SH2D1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 [PubMed 11689425]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to interleukin-15 (GO:0071350)7.86329152
2* negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.08140919
3* negative regulation of cell killing (GO:0031342)7.08140919
4response to interleukin-15 (GO:0070672)6.97388503
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.22063936
6interferon-gamma production (GO:0032609)5.77765392
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.42889139
8regulation of B cell receptor signaling pathway (GO:0050855)5.15703141
9antigen processing and presentation of endogenous antigen (GO:0019883)5.03775394
10negative thymic T cell selection (GO:0045060)5.01683528
11regulation of gamma-delta T cell differentiation (GO:0045586)4.98565495
12regulation of T cell mediated cytotoxicity (GO:0001914)4.81594771
13negative T cell selection (GO:0043383)4.81090238
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.79223725
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.77206780
16positive regulation of gamma-delta T cell activation (GO:0046645)4.69474212
17regulation of memory T cell differentiation (GO:0043380)4.66769647
18positive regulation of T cell mediated cytotoxicity (GO:0001916)4.63917776
19negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.61890234
20negative regulation of T-helper cell differentiation (GO:0045623)4.50867885
21negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.50867885
22regulation of gamma-delta T cell activation (GO:0046643)4.48900290
23sleep (GO:0030431)4.44943090
24negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.37880815
25tolerance induction (GO:0002507)4.34522363
26mast cell activation (GO:0045576)4.33190136
27* regulation of leukocyte mediated cytotoxicity (GO:0001910)4.30038039
28negative regulation of T cell mediated immunity (GO:0002710)4.24017306
29neutrophil activation involved in immune response (GO:0002283)4.18517044
30* regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.14966854
31* regulation of natural killer cell mediated immunity (GO:0002715)4.14966854
32activated T cell proliferation (GO:0050798)4.09992807
33regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.07472539
34negative regulation of DNA-templated transcription, elongation (GO:0032785)4.03890004
35natural killer cell activation (GO:0030101)3.95537955
36* regulation of cell killing (GO:0031341)3.94269118
37positive regulation of T cell cytokine production (GO:0002726)3.91061551
38* positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.79910126
39leukocyte aggregation (GO:0070486)3.79382012
40regulation of regulatory T cell differentiation (GO:0045589)3.76655114
41cellular defense response (GO:0006968)3.75490282
42neutrophil activation (GO:0042119)3.72152349
43* negative regulation of lymphocyte mediated immunity (GO:0002707)3.68923991
44positive regulation of T cell mediated immunity (GO:0002711)3.66309114
45response to muramyl dipeptide (GO:0032495)3.59992066
46antigen processing and presentation via MHC class Ib (GO:0002475)3.59167948
47regulation of T cell mediated immunity (GO:0002709)3.55352523
48natural killer cell differentiation (GO:0001779)3.53089276
49regulation of germinal center formation (GO:0002634)3.53001251
50negative regulation of alpha-beta T cell differentiation (GO:0046639)3.47028972
51positive thymic T cell selection (GO:0045059)3.46100015
52* positive regulation of cell killing (GO:0031343)3.46036484
53regulation of alpha-beta T cell proliferation (GO:0046640)3.45177858
54positive regulation of alpha-beta T cell proliferation (GO:0046641)3.43912212
55negative regulation of alpha-beta T cell activation (GO:0046636)3.40858486
56negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.37705758
57mast cell degranulation (GO:0043303)3.37616249
58mast cell activation involved in immune response (GO:0002279)3.37616249
59* negative regulation of leukocyte mediated immunity (GO:0002704)3.36824279
60thymic T cell selection (GO:0045061)3.35904367
61regulation of T-helper 1 type immune response (GO:0002825)3.29401549
62granulocyte activation (GO:0036230)3.28854723
63regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.27656710
