9Thyroiditis (HP:0100646)3.73971004
10Hyperventilation (HP:0002883)3.69789040
11Stomatitis (HP:0010280)3.68070867
12Abnormal hair whorl (HP:0010721)3.63751513
13Abnormality of T cells (HP:0002843)3.59537222
14* Encephalitis (HP:0002383)3.59261618
15Aplastic anemia (HP:0001915)3.57415755
16Autoimmune thrombocytopenia (HP:0001973)3.56538716
17B lymphocytopenia (HP:0010976)3.55791174
18Abnormality of B cell number (HP:0010975)3.55791174
19Abnormality of T cell physiology (HP:0011840)3.35904196
20Focal seizures (HP:0007359)3.32722961
21Abnormality of macrophages (HP:0004311)3.32130205
22Epileptic encephalopathy (HP:0200134)3.29458482
23Abnormality of binocular vision (HP:0011514)3.28206797
24Diplopia (HP:0000651)3.28206797
25Abnormality of eosinophils (HP:0001879)3.15021515
26Pulmonary infiltrates (HP:0002113)3.13369571
27Recurrent bacterial skin infections (HP:0005406)3.04712882
28Vasculitis (HP:0002633)3.04280361
29Hypoplasia of the thymus (HP:0000778)3.03815959
30Chronic mucocutaneous candidiasis (HP:0002728)3.03441751
31Recurrent cutaneous fungal infections (HP:0011370)3.03441751
32Recurrent abscess formation (HP:0002722)3.03260987
33Mediastinal lymphadenopathy (HP:0100721)3.02242286
34Progressive inability to walk (HP:0002505)3.01982656
35Recurrent skin infections (HP:0001581)3.01876528
36Absence seizures (HP:0002121)2.93926766
37* IgG deficiency (HP:0004315)2.92430198
38Recurrent fungal infections (HP:0002841)2.91430347
39Eosinophilia (HP:0001880)2.86630858
40Pustule (HP:0200039)2.85541478
41Acute necrotizing encephalopathy (HP:0006965)2.85139522
42Increased IgE level (HP:0003212)2.79938045
43Elevated erythrocyte sedimentation rate (HP:0003565)2.79350955
44Spontaneous hematomas (HP:0007420)2.78681637
45Dialeptic seizures (HP:0011146)2.71368377
46Limb dystonia (HP:0002451)2.67248315
47Agammaglobulinemia (HP:0004432)2.67155528
48Abnormality of the prostate (HP:0008775)2.66361231
49Visual hallucinations (HP:0002367)2.63859488
50Recurrent bronchitis (HP:0002837)2.63797351
51Progressive macrocephaly (HP:0004481)2.63181219
52Autoimmune hemolytic anemia (HP:0001890)2.62001121
53Abnormal mitochondria in muscle tissue (HP:0008316)2.60591097
54Retrobulbar optic neuritis (HP:0100654)2.59817418
55Optic neuritis (HP:0100653)2.59817418
56Myositis (HP:0100614)2.59163492
57Chest pain (HP:0100749)2.56455533
58Inability to walk (HP:0002540)2.55937429
59Joint swelling (HP:0001386)2.55893769
60Progressive cerebellar ataxia (HP:0002073)2.55018380
61* Lymphoma (HP:0002665)2.53227024
62Recurrent viral infections (HP:0004429)2.46398821
63* Hypergammaglobulinemia (HP:0010702)2.45113599
64Medial flaring of the eyebrow (HP:0010747)2.44087711
65Gait imbalance (HP:0002141)2.42770013
66Absent/shortened dynein arms (HP:0200106)2.42702767
67Dynein arm defect of respiratory motile cilia (HP:0012255)2.42702767
68Broad-based gait (HP:0002136)2.42283567
69Gangrene (HP:0100758)2.42129253
70IgA deficiency (HP:0002720)2.40090583
71Obstructive lung disease (HP:0006536)2.39964705
72Chronic obstructive pulmonary disease (HP:0006510)2.39964705
73Pulmonary embolism (HP:0002204)2.36986239
74Nasal polyposis (HP:0100582)2.36637800
75Abnormal ciliary motility (HP:0012262)2.34429184
76Mitochondrial inheritance (HP:0001427)2.34184990
77Recurrent sinusitis (HP:0011108)2.34106021
78Bronchitis (HP:0012387)2.33830151
79Optic disc pallor (HP:0000543)2.32981853
80Fair hair (HP:0002286)2.28877909
81Generalized tonic-clonic seizures (HP:0002069)2.28442321
82Chronic sinusitis (HP:0011109)2.27931431
83Abnormal delayed hypersensitivity skin test (HP:0002963)2.27920030
84Aplasia/Hypoplasia of the thymus (HP:0010515)2.25666337
85Papilledema (HP:0001085)2.24640781
