SH2D4A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular visceral epithelial cell development (GO:0072015)7.13720017
2regulation of DNA methylation (GO:0044030)6.42039867
3glomerular epithelial cell development (GO:0072310)6.28182607
4regulation of female gonad development (GO:2000194)6.06364712
5regulation of acrosome reaction (GO:0060046)5.84067699
6bundle of His cell to Purkinje myocyte communication (GO:0086069)5.79669637
7glomerular basement membrane development (GO:0032836)5.38117236
8meiotic cell cycle (GO:0051321)5.22644584
9regulation of meiosis I (GO:0060631)4.99131020
10surfactant homeostasis (GO:0043129)4.82023585
11mitotic metaphase plate congression (GO:0007080)4.73496623
12intestinal cholesterol absorption (GO:0030299)4.62414915
13retinal cone cell development (GO:0046549)4.60889095
14valine metabolic process (GO:0006573)4.55691570
15piRNA metabolic process (GO:0034587)4.49168827
16mitotic chromosome condensation (GO:0007076)4.45925332
17multicellular organism reproduction (GO:0032504)4.42412574
18lysine metabolic process (GO:0006553)4.32230808
19lysine catabolic process (GO:0006554)4.32230808
20protein localization to kinetochore (GO:0034501)4.29177842
21chemical homeostasis within a tissue (GO:0048875)4.15219205
22desmosome organization (GO:0002934)4.06967965
23protein localization to chromosome, centromeric region (GO:0071459)4.05898131
24oocyte development (GO:0048599)4.04246237
25female gamete generation (GO:0007292)4.03568891
26positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.00636528
27positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.00636528
28positive regulation of mitotic sister chromatid separation (GO:1901970)4.00636528
29establishment of chromosome localization (GO:0051303)3.94912557
30glomerulus development (GO:0032835)3.92872130
31positive regulation of histone H3-K4 methylation (GO:0051571)3.91960363
32cysteine metabolic process (GO:0006534)3.88906034
33negative regulation of reproductive process (GO:2000242)3.86296491
34regulation of spindle organization (GO:0090224)3.81257944
35positive regulation of gastrulation (GO:2000543)3.76415909
36positive regulation of chromosome segregation (GO:0051984)3.73088188
37metaphase plate congression (GO:0051310)3.72813363
38regulation of cell maturation (GO:1903429)3.62924641
39intestinal absorption (GO:0050892)3.59975361
40regulation of steroid hormone secretion (GO:2000831)3.56425129
41protein autoprocessing (GO:0016540)3.52083149
42citrulline biosynthetic process (GO:0019240)3.51849701
43regulation of steroid hormone biosynthetic process (GO:0090030)3.50457524
44digestion (GO:0007586)3.44411280
45peptide catabolic process (GO:0043171)3.41430863
46homocysteine metabolic process (GO:0050667)3.39951513
47sphingosine metabolic process (GO:0006670)3.39847504
48DNA methylation involved in gamete generation (GO:0043046)3.39498942
49sulfur amino acid catabolic process (GO:0000098)3.38474103
50sphingoid metabolic process (GO:0046519)3.36242945
51paraxial mesoderm development (GO:0048339)3.34975897
52branched-chain amino acid catabolic process (GO:0009083)3.31308775
53binding of sperm to zona pellucida (GO:0007339)3.27734029
54regulation of histone H3-K9 methylation (GO:0051570)3.27270894
55diol metabolic process (GO:0034311)3.24774189
56regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.23725982
57interferon-gamma secretion (GO:0072643)3.18631996
58UDP-N-acetylglucosamine metabolic process (GO:0006047)3.17507362
59branched-chain amino acid metabolic process (GO:0009081)3.15975164
60hemidesmosome assembly (GO:0031581)3.15679131
61type B pancreatic cell proliferation (GO:0044342)3.13133576
62negative regulation of hormone metabolic process (GO:0032351)3.12643635
63one-carbon compound transport (GO:0019755)3.11381338
64regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.11303089
65regulation of meiosis (GO:0040020)3.06839739
66regulation of phospholipase A2 activity (GO:0032429)3.05180002
67reproduction (GO:0000003)3.03616610
68regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.02278701
69centriole replication (GO:0007099)3.00516820
70regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.99945719
71transcytosis (GO:0045056)2.98406292
72ethanol metabolic process (GO:0006067)2.97036311
73regulation of mitotic spindle organization (GO:0060236)2.89450156
74heme biosynthetic process (GO:0006783)2.89283518
75gene silencing by RNA (GO:0031047)2.88374763
76response to nitrosative stress (GO:0051409)2.87932982
77exocrine pancreas development (GO:0031017)2.87563718
78drug transmembrane transport (GO:0006855)2.86390601
79protein retention in ER lumen (GO:0006621)2.84613480
80pyrimidine-containing compound transmembrane transport (GO:0072531)2.82582216
81negative regulation of hormone biosynthetic process (GO:0032353)2.81447834
82amino-acid betaine metabolic process (GO:0006577)2.81167859
83fatty acid beta-oxidation (GO:0006635)2.80164954
84maintenance of gastrointestinal epithelium (GO:0030277)2.79911861
85glycine transport (GO:0015816)2.79326522
86glutathione derivative metabolic process (GO:1901685)2.79143129
87glutathione derivative biosynthetic process (GO:1901687)2.79143129
88primitive streak formation (GO:0090009)2.77984863
89xenobiotic catabolic process (GO:0042178)2.77671978
90protein kinase C signaling (GO:0070528)2.77640090
91carnitine metabolic process (GO:0009437)2.77554217
92positive regulation of hormone biosynthetic process (GO:0046886)2.76894698
93lung vasculature development (GO:0060426)2.75600913
94endoderm development (GO:0007492)2.75150960
95positive regulation of reproductive process (GO:2000243)2.74862676
96positive regulation of DNA-dependent DNA replication (GO:2000105)2.74820014
97negative regulation of histone methylation (GO:0031061)2.74421196
98fertilization (GO:0009566)2.73312399
99ethanol oxidation (GO:0006069)2.71439601
100maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.68709856
101synaptonemal complex assembly (GO:0007130)2.67068272
102tryptophan metabolic process (GO:0006568)2.65663309
103histone-serine phosphorylation (GO:0035404)2.65644272
104nucleotide-sugar biosynthetic process (GO:0009226)2.63417979
