SH2D7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1production of molecular mediator involved in inflammatory response (GO:0002532)9.07861413
2inflammatory response to antigenic stimulus (GO:0002437)9.02585874
3granulocyte differentiation (GO:0030851)7.57884802
4otic vesicle formation (GO:0030916)6.98416960
5detection of chemical stimulus involved in sensory perception of taste (GO:0050912)6.73574570
6sensory perception of taste (GO:0050909)6.58162187
7hepatocyte apoptotic process (GO:0097284)6.42542239
8detection of chemical stimulus involved in sensory perception (GO:0050907)5.84889882
9eye photoreceptor cell differentiation (GO:0001754)5.84364738
10photoreceptor cell differentiation (GO:0046530)5.84364738
11positive regulation of vesicle fusion (GO:0031340)5.72708150
12arachidonic acid secretion (GO:0050482)5.68313184
13icosanoid secretion (GO:0032309)5.68313184
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.50733846
15phosphatidylinositol acyl-chain remodeling (GO:0036149)5.35192583
16lipoxygenase pathway (GO:0019372)5.34164112
17response to fungus (GO:0009620)5.30997590
18establishment of protein localization to mitochondrial membrane (GO:0090151)5.10088028
19water-soluble vitamin biosynthetic process (GO:0042364)5.00419864
20maintenance of gastrointestinal epithelium (GO:0030277)4.96309315
21DNA replication checkpoint (GO:0000076)4.94927992
22phosphatidylserine acyl-chain remodeling (GO:0036150)4.84736338
23phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.72996515
24fatty acid derivative transport (GO:1901571)4.71901781
25icosanoid transport (GO:0071715)4.71901781
26epithelial structure maintenance (GO:0010669)4.69305717
27limb bud formation (GO:0060174)4.59065673
28fatty acid derivative biosynthetic process (GO:1901570)4.57711446
29icosanoid biosynthetic process (GO:0046456)4.57711446
30regulation of Rap GTPase activity (GO:0032317)4.56408335
31transcription elongation from RNA polymerase III promoter (GO:0006385)4.50040927
32termination of RNA polymerase III transcription (GO:0006386)4.50040927
33ATP synthesis coupled proton transport (GO:0015986)4.40065158
34energy coupled proton transport, down electrochemical gradient (GO:0015985)4.40065158
35low-density lipoprotein particle remodeling (GO:0034374)4.34043309
36nephron tubule formation (GO:0072079)4.33415899
37regulation of gene silencing by RNA (GO:0060966)4.30627211
38regulation of posttranscriptional gene silencing (GO:0060147)4.30627211
39regulation of gene silencing by miRNA (GO:0060964)4.30627211
40positive regulation of fatty acid beta-oxidation (GO:0032000)4.22329113
41maturation of SSU-rRNA (GO:0030490)4.21631167
42endocardial cushion morphogenesis (GO:0003203)4.14174474
43regulation of glycogen (starch) synthase activity (GO:2000465)4.13257020
44chaperone-mediated protein transport (GO:0072321)4.10143183
45positive regulation of extracellular matrix organization (GO:1903055)4.09490452
46leukotriene biosynthetic process (GO:0019370)4.09254719
47termination of signal transduction (GO:0023021)4.03761410
48positive regulation of male gonad development (GO:2000020)4.03274727
49regulation of interleukin-8 secretion (GO:2000482)4.00388070
50cellular response to antibiotic (GO:0071236)3.98535152
51long term synaptic depression (GO:0060292)3.98524139
52behavioral response to nicotine (GO:0035095)3.95533799
53termination of G-protein coupled receptor signaling pathway (GO:0038032)3.94087935
54phosphorylated carbohydrate dephosphorylation (GO:0046838)3.89914927
55inositol phosphate dephosphorylation (GO:0046855)3.89914927
56regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.89547158
57inner mitochondrial membrane organization (GO:0007007)3.79597445
58membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.78245277
59ribosomal small subunit biogenesis (GO:0042274)3.77212429
60mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.75266475
61regulation of male gonad development (GO:2000018)3.74650684
62viral transcription (GO:0019083)3.74623232
63carnitine shuttle (GO:0006853)3.69692311
64regulation of T-helper 2 cell differentiation (GO:0045628)3.68638297
65cardiolipin metabolic process (GO:0032048)3.68052257
66translational termination (GO:0006415)3.67931193
67skin morphogenesis (GO:0043589)3.67821385
68respiratory electron transport chain (GO:0022904)3.67627382
69notochord development (GO:0030903)3.66952646
70electron transport chain (GO:0022900)3.64265770
71protein complex biogenesis (GO:0070271)3.64087880
72regulation of translational termination (GO:0006449)3.63544957
73intestinal epithelial cell development (GO:0060576)3.63221687
74arachidonic acid metabolic process (GO:0019369)3.63146004
75inositol phosphate catabolic process (GO:0071545)3.61835027
76regulation of mitochondrial translation (GO:0070129)3.61343670
77membrane repolarization during action potential (GO:0086011)3.56851844
78mitochondrial respiratory chain complex assembly (GO:0033108)3.55266676
79cyclooxygenase pathway (GO:0019371)3.53484590
80intra-S DNA damage checkpoint (GO:0031573)3.49853733
81protein-cofactor linkage (GO:0018065)3.48387104
82phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.46352729
83positive regulation of cellular response to insulin stimulus (GO:1900078)3.45648790
84regulation of vesicle fusion (GO:0031338)3.45618735
85mitochondrial respiratory chain complex I assembly (GO:0032981)3.42294373
86NADH dehydrogenase complex assembly (GO:0010257)3.42294373
87mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.42294373
88regulation of centriole replication (GO:0046599)3.41607622
89regulation of nuclear cell cycle DNA replication (GO:0033262)3.39486746
90negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.38047913
91heart valve formation (GO:0003188)3.36472617
92negative regulation of interleukin-8 production (GO:0032717)3.35714014
93membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.34636313
94ribosomal large subunit biogenesis (GO:0042273)3.29990002
95chromatin remodeling at centromere (GO:0031055)3.28140055
96negative regulation of bone mineralization (GO:0030502)3.25636961
97DNA deamination (GO:0045006)3.24134546
98long-chain fatty acid transport (GO:0015909)3.22700385
99adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)3.21826446
100regulation of T cell cytokine production (GO:0002724)3.19564885
101fatty acid transmembrane transport (GO:1902001)3.17338919
102vitamin biosynthetic process (GO:0009110)3.17152413
103cellular response to toxic substance (GO:0097237)3.15865618
104negative regulation of glycogen biosynthetic process (GO:0045719)3.13866349
105glycerophospholipid catabolic process (GO:0046475)3.13621339
106translational elongation (GO:0006414)3.13441531
107intracellular protein transmembrane import (GO:0044743)3.13390774