64regulation of hypersensitivity (GO:0002883)3.27128688
65tumor necrosis factor-mediated signaling pathway (GO:0033209)3.25943323
66leukocyte degranulation (GO:0043299)3.25718314
67dendritic cell chemotaxis (GO:0002407)3.21156077
68cellular extravasation (GO:0045123)3.20728710
69lymph node development (GO:0048535)3.17410244
70regulation of activation of Janus kinase activity (GO:0010533)3.13918224
71positive regulation of defense response to virus by host (GO:0002230)3.11705436
72T cell selection (GO:0045058)3.07625355
73T cell migration (GO:0072678)3.07619869
74* positive regulation of natural killer cell mediated immunity (GO:0002717)3.06829560
75negative regulation of adaptive immune response (GO:0002820)3.02883819
76positive regulation of mast cell activation (GO:0033005)3.01544960
77positive regulation of interleukin-17 production (GO:0032740)3.00784743
78T cell proliferation (GO:0042098)3.00251477
79positive regulation of osteoclast differentiation (GO:0045672)2.99476028
80negative regulation of T cell apoptotic process (GO:0070233)2.98920384
81positive regulation of T-helper 1 type immune response (GO:0002827)2.96502729
82regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.96084086
83positive regulation of heat generation (GO:0031652)2.95809836
84* regulation of lymphocyte mediated immunity (GO:0002706)2.95554705
85positive regulation of prostaglandin secretion (GO:0032308)2.95427756
86regulation of mast cell activation (GO:0033003)2.93055481
87rRNA catabolic process (GO:0016075)2.91028456
88cellular response to prostaglandin stimulus (GO:0071379)2.90425496
89positive regulation of T cell differentiation in thymus (GO:0033089)2.89698645
90* positive regulation of lymphocyte mediated immunity (GO:0002708)2.86359826
91myeloid cell activation involved in immune response (GO:0002275)2.86322668
92positive regulation of macrophage differentiation (GO:0045651)2.85659727
93regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.84442600
94regulation of T cell cytokine production (GO:0002724)2.84426223
95Peyers patch development (GO:0048541)2.82814830
96mucosal-associated lymphoid tissue development (GO:0048537)2.82814830
97* negative regulation of innate immune response (GO:0045824)2.81177465
98regulation of T cell receptor signaling pathway (GO:0050856)2.80921157
99DNA deamination (GO:0045006)2.80848374
100positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.80410559

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.83880276
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.32981321
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.30195914
4RUNX_20019798_ChIP-Seq_JUKART_Human4.30885549
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.63617438
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.38486285
7MYB_26560356_Chip-Seq_TH2_Human2.94295958
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.75988261
9RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.73892677
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.73562426
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.72294443
12FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.68874420
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.62382617
14LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.51739157
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.42377868
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.36562304
17GATA3_27048872_Chip-Seq_THYMUS_Human2.26993764
18GATA3_26560356_Chip-Seq_TH2_Human2.24872998
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.20156157
20UTX_26944678_Chip-Seq_JUKART_Human2.19408556
21MAF_26560356_Chip-Seq_TH1_Human2.12726553
22IRF8_27001747_Chip-Seq_BMDM_Mouse2.09783454
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.06653397
24SCL_19346495_ChIP-Seq_HPC-7_Human2.03644537
25MYB_26560356_Chip-Seq_TH1_Human2.02609628
26RUNX1_22412390_ChIP-Seq_EML_Mouse1.99907684
27LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.87952229
28MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.83856253
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.83488359
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.82800009
