

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | actin-myosin filament sliding (GO:0033275) | 9.89928775 |
| 2 | muscle filament sliding (GO:0030049) | 9.89928775 |
| 3 | sarcomere organization (GO:0045214) | 8.96419918 |
| 4 | cardiac myofibril assembly (GO:0055003) | 8.36936343 |
| 5 | actin-mediated cell contraction (GO:0070252) | 8.33158487 |
| 6 | myofibril assembly (GO:0030239) | 8.14637395 |
| 7 | regulation of skeletal muscle contraction (GO:0014819) | 7.56396937 |
| 8 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 7.21516007 |
| 9 | cardiac muscle contraction (GO:0060048) | 6.79852377 |
| 10 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 6.61208930 |
| 11 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 6.39149349 |
| 12 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 6.38173785 |
| 13 | striated muscle contraction (GO:0006941) | 6.29258572 |
| 14 | cardiac muscle cell development (GO:0055013) | 6.28761247 |
| 15 | actin filament-based movement (GO:0030048) | 6.19315545 |
| 16 | cardiac muscle tissue morphogenesis (GO:0055008) | 6.12381414 |
| 17 | actomyosin structure organization (GO:0031032) | 6.10347046 |
| 18 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 6.05824550 |
| 19 | heart process (GO:0003015) | 5.93804436 |
| 20 | heart contraction (GO:0060047) | 5.93804436 |
| 21 | cardiac cell development (GO:0055006) | 5.91240228 |
| 22 | plasma membrane repair (GO:0001778) | 5.77631669 |
| 23 | regulation of relaxation of muscle (GO:1901077) | 5.75118509 |
| 24 | skeletal muscle fiber development (GO:0048741) | 5.65118788 |
| 25 | muscle tissue morphogenesis (GO:0060415) | 5.60312144 |
| 26 | regulation of actin filament-based movement (GO:1903115) | 5.56922470 |
| 27 | cardiac muscle hypertrophy (GO:0003300) | 5.52576944 |
| 28 | adult heart development (GO:0007512) | 5.47369462 |
| 29 | ventricular cardiac muscle tissue morphogenesis (GO:0055010) | 5.40226408 |
| 30 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 5.39988234 |
| 31 | tricarboxylic acid cycle (GO:0006099) | 5.36489953 |
| 32 | striated muscle hypertrophy (GO:0014897) | 5.34357530 |
| 33 | skeletal muscle contraction (GO:0003009) | 5.30121282 |
| 34 | regulation of cell communication by electrical coupling (GO:0010649) | 5.27257539 |
| 35 | regulation of sarcomere organization (GO:0060297) | 5.27089201 |
| 36 | myotube cell development (GO:0014904) | 5.24414127 |
| 37 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 5.23860419 |
| 38 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 5.23472494 |
| 39 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 5.15019475 |
| 40 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.00084740 |
| 41 | regulation of striated muscle contraction (GO:0006942) | 4.94089028 |
| 42 | negative regulation of cardiac muscle cell apoptotic process (GO:0010667) | 4.83170405 |
| 43 | ventricular cardiac muscle cell action potential (GO:0086005) | 4.79500079 |
| 44 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.79073149 |
| 45 | ATP synthesis coupled proton transport (GO:0015986) | 4.79073149 |
| 46 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 4.78452388 |
| 47 | carnitine shuttle (GO:0006853) | 4.76680627 |
| 48 | glucan catabolic process (GO:0009251) | 4.73162105 |
| 49 | muscle hypertrophy (GO:0014896) | 4.72465503 |
| 50 | NADH metabolic process (GO:0006734) | 4.72403229 |
| 51 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 4.72309953 |
| 52 | heart trabecula formation (GO:0060347) | 4.70484461 |
| 53 | glycogen biosynthetic process (GO:0005978) | 4.60711138 |
| 54 | glucan biosynthetic process (GO:0009250) | 4.60711138 |
| 55 | regulation of the force of heart contraction (GO:0002026) | 4.47794100 |
| 56 | cellular polysaccharide catabolic process (GO:0044247) | 4.42346825 |
| 57 | regulation of membrane repolarization (GO:0060306) | 4.38671225 |
| 58 | negative regulation of protein localization to cell surface (GO:2000009) | 4.36910311 |
| 59 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 4.33998261 |
| 60 | negative regulation of striated muscle cell apoptotic process (GO:0010664) | 4.32144356 |
| 61 | muscle contraction (GO:0006936) | 4.25797282 |
| 62 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.20490791 |
| 63 | skeletal muscle adaptation (GO:0043501) | 4.19536663 |
| 64 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 4.16046317 |
| 65 | respiratory electron transport chain (GO:0022904) | 4.14530276 |
| 66 | skeletal muscle tissue development (GO:0007519) | 4.13956332 |
| 67 | oxidative phosphorylation (GO:0006119) | 4.08392955 |
| 68 | cardiac muscle hypertrophy in response to stress (GO:0014898) | 4.07743471 |
| 69 | muscle hypertrophy in response to stress (GO:0003299) | 4.07743471 |
| 70 | cardiac muscle adaptation (GO:0014887) | 4.07743471 |
| 71 | muscle cell cellular homeostasis (GO:0046716) | 4.06468046 |
| 72 | striated muscle cell development (GO:0055002) | 4.06387248 |
| 73 | response to inactivity (GO:0014854) | 4.05456912 |
| 74 | electron transport chain (GO:0022900) | 4.02668364 |
| 75 | regulation of cardioblast differentiation (GO:0051890) | 3.98206819 |
| 76 | regulation of coenzyme metabolic process (GO:0051196) | 3.98067459 |
| 77 | regulation of cofactor metabolic process (GO:0051193) | 3.98067459 |
| 78 | polysaccharide catabolic process (GO:0000272) | 3.97170566 |
| 79 | muscle cell fate commitment (GO:0042693) | 3.96674341 |
| 80 | fatty acid transmembrane transport (GO:1902001) | 3.95525405 |
| 81 | striated muscle adaptation (GO:0014888) | 3.94444201 |
| 82 | muscle system process (GO:0003012) | 3.93262748 |
| 83 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.88500798 |
| 84 | 2-oxoglutarate metabolic process (GO:0006103) | 3.84025260 |
| 85 | skeletal muscle tissue regeneration (GO:0043403) | 3.83974200 |
