ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.44168302
2	fucose catabolic process (GO:0019317)	5.37001752
3	L-fucose metabolic process (GO:0042354)	5.37001752
4	L-fucose catabolic process (GO:0042355)	5.37001752
5	DNA deamination (GO:0045006)	4.96688679
6	kynurenine metabolic process (GO:0070189)	4.21136192
7	tryptophan catabolic process (GO:0006569)	4.12812189
8	indole-containing compound catabolic process (GO:0042436)	4.12812189
9	indolalkylamine catabolic process (GO:0046218)	4.12812189
10	regulation of hippo signaling (GO:0035330)	3.95477373
11	indolalkylamine metabolic process (GO:0006586)	3.76541405
12	water-soluble vitamin biosynthetic process (GO:0042364)	3.54932888
13	cellular response to ATP (GO:0071318)	3.40657133
14	kidney morphogenesis (GO:0060993)	3.39048984
15	sulfation (GO:0051923)	3.36080971
16	tryptophan metabolic process (GO:0006568)	3.33829368
17	neural tube formation (GO:0001841)	3.28223182
18	negative regulation of telomere maintenance (GO:0032205)	3.21342492
19	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.19941327
20	cornea development in camera-type eye (GO:0061303)	3.16505231
21	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.15969533
22	positive regulation of defense response to virus by host (GO:0002230)	3.12171936
23	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.09901914
24	response to pheromone (GO:0019236)	3.08813202
25	detection of light stimulus involved in sensory perception (GO:0050962)	3.08313575
26	detection of light stimulus involved in visual perception (GO:0050908)	3.08313575
27	fucosylation (GO:0036065)	3.07310085
28	piRNA metabolic process (GO:0034587)	3.04942041
29	preassembly of GPI anchor in ER membrane (GO:0016254)	3.03874343
30	cellular ketone body metabolic process (GO:0046950)	3.03563043
31	rRNA catabolic process (GO:0016075)	2.99569994
32	regulation of posttranscriptional gene silencing (GO:0060147)	2.94291248
33	regulation of gene silencing by miRNA (GO:0060964)	2.94291248
34	regulation of gene silencing by RNA (GO:0060966)	2.94291248
35	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.91940983
36	platelet dense granule organization (GO:0060155)	2.90467789
37	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.88026066
38	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.88026066
39	NADH dehydrogenase complex assembly (GO:0010257)	2.88026066
40	protein complex biogenesis (GO:0070271)	2.87824912
41	indole-containing compound metabolic process (GO:0042430)	2.87290936
42	positive regulation of triglyceride biosynthetic process (GO:0010867)	2.85431981
43	neuronal action potential (GO:0019228)	2.82493601
44	negative regulation of mast cell activation (GO:0033004)	2.81730846
45	respiratory chain complex IV assembly (GO:0008535)	2.80055666
46	protein K11-linked deubiquitination (GO:0035871)	2.76724036
47	axoneme assembly (GO:0035082)	2.76317881
48	endoderm formation (GO:0001706)	2.76005449
49	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.75735364
50	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.75735364
51	cytidine metabolic process (GO:0046087)	2.73421456
52	cytidine catabolic process (GO:0006216)	2.73421456
53	cytidine deamination (GO:0009972)	2.73421456
54	regulation of action potential (GO:0098900)	2.73141729
55	tRNA modification (GO:0006400)	2.72778109
56	spinal cord motor neuron differentiation (GO:0021522)	2.71705586
57	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.71635908
58	DNA methylation involved in gamete generation (GO:0043046)	2.70983413
59	regulation of mesoderm development (GO:2000380)	2.70424275
60	NAD biosynthetic process (GO:0009435)	2.70219111
61	negative regulation of systemic arterial blood pressure (GO:0003085)	2.70011488
62	ketone body metabolic process (GO:1902224)	2.68957269
63	pseudouridine synthesis (GO:0001522)	2.65509577
