SH2D4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of fibroblast apoptotic process (GO:2000270)7.78183892
2biotin metabolic process (GO:0006768)7.73925907
3centriole replication (GO:0007099)7.56265639
4axoneme assembly (GO:0035082)7.19753013
5inflammatory response to antigenic stimulus (GO:0002437)6.87498256
6regulation of meiosis I (GO:0060631)6.81994271
7piRNA metabolic process (GO:0034587)6.65686621
8multicellular organism reproduction (GO:0032504)6.61960563
9regulation of protein glycosylation (GO:0060049)6.60121098
10negative regulation of glycoprotein biosynthetic process (GO:0010561)6.56978697
11sperm motility (GO:0030317)6.34119974
12protein polyglutamylation (GO:0018095)5.86640895
13fusion of sperm to egg plasma membrane (GO:0007342)5.83807200
14centriole assembly (GO:0098534)5.74568761
15epithelial cilium movement (GO:0003351)5.72689631
16protein targeting to Golgi (GO:0000042)5.72339585
17spindle assembly involved in mitosis (GO:0090307)5.71623144
18binding of sperm to zona pellucida (GO:0007339)5.64353371
19microtubule polymerization or depolymerization (GO:0031109)5.59913651
20chromosome condensation (GO:0030261)5.52873003
21sperm-egg recognition (GO:0035036)5.49605067
22establishment of protein localization to Golgi (GO:0072600)5.49452050
23acrosome reaction (GO:0007340)5.44864880
24regulation of histone H3-K9 methylation (GO:0051570)5.42357667
25DNA packaging (GO:0006323)5.42051141
26synapsis (GO:0007129)5.36466947
27vocalization behavior (GO:0071625)5.35949806
28retrograde transport, vesicle recycling within Golgi (GO:0000301)5.35037759
29spermatid nucleus differentiation (GO:0007289)5.25618170
30microtubule depolymerization (GO:0007019)5.22980291
31DNA methylation involved in gamete generation (GO:0043046)5.19878361
32negative regulation of T cell receptor signaling pathway (GO:0050860)5.17308894
33I-kappaB phosphorylation (GO:0007252)5.16546183
34regulation of centriole replication (GO:0046599)5.11187055
35regulation of fibroblast apoptotic process (GO:2000269)5.09726814
36regulation of DNA methylation (GO:0044030)4.99257798
37regulation of B cell receptor signaling pathway (GO:0050855)4.98373384
38nucleoside diphosphate phosphorylation (GO:0006165)4.96864356
39reproduction (GO:0000003)4.89937709
40male meiosis I (GO:0007141)4.89007013
41auditory behavior (GO:0031223)4.87556899
42negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.86344713
43negative regulation of glycoprotein metabolic process (GO:1903019)4.84039360
44postsynaptic membrane organization (GO:0001941)4.82755201
45meiotic cell cycle (GO:0051321)4.75738133
46negative regulation of viral genome replication (GO:0045071)4.69865362
47radial glial cell differentiation (GO:0060019)4.67459591
48spermatogenesis (GO:0007283)4.63007733
49male gamete generation (GO:0048232)4.61737170
50NIK/NF-kappaB signaling (GO:0038061)4.60242221
51seminiferous tubule development (GO:0072520)4.56329266
52microtubule cytoskeleton organization involved in mitosis (GO:1902850)4.56294048
53spermatid development (GO:0007286)4.54884197
54regulation of dendritic cell antigen processing and presentation (GO:0002604)4.54508815
55negative regulation of histone methylation (GO:0031061)4.54172549
56glycine transport (GO:0015816)4.53772164
57chromosome organization involved in meiosis (GO:0070192)4.46565641
58single fertilization (GO:0007338)4.43597039
59oocyte development (GO:0048599)4.42939130
60gamete generation (GO:0007276)4.41420095
61single strand break repair (GO:0000012)4.38713354
62male meiosis (GO:0007140)4.38403904
63bundle of His cell to Purkinje myocyte communication (GO:0086069)4.37188564
64fertilization (GO:0009566)4.36715643
65sperm capacitation (GO:0048240)4.34836242
66regulation of retinoic acid receptor signaling pathway (GO:0048385)4.32783644
67JAK-STAT cascade (GO:0007259)4.32048342
68cell-cell recognition (GO:0009988)4.31718560
69plasma membrane fusion (GO:0045026)4.30498965
70fibroblast migration (GO:0010761)4.29810667
71branching involved in labyrinthine layer morphogenesis (GO:0060670)4.28698799
72peptidyl-tyrosine autophosphorylation (GO:0038083)4.28631903
73ovulation cycle (GO:0042698)4.19401020
74microtubule severing (GO:0051013)4.14565595
75synaptonemal complex assembly (GO:0007130)4.12541801
76regulation of acrosome reaction (GO:0060046)4.12516472
77sphingosine metabolic process (GO:0006670)4.10786753
78positive regulation of heat generation (GO:0031652)4.05508173
79positive regulation of respiratory burst (GO:0060267)4.05084204
80protein localization to Golgi apparatus (GO:0034067)4.03999945
81meiotic cell cycle process (GO:1903046)4.02689978
82positive regulation of transcription from RNA polymerase III promoter (GO:0045945)4.01643216
83rRNA methylation (GO:0031167)4.00864227
84male sex determination (GO:0030238)4.00471322
85female gamete generation (GO:0007292)3.94492600
86tongue development (GO:0043586)3.93767920
87meiosis I (GO:0007127)3.89835054
88attachment of spindle microtubules to kinetochore (GO:0008608)3.81967738
89synaptonemal complex organization (GO:0070193)3.81800952
90microtubule bundle formation (GO:0001578)3.79927999
91regulation of cellular extravasation (GO:0002691)3.76183138
92regulation of MHC class I biosynthetic process (GO:0045343)3.75953498
93calcium ion-dependent exocytosis (GO:0017156)3.75727059
94negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.75677922
95cilium movement (GO:0003341)3.75509848
96diol metabolic process (GO:0034311)3.75032732
97sphingoid metabolic process (GO:0046519)3.71160835
98positive regulation of mitotic sister chromatid separation (GO:1901970)3.68287421
99positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.68287421
100positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.68287421
101microtubule nucleation (GO:0007020)3.67597543
102negative regulation of keratinocyte proliferation (GO:0010839)3.66830997
103somite rostral/caudal axis specification (GO:0032525)3.66109803
104nephron tubule formation (GO:0072079)3.64980091
105cilium or flagellum-dependent cell motility (GO:0001539)3.64455841
106resolution of meiotic recombination intermediates (GO:0000712)3.63453290
107meiotic nuclear division (GO:0007126)3.61938065
108germ cell development (GO:0007281)3.59809656
109nucleus organization (GO:0006997)3.59325386
110regulation of phospholipid biosynthetic process (GO:0071071)3.58680219
111rRNA modification (GO:0000154)3.57530375
112axonemal dynein complex assembly (GO:0070286)3.56777792
113positive regulation of growth hormone secretion (GO:0060124)3.54637362
114hemidesmosome assembly (GO:0031581)3.54336530
115regulation of glycoprotein biosynthetic process (GO:0010559)3.53119598
116histone H3-K9 demethylation (GO:0033169)3.52331697
117facial nerve structural organization (GO:0021612)3.49143143
