

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | hemidesmosome assembly (GO:0031581) | 8.95411808 |
| 2 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 6.34339590 |
| 3 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 6.16510264 |
| 4 | synaptic vesicle maturation (GO:0016188) | 6.14979954 |
| 5 | locomotory exploration behavior (GO:0035641) | 5.79807880 |
| 6 | regulation of synapse structural plasticity (GO:0051823) | 5.53293518 |
| 7 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.49956903 |
| 8 | synaptic vesicle exocytosis (GO:0016079) | 5.49750504 |
| 9 | vocalization behavior (GO:0071625) | 5.46678010 |
| 10 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.37074622 |
| 11 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 5.27201471 |
| 12 | regulation of glutamate receptor signaling pathway (GO:1900449) | 5.24317675 |
| 13 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 5.10576975 |
| 14 | sodium ion export (GO:0071436) | 4.96751734 |
| 15 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.95756114 |
| 16 | prepulse inhibition (GO:0060134) | 4.91821382 |
| 17 | regulation of neuronal synaptic plasticity (GO:0048168) | 4.85634275 |
| 18 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.84790330 |
| 19 | synaptic transmission, dopaminergic (GO:0001963) | 4.83899666 |
| 20 | cell-substrate junction assembly (GO:0007044) | 4.80035188 |
| 21 | protein localization to synapse (GO:0035418) | 4.69895603 |
| 22 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.68266604 |
| 23 | neuronal action potential propagation (GO:0019227) | 4.65638597 |
| 24 | glutamate secretion (GO:0014047) | 4.62373706 |
| 25 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 4.59906769 |
| 26 | neurotransmitter secretion (GO:0007269) | 4.55783208 |
| 27 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 4.53542169 |
| 28 | positive regulation of neurotransmitter transport (GO:0051590) | 4.49624487 |
| 29 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 4.49567469 |
| 30 | regulation of synaptic vesicle transport (GO:1902803) | 4.48473708 |
| 31 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 4.45147356 |
| 32 | neuron-neuron synaptic transmission (GO:0007270) | 4.44550844 |
| 33 | positive regulation of membrane potential (GO:0045838) | 4.42860392 |
| 34 | synaptic transmission, glutamatergic (GO:0035249) | 4.39994088 |
| 35 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 4.29784682 |
| 36 | exploration behavior (GO:0035640) | 4.27587135 |
| 37 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 4.25851426 |
| 38 | long-term memory (GO:0007616) | 4.25267893 |
| 39 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 4.24528691 |
| 40 | striatum development (GO:0021756) | 4.23277175 |
| 41 | positive regulation of neurotransmitter secretion (GO:0001956) | 4.19552415 |
| 42 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 4.18175384 |
| 43 | auditory behavior (GO:0031223) | 4.17449499 |
| 44 | glutamate receptor signaling pathway (GO:0007215) | 4.16119227 |
| 45 | regulation of dendritic spine morphogenesis (GO:0061001) | 4.11189822 |
| 46 | desmosome organization (GO:0002934) | 4.06457836 |
| 47 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 4.04702462 |
| 48 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 4.00853285 |
| 49 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.99556494 |
| 50 | regulation of postsynaptic membrane potential (GO:0060078) | 3.97235812 |
| 51 | response to amphetamine (GO:0001975) | 3.97119165 |
| 52 | neuron cell-cell adhesion (GO:0007158) | 3.91871200 |
| 53 | dendritic spine morphogenesis (GO:0060997) | 3.90991592 |
| 54 | dopamine receptor signaling pathway (GO:0007212) | 3.88453885 |
| 55 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.88402744 |
| 56 | amino acid import (GO:0043090) | 3.87588962 |
| 57 | regulation of synaptic plasticity (GO:0048167) | 3.87411281 |
| 58 | adenosine receptor signaling pathway (GO:0001973) | 3.83878753 |
| 59 | transmission of nerve impulse (GO:0019226) | 3.75524808 |
| 60 | behavioral response to cocaine (GO:0048148) | 3.75298576 |
| 61 | regulation of dopamine uptake involved in synaptic transmission (GO:0051584) | 3.74986695 |
| 62 | regulation of catecholamine uptake involved in synaptic transmission (GO:0051940) | 3.74986695 |
| 63 | response to histamine (GO:0034776) | 3.71900113 |
| 64 | response to auditory stimulus (GO:0010996) | 3.71278434 |
| 65 | long-term synaptic potentiation (GO:0060291) | 3.70911786 |
| 66 | neuromuscular process controlling balance (GO:0050885) | 3.70653429 |
| 67 | regulation of glutamate secretion (GO:0014048) | 3.68289240 |
| 68 | regulation of female receptivity (GO:0045924) | 3.68084466 |
| 69 | mechanosensory behavior (GO:0007638) | 3.65815714 |
| 70 | layer formation in cerebral cortex (GO:0021819) | 3.65775640 |
| 71 | behavioral fear response (GO:0001662) | 3.63440351 |
| 72 | behavioral defense response (GO:0002209) | 3.63440351 |
| 73 | positive regulation of synapse maturation (GO:0090129) | 3.60185565 |
| 74 | membrane hyperpolarization (GO:0060081) | 3.56436741 |
| 75 | activation of protein kinase A activity (GO:0034199) | 3.56054931 |
| 76 | neurotransmitter transport (GO:0006836) | 3.55642790 |
| 77 | gamma-aminobutyric acid transport (GO:0015812) | 3.54666177 |
| 78 | cellular potassium ion homeostasis (GO:0030007) | 3.52585016 |
| 79 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 3.51732910 |
| 80 | neuronal ion channel clustering (GO:0045161) | 3.49533295 |
| 81 | regulation of neurotransmitter levels (GO:0001505) | 3.47611417 |
| 82 | protein localization to endosome (GO:0036010) | 3.46937462 |
| 83 | regulation of neurotransmitter uptake (GO:0051580) | 3.46304724 |
| 84 | visual learning (GO:0008542) | 3.42554605 |
| 85 | regulation of neurotransmitter transport (GO:0051588) | 3.41756862 |
| 86 | regulation of neurotransmitter secretion (GO:0046928) | 3.41343341 |
| 87 | cAMP catabolic process (GO:0006198) | 3.41210960 |
| 88 | positive regulation of synaptic transmission (GO:0050806) | 3.39691000 |
| 89 | learning (GO:0007612) | 3.36729243 |
| 90 | membrane depolarization (GO:0051899) | 3.36546046 |
| 91 | regulation of protein kinase A signaling (GO:0010738) | 3.36135911 |
| 92 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.34572457 |
| 93 | regulation of dendritic spine development (GO:0060998) | 3.32825629 |
| 94 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.31618874 |
| 95 | keratinocyte proliferation (GO:0043616) | 3.30262817 |
| 96 | cell-substrate adherens junction assembly (GO:0007045) | 3.27728626 |
| 97 | focal adhesion assembly (GO:0048041) | 3.27728626 |
