SH3BGRL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.95301505
2thrombin receptor signaling pathway (GO:0070493)5.70841408
3protein neddylation (GO:0045116)5.27330415
4neutrophil activation involved in immune response (GO:0002283)4.85578621
5positive regulation of mast cell activation (GO:0033005)4.72206449
6platelet dense granule organization (GO:0060155)4.49915641
7positive regulation of interferon-alpha production (GO:0032727)4.40302039
8positive regulation by symbiont of host defense response (GO:0052509)4.34047735
9modulation by symbiont of host defense response (GO:0052031)4.34047735
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.34047735
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.34047735
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.34047735
13modulation by symbiont of host immune response (GO:0052553)4.34047735
14regulation of interferon-alpha production (GO:0032647)4.13359016
15regulation of platelet aggregation (GO:0090330)4.03222325
16production of molecular mediator involved in inflammatory response (GO:0002532)4.03125508
17regulation of interferon-beta biosynthetic process (GO:0045357)3.95249152
18positive regulation of mast cell activation involved in immune response (GO:0033008)3.94426289
19positive regulation of mast cell degranulation (GO:0043306)3.94426289
20regulation of platelet activation (GO:0010543)3.86258551
21antigen processing and presentation of endogenous antigen (GO:0019883)3.80212476
22response to peptidoglycan (GO:0032494)3.69819838
23positive regulation of B cell differentiation (GO:0045579)3.68917089
24negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.62541312
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.60853499
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.60853499
27positive regulation of gamma-delta T cell activation (GO:0046645)3.57403150
28cellular response to zinc ion (GO:0071294)3.53839468
29detection of molecule of bacterial origin (GO:0032490)3.49986315
30positive regulation of natural killer cell differentiation (GO:0032825)3.43764465
31response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.41220779
32response to host immune response (GO:0052572)3.41220779
33response to interferon-alpha (GO:0035455)3.40592923
34sequestering of actin monomers (GO:0042989)3.38836605
35positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.33584062
36purinergic nucleotide receptor signaling pathway (GO:0035590)3.32207037
37positive regulation of macrophage cytokine production (GO:0060907)3.27208075
38negative regulation of neurotransmitter transport (GO:0051589)3.27128889
39negative regulation of interleukin-17 production (GO:0032700)3.26848886
40negative regulation of mast cell activation (GO:0033004)3.26427220
41phagocytosis, engulfment (GO:0006911)3.26163696
42regulation of mast cell degranulation (GO:0043304)3.25777528
43Arp2/3 complex-mediated actin nucleation (GO:0034314)3.24327230
44positive regulation of granulocyte differentiation (GO:0030854)3.23031945
45regulation of B cell receptor signaling pathway (GO:0050855)3.23000697
46B cell mediated immunity (GO:0019724)3.22739158
47macrophage activation involved in immune response (GO:0002281)3.22587417
48positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.21456994
49positive regulation of chemokine biosynthetic process (GO:0045080)3.18690216
50regulation of mast cell activation involved in immune response (GO:0033006)3.17693089
51neutrophil activation (GO:0042119)3.17356699
52negative regulation of phagocytosis (GO:0050765)3.15896435
53G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.14381950
54respiratory burst (GO:0045730)3.07492035
55granulocyte activation (GO:0036230)3.07250347
56positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.05692037
57immunoglobulin mediated immune response (GO:0016064)3.05434361
58regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.04317356
59response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.03396543
60response to host (GO:0075136)3.03396543
61response to host defenses (GO:0052200)3.03396543
62T-helper 1 type immune response (GO:0042088)3.01964738
63lipopolysaccharide-mediated signaling pathway (GO:0031663)3.00608382
64leukocyte migration involved in inflammatory response (GO:0002523)2.99837618
65cellular extravasation (GO:0045123)2.98991559
66regulation of T cell chemotaxis (GO:0010819)2.97814524
67positive regulation of T cell chemotaxis (GO:0010820)2.97814524
68negative regulation of viral genome replication (GO:0045071)2.97040090
69positive regulation of macrophage differentiation (GO:0045651)2.94750756
70regulation of T-helper 1 cell differentiation (GO:0045625)2.94501829
