SH2D6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)8.82588336
2hepatocyte apoptotic process (GO:0097284)7.07212784
3inflammatory response to antigenic stimulus (GO:0002437)6.53256000
4fusion of sperm to egg plasma membrane (GO:0007342)6.51992105
5cell wall macromolecule metabolic process (GO:0044036)6.45366563
6cell wall macromolecule catabolic process (GO:0016998)6.45366563
7production of molecular mediator involved in inflammatory response (GO:0002532)6.45045646
8multicellular organism reproduction (GO:0032504)5.86881549
9detection of chemical stimulus involved in sensory perception of taste (GO:0050912)5.72989239
10sensory perception of taste (GO:0050909)5.59130234
11phosphatidylinositol acyl-chain remodeling (GO:0036149)5.51299989
12otic vesicle formation (GO:0030916)5.36854296
13maintenance of gastrointestinal epithelium (GO:0030277)5.29157271
14sperm motility (GO:0030317)5.12557842
15granulocyte differentiation (GO:0030851)5.07701438
16detection of chemical stimulus involved in sensory perception (GO:0050907)5.01334910
17low-density lipoprotein particle remodeling (GO:0034374)4.96110991
18plasma membrane fusion (GO:0045026)4.80508840
19cilium or flagellum-dependent cell motility (GO:0001539)4.79628084
20reproduction (GO:0000003)4.70988882
21motile cilium assembly (GO:0044458)4.68605623
22sperm-egg recognition (GO:0035036)4.67240284
23phosphatidylserine acyl-chain remodeling (GO:0036150)4.65670040
24acrosome assembly (GO:0001675)4.64792932
25epithelial structure maintenance (GO:0010669)4.64379434
26cell-cell recognition (GO:0009988)4.43122539
27acrosome reaction (GO:0007340)4.38312003
28phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.36262104
29lipoxygenase pathway (GO:0019372)4.31329614
30behavioral response to nicotine (GO:0035095)4.23341942
31arachidonic acid secretion (GO:0050482)4.18139076
32icosanoid secretion (GO:0032309)4.18139076
33response to fungus (GO:0009620)4.16283692
34negative regulation of inclusion body assembly (GO:0090084)4.14536351
35piRNA metabolic process (GO:0034587)4.12551706
36centriole replication (GO:0007099)4.02262938
37axonemal dynein complex assembly (GO:0070286)4.00303249
38response to pheromone (GO:0019236)3.99932294
39indolalkylamine metabolic process (GO:0006586)3.99267691
40detection of light stimulus involved in sensory perception (GO:0050962)3.96628054
41detection of light stimulus involved in visual perception (GO:0050908)3.96628054
42centriole assembly (GO:0098534)3.95678386
43spermatid development (GO:0007286)3.87860493
44fucose catabolic process (GO:0019317)3.86074779
45L-fucose metabolic process (GO:0042354)3.86074779
46L-fucose catabolic process (GO:0042355)3.86074779
47positive regulation of extracellular matrix organization (GO:1903055)3.84945725
48protein K11-linked deubiquitination (GO:0035871)3.80920540
49icosanoid transport (GO:0071715)3.76238246
50fatty acid derivative transport (GO:1901571)3.76238246
51photoreceptor cell differentiation (GO:0046530)3.75929397
52eye photoreceptor cell differentiation (GO:0001754)3.75929397
53phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.74158730
54binding of sperm to zona pellucida (GO:0007339)3.73581318
55epithelial cilium movement (GO:0003351)3.71545066
56sperm capacitation (GO:0048240)3.71244386
57indole-containing compound catabolic process (GO:0042436)3.70309749
58indolalkylamine catabolic process (GO:0046218)3.70309749
59tryptophan catabolic process (GO:0006569)3.70309749
60detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.70109857
61carnitine transmembrane transport (GO:1902603)3.68287076
62cellular ketone body metabolic process (GO:0046950)3.61840092
63intestinal absorption (GO:0050892)3.61389445
64amino-acid betaine transport (GO:0015838)3.60651204
65carnitine transport (GO:0015879)3.60651204
66leukotriene biosynthetic process (GO:0019370)3.58501551
67skin morphogenesis (GO:0043589)3.58314965
68carnitine metabolic process (GO:0009437)3.56779451
69icosanoid biosynthetic process (GO:0046456)3.55999237
70fatty acid derivative biosynthetic process (GO:1901570)3.55999237
71regulation of centriole replication (GO:0046599)3.54917979
72phosphatidic acid metabolic process (GO:0046473)3.53779394
73phosphatidic acid biosynthetic process (GO:0006654)3.53779394
74respiratory chain complex IV assembly (GO:0008535)3.52001858
75single fertilization (GO:0007338)3.51712978
76natural killer cell mediated cytotoxicity (GO:0042267)3.51580130
77natural killer cell mediated immunity (GO:0002228)3.51580130
78negative regulation of interleukin-8 production (GO:0032717)3.48659897
79positive regulation of vesicle fusion (GO:0031340)3.45315043
80ketone body metabolic process (GO:1902224)3.42807811
81cellular response to antibiotic (GO:0071236)3.41789337
82intestinal epithelial cell development (GO:0060576)3.41546783
83cilium movement (GO:0003341)3.38454706
84carnitine shuttle (GO:0006853)3.37579260
85tryptophan metabolic process (GO:0006568)3.35605359
86positive regulation of cellular response to insulin stimulus (GO:1900078)3.34008635
87regulation of Rap GTPase activity (GO:0032317)3.33472192
88photoreceptor cell maintenance (GO:0045494)3.32028196
89positive regulation of oligodendrocyte differentiation (GO:0048714)3.31413649
90phosphatidylcholine acyl-chain remodeling (GO:0036151)3.30658916
91bile acid and bile salt transport (GO:0015721)3.29329491
92male meiosis (GO:0007140)3.27400849
93positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.26378071
94vesicle targeting (GO:0006903)3.25963216
95regulation of glucokinase activity (GO:0033131)3.23074104
96regulation of hexokinase activity (GO:1903299)3.23074104
97regulation of podosome assembly (GO:0071801)3.22008496
98fertilization (GO:0009566)3.21659032
99pyrimidine nucleobase catabolic process (GO:0006208)3.20438427
100neural tube formation (GO:0001841)3.18568087
101bundle of His cell to Purkinje myocyte communication (GO:0086069)3.18422682
102DNA deamination (GO:0045006)3.17974110
103diacylglycerol metabolic process (GO:0046339)3.17767427
104notochord development (GO:0030903)3.16932457
105regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.16410073
106positive regulation of male gonad development (GO:2000020)3.15365686
107phosphatidylserine metabolic process (GO:0006658)3.12699835
108axoneme assembly (GO:0035082)3.11105699
109negative regulation of mast cell activation (GO:0033004)3.10819890
110dopamine transport (GO:0015872)3.09002343
111termination of signal transduction (GO:0023021)3.07536304
112arachidonic acid metabolic process (GO:0019369)3.06779596