| 98 | fear response (GO:0042596) | 3.26969099 |
| 99 | regulation of synaptic transmission, GABAergic (GO:0032228) | 3.26673482 |
| 100 | female mating behavior (GO:0060180) | 3.26526459 |
| 101 | positive regulation of dendritic spine development (GO:0060999) | 3.26320436 |
| 102 | regulation of vesicle fusion (GO:0031338) | 3.25218031 |
| 103 | visual behavior (GO:0007632) | 3.25004711 |
| 104 | phospholipase C-activating dopamine receptor signaling pathway (GO:0060158) | 3.24973519 |
| 105 | negative regulation of dendrite morphogenesis (GO:0050774) | 3.24068193 |
| 106 | mating behavior (GO:0007617) | 3.23673311 |
| 107 | cell adhesion mediated by integrin (GO:0033627) | 3.22849994 |
| 108 | negative regulation of dendrite development (GO:2000171) | 3.21531551 |
| 109 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.21308091 |
| 110 | adherens junction assembly (GO:0034333) | 3.20849488 |
| 111 | glycine transport (GO:0015816) | 3.19459114 |
| 112 | neuromuscular process controlling posture (GO:0050884) | 3.14386481 |
| 113 | membrane depolarization during action potential (GO:0086010) | 3.11376490 |
| 114 | L-amino acid import (GO:0043092) | 3.07129158 |
| 115 | negative regulation of amino acid transport (GO:0051956) | 3.06648257 |
| 116 | cerebellar granule cell differentiation (GO:0021707) | 3.05905455 |
| 117 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.03307728 |
| 118 | regulation of early endosome to late endosome transport (GO:2000641) | 2.96878623 |
| 119 | negative regulation of keratinocyte proliferation (GO:0010839) | 2.95820311 |
| 120 | cell communication by electrical coupling (GO:0010644) | 2.94659529 |
| 121 | synaptic vesicle endocytosis (GO:0048488) | 2.92081627 |
| 122 | protein complex localization (GO:0031503) | 2.82787990 |
| 123 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 2.79768047 |
| 124 | keratinization (GO:0031424) | 2.79122403 |
| 125 | activation of Rac GTPase activity (GO:0032863) | 2.75966282 |
| 126 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 2.74412390 |
| 127 | cellular protein complex localization (GO:0034629) | 2.71945480 |
| 128 | cell communication involved in cardiac conduction (GO:0086065) | 2.71059227 |
| 129 | skin morphogenesis (GO:0043589) | 2.70092691 |
| 130 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 2.69878225 |
| 131 | postsynaptic membrane organization (GO:0001941) | 2.69517063 |
| 132 | potassium ion homeostasis (GO:0055075) | 2.68152785 |
| 133 | dichotomous subdivision of an epithelial terminal unit (GO:0060600) | 2.61704882 |
| 134 | establishment of skin barrier (GO:0061436) | 2.57587611 |
| 135 | regulation of water loss via skin (GO:0033561) | 2.57503849 |
| 136 | endodermal cell differentiation (GO:0035987) | 2.56044210 |
| 137 | mesodermal cell differentiation (GO:0048333) | 2.55751516 |
| 138 | regulation of epidermal growth factor-activated receptor activity (GO:0007176) | 2.54825871 |
| 139 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 2.54711304 |
| 140 | protein retention in ER lumen (GO:0006621) | 2.54338821 |
| 141 | neuron projection extension (GO:1990138) | 2.50650683 |
| 142 | response to gravity (GO:0009629) | 2.49918440 |
| 143 | dicarboxylic acid transport (GO:0006835) | 2.49266125 |
| 144 | regulation of synapse maturation (GO:0090128) | 2.48840610 |
| 145 | vesicle docking involved in exocytosis (GO:0006904) | 2.48589281 |
| 146 | vesicle docking (GO:0048278) | 2.47734012 |
| 147 | positive regulation of vesicle fusion (GO:0031340) | 2.46953113 |
| 148 | dendritic spine organization (GO:0097061) | 2.45737951 |
| 149 | cell junction assembly (GO:0034329) | 2.45003906 |
| 150 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 2.43571362 |
| 151 | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling | 2.42464075 |
| 152 | regulation of ARF protein signal transduction (GO:0032012) | 2.41426910 |
| 153 | axon extension (GO:0048675) | 2.38593719 |
| 154 | regulation of hair follicle development (GO:0051797) | 2.37974327 |
| 155 | cerebellar Purkinje cell layer development (GO:0021680) | 2.37563806 |
| 156 | heparan sulfate proteoglycan biosynthetic process (GO:0015012) | 2.36556516 |
| 157 | membrane tubulation (GO:0097320) | 2.34383806 |
| 158 | polarized epithelial cell differentiation (GO:0030859) | 2.34360437 |
| 159 | protein targeting to plasma membrane (GO:0072661) | 2.32125144 |
| 160 | cell junction organization (GO:0034330) | 2.31509464 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 8.43350555 |
| 2 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.63180162 |
| 3 | * RARB_27405468_Chip-Seq_BRAIN_Mouse | 4.31166444 |
| 4 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 3.44185871 |
| 5 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.41834032 |
| 6 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 3.33081010 |
| 7 | REST_21632747_ChIP-Seq_MESCs_Mouse | 3.32782928 |
| 8 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.28211955 |
| 9 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.20254277 |
| 10 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.11210808 |
| 11 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 3.09490060 |
| 12 | DROSHA_22980978_ChIP-Seq_HELA_Human | 3.04246288 |
| 13 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.84934930 |
| 14 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.79921664 |
| 15 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.69644703 |
| 16 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.69644703 |
| 17 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.68708287 |
| 18 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.65245732 |
| 19 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.64299761 |
| 20 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 2.46982865 |
| 21 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.46789231 |
| 22 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.45343560 |
| 23 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.43625064 |
| 24 | * SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.43259612 |
| 25 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.35762447 |
| 26 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.35045952 |
| 27 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.34113598 |
| 28 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.29814388 |
| 29 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.26746177 |
| 30 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 2.17543410 |
| 31 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.16506905 |
| 32 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 2.16366734 |