118mechanosensory behavior (GO:0007638)3.46349810
119positive regulation of uterine smooth muscle contraction (GO:0070474)3.46183733
120histone exchange (GO:0043486)3.41252786
121virion attachment to host cell (GO:0019062)3.40055808
122adhesion of symbiont to host cell (GO:0044650)3.40055808
123regulation of T cell receptor signaling pathway (GO:0050856)3.39999798
124multicellular organismal reproductive process (GO:0048609)3.39324791
125positive regulation of gastrulation (GO:2000543)3.36948780
126tRNA methylation (GO:0030488)3.36714989
127exocrine pancreas development (GO:0031017)3.36467219
128cellular process involved in reproduction in multicellular organism (GO:0022412)3.35471630
129RNA destabilization (GO:0050779)3.35464500
130positive regulation of CREB transcription factor activity (GO:0032793)3.32864214
131epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.30920136
132ganglion development (GO:0061548)3.29501070
133nuclear pore organization (GO:0006999)3.28710209
134gland morphogenesis (GO:0022612)3.24615109
135mating behavior (GO:0007617)3.24133849
136gene silencing by RNA (GO:0031047)3.21625450
137RNA methylation (GO:0001510)3.19637483
138centrosome duplication (GO:0051298)3.19320210
139sister chromatid cohesion (GO:0007062)3.18897151
140positive regulation of granulocyte chemotaxis (GO:0071624)3.13500215
141regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.13070745
142positive regulation of antigen processing and presentation (GO:0002579)3.11916748
143positive regulation of chromosome segregation (GO:0051984)3.10097669
144regulation of natural killer cell activation (GO:0032814)3.08647323
145generation of neurons (GO:0048699)3.06943933
146regulation of centrosome cycle (GO:0046605)3.05035357
147pyrimidine dimer repair (GO:0006290)3.04958108
148positive regulation of histone H3-K4 methylation (GO:0051571)3.03283184
149gene silencing (GO:0016458)3.02917734
150response to auditory stimulus (GO:0010996)3.00731764
151nuclear pore complex assembly (GO:0051292)3.00722199
152neuron cell-cell adhesion (GO:0007158)2.99283942
153regulation of viral genome replication (GO:0045069)2.98064023
154regulation of cilium movement (GO:0003352)2.97141744
155regulation of heat generation (GO:0031650)2.94962001
156collecting duct development (GO:0072044)2.92174978
157keratinocyte development (GO:0003334)2.91701001
158DNA replication checkpoint (GO:0000076)2.91383316
159protein kinase C signaling (GO:0070528)2.90950223
160DNA topological change (GO:0006265)2.90128190
161antigen processing and presentation of endogenous antigen (GO:0019883)2.90104661
162regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.85500746
163positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.81827193
164regulation of glycoprotein metabolic process (GO:1903018)2.80434876
165apoptotic process involved in morphogenesis (GO:0060561)2.80138296
166phosphatidylethanolamine biosynthetic process (GO:0006646)2.79821433
167regulation of T-helper 1 cell differentiation (GO:0045625)2.73134406
168cranial nerve structural organization (GO:0021604)2.72965816
169proline transport (GO:0015824)2.72294569
170apoptotic process involved in development (GO:1902742)2.71123184
171positive regulation of glycoprotein biosynthetic process (GO:0010560)2.66803682
172musculoskeletal movement (GO:0050881)2.64900446
173multicellular organismal movement (GO:0050879)2.64900446
174positive regulation of neutrophil chemotaxis (GO:0090023)2.64098434
175positive regulation of neutrophil migration (GO:1902624)2.64098434
176regulation of growth hormone secretion (GO:0060123)2.62798074
177eye photoreceptor cell differentiation (GO:0001754)2.59419951
178photoreceptor cell differentiation (GO:0046530)2.59419951
179regulation of antigen processing and presentation (GO:0002577)2.56754235
180regulation of female gonad development (GO:2000194)2.55343434
181T cell lineage commitment (GO:0002360)2.54344547
182adhesion of symbiont to host (GO:0044406)2.53536555
183CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.52578765
184activation of Rac GTPase activity (GO:0032863)2.51965378
185regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.51856286
186regulation of transcription from RNA polymerase III promoter (GO:0006359)2.51497196
187dentate gyrus development (GO:0021542)2.49268572
188positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.48970984
189regulation of interleukin-13 production (GO:0032656)2.47498512
190phosphatidylethanolamine metabolic process (GO:0046337)2.47491068
191vesicle transport along microtubule (GO:0047496)2.46403808
192forebrain neuron differentiation (GO:0021879)2.46395404
193regulation of cellular respiration (GO:0043457)2.45633054
194glycoprotein catabolic process (GO:0006516)2.45327690
195dendritic cell differentiation (GO:0097028)2.44686037
196positive regulation of DNA-templated transcription, initiation (GO:2000144)2.43907048

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.71532902
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.04665250
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.68247088
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.49750045
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.30591283
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.28812258
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.23546373
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.98210401
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.94078067
10ZNF274_21170338_ChIP-Seq_K562_Hela2.72390368
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.68463926
12E2F7_22180533_ChIP-Seq_HELA_Human2.57061362
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.56879160
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.55146127
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.51322092
16CBP_20019798_ChIP-Seq_JUKART_Human2.29605841
17IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.29605841
18* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.28699752
19* POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.28699752
20SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.25104622
21FUS_26573619_Chip-Seq_HEK293_Human2.21750896
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.19156263
23* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human2.16677397
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11631017
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11325266
26TP63_19390658_ChIP-ChIP_HaCaT_Human2.10547450
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.08359051
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.02456628
29KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.00565180
30KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.00565180
31KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.00565180
32EZH2_18974828_ChIP-Seq_MESCs_Mouse2.00474651
33RNF2_18974828_ChIP-Seq_MESCs_Mouse2.00474651
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.93815994
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.88711316
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.87861865
37BP1_19119308_ChIP-ChIP_Hs578T_Human1.84715264
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.80516833
39* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.70845176
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.70035219
41* P300_19829295_ChIP-Seq_ESCs_Human1.69472439
42PRDM14_20953172_ChIP-Seq_ESCs_Human1.68778616
43JARID2_20064375_ChIP-Seq_MESCs_Mouse1.67953899
44NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.67950739
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.66075388
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.63074262
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.61183375
48SMAD4_21741376_ChIP-Seq_EPCs_Human1.61075845
49GBX2_23144817_ChIP-Seq_PC3_Human1.60499815
50TP53_20018659_ChIP-ChIP_R1E_Mouse1.59744908
51JARID2_20075857_ChIP-Seq_MESCs_Mouse1.58966327
52ER_23166858_ChIP-Seq_MCF-7_Human1.57912557
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.55742115
54SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54781389
55VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.52959607
56SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.51286596
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.50209127
58EWS_26573619_Chip-Seq_HEK293_Human1.43776838
59NANOG_20526341_ChIP-Seq_ESCs_Human1.42271431
60* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.41803566
61ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39894971
62SMRT_27268052_Chip-Seq_Bcells_Human1.39548189
63RNF2_27304074_Chip-Seq_ESCs_Mouse1.39183526
64TAF15_26573619_Chip-Seq_HEK293_Human1.38551066
65HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.38097879
66* AHR_22903824_ChIP-Seq_MCF-7_Human1.36612267
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34879384
68Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.33539783
69EZH2_27304074_Chip-Seq_ESCs_Mouse1.31385733
70RING1B_27294783_Chip-Seq_NPCs_Mouse1.31318078
71GATA3_21878914_ChIP-Seq_MCF-7_Human1.30944594
72SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30536081
73ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30431726
74ZFP281_27345836_Chip-Seq_ESCs_Mouse1.29962961
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.29631953
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.28906390
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.28843779
78POU5F1_16518401_ChIP-PET_MESCs_Mouse1.28029196
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25913504
80STAT3_23295773_ChIP-Seq_U87_Human1.25548303
81TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25238730
82WDR5_24793694_ChIP-Seq_LNCAP_Human1.25074609
83NCOR_22424771_ChIP-Seq_293T_Human1.25059021
84SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.22845375
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22816803
86E2F1_17053090_ChIP-ChIP_MCF-7_Human1.22792758
87FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22225492
88AUTS2_25519132_ChIP-Seq_293T-REX_Human1.20977409
89* RUNX2_22187159_ChIP-Seq_PCA_Human1.20540528
90TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.19553013
91SMAD3_21741376_ChIP-Seq_HESCs_Human1.19529986
92RNF2_27304074_Chip-Seq_NSC_Mouse1.19440053
93MTF2_20144788_ChIP-Seq_MESCs_Mouse1.18688224
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18263327
95KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.16307200
96NOTCH1_21737748_ChIP-Seq_TLL_Human1.15552198
97TCF4_23295773_ChIP-Seq_U87_Human1.13828532
98NANOG_19829295_ChIP-Seq_ESCs_Human1.12720242
99SOX2_19829295_ChIP-Seq_ESCs_Human1.12720242
100IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12273095
101* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11659379
102TCF4_22108803_ChIP-Seq_LS180_Human1.10101570
103SMAD4_21799915_ChIP-Seq_A2780_Human1.09551974
104TP53_22573176_ChIP-Seq_HFKS_Human1.08887294
105SALL4_22934838_ChIP-ChIP_CD34+_Human1.08635042
106RAC3_21632823_ChIP-Seq_H3396_Human1.08500147
107TAF2_19829295_ChIP-Seq_ESCs_Human1.07555816
108* ARNT_22903824_ChIP-Seq_MCF-7_Human1.07154278
109PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.06985786
110* MYC_19829295_ChIP-Seq_ESCs_Human1.06191294
111POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06055172
112NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.06034558
113SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05789559
114TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.05537983
115VDR_24787735_ChIP-Seq_THP-1_Human1.05331759
116FOXH1_21741376_ChIP-Seq_EPCs_Human1.04094293
117PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03842027
118EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03830890
119STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03513959
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03311110
121KDM2B_26808549_Chip-Seq_REH_Human1.03275577
122BCAT_22108803_ChIP-Seq_LS180_Human1.02816426
123ERA_21632823_ChIP-Seq_H3396_Human1.02785485
124FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02122356
125FOXA1_25329375_ChIP-Seq_VCAP_Human1.02122356
126SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01451133
127* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00532302
128KDM2B_26808549_Chip-Seq_K562_Human1.00436942
129RBPJ_21746931_ChIP-Seq_IB4_Human1.00231926
130* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99440271
131SMAD3_21741376_ChIP-Seq_ESCs_Human0.99305966
132GATA3_26560356_Chip-Seq_TH1_Human0.99233614
133IRF1_19129219_ChIP-ChIP_H3396_Human0.98752182
134* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98633362
135* TBL1_22424771_ChIP-Seq_293T_Human0.98012034
136NANOG_18692474_ChIP-Seq_MEFs_Mouse0.97562734
137ETV1_20927104_ChIP-Seq_GIST48_Human0.96771239
138TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95074373
139NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95026506
140* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94884787
141NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94018907
142PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93864226
143RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93829128
144CBX2_27304074_Chip-Seq_ESCs_Mouse0.92033808
145WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92007384
146SMAD_19615063_ChIP-ChIP_OVARY_Human0.91678229
147* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91213591
148MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91093714
149* NFYB_21822215_ChIP-Seq_K562_Human0.90902134
150TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89567233
151MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89274458
152* AR_25329375_ChIP-Seq_VCAP_Human0.88944610
153CBX2_22325352_ChIP-Seq_293T-Rex_Human0.88728182
154GF1_26923725_Chip-Seq_HPCs_Mouse0.88626292
155PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.88188530
156* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.88032195
157YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87846166
158SMAD4_21741376_ChIP-Seq_HESCs_Human0.87541504
159NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.87429192
160CEBPB_22108803_ChIP-Seq_LS180_Human0.87206880
161REST_21632747_ChIP-Seq_MESCs_Mouse0.86059524
162EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.85559764
163CTBP1_25329375_ChIP-Seq_LNCAP_Human0.84921291
164* TP63_23658742_ChIP-Seq_EP156T_Human0.84718555
165BMI1_23680149_ChIP-Seq_NPCS_Mouse0.84602245
166RING1B_27294783_Chip-Seq_ESCs_Mouse0.84507994
167EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84216022
168PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.84142452
169TCF4_18268006_ChIP-ChIP_LS174T_Human0.84045829
170NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83009523
171NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83009523
172FOXM1_26456572_ChIP-Seq_MCF-7_Human0.82854929
173TOP2B_26459242_ChIP-Seq_MCF-7_Human0.82430935
174* NANOG_16518401_ChIP-PET_MESCs_Mouse0.82355670
175EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.82009175
176* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.81667280
177RUNX1_26923725_Chip-Seq_HPCs_Mouse0.81102201
178CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.80183713
179ZFP281_18757296_ChIP-ChIP_E14_Mouse0.80094593
180KDM2B_26808549_Chip-Seq_SUP-B15_Human0.78652783
181WT1_25993318_ChIP-Seq_PODOCYTE_Human0.78609030
182GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.77924394
183* STAT1_17558387_ChIP-Seq_HELA_Human0.77770795
184PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.77186644
185SOX9_24532713_ChIP-Seq_HFSC_Mouse0.76022155
186SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75278604

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat9.01419500
2MP0005410_abnormal_fertilization6.16626709
3MP0008877_abnormal_DNA_methylation5.65858518
4MP0001346_abnormal_lacrimal_gland4.24355926
5MP0002876_abnormal_thyroid_physiology3.69946703
6MP0001929_abnormal_gametogenesis3.59396975
7MP0006292_abnormal_olfactory_placode3.45398579
8MP0001348_abnormal_lacrimal_gland3.44148548
9MP0003315_abnormal_perineum_morphology3.14638973
10MP0000685_abnormal_immune_system2.95654661
11MP0005075_abnormal_melanosome_morpholog2.91771338
12MP0003698_abnormal_male_reproductive2.89679190
13MP0005084_abnormal_gallbladder_morpholo2.77182404
14MP0001835_abnormal_antigen_presentation2.70344921
15MP0003890_abnormal_embryonic-extraembry2.67147160
16MP0002877_abnormal_melanocyte_morpholog2.52162218
17MP0000516_abnormal_urinary_system2.45354868
18MP0005367_renal/urinary_system_phenotyp2.45354868
19MP0005499_abnormal_olfactory_system2.44792616
20MP0005394_taste/olfaction_phenotype2.44792616
21MP0001986_abnormal_taste_sensitivity2.44444804
22MP0010094_abnormal_chromosome_stability2.43053241
23MP0002210_abnormal_sex_determination2.40242141
24MP0000569_abnormal_digit_pigmentation2.34883466
25MP0010368_abnormal_lymphatic_system2.31646047
26MP0005395_other_phenotype2.21847069
27MP0005670_abnormal_white_adipose2.18550375
28MP0004381_abnormal_hair_follicle2.11979145
29MP0005310_abnormal_salivary_gland2.09754883
30MP0004510_myositis2.05707990
31MP0002161_abnormal_fertility/fecundity2.04619485
32MP0002138_abnormal_hepatobiliary_system1.97864246
33MP0000653_abnormal_sex_gland1.97303167
34MP0003453_abnormal_keratinocyte_physiol1.86389037
35MP0005451_abnormal_body_composition1.83118275
36MP0003763_abnormal_thymus_physiology1.78337117
37MP0001145_abnormal_male_reproductive1.76553114
38MP0003878_abnormal_ear_physiology1.76203933
39MP0005377_hearing/vestibular/ear_phenot1.76203933
40MP0001879_abnormal_lymphatic_vessel1.75801165
41MP0008058_abnormal_DNA_repair1.75343457
42MP0001485_abnormal_pinna_reflex1.74522456
43MP0002653_abnormal_ependyma_morphology1.65217856
44MP0003077_abnormal_cell_cycle1.64488275
45MP0003699_abnormal_female_reproductive1.62449424
46MP0002098_abnormal_vibrissa_morphology1.56137119
47MP0004272_abnormal_basement_membrane1.55614112
48MP0003693_abnormal_embryo_hatching1.52855550
49MP0000613_abnormal_salivary_gland1.51684008
50MP0002234_abnormal_pharynx_morphology1.48549844
51MP0001119_abnormal_female_reproductive1.48016159
52MP0002405_respiratory_system_inflammati1.39096371
53MP0006072_abnormal_retinal_apoptosis1.37400771
54MP0002277_abnormal_respiratory_mucosa1.35294406
55MP0002127_abnormal_cardiovascular_syste1.34867840
56MP0010030_abnormal_orbit_morphology1.32133279
57MP0001849_ear_inflammation1.32000430
58MP0000733_abnormal_muscle_development1.25848652
59MP0002938_white_spotting1.25376443
60MP0000579_abnormal_nail_morphology1.24638250
61MP0000049_abnormal_middle_ear1.24199954
62MP0009250_abnormal_appendicular_skeleto1.23392733
63MP0003806_abnormal_nucleotide_metabolis1.22501592
64MP0003136_yellow_coat_color1.21215923
65MP0001873_stomach_inflammation1.21004574
66MP0003183_abnormal_peptide_metabolism1.20510763
67MP0005671_abnormal_response_to1.20193078
68MP0005365_abnormal_bile_salt1.19930079
69MP0008260_abnormal_autophagy1.19883188
70MP0003646_muscle_fatigue1.18926761
71MP0003718_maternal_effect1.18035563
72MP0005187_abnormal_penis_morphology1.16113194
73MP0003011_delayed_dark_adaptation1.13770807
74MP0009697_abnormal_copulation1.12909210
75MP0000858_altered_metastatic_potential1.12903188
76MP0005387_immune_system_phenotype1.12853901
77MP0001790_abnormal_immune_system1.12853901
78MP0004742_abnormal_vestibular_system1.11745015
79MP0008057_abnormal_DNA_replication1.11334933
80MP0009379_abnormal_foot_pigmentation1.11307259
81MP0003566_abnormal_cell_adhesion1.11083530
82MP0002735_abnormal_chemical_nociception1.10980988
83MP0006082_CNS_inflammation1.10896582
84MP0005551_abnormal_eye_electrophysiolog1.10141409
85MP0003119_abnormal_digestive_system1.10075638
86MP0002160_abnormal_reproductive_system1.09314367
87MP0003787_abnormal_imprinting1.08563444
88MP0005645_abnormal_hypothalamus_physiol1.07325316
89MP0001486_abnormal_startle_reflex1.07290811
90MP0000383_abnormal_hair_follicle1.06728982
91MP0003111_abnormal_nucleus_morphology1.03134932
92MP0005423_abnormal_somatic_nervous1.02141380
93MP0005647_abnormal_sex_gland1.01854898
94MP0001984_abnormal_olfaction1.01831642
95MP0004957_abnormal_blastocyst_morpholog1.00873408
96MP0003879_abnormal_hair_cell1.00218903
97MP0004782_abnormal_surfactant_physiolog0.99042220
98MP0003283_abnormal_digestive_organ0.98718148
99MP0004185_abnormal_adipocyte_glucose0.95539973