71response to type I interferon (GO:0034340)2.93531078
72cellular response to type I interferon (GO:0071357)2.93530411
73type I interferon signaling pathway (GO:0060337)2.93530411
74regulation of chemokine biosynthetic process (GO:0045073)2.90752317
75defense response to protozoan (GO:0042832)2.90129245
76regulation of interleukin-17 production (GO:0032660)2.89841698
77positive regulation of monocyte chemotaxis (GO:0090026)2.88987152
78regulation of dendritic cell antigen processing and presentation (GO:0002604)2.88986090
79positive regulation of interleukin-12 production (GO:0032735)2.88957489
80response to interferon-beta (GO:0035456)2.88284402
81regulation of mononuclear cell migration (GO:0071675)2.88063515
82myeloid dendritic cell activation (GO:0001773)2.87859185
83positive regulation of interferon-beta production (GO:0032728)2.86240722
84leukocyte degranulation (GO:0043299)2.86128299
85megakaryocyte development (GO:0035855)2.85371478
86regulation of macrophage cytokine production (GO:0010935)2.83914954
87positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.83754459
88positive regulation of vasculogenesis (GO:2001214)2.81266991
89hydrogen peroxide biosynthetic process (GO:0050665)2.80869749
90regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.80607141
91positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.80475005
92interferon-gamma-mediated signaling pathway (GO:0060333)2.78957832
93positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.78145690
94regulation of monocyte chemotaxis (GO:0090025)2.77936697
95positive regulation of antigen processing and presentation (GO:0002579)2.77280337
96adenosine metabolic process (GO:0046085)2.75992154
97relaxation of smooth muscle (GO:0044557)2.74552929
98negative regulation of thymocyte apoptotic process (GO:0070244)2.74439341
99actin nucleation (GO:0045010)2.73298667
100cellular response to exogenous dsRNA (GO:0071360)2.73055150
101negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.71978389
102regulation of MHC class II biosynthetic process (GO:0045346)2.71881608
103negative regulation of lipid storage (GO:0010888)2.71338156
104positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.70213705
105positive regulation of T cell migration (GO:2000406)2.69670130
106myeloid dendritic cell differentiation (GO:0043011)2.68303393
107reactive oxygen species biosynthetic process (GO:1903409)2.68117754
108cellular response to interferon-beta (GO:0035458)2.67612872
109mast cell activation (GO:0045576)2.66656874
110positive regulation of chemokine production (GO:0032722)2.66656270
111lipoxygenase pathway (GO:0019372)2.65251408
112response to muramyl dipeptide (GO:0032495)2.65112614
113epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.64858540
114regulation of hypersensitivity (GO:0002883)2.64364608
115superoxide anion generation (GO:0042554)2.64009697
116positive regulation of toll-like receptor signaling pathway (GO:0034123)2.63729087
117myeloid cell activation involved in immune response (GO:0002275)2.63496900
118microglial cell activation (GO:0001774)2.63084293
119purinergic receptor signaling pathway (GO:0035587)2.62999116
120response to protozoan (GO:0001562)2.62844265
121natural killer cell mediated immunity (GO:0002228)2.62632152
122natural killer cell mediated cytotoxicity (GO:0042267)2.62632152
123regulation of B cell differentiation (GO:0045577)2.62001362
124secretory granule organization (GO:0033363)2.61632978
125positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.60903285
126regulation of cholesterol storage (GO:0010885)2.59726002
127adenosine receptor signaling pathway (GO:0001973)2.58870830
128regulation of integrin-mediated signaling pathway (GO:2001044)2.58361668
129positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.58025034
130macrophage activation (GO:0042116)2.57971585
131regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.57666785
132signal peptide processing (GO:0006465)2.57441082
133cell adhesion mediated by integrin (GO:0033627)2.57096597
134negative regulation of heart rate (GO:0010459)2.56705833
135positive regulation of lymphocyte migration (GO:2000403)2.56688534
136negative regulation of interleukin-12 production (GO:0032695)2.56321407
137positive regulation of alpha-beta T cell proliferation (GO:0046641)2.55492073
138negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.54443895
139detection of external biotic stimulus (GO:0098581)2.53887395
140positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.53419303
141regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.53246840
142purine-containing compound salvage (GO:0043101)2.53042121