64	regulation of triglyceride biosynthetic process (GO:0010866)	2.65468309
65	positive regulation of fatty acid transport (GO:2000193)	2.64424046
66	cytochrome complex assembly (GO:0017004)	2.62331869
67	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.60794651
68	mitochondrial respiratory chain complex assembly (GO:0033108)	2.60770209
69	negative regulation of T cell differentiation in thymus (GO:0033085)	2.59798000
70	amine catabolic process (GO:0009310)	2.59265069
71	cellular biogenic amine catabolic process (GO:0042402)	2.59265069
72	keratinocyte development (GO:0003334)	2.58127818
73	mannosylation (GO:0097502)	2.58006064
74	drug catabolic process (GO:0042737)	2.57056638
75	GPI anchor metabolic process (GO:0006505)	2.56604599
76	oxidative demethylation (GO:0070989)	2.55510482
77	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.53834769
78	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.53557991
79	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.53503090
80	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.53503090
81	multicellular organism reproduction (GO:0032504)	2.51215597
82	flavonoid metabolic process (GO:0009812)	2.48460370
83	reflex (GO:0060004)	2.48414373
84	thyroid hormone metabolic process (GO:0042403)	2.48318603
85	ubiquinone biosynthetic process (GO:0006744)	2.48301474
86	cellular response to exogenous dsRNA (GO:0071360)	2.47756830
87	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.47399178
88	regulation of translation, ncRNA-mediated (GO:0045974)	2.47399178
89	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.47399178
90	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.47333345
91	rhodopsin mediated signaling pathway (GO:0016056)	2.47303408
92	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.47226204
93	nephron epithelium morphogenesis (GO:0072088)	2.46661786
94	nephron tubule morphogenesis (GO:0072078)	2.46661786
95	epithelial cilium movement (GO:0003351)	2.46466965
96	cilium or flagellum-dependent cell motility (GO:0001539)	2.44248895
97	protein-cofactor linkage (GO:0018065)	2.43820150
98	tRNA processing (GO:0008033)	2.42819346
99	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.41263735
100	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.40996294

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.54761305
2	VDR_22108803_ChIP-Seq_LS180_Human	3.34542864
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.54712979
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.42353735
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.30646320
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.26051099
7	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.24882357
8	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.23122697
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.10024236
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.07203614
11	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.02554892
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.92273927
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.91370310
14	EWS_26573619_Chip-Seq_HEK293_Human	1.86347135
15	EZH2_22144423_ChIP-Seq_EOC_Human	1.86280898
16	ER_23166858_ChIP-Seq_MCF-7_Human	1.83200783
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.81785508
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.80974801
19	IRF1_19129219_ChIP-ChIP_H3396_Human	1.77426526
20	TP53_22573176_ChIP-Seq_HFKS_Human	1.77210744
21	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.70120332
22	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.64671739
23	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.64671739
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.62957189
25	FUS_26573619_Chip-Seq_HEK293_Human	1.62480863