31SPI1_23547873_ChIP-Seq_NB4_Human1.81097807
32GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.68212888
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60988690
34CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.59054305
35MAF_26560356_Chip-Seq_TH2_Human1.54263340
36SPI1_23127762_ChIP-Seq_K562_Human1.51751134
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.45690417
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41030661
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40730999
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39664162
41VDR_24787735_ChIP-Seq_THP-1_Human1.39303119
42GATA2_21666600_ChIP-Seq_HMVEC_Human1.36320101
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.27478871
44RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.26962062
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25128578
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25109118
47PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23883524
48IRF1_19129219_ChIP-ChIP_H3396_Human1.22620981
49GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17609518
50SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16471551
51GATA1_19941827_ChIP-Seq_MEL_Mouse1.14222029
52VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14027551
53SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13551439
54BCL6_27268052_Chip-Seq_Bcells_Human1.12508328
55CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12369072
56SPI1_20517297_ChIP-Seq_HL60_Human1.12124686
57RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08835757
58EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08642875
59PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08421191
60BP1_19119308_ChIP-ChIP_Hs578T_Human1.08150739
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07440370
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06350078
63P300_27268052_Chip-Seq_Bcells_Human1.06177690
64CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06099320
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05270610
66PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02348865
67VDR_24763502_ChIP-Seq_THP-1_Human1.00382801
68SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99452814
69STAT1_20625510_ChIP-Seq_HELA_Human0.98672099
70Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94688972
71RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.93964065
72BCOR_27268052_Chip-Seq_Bcells_Human0.92153313
73PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92096171
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91997449
75TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91643517
76SMRT_27268052_Chip-Seq_Bcells_Human0.91034677
77GATA3_26560356_Chip-Seq_TH1_Human0.90322421
78NFE2_27457419_Chip-Seq_LIVER_Mouse0.90237254
79FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90171897
80PU_27001747_Chip-Seq_BMDM_Mouse0.89724190
81IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89091211
82CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88305413
83EGR1_23403033_ChIP-Seq_LIVER_Mouse0.87262349
84STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86024607
85PCGF2_27294783_Chip-Seq_NPCs_Mouse0.85337379
86GATA3_21878914_ChIP-Seq_MCF-7_Human0.85182452
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83261568
88SA1_27219007_Chip-Seq_Bcells_Human0.82842960
89TAF2_19829295_ChIP-Seq_ESCs_Human0.82309123
90GATA1_22025678_ChIP-Seq_K562_Human0.80984498
91GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.79403637
92EZH2_27294783_Chip-Seq_NPCs_Mouse0.78790574
93GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77357214
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.77216350
95AR_20517297_ChIP-Seq_VCAP_Human0.77007203
96MYC_22102868_ChIP-Seq_BL_Human0.76631353
97FOXA1_21572438_ChIP-Seq_LNCaP_Human0.76587536
98CIITA_25753668_ChIP-Seq_RAJI_Human0.75352403
99KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.74739184
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74618745

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.33171002
2MP0001835_abnormal_antigen_presentation4.32871525
3MP0003724_increased_susceptibility_to4.23066606
4MP0003436_decreased_susceptibility_to3.65284199
5MP0000685_abnormal_immune_system3.53237765