| 86 | gluconeogenesis (GO:0006094) | 3.82608162 |
| 87 | negative regulation of calcium ion transmembrane transport (GO:1903170) | 3.82252865 |
| 88 | negative regulation of calcium ion transmembrane transporter activity (GO:1901020) | 3.82252865 |
| 89 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 3.72560229 |
| 90 | regulation of ATP catabolic process (GO:1903289) | 3.69383239 |
| 91 | regulation of ATPase activity (GO:0043462) | 3.69383239 |
| 92 | cytidine deamination (GO:0009972) | 3.65474859 |
| 93 | cytidine metabolic process (GO:0046087) | 3.65474859 |
| 94 | cytidine catabolic process (GO:0006216) | 3.65474859 |
| 95 | regulation of muscle contraction (GO:0006937) | 3.64819161 |
| 96 | cardiac muscle cell action potential (GO:0086001) | 3.64255631 |
| 97 | regulation of calcium ion transmembrane transport (GO:1903169) | 3.63678386 |
| 98 | regulation of calcium ion transmembrane transporter activity (GO:1901019) | 3.63678386 |
| 99 | cardiac muscle cell action potential involved in contraction (GO:0086002) | 3.63580354 |
| 100 | fructose metabolic process (GO:0006000) | 3.63121031 |
| 101 | muscle fiber development (GO:0048747) | 3.60866168 |
| 102 | regulation of heart rate (GO:0002027) | 3.60357364 |
| 103 | glycogen metabolic process (GO:0005977) | 3.59700649 |
| 104 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 3.57640988 |
| 105 | cell communication involved in cardiac conduction (GO:0086065) | 3.55282700 |
| 106 | muscle structure development (GO:0061061) | 3.52237311 |
| 107 | muscle organ development (GO:0007517) | 3.52213643 |
| 108 | regulation of cardiac muscle contraction (GO:0055117) | 3.52058149 |
| 109 | cellular glucan metabolic process (GO:0006073) | 3.51288301 |
| 110 | glucan metabolic process (GO:0044042) | 3.51288301 |
| 111 | positive regulation of myotube differentiation (GO:0010831) | 3.50948215 |
| 112 | negative regulation of potassium ion transport (GO:0043267) | 3.48759208 |
| 113 | negative regulation of muscle hypertrophy (GO:0014741) | 3.48278159 |
| 114 | creatine metabolic process (GO:0006600) | 3.48076680 |
| 115 | muscle cell development (GO:0055001) | 3.46823080 |
| 116 | regulation of striated muscle cell apoptotic process (GO:0010662) | 3.46033138 |
| 117 | glycogen catabolic process (GO:0005980) | 3.42440614 |
| 118 | neuronal action potential propagation (GO:0019227) | 3.42252563 |
| 119 | carnitine transmembrane transport (GO:1902603) | 3.41963900 |
| 120 | relaxation of muscle (GO:0090075) | 3.40987966 |
| 121 | hexose biosynthetic process (GO:0019319) | 3.39764063 |
| 122 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 3.37036359 |
| 123 | muscle organ morphogenesis (GO:0048644) | 3.36849727 |
| 124 | positive regulation of mitochondrial calcium ion concentration (GO:0051561) | 3.36177758 |
| 125 | ventricular cardiac muscle cell development (GO:0055015) | 3.35462953 |
| 126 | regulation of muscle system process (GO:0090257) | 3.33810923 |
| 127 | cell communication by electrical coupling (GO:0010644) | 3.33314338 |
| 128 | IMP metabolic process (GO:0046040) | 3.32680937 |
| 129 | response to activity (GO:0014823) | 3.30696824 |
| 130 | response to muscle activity (GO:0014850) | 3.30388750 |
| 131 | muscle adaptation (GO:0043500) | 3.30320397 |
| 132 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.29700456 |
| 133 | regulation of heart contraction (GO:0008016) | 3.29176604 |
| 134 | striated muscle atrophy (GO:0014891) | 3.28915321 |
| 135 | cardiac chamber formation (GO:0003207) | 3.28877913 |
| 136 | ubiquinone biosynthetic process (GO:0006744) | 3.28443629 |
| 137 | succinate metabolic process (GO:0006105) | 3.26990857 |
| 138 | oxaloacetate metabolic process (GO:0006107) | 3.21466118 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 5.37276870 |
| 2 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 5.07600660 |
| 3 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 4.84857097 |
| 4 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 4.16780281 |
| 5 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 3.68782700 |
| 6 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 3.46594493 |
| 7 | * TBX20_22328084_ChIP-Seq_HEART_Mouse | 3.44387833 |
| 8 | * TBX20_22080862_ChIP-Seq_HEART_Mouse | 3.44387833 |
| 9 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.39146047 |
| 10 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 3.35058504 |
| 11 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 3.30131673 |
| 12 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.90867657 |
| 13 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.61346776 |
| 14 | * CDX2_19796622_ChIP-Seq_MESCs_Mouse | 2.46028183 |
| 15 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.32420047 |
| 16 | * GATA4_21415370_ChIP-Seq_HL-1_Mouse | 2.27271266 |
| 17 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 2.21137370 |
| 18 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.85380816 |
| 19 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.78964714 |
| 20 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.76965322 |
| 21 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.76483196 |
| 22 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 1.64251341 |
| 23 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 1.63876266 |
| 24 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.60331258 |
| 25 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.58743518 |
| 26 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 1.58264235 |
| 27 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.51517493 |
| 28 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.51517493 |
| 29 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.50382330 |
| 30 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.47013528 |
| 31 | VDR_22108803_ChIP-Seq_LS180_Human | 1.44928494 |
| 32 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.44800578 |