105indole-containing compound catabolic process (GO:0042436)2.62347239
106indolalkylamine catabolic process (GO:0046218)2.62347239
107tryptophan catabolic process (GO:0006569)2.62347239
108regulation of hormone biosynthetic process (GO:0046885)2.61981490
109heme metabolic process (GO:0042168)2.60480671
110DNA replication checkpoint (GO:0000076)2.60317498
111L-phenylalanine metabolic process (GO:0006558)2.59942963
112erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.59942963
113protein localization to chromosome (GO:0034502)2.59862704
114protoporphyrinogen IX biosynthetic process (GO:0006782)2.57612384
115intestinal epithelial cell development (GO:0060576)2.57537257
116epithelial cell-cell adhesion (GO:0090136)2.57183830
117fatty acid oxidation (GO:0019395)2.56938255
118aspartate family amino acid catabolic process (GO:0009068)2.56905078
119single fertilization (GO:0007338)2.55917354
120attachment of spindle microtubules to kinetochore (GO:0008608)2.55701340
121regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.54575748
122regulation of meiotic cell cycle (GO:0051445)2.52997604
123short-chain fatty acid metabolic process (GO:0046459)2.52326975
124lipid oxidation (GO:0034440)2.51346836
125detection of bacterium (GO:0016045)2.51202101
126skin morphogenesis (GO:0043589)2.50892886
127positive regulation of cytokinesis (GO:0032467)2.49895889
128citrulline metabolic process (GO:0000052)2.49329057
129positive regulation of uterine smooth muscle contraction (GO:0070474)2.47803990
130synaptonemal complex organization (GO:0070193)2.46785962
131regulation of reproductive process (GO:2000241)2.46373963
132negative regulation of digestive system process (GO:0060457)2.46355772
133primary alcohol catabolic process (GO:0034310)2.45014056
134positive regulation of hormone metabolic process (GO:0032352)2.44905064
135establishment or maintenance of bipolar cell polarity (GO:0061245)2.44830408
136establishment or maintenance of apical/basal cell polarity (GO:0035088)2.44830408
137hippo signaling (GO:0035329)2.44822202
138oogenesis (GO:0048477)2.44538822
139hormone catabolic process (GO:0042447)2.44493228
140cellular ketone body metabolic process (GO:0046950)2.44398032
141regulation of water loss via skin (GO:0033561)2.43961367
142regulation of spindle checkpoint (GO:0090231)2.43860072
143protein carboxylation (GO:0018214)2.43509310
144peptidyl-glutamic acid carboxylation (GO:0017187)2.43509310
145biotin metabolic process (GO:0006768)2.43302024
146regulation of glomerular filtration (GO:0003093)2.43022657
147phospholipid scrambling (GO:0017121)2.42789716
148triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.42664178
149aromatic amino acid family catabolic process (GO:0009074)2.42662900
150drug transport (GO:0015893)2.42645396
151calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.42336446
152regulation of bile acid biosynthetic process (GO:0070857)2.41896519
153pericardium development (GO:0060039)2.41649345
154ventricular cardiac muscle cell action potential (GO:0086005)2.41411799
155endocardial cushion development (GO:0003197)2.41367292
156protoporphyrinogen IX metabolic process (GO:0046501)2.40970874
157CENP-A containing nucleosome assembly (GO:0034080)2.40903700
158O-glycan processing (GO:0016266)2.40878197
159angiotensin maturation (GO:0002003)2.40193721
160fatty acid catabolic process (GO:0009062)2.39328671
161detection of other organism (GO:0098543)2.39073911
162spindle assembly involved in mitosis (GO:0090307)2.39011631
163drug catabolic process (GO:0042737)2.38924416
164ventricular cardiac muscle cell development (GO:0055015)2.38869227
165regulation of RNA export from nucleus (GO:0046831)2.38812736
166chromosome condensation (GO:0030261)2.38598351
167cell adhesion mediated by integrin (GO:0033627)2.38461025
168renal system process involved in regulation of blood volume (GO:0001977)2.38431444
169erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.38128422
170L-phenylalanine catabolic process (GO:0006559)2.38128422
171fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.36640896
172regulation of skeletal muscle contraction (GO:0014819)2.36479593
173embryo implantation (GO:0007566)2.35656686
174nuclear pore organization (GO:0006999)2.35597748
175hepatocyte apoptotic process (GO:0097284)2.31368130
176regulation of alkaline phosphatase activity (GO:0010692)2.30682146
177reverse cholesterol transport (GO:0043691)2.29667927
178regulation of double-strand break repair via homologous recombination (GO:0010569)2.29575806
179mitochondrial calcium ion transport (GO:0006851)2.29359643
180bile acid and bile salt transport (GO:0015721)2.29228667
181chromosome organization involved in meiosis (GO:0070192)2.29165841
182positive regulation of cellular amine metabolic process (GO:0033240)2.29062454
183flavonoid metabolic process (GO:0009812)2.29017438
184copper ion transport (GO:0006825)2.28933321
185negative regulation of stem cell proliferation (GO:2000647)2.28856200
186sperm-egg recognition (GO:0035036)2.28466344
187nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.27897323
188digestive system process (GO:0022600)2.27791968
189regulation of natural killer cell differentiation (GO:0032823)2.27671013
190excretion (GO:0007588)2.27655627
191relaxation of smooth muscle (GO:0044557)2.27249892
192smooth muscle tissue development (GO:0048745)2.26764535
193centrosome duplication (GO:0051298)2.26719557
194centriole assembly (GO:0098534)2.26558540
195endothelial cell morphogenesis (GO:0001886)2.26380129
196regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.25732759

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.64065100
2EZH2_22144423_ChIP-Seq_EOC_Human5.95130852
3* ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.27110594
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.84290338
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.27906044
6E2F7_22180533_ChIP-Seq_HELA_Human4.22602246
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.83511801
8PPARA_22158963_ChIP-Seq_LIVER_Mouse3.80590109
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.78605299
10RXR_22158963_ChIP-Seq_LIVER_Mouse3.78543687