| 33 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.95048208 |
| 34 | * UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.94797764 |
| 35 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.91266347 |
| 36 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.88602209 |
| 37 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.79465777 |
| 38 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.78540385 |
| 39 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.75933864 |
| 40 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.69944699 |
| 41 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.68856809 |
| 42 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.67062875 |
| 43 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.66306149 |
| 44 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.64870873 |
| 45 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.64840839 |
| 46 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.64442148 |
| 47 | * LXR_22292898_ChIP-Seq_THP-1_Human | 1.63972586 |
| 48 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.62427802 |
| 49 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.56034701 |
| 50 | * P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.55073779 |
| 51 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.54980642 |
| 52 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.50923654 |
| 53 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.50845394 |
| 54 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.50845394 |
| 55 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 1.49905211 |
| 56 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.47402354 |
| 57 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.42428589 |
| 58 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.42045448 |
| 59 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.42012894 |
| 60 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.41356104 |
| 61 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.40380286 |
| 62 | * P63_26484246_Chip-Seq_KERATINOCYTES_Human | 1.39716863 |
| 63 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.39181627 |
| 64 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.38383680 |
| 65 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.37818356 |
| 66 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.35955444 |
| 67 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.35565573 |
| 68 | ATF3_27146783_Chip-Seq_COLON_Human | 1.35462562 |
| 69 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.35319248 |
| 70 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.35314772 |
| 71 | TP53_22127205_ChIP-Seq_IMR90_Human | 1.34500088 |
| 72 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.33927070 |
| 73 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.29880632 |
| 74 | * KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.25997594 |
| 75 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.25771390 |
| 76 | * KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.25727970 |
| 77 | UBF1/2_26484160_Chip-Seq_HMECs_Human | 1.25567978 |
| 78 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.24048641 |
| 79 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.23473002 |
| 80 | * SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.23117090 |
| 81 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.22545363 |
| 82 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.20935874 |
| 83 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.20688543 |
| 84 | KDM2B_26808549_Chip-Seq_K562_Human | 1.20678501 |
| 85 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 1.19284957 |
| 86 | TP53_23651856_ChIP-Seq_MEFs_Mouse | 1.17171268 |
| 87 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.15124218 |
| 88 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.12400865 |
| 89 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.11741645 |
| 90 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.10510247 |
| 91 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.09601797 |
| 92 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.09096092 |
| 93 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.08635202 |
| 94 | AR_19668381_ChIP-Seq_PC3_Human | 1.08029866 |
| 95 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.07215274 |
| 96 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.06686094 |
| 97 | P300_19829295_ChIP-Seq_ESCs_Human | 1.05897398 |
| 98 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.05580384 |
| 99 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.05543321 |
| 100 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.05357932 |
| 101 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.05214606 |
| 102 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.04727737 |
| 103 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.04483339 |
| 104 | * TP63_22573176_ChIP-Seq_HFKS_Human | 1.03765994 |
| 105 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.02510234 |
| 106 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.01854931 |
| 107 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.01812679 |
| 108 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 1.01317870 |
| 109 | AR_25329375_ChIP-Seq_VCAP_Human | 1.00752895 |
| 110 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.00203515 |
| 111 | STAT3_23295773_ChIP-Seq_U87_Human | 0.99955351 |
| 112 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.99849486 |
| 113 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.99417297 |
| 114 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.99376347 |
| 115 | TCF4_23295773_ChIP-Seq_U87_Human | 0.98206779 |
| 116 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.96803709 |
| 117 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.96313947 |
| 118 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.96215233 |
| 119 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 0.95453645 |
| 120 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.94914318 |
| 121 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 0.94638903 |
| 122 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.94195073 |
| 123 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.93234860 |
| 124 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.92749539 |
| 125 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.92191538 |
| 126 | * SA1_27219007_Chip-Seq_ERYTHROID_Human | 0.92112132 |
| 127 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 0.91385308 |
| 128 | SETDB1_19884255_ChIP-Seq_MESCs_Mouse | 0.91104908 |
| 129 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.91010563 |
| 130 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 0.89701426 |