108positive regulation of fatty acid oxidation (GO:0046321)3.10671801
109prostaglandin biosynthetic process (GO:0001516)3.09876981
110prostanoid biosynthetic process (GO:0046457)3.09876981
111phospholipid scrambling (GO:0017121)3.08008763
112sensory perception of chemical stimulus (GO:0007606)3.07135301
113CENP-A containing nucleosome assembly (GO:0034080)3.06078144
114urinary tract smooth muscle contraction (GO:0014848)3.05942283
115cotranslational protein targeting to membrane (GO:0006613)3.05381536
116protein neddylation (GO:0045116)3.05255981
117vesicle targeting (GO:0006903)3.05084303
118phosphatidylcholine acyl-chain remodeling (GO:0036151)3.04634858
119SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.04411660
120negative regulation of DNA-dependent DNA replication (GO:2000104)3.00945920
121protein targeting to ER (GO:0045047)2.99864753
122ribosomal small subunit assembly (GO:0000028)2.99606761
123fat-soluble vitamin catabolic process (GO:0042363)2.96703015
124vitamin catabolic process (GO:0009111)2.96703015
125negative regulation of glycogen metabolic process (GO:0070874)2.94619562
126negative regulation of acute inflammatory response (GO:0002674)2.94518637
127positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.94254478
128carnitine metabolic process (GO:0009437)2.93968286
129mast cell degranulation (GO:0043303)2.91248978
130mast cell activation involved in immune response (GO:0002279)2.91248978
131phosphatidylserine metabolic process (GO:0006658)2.90977274
132biotin metabolic process (GO:0006768)2.89933801
133platelet dense granule organization (GO:0060155)2.89198128
134sequestering of actin monomers (GO:0042989)2.87847931
135establishment of protein localization to endoplasmic reticulum (GO:0072599)2.87693938
136secondary heart field specification (GO:0003139)2.87329856
137heart field specification (GO:0003128)2.87329856
138oligodendrocyte differentiation (GO:0048709)2.87313735
139carnitine transmembrane transport (GO:1902603)2.87000454
140cellular protein complex disassembly (GO:0043624)2.85744924
141galactose catabolic process (GO:0019388)2.85023215
142negative regulation of biomineral tissue development (GO:0070168)2.84952260
143regulation of mesenchymal cell apoptotic process (GO:2001053)2.83211806
144nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.82808263
145positive regulation of filopodium assembly (GO:0051491)2.82664956
146phosphatidylcholine metabolic process (GO:0046470)2.81902391
147rRNA modification (GO:0000154)2.80277876
148natural killer cell mediated cytotoxicity (GO:0042267)2.79988400
149natural killer cell mediated immunity (GO:0002228)2.79988400
150viral life cycle (GO:0019058)2.79956786
151DNA ligation (GO:0006266)2.79527464
152diacylglycerol metabolic process (GO:0046339)2.79258325
153mesenchyme morphogenesis (GO:0072132)2.78340717
154phospholipid catabolic process (GO:0009395)2.77232716
155long-term synaptic potentiation (GO:0060291)2.76860894
156protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)2.75905801
157response to nicotine (GO:0035094)2.75114755
158protein localization to endoplasmic reticulum (GO:0070972)2.74737710
159negative regulation by host of viral transcription (GO:0043922)2.73581419
160telomere maintenance via telomerase (GO:0007004)2.73376775
161histone exchange (GO:0043486)2.73063834
162negative regulation of G-protein coupled receptor protein signaling pathway (GO:0045744)2.71922513
163polyol catabolic process (GO:0046174)2.71547424
164nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.69597028
165regulation of transcription from RNA polymerase I promoter (GO:0006356)2.69548043
166negative regulation of gene silencing (GO:0060969)2.69058924
167hydrogen ion transmembrane transport (GO:1902600)2.67682302
168transcription from RNA polymerase III promoter (GO:0006383)2.67626365
169translational initiation (GO:0006413)2.65346677
1707-methylguanosine mRNA capping (GO:0006370)2.63348893
171establishment of integrated proviral latency (GO:0075713)2.60604634
172exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.60549378
173intracellular protein transmembrane transport (GO:0065002)2.59643966
174transepithelial transport (GO:0070633)2.59192530
1757-methylguanosine RNA capping (GO:0009452)2.57460488
176RNA capping (GO:0036260)2.57460488
177attachment of spindle microtubules to kinetochore (GO:0008608)2.56898517
178generation of neurons (GO:0048699)2.56688384
179transcription from RNA polymerase I promoter (GO:0006360)2.53945730
180regulation of cellular respiration (GO:0043457)2.52928463
181rRNA methylation (GO:0031167)2.52049343
182DNA catabolic process, exonucleolytic (GO:0000738)2.51808117
183aerobic respiration (GO:0009060)2.51802134
184synaptic transmission, cholinergic (GO:0007271)2.49741097
185positive regulation of transcription regulatory region DNA binding (GO:2000679)2.48095405
186protein complex disassembly (GO:0043241)2.47565613
187mitochondrion morphogenesis (GO:0070584)2.47246769
188copper ion transport (GO:0006825)2.45842997
189single strand break repair (GO:0000012)2.44910675
190inner ear receptor cell development (GO:0060119)2.44029547
191regulation of mesoderm development (GO:2000380)2.42580336
192potassium ion import (GO:0010107)2.42342026
193protein localization to synapse (GO:0035418)2.39402428
194rRNA processing (GO:0006364)2.39191268
195postreplication repair (GO:0006301)2.38568162
196negative regulation of T cell differentiation in thymus (GO:0033085)2.38044384
197membrane repolarization (GO:0086009)2.36565127
198replication fork processing (GO:0031297)2.36232537
199detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)10.8772133

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human4.55510868
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.31952054
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.83721756
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.75911033
5EZH2_22144423_ChIP-Seq_EOC_Human3.43051907
6AR_21572438_ChIP-Seq_LNCaP_Human3.38993418
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.28563547
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.27876827
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.25908538
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.80714346
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69834483
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.69751908
13VDR_22108803_ChIP-Seq_LS180_Human2.66911562
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.60110614
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.48943031
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.46596407
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.45322110
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.33112264