11FOXM1_23109430_ChIP-Seq_U2OS_Human3.54043458
12GATA1_22025678_ChIP-Seq_K562_Human3.49657945
13STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse3.10193115
14LXR_22158963_ChIP-Seq_LIVER_Mouse3.09782760
15ESR1_21235772_ChIP-Seq_MCF-7_Human3.08368278
16EGR1_23403033_ChIP-Seq_LIVER_Mouse3.02889274
17GATA4_25053715_ChIP-Seq_YYC3_Human2.95669469
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90571259
19* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.87904498
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.64002613
21CDX2_20551321_ChIP-Seq_CACO-2_Human2.57320569
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.53535753
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.48975651
24RARG_19884340_ChIP-ChIP_MEFs_Mouse2.45499867
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.37848413
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.34314838
27SOX2_20726797_ChIP-Seq_SW620_Human2.29811438
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.27435642
29* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.27114991
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.21384918
31TRIM28_21343339_ChIP-Seq_HEK293_Human2.17338924
32ESR1_20079471_ChIP-ChIP_T-47D_Human2.11695780
33ESR1_15608294_ChIP-ChIP_MCF-7_Human2.07421581
34ESR2_21235772_ChIP-Seq_MCF-7_Human2.07097308
35FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.93522817
36* GATA6_25053715_ChIP-Seq_YYC3_Human1.92435108
37* BRD4_25478319_ChIP-Seq_HGPS_Human1.87670944
38KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.86320296
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.86320296
40KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.86320296
41* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.83138159
42CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.82681861
43IRF8_22096565_ChIP-ChIP_GC-B_Human1.76836244
44CLOCK_20551151_ChIP-Seq_293T_Human1.74195175
45FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.71752506
46* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.71398866
47* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.71398866
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70707675
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.66598205
50TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64468505
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59591107
52HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.57829638
53FOXO3_23340844_ChIP-Seq_DLD1_Human1.56498248
54SALL4_18804426_ChIP-ChIP_XEN_Mouse1.52392105
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52139542
56P63_26484246_Chip-Seq_KERATINOCYTES_Human1.50332557
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.50261417
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.44325771
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43976724
60AR_21909140_ChIP-Seq_LNCAP_Human1.42478797
61* GATA3_24758297_ChIP-Seq_MCF-7_Human1.40483260
62* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39528673
63E2F4_17652178_ChIP-ChIP_JURKAT_Human1.36662856
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.33531127
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29362925
66ELF5_23300383_ChIP-Seq_T47D_Human1.28649487
67TCF4_18268006_ChIP-ChIP_LS174T_Human1.28248340
68TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.28098977
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.27513169
70* FOXA2_19822575_ChIP-Seq_HepG2_Human1.27297623
71TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26858989
72PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22773462
73* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.22446488
74CJUN_26792858_Chip-Seq_BT549_Human1.22046197
75SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21204393
76Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20744546
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19104967
78MYC_18555785_ChIP-Seq_MESCs_Mouse1.17346496
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.17250447
80* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16290077
81KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.16164508
82* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.15151297
83TP53_18474530_ChIP-ChIP_U2OS_Human1.14554677
84* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.13459086
85CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13300387
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10083283
87TP53_16413492_ChIP-PET_HCT116_Human1.09377521
88EP300_21415370_ChIP-Seq_HL-1_Mouse1.08622856
89* HNF4A_19822575_ChIP-Seq_HepG2_Human1.06292346
90CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06268263
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06058947
92MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.05798558
93NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05768519
94MYC_19079543_ChIP-ChIP_MESCs_Mouse1.05454176
95ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05381672
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05181707
97STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05013935
98HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04953826
99* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04846106
100NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04630043
101CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04484385
102TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04102164
103CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03765993
104GATA2_19941826_ChIP-Seq_K562_Human1.01751095
105EGR1_19032775_ChIP-ChIP_M12_Human0.98600354
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97744249
107RUNX1_27514584_Chip-Seq_MCF-7_Human0.96885993
108EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96545983
109CBP_21632823_ChIP-Seq_H3396_Human0.95911003
110PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95568651
111ATF3_27146783_Chip-Seq_COLON_Human0.95494707
112TBX20_22080862_ChIP-Seq_HEART_Mouse0.95310096
113TBX20_22328084_ChIP-Seq_HEART_Mouse0.95310096
114KLF5_25053715_ChIP-Seq_YYC3_Human0.94831885
115ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93024532
116CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92469751
117NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.91864634
118RACK7_27058665_Chip-Seq_MCF-7_Human0.90376953
119CDX2_22108803_ChIP-Seq_LS180_Human0.88152153
120NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87915681
121NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87915681
122FOXA1_25552417_ChIP-Seq_VCAP_Human0.87445075
123JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87097319
124ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86874504
125AR_20517297_ChIP-Seq_VCAP_Human0.86213230
126POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85975326
127SMAD_19615063_ChIP-ChIP_OVARY_Human0.85713767
128TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85665698
129TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85188615
130AHR_22903824_ChIP-Seq_MCF-7_Human0.83522242
131ELK1_22589737_ChIP-Seq_MCF10A_Human0.83482366
132GATA1_19941827_ChIP-Seq_MEL_Mouse0.83229063
133BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.82339638
134TP63_23658742_ChIP-Seq_EP156T_Human0.82059780
135KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81675247
136ZNF263_19887448_ChIP-Seq_K562_Human0.81296518
137* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.79975990
138E2F1_21310950_ChIP-Seq_MCF-7_Human0.79836520
139FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.79472938
140SOX17_20123909_ChIP-Seq_XEN_Mouse0.77939482
141TP63_19390658_ChIP-ChIP_HaCaT_Human0.77844136
142* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.77680015
143THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.76592144
144JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76333252
145BP1_19119308_ChIP-ChIP_Hs578T_Human0.75959421
146MYC_19030024_ChIP-ChIP_MESCs_Mouse0.75681931
147STAT6_21828071_ChIP-Seq_BEAS2B_Human0.75477936
148GATA4_21415370_ChIP-Seq_HL-1_Mouse0.75301366
149SRF_21415370_ChIP-Seq_HL-1_Mouse0.75255929
150TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.73422019
151* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.72702340

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect5.20699313
2MP0002139_abnormal_hepatobiliary_system4.34739363
3MP0008438_abnormal_cutaneous_collagen3.65663965
4MP0008004_abnormal_stomach_pH3.65379940
5MP0001666_abnormal_nutrient_absorption3.64133109
6MP0003950_abnormal_plasma_membrane3.63041197
7MP0005085_abnormal_gallbladder_physiolo3.57819749
8MP0002138_abnormal_hepatobiliary_system3.37772653
9MP0005365_abnormal_bile_salt3.32968683
10MP0005360_urolithiasis3.08178405
11MP0005083_abnormal_biliary_tract3.06935874
12MP0010030_abnormal_orbit_morphology2.73040400
13MP0005503_abnormal_tendon_morphology2.64961987
14MP0006054_spinal_hemorrhage2.53591952
15MP0005395_other_phenotype2.52050635
16MP0003806_abnormal_nucleotide_metabolis2.50616712
17MP0003693_abnormal_embryo_hatching2.44977092
18MP0003252_abnormal_bile_duct2.31381023
19MP0010234_abnormal_vibrissa_follicle2.22804297
20MP0008789_abnormal_olfactory_epithelium2.20135349
21MP0003941_abnormal_skin_development2.18662449
22MP0001873_stomach_inflammation2.18013296
23MP0008875_abnormal_xenobiotic_pharmacok2.15964957
24MP0004147_increased_porphyrin_level2.15319677
25MP0003656_abnormal_erythrocyte_physiolo2.11539944
26MP0009780_abnormal_chondrocyte_physiolo2.08666927
27MP0004782_abnormal_surfactant_physiolog1.98042962
28MP0005023_abnormal_wound_healing1.97738818
29MP0000537_abnormal_urethra_morphology1.95935279
30MP0004264_abnormal_extraembryonic_tissu1.95428838
31MP0006292_abnormal_olfactory_placode1.95203076
32MP0005332_abnormal_amino_acid1.80801238
33MP0000762_abnormal_tongue_morphology1.80515167
34MP0009643_abnormal_urine_homeostasis1.79186517
35MP0005451_abnormal_body_composition1.77819848
36MP0002254_reproductive_system_inflammat1.71225946
37MP0002796_impaired_skin_barrier1.67608385
38MP0003890_abnormal_embryonic-extraembry1.58653281
39MP0003195_calcinosis1.56912370
40MP0003868_abnormal_feces_composition1.56861028
41MP0003077_abnormal_cell_cycle1.56774128
42MP0005220_abnormal_exocrine_pancreas1.55868080
43MP0000566_synostosis1.53187085
44MP0003186_abnormal_redox_activity1.49686499
45MP0002098_abnormal_vibrissa_morphology1.48158958
46MP0003699_abnormal_female_reproductive1.46780668
47MP0005499_abnormal_olfactory_system1.45677875
48MP0005394_taste/olfaction_phenotype1.45677875
49MP0005257_abnormal_intraocular_pressure1.42891021
50MP0004019_abnormal_vitamin_homeostasis1.40658724
51MP0002234_abnormal_pharynx_morphology1.39871128
52MP0009384_cardiac_valve_regurgitation1.38307323
53MP0003191_abnormal_cellular_cholesterol1.36981935
54MP0008932_abnormal_embryonic_tissue1.36618718
55MP0002136_abnormal_kidney_physiology1.36483173
56MP0010329_abnormal_lipoprotein_level1.35899586
57MP0001664_abnormal_digestion1.35196689
58MP0001730_embryonic_growth_arrest1.31036900
59MP0010094_abnormal_chromosome_stability1.29905201
60MP0003879_abnormal_hair_cell1.29311739
61MP0008057_abnormal_DNA_replication1.28381740
62MP0002132_abnormal_respiratory_system1.26972592
63MP0001756_abnormal_urination1.26783831
64MP0004957_abnormal_blastocyst_morpholog1.26179257
65MP0003111_abnormal_nucleus_morphology1.25905720
66MP0000490_abnormal_crypts_of1.25835254
67MP0001663_abnormal_digestive_system1.24476031
68MP0002160_abnormal_reproductive_system1.23437443
69MP0005636_abnormal_mineral_homeostasis1.22433401
70MP0004272_abnormal_basement_membrane1.22101723
71MP0005084_abnormal_gallbladder_morpholo1.21272792
72MP0000427_abnormal_hair_cycle1.19196112
73MP0005501_abnormal_skin_physiology1.18298556
74MP0004043_abnormal_pH_regulation1.16951883
75MP0000470_abnormal_stomach_morphology1.15533358
76MP0003566_abnormal_cell_adhesion1.14382428
77MP0010352_gastrointestinal_tract_polyps1.14347920
78MP0005623_abnormal_meninges_morphology1.12114555
79MP0005319_abnormal_enzyme/_coenzyme1.09980547
80MP0005410_abnormal_fertilization1.09977786
81MP0010307_abnormal_tumor_latency1.09205750
82MP0010155_abnormal_intestine_physiology1.09158406
83MP0003183_abnormal_peptide_metabolism1.09065531
84MP0009697_abnormal_copulation1.07259645
85MP0009250_abnormal_appendicular_skeleto1.06757732
86MP0005647_abnormal_sex_gland1.06380512