113cornea development in camera-type eye (GO:0061303)3.06769813
114alditol phosphate metabolic process (GO:0052646)3.06229066
115kynurenine metabolic process (GO:0070189)3.05905329
116gamma-aminobutyric acid transport (GO:0015812)3.05897753
117prenylation (GO:0097354)3.03744483
118protein prenylation (GO:0018342)3.03744483
119neuronal action potential (GO:0019228)3.03722133
120regulation of cilium movement (GO:0003352)3.03300812
121behavioral response to ethanol (GO:0048149)3.02853254
122nephron tubule formation (GO:0072079)3.01448024
123negative regulation by host of viral transcription (GO:0043922)3.01218558
124synaptonemal complex organization (GO:0070193)2.99741875
125nucleobase catabolic process (GO:0046113)2.99690352
126mitochondrial respiratory chain complex I assembly (GO:0032981)2.99607332
127NADH dehydrogenase complex assembly (GO:0010257)2.99607332
128mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.99607332
129retinal cone cell development (GO:0046549)2.99437566
130sequestering of actin monomers (GO:0042989)2.98749845
131positive regulation of filopodium assembly (GO:0051491)2.98749700
132epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.98387960
133virion attachment to host cell (GO:0019062)2.98352336
134adhesion of symbiont to host cell (GO:0044650)2.98352336
135cardiolipin metabolic process (GO:0032048)2.97403529
136regulation of inclusion body assembly (GO:0090083)2.96139933
137synaptonemal complex assembly (GO:0007130)2.95878606
138photoreceptor cell development (GO:0042461)2.94703003
139cilium morphogenesis (GO:0060271)2.94101970
140polyol catabolic process (GO:0046174)2.93838018
141indole-containing compound metabolic process (GO:0042430)2.93247967
142protein complex biogenesis (GO:0070271)2.92368384
143cAMP catabolic process (GO:0006198)2.92233133
144cytochrome complex assembly (GO:0017004)2.92162496
145proline transport (GO:0015824)2.90534695
146platelet dense granule organization (GO:0060155)2.87850822
147phosphatidylglycerol metabolic process (GO:0046471)2.86767867
148DNA double-strand break processing (GO:0000729)2.84251182
149transmission of nerve impulse (GO:0019226)2.82741753
150spinal cord motor neuron differentiation (GO:0021522)2.81407058
151reciprocal DNA recombination (GO:0035825)2.81165483
152reciprocal meiotic recombination (GO:0007131)2.81165483
153sulfation (GO:0051923)2.80355605
154tachykinin receptor signaling pathway (GO:0007217)2.78716805
155regulation of acrosome reaction (GO:0060046)2.76899707
156inner ear receptor stereocilium organization (GO:0060122)2.76780669
157preassembly of GPI anchor in ER membrane (GO:0016254)2.76299821
158glycosphingolipid biosynthetic process (GO:0006688)2.75689050
159protein-cofactor linkage (GO:0018065)2.71517063
160water-soluble vitamin biosynthetic process (GO:0042364)2.70416785
161replication fork processing (GO:0031297)2.70003434
162negative regulation of transcription regulatory region DNA binding (GO:2000678)2.69282677
163cyclic nucleotide catabolic process (GO:0009214)2.69114607
164eye photoreceptor cell development (GO:0042462)2.68175757
165C4-dicarboxylate transport (GO:0015740)2.67984779
166protein polyglutamylation (GO:0018095)2.67669222
167auditory receptor cell stereocilium organization (GO:0060088)2.67605405
168limb bud formation (GO:0060174)2.66982355
169regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.64870865
170regulation of action potential (GO:0098900)2.63243733
171DNA methylation involved in gamete generation (GO:0043046)2.63226134
172mitochondrial respiratory chain complex assembly (GO:0033108)2.62550765
173cellular biogenic amine catabolic process (GO:0042402)2.61255663
174amine catabolic process (GO:0009310)2.61255663
175mannosylation (GO:0097502)2.59945467
176regulation of hippo signaling (GO:0035330)2.59302578
177reflex (GO:0060004)2.58370805
178S-adenosylmethionine metabolic process (GO:0046500)2.55815654
179negative regulation of telomere maintenance (GO:0032205)2.55691758
180negative regulation of synaptic transmission, GABAergic (GO:0032229)2.54709901
181G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.54180053
182nonmotile primary cilium assembly (GO:0035058)2.52859607
183negative regulation of cytosolic calcium ion concentration (GO:0051481)2.52839986
184serotonin metabolic process (GO:0042428)2.52300021
185thyroid hormone metabolic process (GO:0042403)2.51648039
186neuron fate determination (GO:0048664)2.51570568
187nephron tubule morphogenesis (GO:0072078)2.51475313
188nephron epithelium morphogenesis (GO:0072088)2.51475313
189regulation of rhodopsin mediated signaling pathway (GO:0022400)2.51032122
190rhodopsin mediated signaling pathway (GO:0016056)2.50686395
191rRNA catabolic process (GO:0016075)2.50549912

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human4.35678814
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.46997369
3GBX2_23144817_ChIP-Seq_PC3_Human3.29942035
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.80231264
5IGF1R_20145208_ChIP-Seq_DFB_Human2.79647998
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.70777919
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.46557857
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.45435022
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42263253
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30747600
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.26717970
12EWS_26573619_Chip-Seq_HEK293_Human2.14921880
13TAF15_26573619_Chip-Seq_HEK293_Human2.13238782
14P300_19829295_ChIP-Seq_ESCs_Human2.12451506
15FUS_26573619_Chip-Seq_HEK293_Human2.12308840
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.08144907
17ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.07207964
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06672127
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.05319700
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.93799491
21PPAR_26484153_Chip-Seq_NCI-H1993_Human1.92930676
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.91653984
23FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.90462849
24ELK4_26923725_Chip-Seq_MESODERM_Mouse1.85777538
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82967462
26ER_23166858_ChIP-Seq_MCF-7_Human1.81743741
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.80237732
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76441401
29IRF1_19129219_ChIP-ChIP_H3396_Human1.74382538
30GATA1_26923725_Chip-Seq_HPCs_Mouse1.72290470
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.64802364
32AR_21572438_ChIP-Seq_LNCaP_Human1.64794687