| 33 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 1.41951765 |
| 34 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.40019515 |
| 35 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.38172650 |
| 36 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.36931219 |
| 37 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.29980026 |
| 38 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 1.29211137 |
| 39 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 1.28927772 |
| 40 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.28181293 |
| 41 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.27533455 |
| 42 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.26637916 |
| 43 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.25258415 |
| 44 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.24875448 |
| 45 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.24332565 |
| 46 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.23081390 |
| 47 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.22928177 |
| 48 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.22219328 |
| 49 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.20160530 |
| 50 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.19607514 |
| 51 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.15697043 |
| 52 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.15555002 |
| 53 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.15072496 |
| 54 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.14868675 |
| 55 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.12641701 |
| 56 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 1.11121846 |
| 57 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.11061495 |
| 58 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.10592706 |
| 59 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.09744744 |
| 60 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.09500974 |
| 61 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 1.09471558 |
| 62 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.08448216 |
| 63 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.07068339 |
| 64 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.06820175 |
| 65 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.06800110 |
| 66 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.06077972 |
| 67 | PHF8_20622853_ChIP-Seq_HELA_Human | 1.05239219 |
| 68 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.04940421 |
| 69 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.04585997 |
| 70 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.03912551 |
| 71 | FUS_26573619_Chip-Seq_HEK293_Human | 1.03286846 |
| 72 | CJUN_26792858_Chip-Seq_BT549_Human | 1.02168855 |
| 73 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.02084076 |
| 74 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.02055668 |
| 75 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.00436706 |
| 76 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.99808061 |
| 77 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 0.99667880 |
| 78 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 0.99260807 |
| 79 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 0.98221631 |
| 80 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 0.98057915 |
| 81 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 0.96915530 |
| 82 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.96325047 |
| 83 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.96093070 |
| 84 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.95690933 |
| 85 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 0.95606462 |
| 86 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.95436831 |
| 87 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.95364525 |
| 88 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.95364525 |
| 89 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 0.93104557 |
| 90 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.92799641 |
| 91 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.92440583 |
| 92 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.90972790 |
| 93 | NFYB_21822215_ChIP-Seq_K562_Human | 0.90421261 |
| 94 | AR_21572438_ChIP-Seq_LNCaP_Human | 0.90059619 |
| 95 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 0.89695568 |
| 96 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.89641107 |
| 97 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.89503365 |
| 98 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 0.89242095 |
| 99 | * SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 0.89108902 |
| 100 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 0.86743869 |
| 101 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.86676126 |
| 102 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.86628673 |
| 103 | SMC3_22415368_ChIP-Seq_MEFs_Mouse | 0.86336243 |
| 104 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.85738448 |
| 105 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.84356933 |
| 106 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.84144403 |
| 107 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.84144403 |
| 108 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 0.83850395 |
| 109 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 0.83848083 |
| 110 | SMAD4_21799915_ChIP-Seq_A2780_Human | 0.83621661 |
| 111 | STAT3_19079543_ChIP-ChIP_MESCs_Mouse | 0.82834004 |
| 112 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.81185588 |
| 113 | CBP_21632823_ChIP-Seq_H3396_Human | 0.81129414 |
| 114 | CBX2_22325352_ChIP-Seq_293T-Rex_Human | 0.80417483 |
| 115 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 0.80234063 |
| 116 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.80166707 |
| 117 | HNFA_21074721_ChIP-Seq_CACO-2_Human | 0.79989274 |