100MP0005000_abnormal_immune_tolerance0.94323641
101MP0005508_abnormal_skeleton_morphology0.93570770
102MP0001800_abnormal_humoral_immune0.93152707
103MP0001853_heart_inflammation0.92757396
104MP0003121_genomic_imprinting0.92635880
105MP0005389_reproductive_system_phenotype0.91684851
106MP0001963_abnormal_hearing_physiology0.91642715
107MP0010234_abnormal_vibrissa_follicle0.90361106
108MP0004858_abnormal_nervous_system0.89986456
109MP0003385_abnormal_body_wall0.88707221
110MP0003303_peritoneal_inflammation0.86160797
111MP0004947_skin_inflammation0.85964523
112MP0010678_abnormal_skin_adnexa0.85747776
113MP0002184_abnormal_innervation0.85590302
114MP0005380_embryogenesis_phenotype0.84925157
115MP0001672_abnormal_embryogenesis/_devel0.84925157
116MP0001730_embryonic_growth_arrest0.84530360
117MP0000681_abnormal_thyroid_gland0.84450051
118MP0005248_abnormal_Harderian_gland0.81683255
119MP0005623_abnormal_meninges_morphology0.80763013
120MP0008932_abnormal_embryonic_tissue0.80411500
121MP0000751_myopathy0.79537368
122MP0004043_abnormal_pH_regulation0.78222255
123MP0005379_endocrine/exocrine_gland_phen0.76810809
124MP0005666_abnormal_adipose_tissue0.76517443
125MP0000627_abnormal_mammary_gland0.76319629
126MP0001270_distended_abdomen0.75671114
127MP0005025_abnormal_response_to0.74532443
128MP0003091_abnormal_cell_migration0.74285495
129MP0002089_abnormal_postnatal_growth/wei0.72721280
130MP0005174_abnormal_tail_pigmentation0.72100219
131MP0002163_abnormal_gland_morphology0.72033783
132MP0000026_abnormal_inner_ear0.71923678
133MP0005023_abnormal_wound_healing0.71480199
134MP0000377_abnormal_hair_follicle0.71380983
135MP0002095_abnormal_skin_pigmentation0.69955430
136MP0002132_abnormal_respiratory_system0.69562304
137MP0003300_gastrointestinal_ulcer0.69154576
138MP0003941_abnormal_skin_development0.67180732
139MP0002111_abnormal_tail_morphology0.67102325
140MP0008789_abnormal_olfactory_epithelium0.66327471
141MP0000678_abnormal_parathyroid_gland0.65933576
142MP0004019_abnormal_vitamin_homeostasis0.65926324
143MP0010307_abnormal_tumor_latency0.64295171
144MP0000428_abnormal_craniofacial_morphol0.63691279
145MP0004885_abnormal_endolymph0.62673148
146MP0005360_urolithiasis0.62657578
147MP0000163_abnormal_cartilage_morphology0.62518211
148MP0002396_abnormal_hematopoietic_system0.61798363
149MP0004130_abnormal_muscle_cell0.61153475
150MP0005253_abnormal_eye_physiology0.59966503
151MP0000427_abnormal_hair_cycle0.59395763
152MP0009278_abnormal_bone_marrow0.59176407
153MP0001216_abnormal_epidermal_layer0.58613525
154MP0008995_early_reproductive_senescence0.58599880
155MP0005390_skeleton_phenotype0.58566187
156MP0002060_abnormal_skin_morphology0.58162414
157MP0002896_abnormal_bone_mineralization0.57927737
158MP0000537_abnormal_urethra_morphology0.57552979
159MP0001293_anophthalmia0.55531370
160MP0003935_abnormal_craniofacial_develop0.54871311
161MP0003638_abnormal_response/metabolism_0.54748301
162MP0004085_abnormal_heartbeat0.54630484
163MP0002249_abnormal_larynx_morphology0.54459934
164MP0002272_abnormal_nervous_system0.52911624
165MP0009115_abnormal_fat_cell0.52199789
166MP0003950_abnormal_plasma_membrane0.52042134
167MP0002229_neurodegeneration0.48639047
168MP0003984_embryonic_growth_retardation0.48184123
169MP0002006_tumorigenesis0.47098360
170MP0004215_abnormal_myocardial_fiber0.46923644
171MP0000631_abnormal_neuroendocrine_gland0.45795758
172MP0000015_abnormal_ear_pigmentation0.45357707
173MP0006054_spinal_hemorrhage0.44460372
174MP0002088_abnormal_embryonic_growth/wei0.43925567
175MP0000350_abnormal_cell_proliferation0.41096302
176MP0002166_altered_tumor_susceptibility0.40751692
177MP0003868_abnormal_feces_composition0.40282425
178MP0009785_altered_susceptibility_to0.39875439
179MP0009764_decreased_sensitivity_to0.37960398
180MP0000372_irregular_coat_pigmentation0.37220206
181MP0002233_abnormal_nose_morphology0.37064562
182MP0002572_abnormal_emotion/affect_behav0.36790194

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)8.36326358
2Action tremor (HP:0002345)7.72220888
3Myokymia (HP:0002411)7.51142141
4Gastrointestinal infarctions (HP:0005244)7.10858704
5Abnormality of binocular vision (HP:0011514)6.55730289
6Diplopia (HP:0000651)6.55730289
7Progressive cerebellar ataxia (HP:0002073)6.18320285
8Ureteral stenosis (HP:0000071)5.64069768
9Abnormality of the prostate (HP:0008775)5.57165887
10Ureteral obstruction (HP:0006000)5.09661997
11Sensorimotor neuropathy (HP:0007141)4.93052619
12Hypoglycemic seizures (HP:0002173)4.78624057
13Cheilitis (HP:0100825)4.77583658
14Pancreatic islet-cell hyperplasia (HP:0004510)4.67103015
15Enlarged penis (HP:0000040)4.64592780
16Long foot (HP:0001833)4.44258121
17Hypoplasia of the thymus (HP:0000778)4.28407623
18Hypoglycemic coma (HP:0001325)4.22700773
19Dynein arm defect of respiratory motile cilia (HP:0012255)4.22340409
20Absent/shortened dynein arms (HP:0200106)4.22340409
21Tubulointerstitial nephritis (HP:0001970)4.19118142
22B lymphocytopenia (HP:0010976)4.09780416
23Severe combined immunodeficiency (HP:0004430)4.06330296
24Osteomalacia (HP:0002749)3.98155551
25Insulin-resistant diabetes mellitus (HP:0000831)3.85847768
26Aortic dissection (HP:0002647)3.81678064
27Chronic hepatic failure (HP:0100626)3.74546631
28Abnormality of B cell number (HP:0010975)3.73165544
29Amaurosis fugax (HP:0100576)3.64382626
30Supernumerary spleens (HP:0009799)3.63970421
31Combined immunodeficiency (HP:0005387)3.61122429
32Delusions (HP:0000746)3.59771069
33Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.51984661
34Impulsivity (HP:0100710)3.51731206
35Arterial thrombosis (HP:0004420)3.49892044
36Dysdiadochokinesis (HP:0002075)3.46397127
37Papillary thyroid carcinoma (HP:0002895)3.42537860
38Abnormality of abdominal situs (HP:0011620)3.40517343
39Abdominal situs inversus (HP:0003363)3.40517343
40Severe visual impairment (HP:0001141)3.40278489
41Thyroiditis (HP:0100646)3.37407601
42Hyperinsulinemic hypoglycemia (HP:0000825)3.26100978
43Pulmonary fibrosis (HP:0002206)3.25535446
44Abnormality of male internal genitalia (HP:0000022)3.24222554
45Chronic obstructive pulmonary disease (HP:0006510)3.17796126
46Obstructive lung disease (HP:0006536)3.17796126
47Joint swelling (HP:0001386)3.14277980
48Mediastinal lymphadenopathy (HP:0100721)3.13140182
49Chromosomal breakage induced by crosslinking agents (HP:0003221)3.10484166
50Male infertility (HP:0003251)3.09731774
51Right ventricular cardiomyopathy (HP:0011663)3.09193873
52Abnormal ciliary motility (HP:0012262)3.08648863
53Infertility (HP:0000789)3.04468357
54Bony spicule pigmentary retinopathy (HP:0007737)3.03062633
55Hypophosphatemic rickets (HP:0004912)3.00979726
56Chronic mucocutaneous candidiasis (HP:0002728)2.94150565
57Recurrent cutaneous fungal infections (HP:0011370)2.94150565