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64524841
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63892387
35TP53_22573176_ChIP-Seq_HFKS_Human1.62645191
36GATA4_25053715_ChIP-Seq_YYC3_Human1.62297063
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60262979
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58352738
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.57864787
40SMAD4_21799915_ChIP-Seq_A2780_Human1.56319179
41RUNX1_27514584_Chip-Seq_MCF-7_Human1.54963487
42STAT3_23295773_ChIP-Seq_U87_Human1.54923081
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54801803
44* STAT1_20625510_ChIP-Seq_HELA_Human1.52475957
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.49842893
46NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48780009
47TCF4_23295773_ChIP-Seq_U87_Human1.45038394
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44896799
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44041569
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43863371
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.43208621
52DROSHA_22980978_ChIP-Seq_HELA_Human1.40608744
53* TCF4_22108803_ChIP-Seq_LS180_Human1.39505596
54* SOX2_19829295_ChIP-Seq_ESCs_Human1.38373498
55* NANOG_19829295_ChIP-Seq_ESCs_Human1.38373498
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.37801811
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.37407070
58VDR_22108803_ChIP-Seq_LS180_Human1.37111047
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36625914
60CDX2_20551321_ChIP-Seq_CACO-2_Human1.35849792
61ZNF274_21170338_ChIP-Seq_K562_Hela1.35593893
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.35276969
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34595289
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34361711
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.34205193
66SOX2_27498859_Chip-Seq_STOMACH_Mouse1.31176355
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31143303
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.30897988
69EZH2_22144423_ChIP-Seq_EOC_Human1.30843796
70TRIM28_21343339_ChIP-Seq_HEK293_Human1.30231077
71Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.28898305
72PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.28663219
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27788192
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26865023
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.26562625
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25638160
77FOXA1_25329375_ChIP-Seq_VCAP_Human1.24672184
78FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24672184
79STAT1_17558387_ChIP-Seq_HELA_Human1.24003013
80SMAD4_21741376_ChIP-Seq_EPCs_Human1.23864382
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23430151
82RUNX2_22187159_ChIP-Seq_PCA_Human1.23376860
83REST_21632747_ChIP-Seq_MESCs_Mouse1.22322356
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.22155020
85FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21279710
86RUNX1_26923725_Chip-Seq_HPCs_Mouse1.20860471
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20127614
88* MYC_18940864_ChIP-ChIP_HL60_Human1.19583274
89MYC_27129775_Chip-Seq_CORNEA_Mouse1.19152949
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18619294
91IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18606034
92GF1_26923725_Chip-Seq_HPCs_Mouse1.18445261
93GABP_17652178_ChIP-ChIP_JURKAT_Human1.18018795
94FLI1_21867929_ChIP-Seq_TH2_Mouse1.17243830
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16972534
96RNF2_27304074_Chip-Seq_NSC_Mouse1.16705989
97CRX_20693478_ChIP-Seq_RETINA_Mouse1.16067099
98PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.15725136
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15618954
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14974550
101CDX2_22108803_ChIP-Seq_LS180_Human1.12426056
102TP53_18474530_ChIP-ChIP_U2OS_Human1.12302960
103KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.12067398
104EST1_17652178_ChIP-ChIP_JURKAT_Human1.12037257
105NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10859426
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10684072
107NANOG_18555785_Chip-Seq_ESCs_Mouse1.10290289
108CJUN_26792858_Chip-Seq_BT549_Human1.09666849
109* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09544641
110PRDM14_20953172_ChIP-Seq_ESCs_Human1.09235285
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08860733
112EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08347134
113* GATA3_21878914_ChIP-Seq_MCF-7_Human1.08010862
114GF1B_26923725_Chip-Seq_HPCs_Mouse1.07984013
115SOX2_20726797_ChIP-Seq_SW620_Human1.07414955
116NCOR_22424771_ChIP-Seq_293T_Human1.07095862
117KLF5_25053715_ChIP-Seq_YYC3_Human1.06091146
118FOXO3_23340844_ChIP-Seq_DLD1_Human1.04421949
119AHR_22903824_ChIP-Seq_MCF-7_Human1.04321247
120AR_20517297_ChIP-Seq_VCAP_Human1.04206655
121ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03880442
122SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03292003
123TP53_16413492_ChIP-PET_HCT116_Human1.02779805
124CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02725698
125HOXB7_26014856_ChIP-Seq_BT474_Human1.02585482
126EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02237193
127P53_22387025_ChIP-Seq_ESCs_Mouse1.01849075
128CBP_20019798_ChIP-Seq_JUKART_Human1.00357706
129IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00357706
130CTCF_27219007_Chip-Seq_Bcells_Human0.99991823
131CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98714951
132RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98660116
133POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98470431
134CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98298841
135E2F1_18555785_Chip-Seq_ESCs_Mouse0.98028322
136STAT3_18555785_Chip-Seq_ESCs_Mouse0.97755558
137OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97540861
138NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96650158
139CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96579505
140SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96289371
141RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95970269
142SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95243751
143PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94560348
144TAL1_26923725_Chip-Seq_HPCs_Mouse0.94353124
145SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.93975450
146SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93651661
147AR_21909140_ChIP-Seq_LNCAP_Human0.93037103
148FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92275223
149FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.91865891
150ARNT_22903824_ChIP-Seq_MCF-7_Human0.91064832
151BCAT_22108803_ChIP-Seq_LS180_Human0.90153507
152EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89317573
153SMAD_19615063_ChIP-ChIP_OVARY_Human0.89156143
154TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88837189
155POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88837189
156TBL1_22424771_ChIP-Seq_293T_Human0.88495782
157EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87126369
158ERG_20517297_ChIP-Seq_VCAP_Human0.85012017
159GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.84885792
160KDM2B_26808549_Chip-Seq_REH_Human0.84884126
161* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84663861
162* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84620005
163TCF7_22412390_ChIP-Seq_EML_Mouse0.84149998
164PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83963557
165SMAD3_21741376_ChIP-Seq_ESCs_Human0.83843151
166GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.83711582
167TP63_22573176_ChIP-Seq_HFKS_Human0.83448901
168BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83431863
169SUZ12_27294783_Chip-Seq_ESCs_Mouse0.82462286
170IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.82390692
171GATA6_25053715_ChIP-Seq_YYC3_Human0.82240491
172RXR_22108803_ChIP-Seq_LS180_Human0.81970959
173JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81680662
174TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81198450
175KAP1_22055183_ChIP-Seq_ESCs_Mouse0.80946999
176RAD21_21589869_ChIP-Seq_MESCs_Mouse0.80934325
177RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80683434
178SMC4_20622854_ChIP-Seq_HELA_Human0.80317984
179VDR_24787735_ChIP-Seq_THP-1_Human0.79890165
180KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.79719717
181AR_25329375_ChIP-Seq_VCAP_Human0.79385452
182CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.78639413

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity9.97557489
2MP0008004_abnormal_stomach_pH4.55551861
3MP0005410_abnormal_fertilization4.47546717
4MP0003195_calcinosis3.84947536
5MP0002148_abnormal_hypersensitivity_rea3.80390006
6MP0002254_reproductive_system_inflammat3.51520970
7MP0000490_abnormal_crypts_of3.32635797
8MP0002102_abnormal_ear_morphology2.99904204
9MP0005377_hearing/vestibular/ear_phenot2.88206685
10MP0003878_abnormal_ear_physiology2.88206685
11MP0005645_abnormal_hypothalamus_physiol2.86636949
12MP0000569_abnormal_digit_pigmentation2.85890404
13MP0005360_urolithiasis2.74535725
14MP0002653_abnormal_ependyma_morphology2.73522800
15MP0003718_maternal_effect2.69606238
16MP0005551_abnormal_eye_electrophysiolog2.69112866
17MP0010155_abnormal_intestine_physiology2.57241861
18MP0001873_stomach_inflammation2.48709629
19MP0000372_irregular_coat_pigmentation2.35747802
20MP0004264_abnormal_extraembryonic_tissu2.34734573
21MP0006276_abnormal_autonomic_nervous2.26856118
22MP0001666_abnormal_nutrient_absorption2.25653771
23MP0008875_abnormal_xenobiotic_pharmacok2.23680798
24MP0009046_muscle_twitch2.07230094
25MP0003880_abnormal_central_pattern2.05414699
26MP0003879_abnormal_hair_cell1.92788445
27MP0003183_abnormal_peptide_metabolism1.87641705
28MP0003136_yellow_coat_color1.82938121
29MP0005253_abnormal_eye_physiology1.80920831
30MP0004858_abnormal_nervous_system1.76947583
31MP0008872_abnormal_physiological_respon1.76524798
32MP0005395_other_phenotype1.74356534
33MP0009745_abnormal_behavioral_response1.72549178
34MP0001346_abnormal_lacrimal_gland1.71376059
35MP0005023_abnormal_wound_healing1.69803720
36MP0000427_abnormal_hair_cycle1.65298922
37MP0000538_abnormal_urinary_bladder1.64949255
38MP0006072_abnormal_retinal_apoptosis1.63561530
39MP0000477_abnormal_intestine_morphology1.62955770
40MP0008877_abnormal_DNA_methylation1.62566913
41MP0001501_abnormal_sleep_pattern1.57907264
42MP0000383_abnormal_hair_follicle1.55692005
43MP0000631_abnormal_neuroendocrine_gland1.55461318
44MP0004142_abnormal_muscle_tone1.54009762
45MP0004043_abnormal_pH_regulation1.50331579
46MP0002736_abnormal_nociception_after1.49939743
47MP0002272_abnormal_nervous_system1.49679075
48MP0004742_abnormal_vestibular_system1.49080671
49MP0001929_abnormal_gametogenesis1.48104327
50MP0002735_abnormal_chemical_nociception1.47491639
51MP0003698_abnormal_male_reproductive1.44890843
52MP0009780_abnormal_chondrocyte_physiolo1.44687371
53MP0005646_abnormal_pituitary_gland1.40731236
54MP0001348_abnormal_lacrimal_gland1.38906709
55MP0001486_abnormal_startle_reflex1.36446730
56MP0002638_abnormal_pupillary_reflex1.36015166
57MP0003868_abnormal_feces_composition1.33780831
58MP0009384_cardiac_valve_regurgitation1.33184469
59MP0003436_decreased_susceptibility_to1.31075014
60MP0002163_abnormal_gland_morphology1.30465434
61MP0004924_abnormal_behavior1.30463940
62MP0005386_behavior/neurological_phenoty1.30463940
63MP0005174_abnormal_tail_pigmentation1.29219927
64MP0003300_gastrointestinal_ulcer1.28605793
65MP0001664_abnormal_digestion1.27799593
66MP0002938_white_spotting1.27655271
67MP0002837_dystrophic_cardiac_calcinosis1.27012786
68MP0001529_abnormal_vocalization1.25920671
69MP0004147_increased_porphyrin_level1.25626630
70MP0003866_abnormal_defecation1.24008262
71MP0002572_abnormal_emotion/affect_behav1.23585432
72MP0005379_endocrine/exocrine_gland_phen1.21558711
73MP0002405_respiratory_system_inflammati1.19937834
74MP0009840_abnormal_foam_cell1.18808383
75MP0003646_muscle_fatigue1.18280741
76MP0003252_abnormal_bile_duct1.17822833
77MP0001970_abnormal_pain_threshold1.17041568
78MP0001663_abnormal_digestive_system1.16683795
79MP0003121_genomic_imprinting1.15561584
80MP0005389_reproductive_system_phenotype1.15129155
81MP0005423_abnormal_somatic_nervous1.14684166
82MP0001984_abnormal_olfaction1.13742600
83MP0001764_abnormal_homeostasis1.13000097
84MP0000462_abnormal_digestive_system1.12644710
85MP0004133_heterotaxia1.12381720
86MP0003075_altered_response_to1.12365212
87MP0002909_abnormal_adrenal_gland1.11586660
88MP0005171_absent_coat_pigmentation1.11054662
89MP0002168_other_aberrant_phenotype1.10884480
90MP0002277_abnormal_respiratory_mucosa1.09922672
91MP0005084_abnormal_gallbladder_morpholo1.08882975
92MP0002064_seizures1.08654339
93MP0002557_abnormal_social/conspecific_i1.07133586
94MP0008995_early_reproductive_senescence1.06766351
95MP0003011_delayed_dark_adaptation1.06559484
96MP0000026_abnormal_inner_ear1.06521152
97MP0001849_ear_inflammation1.05629237
98MP0002234_abnormal_pharynx_morphology1.04316857
99MP0008058_abnormal_DNA_repair1.03006424
100MP0002067_abnormal_sensory_capabilities1.02993797