| 118 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 0.79700515 |
| 119 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.79449648 |
| 120 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.79339513 |
| 121 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.78902287 |
| 122 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.78503070 |
| 123 | * TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.78098514 |
| 124 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 0.77219009 |
| 125 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.76725330 |
| 126 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 0.76251695 |
| 127 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.76019084 |
| 128 | PCGF4_22325352_ChIP-Seq_293T-Rex_Human | 0.75833362 |
| 129 | PRDM14_21183938_ChIP-Seq_MESCs_Mouse | 0.75786352 |
| 130 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.75043564 |
| 131 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.73804777 |
| 132 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.73804777 |
| 133 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.73506356 |
| 134 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.73378335 |
| 135 | CLOCK_20551151_ChIP-Seq_293T_Human | 0.72859608 |
| 136 | MYC_27129775_Chip-Seq_CORNEA_Mouse | 0.71937536 |
| 137 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.71920797 |
| 138 | ETV1_20927104_ChIP-Seq_GIST48_Human | 0.71841482 |
| 139 | TBL1_22424771_ChIP-Seq_293T_Human | 0.71113910 |
| 140 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.71026156 |
| 141 | * AR_19668381_ChIP-Seq_PC3_Human | 0.70991422 |
| 142 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.70855371 |
| 143 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.68614461 |
| 144 | GBX2_23144817_ChIP-Seq_PC3_Human | 0.68507415 |
| 145 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.67761205 |
| 146 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.67662149 |
| 147 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 0.67328389 |
| 148 | TP63_22573176_ChIP-Seq_HFKS_Human | 0.67243004 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002837_dystrophic_cardiac_calcinosis | 5.66190071 |
| 2 | MP0004084_abnormal_cardiac_muscle | 5.40353399 |
| 3 | MP0003646_muscle_fatigue | 5.34259178 |
| 4 | MP0000749_muscle_degeneration | 5.18237608 |
| 5 | MP0000751_myopathy | 5.15599666 |
| 6 | MP0004036_abnormal_muscle_relaxation | 4.78436512 |
| 7 | MP0004145_abnormal_muscle_electrophysio | 4.50858925 |
| 8 | MP0004215_abnormal_myocardial_fiber | 4.02946331 |
| 9 | MP0005330_cardiomyopathy | 3.70041169 |
| 10 | MP0004087_abnormal_muscle_fiber | 3.32561329 |
| 11 | MP0005620_abnormal_muscle_contractility | 3.21756712 |
| 12 | MP0002106_abnormal_muscle_physiology | 3.16306030 |
| 13 | MP0002972_abnormal_cardiac_muscle | 3.12653386 |
| 14 | MP0000750_abnormal_muscle_regeneration | 2.74573734 |
| 15 | MP0003137_abnormal_impulse_conducting | 2.67645468 |
| 16 | MP0002269_muscular_atrophy | 2.67323052 |
| 17 | MP0008775_abnormal_heart_ventricle | 2.63421047 |
| 18 | MP0000747_muscle_weakness | 2.62054771 |
| 19 | MP0005369_muscle_phenotype | 2.58348841 |
| 20 | MP0000759_abnormal_skeletal_muscle | 2.49498835 |
| 21 | MP0010630_abnormal_cardiac_muscle | 2.43649719 |
| 22 | MP0001544_abnormal_cardiovascular_syste | 2.33963653 |
| 23 | MP0005385_cardiovascular_system_phenoty | 2.33963653 |
| 24 | MP0004484_altered_response_of | 2.24175757 |
| 25 | MP0004130_abnormal_muscle_cell | 2.22244741 |
| 26 | MP0006138_congestive_heart_failure | 2.12462738 |
| 27 | MP0004233_abnormal_muscle_weight | 2.10773504 |
| 28 | MP0003828_pulmonary_edema | 2.02990557 |
| 29 | MP0003221_abnormal_cardiomyocyte_apopto | 1.99556652 |
| 30 | MP0004085_abnormal_heartbeat | 1.94753439 |
| 31 | MP0003950_abnormal_plasma_membrane | 1.90378095 |
| 32 | MP0006036_abnormal_mitochondrial_physio | 1.79428865 |
| 33 | MP0002127_abnormal_cardiovascular_syste | 1.78803360 |
| 34 | MP0004510_myositis | 1.72223660 |
| 35 | MP0002332_abnormal_exercise_endurance | 1.67801036 |
| 36 | MP0003567_abnormal_fetal_cardiomyocyte | 1.43844480 |
| 37 | MP0004270_analgesia | 1.43150522 |
| 38 | MP0005451_abnormal_body_composition | 1.20093416 |
| 39 | MP0000266_abnormal_heart_morphology | 1.09875396 |
| 40 | MP0002108_abnormal_muscle_morphology | 1.08447689 |
| 41 | MP0006035_abnormal_mitochondrial_morpho | 1.08070329 |
| 42 | MP0001661_extended_life_span | 1.06276881 |
| 43 | MP0002234_abnormal_pharynx_morphology | 1.03004706 |
| 44 | MP0005666_abnormal_adipose_tissue | 0.97962519 |
| 45 | MP0000733_abnormal_muscle_development | 0.97391911 |
| 46 | MP0009780_abnormal_chondrocyte_physiolo | 0.89816013 |
| 47 | MP0002822_catalepsy | 0.87372792 |
| 48 | MP0000343_altered_response_to | 0.82732096 |
| 49 | MP0000372_irregular_coat_pigmentation | 0.81528624 |
| 50 | MP0003279_aneurysm | 0.80651899 |
| 51 | MP0005266_abnormal_metabolism | 0.76386379 |
| 52 | MP0005670_abnormal_white_adipose | 0.75276845 |
| 53 | MP0000230_abnormal_systemic_arterial | 0.74258496 |
| 54 | MP0003122_maternal_imprinting | 0.73734687 |
| 55 | MP0005165_increased_susceptibility_to | 0.69866715 |
| 56 | MP0004147_increased_porphyrin_level | 0.67147359 |
| 57 | MP0002128_abnormal_blood_circulation | 0.65968805 |
| 58 | MP0004185_abnormal_adipocyte_glucose | 0.65432499 |
| 59 | MP0010368_abnormal_lymphatic_system | 0.64686293 |
| 60 | MP0005375_adipose_tissue_phenotype | 0.60367945 |
| 61 | MP0004272_abnormal_basement_membrane | 0.60306924 |
| 62 | MP0004043_abnormal_pH_regulation | 0.58617397 |
| 63 | MP0001879_abnormal_lymphatic_vessel | 0.57100492 |
| 64 | MP0010030_abnormal_orbit_morphology | 0.56660866 |
| 65 | MP0009384_cardiac_valve_regurgitation | 0.55619692 |
| 66 | MP0003806_abnormal_nucleotide_metabolis | 0.55450782 |
| 67 | MP0005623_abnormal_meninges_morphology | 0.53850663 |