143peptide catabolic process (GO:0043171)2.52659420
144histamine secretion (GO:0001821)2.52161790
145regulation of cellular extravasation (GO:0002691)2.50461519
146endosome to melanosome transport (GO:0035646)2.49989009
147endosome to pigment granule transport (GO:0043485)2.49989009
148negative regulation of neurotransmitter secretion (GO:0046929)2.49471851
149cell wall macromolecule catabolic process (GO:0016998)2.49433130
150regulation of antigen processing and presentation (GO:0002577)2.48938046
151regulation of mast cell activation (GO:0033003)2.48917979
152positive regulation of type 2 immune response (GO:0002830)2.48904815
153myeloid leukocyte activation (GO:0002274)2.48800410
154dendritic cell differentiation (GO:0097028)2.48253039
155regulation of inositol phosphate biosynthetic process (GO:0010919)2.48078337
156membrane invagination (GO:0010324)2.47888443
157regulation of interleukin-12 biosynthetic process (GO:0045075)2.47273682
158regulation of alpha-beta T cell proliferation (GO:0046640)2.45730254
159monoamine transport (GO:0015844)2.45136815
160negative regulation of appetite (GO:0032099)2.43878016
161negative regulation of response to food (GO:0032096)2.43878016
162regulation of myeloid leukocyte mediated immunity (GO:0002886)2.42998020
163regulation of memory T cell differentiation (GO:0043380)2.42683551
164negative regulation of T-helper cell differentiation (GO:0045623)2.41219024
165negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.41219024
166positive regulation of interleukin-1 beta secretion (GO:0050718)2.41054118
167negative regulation of platelet activation (GO:0010544)2.40331114
168positive regulation of leukocyte degranulation (GO:0043302)2.39503445
169positive regulation of endothelial cell differentiation (GO:0045603)2.39192202
170detection of other organism (GO:0098543)2.38486690
171positive regulation of interleukin-17 production (GO:0032740)2.38363913
172positive regulation of B cell mediated immunity (GO:0002714)2.37877350
173positive regulation of immunoglobulin mediated immune response (GO:0002891)2.37877350
174cellular response to thyroid hormone stimulus (GO:0097067)2.37761929
175xenobiotic catabolic process (GO:0042178)2.36732466

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.30701775
2* IRF8_21731497_ChIP-ChIP_J774_Mouse5.54011425
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.31171220
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.42136262
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.06604488
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.63311930
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.57832632
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.40397992
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.14489780
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.09749015
11TRIM28_21343339_ChIP-Seq_HEK293_Human3.00537720
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.90151601
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.78631065
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.62152866
15* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.46261617
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.44903970
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.43691539
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.32484609
19CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.19090010
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.12277472
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.08019549
22SMAD_19615063_ChIP-ChIP_OVARY_Human2.07853075
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.07337584
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.06905622
25NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.05595901
26NRF2_20460467_ChIP-Seq_MEFs_Mouse2.05595901
27CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.01112440
28TAF15_26573619_Chip-Seq_HEK293_Human2.00276968
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.98310964
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.92748797
31CLOCK_20551151_ChIP-Seq_293T_Human1.86436779
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84314048
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.82533485
34WT1_19549856_ChIP-ChIP_CCG9911_Human1.81913041
35EWS_26573619_Chip-Seq_HEK293_Human1.81491952
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.81124747
37* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.76923429
38GATA1_22025678_ChIP-Seq_K562_Human1.75619120
39* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.72758919
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.72298311
41VDR_24787735_ChIP-Seq_THP-1_Human1.71376877
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.70812591