19IRF1_19129219_ChIP-ChIP_H3396_Human2.21505972
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.19894664
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13511943
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.13471136
23ESR1_15608294_ChIP-ChIP_MCF-7_Human2.11617146
24ETS1_20019798_ChIP-Seq_JURKAT_Human2.11551903
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.09538884
26FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.07067788
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.05051603
28JARID2_20075857_ChIP-Seq_MESCs_Mouse2.04357813
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.03658997
30E2F4_17652178_ChIP-ChIP_JURKAT_Human2.01668007
31ELK1_19687146_ChIP-ChIP_HELA_Human1.97070749
32DROSHA_22980978_ChIP-Seq_HELA_Human1.95883721
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.94160161
34TP53_18474530_ChIP-ChIP_U2OS_Human1.93926628
35ZNF274_21170338_ChIP-Seq_K562_Hela1.92130976
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.91460749
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.87779696
38ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.87285655
39MYC_18940864_ChIP-ChIP_HL60_Human1.85078699
40GBX2_23144817_ChIP-Seq_PC3_Human1.84665118
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83210795
42JARID2_20064375_ChIP-Seq_MESCs_Mouse1.82957027
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.81026187
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78766236
45SOX2_16153702_ChIP-ChIP_HESCs_Human1.77249971
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74579668
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74508748
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.72439060
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70024243
50HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.69994200
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69988753
52STAT1_20625510_ChIP-Seq_HELA_Human1.68278396
53TRIM28_21343339_ChIP-Seq_HEK293_Human1.65553982
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.64273402
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.63860509
56EZH2_18974828_ChIP-Seq_MESCs_Mouse1.63860509
57XRN2_22483619_ChIP-Seq_HELA_Human1.62354428
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60587196
59MYC_19030024_ChIP-ChIP_MESCs_Mouse1.60072893
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59733522
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59214173
62MYC_19079543_ChIP-ChIP_MESCs_Mouse1.58536346
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.57766176
64KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.57766176
65KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.57766176
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.57626739
67PPAR_26484153_Chip-Seq_NCI-H1993_Human1.57279782
68TTF2_22483619_ChIP-Seq_HELA_Human1.55887802
69EWS_26573619_Chip-Seq_HEK293_Human1.55143048
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.54482145
71CDX2_20551321_ChIP-Seq_CACO-2_Human1.46959495
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46409972
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.45982211
74TAF15_26573619_Chip-Seq_HEK293_Human1.45822132
75SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.44285267
76EZH2_27304074_Chip-Seq_ESCs_Mouse1.43571311
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43381686
78EED_16625203_ChIP-ChIP_MESCs_Mouse1.39883321
79VDR_23849224_ChIP-Seq_CD4+_Human1.39800379
80NANOG_16153702_ChIP-ChIP_HESCs_Human1.37791257
81MYC_18358816_ChIP-ChIP_MESCs_Mouse1.37608039
82AHR_22903824_ChIP-Seq_MCF-7_Human1.36185429
83NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.35192619
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34748474
85FUS_26573619_Chip-Seq_HEK293_Human1.32504718
86PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.32250550
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.30871615
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29698378
89YY1_21170310_ChIP-Seq_MESCs_Mouse1.29651586
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28634372
91* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28217312
92GATA1_26923725_Chip-Seq_HPCs_Mouse1.27172230
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23609994
94SMAD4_21799915_ChIP-Seq_A2780_Human1.21871585
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19903494
96P300_19829295_ChIP-Seq_ESCs_Human1.19422769
97IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18462998
98GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18423513
99TP53_20018659_ChIP-ChIP_R1E_Mouse1.18074928
100AR_25329375_ChIP-Seq_VCAP_Human1.17908929
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.17904406
102FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17742471
103RNF2_27304074_Chip-Seq_ESCs_Mouse1.16846295
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16799550
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.14872952
106ELK4_26923725_Chip-Seq_MESODERM_Mouse1.14585192
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13172634
108NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12656060
109WT1_19549856_ChIP-ChIP_CCG9911_Human1.12375922
110SOX2_20726797_ChIP-Seq_SW620_Human1.11285511
111ERG_21242973_ChIP-ChIP_JURKAT_Human1.10836823
112RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10746886
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10420380
114REST_21632747_ChIP-Seq_MESCs_Mouse1.10405555
115CTCF_27219007_Chip-Seq_Bcells_Human1.09273822
116GATA4_25053715_ChIP-Seq_YYC3_Human1.08985927
117RNF2_27304074_Chip-Seq_NSC_Mouse1.08732665
118ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08589868
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08294973
120TP53_16413492_ChIP-PET_HCT116_Human1.07543435
121POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05995271
122LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05950351
123SMAD3_21741376_ChIP-Seq_ESCs_Human1.05886176
124E2F7_22180533_ChIP-Seq_HELA_Human1.05527892
125RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05213714
126ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03859245
127PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03552848
128SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02917035
129E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02837490
130JUN_21703547_ChIP-Seq_K562_Human1.02516783
131SMAD3_21741376_ChIP-Seq_EPCs_Human1.02491850
132ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02457869
133NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.02434148
134CBX2_27304074_Chip-Seq_ESCs_Mouse1.02087628
135LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01811529
136GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00958484
137ER_23166858_ChIP-Seq_MCF-7_Human1.00579555
138FOXP3_21729870_ChIP-Seq_TREG_Human0.99754120