101MP0005666_abnormal_adipose_tissue1.02754110
102MP0002733_abnormal_thermal_nociception1.02035261
103MP0006292_abnormal_olfactory_placode1.01776959
104MP0005310_abnormal_salivary_gland1.00594960
105MP0002229_neurodegeneration1.00448191
106MP0002876_abnormal_thyroid_physiology1.00005903
107MP0010386_abnormal_urinary_bladder0.99554287
108MP0010352_gastrointestinal_tract_polyps0.98194360
109MP0005195_abnormal_posterior_eye0.96582068
110MP0003635_abnormal_synaptic_transmissio0.96187832
111MP0002249_abnormal_larynx_morphology0.95661968
112MP0001919_abnormal_reproductive_system0.95645572
113MP0005381_digestive/alimentary_phenotyp0.95478375
114MP0005000_abnormal_immune_tolerance0.95325613
115MP0005085_abnormal_gallbladder_physiolo0.94146551
116MP0002752_abnormal_somatic_nervous0.93370382
117MP0004145_abnormal_muscle_electrophysio0.92544836
118MP0010234_abnormal_vibrissa_follicle0.91073876
119MP0005464_abnormal_platelet_physiology0.91049525
120MP0003787_abnormal_imprinting0.91021051
121MP0002095_abnormal_skin_pigmentation0.90644923
122MP0008057_abnormal_DNA_replication0.90444045
123MP0002751_abnormal_autonomic_nervous0.88871631
124MP0002138_abnormal_hepatobiliary_system0.88682414
125MP0002063_abnormal_learning/memory/cond0.88037163
126MP0001905_abnormal_dopamine_level0.87650725
127MP0000647_abnormal_sebaceous_gland0.86483645
128MP0002295_abnormal_pulmonary_circulatio0.86097412
129MP0005365_abnormal_bile_salt0.85621285
130MP0003638_abnormal_response/metabolism_0.84167920
131MP0010678_abnormal_skin_adnexa0.83853170
132MP0000230_abnormal_systemic_arterial0.83020712
133MP0001324_abnormal_eye_pigmentation0.83006707
134MP0000049_abnormal_middle_ear0.79959438
135MP0000778_abnormal_nervous_system0.79838385
136MP0001533_abnormal_skeleton_physiology0.79779588
137MP0001968_abnormal_touch/_nociception0.79112122
138MP0001845_abnormal_inflammatory_respons0.79074742
139MP0002161_abnormal_fertility/fecundity0.77854605
140MP0000685_abnormal_immune_system0.75096386
141MP0003303_peritoneal_inflammation0.72325468
142MP0005387_immune_system_phenotype0.72161817
143MP0001790_abnormal_immune_system0.72161817
144MP0003045_fibrosis0.71854858
145MP0003091_abnormal_cell_migration0.71731551
146MP0002282_abnormal_trachea_morphology0.70265977
147MP0000465_gastrointestinal_hemorrhage0.69689335
148MP0002928_abnormal_bile_duct0.69382276
149MP0004885_abnormal_endolymph0.68340825
150MP0001216_abnormal_epidermal_layer0.67937229
151MP0006138_congestive_heart_failure0.66634319
152MP0000653_abnormal_sex_gland0.64791440
153MP0002160_abnormal_reproductive_system0.64784573
154MP0002210_abnormal_sex_determination0.64076420
155MP0000579_abnormal_nail_morphology0.60959927
156MP0006082_CNS_inflammation0.60872209
157MP0005670_abnormal_white_adipose0.60690039
158MP0005166_decreased_susceptibility_to0.60600412
159MP0010329_abnormal_lipoprotein_level0.59960054
160MP0004019_abnormal_vitamin_homeostasis0.58699103
161MP0001765_abnormal_ion_homeostasis0.56669012
162MP0003453_abnormal_keratinocyte_physiol0.56457990
163MP0000534_abnormal_ureter_morphology0.55712686
164MP0001485_abnormal_pinna_reflex0.55578933
165MP0005165_increased_susceptibility_to0.54569597
166MP0005390_skeleton_phenotype0.53857791
167MP0005076_abnormal_cell_differentiation0.52668832
168MP0009278_abnormal_bone_marrow0.52486766
169MP0000470_abnormal_stomach_morphology0.52108440
170MP0003172_abnormal_lysosome_physiology0.51976009
171MP0001145_abnormal_male_reproductive0.49925485
172MP0003279_aneurysm0.48631733
173MP0001800_abnormal_humoral_immune0.48188113
174MP0001545_abnormal_hematopoietic_system0.46583098
175MP0005397_hematopoietic_system_phenotyp0.46583098
176MP0003950_abnormal_plasma_membrane0.45303595
177MP0003566_abnormal_cell_adhesion0.45209677

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.88165441
2Right ventricular cardiomyopathy (HP:0011663)5.69455666
3Absent/shortened dynein arms (HP:0200106)5.31522392
4Dynein arm defect of respiratory motile cilia (HP:0012255)5.31522392
5Abnormal respiratory motile cilium physiology (HP:0012261)4.84212623
6Pancreatic cysts (HP:0001737)4.17084173
7Abnormal respiratory motile cilium morphology (HP:0005938)4.09232377
8Abnormal respiratory epithelium morphology (HP:0012253)4.09232377
9Chronic sinusitis (HP:0011109)4.07152254
10Rhinitis (HP:0012384)4.07094595
11Bundle branch block (HP:0011710)4.07010790
12Neonatal short-limb short stature (HP:0008921)4.01106240
13Micronodular cirrhosis (HP:0001413)3.89990966
14True hermaphroditism (HP:0010459)3.86700353
15Abnormal ciliary motility (HP:0012262)3.83026028
16Abnormal sex determination (HP:0012244)3.78686229
17Sex reversal (HP:0012245)3.78686229
18Pancreatic fibrosis (HP:0100732)3.77832430
19Chronic bronchitis (HP:0004469)3.74675476
20Congenital stationary night blindness (HP:0007642)3.63900591
21Nasal polyposis (HP:0100582)3.62744206
22Molar tooth sign on MRI (HP:0002419)3.61679210
23Abnormality of midbrain morphology (HP:0002418)3.61679210
24Aplasia of the phalanges of the hand (HP:0009802)3.51112085
25Aplasia involving bones of the extremities (HP:0009825)3.51112085
26Aplasia involving bones of the upper limbs (HP:0009823)3.51112085
27Attenuation of retinal blood vessels (HP:0007843)3.49085421
28Hyperventilation (HP:0002883)3.46168886
29Gait imbalance (HP:0002141)3.32810271
30Congenital primary aphakia (HP:0007707)3.31903921
31Nephronophthisis (HP:0000090)3.25538281
32Heart block (HP:0012722)3.25490887
33Abnormal atrioventricular conduction (HP:0005150)3.22143760
34Aplasia/Hypoplasia of the sternum (HP:0006714)3.14318207
35Infertility (HP:0000789)3.06236786
36Bronchitis (HP:0012387)3.05659744
3711 pairs of ribs (HP:0000878)3.03704466
38Vascular calcification (HP:0004934)3.02177474
39Esophageal varix (HP:0002040)3.01412664
40Medial flaring of the eyebrow (HP:0010747)3.01239620
41Abnormality of the renal cortex (HP:0011035)3.00957759
42Abnormality of the renal medulla (HP:0100957)2.92624812
43Type II lissencephaly (HP:0007260)2.92579238
44Abnormal rod and cone electroretinograms (HP:0008323)2.91539535
45Abnormality of the nasal mucosa (HP:0000433)2.90704464
46Cardiovascular calcification (HP:0011915)2.78346508
47Abolished electroretinogram (ERG) (HP:0000550)2.78146187
48Poor coordination (HP:0002370)2.77700458
49Nephrogenic diabetes insipidus (HP:0009806)2.77659091
50Bony spicule pigmentary retinopathy (HP:0007737)2.76603780
51Absent rod-and cone-mediated responses on ERG (HP:0007688)2.73778388
52Hypothermia (HP:0002045)2.68492597
53Constricted visual fields (HP:0001133)2.68474944
54Male infertility (HP:0003251)2.68431412