| 131 | P68_20966046_ChIP-Seq_HELA_Human | 0.89701163 |
| 132 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 0.88657756 |
| 133 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.88445025 |
| 134 | TFAP2A_17053090_ChIP-ChIP_MCF-7_Human | 0.87857116 |
| 135 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 0.87345010 |
| 136 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.86722997 |
| 137 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 0.86715744 |
| 138 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.85814687 |
| 139 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.85698658 |
| 140 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 0.85535510 |
| 141 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.85325967 |
| 142 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.85025597 |
| 143 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 0.84351221 |
| 144 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.81625391 |
| 145 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.81578627 |
| 146 | DPY_21335234_ChIP-Seq_ESCs_Mouse | 0.78389984 |
| 147 | SPI1_23127762_ChIP-Seq_K562_Human | 0.78382260 |
| 148 | JUN_21703547_ChIP-Seq_K562_Human | 0.78253726 |
| 149 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.78171905 |
| 150 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.76118268 |
| 151 | KLF4_19829295_ChIP-Seq_ESCs_Human | 0.75278774 |
| 152 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.74988863 |
| 153 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.74818014 |
| 154 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.74419960 |
| 155 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.73023464 |
| 156 | OCT4_19829295_ChIP-Seq_ESCs_Human | 0.71584448 |
| 157 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 0.71518668 |
| 158 | SMAD4_21741376_ChIP-Seq_ESCs_Human | 0.69650342 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 6.72205594 |
| 2 | MP0002822_catalepsy | 6.10273527 |
| 3 | MP0000579_abnormal_nail_morphology | 5.03625762 |
| 4 | MP0003880_abnormal_central_pattern | 4.84414749 |
| 5 | MP0003635_abnormal_synaptic_transmissio | 4.30127375 |
| 6 | MP0009745_abnormal_behavioral_response | 3.75949723 |
| 7 | MP0002063_abnormal_learning/memory/cond | 3.50243403 |
| 8 | MP0002064_seizures | 3.25106208 |
| 9 | MP0004270_analgesia | 3.13324750 |
| 10 | MP0003705_abnormal_hypodermis_morpholog | 3.13066139 |
| 11 | MP0003941_abnormal_skin_development | 3.07666815 |
| 12 | MP0009046_muscle_twitch | 3.02784302 |
| 13 | MP0001968_abnormal_touch/_nociception | 2.99380557 |
| 14 | MP0002572_abnormal_emotion/affect_behav | 2.89484979 |
| 15 | MP0005423_abnormal_somatic_nervous | 2.77934029 |
| 16 | MP0002272_abnormal_nervous_system | 2.73557753 |
| 17 | MP0001486_abnormal_startle_reflex | 2.68599946 |
| 18 | MP0001529_abnormal_vocalization | 2.59049214 |
| 19 | MP0005623_abnormal_meninges_morphology | 2.51420543 |
| 20 | MP0003566_abnormal_cell_adhesion | 2.49892586 |
| 21 | MP0000762_abnormal_tongue_morphology | 2.44030654 |
| 22 | MP0001501_abnormal_sleep_pattern | 2.39088393 |
| 23 | MP0002736_abnormal_nociception_after | 2.29223966 |
| 24 | MP0002734_abnormal_mechanical_nocicepti | 2.26143903 |
| 25 | MP0002909_abnormal_adrenal_gland | 2.17102268 |
| 26 | MP0002796_impaired_skin_barrier | 2.13734529 |
| 27 | MP0004272_abnormal_basement_membrane | 2.12555118 |
| 28 | MP0001849_ear_inflammation | 2.04089492 |
| 29 | MP0005646_abnormal_pituitary_gland | 1.99200678 |
| 30 | MP0001970_abnormal_pain_threshold | 1.94759675 |
| 31 | MP0008569_lethality_at_weaning | 1.91606464 |
| 32 | MP0002735_abnormal_chemical_nociception | 1.88379803 |
| 33 | MP0004924_abnormal_behavior | 1.85329792 |
| 34 | MP0005386_behavior/neurological_phenoty | 1.85329792 |
| 35 | MP0001299_abnormal_eye_distance/ | 1.83708129 |
| 36 | MP0002733_abnormal_thermal_nociception | 1.82838134 |
| 37 | MP0000467_abnormal_esophagus_morphology | 1.81878298 |
| 38 | MP0003879_abnormal_hair_cell | 1.79538101 |
| 39 | MP0001440_abnormal_grooming_behavior | 1.76630355 |
| 40 | MP0000537_abnormal_urethra_morphology | 1.75115069 |
| 41 | MP0005409_darkened_coat_color | 1.74675820 |
| 42 | MP0004811_abnormal_neuron_physiology | 1.72997861 |
| 43 | MP0002067_abnormal_sensory_capabilities | 1.70101153 |
| 44 | MP0002557_abnormal_social/conspecific_i | 1.68545117 |
| 45 | MP0000566_synostosis | 1.67138231 |
| 46 | MP0002060_abnormal_skin_morphology | 1.66571677 |
| 47 | MP0001188_hyperpigmentation | 1.65699819 |
| 48 | MP0009780_abnormal_chondrocyte_physiolo | 1.58487579 |
| 49 | MP0002234_abnormal_pharynx_morphology | 1.57935915 |
| 50 | MP0001984_abnormal_olfaction | 1.56679430 |
| 51 | MP0005501_abnormal_skin_physiology | 1.48997753 |
| 52 | MP0009053_abnormal_anal_canal | 1.48773457 |
| 53 | MP0001905_abnormal_dopamine_level | 1.46236454 |
| 54 | MP0005257_abnormal_intraocular_pressure | 1.45919384 |
| 55 | MP0003453_abnormal_keratinocyte_physiol | 1.43439574 |
| 56 | MP0005275_abnormal_skin_tensile | 1.38948862 |
| 57 | MP0003075_altered_response_to | 1.38701038 |
| 58 | MP0003329_amyloid_beta_deposits | 1.38429345 |
| 59 | MP0001348_abnormal_lacrimal_gland | 1.38059702 |
| 60 | MP0002089_abnormal_postnatal_growth/wei | 1.35614774 |
| 61 | MP0005023_abnormal_wound_healing | 1.33984970 |
| 62 | MP0002184_abnormal_innervation | 1.33423164 |
| 63 | MP0003950_abnormal_plasma_membrane | 1.32837716 |
| 64 | MP0002066_abnormal_motor_capabilities/c | 1.32256575 |
| 65 | MP0010771_integument_phenotype | 1.31473693 |
| 66 | MP0003633_abnormal_nervous_system | 1.30805921 |
| 67 | MP0008438_abnormal_cutaneous_collagen | 1.29989654 |
| 68 | MP0008874_decreased_physiological_sensi | 1.29442549 |
| 69 | MP0005645_abnormal_hypothalamus_physiol | 1.28359685 |
| 70 | MP0008872_abnormal_physiological_respon | 1.28335382 |
| 71 | MP0003787_abnormal_imprinting | 1.26601422 |
| 72 | MP0000955_abnormal_spinal_cord | 1.25152562 |
| 73 | MP0001502_abnormal_circadian_rhythm | 1.24153197 |
| 74 | MP0004142_abnormal_muscle_tone | 1.23906928 |
| 75 | MP0008260_abnormal_autophagy | 1.23735268 |
| 76 | MP0001216_abnormal_epidermal_layer | 1.21694021 |
| 77 | MP0000678_abnormal_parathyroid_gland | 1.17191709 |
| 78 | MP0002882_abnormal_neuron_morphology | 1.16160095 |
| 79 | MP0008961_abnormal_basal_metabolism | 1.15860463 |
| 80 | MP0006276_abnormal_autonomic_nervous | 1.13704265 |
| 81 | MP0004885_abnormal_endolymph | 1.10888956 |
| 82 | MP0003123_paternal_imprinting | 1.10175815 |
| 83 | MP0000013_abnormal_adipose_tissue | 1.07896077 |
| 84 | MP0001346_abnormal_lacrimal_gland | 1.06459803 |
| 85 | MP0010030_abnormal_orbit_morphology | 1.02913905 |