87MP0009764_decreased_sensitivity_to1.06036289
88MP0005508_abnormal_skeleton_morphology1.05895480
89MP0008877_abnormal_DNA_methylation1.05069726
90MP0000678_abnormal_parathyroid_gland1.04675207
91MP0002060_abnormal_skin_morphology1.03997723
92MP0001929_abnormal_gametogenesis1.03789316
93MP0003300_gastrointestinal_ulcer1.03431493
94MP0002233_abnormal_nose_morphology1.02786661
95MP0002118_abnormal_lipid_homeostasis1.02439933
96MP0004084_abnormal_cardiac_muscle1.02262959
97MP0008775_abnormal_heart_ventricle1.01399418
98MP0010368_abnormal_lymphatic_system1.01004639
99MP0003705_abnormal_hypodermis_morpholog1.00372777
100MP0003091_abnormal_cell_migration0.99909064
101MP0002210_abnormal_sex_determination0.99855945
102MP0000609_abnormal_liver_physiology0.99725649
103MP0004233_abnormal_muscle_weight0.99309835
104MP0001216_abnormal_epidermal_layer0.99101858
105MP0008058_abnormal_DNA_repair0.97301055
106MP0009840_abnormal_foam_cell0.97272749
107MP0002896_abnormal_bone_mineralization0.96931642
108MP0004947_skin_inflammation0.96518508
109MP0005381_digestive/alimentary_phenotyp0.95846949
110MP0005076_abnormal_cell_differentiation0.95724141
111MP0000350_abnormal_cell_proliferation0.95017013
112MP0002277_abnormal_respiratory_mucosa0.93506686
113MP0002295_abnormal_pulmonary_circulatio0.92916479
114MP0005408_hypopigmentation0.89684714
115MP0010678_abnormal_skin_adnexa0.89454761
116MP0001243_abnormal_dermal_layer0.89290545
117MP0002161_abnormal_fertility/fecundity0.88138979
118MP0002009_preneoplasia0.88034448
119MP0001346_abnormal_lacrimal_gland0.87653882
120MP0000627_abnormal_mammary_gland0.87160610
121MP0001764_abnormal_homeostasis0.86732820
122MP0001542_abnormal_bone_strength0.86534648
123MP0002163_abnormal_gland_morphology0.86455925
124MP0002108_abnormal_muscle_morphology0.86428287
125MP0001672_abnormal_embryogenesis/_devel0.86363797
126MP0005380_embryogenesis_phenotype0.86363797
127MP0003279_aneurysm0.85979397
128MP0000733_abnormal_muscle_development0.85322560
129MP0000477_abnormal_intestine_morphology0.85281338
130MP0000428_abnormal_craniofacial_morphol0.85160038
131MP0005275_abnormal_skin_tensile0.84889821
132MP0008995_early_reproductive_senescence0.84257062
133MP0002084_abnormal_developmental_patter0.82793797
134MP0000653_abnormal_sex_gland0.81623959
135MP0002166_altered_tumor_susceptibility0.81506029
136MP0001293_anophthalmia0.81188468
137MP0000049_abnormal_middle_ear0.80477785
138MP0000579_abnormal_nail_morphology0.79687506
139MP0003755_abnormal_palate_morphology0.79415590
140MP0002135_abnormal_kidney_morphology0.79400695
141MP0005197_abnormal_uvea_morphology0.77307291
142MP0001879_abnormal_lymphatic_vessel0.77266024
143MP0000383_abnormal_hair_follicle0.74628735
144MP0002877_abnormal_melanocyte_morpholog0.74419292
145MP0001765_abnormal_ion_homeostasis0.73839635
146MP0000377_abnormal_hair_follicle0.73800830
147MP0000538_abnormal_urinary_bladder0.72583928
148MP0003937_abnormal_limbs/digits/tail_de0.72575761
149MP0008469_abnormal_protein_level0.72558733
150MP0003453_abnormal_keratinocyte_physiol0.72448160
151MP0002089_abnormal_postnatal_growth/wei0.71387540
152MP0002006_tumorigenesis0.70783191
153MP0000230_abnormal_systemic_arterial0.69654689
154MP0000467_abnormal_esophagus_morphology0.69629847
155MP0002085_abnormal_embryonic_tissue0.69021998
156MP0000516_abnormal_urinary_system0.68426058
157MP0005367_renal/urinary_system_phenotyp0.68426058
158MP0001881_abnormal_mammary_gland0.67821903
159MP0000613_abnormal_salivary_gland0.66104160
160MP0004215_abnormal_myocardial_fiber0.65796287
161MP0003943_abnormal_hepatobiliary_system0.65395076
162MP0004185_abnormal_adipocyte_glucose0.65243166
163MP0005165_increased_susceptibility_to0.65130559
164MP0001958_emphysema0.64525116
165MP0001845_abnormal_inflammatory_respons0.62894883
166MP0001661_extended_life_span0.61893949
167MP0000462_abnormal_digestive_system0.60897614
168MP0010771_integument_phenotype0.60654394
169MP0001191_abnormal_skin_condition0.59895592

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)5.30358335
2Ankle contracture (HP:0006466)4.81472592
3Premature rupture of membranes (HP:0001788)4.66128745
4Protrusio acetabuli (HP:0003179)4.24272454
5Focal segmental glomerulosclerosis (HP:0000097)4.01042982
6Gout (HP:0001997)3.94264556
7Glomerulosclerosis (HP:0000096)3.87380791
8Lip pit (HP:0100267)3.85868663
9Mesangial abnormality (HP:0001966)3.75238059
10Onycholysis (HP:0001806)3.71936678
11Hyperactive renin-angiotensin system (HP:0000841)3.58451458
12Intrahepatic cholestasis (HP:0001406)3.45423927
13Male infertility (HP:0003251)3.40913245
14Shallow orbits (HP:0000586)3.19724988
15Spinal cord compression (HP:0002176)3.19023354
16Wrist flexion contracture (HP:0001239)3.07345893
17Abnormality of the heme biosynthetic pathway (HP:0010472)3.06387830
18Ileus (HP:0002595)3.05168521
19Osteomalacia (HP:0002749)3.03801883
20Abnormality of fatty-acid metabolism (HP:0004359)2.99835799
21Hypoalbuminemia (HP:0003073)2.98288915
22Abnormal albumin level (HP:0012116)2.98288915
23Abnormality of chloride homeostasis (HP:0011422)2.97345038
24Facial hemangioma (HP:0000329)2.91698498
25Abnormality of monocarboxylic acid metabolism (HP:0010996)2.89033630
26Abnormality of glutamine family amino acid metabolism (HP:0010902)2.88000868
27Supernumerary spleens (HP:0009799)2.87221617
28Tubulointerstitial fibrosis (HP:0005576)2.87074240
29Abnormality of purine metabolism (HP:0004352)2.84240621
30Microglossia (HP:0000171)2.83822000
31Increased purine levels (HP:0004368)2.81651121
32Hyperuricemia (HP:0002149)2.81651121
33Hypophosphatemic rickets (HP:0004912)2.79567504
34Esophageal varix (HP:0002040)2.77876835
35Metaphyseal dysplasia (HP:0100255)2.77608559
36Nephritis (HP:0000123)2.76682186
37Elbow flexion contracture (HP:0002987)2.75988698
38Abnormal tarsal ossification (HP:0008369)2.75934665
39Aortic aneurysm (HP:0004942)2.75075308
40Hyperammonemia (HP:0001987)2.73546326
41Nausea (HP:0002018)2.73496718
42Abdominal situs inversus (HP:0003363)2.70751984
43Abnormality of abdominal situs (HP:0011620)2.70751984
44Aplasia of the musculature (HP:0100854)2.70220746
45Vascular calcification (HP:0004934)2.65517710