43SPI1_23547873_ChIP-Seq_NB4_Human1.70200410
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.70038176
45GBX2_23144817_ChIP-Seq_PC3_Human1.66398522
46CJUN_26792858_Chip-Seq_BT549_Human1.64579014
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64295618
48VDR_22108803_ChIP-Seq_LS180_Human1.64086177
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.61706698
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.59108102
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58346669
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56803528
53PU_27001747_Chip-Seq_BMDM_Mouse1.52499778
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.51666845
55PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51646316
56SOX2_20726797_ChIP-Seq_SW620_Human1.50495225
57MYB_26560356_Chip-Seq_TH2_Human1.45688701
58GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43395791
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41982031
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41673927
61SCL_19346495_ChIP-Seq_HPC-7_Human1.37099632
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37020453
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36382021
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35856256
65TP53_18474530_ChIP-ChIP_U2OS_Human1.33267369
66* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32928928
67ELK1_19687146_ChIP-ChIP_HELA_Human1.32176622
68BRD4_25478319_ChIP-Seq_HGPS_Human1.31672641
69IGF1R_20145208_ChIP-Seq_DFB_Human1.31424601
70ZNF274_21170338_ChIP-Seq_K562_Hela1.29893967
71ER_23166858_ChIP-Seq_MCF-7_Human1.28826155
72* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28496742
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.27246221
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26961650
75RUNX_20019798_ChIP-Seq_JUKART_Human1.26110129
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25487662
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25378988
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23324704
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23142560
80NANOG_19829295_ChIP-Seq_ESCs_Human1.22903961
81SOX2_19829295_ChIP-Seq_ESCs_Human1.22903961
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22636584
83P53_22387025_ChIP-Seq_ESCs_Mouse1.21561524
84PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21311383
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21042702
86FUS_26573619_Chip-Seq_HEK293_Human1.20771429
87IRF1_19129219_ChIP-ChIP_H3396_Human1.18946927
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.17824371
89* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17595246
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17095448
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16685964
92NFE2_27457419_Chip-Seq_LIVER_Mouse1.16436213
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15676299
94IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15255399
95VDR_24763502_ChIP-Seq_THP-1_Human1.14483949
96SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13670631
97TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13200521
98SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12983973
99SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12983973
100CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12735962
101EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11953773
102OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09849424
103SMAD4_21799915_ChIP-Seq_A2780_Human1.08917088
104E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07290699
105CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06593481
106FLI1_21867929_ChIP-Seq_TH2_Mouse1.05910224
107FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05608035
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05534821
109RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.05450809
110E2F1_18555785_Chip-Seq_ESCs_Mouse1.04514546
111CMYC_18555785_Chip-Seq_ESCs_Mouse1.03524963
112TAL1_26923725_Chip-Seq_HPCs_Mouse1.02548531
113AR_20517297_ChIP-Seq_VCAP_Human1.02010035
114GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01756677
115SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01739296
116RUNX1_22412390_ChIP-Seq_EML_Mouse1.01485170
117BCAT_22108803_ChIP-Seq_LS180_Human1.00884701
118AR_25329375_ChIP-Seq_VCAP_Human1.00533305
119EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00103959
120SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99884652
121EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99692540
122GATA3_26560356_Chip-Seq_TH2_Human0.99138678
123SPI1_23127762_ChIP-Seq_K562_Human0.98736068
124CDX2_22108803_ChIP-Seq_LS180_Human0.98706203
125SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98678320
126CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97946310
127PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96927250
128MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96195650
129RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95750784
130TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94682520
131CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91159372
132* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.90797675
133* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.88592850
134HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.88503833
135GATA3_27048872_Chip-Seq_THYMUS_Human0.87322389
136MYB_26560356_Chip-Seq_TH1_Human0.87144052
137TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.83639571
138LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.81356773
139GATA2_22383799_ChIP-Seq_G1ME_Mouse0.79948984
140ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.79671617
141BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78867153
142JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78026471
143P300_19829295_ChIP-Seq_ESCs_Human0.77016051
144MAF_26560356_Chip-Seq_TH1_Human0.76490753
145SALL4_22934838_ChIP-ChIP_CD34+_Human0.76095738
146CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72457089
147LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.72340122
148PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.71916126
149ERG_20887958_ChIP-Seq_HPC-7_Mouse0.71819956
150RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.71262065
151* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.71140128
152ESR1_20079471_ChIP-ChIP_T-47D_Human0.70008790
153CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.69496085

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.33367960
2MP0008438_abnormal_cutaneous_collagen3.85699682
3MP0003724_increased_susceptibility_to3.30332310
4MP0009785_altered_susceptibility_to3.15433437
5MP0002148_abnormal_hypersensitivity_rea2.97817527
6MP0003436_decreased_susceptibility_to2.84553330
7MP0008004_abnormal_stomach_pH2.52311943
8MP0006054_spinal_hemorrhage2.50413689
9MP0002419_abnormal_innate_immunity2.46284928
10MP0001879_abnormal_lymphatic_vessel2.40069868
11MP0005000_abnormal_immune_tolerance2.27972012
12MP0005025_abnormal_response_to2.12127786
13MP0005503_abnormal_tendon_morphology2.10500355
14MP0001790_abnormal_immune_system2.06214406
15MP0005387_immune_system_phenotype2.06214406
16MP0000685_abnormal_immune_system2.05868645
17MP0006082_CNS_inflammation2.01764504
18MP0002166_altered_tumor_susceptibility2.01641020
19MP0001533_abnormal_skeleton_physiology1.97165984
20MP0002452_abnormal_antigen_presenting1.94468387
21MP0002006_tumorigenesis1.92947635
22MP0003303_peritoneal_inflammation1.89686923
23MP0001958_emphysema1.89343031
24MP0003279_aneurysm1.87632424
25MP0005671_abnormal_response_to1.85084838
26MP0005275_abnormal_skin_tensile1.80392709
27MP0009764_decreased_sensitivity_to1.77611498
28MP0003705_abnormal_hypodermis_morpholog1.75107408
29MP0000343_altered_response_to1.67642370
30MP0004782_abnormal_surfactant_physiolog1.65162779
31MP0003172_abnormal_lysosome_physiology1.62837425
32MP0001853_heart_inflammation1.61093021
33MP0001819_abnormal_immune_cell1.60586079
34MP0002723_abnormal_immune_serum1.60555131
35MP0010368_abnormal_lymphatic_system1.60371059
36MP0002420_abnormal_adaptive_immunity1.56732286
37MP0001800_abnormal_humoral_immune1.55828482
38MP0003448_altered_tumor_morphology1.54395582
39MP0005464_abnormal_platelet_physiology1.53964982
40MP0003191_abnormal_cellular_cholesterol1.48996296
41MP0000858_altered_metastatic_potential1.48445655
42MP0000569_abnormal_digit_pigmentation1.46471714
43MP0005164_abnormal_response_to1.45307940
44MP0002998_abnormal_bone_remodeling1.44549483
45MP0005058_abnormal_lysosome_morphology1.44044430
46MP0000767_abnormal_smooth_muscle1.43363585
47MP0001845_abnormal_inflammatory_respons1.43221857
48MP0004883_abnormal_blood_vessel1.42025581
49MP0005397_hematopoietic_system_phenotyp1.39238427
50MP0001545_abnormal_hematopoietic_system1.39238427
51MP0003656_abnormal_erythrocyte_physiolo1.39191240
52MP0003186_abnormal_redox_activity1.37994254
53MP0003828_pulmonary_edema1.32682804
54MP0002405_respiratory_system_inflammati1.31653219
55MP0010386_abnormal_urinary_bladder1.31565414
56MP0005390_skeleton_phenotype1.31560694
57MP0001851_eye_inflammation1.29321622
58MP0001542_abnormal_bone_strength1.29023192
59MP0000230_abnormal_systemic_arterial1.25178538
60MP0002009_preneoplasia1.23253774
61MP0004147_increased_porphyrin_level1.23004652
62MP0008469_abnormal_protein_level1.22136197