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.61805736
27	BCAT_22108803_ChIP-Seq_LS180_Human	1.57905543
28	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.56225544
29	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.54897420
30	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.52792693
31	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.50384017
32	ERA_21632823_ChIP-Seq_H3396_Human	1.49794616
33	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.46921541
34	NCOR_22424771_ChIP-Seq_293T_Human	1.45863059
35	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.45266166
36	IGF1R_20145208_ChIP-Seq_DFB_Human	1.45178017
37	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.43802035
38	P300_19829295_ChIP-Seq_ESCs_Human	1.42768685
39	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.41561952
40	AR_20517297_ChIP-Seq_VCAP_Human	1.41436992
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.39969368
42	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.39492822
43	HOXB7_26014856_ChIP-Seq_BT474_Human	1.38197643
44	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.37709991
45	CBP_20019798_ChIP-Seq_JUKART_Human	1.37709991
46	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.31984388
47	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.31355818
48	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.31355818
49	NANOG_20526341_ChIP-Seq_ESCs_Human	1.29964316
50	P53_21459846_ChIP-Seq_SAOS-2_Human	1.29178479
51	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.27907557
52	AR_25329375_ChIP-Seq_VCAP_Human	1.27315627
53	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.26371388
54	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.26261426
55	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.24786634
56	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.22480559
57	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.21958721
58	STAT3_23295773_ChIP-Seq_U87_Human	1.21440687
59	TCF4_23295773_ChIP-Seq_U87_Human	1.18211179
60	TAF15_26573619_Chip-Seq_HEK293_Human	1.17438043
61	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.16509203
62	* TAF2_19829295_ChIP-Seq_ESCs_Human	1.16098083
63	GATA3_26560356_Chip-Seq_TH2_Human	1.15411942
64	NANOG_19829295_ChIP-Seq_ESCs_Human	1.14402894
65	SOX2_19829295_ChIP-Seq_ESCs_Human	1.14402894
66	* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.14302954
67	REST_21632747_ChIP-Seq_MESCs_Mouse	1.14155369
68	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.13083460
69	OCT4_20526341_ChIP-Seq_ESCs_Human	1.12903437
70	MYC_19829295_ChIP-Seq_ESCs_Human	1.12804206
71	TCF4_22108803_ChIP-Seq_LS180_Human	1.12467231
72	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.11379007
73	VDR_23849224_ChIP-Seq_CD4+_Human	1.09659802
74	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.09407798
75	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09251035
76	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.09030377
77	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.08560063
78	AR_21572438_ChIP-Seq_LNCaP_Human	1.08515114
79	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.08170410
80	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.06797377
81	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05838308
82	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.04931195
83	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.04258715
84	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.03948863
85	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.03152866
86	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03081889
87	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.02505627
88	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.02190591
89	RAC3_21632823_ChIP-Seq_H3396_Human	1.00341727
90	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.98064151