86Leukocytosis (HP:0001974)2.24516325
87Congenital primary aphakia (HP:0007707)2.23680970
88Granulocytopenia (HP:0001913)2.22359766
89Keratoconjunctivitis sicca (HP:0001097)2.21284162
90Abnormality of the fingertips (HP:0001211)2.19724289
91Arterial thrombosis (HP:0004420)2.13450314
92Protruding tongue (HP:0010808)2.13216874
93Hypoproteinemia (HP:0003075)2.12691375
94Epistaxis (HP:0000421)2.12574273
95Amyotrophic lateral sclerosis (HP:0007354)2.12125724
96Skin rash (HP:0000988)2.11050005
97Drooling (HP:0002307)2.10017459
98Excessive salivation (HP:0003781)2.10017459
99Hemiplegia (HP:0002301)2.09781822
100Eczematoid dermatitis (HP:0000976)2.07779681
101Keratoconjunctivitis (HP:0001096)2.06978994
102Lymphopenia (HP:0001888)2.06541413
103Nephrogenic diabetes insipidus (HP:0009806)2.05938812
104Esotropia (HP:0000565)2.05669877
105Fatigue (HP:0012378)2.04920920
106Slow saccadic eye movements (HP:0000514)2.02824918
107IgM deficiency (HP:0002850)2.02619461
108Chronic diarrhea (HP:0002028)2.02365935
109Abnormality of the pleura (HP:0002103)2.01808977
110Keratitis (HP:0000491)2.00524814
111Truncal ataxia (HP:0002078)1.99945162
112Chronic otitis media (HP:0000389)1.99027482
113Prolonged bleeding time (HP:0003010)1.98891471
114* Increased IgM level (HP:0003496)1.98731058
115Verrucae (HP:0200043)1.97214346
116Papilloma (HP:0012740)1.97214346
117Poor suck (HP:0002033)1.95262069
118Absent speech (HP:0001344)1.94091161
119Generalized hypopigmentation of hair (HP:0011358)1.93702125
120Abnormal respiratory motile cilium physiology (HP:0012261)1.93281189
121Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.92974558
122Microcytic anemia (HP:0001935)1.92798871
123Abnormality of cells of the lymphoid lineage (HP:0012140)1.92783298
124Myokymia (HP:0002411)1.92605886
125Hypochromic anemia (HP:0001931)1.92562200
126Anorexia (HP:0002039)1.92475522
127Abnormal respiratory epithelium morphology (HP:0012253)1.91895778
128Abnormal respiratory motile cilium morphology (HP:0005938)1.91895778
129* Meningitis (HP:0001287)1.91626733
130Inflammation of the large intestine (HP:0002037)1.90460300
131Acute encephalopathy (HP:0006846)1.87658961
132Increased CSF lactate (HP:0002490)1.85197835
133Absent rod-and cone-mediated responses on ERG (HP:0007688)1.83017255
1343-Methylglutaconic aciduria (HP:0003535)1.82511533
135Basal ganglia calcification (HP:0002135)1.81455195
136Hypothermia (HP:0002045)1.80770484
137Hemoptysis (HP:0002105)1.80542152
138Bronchiectasis (HP:0002110)1.79927791
139Petechiae (HP:0000967)1.78801092
140Amblyopia (HP:0000646)1.78085472
141Gastrointestinal inflammation (HP:0004386)1.78040335
142Alveolar cell carcinoma (HP:0006519)1.75318463
143Amaurosis fugax (HP:0100576)1.74847837
144Orchitis (HP:0100796)1.73800566
145Gastrointestinal infarctions (HP:0005244)1.73667412
146Urticaria (HP:0001025)1.72906305
147Polyphagia (HP:0002591)1.72621912
148Hepatocellular necrosis (HP:0001404)1.71818394
149Glomerulopathy (HP:0100820)1.67987364
150Neutropenia (HP:0001875)1.67967381
151Recurrent otitis media (HP:0000403)1.65523305
152Renal cortical cysts (HP:0000803)1.64834607

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.71218191
2MAP3K124.25378076
3CASK3.69172602
4MAP4K12.83970768
5NTRK32.70622119
6TESK22.69754898
7PNCK2.36889850
8MAP2K72.34243150
9RIPK42.32322285
10TAOK32.12125167
11SIK22.10413857
12BTK2.07511273
13GRK62.06667640
14ZAP701.97174844
15FES1.89960028
16TNIK1.86778488
17ITK1.85984251
18GRK71.85663890
19ADRBK21.81054705
20PRPF4B1.75419962
21STK101.70184620
22SCYL21.69905567
23MAP3K41.64402892
24CAMKK21.61725538
25MARK31.60795632
26MST41.57252758
27JAK31.51480833
28LCK1.49742303
29TNK21.48097277
30EPHA41.46734313
31SIK31.45423813