46Vascular tortuosity (HP:0004948)2.65447178
47Abnormality of proline metabolism (HP:0010907)2.60577533
48Hydroxyprolinuria (HP:0003080)2.60577533
49Hypokinesia (HP:0002375)2.56216989
50Renal cortical cysts (HP:0000803)2.55805641
51Abnormal gallbladder physiology (HP:0012438)2.55189742
52Cholecystitis (HP:0001082)2.55189742
53Fat malabsorption (HP:0002630)2.53536609
54Rectal prolapse (HP:0002035)2.52826590
55Proximal tubulopathy (HP:0000114)2.51547371
56Chromsome breakage (HP:0040012)2.51238329
57Tubular atrophy (HP:0000092)2.49862919
58Interstitial pulmonary disease (HP:0006530)2.48721308
59Wormian bones (HP:0002645)2.46851400
60Aortic dissection (HP:0002647)2.45174602
61Cervical subluxation (HP:0003308)2.43305696
62Abnormality of carpal bone ossification (HP:0006257)2.43108816
63Follicular hyperkeratosis (HP:0007502)2.42563787
64Woolly hair (HP:0002224)2.42516443
65Ventricular tachycardia (HP:0004756)2.42056345
66Soft skin (HP:0000977)2.41611275
67Hyperglycinuria (HP:0003108)2.39822766
68Abnormality of the renal cortex (HP:0011035)2.37888331
69Hepatocellular carcinoma (HP:0001402)2.37362698
70Generalized aminoaciduria (HP:0002909)2.36642001
71Hypoglycemic coma (HP:0001325)2.35884458
72Median cleft lip (HP:0000161)2.34193464
73Cardiovascular calcification (HP:0011915)2.32488451
74Abnormality of nucleobase metabolism (HP:0010932)2.31379060
75Neonatal short-limb short stature (HP:0008921)2.29579858
76Infertility (HP:0000789)2.29428890
77Abnormality of the phalanges of the hallux (HP:0010057)2.29148317
78Malnutrition (HP:0004395)2.29039505
79Abnormality of the intrinsic pathway (HP:0010989)2.28627138
80Palpitations (HP:0001962)2.28449038
81Stage 5 chronic kidney disease (HP:0003774)2.27484073
82Abnormality of the acetabulum (HP:0003170)2.27408430
83Abnormality of aspartate family amino acid metabolism (HP:0010899)2.26591729
84Striae distensae (HP:0001065)2.25280467
85Entropion (HP:0000621)2.24282177
86Osteolytic defects of the hand bones (HP:0009699)2.23466986
87Osteolytic defects of the phalanges of the hand (HP:0009771)2.23466986
88Abnormality of dicarboxylic acid metabolism (HP:0010995)2.23261640
89Dicarboxylic aciduria (HP:0003215)2.23261640
90Respiratory distress (HP:0002098)2.22619962
91Reduced subcutaneous adipose tissue (HP:0003758)2.22199469
92Conjugated hyperbilirubinemia (HP:0002908)2.22059892
93Renal salt wasting (HP:0000127)2.21813051
94Spinal rigidity (HP:0003306)2.21125589
95Abnormality of sulfur amino acid metabolism (HP:0004339)2.20556321
96Knee flexion contracture (HP:0006380)2.20384874
97Abnormal spermatogenesis (HP:0008669)2.20277748
98Potter facies (HP:0002009)2.19740782
99Facial shape deformation (HP:0011334)2.19740782
100Atrophic scars (HP:0001075)2.19410892
101Hyperbilirubinemia (HP:0002904)2.17775811
102Posterior subcapsular cataract (HP:0007787)2.17168866
103Micronodular cirrhosis (HP:0001413)2.17099411
104Impulsivity (HP:0100710)2.17062949
105Metabolic acidosis (HP:0001942)2.16858003
106Abnormal pancreas size (HP:0012094)2.13886202
107Glycosuria (HP:0003076)2.13599533
108Abnormality of urine glucose concentration (HP:0011016)2.13599533
109Capillary hemangiomas (HP:0005306)2.13334169
110Steatorrhea (HP:0002570)2.12807221
111Chromosomal breakage induced by crosslinking agents (HP:0003221)2.11711416
112Subcapsular cataract (HP:0000523)2.11258180
113Oligodactyly (hands) (HP:0001180)2.11069363
114Hypobetalipoproteinemia (HP:0003563)2.09291881
115Deep venous thrombosis (HP:0002625)2.08166624
116Arterial tortuosity (HP:0005116)2.08063740
117Acanthocytosis (HP:0001927)2.07626476
118Femoral bowing (HP:0002980)2.07277723
119Abnormal foot bone ossification (HP:0010675)2.07231547
120Sparse eyelashes (HP:0000653)2.07037262
121Tubulointerstitial nephritis (HP:0001970)2.06362085
122Bladder diverticulum (HP:0000015)2.05502720
123Ketoacidosis (HP:0001993)2.04802587
124Tibial bowing (HP:0002982)2.03802494
125Ketosis (HP:0001946)2.02493000
126Rough bone trabeculation (HP:0100670)2.02024678
127Abnormality of transition element cation homeostasis (HP:0011030)2.01468247
128Natal tooth (HP:0000695)2.01225730
129Flat acetabular roof (HP:0003180)2.01217495
130Fragile skin (HP:0001030)2.00825445
131Glomerulonephritis (HP:0000099)2.00571701
132Poikilocytosis (HP:0004447)2.00096873
133Anterior segment dysgenesis (HP:0007700)1.99621016
134Hypoplasia of the fovea (HP:0007750)1.99043315
135Aplasia/Hypoplasia of the fovea (HP:0008060)1.99043315
136Stillbirth (HP:0003826)1.98194471
137Hyperaldosteronism (HP:0000859)1.97487868
138Abnormality of aromatic amino acid family metabolism (HP:0004338)1.97459247
139Hypoproteinemia (HP:0003075)1.97357422
140Polycythemia (HP:0001901)1.97032179
141Dehydration (HP:0001944)1.96911390
142Cupped ribs (HP:0000887)1.96885492
143Abdominal distention (HP:0003270)1.96084554
144Papillary thyroid carcinoma (HP:0002895)1.94767515
145Abnormality of renal excretion (HP:0011036)1.94700763
146Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.94167025
147Premature ovarian failure (HP:0008209)1.94074207
148Pili torti (HP:0003777)1.93900160
149Corneal erosion (HP:0200020)1.92379078
150Plantar hyperkeratosis (HP:0007556)1.92017126
151Conjunctival hamartoma (HP:0100780)1.91809988
152Hypolipoproteinemia (HP:0010981)1.90633969
153Mitral stenosis (HP:0001718)1.90065422
154Azoospermia (HP:0000027)1.89728936
155Abnormality of glycine metabolism (HP:0010895)1.88691859
156Abnormality of serine family amino acid metabolism (HP:0010894)1.88691859
157Abnormal hand bone ossification (HP:0010660)1.88478080
158Trismus (HP:0000211)1.88294627
159Abnormality of methionine metabolism (HP:0010901)1.87983565
160Tubulointerstitial abnormality (HP:0001969)1.87715477
161Reduced antithrombin III activity (HP:0001976)1.87588814
162Aortic valve stenosis (HP:0001650)1.86887242
163Abnormal ossification of hand bones (HP:0005921)1.86592290
164Increased connective tissue (HP:0009025)1.86520575
165Xanthomatosis (HP:0000991)1.84984505
166Gonadotropin excess (HP:0000837)1.84578182
167Abnormal number of erythroid precursors (HP:0012131)1.83000247
168Germ cell neoplasia (HP:0100728)1.82633691
169Blue sclerae (HP:0000592)1.81998772