91	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97078613
92	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.96054108
93	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.95953634
94	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.95295068
95	RUNX2_22187159_ChIP-Seq_PCA_Human	0.95088920
96	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.94838840
97	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93931599
98	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.92194359
99	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.91762450
100	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.91268439

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.58496492
2	MP0003195_calcinosis	2.77277957
3	MP0004043_abnormal_pH_regulation	2.70445205
4	MP0001873_stomach_inflammation	2.51063671
5	MP0008875_abnormal_xenobiotic_pharmacok	2.48495966
6	MP0005174_abnormal_tail_pigmentation	2.42055543
7	MP0001968_abnormal_touch/_nociception	2.38694589
8	MP0003646_muscle_fatigue	2.29040983
9	MP0001986_abnormal_taste_sensitivity	2.28005358
10	MP0008872_abnormal_physiological_respon	2.20684274
11	MP0003136_yellow_coat_color	2.14791791
12	MP0005551_abnormal_eye_electrophysiolog	2.08760311
13	MP0000427_abnormal_hair_cycle	2.05560513
14	MP0002102_abnormal_ear_morphology	1.99454908
15	MP0000383_abnormal_hair_follicle	1.96656754
16	MP0002736_abnormal_nociception_after	1.80934890
17	MP0002876_abnormal_thyroid_physiology	1.79677688
18	MP0008877_abnormal_DNA_methylation	1.77865219
19	MP0005645_abnormal_hypothalamus_physiol	1.75576605
20	MP0001485_abnormal_pinna_reflex	1.71279255
21	MP0005646_abnormal_pituitary_gland	1.66769811
22	MP0002138_abnormal_hepatobiliary_system	1.65950256
23	MP0000569_abnormal_digit_pigmentation	1.62166650
24	MP0004381_abnormal_hair_follicle	1.59130305
25	MP0002234_abnormal_pharynx_morphology	1.58900776
26	MP0004885_abnormal_endolymph	1.55867362
27	MP0001919_abnormal_reproductive_system	1.53286830
28	MP0001501_abnormal_sleep_pattern	1.51705925
29	MP0004133_heterotaxia	1.49410097
30	MP0005389_reproductive_system_phenotype	1.47600564
31	MP0005075_abnormal_melanosome_morpholog	1.45631750
32	MP0000631_abnormal_neuroendocrine_gland	1.41387535
33	MP0009745_abnormal_behavioral_response	1.37048702
34	MP0002254_reproductive_system_inflammat	1.32018322
35	MP0003011_delayed_dark_adaptation	1.29509128
36	MP0010678_abnormal_skin_adnexa	1.28699700
37	MP0002733_abnormal_thermal_nociception	1.28587992
38	MP0003878_abnormal_ear_physiology	1.27615120
39	MP0005377_hearing/vestibular/ear_phenot	1.27615120
40	MP0005253_abnormal_eye_physiology	1.21851168
41	MP0006072_abnormal_retinal_apoptosis	1.21479898
42	MP0002938_white_spotting	1.20903324
43	MP0002653_abnormal_ependyma_morphology	1.19755290
44	MP0004142_abnormal_muscle_tone	1.18991846
45	MP0001765_abnormal_ion_homeostasis	1.18781273
46	MP0002277_abnormal_respiratory_mucosa	1.17546596
47	MP0002160_abnormal_reproductive_system	1.13498212
48	MP0005671_abnormal_response_to	1.12162849
49	MP0002163_abnormal_gland_morphology	1.11971438
50	MP0004742_abnormal_vestibular_system	1.11710811
51	MP0001970_abnormal_pain_threshold	1.10563238
52	MP0009046_muscle_twitch	1.10418786
53	MP0000538_abnormal_urinary_bladder	1.10075501
54	MP0002095_abnormal_skin_pigmentation	1.09859122
55	MP0000015_abnormal_ear_pigmentation	1.08632404
56	MP0002928_abnormal_bile_duct	1.06170693
57	MP0004147_increased_porphyrin_level	1.05443151
58	MP0005360_urolithiasis	1.02543883
59	MP0003718_maternal_effect	1.01225365
60	MP0002837_dystrophic_cardiac_calcinosis	1.00925730
61	MP0005410_abnormal_fertilization	1.00694055
62	MP0000470_abnormal_stomach_morphology	0.99286901
63	MP0005083_abnormal_biliary_tract	0.99239159
64	MP0002735_abnormal_chemical_nociception	0.98303701
65	MP0008995_early_reproductive_senescence	0.97893608