32MAP3K131.45418777
33NTRK21.37351302
34TLK11.34661777
35NME11.33230916
36SYK1.32789939
37BMPR21.32486224
38MINK11.26082961
39MAP3K141.22001388
40IKBKE1.21729844
41PLK21.21161829
42MAP3K111.20924039
43PRKCQ1.16671903
44FGR1.15496040
45DAPK11.12827751
46BLK1.12330382
47IKBKB1.08241260
48NLK1.07389260
49PASK1.04199716
50MAP3K101.03454579
51PIK3CG1.02770112
52TSSK61.00209403
53CAMK2A0.99309728
54GRK50.98194017
55YES10.96657727
56IRAK40.95009853
57JAK20.93438353
58TYRO30.93284031
59PIM10.92822932
60CSK0.92601397
61FGFR40.89908108
62PRKCH0.88406202
63MAPK110.86912193
64MAP2K40.86655502
65TGFBR20.85853572
66MARK10.84962051
67CAMK2B0.84430700
68CAMKK10.84256811
69HCK0.83974124
70TBK10.83195896
71EPHB10.79494773
72PRKCG0.78855878
73CSF1R0.78651821
74JAK10.77447622
75FGFR30.75421523
76CDK40.75278081
77CSNK1G20.74408777
78CSNK1G30.72590237
79TEC0.72394518
80KIT0.70764737
81MYLK0.70208769
82CDK50.69779789
83MAPK130.68087503
84TESK10.66958984
85DYRK1A0.65918127
86TYK20.65883096
87MUSK0.64368895
88MAP3K90.64293347
89LYN0.63006446
90NUAK10.62345871
91KDR0.62138488
92ARAF0.59065390
93FYN0.58146822
94BCR0.57678277
95MAP2K30.55712270
96ADRBK10.55456330
97KSR10.53624321
98EPHA30.52795213
99TAF10.52235567
100HIPK20.52034656
101VRK10.49996715
102MAPKAPK30.49911094
103CDK190.47580815
104PDK10.46095847
105INSR0.45525995
106MAP3K30.45400592
107BCKDK0.44747987
108MAPK70.44588160
109MAP3K10.43580798
110MAPKAPK20.42768204
111MAPK120.42715522
112CLK10.42622731
113SGK20.42544842
114CDK30.41507485
115PRKD20.41450655
116CDK80.41385288
117RPS6KA50.41377617
118MAP3K70.41103392
119UHMK10.40256171
120ROCK20.39216356
121PRKCE0.38194496
122CSNK1G10.36948269
123TRPM70.36870590
124SGK10.36574325
125CDK180.36268919
126CAMK2G0.35420164
127RPS6KA40.35125894
128BMPR1B0.34509187
129MAP2K60.34472360
130LRRK20.33576394
131CAMK10.33380162
132CSNK1A1L0.32971850
133NEK60.32774943
134MKNK20.32738572
135DAPK20.32234270
136PRKACA0.32117669
137IGF1R0.30316039
138PRKCB0.30268764
139CDK150.29922397
140CDK140.29265278
141TAOK10.28846900
142RAF10.28281950
143STK380.28277990
144IRAK10.26980114
145PDGFRB0.26973671
146CAMK2D0.26861214
147MELK0.26541634
148VRK20.25034267
149STK40.23903830
150ZAK0.23499841
151TAOK20.20770551
152MAP3K50.19842896
153PIK3CA0.18171072
154ATR0.17857796
155FRK0.17589865
156PRKCD0.16248279

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.06854085
2Nicotine addiction_Homo sapiens_hsa050333.72566308
3Graft-versus-host disease_Homo sapiens_hsa053322.96071912
4T cell receptor signaling pathway_Homo sapiens_hsa046602.62255403
5* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.53434408
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.32429184
7Allograft rejection_Homo sapiens_hsa053302.25704261
8Oxidative phosphorylation_Homo sapiens_hsa001902.18840085
9Morphine addiction_Homo sapiens_hsa050322.10444214
10Synaptic vesicle cycle_Homo sapiens_hsa047212.00055985
11Long-term potentiation_Homo sapiens_hsa047201.97350117
12Collecting duct acid secretion_Homo sapiens_hsa049661.96983279
13Autoimmune thyroid disease_Homo sapiens_hsa053201.90302949
14GABAergic synapse_Homo sapiens_hsa047271.85399374
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.84256166
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.80259351
17Type I diabetes mellitus_Homo sapiens_hsa049401.78941926
18Glutamatergic synapse_Homo sapiens_hsa047241.73613941
19Amphetamine addiction_Homo sapiens_hsa050311.72315531
20Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.71526494
21Serotonergic synapse_Homo sapiens_hsa047261.70200290
22Taste transduction_Homo sapiens_hsa047421.69629875
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.69308725