139ESR1_20079471_ChIP-ChIP_T-47D_Human0.99183636
140CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97590205
141POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97463254
142ELK1_22589737_ChIP-Seq_MCF10A_Human0.97025620
143RING1B_27294783_Chip-Seq_ESCs_Mouse0.96908246
144NOTCH1_21737748_ChIP-Seq_TLL_Human0.96898568
145E2F1_21310950_ChIP-Seq_MCF-7_Human0.96100986
146SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96093640
147RXR_22108803_ChIP-Seq_LS180_Human0.96040035
148SOX2_19829295_ChIP-Seq_ESCs_Human0.95980687
149NANOG_19829295_ChIP-Seq_ESCs_Human0.95980687
150PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95877863
151GF1B_26923725_Chip-Seq_HPCs_Mouse0.95541143
152TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95496286
153SMAD4_21741376_ChIP-Seq_HESCs_Human0.95314832
154TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94821297
155MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94043000
156RUNX1_27514584_Chip-Seq_MCF-7_Human0.93349523
157KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93310995
158IGF1R_20145208_ChIP-Seq_DFB_Human0.93001146
159FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92913410
160RING1B_27294783_Chip-Seq_NPCs_Mouse0.92236351
161PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91950247
162GF1_26923725_Chip-Seq_HPCs_Mouse0.91837615
163ESR2_21235772_ChIP-Seq_MCF-7_Human0.91623182
164NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91242931
165SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.90634160
166DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90213523
167CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90146642
168FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.90123632
169MYC_27129775_Chip-Seq_CORNEA_Mouse0.89701453
170* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89001512
171NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88744519
172TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.88536555
173TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88164176
174POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88164176
175GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.87917404
176SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87503273
177DCP1A_22483619_ChIP-Seq_HELA_Human0.87466725
178KAP1_22055183_ChIP-Seq_ESCs_Mouse0.87203224
179ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.87011236
180GATA3_21878914_ChIP-Seq_MCF-7_Human0.85476086
181FLI1_27457419_Chip-Seq_LIVER_Mouse0.83603528
182SRF_21415370_ChIP-Seq_HL-1_Mouse0.83538335
183FOXA1_27270436_Chip-Seq_PROSTATE_Human0.77574678
184FOXA1_25329375_ChIP-Seq_VCAP_Human0.77574678
185CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.76323036
186AR_21909140_ChIP-Seq_LNCAP_Human0.75734404
187TDRD3_21172665_ChIP-Seq_MCF-7_Human0.75129219
188HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.75077793

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ5.45192544
2MP0008004_abnormal_stomach_pH5.26232470
3MP0002148_abnormal_hypersensitivity_rea4.72286228
4MP0009379_abnormal_foot_pigmentation4.27122877
5MP0000490_abnormal_crypts_of3.24871672
6MP0002736_abnormal_nociception_after3.24590808
7MP0004147_increased_porphyrin_level3.18961534
8MP0001968_abnormal_touch/_nociception2.70070250
9MP0001188_hyperpigmentation2.59618066
10MP0003890_abnormal_embryonic-extraembry2.42966424
11MP0003693_abnormal_embryo_hatching2.38924787
12MP0003315_abnormal_perineum_morphology2.35033522
13MP0001485_abnormal_pinna_reflex2.24398476
14MP0003718_maternal_effect2.19911203
15MP0003119_abnormal_digestive_system2.15702303
16MP0003567_abnormal_fetal_cardiomyocyte2.03273137
17MP0000538_abnormal_urinary_bladder2.02098488
18MP0001986_abnormal_taste_sensitivity12.4952309
19MP0001666_abnormal_nutrient_absorption1.90949236
20MP0002938_white_spotting1.88853194
21MP0000631_abnormal_neuroendocrine_gland1.88280854
22MP0010155_abnormal_intestine_physiology1.87766106
23MP0006292_abnormal_olfactory_placode1.87343004
24MP0006072_abnormal_retinal_apoptosis1.78610874
25MP0003937_abnormal_limbs/digits/tail_de1.77144021
26MP0005360_urolithiasis1.74981409
27MP0004957_abnormal_blastocyst_morpholog1.72944127
28MP0003136_yellow_coat_color1.69499091
29MP0005377_hearing/vestibular/ear_phenot1.69198873
30MP0003878_abnormal_ear_physiology1.69198873
31MP0004742_abnormal_vestibular_system1.67967814
32MP0001293_anophthalmia1.67516785
33MP0005395_other_phenotype1.66446951
34MP0003938_abnormal_ear_development1.65610105
35MP0003880_abnormal_central_pattern1.64034948
36MP0002102_abnormal_ear_morphology1.63140772
37MP0004859_abnormal_synaptic_plasticity1.59805192
38MP0004885_abnormal_endolymph1.57882851
39MP0002751_abnormal_autonomic_nervous1.55275984
40MP0005646_abnormal_pituitary_gland1.44347541
41MP0001664_abnormal_digestion1.41625952
42MP0003787_abnormal_imprinting1.41524957
43MP0001764_abnormal_homeostasis1.39410683
44MP0004142_abnormal_muscle_tone1.37479801
45MP0010386_abnormal_urinary_bladder1.36044472
46MP0002249_abnormal_larynx_morphology1.35916714
47MP0009780_abnormal_chondrocyte_physiolo1.35420680
48MP0002254_reproductive_system_inflammat1.33417993
49MP0002138_abnormal_hepatobiliary_system1.32556089
50MP0003638_abnormal_response/metabolism_1.31778873
51MP0004264_abnormal_extraembryonic_tissu1.30394964
52MP0005423_abnormal_somatic_nervous1.30070703
53MP0004270_analgesia1.29448739
54MP0002168_other_aberrant_phenotype1.29232148
55MP0001501_abnormal_sleep_pattern1.26761183
56MP0003436_decreased_susceptibility_to1.23475577
57MP0000477_abnormal_intestine_morphology1.20636440
58MP0008007_abnormal_cellular_replicative1.18319498
59MP0001905_abnormal_dopamine_level1.15483349
60MP0008260_abnormal_autophagy1.14349790
61MP0005645_abnormal_hypothalamus_physiol1.11418473
62MP0003868_abnormal_feces_composition1.11318713
63MP0002733_abnormal_thermal_nociception1.11037494
64MP0004043_abnormal_pH_regulation1.09754715
65MP0008874_decreased_physiological_sensi1.09532990
66MP0002111_abnormal_tail_morphology1.09406330
67MP0000566_synostosis1.08889073
68MP0003111_abnormal_nucleus_morphology1.07677290
69MP0003941_abnormal_skin_development1.07495190
70MP0002139_abnormal_hepatobiliary_system1.07346335
71MP0009046_muscle_twitch1.06191461
72MP0001486_abnormal_startle_reflex1.05342483
73MP0003635_abnormal_synaptic_transmissio1.05301229
74MP0002735_abnormal_chemical_nociception1.05022340
75MP0003879_abnormal_hair_cell1.04872719
76MP0004134_abnormal_chest_morphology1.03891429
77MP0003077_abnormal_cell_cycle1.03780930
78MP0002295_abnormal_pulmonary_circulatio1.03194456
79MP0002909_abnormal_adrenal_gland1.02874383
80MP0004036_abnormal_muscle_relaxation1.01285755
81MP0005023_abnormal_wound_healing0.97384092
82MP0008932_abnormal_embryonic_tissue0.96803771
83MP0000026_abnormal_inner_ear0.94317008