66	MP0001764_abnormal_homeostasis	0.96151543
67	MP0002272_abnormal_nervous_system	0.95308242
68	MP0002693_abnormal_pancreas_physiology	0.94634576
69	MP0000372_irregular_coat_pigmentation	0.94432239
70	MP0003787_abnormal_imprinting	0.94190686
71	MP0001502_abnormal_circadian_rhythm	0.93844167
72	MP0002638_abnormal_pupillary_reflex	0.93759962
73	MP0008961_abnormal_basal_metabolism	0.93611678
74	MP0001800_abnormal_humoral_immune	0.93326554
75	MP0001663_abnormal_digestive_system	0.92988896
76	MP0005310_abnormal_salivary_gland	0.91621254
77	MP0004019_abnormal_vitamin_homeostasis	0.91338091
78	MP0000230_abnormal_systemic_arterial	0.90496686
79	MP0003252_abnormal_bile_duct	0.89021444
80	MP0003806_abnormal_nucleotide_metabolis	0.88855337
81	MP0001664_abnormal_digestion	0.87370089
82	MP0001905_abnormal_dopamine_level	0.86390322
83	MP0000026_abnormal_inner_ear	0.86356667
84	MP0000647_abnormal_sebaceous_gland	0.86079536
85	MP0009764_decreased_sensitivity_to	0.85898149
86	MP0005085_abnormal_gallbladder_physiolo	0.85692197
87	MP0006276_abnormal_autonomic_nervous	0.85032951
88	MP0002098_abnormal_vibrissa_morphology	0.84310792
89	MP0005332_abnormal_amino_acid	0.84050311
90	MP0004924_abnormal_behavior	0.83826802
91	MP0005386_behavior/neurological_phenoty	0.83826802
92	MP0000685_abnormal_immune_system	0.83213531
93	MP0005448_abnormal_energy_balance	0.81619831
94	MP0005379_endocrine/exocrine_gland_phen	0.81478646
95	MP0005195_abnormal_posterior_eye	0.81195119
96	MP0001324_abnormal_eye_pigmentation	0.78095381
97	MP0002557_abnormal_social/conspecific_i	0.77695362
98	MP0003119_abnormal_digestive_system	0.76123840
99	MP0002148_abnormal_hypersensitivity_rea	0.75305161
100	MP0002933_joint_inflammation	0.74073697

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.56091971
2	Congenital stationary night blindness (HP:0007642)	4.25099664
3	Pancreatic fibrosis (HP:0100732)	3.76450839
4	Molar tooth sign on MRI (HP:0002419)	3.70464605
5	Abnormality of midbrain morphology (HP:0002418)	3.70464605
6	True hermaphroditism (HP:0010459)	3.62496101
7	Attenuation of retinal blood vessels (HP:0007843)	3.39952915
8	Nephronophthisis (HP:0000090)	3.35738531
9	Abnormality of the renal cortex (HP:0011035)	3.28133393
10	Pendular nystagmus (HP:0012043)	3.26253761
11	Hyperalaninemia (HP:0003348)	3.15609459
12	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.15609459
13	Abnormality of alanine metabolism (HP:0010916)	3.15609459
14	Tubular atrophy (HP:0000092)	3.12245332
15	Abnormality of the renal medulla (HP:0100957)	3.08515366
16	Decreased circulating renin level (HP:0003351)	3.04532669
17	Type II lissencephaly (HP:0007260)	3.00178779
18	Cystic liver disease (HP:0006706)	2.92933612
19	Hyperventilation (HP:0002883)	2.82954806
20	Congenital sensorineural hearing impairment (HP:0008527)	2.82421663
21	Genetic anticipation (HP:0003743)	2.75819976
22	Concave nail (HP:0001598)	2.68349381
23	Cerebellar dysplasia (HP:0007033)	2.67600503
24	Abnormal drinking behavior (HP:0030082)	2.65380007
25	Polydipsia (HP:0001959)	2.65380007
26	Abnormality of the pons (HP:0007361)	2.57757182
27	Abolished electroretinogram (ERG) (HP:0000550)	2.57649925
28	Furrowed tongue (HP:0000221)	2.52725089
29	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.52338592
30	Chorioretinal atrophy (HP:0000533)	2.49685548
31	Clumsiness (HP:0002312)	2.46448300
32	Chronic hepatic failure (HP:0100626)	2.45878027
33	Abnormality of the renal collecting system (HP:0004742)	2.43635643
34	Hypoplasia of the pons (HP:0012110)	2.42638299
35	Large for gestational age (HP:0001520)	2.41971518
36	Progressive cerebellar ataxia (HP:0002073)	2.40275387
37	Congenital, generalized hypertrichosis (HP:0004540)	2.39916858
38	Stomach cancer (HP:0012126)	2.39102606
39	Abnormal rod and cone electroretinograms (HP:0008323)	2.29825028