| 68 | MP0002971_abnormal_brown_adipose | 0.51978051 |
| 69 | MP0000767_abnormal_smooth_muscle | 0.47856727 |
| 70 | MP0003566_abnormal_cell_adhesion | 0.47557953 |
| 71 | MP0003385_abnormal_body_wall | 0.47466730 |
| 72 | MP0000013_abnormal_adipose_tissue | 0.46824391 |
| 73 | MP0002925_abnormal_cardiovascular_devel | 0.46490106 |
| 74 | MP0001984_abnormal_olfaction | 0.45149049 |
| 75 | MP0000762_abnormal_tongue_morphology | 0.43432230 |
| 76 | MP0005423_abnormal_somatic_nervous | 0.43197118 |
| 77 | MP0005377_hearing/vestibular/ear_phenot | 0.43173151 |
| 78 | MP0003878_abnormal_ear_physiology | 0.43173151 |
| 79 | MP0002734_abnormal_mechanical_nocicepti | 0.42469983 |
| 80 | MP0003948_abnormal_gas_homeostasis | 0.41092860 |
| 81 | MP0005332_abnormal_amino_acid | 0.40578047 |
| 82 | MP0001784_abnormal_fluid_regulation | 0.39550168 |
| 83 | MP0003656_abnormal_erythrocyte_physiolo | 0.39421710 |
| 84 | MP0009672_abnormal_birth_weight | 0.38632554 |
| 85 | MP0009250_abnormal_appendicular_skeleto | 0.37894621 |
| 86 | MP0001727_abnormal_embryo_implantation | 0.37457623 |
| 87 | MP0003879_abnormal_hair_cell | 0.37312211 |
| 88 | MP0006276_abnormal_autonomic_nervous | 0.36010742 |
| 89 | MP0002114_abnormal_axial_skeleton | 0.34873699 |
| 90 | MP0001529_abnormal_vocalization | 0.33981695 |
| 91 | MP0001346_abnormal_lacrimal_gland | 0.33022767 |
| 92 | MP0005595_abnormal_vascular_smooth | 0.31878199 |
| 93 | MP0001614_abnormal_blood_vessel | 0.31670958 |
| 94 | MP0002088_abnormal_embryonic_growth/wei | 0.31145745 |
| 95 | MP0003984_embryonic_growth_retardation | 0.30911739 |
| 96 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.30892439 |
| 97 | MP0002066_abnormal_motor_capabilities/c | 0.30601853 |
| 98 | MP0003011_delayed_dark_adaptation | 0.30229098 |
| 99 | MP0003045_fibrosis | 0.30068337 |
| 100 | MP0005503_abnormal_tendon_morphology | 0.29974508 |
| 101 | MP0002078_abnormal_glucose_homeostasis | 0.29731274 |
| 102 | MP0005167_abnormal_blood-brain_barrier | 0.29715496 |
| 103 | MP0003941_abnormal_skin_development | 0.28369920 |
| 104 | MP0005334_abnormal_fat_pad | 0.26247241 |
| 105 | MP0002067_abnormal_sensory_capabilities | 0.25330490 |
| 106 | MP0005275_abnormal_skin_tensile | 0.25056781 |
| 107 | MP0000003_abnormal_adipose_tissue | 0.24755848 |
| 108 | MP0001485_abnormal_pinna_reflex | 0.23474102 |
| 109 | MP0003136_yellow_coat_color | 0.22784759 |
| 110 | MP0001943_abnormal_respiration | 0.22618506 |
| 111 | MP0005187_abnormal_penis_morphology | 0.22442284 |
| 112 | MP0005645_abnormal_hypothalamus_physiol | 0.22278133 |
| 113 | MP0002896_abnormal_bone_mineralization | 0.21256436 |
| 114 | MP0002272_abnormal_nervous_system | 0.20342622 |
| 115 | MP0005319_abnormal_enzyme/_coenzyme | 0.19798811 |
| 116 | MP0002909_abnormal_adrenal_gland | 0.19640488 |
| 117 | MP0004134_abnormal_chest_morphology | 0.19279869 |
| 118 | MP0002638_abnormal_pupillary_reflex | 0.18197089 |
| 119 | MP0001299_abnormal_eye_distance/ | 0.17495371 |
| 120 | MP0008961_abnormal_basal_metabolism | 0.17088930 |
| 121 | MP0005535_abnormal_body_temperature | 0.17039256 |
| 122 | MP0003705_abnormal_hypodermis_morpholog | 0.16728696 |
| 123 | MP0005452_abnormal_adipose_tissue | 0.16465656 |
| 124 | MP0002249_abnormal_larynx_morphology | 0.15711990 |
| 125 | MP0005388_respiratory_system_phenotype | 0.15181846 |
| 126 | MP0002133_abnormal_respiratory_system | 0.15181846 |
| 127 | MP0005376_homeostasis/metabolism_phenot | 0.15045361 |
| 128 | MP0008569_lethality_at_weaning | 0.14755450 |
| 129 | MP0004142_abnormal_muscle_tone | 0.14079032 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Exercise-induced muscle cramps (HP:0003710) | 7.79393733 |
| 2 | Exercise-induced myalgia (HP:0003738) | 7.63464082 |
| 3 | Sudden death (HP:0001699) | 7.20092954 |
| 4 | Calf muscle hypertrophy (HP:0008981) | 7.18521311 |
| 5 | Muscle hypertrophy of the lower extremities (HP:0008968) | 7.16072339 |
| 6 | Abnormality of the left ventricular outflow tract (HP:0011103) | 5.90069773 |
| 7 | Subaortic stenosis (HP:0001682) | 5.90069773 |
| 8 | Ventricular tachycardia (HP:0004756) | 5.69429191 |
| 9 | Abnormality of the calf musculature (HP:0001430) | 5.58127147 |
| 10 | Muscle fiber splitting (HP:0003555) | 5.40132140 |
| 11 | Muscle fiber inclusion bodies (HP:0100299) | 5.30203278 |
| 12 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 5.20919940 |
| 13 | Hyporeflexia of lower limbs (HP:0002600) | 5.15161179 |
| 14 | Myoglobinuria (HP:0002913) | 5.15032735 |
| 15 | Atrial fibrillation (HP:0005110) | 4.92362593 |
| 16 | Type 1 muscle fiber predominance (HP:0003803) | 4.85873253 |
| 17 | EMG: myopathic abnormalities (HP:0003458) | 4.82170480 |
| 18 | Nemaline bodies (HP:0003798) | 4.69031831 |
| 19 | Lipoatrophy (HP:0100578) | 4.67748679 |
| 20 | Primary atrial arrhythmia (HP:0001692) | 4.58052931 |
| 21 | Supraventricular tachycardia (HP:0004755) | 4.41338619 |
| 22 | Supraventricular arrhythmia (HP:0005115) | 4.31952691 |
| 23 | Rhabdomyolysis (HP:0003201) | 4.22567554 |
| 24 | Asymmetric septal hypertrophy (HP:0001670) | 4.02884995 |
| 25 | Difficulty running (HP:0009046) | 3.90916962 |
| 26 | Dilated cardiomyopathy (HP:0001644) | 3.83518429 |
| 27 | Myotonia (HP:0002486) | 3.79099644 |
| 28 | Right ventricular cardiomyopathy (HP:0011663) | 3.77588350 |
| 29 | Increased connective tissue (HP:0009025) | 3.76201208 |
| 30 | Prolonged QT interval (HP:0001657) | 3.73275487 |
| 31 | Syncope (HP:0001279) | 3.70887182 |
| 32 | Muscle stiffness (HP:0003552) | 3.68775248 |
| 33 | Ventricular arrhythmia (HP:0004308) | 3.58718954 |
| 34 | Palpitations (HP:0001962) | 3.58293809 |
| 35 | Distal arthrogryposis (HP:0005684) | 3.41295925 |
| 36 | Neck muscle weakness (HP:0000467) | 3.28127241 |
| 37 | Bundle branch block (HP:0011710) | 3.25954152 |
| 38 | Round ear (HP:0100830) | 3.05958873 |