| 86 | MP0004858_abnormal_nervous_system | 1.02853138 |
| 87 | MP0003183_abnormal_peptide_metabolism | 1.01918571 |
| 88 | MP0003631_nervous_system_phenotype | 1.00222355 |
| 89 | MP0005535_abnormal_body_temperature | 0.93601821 |
| 90 | MP0002069_abnormal_eating/drinking_beha | 0.92831701 |
| 91 | MP0010678_abnormal_skin_adnexa | 0.91961923 |
| 92 | MP0003091_abnormal_cell_migration | 0.88573025 |
| 93 | MP0010352_gastrointestinal_tract_polyps | 0.88421181 |
| 94 | MP0000534_abnormal_ureter_morphology | 0.88181602 |
| 95 | MP0010368_abnormal_lymphatic_system | 0.87713544 |
| 96 | MP0001177_atelectasis | 0.87172349 |
| 97 | MP0000778_abnormal_nervous_system | 0.85974211 |
| 98 | MP0003172_abnormal_lysosome_physiology | 0.84308186 |
| 99 | MP0002098_abnormal_vibrissa_morphology | 0.84248360 |
| 100 | MP0002229_neurodegeneration | 0.84146143 |
| 101 | MP0002152_abnormal_brain_morphology | 0.83497080 |
| 102 | MP0000003_abnormal_adipose_tissue | 0.83257466 |
| 103 | MP0003385_abnormal_body_wall | 0.82014066 |
| 104 | MP0004085_abnormal_heartbeat | 0.81711372 |
| 105 | MP0003755_abnormal_palate_morphology | 0.79940061 |
| 106 | MP0009672_abnormal_birth_weight | 0.79327725 |
| 107 | MP0005551_abnormal_eye_electrophysiolog | 0.78567393 |
| 108 | MP0000751_myopathy | 0.75579300 |
| 109 | MP0001340_abnormal_eyelid_morphology | 0.74815680 |
| 110 | MP0005499_abnormal_olfactory_system | 0.74201046 |
| 111 | MP0005394_taste/olfaction_phenotype | 0.74201046 |
| 112 | MP0003861_abnormal_nervous_system | 0.73884159 |
| 113 | MP0001958_emphysema | 0.73506436 |
| 114 | MP0005167_abnormal_blood-brain_barrier | 0.73034379 |
| 115 | MP0002638_abnormal_pupillary_reflex | 0.72395200 |
| 116 | MP0002697_abnormal_eye_size | 0.71624287 |
| 117 | MP0003315_abnormal_perineum_morphology | 0.71485506 |
| 118 | MP0003690_abnormal_glial_cell | 0.71141299 |
| 119 | MP0010386_abnormal_urinary_bladder | 0.70625627 |
| 120 | MP0001664_abnormal_digestion | 0.69583191 |
| 121 | MP0002090_abnormal_vision | 0.68680691 |
| 122 | MP0000428_abnormal_craniofacial_morphol | 0.67657875 |
| 123 | MP0000733_abnormal_muscle_development | 0.67477009 |
| 124 | MP0003122_maternal_imprinting | 0.67152925 |
| 125 | MP0003303_peritoneal_inflammation | 0.66768623 |
| 126 | MP0002877_abnormal_melanocyte_morpholog | 0.66736067 |
| 127 | MP0000377_abnormal_hair_follicle | 0.66691254 |
| 128 | MP0000569_abnormal_digit_pigmentation | 0.66075487 |
| 129 | MP0000631_abnormal_neuroendocrine_gland | 0.65773551 |
| 130 | MP0000920_abnormal_myelination | 0.64239964 |
| 131 | MP0002081_perinatal_lethality | 0.64140499 |
| 132 | MP0008877_abnormal_DNA_methylation | 0.63224464 |
| 133 | MP0002177_abnormal_outer_ear | 0.62024619 |
| 134 | MP0004233_abnormal_muscle_weight | 0.60450993 |
| 135 | MP0002896_abnormal_bone_mineralization | 0.60213706 |
| 136 | MP0001963_abnormal_hearing_physiology | 0.60150901 |
| 137 | MP0000462_abnormal_digestive_system | 0.59054371 |
| 138 | MP0000604_amyloidosis | 0.56904553 |
| 139 | MP0001485_abnormal_pinna_reflex | 0.56340629 |
| 140 | MP0010234_abnormal_vibrissa_follicle | 0.53969955 |
| 141 | MP0005166_decreased_susceptibility_to | 0.53009141 |
| 142 | MP0004742_abnormal_vestibular_system | 0.50746308 |
| 143 | MP0003956_abnormal_body_size | 0.50532201 |
| 144 | MP0003634_abnormal_glial_cell | 0.48333493 |
| 145 | MP0003866_abnormal_defecation | 0.48055280 |
| 146 | MP0005174_abnormal_tail_pigmentation | 0.47779408 |
| 147 | MP0002396_abnormal_hematopoietic_system | 0.47522725 |
| 148 | MP0003632_abnormal_nervous_system | 0.45502409 |
| 149 | MP0001943_abnormal_respiration | 0.45001302 |
| 150 | MP0005310_abnormal_salivary_gland | 0.44763689 |
| 151 | MP0002876_abnormal_thyroid_physiology | 0.43953987 |
| 152 | MP0003283_abnormal_digestive_organ | 0.43438744 |
| 153 | MP0010769_abnormal_survival | 0.42217918 |
| 154 | MP0001986_abnormal_taste_sensitivity | 0.42088425 |
| 155 | MP0002752_abnormal_somatic_nervous | 0.42035428 |
| 156 | MP0001765_abnormal_ion_homeostasis | 0.40854648 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 8.30239212 |
| 2 | Myokymia (HP:0002411) | 8.25337032 |
| 3 | Focal seizures (HP:0007359) | 5.89833249 |
| 4 | Milia (HP:0001056) | 5.53921319 |
| 5 | Visual hallucinations (HP:0002367) | 5.40398503 |
| 6 | Atrophic scars (HP:0001075) | 5.18437013 |
| 7 | Fragile nails (HP:0001808) | 5.12887295 |
| 8 | Abnormality of nail color (HP:0100643) | 4.92805281 |
| 9 | Onycholysis (HP:0001806) | 4.72618795 |
| 10 | Epileptic encephalopathy (HP:0200134) | 4.68440067 |
| 11 | Papilledema (HP:0001085) | 4.60442419 |
| 12 | Febrile seizures (HP:0002373) | 4.39205480 |
| 13 | Atonic seizures (HP:0010819) | 4.20729195 |
| 14 | Plantar hyperkeratosis (HP:0007556) | 4.16391888 |
| 15 | Poor eye contact (HP:0000817) | 4.12806083 |
| 16 | Absence seizures (HP:0002121) | 4.10975806 |
| 17 | Thick nail (HP:0001805) | 4.08588636 |
| 18 | Generalized tonic-clonic seizures (HP:0002069) | 3.80517622 |
| 19 | Dialeptic seizures (HP:0011146) | 3.78983806 |
| 20 | Broad-based gait (HP:0002136) | 3.78921542 |
| 21 | Depression (HP:0000716) | 3.72704992 |
| 22 | Annular pancreas (HP:0001734) | 3.72010253 |
| 23 | Impaired vibration sensation in the lower limbs (HP:0002166) | 3.56510803 |
| 24 | Anxiety (HP:0000739) | 3.54151120 |
| 25 | Ankle clonus (HP:0011448) | 3.54038762 |
| 26 | Gaze-evoked nystagmus (HP:0000640) | 3.53367607 |
| 27 | Neurofibrillary tangles (HP:0002185) | 3.52047189 |
| 28 | Impaired social interactions (HP:0000735) | 3.51199398 |
| 29 | Abnormal social behavior (HP:0012433) | 3.51199398 |
| 30 | Torticollis (HP:0000473) | 3.48340059 |
| 31 | Cerebral inclusion bodies (HP:0100314) | 3.39025501 |
| 32 | Resting tremor (HP:0002322) | 3.38696403 |
| 33 | Progressive cerebellar ataxia (HP:0002073) | 3.38379482 |
| 34 | Nail dystrophy (HP:0008404) | 3.34324833 |
| 35 | Action tremor (HP:0002345) | 3.26115787 |
| 36 | Focal dystonia (HP:0004373) | 3.25221168 |
| 37 | Stereotypic behavior (HP:0000733) | 3.21724715 |
| 38 | Truncal ataxia (HP:0002078) | 3.20700445 |
| 39 | Urinary bladder sphincter dysfunction (HP:0002839) | 3.19990545 |
| 40 | Postural instability (HP:0002172) | 3.16908508 |
| 41 | Supranuclear gaze palsy (HP:0000605) | 3.15230654 |
| 42 | Dysdiadochokinesis (HP:0002075) | 3.14477277 |
| 43 | Impaired smooth pursuit (HP:0007772) | 3.13730847 |
| 44 | Fragile skin (HP:0001030) | 3.07239745 |
| 45 | Craniofacial dystonia (HP:0012179) | 3.06790962 |
| 46 | Abnormal eating behavior (HP:0100738) | 3.03808114 |
| 47 | Acute lymphatic leukemia (HP:0006721) | 3.03405425 |
| 48 | Ankyloglossia (HP:0010296) | 3.02691393 |
| 49 | Premature rupture of membranes (HP:0001788) | 2.95458135 |