24Phototransduction_Homo sapiens_hsa047441.65850978
25Parkinsons disease_Homo sapiens_hsa050121.60774981
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.57905103
27Alzheimers disease_Homo sapiens_hsa050101.56903979
28Circadian entrainment_Homo sapiens_hsa047131.51564874
29Olfactory transduction_Homo sapiens_hsa047401.50933836
30Dopaminergic synapse_Homo sapiens_hsa047281.50435293
31Herpes simplex infection_Homo sapiens_hsa051681.45241860
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37013887
33Rheumatoid arthritis_Homo sapiens_hsa053231.36351000
34Antigen processing and presentation_Homo sapiens_hsa046121.35128467
35Long-term depression_Homo sapiens_hsa047301.34635225
36Renin secretion_Homo sapiens_hsa049241.30867377
37Salivary secretion_Homo sapiens_hsa049701.28781908
38Hematopoietic cell lineage_Homo sapiens_hsa046401.26291528
39Calcium signaling pathway_Homo sapiens_hsa040201.23372837
40* Measles_Homo sapiens_hsa051621.21372041
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20722660
42Malaria_Homo sapiens_hsa051441.13990856
43TNF signaling pathway_Homo sapiens_hsa046681.10733110
44Cocaine addiction_Homo sapiens_hsa050301.06781188
45Cholinergic synapse_Homo sapiens_hsa047251.05610831
46Acute myeloid leukemia_Homo sapiens_hsa052211.05538902
47Huntingtons disease_Homo sapiens_hsa050161.05272268
48Viral myocarditis_Homo sapiens_hsa054161.02243135
49Oxytocin signaling pathway_Homo sapiens_hsa049211.00343165
50Epstein-Barr virus infection_Homo sapiens_hsa051690.99054922
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93952950
52Apoptosis_Homo sapiens_hsa042100.93205883
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93064725
54Staphylococcus aureus infection_Homo sapiens_hsa051500.92397024
55Chemokine signaling pathway_Homo sapiens_hsa040620.89917548
56Cardiac muscle contraction_Homo sapiens_hsa042600.88920460
57Influenza A_Homo sapiens_hsa051640.88157675
58Viral carcinogenesis_Homo sapiens_hsa052030.87994147
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85850932
60HTLV-I infection_Homo sapiens_hsa051660.84064801
61Gastric acid secretion_Homo sapiens_hsa049710.83855585
62Vibrio cholerae infection_Homo sapiens_hsa051100.83243338
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.82451271
64Insulin secretion_Homo sapiens_hsa049110.81984158
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80660707
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79763623
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78474395
68Platelet activation_Homo sapiens_hsa046110.77814035
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76400096
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74599242
71Non-small cell lung cancer_Homo sapiens_hsa052230.70773088
72Toxoplasmosis_Homo sapiens_hsa051450.70297692
73cAMP signaling pathway_Homo sapiens_hsa040240.69963584
74Axon guidance_Homo sapiens_hsa043600.69816727
75Systemic lupus erythematosus_Homo sapiens_hsa053220.69180347
76Osteoclast differentiation_Homo sapiens_hsa043800.66657449
77Pancreatic cancer_Homo sapiens_hsa052120.66462321
78Regulation of autophagy_Homo sapiens_hsa041400.65887240
79African trypanosomiasis_Homo sapiens_hsa051430.64383354
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63381111
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63048712
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.63046961
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62112430
84Legionellosis_Homo sapiens_hsa051340.61009074
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60503147
86Asthma_Homo sapiens_hsa053100.59188208
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57715186
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57436894