58Spinal cord compression (HP:0002176)2.92307235
59Symptomatic seizures (HP:0011145)2.91583859
60Congenital, generalized hypertrichosis (HP:0004540)2.88326389
61Chromsome breakage (HP:0040012)2.88017729
62Reduced subcutaneous adipose tissue (HP:0003758)2.83002424
63Abnormal respiratory motile cilium physiology (HP:0012261)2.80778700
64Abnormality of calcium-phosphate metabolism (HP:0100530)2.76855436
65Abnormality of endocrine pancreas physiology (HP:0012093)2.73446282
66Abnormality of the pancreatic islet cells (HP:0006476)2.73446282
67Azoospermia (HP:0000027)2.73023260
68Aplasia/Hypoplasia of the earlobes (HP:0009906)2.69690936
69Chronic sinusitis (HP:0011109)2.66256404
70Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.65728361
71Abnormal respiratory epithelium morphology (HP:0012253)2.63750586
72Abnormal respiratory motile cilium morphology (HP:0005938)2.63750586
73Thickened helices (HP:0000391)2.63711523
74Chest pain (HP:0100749)2.62787573
75Gangrene (HP:0100758)2.61922771
76Gonadotropin excess (HP:0000837)2.60482523
77Panhypogammaglobulinemia (HP:0003139)2.57065691
78Nephronophthisis (HP:0000090)2.52676211
79Attenuation of retinal blood vessels (HP:0007843)2.51423409
80Tongue fasciculations (HP:0001308)2.51325328
81Elfin facies (HP:0004428)2.49745112
82Acrocyanosis (HP:0001063)2.49205828
83Aplasia/Hypoplasia of the uvula (HP:0010293)2.47620592
84Aplasia/Hypoplasia of the fovea (HP:0008060)2.45196415
85Hypoplasia of the fovea (HP:0007750)2.45196415
86Pulmonary infiltrates (HP:0002113)2.44705151
87Abnormality of macular pigmentation (HP:0008002)2.43272184
88Absent frontal sinuses (HP:0002688)2.42378568
89Abnormal spermatogenesis (HP:0008669)2.41635487
90Milia (HP:0001056)2.39924931
91Clubbing of toes (HP:0100760)2.37453080
92Truncal obesity (HP:0001956)2.37309558
93Thick nail (HP:0001805)2.35835444
94Hypoproteinemia (HP:0003075)2.34635188
95Muscle fibrillation (HP:0010546)2.33426398
96Asymmetry of the thorax (HP:0001555)2.30554983
97Premature graying of hair (HP:0002216)2.29499723
98Onycholysis (HP:0001806)2.26573053
99Clitoromegaly (HP:0000057)2.26264812
100Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.25462254
101Cone-rod dystrophy (HP:0000548)2.22051542
102Abnormality of the renal medulla (HP:0100957)2.20493647
103Hemoptysis (HP:0002105)2.18162829
104Abnormality of the fovea (HP:0000493)2.13856006
105Prostate neoplasm (HP:0100787)2.13347269
106Meckel diverticulum (HP:0002245)2.13269327
107Thyroid carcinoma (HP:0002890)2.12770086
108Fragile skin (HP:0001030)2.12270765
109Pendular nystagmus (HP:0012043)2.09747012
110Duodenal stenosis (HP:0100867)2.09641756
111Small intestinal stenosis (HP:0012848)2.09641756
112Tubulointerstitial abnormality (HP:0001969)2.08615829
113Pulmonary embolism (HP:0002204)2.08130601
114Abnormality of the ileum (HP:0001549)2.07811868
115Premature ovarian failure (HP:0008209)2.07613454
116Spinal cord lesions (HP:0100561)2.06039050
117Syringomyelia (HP:0003396)2.06039050
118Generalized aminoaciduria (HP:0002909)2.05820553
119Increased IgM level (HP:0003496)2.04634822
120Lip pit (HP:0100267)2.03773871
121Recurrent pneumonia (HP:0006532)2.01890426
122Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.00701207
123Dilatation of the ascending aorta (HP:0005111)1.98641238
124Anorexia (HP:0002039)1.98382001
125Abnormality of cochlea (HP:0000375)1.97463432
126Hypoalphalipoproteinemia (HP:0003233)1.96311309
127Meningitis (HP:0001287)1.95716879
128Abnormality of the pericardium (HP:0001697)1.95267299
129Tachypnea (HP:0002789)1.93343150
130Unilateral renal agenesis (HP:0000122)1.92508702
131Craniofacial hyperostosis (HP:0004493)1.90615418
132Median cleft lip (HP:0000161)1.90086459
133Abnormality of the renal collecting system (HP:0004742)1.90068537
134Short tibia (HP:0005736)1.88838614
135Oligodactyly (hands) (HP:0001180)1.88690572
136Aplasia/Hypoplasia of the macula (HP:0008059)1.88571923
137Tibial bowing (HP:0002982)1.88417724
138Joint hemorrhage (HP:0005261)1.88319908
139Abnormal delayed hypersensitivity skin test (HP:0002963)1.87683474
140Plantar hyperkeratosis (HP:0007556)1.85590116
141Aplasia/Hypoplasia of the tibia (HP:0005772)1.85558801
142Menstrual irregularities (HP:0000858)1.83361895
143Dysautonomia (HP:0002459)1.83087411
144Portal hypertension (HP:0001409)1.82526794
145Duplicated collecting system (HP:0000081)1.81889777
146Preauricular pit (HP:0004467)1.81849904
147Periauricular skin pits (HP:0100277)1.81849904
148Hyperglycemia (HP:0003074)1.81471756
149Submucous cleft hard palate (HP:0000176)1.81088795
150Abnormality of the preputium (HP:0100587)1.81023562
151Abnormality of chromosome stability (HP:0003220)1.79379334
152Aplasia/Hypoplasia of the thymus (HP:0010515)1.78892610
153Pancreatic cysts (HP:0001737)1.78677187
154Natal tooth (HP:0000695)1.78222218
155Abnormality of the parathyroid morphology (HP:0011766)1.78188133
156Abnormality of proline metabolism (HP:0010907)1.77994534
157Hydroxyprolinuria (HP:0003080)1.77994534
158Sandal gap (HP:0001852)1.77470104
159Abnormality of the gastric mucosa (HP:0004295)1.77344229
160Abnormality of midbrain morphology (HP:0002418)1.76958152
161Molar tooth sign on MRI (HP:0002419)1.76958152
162Carpal bone hypoplasia (HP:0001498)1.76170897
163Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.75227066
164Hyperpituitarism (HP:0010514)1.74380195
165Abnormality of glutamine family amino acid metabolism (HP:0010902)1.72974944
166Septo-optic dysplasia (HP:0100842)1.71612468
167Type I transferrin isoform profile (HP:0003642)1.71321339
168Cleft eyelid (HP:0000625)1.70841775
169Thrombophlebitis (HP:0004418)1.70458082
170Skin rash (HP:0000988)1.70197065
171Abnormal rod and cone electroretinograms (HP:0008323)1.70153484
172Hyperammonemia (HP:0001987)1.69903449
173Periorbital edema (HP:0100539)1.68845322
174Restrictive lung disease (HP:0002091)1.68311944
175Facial edema (HP:0000282)1.67384359
176Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.67153766
177Mixed hearing impairment (HP:0000410)1.65729950
178Agammaglobulinemia (HP:0004432)1.62107678
179Alacrima (HP:0000522)1.61779937
180Atrophic scars (HP:0001075)1.61312934
181Abnormality of the phalanges of the 2nd finger (HP:0009541)1.59469047
182Gingival bleeding (HP:0000225)1.59226714
183Hypercortisolism (HP:0001578)1.58015915
184Abnormality of the nasal septum (HP:0000419)1.56400043
185Vasculitis (HP:0002633)1.56348075
186Short 5th finger (HP:0009237)1.52229254
187Eczematoid dermatitis (HP:0000976)1.51961684
188Genetic anticipation (HP:0003743)1.50767635
189Keratoconjunctivitis (HP:0001096)1.50573351
190Pustule (HP:0200039)1.47604426
191Epistaxis (HP:0000421)1.47317350
192Short middle phalanx of the 5th finger (HP:0004220)1.45604586
193Depression (HP:0000716)1.45200004