| 50 | Selective tooth agenesis (HP:0001592) | 2.93935691 |
| 51 | Dysmetria (HP:0001310) | 2.93835637 |
| 52 | Palmoplantar hyperkeratosis (HP:0000972) | 2.92713540 |
| 53 | Upper limb amyotrophy (HP:0009129) | 2.90852175 |
| 54 | Distal upper limb amyotrophy (HP:0007149) | 2.90852175 |
| 55 | Alopecia of scalp (HP:0002293) | 2.90199532 |
| 56 | Scanning speech (HP:0002168) | 2.90020398 |
| 57 | Urinary urgency (HP:0000012) | 2.90009666 |
| 58 | Bradykinesia (HP:0002067) | 2.85558240 |
| 59 | Ridged nail (HP:0001807) | 2.83267386 |
| 60 | Pointed chin (HP:0000307) | 2.80871036 |
| 61 | Amblyopia (HP:0000646) | 2.78918334 |
| 62 | Dysmetric saccades (HP:0000641) | 2.74905490 |
| 63 | Distal lower limb amyotrophy (HP:0008944) | 2.74664033 |
| 64 | Palmar hyperkeratosis (HP:0010765) | 2.71431093 |
| 65 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.60863011 |
| 66 | Abnormality of the lower motor neuron (HP:0002366) | 2.60361411 |
| 67 | Spastic gait (HP:0002064) | 2.54628070 |
| 68 | Mutism (HP:0002300) | 2.51982680 |
| 69 | Abnormality of oral frenula (HP:0000190) | 2.51042657 |
| 70 | Hyperventilation (HP:0002883) | 2.50064545 |
| 71 | Abnormal blistering of the skin (HP:0008066) | 2.46224022 |
| 72 | Protrusio acetabuli (HP:0003179) | 2.45228015 |
| 73 | Polygenic inheritance (HP:0010982) | 2.43338519 |
| 74 | Spinal canal stenosis (HP:0003416) | 2.41422181 |
| 75 | Hand muscle atrophy (HP:0009130) | 2.41263464 |
| 76 | Impaired vibratory sensation (HP:0002495) | 2.39964775 |
| 77 | Difficulty climbing stairs (HP:0003551) | 2.38443451 |
| 78 | Limb dystonia (HP:0002451) | 2.38421533 |
| 79 | Shallow orbits (HP:0000586) | 2.38280186 |
| 80 | Natal tooth (HP:0000695) | 2.36309319 |
| 81 | Diplopia (HP:0000651) | 2.34111663 |
| 82 | Abnormality of binocular vision (HP:0011514) | 2.34111663 |
| 83 | Hypoplasia of dental enamel (HP:0006297) | 2.32789258 |
| 84 | Hemiplegia (HP:0002301) | 2.30665039 |
| 85 | Hyperacusis (HP:0010780) | 2.30118000 |
| 86 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 2.29101299 |
| 87 | Progressive inability to walk (HP:0002505) | 2.23239200 |
| 88 | Pterygium (HP:0001059) | 2.22914703 |
| 89 | Intention tremor (HP:0002080) | 2.20110681 |
| 90 | Insomnia (HP:0100785) | 2.19818338 |
| 91 | Lower limb amyotrophy (HP:0007210) | 2.19768197 |
| 92 | Epileptiform EEG discharges (HP:0011182) | 2.17459694 |
| 93 | Aplasia involving bones of the upper limbs (HP:0009823) | 2.16078403 |
| 94 | Aplasia of the phalanges of the hand (HP:0009802) | 2.16078403 |
| 95 | Aplasia involving bones of the extremities (HP:0009825) | 2.16078403 |
| 96 | Abnormality of saccadic eye movements (HP:0000570) | 2.12843945 |
| 97 | Achilles tendon contracture (HP:0001771) | 2.11710058 |
| 98 | Clonus (HP:0002169) | 2.11589278 |
| 99 | Coronal craniosynostosis (HP:0004440) | 2.10960099 |
| 100 | Abnormal EKG (HP:0003115) | 2.09252917 |
| 101 | Ulnar bowing (HP:0003031) | 2.09191439 |
| 102 | Ankle contracture (HP:0006466) | 2.08602268 |
| 103 | Hemiparesis (HP:0001269) | 2.08023001 |
| 104 | Status epilepticus (HP:0002133) | 2.07339173 |
| 105 | Incomplete penetrance (HP:0003829) | 2.06370153 |
| 106 | EEG with generalized epileptiform discharges (HP:0011198) | 2.06292900 |
| 107 | Genetic anticipation (HP:0003743) | 2.04573612 |
| 108 | Iris hypopigmentation (HP:0007730) | 2.04269071 |
| 109 | Short nail (HP:0001799) | 2.04169156 |
| 110 | Follicular hyperkeratosis (HP:0007502) | 2.04104997 |
| 111 | Rigidity (HP:0002063) | 2.01379148 |
| 112 | Abnormality of the salivary glands (HP:0010286) | 1.99985673 |
| 113 | Arterial tortuosity (HP:0005116) | 1.98316458 |
| 114 | Lower limb asymmetry (HP:0100559) | 1.96208637 |
| 115 | Split foot (HP:0001839) | 1.95615747 |
| 116 | Ventricular fibrillation (HP:0001663) | 1.94594101 |
| 117 | Pili torti (HP:0003777) | 1.93604064 |
| 118 | Gait ataxia (HP:0002066) | 1.93248459 |
| 119 | Spinal rigidity (HP:0003306) | 1.92577722 |
| 120 | Right ventricular cardiomyopathy (HP:0011663) | 1.92442594 |
| 121 | Obstructive sleep apnea (HP:0002870) | 1.91331981 |
| 122 | Fetal akinesia sequence (HP:0001989) | 1.91116058 |
| 123 | Limb ataxia (HP:0002070) | 1.90487033 |
| 124 | Hypsarrhythmia (HP:0002521) | 1.89987590 |
| 125 | Neuronal loss in central nervous system (HP:0002529) | 1.89985267 |
| 126 | Psychosis (HP:0000709) | 1.89157841 |
| 127 | Megalencephaly (HP:0001355) | 1.88259076 |
| 128 | Bronchomalacia (HP:0002780) | 1.88126560 |
| 129 | Vascular tortuosity (HP:0004948) | 1.87959208 |
| 130 | Inability to walk (HP:0002540) | 1.83598950 |
| 131 | Drooling (HP:0002307) | 1.83587061 |
| 132 | Excessive salivation (HP:0003781) | 1.83587061 |
| 133 | Ocular albinism (HP:0001107) | 1.82576105 |
| 134 | Lower limb muscle weakness (HP:0007340) | 1.82345091 |
| 135 | Abnormality of the periventricular white matter (HP:0002518) | 1.80882672 |
| 136 | Advanced eruption of teeth (HP:0006288) | 1.79260814 |
| 137 | Abnormality of the Achilles tendon (HP:0005109) | 1.77575173 |
| 138 | Generalized myoclonic seizures (HP:0002123) | 1.77198313 |
| 139 | Sparse scalp hair (HP:0002209) | 1.76435271 |
| 140 | Protruding tongue (HP:0010808) | 1.75449277 |
| 141 | Broad metatarsal (HP:0001783) | 1.75343287 |
| 142 | Generalized hypotonia (HP:0001290) | 1.74563678 |
| 143 | Vertebral arch anomaly (HP:0008438) | 1.74547916 |
| 144 | Polyphagia (HP:0002591) | 1.74201236 |
| 145 | Delusions (HP:0000746) | 1.72620091 |
| 146 | Unsteady gait (HP:0002317) | 1.72239228 |
| 147 | Chronic otitis media (HP:0000389) | 1.70394542 |
| 148 | Inappropriate behavior (HP:0000719) | 1.69994163 |
| 149 | Hydroureter (HP:0000072) | 1.69765997 |
| 150 | Sparse eyelashes (HP:0000653) | 1.69537405 |
| 151 | Absent speech (HP:0001344) | 1.69519457 |
| 152 | Prolonged QT interval (HP:0001657) | 1.68886982 |
| 153 | Apathy (HP:0000741) | 1.68788673 |
| 154 | Deep palmar crease (HP:0006191) | 1.67938871 |
| 155 | Bladder diverticulum (HP:0000015) | 1.65701823 |
| 156 | Spinal cord compression (HP:0002176) | 1.65591133 |
| 157 | Turricephaly (HP:0000262) | 1.64367273 |
| 158 | Long palpebral fissure (HP:0000637) | 1.64020586 |
| 159 | Distal lower limb muscle weakness (HP:0009053) | 1.63706756 |
| 160 | Cerebral hypomyelination (HP:0006808) | 1.62784683 |
| 161 | Oral leukoplakia (HP:0002745) | 1.61907908 |
| 162 | Distal sensory impairment (HP:0002936) | 1.61003728 |
| 163 | Diminished motivation (HP:0000745) | 1.60413201 |
| 164 | Arnold-Chiari malformation (HP:0002308) | 1.60362684 |
| 165 | Termporal pattern (HP:0011008) | 1.59408209 |
| 166 | Insidious onset (HP:0003587) | 1.59408209 |
| 167 | Wormian bones (HP:0002645) | 1.59362348 |