84MP0006138_congestive_heart_failure0.94100112
85MP0002234_abnormal_pharynx_morphology0.93876355
86MP0010030_abnormal_orbit_morphology0.92376376
87MP0000462_abnormal_digestive_system0.91341412
88MP0009250_abnormal_appendicular_skeleto0.90159148
89MP0002697_abnormal_eye_size0.90056819
90MP0002557_abnormal_social/conspecific_i0.89138112
91MP0008058_abnormal_DNA_repair0.88776312
92MP0005000_abnormal_immune_tolerance0.88579292
93MP0009765_abnormal_xenobiotic_induced0.88485456
94MP0004858_abnormal_nervous_system0.88472215
95MP0002876_abnormal_thyroid_physiology0.88428320
96MP0000537_abnormal_urethra_morphology0.87372333
97MP0001529_abnormal_vocalization0.86873388
98MP0002405_respiratory_system_inflammati0.86518614
99MP0002282_abnormal_trachea_morphology0.85708058
100MP0001346_abnormal_lacrimal_gland0.85698569
101MP0002653_abnormal_ependyma_morphology0.85127678
102MP0005174_abnormal_tail_pigmentation0.84390739
103MP0002572_abnormal_emotion/affect_behav0.84083560
104MP0005253_abnormal_eye_physiology0.83482221
105MP0002067_abnormal_sensory_capabilities0.83301899
106MP0008057_abnormal_DNA_replication0.83207726
107MP0001348_abnormal_lacrimal_gland0.83057802
108MP0002734_abnormal_mechanical_nocicepti0.82977002
109MP0003861_abnormal_nervous_system0.82308163
110MP0002084_abnormal_developmental_patter0.82244491
111MP0002085_abnormal_embryonic_tissue0.80738550
112MP0001970_abnormal_pain_threshold0.80584207
113MP0002063_abnormal_learning/memory/cond0.80212139
114MP0004133_heterotaxia0.79784572
115MP0004484_altered_response_of0.78307500
116MP0008872_abnormal_physiological_respon0.77880381
117MP0004019_abnormal_vitamin_homeostasis0.77288333
118MP0003252_abnormal_bile_duct0.77162747
119MP0005085_abnormal_gallbladder_physiolo0.77034044
120MP0003195_calcinosis0.76969447
121MP0009697_abnormal_copulation0.76546324
122MP0005332_abnormal_amino_acid0.75499516
123MP0010329_abnormal_lipoprotein_level0.74955676
124MP0002272_abnormal_nervous_system0.74811239
125MP0000049_abnormal_middle_ear0.74689203
126MP0001286_abnormal_eye_development0.74080995
127MP0003385_abnormal_body_wall0.73894447
128MP0003122_maternal_imprinting0.73278157
129MP0003755_abnormal_palate_morphology0.73252585
130MP0000534_abnormal_ureter_morphology0.73203162
131MP0005365_abnormal_bile_salt0.72363570
132MP0003183_abnormal_peptide_metabolism0.72012780
133MP0002210_abnormal_sex_determination0.71937532
134MP0008875_abnormal_xenobiotic_pharmacok0.71790935
135MP0001943_abnormal_respiration0.71602290
136MP0002822_catalepsy0.71317499
137MP0003011_delayed_dark_adaptation0.71252740
138MP0003806_abnormal_nucleotide_metabolis0.71135360
139MP0002064_seizures0.70694862
140MP0003942_abnormal_urinary_system0.70234076
141MP0002752_abnormal_somatic_nervous0.68950312
142MP0003221_abnormal_cardiomyocyte_apopto0.68942032
143MP0002160_abnormal_reproductive_system0.68005573
144MP0005379_endocrine/exocrine_gland_phen0.67655736
145MP0002396_abnormal_hematopoietic_system0.67491057
146MP0001963_abnormal_hearing_physiology0.66814512
147MP0008877_abnormal_DNA_methylation0.66455806
148MP0000427_abnormal_hair_cycle0.66425338
149MP0005551_abnormal_eye_electrophysiolog0.66380142
150MP0001919_abnormal_reproductive_system0.66165186
151MP0005389_reproductive_system_phenotype0.65862704
152MP0002089_abnormal_postnatal_growth/wei0.65815918
153MP0001177_atelectasis0.65043058
154MP0003075_altered_response_to0.63537931
155MP0002233_abnormal_nose_morphology0.61245179
156MP0002277_abnormal_respiratory_mucosa0.60176982
157MP0005623_abnormal_meninges_morphology0.59713334
158MP0009745_abnormal_behavioral_response0.59486242
159MP0006276_abnormal_autonomic_nervous0.59070666
160MP0005464_abnormal_platelet_physiology0.58583278
161MP0009763_increased_sensitivity_to0.57167994
162MP0001765_abnormal_ion_homeostasis0.56989451
163MP0002118_abnormal_lipid_homeostasis0.56756495
164MP0000013_abnormal_adipose_tissue0.55394600
165MP0003866_abnormal_defecation0.55234986
166MP0005410_abnormal_fertilization0.54722367
167MP0000778_abnormal_nervous_system0.54361271
168MP0001533_abnormal_skeleton_physiology0.54240364
169MP0005165_increased_susceptibility_to0.53605290
170MP0004085_abnormal_heartbeat0.53106054
171MP0000762_abnormal_tongue_morphology0.52474196

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)5.76931980
2True hermaphroditism (HP:0010459)5.48756977
3Neonatal short-limb short stature (HP:0008921)5.03954931
4Abnormal sex determination (HP:0012244)4.97003213
5Sex reversal (HP:0012245)4.97003213
611 pairs of ribs (HP:0000878)4.89850334
7Increased hepatocellular lipid droplets (HP:0006565)4.70127079
8Aplasia/Hypoplasia of the sternum (HP:0006714)4.67464699
9Gait imbalance (HP:0002141)4.50246780
10Congenital primary aphakia (HP:0007707)4.34009779
11Bronchomalacia (HP:0002780)4.16759494
12Lipid accumulation in hepatocytes (HP:0006561)4.14274427
13Focal motor seizures (HP:0011153)4.06736414
14Vaginal atresia (HP:0000148)3.99658158
15Chronic sinusitis (HP:0011109)3.95568612
16Genital tract atresia (HP:0001827)3.95486110
17Renal Fanconi syndrome (HP:0001994)3.78132074
18Medial flaring of the eyebrow (HP:0010747)3.71590002
19Vascular calcification (HP:0004934)3.68142715
20Peripheral hypomyelination (HP:0007182)3.66431464
21Nephrogenic diabetes insipidus (HP:0009806)3.63547919
22Chronic hepatic failure (HP:0100626)3.57547767
23Abnormal gallbladder physiology (HP:0012438)3.55681932
24Cholecystitis (HP:0001082)3.55681932
25Respiratory distress (HP:0002098)3.47855835
26Decreased central vision (HP:0007663)3.37301725
27Reticulocytopenia (HP:0001896)3.34813442
28Abnormal number of erythroid precursors (HP:0012131)3.32776375
29Cardiovascular calcification (HP:0011915)3.31671478
30Acute necrotizing encephalopathy (HP:0006965)3.29910205
31Micronodular cirrhosis (HP:0001413)3.29496678
32Poor coordination (HP:0002370)3.28909983
33Megalencephaly (HP:0001355)3.22915294
34Upper limb muscle weakness (HP:0003484)3.21220217
35Congenital, generalized hypertrichosis (HP:0004540)3.18853141
36Mitochondrial inheritance (HP:0001427)3.17932078
37Clumsiness (HP:0002312)3.15400003
38Colon cancer (HP:0003003)3.02437112
39Bundle branch block (HP:0011710)3.00116370
40Abnormality of cells of the erythroid lineage (HP:0012130)2.98954508
41Acute encephalopathy (HP:0006846)2.96757691
42Prolonged QT interval (HP:0001657)2.93672324
43Fibular hypoplasia (HP:0003038)2.92245758
44Methylmalonic acidemia (HP:0002912)2.90451606
45Hypokinesia (HP:0002375)2.90436664
46Scanning speech (HP:0002168)2.87485305
47Distal lower limb muscle weakness (HP:0009053)2.80595623
48Macrocytic anemia (HP:0001972)2.79667298
49Recurrent gram-negative bacterial infections (HP:0005420)2.77749239
50Visual hallucinations (HP:0002367)2.77381138
51Progressive macrocephaly (HP:0004481)2.73842992