40	Duplicated collecting system (HP:0000081)	2.29106473
41	Medial flaring of the eyebrow (HP:0010747)	2.25876963
42	Inability to walk (HP:0002540)	2.25228819
43	Gaze-evoked nystagmus (HP:0000640)	2.22934111
44	Patellar aplasia (HP:0006443)	2.20898658
45	Decreased central vision (HP:0007663)	2.19343062
46	Aplasia/Hypoplasia of the patella (HP:0006498)	2.17827854
47	Birth length less than 3rd percentile (HP:0003561)	2.16612147
48	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.13932860
49	Absent/shortened dynein arms (HP:0200106)	2.13932860
50	Lissencephaly (HP:0001339)	2.13401490
51	Polyuria (HP:0000103)	2.13272885
52	Protruding tongue (HP:0010808)	2.11019695
53	Abnormal number of erythroid precursors (HP:0012131)	2.08707947
54	Sclerocornea (HP:0000647)	2.03908132
55	Progressive inability to walk (HP:0002505)	2.03685094
56	Stomatitis (HP:0010280)	2.03570648
57	Congenital hepatic fibrosis (HP:0002612)	2.03226032
58	Severe muscular hypotonia (HP:0006829)	2.02845027
59	Abnormality of renin-angiotensin system (HP:0000847)	2.00499875
60	Abnormal biliary tract physiology (HP:0012439)	2.00474552
61	Bile duct proliferation (HP:0001408)	2.00474552
62	Renal cortical cysts (HP:0000803)	1.97945624
63	Constricted visual fields (HP:0001133)	1.97212925
64	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.96468099
65	Bony spicule pigmentary retinopathy (HP:0007737)	1.94475094
66	Amelogenesis imperfecta (HP:0000705)	1.91105581
67	Abnormal respiratory epithelium morphology (HP:0012253)	1.90886743
68	Abnormal respiratory motile cilium morphology (HP:0005938)	1.90886743
69	Rib fusion (HP:0000902)	1.87156536
70	Anencephaly (HP:0002323)	1.86834668
71	Absent thumb (HP:0009777)	1.85209729
72	Aplasia/hypoplasia of the uterus (HP:0008684)	1.84843517
73	Methylmalonic aciduria (HP:0012120)	1.84441414
74	Small hand (HP:0200055)	1.84384674
75	Tachypnea (HP:0002789)	1.82559911
76	Methylmalonic acidemia (HP:0002912)	1.80182115
77	Abnormal albumin level (HP:0012116)	1.79825006
78	Hypoalbuminemia (HP:0003073)	1.79825006
79	Ketoacidosis (HP:0001993)	1.78707730
80	Hypomagnesemia (HP:0002917)	1.78472406
81	Male pseudohermaphroditism (HP:0000037)	1.76910564
82	Ketosis (HP:0001946)	1.76358783
83	3-Methylglutaconic aciduria (HP:0003535)	1.75475741
84	Increased corneal curvature (HP:0100692)	1.75082531
85	Keratoconus (HP:0000563)	1.75082531
86	Broad-based gait (HP:0002136)	1.74182154
87	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.72762502
88	IgG deficiency (HP:0004315)	1.72188721
89	Pustule (HP:0200039)	1.71419051
90	Oligodontia (HP:0000677)	1.70809321
91	Fair hair (HP:0002286)	1.70300467
92	Abnormality of renal excretion (HP:0011036)	1.70126217
93	Hypoplasia of the uterus (HP:0000013)	1.69787987
94	Abnormality of cells of the erythroid lineage (HP:0012130)	1.68697063
95	Abnormal urine output (HP:0012590)	1.68628863
96	Mitochondrial inheritance (HP:0001427)	1.67271564
97	Optic disc pallor (HP:0000543)	1.66353187
98	Increased CSF lactate (HP:0002490)	1.65253507
99	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.65121957
100	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.64235580

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.10486947
2	TNIK	3.81082710
3	ADRBK2	3.55175001
4	ACVR1B	3.47684984
5	TLK1	3.37680229
6	ZAK	3.35968189
7	BMPR1B	3.02104309
8	TAOK3	2.91601866
9	WNK4	2.86172809
10	GRK1	2.60843813
11	NUAK1	1.96651862
12	MAP4K2	1.94746772
13	CASK	1.87233107
14	TXK	1.82272600
15	NLK	1.66284074
16	WNK3	1.65094051
17	MAPK15	1.62409211
18	MAP4K1	1.60808555
19	PINK1	1.51435783
20	OXSR1	1.50899061
21	DAPK2	1.46719061
22	ADRBK1	1.42458242
23	MAPK13	1.41360619
24	STK39	1.40560057
25	EPHA2	1.37173943
26	KIT	1.34783031
27	TGFBR1	1.31137678
28	MAP2K6	1.29387543
29	INSRR	1.28378579
30	IKBKB	1.25248700
31	MST1R	1.18901348
32	MUSK	1.00087579