6MP0005000_abnormal_immune_tolerance3.25256913
7MP0003763_abnormal_thymus_physiology3.15156385
8MP0001800_abnormal_humoral_immune2.93863966
9MP0006082_CNS_inflammation2.90117186
10MP0002723_abnormal_immune_serum2.75014837
11MP0001790_abnormal_immune_system2.67966884
12MP0005387_immune_system_phenotype2.67966884
13MP0005025_abnormal_response_to2.64353844
14MP0005075_abnormal_melanosome_morpholog2.60163190
15MP0001819_abnormal_immune_cell2.58995531
16MP0002420_abnormal_adaptive_immunity2.58691880
17MP0009785_altered_susceptibility_to2.55739570
18MP0002148_abnormal_hypersensitivity_rea2.54654523
19MP0002452_abnormal_antigen_presenting2.43118480
20MP0002419_abnormal_innate_immunity2.34074228
21MP0003878_abnormal_ear_physiology2.16192330
22MP0005377_hearing/vestibular/ear_phenot2.16192330
23MP0000465_gastrointestinal_hemorrhage2.13124147
24MP0002398_abnormal_bone_marrow2.07682464
25MP0002405_respiratory_system_inflammati2.03863771
26MP0005464_abnormal_platelet_physiology2.00771751
27MP0000703_abnormal_thymus_morphology1.99509800
28MP0000716_abnormal_immune_system1.99131624
29MP0004043_abnormal_pH_regulation1.97921351
30MP0001533_abnormal_skeleton_physiology1.94486578
31MP0004947_skin_inflammation1.94049620
32MP0002722_abnormal_immune_system1.90180001
33MP0000689_abnormal_spleen_morphology1.85731776
34MP0010155_abnormal_intestine_physiology1.68523118
35MP0001845_abnormal_inflammatory_respons1.61631911
36MP0003866_abnormal_defecation1.54898405
37MP0009333_abnormal_splenocyte_physiolog1.53069448
38MP0008877_abnormal_DNA_methylation1.52677244
39MP0002429_abnormal_blood_cell1.52086643
40MP0001348_abnormal_lacrimal_gland1.44243958
41MP0002166_altered_tumor_susceptibility1.40735830
42MP0002876_abnormal_thyroid_physiology1.39031601
43MP0004130_abnormal_muscle_cell1.33805922
44MP0005310_abnormal_salivary_gland1.31819195
45MP0009764_decreased_sensitivity_to1.30971885
46MP0004381_abnormal_hair_follicle1.22233633
47MP0008469_abnormal_protein_level1.21336996
48MP0003828_pulmonary_edema1.18341121
49MP0003252_abnormal_bile_duct1.18188777
50MP0004147_increased_porphyrin_level1.14958024
51MP0001851_eye_inflammation1.13391494
52MP0002933_joint_inflammation1.12718036
53MP0001986_abnormal_taste_sensitivity1.11513253
54MP0002163_abnormal_gland_morphology1.10931959
55MP0002006_tumorigenesis1.10856607
56MP0003195_calcinosis1.08321331
57MP0004142_abnormal_muscle_tone1.04270520
58MP0003787_abnormal_imprinting1.03560888
59MP0000015_abnormal_ear_pigmentation1.02704199
60MP0000858_altered_metastatic_potential1.01287399
61MP0001873_stomach_inflammation0.97378169
62MP0002998_abnormal_bone_remodeling0.97180282
63MP0001501_abnormal_sleep_pattern0.92646735
64MP0003879_abnormal_hair_cell0.92351376
65MP0006054_spinal_hemorrhage0.90710600
66MP0003656_abnormal_erythrocyte_physiolo0.88405570
67MP0009763_increased_sensitivity_to0.86014134
68MP0008872_abnormal_physiological_respon0.85676496
69MP0005390_skeleton_phenotype0.82657076
70MP0005174_abnormal_tail_pigmentation0.80067691
71MP0003303_peritoneal_inflammation0.79273277
72MP0003638_abnormal_response/metabolism_0.76539821
73MP0001853_heart_inflammation0.75829936
74MP0003172_abnormal_lysosome_physiology0.75795468
75MP0008873_increased_physiological_sensi0.73850765
76MP0001765_abnormal_ion_homeostasis0.72871862
77MP0005083_abnormal_biliary_tract0.72718388
78MP0003045_fibrosis0.72714399
79MP0004885_abnormal_endolymph0.72708233
80MP0002019_abnormal_tumor_incidence0.72546284
81MP0003448_altered_tumor_morphology0.68292228
82MP0005379_endocrine/exocrine_gland_phen0.68088967
83MP0005084_abnormal_gallbladder_morpholo0.67972035
84MP0002009_preneoplasia0.63975726
85MP0003011_delayed_dark_adaptation0.61537698
86MP0002102_abnormal_ear_morphology0.60204742
87MP0009765_abnormal_xenobiotic_induced0.59996266
88MP0001346_abnormal_lacrimal_gland0.59979930
89MP0010307_abnormal_tumor_latency0.59933982
90MP0010329_abnormal_lipoprotein_level0.57959929
91MP0001919_abnormal_reproductive_system0.57246017
92MP0005167_abnormal_blood-brain_barrier0.55835778
93MP0003795_abnormal_bone_structure0.53191814
94MP0003183_abnormal_peptide_metabolism0.52217080
95MP0005360_urolithiasis0.52051327
96MP0002132_abnormal_respiratory_system0.51772912