52Esophageal varix (HP:0002040)2.73308510
53Abnormal vertebral ossification (HP:0100569)2.71139316
54Missing ribs (HP:0000921)2.70636675
55Type II lissencephaly (HP:0007260)2.70491247
56Aplasia/Hypoplasia of the scapulae (HP:0006713)2.69707179
57Hypoplastic scapulae (HP:0000882)2.69707179
58Limb dystonia (HP:0002451)2.69510025
59Abnormal mitochondria in muscle tissue (HP:0008316)2.68156150
60Bradycardia (HP:0001662)2.67287960
61Methylmalonic aciduria (HP:0012120)2.67284117
62Abnormal ciliary motility (HP:0012262)2.67066622
63Tibial bowing (HP:0002982)2.64033765
64Abnormal respiratory motile cilium physiology (HP:0012261)2.61664847
65Exertional dyspnea (HP:0002875)2.60896314
66Optic nerve hypoplasia (HP:0000609)2.59282019
67Abnormality of renal resorption (HP:0011038)2.57086834
68Aplasia/Hypoplasia of the lens (HP:0008063)2.54054001
69Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.52963455
70Ketoacidosis (HP:0001993)2.52691111
71Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.50636768
72Increased CSF lactate (HP:0002490)2.48865899
73Glycosuria (HP:0003076)2.46486910
74Abnormality of urine glucose concentration (HP:0011016)2.46486910
75Depressed nasal tip (HP:0000437)2.46148882
76Decreased muscle mass (HP:0003199)2.45723858
77Abnormal urine phosphate concentration (HP:0012599)2.43978567
78Hyperglycinuria (HP:0003108)2.43585200
79Pendular nystagmus (HP:0012043)2.42761704
80Progressive external ophthalmoplegia (HP:0000590)2.42743554
81Septo-optic dysplasia (HP:0100842)2.41855523
82Male pseudohermaphroditism (HP:0000037)2.38554285
83Syncope (HP:0001279)2.37624653
84Interstitial pulmonary disease (HP:0006530)2.34239823
85Pancreatic fibrosis (HP:0100732)2.33775826
86Ulnar claw (HP:0001178)2.32699319
87Supranuclear gaze palsy (HP:0000605)2.28748622
88Abnormality of the pons (HP:0007361)2.28496555
89Abnormality of the vitamin B12 metabolism (HP:0004341)2.27744443
90Mitral stenosis (HP:0001718)2.27447034
91Short clavicles (HP:0000894)2.27369598
92Increased intramyocellular lipid droplets (HP:0012240)2.26993869
93Broad foot (HP:0001769)2.26213632
94Confusion (HP:0001289)2.24977913
95Pancreatic cysts (HP:0001737)2.24350310
96Hyperphosphaturia (HP:0003109)2.23568150
97Progressive neurologic deterioration (HP:0002344)2.23245040
98Pheochromocytoma (HP:0002666)2.22929309
99Large for gestational age (HP:0001520)2.22698019
100Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.21878003
101Abnormality of liposaccharide metabolism (HP:0010968)2.21683934
102Abnormality of glycosphingolipid metabolism (HP:0004343)2.21683934
103Abnormality of glycolipid metabolism (HP:0010969)2.21683934
104Abnormality of vitamin B metabolism (HP:0004340)2.20100285
105Bilateral microphthalmos (HP:0007633)2.18993739
106Short hallux (HP:0010109)2.18387786
107Left ventricular hypertrophy (HP:0001712)2.16604584
108Birth length less than 3rd percentile (HP:0003561)2.16250250
109Absent eyebrow (HP:0002223)2.16160030
110Neuroendocrine neoplasm (HP:0100634)2.15951701
111Hyperglycinemia (HP:0002154)2.15557506
112Cone-rod dystrophy (HP:0000548)2.14729722
113Hypoplasia of the pons (HP:0012110)2.14300666
114Curly hair (HP:0002212)2.14208573
115Tracheomalacia (HP:0002779)2.12158186
116Vertebral hypoplasia (HP:0008417)2.10242488
117Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.10242488
118Abnormality of homocysteine metabolism (HP:0010919)2.10163155
119Homocystinuria (HP:0002156)2.10163155
120Aplasia/Hypoplasia of the patella (HP:0006498)2.10028957
121Ventricular arrhythmia (HP:0004308)2.08264899
122Aplasia/Hypoplasia of the clavicles (HP:0006710)2.07819534
123Akinesia (HP:0002304)2.06368921
124Partial duplication of the phalanx of hand (HP:0009999)2.03045676
125Abnormality of the labia minora (HP:0012880)2.02818101
126Abnormal respiratory epithelium morphology (HP:0012253)2.02179644
127Abnormal respiratory motile cilium morphology (HP:0005938)2.02179644
128Aplasia/Hypoplasia involving the musculature (HP:0001460)2.00338477
129Bifid scrotum (HP:0000048)2.00207219
130Hepatoblastoma (HP:0002884)1.99063006
131Furrowed tongue (HP:0000221)1.98810354
132Specific learning disability (HP:0001328)1.98619537
133Abdominal distention (HP:0003270)1.98296432
134Partial duplication of thumb phalanx (HP:0009944)1.98192215
135Cerebellar dysplasia (HP:0007033)1.97311175
136Aplasia/Hypoplasia of the hallux (HP:0008362)1.95783808
137Abnormal lung lobation (HP:0002101)1.94763969
138Abnormality of glycine metabolism (HP:0010895)1.94728237
139Abnormality of serine family amino acid metabolism (HP:0010894)1.94728237
140Osteomalacia (HP:0002749)1.94680769
141Abnormality of the right ventricle (HP:0001707)1.92019338
142Glucose intolerance (HP:0000833)1.91859567
143Cerebral edema (HP:0002181)1.91454389
144Glossoptosis (HP:0000162)1.90911562
145Supernumerary spleens (HP:0009799)1.90821871
146Nephronophthisis (HP:0000090)1.90393279
147Maternal diabetes (HP:0009800)1.89589340
148J-shaped sella turcica (HP:0002680)1.89416715
149Intestinal atresia (HP:0011100)1.88541707
150Focal seizures (HP:0007359)1.87925035
151Epiphyseal dysplasia (HP:0002656)1.87923549
152Absent eyelashes (HP:0000561)1.87707724
153Patellar aplasia (HP:0006443)1.87432547
154Coxa valga (HP:0002673)1.86803698
155Cortical visual impairment (HP:0100704)1.86725929
156Scrotal hypoplasia (HP:0000046)1.86103114
157Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.85652709
158Seborrheic dermatitis (HP:0001051)1.85488348
159Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85471725
160Choanal stenosis (HP:0000452)1.84667975
161Relative macrocephaly (HP:0004482)1.84281405
162Paralysis (HP:0003470)1.83521517
163Hepatocellular necrosis (HP:0001404)1.83470788
164Impulsivity (HP:0100710)1.83384622
165Abnormal number of incisors (HP:0011064)1.82922790
166Aplastic anemia (HP:0001915)1.81645752
167Morphological abnormality of the middle ear (HP:0008609)1.80767394
168Rhinitis (HP:0012384)1.80469242
169Generalized tonic-clonic seizures (HP:0002069)1.78651673
170Increased muscle lipid content (HP:0009058)1.78491326
171Sclerocornea (HP:0000647)1.78432038
172Abnormality of serum amino acid levels (HP:0003112)1.78019913
173Abnormality of methionine metabolism (HP:0010901)1.75825024
174Molar tooth sign on MRI (HP:0002419)1.75704448
175Abnormality of midbrain morphology (HP:0002418)1.75704448
176Renal tubular dysfunction (HP:0000124)1.73578315
177Holoprosencephaly (HP:0001360)1.71990344
178Anophthalmia (HP:0000528)1.70392341
179Hypogonadotrophic hypogonadism (HP:0000044)1.70228690
180Abnormality of sulfur amino acid metabolism (HP:0004339)1.68939468
181Leukodystrophy (HP:0002415)1.68905445
182Respiratory difficulties (HP:0002880)1.68898516
183Abnormality of the renal medulla (HP:0100957)1.68527087
184Intestinal polyposis (HP:0200008)1.68294180