| 168 | Tetraplegia (HP:0002445) | 1.59027712 |
| 169 | Vertebral compression fractures (HP:0002953) | 1.56408972 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHA4 | 6.30047839 |
| 2 | NTRK3 | 4.25176324 |
| 3 | MAP3K9 | 3.46664873 |
| 4 | RIPK4 | 3.41500435 |
| 5 | LATS2 | 3.25536743 |
| 6 | EPHA2 | 2.78375758 |
| 7 | DAPK2 | 2.61804589 |
| 8 | FES | 2.58757018 |
| 9 | MINK1 | 2.48258616 |
| 10 | CAMKK1 | 2.47873690 |
| 11 | MAP3K12 | 2.47684169 |
| 12 | MAP3K4 | 2.42681624 |
| 13 | KSR2 | 2.27946872 |
| 14 | DAPK1 | 2.26481002 |
| 15 | MST1R | 2.23560916 |
| 16 | PRKD3 | 2.15584872 |
| 17 | MAP2K7 | 2.12703775 |
| 18 | PTK2 | 2.10744308 |
| 19 | TNIK | 2.10353230 |
| 20 | ARAF | 2.04594841 |
| 21 | CDK19 | 2.02302507 |
| 22 | MET | 1.99608025 |
| 23 | MAP3K13 | 1.95512711 |
| 24 | PDGFRA | 1.86511914 |
| 25 | CAMKK2 | 1.83719528 |
| 26 | SIK2 | 1.81670410 |
| 27 | NTRK2 | 1.79699834 |
| 28 | TRIB3 | 1.67441075 |
| 29 | CDK5 | 1.56757035 |
| 30 | RAF1 | 1.49558529 |
| 31 | PAK6 | 1.47459017 |
| 32 | MAP2K4 | 1.44509322 |
| 33 | NTRK1 | 1.44459103 |
| 34 | MARK1 | 1.43824726 |
| 35 | TESK1 | 1.43573954 |
| 36 | PAK4 | 1.41539545 |
| 37 | KSR1 | 1.41183723 |
| 38 | EPHB2 | 1.36391757 |
| 39 | TAOK1 | 1.35509289 |
| 40 | TTN | 1.29761992 |
| 41 | LIMK1 | 1.24153488 |
| 42 | PRPF4B | 1.20312819 |
| 43 | PAK2 | 1.13830020 |
| 44 | SIK1 | 1.13376170 |
| 45 | MOS | 1.12294729 |
| 46 | CAMK1 | 1.08612945 |
| 47 | TNK2 | 1.07441022 |
| 48 | PIM2 | 1.06364318 |
| 49 | IRAK3 | 1.05618437 |
| 50 | MAP3K2 | 1.04232805 |
| 51 | SCYL2 | 1.02998553 |
| 52 | BMPR2 | 1.02449350 |
| 53 | SMG1 | 1.01183263 |
| 54 | MAPK13 | 1.01173885 |
| 55 | PLK2 | 1.00963862 |
| 56 | ICK | 1.00329189 |
| 57 | UHMK1 | 0.98114062 |
| 58 | PRKCG | 0.95177132 |
| 59 | ROCK2 | 0.94770013 |
| 60 | ERBB4 | 0.94079255 |
| 61 | LMTK2 | 0.93238678 |
| 62 | BRSK1 | 0.91943188 |
| 63 | NEK1 | 0.87661166 |
| 64 | GRK5 | 0.86876854 |
| 65 | CDK18 | 0.85697293 |
| 66 | CASK | 0.85589946 |
| 67 | CAMK2G | 0.83613525 |
| 68 | CDK15 | 0.82784173 |
| 69 | PRKG2 | 0.82474491 |
| 70 | STK11 | 0.82180709 |
| 71 | CCNB1 | 0.76947229 |
| 72 | CDK14 | 0.76845894 |
| 73 | BMX | 0.76352112 |
| 74 | MAP3K1 | 0.75775638 |
| 75 | PDK1 | 0.75305264 |
| 76 | SIK3 | 0.75241598 |
| 77 | STK38 | 0.74936588 |
| 78 | CDK11A | 0.74615978 |
| 79 | MYLK | 0.73356274 |
| 80 | SGK2 | 0.72870163 |
| 81 | SGK494 | 0.71765955 |
| 82 | SGK223 | 0.71765955 |
| 83 | MARK2 | 0.71074001 |
| 84 | ALK | 0.69657517 |
| 85 | LATS1 | 0.69343387 |
| 86 | TAOK2 | 0.69127278 |
| 87 | TYRO3 | 0.67657474 |
| 88 | PTK2B | 0.67359838 |
| 89 | RET | 0.67349858 |
| 90 | PRKCH | 0.66841191 |
| 91 | PNCK | 0.66404244 |
| 92 | KIT | 0.66066835 |
| 93 | PDPK1 | 0.64943463 |
| 94 | PINK1 | 0.64765528 |
| 95 | CAMK2A | 0.64178801 |
| 96 | ADRBK2 | 0.62166578 |
| 97 | SGK1 | 0.61577044 |
| 98 | SGK3 | 0.61200085 |
| 99 | BUB1 | 0.59194492 |
| 100 | CDK12 | 0.59064790 |
| 101 | CAMK2B | 0.58653918 |
| 102 | ABL2 | 0.58399774 |
| 103 | SYK | 0.57704863 |
| 104 | ROCK1 | 0.57170020 |
| 105 | BRAF | 0.55875921 |
| 106 | PAK1 | 0.52422832 |
| 107 | IRAK2 | 0.51825707 |
| 108 | AURKA | 0.49194175 |
| 109 | CAMK4 | 0.48614638 |
| 110 | DYRK1A | 0.48312981 |
| 111 | MTOR | 0.48242854 |
| 112 | NME1 | 0.47908625 |
| 113 | FLT3 | 0.47773396 |
| 114 | DAPK3 | 0.46794790 |
| 115 | ILK | 0.46729062 |
| 116 | TSSK6 | 0.46703411 |
| 117 | DDR2 | 0.46284588 |
| 118 | DMPK | 0.45698198 |
| 119 | MAP3K6 | 0.45523814 |
| 120 | RIPK1 | 0.44957339 |
| 121 | RPS6KA3 | 0.44881222 |
| 122 | PHKG1 | 0.44719868 |
| 123 | PHKG2 | 0.44719868 |
| 124 | PDGFRB | 0.42375961 |
| 125 | MAP3K8 | 0.42347916 |
| 126 | FYN | 0.40486983 |
| 127 | NME2 | 0.39869601 |
| 128 | RPS6KA2 | 0.39852515 |
| 129 | MAPK10 | 0.36671922 |
| 130 | EEF2K | 0.35330659 |
| 131 | MAP3K7 | 0.34390271 |
| 132 | MAPKAPK5 | 0.34116908 |
| 133 | PRKCZ | 0.31973000 |
| 134 | HCK | 0.31367600 |
| 135 | PRKCB | 0.30292267 |
| 136 | MUSK | 0.29920779 |
| 137 | GRK6 | 0.29904951 |
| 138 | OXSR1 | 0.29128416 |
| 139 | PRKCA | 0.24960492 |
| 140 | CAMK2D | 0.24257600 |
| 141 | CAMK1G | 0.24045352 |
| 142 | NEK6 | 0.22851972 |
| 143 | PRKCE | 0.22083779 |
| 144 | PRKD2 | 0.21074780 |
| 145 | MAP2K1 | 0.19546723 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Olfactory transduction_Homo sapiens_hsa04740 | 3.63000010 |
| 2 | Nicotine addiction_Homo sapiens_hsa05033 | 3.58790563 |
| 3 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.31622932 |
| 4 | Morphine addiction_Homo sapiens_hsa05032 | 2.92853872 |
| 5 | Circadian entrainment_Homo sapiens_hsa04713 | 2.88980704 |
| 6 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.81102212 |
| 7 | Long-term potentiation_Homo sapiens_hsa04720 | 2.80656039 |
| 8 | GABAergic synapse_Homo sapiens_hsa04727 | 2.79211090 |
| 9 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.66399503 |
| 10 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.63338003 |
| 11 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.43163544 |
| 12 | Cocaine addiction_Homo sapiens_hsa05030 | 2.27132485 |
| 13 | Cholinergic synapse_Homo sapiens_hsa04725 | 2.11141038 |
| 14 | Salivary secretion_Homo sapiens_hsa04970 | 2.10907590 |
| 15 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 2.03762408 |
| 16 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.93366995 |
| 17 | Insulin secretion_Homo sapiens_hsa04911 | 1.90588324 |
| 18 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.87119116 |
| 19 | ECM-receptor interaction_Homo sapiens_hsa04512 | 1.86215142 |
| 20 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.85310972 |
| 21 | Renin secretion_Homo sapiens_hsa04924 | 1.82648838 |
| 22 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.76108283 |
| 23 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.75624616 |
| 24 | Taste transduction_Homo sapiens_hsa04742 | 1.67482316 |
| 25 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.65040465 |
| 26 | Long-term depression_Homo sapiens_hsa04730 | 1.63221582 |
| 27 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.62923461 |
| 28 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.58894923 |
| 29 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.51474475 |
| 30 | Focal adhesion_Homo sapiens_hsa04510 | 1.42420563 |
| 31 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.42135296 |
| 32 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.40792886 |
| 33 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.39696308 |
| 34 | Gap junction_Homo sapiens_hsa04540 | 1.37172560 |
| 35 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.34916357 |
| 36 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.33625786 |
| 37 | Glioma_Homo sapiens_hsa05214 | 1.20439778 |