| 39 | Malignant hyperthermia (HP:0002047) | 3.05142862 |
| 40 | Myopathic facies (HP:0002058) | 3.01390705 |
| 41 | Abnormal finger flexion creases (HP:0006143) | 2.98259774 |
| 42 | Acute necrotizing encephalopathy (HP:0006965) | 2.96727214 |
| 43 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.89567441 |
| 44 | Ventricular fibrillation (HP:0001663) | 2.89165855 |
| 45 | Rimmed vacuoles (HP:0003805) | 2.87331217 |
| 46 | Distal lower limb muscle weakness (HP:0009053) | 2.86273416 |
| 47 | Heart block (HP:0012722) | 2.82322032 |
| 48 | Left ventricular hypertrophy (HP:0001712) | 2.80406229 |
| 49 | Areflexia of lower limbs (HP:0002522) | 2.77924474 |
| 50 | Difficulty climbing stairs (HP:0003551) | 2.76502532 |
| 51 | Abnormal EKG (HP:0003115) | 2.71929214 |
| 52 | Abnormal atrioventricular conduction (HP:0005150) | 2.64683190 |
| 53 | Fetal akinesia sequence (HP:0001989) | 2.62175328 |
| 54 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 2.61983967 |
| 55 | Abnormality of skeletal muscle fiber size (HP:0012084) | 2.61144038 |
| 56 | Increased variability in muscle fiber diameter (HP:0003557) | 2.55178129 |
| 57 | Exercise intolerance (HP:0003546) | 2.50477471 |
| 58 | Atrioventricular block (HP:0001678) | 2.47303600 |
| 59 | Congenital malformation of the right heart (HP:0011723) | 2.44037448 |
| 60 | Double outlet right ventricle (HP:0001719) | 2.44037448 |
| 61 | Hepatic necrosis (HP:0002605) | 2.43947499 |
| 62 | Progressive macrocephaly (HP:0004481) | 2.43611322 |
| 63 | Ulnar deviation of the wrist (HP:0003049) | 2.43199804 |
| 64 | Acute encephalopathy (HP:0006846) | 2.42544077 |
| 65 | Progressive muscle weakness (HP:0003323) | 2.42436714 |
| 66 | EMG: neuropathic changes (HP:0003445) | 2.41535312 |
| 67 | Ragged-red muscle fibers (HP:0003200) | 2.40376137 |
| 68 | Weak cry (HP:0001612) | 2.39601096 |
| 69 | Generalized muscle weakness (HP:0003324) | 2.37844739 |
| 70 | Mitochondrial inheritance (HP:0001427) | 2.37444060 |
| 71 | Abnormality of the calcaneus (HP:0008364) | 2.32648363 |
| 72 | Bulbar palsy (HP:0001283) | 2.28138903 |
| 73 | Palmoplantar keratoderma (HP:0000982) | 2.27661332 |
| 74 | Mildly elevated creatine phosphokinase (HP:0008180) | 2.26768215 |
| 75 | Hip contracture (HP:0003273) | 2.22140608 |
| 76 | Increased CSF lactate (HP:0002490) | 2.21929050 |
| 77 | Hepatocellular necrosis (HP:0001404) | 2.20634618 |
| 78 | Slender build (HP:0001533) | 2.18764161 |
| 79 | Muscular dystrophy (HP:0003560) | 2.16134306 |
| 80 | Fatigable weakness (HP:0003473) | 2.13063679 |
| 81 | Abnormality of the neuromuscular junction (HP:0003398) | 2.13063679 |
| 82 | Abnormality of the foot musculature (HP:0001436) | 2.12223811 |
| 83 | Hyperkalemia (HP:0002153) | 2.09645984 |
| 84 | Hypoplastic ischia (HP:0003175) | 2.07742743 |
| 85 | Absent phalangeal crease (HP:0006109) | 2.07604051 |
| 86 | Spinal rigidity (HP:0003306) | 2.02228589 |
| 87 | Conjunctival hamartoma (HP:0100780) | 2.01948364 |
| 88 | Pheochromocytoma (HP:0002666) | 2.01733599 |
| 89 | Abnormality of glycolysis (HP:0004366) | 2.00507948 |
| 90 | Increased serum pyruvate (HP:0003542) | 2.00507948 |
| 91 | Hypoplastic left heart (HP:0004383) | 2.00116943 |
| 92 | Calcaneovalgus deformity (HP:0001848) | 1.99944845 |
| 93 | Abnormality of the shoulder girdle musculature (HP:0001435) | 1.98407822 |
| 94 | Scapular winging (HP:0003691) | 1.98100901 |
| 95 | Waddling gait (HP:0002515) | 1.97568497 |
| 96 | Gowers sign (HP:0003391) | 1.96970188 |
| 97 | Cerebral edema (HP:0002181) | 1.93946051 |
| 98 | Limb-girdle muscle atrophy (HP:0003797) | 1.92659519 |
| 99 | Increased muscle lipid content (HP:0009058) | 1.90043252 |
| 100 | Foot dorsiflexor weakness (HP:0009027) | 1.90024367 |
| 101 | Respiratory insufficiency due to muscle weakness (HP:0002747) | 1.88049869 |
| 102 | Increased intramyocellular lipid droplets (HP:0012240) | 1.83613302 |
| 103 | Neuroendocrine neoplasm (HP:0100634) | 1.82397903 |
| 104 | Ketoacidosis (HP:0001993) | 1.81366480 |
| 105 | Lactic acidosis (HP:0003128) | 1.81078581 |
| 106 | Abnormality of the ischium (HP:0003174) | 1.80343660 |
| 107 | Deformed tarsal bones (HP:0008119) | 1.78694011 |
| 108 | Facial diplegia (HP:0001349) | 1.78451981 |
| 109 | Popliteal pterygium (HP:0009756) | 1.76502626 |
| 110 | Respiratory failure (HP:0002878) | 1.75619870 |
| 111 | Congestive heart failure (HP:0001635) | 1.74078327 |
| 112 | Frequent falls (HP:0002359) | 1.72796951 |
| 113 | Distal lower limb amyotrophy (HP:0008944) | 1.71988474 |
| 114 | Abnormality of alanine metabolism (HP:0010916) | 1.71633630 |
| 115 | Hyperalaninemia (HP:0003348) | 1.71633630 |
| 116 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.71633630 |
| 117 | Abnormality of the musculature of the pelvis (HP:0001469) | 1.71605252 |
| 118 | Abnormality of the hip-girdle musculature (HP:0001445) | 1.71605252 |
| 119 | Limb-girdle muscle weakness (HP:0003325) | 1.70583334 |
| 120 | Proximal amyotrophy (HP:0007126) | 1.69386518 |
| 121 | Shoulder girdle muscle weakness (HP:0003547) | 1.67199089 |
| 122 | Lower limb amyotrophy (HP:0007210) | 1.63270762 |
| 123 | Type 2 muscle fiber atrophy (HP:0003554) | 1.58650724 |
| 124 | Long clavicles (HP:0000890) | 1.56826472 |
| 125 | Metatarsus adductus (HP:0001840) | 1.56620292 |
| 126 | Pelvic girdle muscle weakness (HP:0003749) | 1.52547046 |
| 127 | Ulnar deviation of finger (HP:0009465) | 1.51334925 |
| 128 | Muscle fiber atrophy (HP:0100295) | 1.47315138 |
| 129 | Limited hip movement (HP:0008800) | 1.46403164 |
| 130 | Paralysis (HP:0003470) | 1.45744933 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | OBSCN | 7.77482417 |
| 2 | TTN | 5.38655055 |
| 3 | PHKG1 | 4.42564935 |
| 4 | PHKG2 | 4.42564935 |
| 5 | MYLK | 3.95352505 |
| 6 | DMPK | 3.08844524 |
| 7 | STK24 | 3.00029033 |
| 8 | PIK3CA | 2.90730719 |
| 9 | PDK3 | 2.57697474 |
| 10 | PDK4 | 2.57697474 |