97MP0004145_abnormal_muscle_electrophysio0.50222584
98MP0000249_abnormal_blood_vessel0.49259133
99MP0003690_abnormal_glial_cell0.49019616
100MP0005319_abnormal_enzyme/_coenzyme0.48853230

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)5.55819855
2Myositis (HP:0100614)5.53923623
3T lymphocytopenia (HP:0005403)5.37408374
4Abnormality of T cell number (HP:0011839)5.35378877
5Retrobulbar optic neuritis (HP:0100654)5.28655534
6Optic neuritis (HP:0100653)5.28655534
7Orchitis (HP:0100796)4.92137230
8Abnormal delayed hypersensitivity skin test (HP:0002963)4.53306147
9Abnormality of T cells (HP:0002843)4.42393904
10Severe combined immunodeficiency (HP:0004430)4.31484014
11Encephalitis (HP:0002383)4.19977813
12Abnormality of eosinophils (HP:0001879)4.03790465
13Stomatitis (HP:0010280)3.85804195
14Pustule (HP:0200039)3.82161082
15Keratoconjunctivitis (HP:0001096)3.77107240
16Elevated erythrocyte sedimentation rate (HP:0003565)3.70267770
17Recurrent cutaneous fungal infections (HP:0011370)3.67847873
18Chronic mucocutaneous candidiasis (HP:0002728)3.67847873
19Premature loss of primary teeth (HP:0006323)3.59427734
20Abnormality of T cell physiology (HP:0011840)3.55467291
21Combined immunodeficiency (HP:0005387)3.42670298
22Keratoconjunctivitis sicca (HP:0001097)3.41361209
23Hemiplegia (HP:0002301)3.36654404
24Panhypogammaglobulinemia (HP:0003139)3.24251759
25Recurrent fungal infections (HP:0002841)3.22425785
26Hypoproteinemia (HP:0003075)3.22306430
27Recurrent bacterial skin infections (HP:0005406)3.19064685
28Renal cortical cysts (HP:0000803)3.18883921
29Pulmonary infiltrates (HP:0002113)3.18034596
30Meningitis (HP:0001287)3.17108208
31Recurrent bronchitis (HP:0002837)3.16098998
32Leukocytosis (HP:0001974)3.13025944
33Eosinophilia (HP:0001880)3.09927214
34Joint swelling (HP:0001386)3.07925270
35Recurrent abscess formation (HP:0002722)3.06990976
36Persistence of primary teeth (HP:0006335)2.96456488
37Increased density of long bones (HP:0006392)2.92064355
38Increased IgM level (HP:0003496)2.92028783
39Alveolar cell carcinoma (HP:0006519)2.91557135
40Eczematoid dermatitis (HP:0000976)2.89131608
41Thyroiditis (HP:0100646)2.84451900
42Vasculitis (HP:0002633)2.83521179
43Granulocytopenia (HP:0001913)2.81288822
44Abnormality of macrophages (HP:0004311)2.77784692
45Hemoptysis (HP:0002105)2.77017714
46Arterial thrombosis (HP:0004420)2.71459509
47Stomach cancer (HP:0012126)2.70394038
48Recurrent skin infections (HP:0001581)2.68132152
49Clumsiness (HP:0002312)2.67218547
50Gastrointestinal infarctions (HP:0005244)2.65177216
51Amyotrophic lateral sclerosis (HP:0007354)2.63080105
52Abnormality of B cell number (HP:0010975)2.59616446
53Conical tooth (HP:0000698)2.56978627
54Neoplasm of the tracheobronchial system (HP:0100552)2.53828440
55IgM deficiency (HP:0002850)2.50096632
56Keratitis (HP:0000491)2.46767448
57Anorexia (HP:0002039)2.44720494
58Facial diplegia (HP:0001349)2.28575594
59B lymphocytopenia (HP:0010976)2.26295939
60Dysostosis multiplex (HP:0000943)2.23928946
61Mediastinal lymphadenopathy (HP:0100721)2.23112644
62Petechiae (HP:0000967)2.21925931
63Pulmonary embolism (HP:0002204)2.21355462
64Anhidrosis (HP:0000970)2.21219168
65Abnormality of glycolipid metabolism (HP:0010969)2.20391558
66Abnormality of liposaccharide metabolism (HP:0010968)2.20391558
67Abnormality of glycosphingolipid metabolism (HP:0004343)2.20391558
68Prolonged bleeding time (HP:0003010)2.16708387
69Vertigo (HP:0002321)2.15873868
70Gangrene (HP:0100758)2.15550376
71Abnormality of the renal cortex (HP:0011035)2.15184568
72Hypochromic anemia (HP:0001931)2.14788177
73Chest pain (HP:0100749)2.13163024
74Inflammation of the large intestine (HP:0002037)2.13082295
75Abnormality of the pleura (HP:0002103)2.11265848
76Hypoplasia of the thymus (HP:0000778)2.08203255
77Cutaneous melanoma (HP:0012056)2.07966164
78Abnormality of mucopolysaccharide metabolism (HP:0011020)2.07217237
79Abnormality of polysaccharide metabolism (HP:0011012)2.07217237
80Abnormality of glycosaminoglycan metabolism (HP:0004371)2.07217237
81Bronchitis (HP:0012387)2.06180796
82Gingival bleeding (HP:0000225)2.04287484
83Abnormality of the endocardium (HP:0004306)2.03862979
84Autoimmune thrombocytopenia (HP:0001973)2.03263612