55Hypoplasia of dental enamel (HP:0006297)2.67932676
56Recurrent bronchitis (HP:0002837)2.59649257
57Milia (HP:0001056)2.59246725
58Fatigable weakness (HP:0003473)2.58125246
59Abnormality of the neuromuscular junction (HP:0003398)2.58125246
60Supernumerary spleens (HP:0009799)2.58104866
61Decreased circulating renin level (HP:0003351)2.57167009
62Abdominal distention (HP:0003270)2.55471972
63Vaginal atresia (HP:0000148)2.55127536
64Genital tract atresia (HP:0001827)2.54809571
65Absent speech (HP:0001344)2.53858751
66Cystic liver disease (HP:0006706)2.50581889
67Gaze-evoked nystagmus (HP:0000640)2.49303830
68Decreased central vision (HP:0007663)2.48667571
69Bronchomalacia (HP:0002780)2.48400232
70Acute necrotizing encephalopathy (HP:0006965)2.46341697
71Interstitial pulmonary disease (HP:0006530)2.42860567
72Abnormal vertebral ossification (HP:0100569)2.42299783
73Increased CSF lactate (HP:0002490)2.41457941
74Lissencephaly (HP:0001339)2.40996546
75Large for gestational age (HP:0001520)2.39994660
76Pendular nystagmus (HP:0012043)2.38277263
77Tibial bowing (HP:0002982)2.37262294
78Mitochondrial inheritance (HP:0001427)2.35546436
79Abnormal biliary tract physiology (HP:0012439)2.35266770
80Bile duct proliferation (HP:0001408)2.35266770
81Tubular atrophy (HP:0000092)2.33721825
82Inability to walk (HP:0002540)2.33543513
83Renal cortical cysts (HP:0000803)2.33402534
84Bronchiectasis (HP:0002110)2.32172103
85Distal lower limb muscle weakness (HP:0009053)2.30679701
86Hypoplastic scapulae (HP:0000882)2.29087989
87Aplasia/Hypoplasia of the scapulae (HP:0006713)2.29087989
88Cerebellar dysplasia (HP:0007033)2.28598397
89Asplenia (HP:0001746)2.28000026
90Intestinal atresia (HP:0011100)2.26604809
91Aplasia/Hypoplasia of the spleen (HP:0010451)2.26183992
92Acute encephalopathy (HP:0006846)2.24490082
93Progressive macrocephaly (HP:0004481)2.22819835
94Broad-based gait (HP:0002136)2.22101586
95Optic disc pallor (HP:0000543)2.21505182
96Respiratory distress (HP:0002098)2.19923581
97Congenital sensorineural hearing impairment (HP:0008527)2.19467804
98Polydipsia (HP:0001959)2.16328980
99Abnormal drinking behavior (HP:0030082)2.16328980
1003-Methylglutaconic aciduria (HP:0003535)2.15968592
101Autoimmune thrombocytopenia (HP:0001973)2.15542105
102Febrile seizures (HP:0002373)2.14555996
103Epiphyseal dysplasia (HP:0002656)2.13684281
104Progressive inability to walk (HP:0002505)2.13430064
105Tetraparesis (HP:0002273)2.12546360
106Abnormality of liposaccharide metabolism (HP:0010968)2.12542400
107Abnormality of glycosphingolipid metabolism (HP:0004343)2.12542400
108Abnormality of glycolipid metabolism (HP:0010969)2.12542400
109Increased corneal curvature (HP:0100692)2.11645134
110Keratoconus (HP:0000563)2.11645134
111Widely spaced teeth (HP:0000687)2.11469724
112Mixed hearing impairment (HP:0000410)2.11299723
113Hyperglycinuria (HP:0003108)2.10658214
114Lip pit (HP:0100267)2.10515396
115Cone-rod dystrophy (HP:0000548)2.10311595
116Selective tooth agenesis (HP:0001592)2.09672892
117Abnormality of the pons (HP:0007361)2.09163047
118Aplasia/Hypoplasia of the tongue (HP:0010295)2.08683630
119Decreased electroretinogram (ERG) amplitude (HP:0000654)2.08154862
120Sclerocornea (HP:0000647)2.04926361
121Male pseudohermaphroditism (HP:0000037)2.03144361
122Chronic hepatic failure (HP:0100626)2.02995633
123Fibular hypoplasia (HP:0003038)2.02657601
124Recurrent gram-negative bacterial infections (HP:0005420)2.02052005
125Lipid accumulation in hepatocytes (HP:0006561)2.01811002
126Congenital hepatic fibrosis (HP:0002612)2.00747597
127Aplasia/Hypoplasia of the lens (HP:0008063)1.99858606
128Polyuria (HP:0000103)1.98720145
129Short palpebral fissure (HP:0012745)1.98469029
130Decreased muscle mass (HP:0003199)1.97422542
131Abnormal mitochondria in muscle tissue (HP:0008316)1.96265121
132Aplasia/Hypoplasia of the tibia (HP:0005772)1.96068337
133Volvulus (HP:0002580)1.94745743
134Ventricular arrhythmia (HP:0004308)1.93886226
135Atrophic scars (HP:0001075)1.93399220
136Ketoacidosis (HP:0001993)1.93382897
137Ventricular tachycardia (HP:0004756)1.93339928
138Abnormality of alanine metabolism (HP:0010916)1.92276149
139Hyperalaninemia (HP:0003348)1.92276149
140Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92276149
141Hypoplasia of the pons (HP:0012110)1.92247548
142Focal motor seizures (HP:0011153)1.91656346
143Impulsivity (HP:0100710)1.90336558
144Upper limb muscle weakness (HP:0003484)1.89506803
145Fair hair (HP:0002286)1.88985387
146Pachygyria (HP:0001302)1.88417274
147Postaxial foot polydactyly (HP:0001830)1.88101234
148Anencephaly (HP:0002323)1.87523656
149Increased hepatocellular lipid droplets (HP:0006565)1.86629024
150Aplasia/Hypoplasia of the uvula (HP:0010293)1.85241525
151Stomatitis (HP:0010280)1.84811697
152Broad foot (HP:0001769)1.83402072
153Hypercortisolism (HP:0001578)1.82991370
154Ulnar claw (HP:0001178)1.82768129
155Retinitis pigmentosa (HP:0000510)1.82552294
156Abnormal glucose tolerance (HP:0001952)1.81701537
157Prolonged QT interval (HP:0001657)1.81461516
158Small hand (HP:0200055)1.81036523
159Furrowed tongue (HP:0000221)1.80777675
160Astigmatism (HP:0000483)1.79685113
161Concave nail (HP:0001598)1.78968947
162Natal tooth (HP:0000695)1.78767112
163Abnormality of the gastric mucosa (HP:0004295)1.78733038
164Hypoplastic ischia (HP:0003175)1.78700456
165Clumsiness (HP:0002312)1.78345243
166Hypomagnesemia (HP:0002917)1.77657510
167Sprengel anomaly (HP:0000912)1.77001459
168Chronic diarrhea (HP:0002028)1.76513079
169Hypokalemic alkalosis (HP:0001949)1.74983703
170Bradycardia (HP:0001662)1.74662474
171Syncope (HP:0001279)1.74063472
172Chronic otitis media (HP:0000389)1.72248871
173Cerebral edema (HP:0002181)1.72135306
174Ketosis (HP:0001946)1.72090839
175Severe muscular hypotonia (HP:0006829)1.72076218
176Hepatocellular necrosis (HP:0001404)1.71523213
177Hepatic necrosis (HP:0002605)1.71480251
178Optic nerve hypoplasia (HP:0000609)1.71376786
179Retinal dysplasia (HP:0007973)1.71217692
180Protruding tongue (HP:0010808)1.71020514
181Abnormality of permanent molar morphology (HP:0011071)1.70710135
182Abnormality of the dental root (HP:0006486)1.70710135
183Taurodontia (HP:0000679)1.70710135
184Hypodontia (HP:0000668)1.69366643
185Curly hair (HP:0002212)1.69054840
186Abnormal gallbladder physiology (HP:0012438)1.68054585
187Cholecystitis (HP:0001082)1.68054585
188Breech presentation (HP:0001623)1.67086769
189Fragile nails (HP:0001808)1.66665208
190Protuberant abdomen (HP:0001538)1.64228630

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK55.53158145
2NME15.01730933
3ERBB34.97891552