194Fragile nails (HP:0001808)1.44233846

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK16.70371202
2TAOK26.36213823
3PLK46.09685962
4MAP3K35.74040513
5MAP2K34.83931049
6MAP3K114.81796599
7NLK3.47194393
8BRD42.60917060
9STK162.34716626
10MAP3K142.30072699
11MAP3K92.24500871
12MAP4K22.05997106
13TRIB32.00144125
14INSRR11.6550370
15NUAK11.91426480
16PLK21.77973003
17CDC42BPA1.63427281
18ACVR1B1.63377023
19MAPK151.54053770
20CDK91.51379960
21MAP3K11.48384604
22ERBB41.38669347
23GRK51.36225918
24UHMK11.26929822
25DDR21.25651928
26NEK61.25574819
27RIPK41.23709079
28ARAF1.22575550
29PIK3CG1.20888130
30MAP3K131.20864979
31MST41.20583510
32TESK21.20442497
33MAP3K51.13532233
34BMPR1B1.12683523
35TRIM281.12639385
36ITK1.10090083
37BRAF1.10087867
38MAPK131.08048661
39PNCK1.05735560
40CDK71.04101753
41TESK11.02315631
42NEK91.02304912
43MATK1.02093411
44CDK61.00665465
45BCR0.98203366
46ZAK0.95422181
47TIE10.94317327
48FGFR40.93062678
49NTRK30.92750155
50DYRK1B0.92137547
51AURKA0.89055876
52MET0.88673190
53ERBB30.88508459
54TEC0.86424759
55CDC70.86422982
56CDK190.84544314
57TGFBR20.84246761
58BTK0.84064220
59LATS20.83874647
60EPHA30.83112753
61KSR20.82727834
62SRPK10.80002160
63MAP2K70.78835948
64PTK20.77785422
65YES10.75270333
66STK240.75068528
67TAF10.74399381
68FES0.73679715
69FER0.73063793
70KDR0.72682045
71MAP3K40.72384633
72MAP3K80.72095885
73JAK20.68888366
74TTN0.68216487
75CDK30.67441310
76EIF2AK30.66510769
77ERBB20.64820145
78CHEK20.64692430
79IKBKB0.64454337
80KIT0.63962455
81DYRK30.62831697
82PLK10.61564702
83NEK20.60265373
84MAP3K70.59618799
85EPHB10.59594960
86CAMK1G0.59157693
87ATR0.58125023
88CHUK0.58121412
89STK100.58026823
90IRAK10.57455329
91STK30.55830038
92TYRO30.54101380
93BRSK10.52482935
94IRAK20.52473379
95CHEK10.52191635
96HIPK20.51352663
97CAMKK10.51147251
98CSK0.50712431
99CDK120.50485392
100EPHA20.50164250
101GRK10.46510794
102ADRBK20.45265261
103PAK20.45027516
104STK390.44854792
105CDK20.44791314
106TBK10.44336991
107VRK10.44235964
108TSSK60.44149787
109ALK0.43524555
110RPS6KB20.43144197
111TNIK0.42920858
112PRKCD0.42608568
113RAF10.42305776
114OXSR10.41138075
115SIK30.40448701
116BMPR20.40052115
117PRKD30.39243743
118PRKG10.39030792
119EPHB20.38301077
120GSK3A0.37990010
121MST1R0.37562317
122MOS0.36973276
123TYK20.36863913
124JAK10.36822741
125AKT30.35778161
126CDK140.35101376
127CDK11A0.34976691
128CASK0.34810306
129STK380.34802842
130EIF2AK20.34315192
131JAK30.34104179
132ILK0.32797952
133IGF1R0.32573812
134PDK10.32098086
135MARK10.31918566
136FGR0.31203834
137MAPK120.31021048
138CLK10.30484807
139CDK10.30378038
140PTK60.29833917
141WNK30.29221993
142MAPK110.29187384
143LATS10.28518712
144PTK2B0.28382454
145MARK30.28365570
146VRK20.27872067
147CDK150.27312813
148PLK30.27300226
149CDK180.26586357
150CSNK1G10.26225537
151CSNK1D0.26009340
152SYK0.25686648
153FRK0.23977329
154CSNK1G30.23843085
155KSR10.23808889
156PDGFRB0.23215613
157LYN0.22237806
158PIM10.22045850
159BUB10.20750255
160GRK60.20301887
161PDGFRA0.20076279
162PRKD20.19691772
163TGFBR10.19670644
164MAPK10.19423702
165NME20.19412561
166PAK40.19386909
167FGFR30.19318319
168TRPM70.19292491
169DAPK20.19191810
170ERN10.19053694
171GSK3B0.18687441
172CSF1R0.18217948
173BRSK20.17139978
174TAOK30.16547638
175RIPK10.16487608
176CDK40.15367160
177TTK0.15149271
178HCK0.14823112
179WNK10.14087078
180MAP3K100.13844632

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030223.87050780
2Base excision repair_Homo sapiens_hsa034103.42475530
3Fatty acid biosynthesis_Homo sapiens_hsa000613.14179026
4Cell cycle_Homo sapiens_hsa041103.03089514
5DNA replication_Homo sapiens_hsa030302.95658487
6Non-homologous end-joining_Homo sapiens_hsa034502.75025779
7RNA transport_Homo sapiens_hsa030132.70680661
8Olfactory transduction_Homo sapiens_hsa047402.65106820
9Mismatch repair_Homo sapiens_hsa034302.50250665
10Fanconi anemia pathway_Homo sapiens_hsa034602.40093332
11Ovarian steroidogenesis_Homo sapiens_hsa049132.30150541
12Cyanoamino acid metabolism_Homo sapiens_hsa004602.28572226
13Jak-STAT signaling pathway_Homo sapiens_hsa046302.22260523
14NF-kappa B signaling pathway_Homo sapiens_hsa040642.20033654
15Hippo signaling pathway_Homo sapiens_hsa043902.12325459
16Oocyte meiosis_Homo sapiens_hsa041142.10201671
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.07900746
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.95563357
19Antigen processing and presentation_Homo sapiens_hsa046121.88059688
20Tight junction_Homo sapiens_hsa045301.84454230
21Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.83118446
22RNA degradation_Homo sapiens_hsa030181.82692080
23Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.79743373
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.77677028
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.76773899
26Thyroid cancer_Homo sapiens_hsa052161.73390567
27Caffeine metabolism_Homo sapiens_hsa002321.70134835
28Sphingolipid signaling pathway_Homo sapiens_hsa040711.70055252
29mRNA surveillance pathway_Homo sapiens_hsa030151.64029212
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.60939073
31Primary immunodeficiency_Homo sapiens_hsa053401.60596008
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.57844668
33Toxoplasmosis_Homo sapiens_hsa051451.57801778
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57063058
35Nucleotide excision repair_Homo sapiens_hsa034201.56586821
36RNA polymerase_Homo sapiens_hsa030201.56366993
37Type II diabetes mellitus_Homo sapiens_hsa049301.56188752
38Basal cell carcinoma_Homo sapiens_hsa052171.56165555
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.55933353
40Sphingolipid metabolism_Homo sapiens_hsa006001.54223988
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.49901830
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.47704124
43Endometrial cancer_Homo sapiens_hsa052131.44527507
44TNF signaling pathway_Homo sapiens_hsa046681.43914508
45Adherens junction_Homo sapiens_hsa045201.39403679
46Small cell lung cancer_Homo sapiens_hsa052221.39383976
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.38145345
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.34826749
49Sulfur metabolism_Homo sapiens_hsa009201.29325502
50Dorso-ventral axis formation_Homo sapiens_hsa043201.27274853
51Axon guidance_Homo sapiens_hsa043601.26263813
52Nicotine addiction_Homo sapiens_hsa050331.19443455
53Osteoclast differentiation_Homo sapiens_hsa043801.15452380
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15390850
55Phototransduction_Homo sapiens_hsa047441.13531017
56Hepatitis C_Homo sapiens_hsa051601.11509713
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09480133
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08145033
59Insulin resistance_Homo sapiens_hsa049311.07601769