63MP0005075_abnormal_melanosome_morpholog1.21039625
64MP0010155_abnormal_intestine_physiology1.18678726
65MP0002295_abnormal_pulmonary_circulatio1.16807652
66MP0002138_abnormal_hepatobiliary_system1.16573833
67MP0004272_abnormal_basement_membrane1.16215464
68MP0004808_abnormal_hematopoietic_stem1.16060606
69MP0005174_abnormal_tail_pigmentation1.13234866
70MP0002876_abnormal_thyroid_physiology1.13231485
71MP0002132_abnormal_respiratory_system1.12108675
72MP0000249_abnormal_blood_vessel1.11374023
73MP0009278_abnormal_bone_marrow1.10919056
74MP0000681_abnormal_thyroid_gland1.10606354
75MP0003300_gastrointestinal_ulcer1.09692486
76MP0000716_abnormal_immune_system1.09461622
77MP0002722_abnormal_immune_system1.07807251
78MP0003075_altered_response_to1.07806271
79MP0001986_abnormal_taste_sensitivity1.06066228
80MP0005646_abnormal_pituitary_gland1.05520362
81MP0010352_gastrointestinal_tract_polyps1.04640886
82MP0002877_abnormal_melanocyte_morpholog1.03444094
83MP0005084_abnormal_gallbladder_morpholo1.01728384
84MP0003011_delayed_dark_adaptation1.00790967
85MP0002398_abnormal_bone_marrow1.00507029
86MP0000465_gastrointestinal_hemorrhage1.00022647
87MP0009765_abnormal_xenobiotic_induced0.99367655
88MP0003091_abnormal_cell_migration0.99273115
89MP0004084_abnormal_cardiac_muscle0.98231217
90MP0005166_decreased_susceptibility_to0.97892172
91MP0003787_abnormal_imprinting0.96040645
92MP0002736_abnormal_nociception_after0.92025968
93MP0002396_abnormal_hematopoietic_system0.91157800
94MP0001915_intracranial_hemorrhage0.91023068
95MP0001663_abnormal_digestive_system0.90324633
96MP0002933_joint_inflammation0.90184609
97MP0005253_abnormal_eye_physiology0.89879086
98MP0002282_abnormal_trachea_morphology0.89380861
99MP0008789_abnormal_olfactory_epithelium0.89198547
100MP0009384_cardiac_valve_regurgitation0.89141360
101MP0003943_abnormal_hepatobiliary_system0.89112510
102MP0000015_abnormal_ear_pigmentation0.88109701
103MP0004510_myositis0.87182300
104MP0003795_abnormal_bone_structure0.87180122
105MP0002429_abnormal_blood_cell0.87144622
106MP0006072_abnormal_retinal_apoptosis0.86037998
107MP0001764_abnormal_homeostasis0.84898978
108MP0009763_increased_sensitivity_to0.82948356
109MP0000516_abnormal_urinary_system0.82796390
110MP0005367_renal/urinary_system_phenotyp0.82796390
111MP0009697_abnormal_copulation0.82627883
112MP0002133_abnormal_respiratory_system0.81245538
113MP0005388_respiratory_system_phenotype0.81245538
114MP0005167_abnormal_blood-brain_barrier0.80593068
115MP0000689_abnormal_spleen_morphology0.79392648
116MP0005076_abnormal_cell_differentiation0.77322987
117MP0005535_abnormal_body_temperature0.77146206
118MP0004484_altered_response_of0.76303337
119MP0002928_abnormal_bile_duct0.75108602
120MP0005410_abnormal_fertilization0.74982010
121MP0003183_abnormal_peptide_metabolism0.74933209
122MP0003638_abnormal_response/metabolism_0.74642237
123MP0005197_abnormal_uvea_morphology0.74430069
124MP0003880_abnormal_central_pattern0.74263096
125MP0009333_abnormal_splenocyte_physiolog0.73774560
126MP0009115_abnormal_fat_cell0.73547829
127MP0008872_abnormal_physiological_respon0.72085486
128MP0002113_abnormal_skeleton_development0.71318185
129MP0008775_abnormal_heart_ventricle0.71113537
130MP0002163_abnormal_gland_morphology0.70726082
131MP0004947_skin_inflammation0.70423358
132MP0003252_abnormal_bile_duct0.69841441
133MP0002102_abnormal_ear_morphology0.69298110
134MP0005165_increased_susceptibility_to0.69169173
135MP0002090_abnormal_vision0.69141374
136MP0000372_irregular_coat_pigmentation0.68864940
137MP0003866_abnormal_defecation0.68823459
138MP0003763_abnormal_thymus_physiology0.67721796

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)6.19033540
2Recurrent abscess formation (HP:0002722)4.92882114
3Eczematoid dermatitis (HP:0000976)4.73122166
4Recurrent gram-negative bacterial infections (HP:0005420)4.68511589
5Increased mean platelet volume (HP:0011877)4.58921450
6Abnormal platelet volume (HP:0011876)4.56288731
7Recurrent bacterial skin infections (HP:0005406)4.44157583
8Epistaxis (HP:0000421)4.30921525
9Stomatitis (HP:0010280)4.25386932
10Menorrhagia (HP:0000132)3.74899884
11Gingival bleeding (HP:0000225)3.72645999
12Myositis (HP:0100614)3.60287050
13Autoimmune thrombocytopenia (HP:0001973)3.45140871
14Vacuolated lymphocytes (HP:0001922)3.43436461
15Orchitis (HP:0100796)3.33298331
16Systemic lupus erythematosus (HP:0002725)3.32570052
17Elevated erythrocyte sedimentation rate (HP:0003565)3.31440386
18Dyschromatopsia (HP:0007641)3.22149029
19Hematochezia (HP:0002573)3.14826336
20Spinal cord lesions (HP:0100561)3.12687090
21Syringomyelia (HP:0003396)3.12687090
22Mediastinal lymphadenopathy (HP:0100721)3.12238229