4KSR23.41456925
5WNK33.32055091
6TRPM73.31837670
7MAP4K22.95170878
8MKNK12.94440120
9ADRBK22.89534234
10RPS6KB22.80794535
11INSRR2.69384326
12FRK2.64372465
13DMPK2.64134046
14RAF12.52502612
15CASK2.42112860
16MARK12.40993462
17PINK12.36219307
18GRK12.08635226
19TEC2.07265655
20ZAK2.01018312
21BMPR21.85639940
22WNK41.85074602
23MAPK131.82692253
24KSR11.82507774
25PNCK1.81307380
26PDK31.77350143
27PDK41.77350143
28TESK11.75549925
29TNIK1.71986203
30PAK61.67579573
31BMPR1B1.62678591
32ACVR1B1.61351222
33TXK1.58758329
34TAOK31.53111630
35CDK31.49143652
36TRIM281.44376143
37PAK31.44271399
38LATS11.43959595
39TLK11.43157575
40EEF2K1.42912544
41STK391.41125480
42TAF11.37984181
43EPHA41.37927436
44PRKD31.36430714
45MAP3K41.36393284
46ERN11.35615646
47ICK1.35054739
48BRSK21.28655683
49TAOK11.28158197
50OXSR11.25807225
51MKNK21.25573544
52PDK21.25450328
53MAP2K11.21792385
54DDR21.20792839
55MUSK1.16172298
56RPS6KA51.15790458
57WEE11.15286599
58PTK21.13352542
59IRAK21.11043598
60RIPK41.10890076
61BTK1.09863131
62MAPKAPK21.09487997
63MAPK151.05826848
64ADRBK11.00011580
65VRK10.98391045
66DYRK20.98210822
67ITK0.96971889
68VRK20.94494422
69CAMKK20.94383144
70HCK0.90999297
71PIK3CG0.90263556
72PRKCG0.90208085
73TBK10.89931226
74EIF2AK30.87532431
75CDK60.86098912
76STK38L0.84549248
77MAP3K20.84411251
78TYK20.84324708
79STK30.81821442
80MAP2K70.77987476
81TSSK60.76963038
82MAP2K20.74197140
83PLK20.73519230
84PTK60.73132701
85CCNB10.72673220
86NTRK30.72401702
87EPHA20.71755888
88PRKCQ0.71710815
89CSNK1G10.71523678
90BCKDK0.70721260
91MAPKAPK30.69949079
92MST40.69096224
93CSNK1G30.68861441
94CDK120.68178546
95MAPK70.67476375
96FGFR20.66876209
97CSNK1G20.65942572
98CAMK2A0.64855817
99CSF1R0.63138230
100IKBKE0.61855018
101CDK90.60802896
102DAPK20.60175538
103DYRK1B0.58288695
104SIK20.57707052
105NUAK10.56966200
106BLK0.55486249
107STK240.55125513
108LMTK20.54080303
109PLK30.54030949
110NTRK20.53762577
111RPS6KA20.52734378
112IKBKB0.52645889
113CHUK0.51457036
114PKN10.51206565
115CAMK2G0.49609862
116BCR0.48557791
117AKT30.48316543
118PHKG10.48007910
119PHKG20.48007910
120CAMK1G0.47797633
121PRKAA20.46654145
122PRKACA0.46168964
123IRAK10.45070706
124CAMK2D0.44813731
125NEK60.44777192
126TGFBR10.43566202
127PRKG10.42077348
128PRKCI0.40942067
129PDPK10.40923329
130MAP2K60.40509968
131PTK2B0.40121144
132CSNK1D0.39703574
133GRK50.39478651
134PRKAA10.39172793
135LATS20.38838599
136PRKCZ0.38264938
137CSNK1A10.37959235
138KIT0.37730551
139CAMK10.37267466
140STK110.36993986
141FER0.36779563
142TIE10.35529639
143CAMK2B0.35304966
144PDK10.34904309
145PRKCA0.33945582
146FGR0.33303088
147MAP3K10.31456006
148ERBB20.31050063
149PRKCE0.30730648
150MAP3K140.30553254
151CHEK20.30467036
152PRKCD0.29423208
153STK100.29377204
154RPS6KA10.29187426
155MET0.28280619
156EGFR0.27277855
157MAP3K90.27025518
158CSNK1A1L0.26305421
159CDC42BPA0.24911027
160ARAF0.24695895
161MAPK40.23848166
162MAP3K70.23814668
163PIM20.23651387
164STK380.23531048
165MATK0.23238811
166JAK20.23050180
167CSK0.21832505
168IGF1R0.20835363
169PAK10.20564412
170ROCK10.17393819

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.60635255
2Linoleic acid metabolism_Homo sapiens_hsa005914.47828402
3Carbohydrate digestion and absorption_Homo sapiens_hsa049733.68971390
4Arachidonic acid metabolism_Homo sapiens_hsa005903.51297729
5Fat digestion and absorption_Homo sapiens_hsa049752.91520535
6Ether lipid metabolism_Homo sapiens_hsa005652.90572060
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.75315655
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.72207948
9Phototransduction_Homo sapiens_hsa047442.65003614
10Butanoate metabolism_Homo sapiens_hsa006502.64874945
11Taste transduction_Homo sapiens_hsa047422.40648242
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.32692396
13Glycerophospholipid metabolism_Homo sapiens_hsa005642.28829530
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.28801203
15Glycerolipid metabolism_Homo sapiens_hsa005612.18613877
16Choline metabolism in cancer_Homo sapiens_hsa052312.18060220
17Maturity onset diabetes of the young_Homo sapiens_hsa049502.14639621
18Dorso-ventral axis formation_Homo sapiens_hsa043202.12765552
19Nitrogen metabolism_Homo sapiens_hsa009102.00156080
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.96461184
21Selenocompound metabolism_Homo sapiens_hsa004501.96162968
22Tryptophan metabolism_Homo sapiens_hsa003801.91907476
23Oxidative phosphorylation_Homo sapiens_hsa001901.90364910
24Protein export_Homo sapiens_hsa030601.83400185
25Basal transcription factors_Homo sapiens_hsa030221.82058697
26Nicotine addiction_Homo sapiens_hsa050331.81133868
27Homologous recombination_Homo sapiens_hsa034401.76533145
28Propanoate metabolism_Homo sapiens_hsa006401.69247248
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.67065278
30Fanconi anemia pathway_Homo sapiens_hsa034601.66230021
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.65760339
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.59089926
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.55434805
34Mineral absorption_Homo sapiens_hsa049781.55160363
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.52542520
36Parkinsons disease_Homo sapiens_hsa050121.51089655
37One carbon pool by folate_Homo sapiens_hsa006701.47328754
38Renin-angiotensin system_Homo sapiens_hsa046141.46531673
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44152111
40Olfactory transduction_Homo sapiens_hsa047401.43315417
41Phospholipase D signaling pathway_Homo sapiens_hsa040721.42431579
42Toxoplasmosis_Homo sapiens_hsa051451.38660482
43RNA polymerase_Homo sapiens_hsa030201.37813550
44PPAR signaling pathway_Homo sapiens_hsa033201.34137433
45VEGF signaling pathway_Homo sapiens_hsa043701.30884422
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.30294773
47Ovarian steroidogenesis_Homo sapiens_hsa049131.30204308
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.27138209
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27060341
50ABC transporters_Homo sapiens_hsa020101.26372284
51Sphingolipid metabolism_Homo sapiens_hsa006001.25949492
52Chemical carcinogenesis_Homo sapiens_hsa052041.23870601
53Morphine addiction_Homo sapiens_hsa050321.21561363
54B cell receptor signaling pathway_Homo sapiens_hsa046621.17291473
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16262307
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13861665
57Vitamin B6 metabolism_Homo sapiens_hsa007501.12428472
58Long-term depression_Homo sapiens_hsa047301.11277772
59Peroxisome_Homo sapiens_hsa041461.08582001