| 11 | LMTK2 | 2.08797484 |
| 12 | MUSK | 2.00858492 |
| 13 | PKN2 | 1.96791959 |
| 14 | NEK1 | 1.95449036 |
| 15 | NME1 | 1.90190547 |
| 16 | ZAK | 1.87053180 |
| 17 | BCKDK | 1.70882681 |
| 18 | PINK1 | 1.68169307 |
| 19 | PDK2 | 1.56315658 |
| 20 | STK38L | 1.54041950 |
| 21 | TIE1 | 1.48356078 |
| 22 | MAP2K3 | 1.47004409 |
| 23 | PIK3CG | 1.46842661 |
| 24 | MAP3K7 | 1.37719623 |
| 25 | TRIB3 | 1.36212377 |
| 26 | CDC42BPA | 1.32178883 |
| 27 | ILK | 1.28373634 |
| 28 | MAPK12 | 1.26584496 |
| 29 | TRPM7 | 1.20108797 |
| 30 | MARK1 | 1.19777150 |
| 31 | LIMK1 | 1.03541841 |
| 32 | PAK3 | 0.99911384 |
| 33 | INSRR | 0.99842078 |
| 34 | ROCK1 | 0.99768045 |
| 35 | CAMK2D | 0.99136693 |
| 36 | ERBB3 | 0.97200963 |
| 37 | PRKAA2 | 0.95555788 |
| 38 | WNK4 | 0.88398975 |
| 39 | PKN1 | 0.87980742 |
| 40 | PRKD1 | 0.87130892 |
| 41 | CCNB1 | 0.86872624 |
| 42 | MOS | 0.86433334 |
| 43 | GRK7 | 0.86360689 |
| 44 | PRKAA1 | 0.81109837 |
| 45 | MAPKAPK3 | 0.71515687 |
| 46 | MAP2K4 | 0.70602878 |
| 47 | EEF2K | 0.70316145 |
| 48 | MAP3K5 | 0.70025202 |
| 49 | DAPK3 | 0.68852933 |
| 50 | STK39 | 0.67502224 |
| 51 | DYRK1B | 0.65850914 |
| 52 | WNK1 | 0.64696884 |
| 53 | PTK2B | 0.62169180 |
| 54 | CAMK1 | 0.60345556 |
| 55 | MAP3K3 | 0.58941330 |
| 56 | ROCK2 | 0.54895118 |
| 57 | CAMK2G | 0.54285639 |
| 58 | STK4 | 0.54083287 |
| 59 | CAMK2A | 0.53214450 |
| 60 | PRKACB | 0.53057584 |
| 61 | FLT3 | 0.52390464 |
| 62 | MAP2K6 | 0.51736491 |
| 63 | KSR2 | 0.49194660 |
| 64 | AKT2 | 0.45691183 |
| 65 | NEK9 | 0.45208624 |
| 66 | MAP2K1 | 0.45025392 |
| 67 | PRKACA | 0.41940655 |
| 68 | PNCK | 0.40948001 |
| 69 | MAPK4 | 0.37971106 |
| 70 | RIPK1 | 0.37837706 |
| 71 | CAMK4 | 0.37035651 |
| 72 | PRKG1 | 0.36693186 |
| 73 | STK38 | 0.34254451 |
| 74 | CDK19 | 0.33044128 |
| 75 | MAP3K13 | 0.32907874 |
| 76 | TAOK2 | 0.32230063 |
| 77 | EPHB2 | 0.31984713 |
| 78 | BRAF | 0.31517882 |
| 79 | PRKCE | 0.31067907 |
| 80 | RPS6KL1 | 0.28365683 |
| 81 | RPS6KC1 | 0.28365683 |
| 82 | RAF1 | 0.28224037 |
| 83 | MAP3K10 | 0.26923237 |
| 84 | SGK3 | 0.26692619 |
| 85 | ARAF | 0.23897772 |
| 86 | MAPK10 | 0.23628805 |
| 87 | PRKACG | 0.23284832 |
| 88 | RPS6KB2 | 0.23259653 |
| 89 | RPS6KB1 | 0.23175797 |
| 90 | SGK2 | 0.23043407 |
| 91 | MARK3 | 0.22231288 |
| 92 | PRKD3 | 0.21103098 |
| 93 | RPS6KA6 | 0.20418678 |
| 94 | SGK1 | 0.20294672 |
| 95 | PAK2 | 0.19991321 |
| 96 | PRPF4B | 0.16610145 |
| 97 | LATS2 | 0.16119023 |
| 98 | PRKCQ | 0.15876194 |
| 99 | KDR | 0.15826851 |
| 100 | TNIK | 0.15729320 |
| 101 | KSR1 | 0.15689991 |
| 102 | PDGFRA | 0.15030406 |
| 103 | RPS6KA3 | 0.14552658 |
| 104 | FER | 0.14366610 |
| 105 | NUAK1 | 0.14338100 |
| 106 | PLK2 | 0.11640873 |
| 107 | PDPK1 | 0.10903433 |
| 108 | MAPK7 | 0.10798465 |
| 109 | TGFBR2 | 0.10205524 |
| 110 | NLK | 0.09658944 |
| 111 | STK3 | 0.09068800 |
| 112 | MAP3K9 | 0.08759127 |
| 113 | RPS6KA2 | 0.08132387 |
| 114 | MAPK11 | 0.07534553 |
| 115 | FGFR1 | 0.07437219 |
| 116 | UHMK1 | 0.07426310 |
| 117 | RPS6KA1 | 0.06734456 |
| 118 | DYRK3 | 0.06718471 |
| 119 | SGK494 | 0.06597017 |
| 120 | SGK223 | 0.06597017 |
| 121 | PDK1 | 0.06586734 |
| 122 | MAPK13 | 0.06506213 |
| 123 | MAP3K1 | 0.06276233 |
| 124 | MAP3K4 | 0.06032168 |
| 125 | GSK3B | 0.05905426 |
| 126 | STK16 | 0.05875882 |
| 127 | DAPK2 | 0.05842431 |
| 128 | PRKDC | 0.05275052 |
| 129 | BMPR1B | 0.05189713 |
| 130 | PLK4 | 0.05042499 |
| 131 | TESK1 | 0.04555170 |
| 132 | CAMK2B | 0.04403399 |
| 133 | PRKCA | 0.04090767 |
| 134 | MAPKAPK2 | 0.04083898 |
| 135 | CDK5 | 0.04076424 |
| 136 | EPHB1 | 0.03978736 |
| 137 | PTK6 | 0.03576663 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 5.42639938 |
| 2 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 5.31797682 |
| 3 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 4.42483798 |
| 4 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 4.17252026 |
| 5 | Parkinsons disease_Homo sapiens_hsa05012 | 3.76916647 |
| 6 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.72282394 |
| 7 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 3.54185572 |
| 8 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 2.94791486 |
| 9 | Alzheimers disease_Homo sapiens_hsa05010 | 2.83828715 |
| 10 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.63943315 |
| 11 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.44729933 |
| 12 | Huntingtons disease_Homo sapiens_hsa05016 | 2.43595184 |
| 13 | Carbon metabolism_Homo sapiens_hsa01200 | 2.25262991 |
| 14 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 2.17010281 |
| 15 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.86852453 |
| 16 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.84130879 |
| 17 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.61592857 |
| 18 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.57727400 |
| 19 | Viral myocarditis_Homo sapiens_hsa05416 | 1.54561335 |
| 20 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.52851606 |
| 21 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.41350246 |
| 22 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.37718679 |
| 23 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 1.36822964 |
| 24 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.34014890 |
| 25 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.20362021 |
| 26 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.20115516 |
| 27 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.11683530 |
| 28 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.11489747 |
| 29 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.05391731 |
| 30 | Insulin resistance_Homo sapiens_hsa04931 | 1.04669641 |
| 31 | Insulin signaling pathway_Homo sapiens_hsa04910 | 1.03550808 |
| 32 | Tight junction_Homo sapiens_hsa04530 | 0.98902052 |
| 33 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.98842109 |