185Lethargy (HP:0001254)1.67485783
186Optic disc pallor (HP:0000543)1.67075670
187Neoplasm of the colon (HP:0100273)1.66806422
188Lissencephaly (HP:0001339)1.64533651
189Metabolic acidosis (HP:0001942)1.63998674
190Decreased circulating renin level (HP:0003351)1.63049191
191Gastrointestinal atresia (HP:0002589)1.61410302
192Metabolic alkalosis (HP:0200114)1.60968322
193Pallor (HP:0000980)1.60723842

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB36.14003863
2MAPKAPK55.19366551
3NME14.91948523
4MKNK14.28260487
5KSR23.60834803
6TRPM73.40366393
7EPHA42.89795398
8BMPR1B2.76847957
9RAF12.76762345
10DMPK2.61698372
11PBK2.56218501
12KSR12.50395356
13TLK12.43787565
14PNCK2.41033967
15PLK42.36444758
16IRAK22.30421108
17RPS6KB22.18455935
18VRK22.16279050
19BMPR22.16060882
20CDC72.14479914
21ZAK1.95854776
22TAF11.93740707
23PAK61.87842993
24TSSK61.83002470
25NTRK31.80078782
26PAK31.77988220
27INSRR1.76209676
28NEK21.68487490
29TEC1.67446122
30WNK31.65229703
31WEE11.64977914
32STK161.60107853
33BRSK21.58663071
34PLK31.58629305
35OXSR11.57231723
36FRK1.54022321
37RPS6KA51.52529714
38CDK31.50671087
39MKNK21.44657425
40STK391.42158280
41DYRK21.41688683
42MAP2K11.40982441
43IRAK11.33683464
44VRK11.30392651
45WNK41.29694536
46BLK1.27475813
47PHKG21.25771593
48PHKG11.25771593
49PINK11.24221826
50ACVR1B1.18616111
51PLK11.14594242
52CAMK2A1.07432351
53MAP3K21.01403320
54NLK1.00805410
55TTK0.95886164
56PRKCQ0.95058447
57MAP3K90.94402302
58CAMK2B0.92049867
59BCR0.91661422
60ARAF0.91128618
61CHEK20.89685238
62NTRK20.88092775
63RPS6KA20.87126242
64MAPK130.86357355
65PIK3CG0.86185740
66CSNK1A1L0.83709038
67DYRK30.82540028
68MAPK150.81614851
69SRPK10.81399901
70MAPKAPK20.79597848
71STK240.76497607
72CAMK2G0.76280181
73MAP3K100.74963399
74CAMK2D0.72859585
75BTK0.72706450
76TRIM280.71491427
77CSNK1G30.71089501
78ITK0.67623768
79AURKB0.63518473
80CDK80.63085298
81WNK10.62971362
82PRKCE0.62943441
83BRSK10.62110222
84CDK190.59374782
85HCK0.59254413
86MAP2K20.54889582
87CAMK10.53706143
88CSNK1E0.53201865
89TNIK0.52292183
90CASK0.52160881
91CSNK1G20.48828543
92RIPK40.47497639
93MAP3K120.47474055
94MATK0.47471435
95TAOK10.47378392
96CSNK1G10.46922171
97MAPK40.46364349
98CSNK2A10.45934988
99MAP3K40.43636667
100MINK10.43505545
101PRKCD0.43439581
102PIM20.43335056
103MET0.42535879
104PRKD20.41772640
105BCKDK0.40983934
106PRKACA0.40825170
107FGFR10.40694191
108PIK3CA0.39537541
109CSNK1A10.39312103
110FGFR20.39057402
111PASK0.38470751
112PRKCG0.37889303
113PRKACG0.37137227
114ADRBK20.37113633
115PRKAA20.36353808
116BRAF0.36328866
117SGK20.36234402
118CSNK2A20.36086304
119CDK70.35148403
120FER0.34396293
121GRK10.34296977
122ADRBK10.32454774
123PTK20.32383593
124CHEK10.32332324
125ROCK10.32327512
126CSF1R0.32250841
127MST40.30025115
128PKN10.30023840
129PRKACB0.29957000
130CDK10.29945199
131SYK0.29850558
132ATR0.29594973
133AKT30.29582569
134PRKCA0.28704740
135IRAK40.28701687
136RPS6KC10.28390407
137RPS6KL10.28390407
138SGK2230.27866098
139SGK4940.27866098
140ATM0.27855673
141CDC42BPA0.27841919
142PRKCI0.27149718
143TYK20.27121082
144PDK30.26323974
145PDK40.26323974
146RPS6KA10.24984645
147STK40.24859302
148FLT30.24650025
149MAP2K70.24136793
150PRKDC0.24004695
151MAPK70.23279798
152CDK20.22799326
153MARK10.22766653
154EPHB20.22581164
155ALK0.22508570
156NUAK10.22256105
157PRKCZ0.21557461
158MAP3K10.20822275
159PDPK10.19111178
160BUB10.19037258
161TESK10.18557332
162CDK90.17767939
163PLK20.17464681
164RPS6KA60.17298708
165PTK2B0.17093048
166UHMK10.17067783
167PRKG10.16533426
168IGF1R0.16265580

Predicted pathways (KEGG)

RankGene SetZ-score
1Taste transduction_Homo sapiens_hsa047424.15588255
2Linoleic acid metabolism_Homo sapiens_hsa005914.04676612
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.95677924
4Ribosome_Homo sapiens_hsa030103.86172836
5Carbohydrate digestion and absorption_Homo sapiens_hsa049733.82990142
6Arachidonic acid metabolism_Homo sapiens_hsa005903.73002529
7RNA polymerase_Homo sapiens_hsa030203.49786731
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.09293761
9Choline metabolism in cancer_Homo sapiens_hsa052312.81198066
10Ether lipid metabolism_Homo sapiens_hsa005652.56419961
11Huntingtons disease_Homo sapiens_hsa050162.48019404
12Vitamin digestion and absorption_Homo sapiens_hsa049772.43600551
13Serotonergic synapse_Homo sapiens_hsa047262.42524478
14Homologous recombination_Homo sapiens_hsa034402.38357924
15Proteasome_Homo sapiens_hsa030502.31114025
16Selenocompound metabolism_Homo sapiens_hsa004502.28108472
17Long-term depression_Homo sapiens_hsa047302.13499543
18Glycerolipid metabolism_Homo sapiens_hsa005612.10172730
19Glycerophospholipid metabolism_Homo sapiens_hsa005642.03132017
20Protein export_Homo sapiens_hsa030601.98236956
21Basal transcription factors_Homo sapiens_hsa030221.88327650
22Sulfur relay system_Homo sapiens_hsa041221.87738863
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.87248850
24Phospholipase D signaling pathway_Homo sapiens_hsa040721.83772680
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.74177004
26Base excision repair_Homo sapiens_hsa034101.73189999
27Dorso-ventral axis formation_Homo sapiens_hsa043201.64974649
28Ovarian steroidogenesis_Homo sapiens_hsa049131.64469827
29DNA replication_Homo sapiens_hsa030301.64177587
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62427963
31RNA degradation_Homo sapiens_hsa030181.58954616
32Mismatch repair_Homo sapiens_hsa034301.54955414
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.50027373
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49615362
35Fat digestion and absorption_Homo sapiens_hsa049751.48059819
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46924155
37RNA transport_Homo sapiens_hsa030131.33734634
38Mineral absorption_Homo sapiens_hsa049781.31387624
39Caffeine metabolism_Homo sapiens_hsa002321.30218715
40Type II diabetes mellitus_Homo sapiens_hsa049301.28724195
41Vascular smooth muscle contraction_Homo sapiens_hsa042701.24868586
42Spliceosome_Homo sapiens_hsa030401.23872036
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.23841921
44Nucleotide excision repair_Homo sapiens_hsa034201.18668584
45Sulfur metabolism_Homo sapiens_hsa009201.17797810
46Glutamatergic synapse_Homo sapiens_hsa047241.15293110
47GnRH signaling pathway_Homo sapiens_hsa049121.14855296
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14711687
49Purine metabolism_Homo sapiens_hsa002301.14349028
50Vibrio cholerae infection_Homo sapiens_hsa051101.12837389
51Folate biosynthesis_Homo sapiens_hsa007901.12696235
52Tryptophan metabolism_Homo sapiens_hsa003801.11402007
53Fanconi anemia pathway_Homo sapiens_hsa034601.10574031
54VEGF signaling pathway_Homo sapiens_hsa043701.08748024
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07825724