23Optic neuritis (HP:0100653)3.03656996
24Retrobulbar optic neuritis (HP:0100654)3.03656996
25Increased cerebral lipofuscin (HP:0011813)2.97750640
26Increased neuronal autofluorescent lipopigment (HP:0002074)2.95423239
27Abnormality of macrophages (HP:0004311)2.92494360
28Asymmetry of the thorax (HP:0001555)2.92275114
29Osteolytic defects of the hand bones (HP:0009699)2.90780881
30Osteolytic defects of the phalanges of the hand (HP:0009771)2.90780881
31Impaired platelet aggregation (HP:0003540)2.88888777
32Abnormal platelet function (HP:0011869)2.88888777
33Vertebral compression fractures (HP:0002953)2.86850684
34Aortic aneurysm (HP:0004942)2.83506728
35Subacute progressive viral hepatitis (HP:0006572)2.82779333
36Periodontitis (HP:0000704)2.72488003
37Panhypogammaglobulinemia (HP:0003139)2.65617512
38Disinhibition (HP:0000734)2.65599634
39Abnormality of liposaccharide metabolism (HP:0010968)2.65005526
40Abnormality of glycosphingolipid metabolism (HP:0004343)2.65005526
41Abnormality of glycolipid metabolism (HP:0010969)2.65005526
42Vascular tortuosity (HP:0004948)2.64524687
43Peritonitis (HP:0002586)2.63015559
44Abnormality of the heme biosynthetic pathway (HP:0010472)2.61148792
45Arterial thrombosis (HP:0004420)2.56120383
46Gingivitis (HP:0000230)2.55772830
47Interstitial pulmonary disease (HP:0006530)2.54694497
48Absent frontal sinuses (HP:0002688)2.54559204
49Spontaneous hematomas (HP:0007420)2.54255260
50Decreased central vision (HP:0007663)2.53517017
51Protrusio acetabuli (HP:0003179)2.51878268
52Encephalitis (HP:0002383)2.51688534
53Aortic dissection (HP:0002647)2.50949950
54Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.49552547
55Abolished electroretinogram (ERG) (HP:0000550)2.48976996
56Cellulitis (HP:0100658)2.45667178
57Vasculitis (HP:0002633)2.45411799
58Recurrent skin infections (HP:0001581)2.45389438
59Hepatosplenomegaly (HP:0001433)2.42264810
60Osteomyelitis (HP:0002754)2.40287878
61Conjunctival telangiectasia (HP:0000524)2.39267049
62Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.37340525
63True hermaphroditism (HP:0010459)2.36191755
64Basal ganglia calcification (HP:0002135)2.34377096
65Leukocytosis (HP:0001974)2.33780527
66Obstructive lung disease (HP:0006536)2.29600464
67Chronic obstructive pulmonary disease (HP:0006510)2.29600464
68Dynein arm defect of respiratory motile cilia (HP:0012255)2.29090301
69Absent/shortened dynein arms (HP:0200106)2.29090301
70Myocardial infarction (HP:0001658)2.27732748
71Prostate neoplasm (HP:0100787)2.27725645
72Thrombocytosis (HP:0001894)2.26173911
73Abnormality of B cell number (HP:0010975)2.26069971
74Glomerulonephritis (HP:0000099)2.25583435
753-Methylglutaconic aciduria (HP:0003535)2.23871809
76Abnormality of T cell number (HP:0011839)2.23864374
77Mucosal telangiectasiae (HP:0100579)2.23258173
78Pulmonary infiltrates (HP:0002113)2.23203278
79T lymphocytopenia (HP:0005403)2.23129846
80Abnormality of lateral ventricle (HP:0030047)2.20658129
81Spondylolisthesis (HP:0003302)2.20311135
82Increased IgM level (HP:0003496)2.18814011
83Dilatation of the ascending aorta (HP:0005111)2.18635618
84Abnormal ciliary motility (HP:0012262)2.17829111
85Chest pain (HP:0100749)2.16781496
86Polyphagia (HP:0002591)2.15390057
87Recurrent fungal infections (HP:0002841)2.14889136
88Recurrent pneumonia (HP:0006532)2.14884793
89Abnormality of the prostate (HP:0008775)2.14151251
90Abnormality of the lumbar spine (HP:0100712)2.12931987
91Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.12592541
92Abnormal respiratory motile cilium morphology (HP:0005938)2.11202883
93Abnormal respiratory epithelium morphology (HP:0012253)2.11202883
94Cervical subluxation (HP:0003308)2.08989637
95Bone cyst (HP:0012062)2.08666310
96Hyperlipoproteinemia (HP:0010980)2.08511911
97Papilledema (HP:0001085)2.08118571
98Abnormality of the frontal sinuses (HP:0002687)2.06955672
99Eosinophilia (HP:0001880)2.06581481
100Viral hepatitis (HP:0006562)2.04663964
101Abnormality of complement system (HP:0005339)2.04642243
102Constricted visual fields (HP:0001133)2.02450505
103B lymphocytopenia (HP:0010976)2.01979016
104Gastrointestinal infarctions (HP:0005244)2.01527262
105Nephritis (HP:0000123)2.01093761
106Chronic mucocutaneous candidiasis (HP:0002728)2.00620711
107Recurrent cutaneous fungal infections (HP:0011370)2.00620711
108Episodic fever (HP:0001954)1.98692207
109Petechiae (HP:0000967)1.98128136
110Medial flaring of the eyebrow (HP:0010747)1.97850327
111Hemoptysis (HP:0002105)1.96277234
112Recurrent lower respiratory tract infections (HP:0002783)1.96085293
113Pulmonary artery stenosis (HP:0004415)1.95255356
114Pulmonary embolism (HP:0002204)1.94961846