33	GRK6	0.99385949
34	TRIM28	0.98869603
35	PRKCI	0.91088410
36	CHUK	0.84625260
37	MAPKAPK3	0.83754007
38	SIK2	0.79659744
39	PAK3	0.77148105
40	IKBKE	0.76193489
41	IRAK1	0.72957343
42	MST4	0.71810313
43	ITK	0.70544741
44	PRKCQ	0.69878925
45	NME1	0.69068259
46	DYRK2	0.67847141
47	BRSK2	0.65863889
48	SYK	0.65415577
49	MKNK2	0.65159957
50	PRKCE	0.64350178
51	MAP3K4	0.64289913
52	TEC	0.64083791
53	PTK2B	0.62757572
54	PHKG1	0.62215002
55	PHKG2	0.62215002
56	VRK1	0.60094844
57	STK38L	0.59450197
58	TNK2	0.58574533
59	CAMKK2	0.56289698
60	PRKCG	0.55078437
61	MET	0.54224972
62	PBK	0.52182147
63	RPS6KA6	0.51882090
64	MAP2K2	0.50041035
65	PIK3CA	0.48615301
66	BCKDK	0.46576471
67	RPS6KA5	0.45851487
68	STK3	0.42275849
69	MAP2K1	0.39822292
70	FLT3	0.39359179
71	PASK	0.38872345
72	CSNK1A1	0.37944153
73	IRAK4	0.35944778
74	ERBB2	0.35488947
75	PRKAA2	0.34013219
76	LCK	0.33626001
77	MAP3K7	0.33198878
78	PRKACA	0.33015090
79	LYN	0.32791789
80	STK11	0.32708283
81	PKN1	0.32135172
82	PRKCA	0.31471402
83	MARK1	0.31437081
84	BTK	0.28903729
85	CAMK2A	0.27871678
86	MAP2K7	0.27856372
87	PRKAA1	0.25583343
88	SGK2	0.24964947
89	FER	0.24709643
90	MAPK11	0.23085793
91	CAMK1	0.22998420
92	WEE1	0.22634563
93	PIM1	0.22421339
94	PRKCZ	0.22114653
95	EPHB2	0.21592714
96	CSF1R	0.21448225
97	IGF1R	0.21106194
98	CHEK2	0.20265989
99	TRPM7	0.19961448
100	NEK2	0.19411311

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Linoleic acid metabolism_Homo sapiens_hsa00591	2.95892537
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.92979173
3	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.89825434
4	Phototransduction_Homo sapiens_hsa04744	2.88158730
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.57724300
6	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.52115688
7	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.51657052
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.41685569
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.37742256
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.32243665
11	Caffeine metabolism_Homo sapiens_hsa00232	2.23856138
12	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.06853150
13	Selenocompound metabolism_Homo sapiens_hsa00450	2.04573308
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.00687877
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.95547829
16	Ether lipid metabolism_Homo sapiens_hsa00565	1.87680028
17	Homologous recombination_Homo sapiens_hsa03440	1.85713728
18	Oxidative phosphorylation_Homo sapiens_hsa00190	1.80429340
19	Butanoate metabolism_Homo sapiens_hsa00650	1.67264785
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.65080427
21	Primary immunodeficiency_Homo sapiens_hsa05340	1.56626643
22	ABC transporters_Homo sapiens_hsa02010	1.52519971
23	Sulfur metabolism_Homo sapiens_hsa00920	1.51136958
24	Sulfur relay system_Homo sapiens_hsa04122	1.42975631
25	Taste transduction_Homo sapiens_hsa04742	1.39462861
26	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.39221110
27	RNA polymerase_Homo sapiens_hsa03020	1.39206410
28	Chemical carcinogenesis_Homo sapiens_hsa05204	1.38221752
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.35016144
30	Nicotine addiction_Homo sapiens_hsa05033	1.34845689
31	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.34220264
32	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.29469451
33	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.26211888
34	Basal transcription factors_Homo sapiens_hsa03022	1.20885266
35	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.18850996
36	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.16915852
37	Parkinsons disease_Homo sapiens_hsa05012	1.11548173
38	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.10155034
39	Retinol metabolism_Homo sapiens_hsa00830	1.10055215