| 34 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.98469095 |
| 35 | Galactose metabolism_Homo sapiens_hsa00052 | 0.96374016 |
| 36 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.91898364 |
| 37 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.90106700 |
| 38 | Focal adhesion_Homo sapiens_hsa04510 | 0.86664880 |
| 39 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.85858528 |
| 40 | Circadian rhythm_Homo sapiens_hsa04710 | 0.84174796 |
| 41 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.83491616 |
| 42 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.82565787 |
| 43 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.81732958 |
| 44 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.81344744 |
| 45 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.81269662 |
| 46 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.74879184 |
| 47 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.74261609 |
| 48 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.71590928 |
| 49 | Long-term potentiation_Homo sapiens_hsa04720 | 0.69577481 |
| 50 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.63673162 |
| 51 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.63300525 |
| 52 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.59062748 |
| 53 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.53970458 |
| 54 | Renin secretion_Homo sapiens_hsa04924 | 0.51565324 |
| 55 | Insulin secretion_Homo sapiens_hsa04911 | 0.49482725 |
| 56 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.48607181 |
| 57 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.47716550 |
| 58 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.46703002 |
| 59 | Circadian entrainment_Homo sapiens_hsa04713 | 0.45161920 |
| 60 | Adherens junction_Homo sapiens_hsa04520 | 0.43337563 |
| 61 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.43117972 |
| 62 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.42043911 |
| 63 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.40103966 |
| 64 | Sulfur relay system_Homo sapiens_hsa04122 | 0.39869658 |
| 65 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.39211090 |
| 66 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.38824639 |
| 67 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.37436206 |
| 68 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.37417915 |
| 69 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.36729847 |
| 70 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.34364292 |
| 71 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.33996765 |
| 72 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.32423674 |
| 73 | Metabolic pathways_Homo sapiens_hsa01100 | 0.30573786 |
| 74 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.29878828 |
| 75 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.28854112 |
| 76 | Lysine degradation_Homo sapiens_hsa00310 | 0.28799962 |
| 77 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.28688925 |
| 78 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.24783242 |
| 79 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.23868814 |
| 80 | Phototransduction_Homo sapiens_hsa04744 | 0.23616430 |
| 81 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.23609894 |
| 82 | Amoebiasis_Homo sapiens_hsa05146 | 0.23540569 |
| 83 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.23442047 |
| 84 | RNA degradation_Homo sapiens_hsa03018 | 0.20103808 |
| 85 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.19380776 |
| 86 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.18641865 |
| 87 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.18374033 |
| 88 | Peroxisome_Homo sapiens_hsa04146 | 0.17806446 |
| 89 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.17545099 |
| 90 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.17515451 |
| 91 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.16643564 |
| 92 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.16482703 |
| 93 | Olfactory transduction_Homo sapiens_hsa04740 | 0.16412668 |
| 94 | Long-term depression_Homo sapiens_hsa04730 | 0.16138210 |
| 95 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.15415104 |
| 96 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.15262770 |
| 97 | Platelet activation_Homo sapiens_hsa04611 | 0.12936078 |
| 98 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.12571641 |
| 99 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.12282348 |
| 100 | Melanogenesis_Homo sapiens_hsa04916 | 0.11976673 |
| 101 | Taste transduction_Homo sapiens_hsa04742 | 0.11913256 |
| 102 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.11764310 |
| 103 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.10972758 |
| 104 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.10662341 |
| 105 | Histidine metabolism_Homo sapiens_hsa00340 | 0.10128538 |
| 106 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.09497261 |
| 107 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.06497633 |
| 108 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.06285021 |
| 109 | Gap junction_Homo sapiens_hsa04540 | 0.05360618 |
| 110 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.04972782 |
| 111 | Salivary secretion_Homo sapiens_hsa04970 | 0.04843751 |
| 112 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.04776814 |
| 113 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.02404451 |
| 114 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.01950482 |
| 115 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.01425939 |
| 116 | Purine metabolism_Homo sapiens_hsa00230 | 0.01383007 |
| 117 | GABAergic synapse_Homo sapiens_hsa04727 | 0.00173392 |
| 118 | Morphine addiction_Homo sapiens_hsa05032 | 0.00084073 |
| 119 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.00029777 |
| 120 | Dopaminergic synapse_Homo sapiens_hsa04728 | -0.0038989 |