85Gastrointestinal inflammation (HP:0004386)1.92127520
86Epistaxis (HP:0000421)1.91928912
87Arthralgia (HP:0002829)1.91345985
88Adactyly (HP:0009776)1.90908293
89Spontaneous hematomas (HP:0007420)1.89985201
90Visual hallucinations (HP:0002367)1.82868260
91Abnormality of the radial head (HP:0003995)1.82499710
92Dislocated radial head (HP:0003083)1.81970254
93Abnormality of cells of the lymphoid lineage (HP:0012140)1.81176889
94Increased CSF protein (HP:0002922)1.79224619
95Polyneuropathy (HP:0001271)1.78013765
96Agitation (HP:0000713)1.77361358
97Attenuation of retinal blood vessels (HP:0007843)1.77145721
98Brittle hair (HP:0002299)1.76580731
99Urinary glycosaminoglycan excretion (HP:0003541)1.76485116
100Mucopolysacchariduria (HP:0008155)1.76485116

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.07682838
2MAP3K143.95019482
3GRK63.85871440
4MAP4K13.32043225
5BMPR23.16576159
6FES3.02807435
7TAOK32.85570540
8MAP4K22.55454374
9TESK22.54127058
10MAP2K22.42557670
11JAK12.31634715
12JAK32.12806902
13IKBKE2.09583193
14TLK12.06863821
15IKBKB1.94952565
16RIPK41.93415263
17TBK11.86552062
18BTK1.83216459
19MUSK1.73115611
20TNK21.59860172
21MARK31.51102745
22SYK1.49900421
23ZAP701.48937365
24LCK1.48709175
25ACVR1B1.44086293
26CSK1.42998930
27ITK1.41931030
28KIT1.35253264
29SIK21.32989274
30MAP3K131.28177003
31LYN1.25891100
32HCK1.24891488
33KDR1.21869772
34SIK31.21211621
35NUAK11.20771604
36TYK21.12319386
37TEC1.08737120
38ADRBK21.07511133
39CSF1R1.06326552
40MATK1.04467909
41CAMKK21.00194545
42IRAK40.97329570
43PIM10.96997521
44BLK0.95856401
45PRKCQ0.94163943
46CDK30.93889123
47LIMK10.83407591
48ERN10.82841558
49ZAK0.81906744
50FGR0.71911613
51PIK3CG0.70766638
52STK100.67968925
53CAMKK10.66667500
54CDK40.66389146
55GRK10.66157933
56GRK70.62800968
57WNK40.62784344
58MAP3K40.59495528
59EIF2AK20.59308143
60PDK10.59104688
61IGF1R0.56991713
62CHUK0.55063546
63MAPK70.50323288
64PRKCH0.50098263
65RAF10.47846055
66NEK60.47071778
67FYN0.43469749
68MAP2K10.43158444
69JAK20.42352260
70MAPKAPK20.41489522
71MAPK110.41319724
72ABL10.39760022
73FRK0.38441002
74MAPK120.37178488
75MAPK130.36869969
76INSR0.33624701
77BCKDK0.33194853
78CDC42BPA0.33072516
79MAP2K60.32928762
80KSR20.31308397
81STK110.29490588
82MAPKAPK30.28525137
83TGFBR20.26177083
84RPS6KA20.22912049
85MOS0.22822538
86BCR0.22501724
87EPHB10.22499848
88NME10.22442640
89PRKCD0.20475696
90EGFR0.20367868
91BRD40.18628554
92ADRBK10.18555386
93OXSR10.17179063
94KSR10.15795268
95MAP2K30.15714443
96PTK2B0.15456824
97PINK10.12284322
98PTK60.12160878
99GRK50.12000266
100MAPK30.11707294

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.61471978
2* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046504.09346427
3Primary immunodeficiency_Homo sapiens_hsa053404.08261508
4Allograft rejection_Homo sapiens_hsa053302.91648852
5Antigen processing and presentation_Homo sapiens_hsa046122.83469723
6Autoimmune thyroid disease_Homo sapiens_hsa053202.75873983
7T cell receptor signaling pathway_Homo sapiens_hsa046602.42450405
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.35182312
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.26791360
10Type I diabetes mellitus_Homo sapiens_hsa049402.23659564
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.21534691
12Osteoclast differentiation_Homo sapiens_hsa043802.17538883
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.16153321
14B cell receptor signaling pathway_Homo sapiens_hsa046622.14314888
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.00373603
16Leishmaniasis_Homo sapiens_hsa051401.90366123
17Measles_Homo sapiens_hsa051621.84574729
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.69823270
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.69738664
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67130797
21Malaria_Homo sapiens_hsa051441.62528238
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.59822449
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.49713022
24Hematopoietic cell lineage_Homo sapiens_hsa046401.44423380
25Viral myocarditis_Homo sapiens_hsa054161.43822348
26TNF signaling pathway_Homo sapiens_hsa046681.35254339
27Herpes simplex infection_Homo sapiens_hsa051681.34073217