40	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.07967989
41	RNA degradation_Homo sapiens_hsa03018	1.06243161
42	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.05333308
43	Asthma_Homo sapiens_hsa05310	1.04403986
44	Glycerolipid metabolism_Homo sapiens_hsa00561	1.03621740
45	Graft-versus-host disease_Homo sapiens_hsa05332	1.02134654
46	Olfactory transduction_Homo sapiens_hsa04740	0.99817142
47	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.99553998
48	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.98720175
49	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.97304161
50	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.95193613
51	Histidine metabolism_Homo sapiens_hsa00340	0.93056550
52	One carbon pool by folate_Homo sapiens_hsa00670	0.92475310
53	Fat digestion and absorption_Homo sapiens_hsa04975	0.91946410
54	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.91692305
55	Peroxisome_Homo sapiens_hsa04146	0.91435951
56	Allograft rejection_Homo sapiens_hsa05330	0.90050978
57	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.88924252
58	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.88346744
59	Morphine addiction_Homo sapiens_hsa05032	0.84529672
60	Protein export_Homo sapiens_hsa03060	0.81685644
61	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.80524936
62	Type I diabetes mellitus_Homo sapiens_hsa04940	0.79982643
63	Huntingtons disease_Homo sapiens_hsa05016	0.76287336
64	Serotonergic synapse_Homo sapiens_hsa04726	0.76268949
65	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.74739648
66	Mineral absorption_Homo sapiens_hsa04978	0.74259881
67	Alzheimers disease_Homo sapiens_hsa05010	0.71923531
68	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.69966565
69	Basal cell carcinoma_Homo sapiens_hsa05217	0.63969885
70	Ribosome_Homo sapiens_hsa03010	0.62495928
71	Regulation of autophagy_Homo sapiens_hsa04140	0.60313191
72	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.60145481
73	Collecting duct acid secretion_Homo sapiens_hsa04966	0.59297392
74	Purine metabolism_Homo sapiens_hsa00230	0.59162146
75	Calcium signaling pathway_Homo sapiens_hsa04020	0.57546221
76	Pyrimidine metabolism_Homo sapiens_hsa00240	0.54675778
77	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.54410228
78	Metabolic pathways_Homo sapiens_hsa01100	0.53649811
79	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.53214082
80	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.52922648
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.52639511
82	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.52225591
83	Insulin secretion_Homo sapiens_hsa04911	0.50566815
84	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.49217963
85	Glutamatergic synapse_Homo sapiens_hsa04724	0.47847421
86	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.46958621
87	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.41996781
88	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.41900440
89	Circadian entrainment_Homo sapiens_hsa04713	0.41505212
90	Salivary secretion_Homo sapiens_hsa04970	0.37347812
91	Circadian rhythm_Homo sapiens_hsa04710	0.35711259
92	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.34610716
93	Long-term depression_Homo sapiens_hsa04730	0.33821917
94	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.33496857
95	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.30920975
96	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.29678151
97	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.28769478
98	Cardiac muscle contraction_Homo sapiens_hsa04260	0.28112733
99	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.27690267
100	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.27167661

SH2D3A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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