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57069990
90Linoleic acid metabolism_Homo sapiens_hsa005910.56737258
91Proteasome_Homo sapiens_hsa030500.52591118
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52585979
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52473767
94Colorectal cancer_Homo sapiens_hsa052100.52056706
95MAPK signaling pathway_Homo sapiens_hsa040100.51568997
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51511966
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.50824549
98Leishmaniasis_Homo sapiens_hsa051400.50325109
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49551864
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48756205
101GnRH signaling pathway_Homo sapiens_hsa049120.48169797
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48057960
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.47745825
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46412763
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43503120
106Choline metabolism in cancer_Homo sapiens_hsa052310.42967195
107Phagosome_Homo sapiens_hsa041450.42034234
108RNA polymerase_Homo sapiens_hsa030200.41954605
109Estrogen signaling pathway_Homo sapiens_hsa049150.41779729
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41569932
111Gap junction_Homo sapiens_hsa045400.39627411
112Non-homologous end-joining_Homo sapiens_hsa034500.39470898
113Chronic myeloid leukemia_Homo sapiens_hsa052200.39254476
114Hepatitis C_Homo sapiens_hsa051600.39134651
115Ras signaling pathway_Homo sapiens_hsa040140.38478813
116Endocytosis_Homo sapiens_hsa041440.37754787
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36365355
118Shigellosis_Homo sapiens_hsa051310.36005030
119B cell receptor signaling pathway_Homo sapiens_hsa046620.35650733
120Salmonella infection_Homo sapiens_hsa051320.35231672
121VEGF signaling pathway_Homo sapiens_hsa043700.34757024
122Melanogenesis_Homo sapiens_hsa049160.33842074
123Inositol phosphate metabolism_Homo sapiens_hsa005620.33828220
124RNA degradation_Homo sapiens_hsa030180.33044249
125Pancreatic secretion_Homo sapiens_hsa049720.32258842
126Tuberculosis_Homo sapiens_hsa051520.32061491
127ErbB signaling pathway_Homo sapiens_hsa040120.31740531
128Hepatitis B_Homo sapiens_hsa051610.31694276
129Pertussis_Homo sapiens_hsa051330.31146555
130Rap1 signaling pathway_Homo sapiens_hsa040150.30970638
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30454207
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30432209
133Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.27033403
134Ribosome_Homo sapiens_hsa030100.24987535
135mRNA surveillance pathway_Homo sapiens_hsa030150.22387458
136DNA replication_Homo sapiens_hsa030300.21996274
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20934194
138Homologous recombination_Homo sapiens_hsa034400.18955748
139FoxO signaling pathway_Homo sapiens_hsa040680.18224940
140Spliceosome_Homo sapiens_hsa030400.17811136
141Pyrimidine metabolism_Homo sapiens_hsa002400.16221680
142Fanconi anemia pathway_Homo sapiens_hsa034600.14848138
143Prolactin signaling pathway_Homo sapiens_hsa049170.14067446
144Alcoholism_Homo sapiens_hsa050340.13417566
145Adipocytokine signaling pathway_Homo sapiens_hsa049200.12471425
146Prostate cancer_Homo sapiens_hsa052150.11674437
147Nitrogen metabolism_Homo sapiens_hsa009100.10523133
148Nucleotide excision repair_Homo sapiens_hsa034200.09421623
149Carbohydrate digestion and absorption_Homo sapiens_hsa049730.08068517
150Caffeine metabolism_Homo sapiens_hsa002320.07384106
151Dorso-ventral axis formation_Homo sapiens_hsa043200.06998588

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