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.30931977
29Chemokine signaling pathway_Homo sapiens_hsa040621.27396060
30Asthma_Homo sapiens_hsa053101.26937497
31Staphylococcus aureus infection_Homo sapiens_hsa051501.23863735
32Nitrogen metabolism_Homo sapiens_hsa009101.21191116
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.19734162
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14401990
35Tuberculosis_Homo sapiens_hsa051521.14156907
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12006937
37Acute myeloid leukemia_Homo sapiens_hsa052211.09819353
38Apoptosis_Homo sapiens_hsa042101.09762587
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09420780
40Rheumatoid arthritis_Homo sapiens_hsa053231.05919179
41Toxoplasmosis_Homo sapiens_hsa051450.93098810
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92363277
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89149976
44Platelet activation_Homo sapiens_hsa046110.89071655
45Legionellosis_Homo sapiens_hsa051340.81766573
46Shigellosis_Homo sapiens_hsa051310.79386073
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77339442
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76334375
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75040602
50Hepatitis B_Homo sapiens_hsa051610.74730313
51Influenza A_Homo sapiens_hsa051640.73888921
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72603543
53African trypanosomiasis_Homo sapiens_hsa051430.72026873
54Lysosome_Homo sapiens_hsa041420.68664101
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.65375344
56Pertussis_Homo sapiens_hsa051330.64457052
57Circadian rhythm_Homo sapiens_hsa047100.63569846
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.58045844
59Hepatitis C_Homo sapiens_hsa051600.57294831
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57278085
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54178535
62Non-small cell lung cancer_Homo sapiens_hsa052230.52948412
63Arachidonic acid metabolism_Homo sapiens_hsa005900.52934644
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52924891
65Linoleic acid metabolism_Homo sapiens_hsa005910.52685517
66Prolactin signaling pathway_Homo sapiens_hsa049170.48993628
67Sulfur metabolism_Homo sapiens_hsa009200.48116286
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47568697
69Morphine addiction_Homo sapiens_hsa050320.45703489
70Endocytosis_Homo sapiens_hsa041440.44061133
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43691339
72Phototransduction_Homo sapiens_hsa047440.43555525
73HTLV-I infection_Homo sapiens_hsa051660.43015696
74Inositol phosphate metabolism_Homo sapiens_hsa005620.41902631
75Insulin resistance_Homo sapiens_hsa049310.40576101
76Epstein-Barr virus infection_Homo sapiens_hsa051690.40220602
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39375052
78ABC transporters_Homo sapiens_hsa020100.38572911
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33874528
80Viral carcinogenesis_Homo sapiens_hsa052030.33419482
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31557369
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.30854017
83MAPK signaling pathway_Homo sapiens_hsa040100.30139706
84Glycerolipid metabolism_Homo sapiens_hsa005610.29438678
85Caffeine metabolism_Homo sapiens_hsa002320.29064981
86Ether lipid metabolism_Homo sapiens_hsa005650.27711278
87FoxO signaling pathway_Homo sapiens_hsa040680.27589322
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.24153987
89Regulation of autophagy_Homo sapiens_hsa041400.24145952
90Phagosome_Homo sapiens_hsa041450.24087817
91Olfactory transduction_Homo sapiens_hsa047400.23498777
92cAMP signaling pathway_Homo sapiens_hsa040240.23459346
93Choline metabolism in cancer_Homo sapiens_hsa052310.22704769
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.21259759
95VEGF signaling pathway_Homo sapiens_hsa043700.20437108
96RNA degradation_Homo sapiens_hsa030180.19240525
97Pancreatic cancer_Homo sapiens_hsa052120.19049518
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.18555570
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.17128003
100Oxytocin signaling pathway_Homo sapiens_hsa049210.15271208

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