170Autoimmune thrombocytopenia (HP:0001973)1.81530742
171Pustule (HP:0200039)1.80448947
172Lethargy (HP:0001254)1.80448174
173Abnormality of dentin (HP:0010299)1.79932060
174Hypoalphalipoproteinemia (HP:0003233)1.78471550
175Abnormality of the distal phalanges of the toes (HP:0010182)1.78243354
176Facial cleft (HP:0002006)1.76475905
177Congenital ichthyosiform erythroderma (HP:0007431)1.73769984
178Vertebral compression fractures (HP:0002953)1.73468272
179Sensory axonal neuropathy (HP:0003390)1.72036395
180Abnormality of Sharpey fibers (HP:0100685)1.71103710
181Rickets (HP:0002748)1.68617178
182Abnormal trabecular bone morphology (HP:0100671)1.68330877
183Short tibia (HP:0005736)1.66292320
184Hip contracture (HP:0003273)1.65539603
185Short nail (HP:0001799)1.64788925
186Sparse lateral eyebrow (HP:0005338)1.64286415
187Coronal craniosynostosis (HP:0004440)1.64195919
188Cone-rod dystrophy (HP:0000548)1.63352954

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.85058604
2ARAF3.57083534
3MST1R3.41557717
4MAP3K93.41057592
5FRK3.41032810
6BCKDK2.95967192
7STK242.82796740
8STK38L2.77763890
9MAP3K132.73550120
10TTK2.67264128
11EPHA22.60314504
12MYLK2.49220231
13EPHB22.49084798
14LMTK22.25247669
15CDK122.20225952
16PBK2.18041131
17MAP3K32.13251969
18NEK62.03109218
19STK31.98323781
20LATS11.89023129
21LATS21.87404074
22TGFBR21.80013778
23BRAF1.72650694
24CDK91.70129439
25NME11.69563061
26BUB11.68359332
27AURKA1.67617993
28WNK41.66766477
29MOS1.62233376
30NUAK11.60579809
31MAP2K21.55912925
32TIE11.53418423
33PTK61.51356479
34MELK1.48811111
35MAP3K141.45209892
36FER1.44429166
37MAP2K31.40467628
38CDC71.40372303
39ERN11.38335493
40PIK3CA1.37858366
41PKN21.34372036
42CDK71.33912856
43OXSR11.32200916
44NEK91.31076815
45PDGFRA1.26521953
46GRK11.23416836
47NME21.23017363
48PLK11.19735411
49MAP3K121.18754967
50CDK81.16147589
51PAK41.15611796
52TBK11.15398592
53ERBB41.11714957
54BRSK21.10431395
55FLT31.10363759
56STK101.10194287
57PIK3CG1.06487628
58SIK11.05148549
59IRAK31.04841988
60FGFR41.04299168
61BRSK11.03821105
62TAOK21.03596380
63LRRK21.03194510
64STK391.01179123
65TRPM70.99940888
66MAP3K80.99118357
67PRKG20.98182078
68PAK20.98110792
69OBSCN0.96358279
70RPS6KB20.95006017
71STK380.94440411
72NEK20.93374032
73INSRR0.93261038
74RAF10.92801327
75TGFBR10.92423715
76MET0.88979069
77EPHA30.88099201
78TRIB30.88076157
79PDK20.87539781
80DDR20.86847987
81MTOR0.86326847
82TYK20.86196183
83NEK10.85365449
84LIMK10.81670929
85MAP2K10.81553921
86CHEK20.80671099
87MAP2K60.79923934
88ERBB30.79172085
89ZAK0.77896939
90PIM20.77666979
91MAPKAPK30.74577354
92CHEK10.73961455
93PLK30.73867649
94DMPK0.73689462
95ILK0.73191065
96TESK10.71922301
97JAK30.71772192
98TAOK30.70925625
99RIPK10.67136138
100EIF2AK20.66586648
101TTN0.66155492
102IKBKE0.62574873
103KSR20.61894591
104CHUK0.61421317
105ZAP700.61264080
106PDK30.59963101
107PDK40.59963101
108ICK0.59411055
109MAP3K20.59344537
110RPS6KA40.59076610
111WNK30.58759637
112PAK10.58605874
113PRKAA20.58467525
114MAP3K70.58005344
115WNK10.56145886
116EIF2AK30.55841182
117ERBB20.54538864
118FGFR30.54531209
119BMPR1B0.53899983
120MAP3K110.53127317
121IKBKB0.51715901
122TRIM280.51699518
123PLK40.50675868
124JAK20.44690084
125DAPK20.43176621
126MAPK110.41800657
127AKT20.40014137
128MATK0.39927196
129AKT30.39454896
130CSNK1E0.39209145
131STK160.38948608
132PRKCI0.38467042
133CDK20.37801149
134ROCK10.36631537
135SRPK10.35816204
136MAP3K50.35174356
137SGK20.34781603
138MAPKAPK20.34644476
139TNIK0.34153692
140PTK20.34097345
141BCR0.33607317
142ABL20.33511053
143* AURKB0.33247307
144CDK10.33091363
145EIF2AK10.32920221
146ATM0.32327692
147YES10.31737846
148EPHB10.31418902
149SIK30.31280642
150VRK20.31212918
151EEF2K0.30829335
152CAMK2G0.27656798

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030223.04060368
2Sulfur metabolism_Homo sapiens_hsa009202.82076782
3Cell cycle_Homo sapiens_hsa041102.80253084
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.74174401
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.66189372
6Fatty acid degradation_Homo sapiens_hsa000712.66125082
7Fat digestion and absorption_Homo sapiens_hsa049752.54121687
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.42733265
9Propanoate metabolism_Homo sapiens_hsa006402.41617949
10Nucleotide excision repair_Homo sapiens_hsa034202.41183533
11Mismatch repair_Homo sapiens_hsa034302.37992699
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.21253641
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.18140362
14Vitamin digestion and absorption_Homo sapiens_hsa049772.12029338
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.11067932
16Caffeine metabolism_Homo sapiens_hsa002322.05602166
17Protein digestion and absorption_Homo sapiens_hsa049742.05234786
18Chemical carcinogenesis_Homo sapiens_hsa052041.96071341
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.95619273
20DNA replication_Homo sapiens_hsa030301.95036709
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.94966806
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.91763388
23Tryptophan metabolism_Homo sapiens_hsa003801.88154312
24Folate biosynthesis_Homo sapiens_hsa007901.85129596
25beta-Alanine metabolism_Homo sapiens_hsa004101.79171275
26Ovarian steroidogenesis_Homo sapiens_hsa049131.74631771
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.71345348
28Glutathione metabolism_Homo sapiens_hsa004801.68689923
29Peroxisome_Homo sapiens_hsa041461.64822580
30Fatty acid metabolism_Homo sapiens_hsa012121.64051612
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.62885491
32p53 signaling pathway_Homo sapiens_hsa041151.61778825
33Histidine metabolism_Homo sapiens_hsa003401.61528312
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.59967849
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58888928
36Thyroid cancer_Homo sapiens_hsa052161.58703654
37Vitamin B6 metabolism_Homo sapiens_hsa007501.58338978
38Oocyte meiosis_Homo sapiens_hsa041141.58180148
39RNA transport_Homo sapiens_hsa030131.55053044
40Base excision repair_Homo sapiens_hsa034101.53678918
41Renin-angiotensin system_Homo sapiens_hsa046141.51567653
42Selenocompound metabolism_Homo sapiens_hsa004501.44816663