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06926284
61Retinol metabolism_Homo sapiens_hsa008301.06492095
62Vitamin digestion and absorption_Homo sapiens_hsa049771.02650396
63Huntingtons disease_Homo sapiens_hsa050160.99784880
64Serotonergic synapse_Homo sapiens_hsa047260.98347165
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97056752
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97008794
67GnRH signaling pathway_Homo sapiens_hsa049120.96027719
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95375962
69beta-Alanine metabolism_Homo sapiens_hsa004100.94645174
70RNA degradation_Homo sapiens_hsa030180.94275573
71Collecting duct acid secretion_Homo sapiens_hsa049660.90191024
72Leishmaniasis_Homo sapiens_hsa051400.89830682
73Pancreatic secretion_Homo sapiens_hsa049720.89448941
74Bile secretion_Homo sapiens_hsa049760.89236565
75Fructose and mannose metabolism_Homo sapiens_hsa000510.89120887
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.88566681
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.86233624
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85229763
79Regulation of autophagy_Homo sapiens_hsa041400.83792484
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83493346
81Non-homologous end-joining_Homo sapiens_hsa034500.81180668
82Inositol phosphate metabolism_Homo sapiens_hsa005620.80954062
83Glutamatergic synapse_Homo sapiens_hsa047240.79422004
84Proteasome_Homo sapiens_hsa030500.79023571
85Alzheimers disease_Homo sapiens_hsa050100.76490139
86GABAergic synapse_Homo sapiens_hsa047270.74883188
87Influenza A_Homo sapiens_hsa051640.74253061
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.73310851
89Tight junction_Homo sapiens_hsa045300.72419109
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72397934
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70974574
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68666519
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68244498
94Cardiac muscle contraction_Homo sapiens_hsa042600.67779240
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.67647002
96Circadian entrainment_Homo sapiens_hsa047130.67451340
97Protein digestion and absorption_Homo sapiens_hsa049740.66903769
98Calcium signaling pathway_Homo sapiens_hsa040200.66786884
99Pancreatic cancer_Homo sapiens_hsa052120.66271119
100Metabolic pathways_Homo sapiens_hsa011000.66221395
101Platelet activation_Homo sapiens_hsa046110.65556047
102Purine metabolism_Homo sapiens_hsa002300.64299359
103Fatty acid degradation_Homo sapiens_hsa000710.63114990
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62409146
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.60340529
106Amoebiasis_Homo sapiens_hsa051460.60029390
107Other glycan degradation_Homo sapiens_hsa005110.58473016
108Dopaminergic synapse_Homo sapiens_hsa047280.58022776
109Type II diabetes mellitus_Homo sapiens_hsa049300.58019589
110Estrogen signaling pathway_Homo sapiens_hsa049150.56919487
111Insulin resistance_Homo sapiens_hsa049310.56356151
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56334259
113Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55100046
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.54206149
115MAPK signaling pathway_Homo sapiens_hsa040100.53847558
116Hepatitis C_Homo sapiens_hsa051600.52638162
117Salivary secretion_Homo sapiens_hsa049700.52551377
118Osteoclast differentiation_Homo sapiens_hsa043800.52398334
119Fatty acid metabolism_Homo sapiens_hsa012120.51912455
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51285660
121Cyanoamino acid metabolism_Homo sapiens_hsa004600.51212833
122Sulfur metabolism_Homo sapiens_hsa009200.51048193
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49985813
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49901637
125TNF signaling pathway_Homo sapiens_hsa046680.49307631
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48351605
127Chronic myeloid leukemia_Homo sapiens_hsa052200.48113655
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47986461
129Gastric acid secretion_Homo sapiens_hsa049710.45417774
130Small cell lung cancer_Homo sapiens_hsa052220.45339935
131Acute myeloid leukemia_Homo sapiens_hsa052210.44455326
132Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42917649
133Bladder cancer_Homo sapiens_hsa052190.42850793
134cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42316679
135Steroid biosynthesis_Homo sapiens_hsa001000.42238993
136Glucagon signaling pathway_Homo sapiens_hsa049220.42111628
137Pyrimidine metabolism_Homo sapiens_hsa002400.41933854
138Ras signaling pathway_Homo sapiens_hsa040140.40107319
139Adherens junction_Homo sapiens_hsa045200.38463546
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38084208
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37761139
142Malaria_Homo sapiens_hsa051440.37374595
143Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36527195
144Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36200789
145Herpes simplex infection_Homo sapiens_hsa051680.36167001
146African trypanosomiasis_Homo sapiens_hsa051430.35963171
147Cocaine addiction_Homo sapiens_hsa050300.35656995
148Hepatitis B_Homo sapiens_hsa051610.35188146
149Prolactin signaling pathway_Homo sapiens_hsa049170.34906512
150Circadian rhythm_Homo sapiens_hsa047100.34539572
151Renal cell carcinoma_Homo sapiens_hsa052110.34287422
152Endometrial cancer_Homo sapiens_hsa052130.33695090
153Gap junction_Homo sapiens_hsa045400.32828905
154cAMP signaling pathway_Homo sapiens_hsa040240.32521101
155Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.32352785
156Pyruvate metabolism_Homo sapiens_hsa006200.32073830
157Histidine metabolism_Homo sapiens_hsa003400.31961934
158SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31728964
159Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31458274
160Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31356976
161Tuberculosis_Homo sapiens_hsa051520.31080903
162Insulin secretion_Homo sapiens_hsa049110.30286686
163Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29852567
164Lysine degradation_Homo sapiens_hsa003100.29098108
165Amphetamine addiction_Homo sapiens_hsa050310.28612382
166Proteoglycans in cancer_Homo sapiens_hsa052050.28551465
167Glutathione metabolism_Homo sapiens_hsa004800.28052998
168Caffeine metabolism_Homo sapiens_hsa002320.27599607
169Sulfur relay system_Homo sapiens_hsa041220.27152700
170Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26979457
171Toll-like receptor signaling pathway_Homo sapiens_hsa046200.26872577

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