60Colorectal cancer_Homo sapiens_hsa052101.07467979
61ECM-receptor interaction_Homo sapiens_hsa045121.05729043
62Taste transduction_Homo sapiens_hsa047421.05251163
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04673447
64Toll-like receptor signaling pathway_Homo sapiens_hsa046201.03240866
65Type I diabetes mellitus_Homo sapiens_hsa049401.02455249
66Influenza A_Homo sapiens_hsa051641.02367187
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00523571
68Complement and coagulation cascades_Homo sapiens_hsa046100.99652869
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.98023201
70Linoleic acid metabolism_Homo sapiens_hsa005910.98022585
71T cell receptor signaling pathway_Homo sapiens_hsa046600.96414558
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94853784
73GnRH signaling pathway_Homo sapiens_hsa049120.94723747
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93561361
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93249432
76Measles_Homo sapiens_hsa051620.92559825
77Wnt signaling pathway_Homo sapiens_hsa043100.92530427
78Pancreatic cancer_Homo sapiens_hsa052120.91414688
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90770044
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.89476089
81Acute myeloid leukemia_Homo sapiens_hsa052210.89311076
82Purine metabolism_Homo sapiens_hsa002300.88717309
83Pyrimidine metabolism_Homo sapiens_hsa002400.88534705
84Prolactin signaling pathway_Homo sapiens_hsa049170.88196821
85Arginine biosynthesis_Homo sapiens_hsa002200.88160866
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87178047
87Leishmaniasis_Homo sapiens_hsa051400.86966871
88Spliceosome_Homo sapiens_hsa030400.86167915
89Morphine addiction_Homo sapiens_hsa050320.84967279
90Amoebiasis_Homo sapiens_hsa051460.83619733
91Proteoglycans in cancer_Homo sapiens_hsa052050.83530424
92ABC transporters_Homo sapiens_hsa020100.82822388
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82125789
94Rap1 signaling pathway_Homo sapiens_hsa040150.82109215
95Focal adhesion_Homo sapiens_hsa045100.81492660
96Histidine metabolism_Homo sapiens_hsa003400.80936515
97Chemokine signaling pathway_Homo sapiens_hsa040620.80936018
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80075705
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79896035
100MicroRNAs in cancer_Homo sapiens_hsa052060.78383001
101Fatty acid metabolism_Homo sapiens_hsa012120.78182344
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.77820828
103Serotonergic synapse_Homo sapiens_hsa047260.77766594
104Hedgehog signaling pathway_Homo sapiens_hsa043400.77226348
105Inositol phosphate metabolism_Homo sapiens_hsa005620.76712725
106Fatty acid elongation_Homo sapiens_hsa000620.76622181
107Pathways in cancer_Homo sapiens_hsa052000.75413283
108Propanoate metabolism_Homo sapiens_hsa006400.74845971
109Herpes simplex infection_Homo sapiens_hsa051680.74329682
110AMPK signaling pathway_Homo sapiens_hsa041520.73361682
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73091626
112ErbB signaling pathway_Homo sapiens_hsa040120.72187192
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.70637134
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70454398
115African trypanosomiasis_Homo sapiens_hsa051430.69398613
116Chronic myeloid leukemia_Homo sapiens_hsa052200.69212835
117Prostate cancer_Homo sapiens_hsa052150.68999925
118Folate biosynthesis_Homo sapiens_hsa007900.68491159
119Bladder cancer_Homo sapiens_hsa052190.68487393
120Apoptosis_Homo sapiens_hsa042100.68025070
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67957734
122Allograft rejection_Homo sapiens_hsa053300.67749144
123Melanoma_Homo sapiens_hsa052180.67628532
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66944142
125Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65859430
126FoxO signaling pathway_Homo sapiens_hsa040680.65074339
127Viral carcinogenesis_Homo sapiens_hsa052030.64559947
128p53 signaling pathway_Homo sapiens_hsa041150.61235684
129Hepatitis B_Homo sapiens_hsa051610.61022253
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60829522
131Estrogen signaling pathway_Homo sapiens_hsa049150.60560093
132Epstein-Barr virus infection_Homo sapiens_hsa051690.60063887
133Huntingtons disease_Homo sapiens_hsa050160.59886588
134Melanogenesis_Homo sapiens_hsa049160.59305647
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58892332
136Dopaminergic synapse_Homo sapiens_hsa047280.58226337
137Homologous recombination_Homo sapiens_hsa034400.56054603
138Non-small cell lung cancer_Homo sapiens_hsa052230.55978636
139Glutamatergic synapse_Homo sapiens_hsa047240.55966757
140cAMP signaling pathway_Homo sapiens_hsa040240.55511913
141HTLV-I infection_Homo sapiens_hsa051660.55356601
142Phenylalanine metabolism_Homo sapiens_hsa003600.54868945
143B cell receptor signaling pathway_Homo sapiens_hsa046620.53664963
144Cysteine and methionine metabolism_Homo sapiens_hsa002700.52636779
145Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52541082
146Autoimmune thyroid disease_Homo sapiens_hsa053200.52270848
147Graft-versus-host disease_Homo sapiens_hsa053320.52215249
148Phospholipase D signaling pathway_Homo sapiens_hsa040720.52116383
149Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51648425
150GABAergic synapse_Homo sapiens_hsa047270.51024496
151Vitamin B6 metabolism_Homo sapiens_hsa007500.50232939
152Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48131423
153Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48127901
154Oxytocin signaling pathway_Homo sapiens_hsa049210.45980498
155PPAR signaling pathway_Homo sapiens_hsa033200.45623385
156TGF-beta signaling pathway_Homo sapiens_hsa043500.45326887
157Choline metabolism in cancer_Homo sapiens_hsa052310.45254655
158Ether lipid metabolism_Homo sapiens_hsa005650.44339820
159Circadian entrainment_Homo sapiens_hsa047130.39353465
160Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37957287
161Calcium signaling pathway_Homo sapiens_hsa040200.36862104
162Butanoate metabolism_Homo sapiens_hsa006500.35702433
163Cholinergic synapse_Homo sapiens_hsa047250.29809913
164MAPK signaling pathway_Homo sapiens_hsa040100.27458437
165Circadian rhythm_Homo sapiens_hsa047100.27035701
166SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26545698
167Vascular smooth muscle contraction_Homo sapiens_hsa042700.26448934
168Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24478437
169Ras signaling pathway_Homo sapiens_hsa040140.24149446
170Hematopoietic cell lineage_Homo sapiens_hsa046400.22772123
171Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20776313
172Long-term depression_Homo sapiens_hsa047300.18502694
173Cardiac muscle contraction_Homo sapiens_hsa042600.18205776

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