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.44497754
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.43119474
45Homologous recombination_Homo sapiens_hsa034401.42124860
46Pyruvate metabolism_Homo sapiens_hsa006201.38503575
47PPAR signaling pathway_Homo sapiens_hsa033201.36561484
48Mineral absorption_Homo sapiens_hsa049781.34439124
49Pancreatic secretion_Homo sapiens_hsa049721.29836765
50Starch and sucrose metabolism_Homo sapiens_hsa005001.27913133
51TGF-beta signaling pathway_Homo sapiens_hsa043501.27879894
52Arginine biosynthesis_Homo sapiens_hsa002201.27801171
53RNA degradation_Homo sapiens_hsa030181.27629731
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25890362
55Hippo signaling pathway_Homo sapiens_hsa043901.24422194
56ECM-receptor interaction_Homo sapiens_hsa045121.23486083
57Retinol metabolism_Homo sapiens_hsa008301.23250850
58Focal adhesion_Homo sapiens_hsa045101.16562316
59Carbon metabolism_Homo sapiens_hsa012001.14179215
60Phenylalanine metabolism_Homo sapiens_hsa003601.12877006
61Proteasome_Homo sapiens_hsa030501.12797171
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.11816563
63Glycerolipid metabolism_Homo sapiens_hsa005611.08140984
64ABC transporters_Homo sapiens_hsa020101.07078265
65Complement and coagulation cascades_Homo sapiens_hsa046101.06082001
66Fanconi anemia pathway_Homo sapiens_hsa034601.04766788
67Proteoglycans in cancer_Homo sapiens_hsa052051.04677192
68Small cell lung cancer_Homo sapiens_hsa052221.04306775
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.02515240
70Sulfur relay system_Homo sapiens_hsa041221.02251965
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01775551
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99294307
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98879953
74Linoleic acid metabolism_Homo sapiens_hsa005910.98177192
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.97961841
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.97744299
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.96833862
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96473284
79Circadian rhythm_Homo sapiens_hsa047100.95228893
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.94661212
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93466063
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93059735
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92119162
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92073446
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.91068139
86Butanoate metabolism_Homo sapiens_hsa006500.90935090
87Arachidonic acid metabolism_Homo sapiens_hsa005900.88265638
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85031948
89Fatty acid elongation_Homo sapiens_hsa000620.84020063
90Bile secretion_Homo sapiens_hsa049760.83357500
91Arginine and proline metabolism_Homo sapiens_hsa003300.82098903
92Legionellosis_Homo sapiens_hsa051340.81914289
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81234894
94Fructose and mannose metabolism_Homo sapiens_hsa000510.81125852
95MicroRNAs in cancer_Homo sapiens_hsa052060.79061044
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78780583
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.77845672
98Vibrio cholerae infection_Homo sapiens_hsa051100.76446040
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75949529
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73214318
101RNA polymerase_Homo sapiens_hsa030200.72281473
102Pyrimidine metabolism_Homo sapiens_hsa002400.71310415
103Hedgehog signaling pathway_Homo sapiens_hsa043400.69418569
104Sphingolipid metabolism_Homo sapiens_hsa006000.64428273
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64132431
106Metabolic pathways_Homo sapiens_hsa011000.63326375
107Adherens junction_Homo sapiens_hsa045200.63326066
108Dorso-ventral axis formation_Homo sapiens_hsa043200.63259215
109Galactose metabolism_Homo sapiens_hsa000520.63053689
110Biosynthesis of amino acids_Homo sapiens_hsa012300.61696388
111Non-homologous end-joining_Homo sapiens_hsa034500.61334675
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60867556
113Gap junction_Homo sapiens_hsa045400.60791867
114Influenza A_Homo sapiens_hsa051640.56975949
115Bladder cancer_Homo sapiens_hsa052190.55668315
116Pentose phosphate pathway_Homo sapiens_hsa000300.55239965
117Purine metabolism_Homo sapiens_hsa002300.54580337
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52829927
119Lysine degradation_Homo sapiens_hsa003100.52500333
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52344859
121Tight junction_Homo sapiens_hsa045300.51966204
122Hepatitis C_Homo sapiens_hsa051600.51330206
123Wnt signaling pathway_Homo sapiens_hsa043100.50905499
124Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50746216
125Amoebiasis_Homo sapiens_hsa051460.49833091
126mRNA surveillance pathway_Homo sapiens_hsa030150.48623351
127Steroid biosynthesis_Homo sapiens_hsa001000.48245489
128One carbon pool by folate_Homo sapiens_hsa006700.47310047
129Toxoplasmosis_Homo sapiens_hsa051450.46396059
130Tyrosine metabolism_Homo sapiens_hsa003500.45544133
131Melanoma_Homo sapiens_hsa052180.42287333
132Oxidative phosphorylation_Homo sapiens_hsa001900.41982463
133Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41185814
134Staphylococcus aureus infection_Homo sapiens_hsa051500.41185258
135Pathways in cancer_Homo sapiens_hsa052000.40727427
136Fatty acid biosynthesis_Homo sapiens_hsa000610.37559487
137AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36782636
138Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33651537
139N-Glycan biosynthesis_Homo sapiens_hsa005100.32961998
140Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32714624
141Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32155687
142Leukocyte transendothelial migration_Homo sapiens_hsa046700.32019569
143TNF signaling pathway_Homo sapiens_hsa046680.30818286
144NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29163727
145RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28337712
146Pertussis_Homo sapiens_hsa051330.27904621

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