| 38 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.18175716 |
| 39 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.17107434 |
| 40 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 1.16327669 |
| 41 | Adherens junction_Homo sapiens_hsa04520 | 1.14729322 |
| 42 | Prion diseases_Homo sapiens_hsa05020 | 1.14555712 |
| 43 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.13045492 |
| 44 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.06842600 |
| 45 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.05438188 |
| 46 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.02591799 |
| 47 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.02346962 |
| 48 | Phototransduction_Homo sapiens_hsa04744 | 1.00631006 |
| 49 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.99243481 |
| 50 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.97265474 |
| 51 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.96538838 |
| 52 | Bladder cancer_Homo sapiens_hsa05219 | 0.94955029 |
| 53 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.94579536 |
| 54 | Tight junction_Homo sapiens_hsa04530 | 0.94491802 |
| 55 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.92956783 |
| 56 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.92233416 |
| 57 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.90792535 |
| 58 | Alcoholism_Homo sapiens_hsa05034 | 0.90630633 |
| 59 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.90344572 |
| 60 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.89341408 |
| 61 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.86011923 |
| 62 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.83705822 |
| 63 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.83686818 |
| 64 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.83546772 |
| 65 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.83440134 |
| 66 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.81092191 |
| 67 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.79275869 |
| 68 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.79116175 |
| 69 | Melanogenesis_Homo sapiens_hsa04916 | 0.77627649 |
| 70 | Amoebiasis_Homo sapiens_hsa05146 | 0.77152660 |
| 71 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.76113175 |
| 72 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.74196041 |
| 73 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.73267128 |
| 74 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.72989475 |
| 75 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.72009059 |
| 76 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.71534395 |
| 77 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.70236088 |
| 78 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.69802160 |
| 79 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.69788499 |
| 80 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.68602218 |
| 81 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.67947941 |
| 82 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.67515222 |
| 83 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.66534402 |
| 84 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.66335161 |
| 85 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.64853709 |
| 86 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.62420145 |
| 87 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.62264598 |
| 88 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.61284647 |
| 89 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.61132101 |
| 90 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.60688906 |
| 91 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.60430282 |
| 92 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.59586255 |
| 93 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.58509022 |
| 94 | Melanoma_Homo sapiens_hsa05218 | 0.56050298 |
| 95 | Axon guidance_Homo sapiens_hsa04360 | 0.55480335 |
| 96 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.54189279 |
| 97 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.54151911 |
| 98 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.53457834 |
| 99 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.53345042 |
| 100 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.52625750 |
| 101 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.52106561 |
| 102 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.51211370 |
| 103 | Pathways in cancer_Homo sapiens_hsa05200 | 0.51194063 |
| 104 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.50998207 |
| 105 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.50298656 |
| 106 | Platelet activation_Homo sapiens_hsa04611 | 0.49761407 |
| 107 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.49005842 |
| 108 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.48067760 |
| 109 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.47840752 |
| 110 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.47294726 |
| 111 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.46873846 |
| 112 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.46403530 |
| 113 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.45728601 |
| 114 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.45549887 |
| 115 | Shigellosis_Homo sapiens_hsa05131 | 0.44888092 |
| 116 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.44838431 |
| 117 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.44643249 |
| 118 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.44366920 |
| 119 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.44319794 |
| 120 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.43815663 |
| 121 | Endocytosis_Homo sapiens_hsa04144 | 0.40248663 |
| 122 | Circadian rhythm_Homo sapiens_hsa04710 | 0.38161678 |
| 123 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.36617923 |
| 124 | Thyroid cancer_Homo sapiens_hsa05216 | 0.33720363 |
| 125 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.33345965 |
| 126 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.32174183 |
| 127 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.31353845 |
| 128 | Parkinsons disease_Homo sapiens_hsa05012 | 0.30636378 |
| 129 | Alzheimers disease_Homo sapiens_hsa05010 | 0.29958187 |
| 130 | Endometrial cancer_Homo sapiens_hsa05213 | 0.29248622 |
| 131 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.28361529 |
| 132 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.24994316 |
| 133 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.24098830 |
| 134 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.22088555 |
| 135 | Colorectal cancer_Homo sapiens_hsa05210 | 0.21630765 |