56Pyrimidine metabolism_Homo sapiens_hsa002401.07266105
57One carbon pool by folate_Homo sapiens_hsa006701.06766708
58Insulin secretion_Homo sapiens_hsa049111.06423411
59Fatty acid degradation_Homo sapiens_hsa000711.06105718
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03715946
61PPAR signaling pathway_Homo sapiens_hsa033201.01258149
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00441079
63Alzheimers disease_Homo sapiens_hsa050100.96688483
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96085460
65Pancreatic secretion_Homo sapiens_hsa049720.94489210
66Basal cell carcinoma_Homo sapiens_hsa052170.94394156
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92161970
68Nicotine addiction_Homo sapiens_hsa050330.90749855
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90277810
70Platelet activation_Homo sapiens_hsa046110.89553776
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88935465
72Cocaine addiction_Homo sapiens_hsa050300.88733606
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86872733
74Cell cycle_Homo sapiens_hsa041100.85994794
75Butanoate metabolism_Homo sapiens_hsa006500.85684584
76mRNA surveillance pathway_Homo sapiens_hsa030150.84531083
77Retinol metabolism_Homo sapiens_hsa008300.84374450
78Phototransduction_Homo sapiens_hsa047440.84220516
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.83347112
80Long-term potentiation_Homo sapiens_hsa047200.83255239
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82428322
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81710292
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81391015
84GABAergic synapse_Homo sapiens_hsa047270.80875601
85Fructose and mannose metabolism_Homo sapiens_hsa000510.80548884
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78870360
87Oxidative phosphorylation_Homo sapiens_hsa001900.75204945
88Vitamin B6 metabolism_Homo sapiens_hsa007500.74492917
89Pyruvate metabolism_Homo sapiens_hsa006200.73792690
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73421492
91Metabolic pathways_Homo sapiens_hsa011000.72010553
92Nitrogen metabolism_Homo sapiens_hsa009100.71581236
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70931208
94Morphine addiction_Homo sapiens_hsa050320.70802736
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.70081099
96Gap junction_Homo sapiens_hsa045400.67898714
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67551926
98Chemical carcinogenesis_Homo sapiens_hsa052040.66664824
99Renal cell carcinoma_Homo sapiens_hsa052110.66092506
100Oxytocin signaling pathway_Homo sapiens_hsa049210.65939659
101Synaptic vesicle cycle_Homo sapiens_hsa047210.65904880
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65466984
103Peroxisome_Homo sapiens_hsa041460.65101718
104Circadian entrainment_Homo sapiens_hsa047130.64911989
105MAPK signaling pathway_Homo sapiens_hsa040100.63972554
106Collecting duct acid secretion_Homo sapiens_hsa049660.62789442
107Propanoate metabolism_Homo sapiens_hsa006400.60975505
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60896841
109Olfactory transduction_Homo sapiens_hsa047400.59608909
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.59307872
111Cholinergic synapse_Homo sapiens_hsa047250.59207963
112Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59103966
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58794886
114Hedgehog signaling pathway_Homo sapiens_hsa043400.58551813
115Dopaminergic synapse_Homo sapiens_hsa047280.57991754
116Tyrosine metabolism_Homo sapiens_hsa003500.57270107
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56978818
118ErbB signaling pathway_Homo sapiens_hsa040120.56934631
119Maturity onset diabetes of the young_Homo sapiens_hsa049500.56474913
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56049110
121Ras signaling pathway_Homo sapiens_hsa040140.55698825
122Galactose metabolism_Homo sapiens_hsa000520.55637733
123Renin secretion_Homo sapiens_hsa049240.54039791
124Amphetamine addiction_Homo sapiens_hsa050310.53928066
125Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53434457
126Estrogen signaling pathway_Homo sapiens_hsa049150.53099670
127Gastric acid secretion_Homo sapiens_hsa049710.52876261
128Steroid biosynthesis_Homo sapiens_hsa001000.51912562
129cAMP signaling pathway_Homo sapiens_hsa040240.51669210
130B cell receptor signaling pathway_Homo sapiens_hsa046620.51054253
131Toxoplasmosis_Homo sapiens_hsa051450.50959430
132Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50543316
133Oocyte meiosis_Homo sapiens_hsa041140.50112516
134Bile secretion_Homo sapiens_hsa049760.50082529
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49501359
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48073398
137Melanogenesis_Homo sapiens_hsa049160.47173995
138Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46031925
139Wnt signaling pathway_Homo sapiens_hsa043100.45660920
140Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44834895
141Hippo signaling pathway_Homo sapiens_hsa043900.44068341
142Renin-angiotensin system_Homo sapiens_hsa046140.42873617
143Cardiac muscle contraction_Homo sapiens_hsa042600.42364853
144Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41179611
145Parkinsons disease_Homo sapiens_hsa050120.40925338
146Melanoma_Homo sapiens_hsa052180.40294026
147Non-homologous end-joining_Homo sapiens_hsa034500.39577369
148Endometrial cancer_Homo sapiens_hsa052130.39422969
149Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38693571
150Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38409303
151Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37865716
152Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37628729
153Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37509953
154Salivary secretion_Homo sapiens_hsa049700.37205565
155Tight junction_Homo sapiens_hsa045300.37191007
156Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37030930
157Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36771185
158Protein digestion and absorption_Homo sapiens_hsa049740.36546952
159Inositol phosphate metabolism_Homo sapiens_hsa005620.35955139
160Colorectal cancer_Homo sapiens_hsa052100.34884805
161Axon guidance_Homo sapiens_hsa043600.34374646
162Insulin signaling pathway_Homo sapiens_hsa049100.33984139
163Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33979139
164Histidine metabolism_Homo sapiens_hsa003400.33340725
165Acute myeloid leukemia_Homo sapiens_hsa052210.32264748
166Glioma_Homo sapiens_hsa052140.31866295
167Bladder cancer_Homo sapiens_hsa052190.31594239
168Pancreatic cancer_Homo sapiens_hsa052120.30420022
169Sphingolipid signaling pathway_Homo sapiens_hsa040710.30302912
170Non-small cell lung cancer_Homo sapiens_hsa052230.30042699

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