115Arterial tortuosity (HP:0005116)1.94773587
116Mitral stenosis (HP:0001718)1.94672843
117Recurrent viral infections (HP:0004429)1.94663398
118Poor head control (HP:0002421)1.94387084
119Cutaneous melanoma (HP:0012056)1.94085306
120Metaphyseal dysplasia (HP:0100255)1.93567172
121Thyroiditis (HP:0100646)1.93285122
122Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92800443
123Keratoconjunctivitis sicca (HP:0001097)1.92248943
124Abnormal delayed hypersensitivity skin test (HP:0002963)1.90605659
125Hypothermia (HP:0002045)1.90196539
126Abnormality of eosinophils (HP:0001879)1.89822361
127Meningitis (HP:0001287)1.88807888
128Albinism (HP:0001022)1.87847820
129Nephronophthisis (HP:0000090)1.86030911
130Wormian bones (HP:0002645)1.85758531
131Granulocytopenia (HP:0001913)1.85137729
132Dysostosis multiplex (HP:0000943)1.84942610
133Aortic valve stenosis (HP:0001650)1.84810461
134Hypochromic microcytic anemia (HP:0004840)1.84443898
135Abnormality of the pericardium (HP:0001697)1.83621768
136Premature rupture of membranes (HP:0001788)1.83565803
137Alveolar cell carcinoma (HP:0006519)1.83511379
138Micronodular cirrhosis (HP:0001413)1.83232582
139Urticaria (HP:0001025)1.82343403
140Mucopolysacchariduria (HP:0008155)1.82028496
141Urinary glycosaminoglycan excretion (HP:0003541)1.82028496
142Joint swelling (HP:0001386)1.81924897
143Recurrent bronchitis (HP:0002837)1.80764526
144Autoimmune hemolytic anemia (HP:0001890)1.79971092
145Recurrent sinusitis (HP:0011108)1.79709176
146Delayed closure of the anterior fontanelle (HP:0001476)1.79337178
147Joint hemorrhage (HP:0005261)1.79100765
148Exertional dyspnea (HP:0002875)1.78851955
149Molar tooth sign on MRI (HP:0002419)1.78486921
150Abnormality of midbrain morphology (HP:0002418)1.78486921
151Tetraparesis (HP:0002273)1.78347602
152Thyroid-stimulating hormone excess (HP:0002925)1.78008055
153Abnormal pupillary function (HP:0007686)1.77510737
154Poikilocytosis (HP:0004447)1.77472746
155Glomerulopathy (HP:0100820)1.77131573
156Abnormality of the vasculature of the conjunctiva (HP:0008054)1.76569832
157Disproportionate short-trunk short stature (HP:0003521)1.76032580
158Purpura (HP:0000979)1.75800807
159Chronic otitis media (HP:0000389)1.74784001
160Abnormality of the pleura (HP:0002103)1.73655902
161Thrombophlebitis (HP:0004418)1.72543594
162Hypergammaglobulinemia (HP:0010702)1.72183438
163Heterochromia iridis (HP:0001100)1.71966073

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB34.06787450
2MAP3K143.78167086
3CDK193.33430106
4FRK2.99666290
5BLK2.68729302
6MAP4K22.57444434
7TBK12.55117791
8NEK92.52777473
9KIT2.41218903
10PBK2.14703547
11IRAK42.13874531
12EPHA32.11803264
13JAK31.94822773
14TGFBR21.92009854
15PIM21.89432279
16RIPK41.83596695
17TYK21.78986908
18NUAK11.73922316
19FES1.64614927
20ADRBK21.58054407
21BMPR21.57923509
22TGFBR11.56642386
23PINK11.53124153
24IKBKB1.51754113
25YES11.50670343
26IKBKE1.50221957
27CHUK1.49037050
28FGFR31.46336748
29MYLK1.45444657
30TESK11.44139698
31JAK11.42737208
32RIPK11.41998607
33SIK31.40526094
34CSF1R1.40385076
35TRPM71.37854348
36TNK21.37171423
37ERN11.36077005
38TEC1.35965417
39TRIM281.35784297
40FGR1.30435646
41BMPR1B1.28549276
42TXK1.27772008
43EIF2AK21.23842861
44MAP3K121.23832398
45WNK31.23587319
46GRK61.22459273
47SCYL21.20689536
48CSNK1G31.16704927
49RPS6KA41.16494882
50ITK1.13662388
51ZAK1.08566197
52BCKDK1.08378717
53SYK1.06539208
54TIE11.06170998
55PLK21.04263741
56CSNK1G21.04057386
57PIK3CG1.03172110
58MAPK131.02412220
59EPHB20.99648147
60ABL20.97447906
61CSNK1G10.93954251
62ZAP700.93494896
63IRAK30.92120355
64BTK0.91879836
65MATK0.91112260
66TRIB30.90392164
67ACVR1B0.90111541
68CDK60.89849086
69LYN0.88744341
70MST40.84920046
71LRRK20.83860352
72LIMK10.83405822
73GRK70.81952958
74GRK50.78705685
75CAMKK20.78029541
76DYRK30.77829129
77PTK60.76474969
78DAPK20.73629358
79EIF2AK10.72850920
80CSNK1A1L0.72160771
81PIK3CA0.71619024
82PDGFRA0.71342833
83BMX0.71217655
84MAP4K10.68812920
85TNIK0.68777068
86FLT30.68316425
87DDR20.68235901
88PRKCQ0.65954345
89PRKCD0.63972672
90JAK20.63649223
91MKNK10.63388702
92ERBB40.63064824
93PIM10.61645124
94CDK80.60242671
95MAP3K50.58780746
96ABL10.58749416
97HCK0.57667447
98RPS6KA60.57561772
99GRK10.57513277
100STK30.57154791
101FER0.57060075
102BCR0.56420375
103BRSK20.56178216
104PAK40.56051793
105EIF2AK30.56047042
106MAP3K40.55675926
107CAMK1D0.55310797
108VRK10.55149317
109DYRK20.55048310
110CSK0.54745888
111IGF1R0.54182608
112TAOK20.53842924
113TTN0.52175191
114LCK0.51812580
115ADRBK10.51095688
116NME20.49242702
117MAPKAPK20.48783749
118RPS6KA20.48443684
119FGFR40.47226995
120MAP2K30.46522036
121MST1R0.46408516
122PTK2B0.45871099
123FYN0.45619043
124ILK0.44529802
125PRKG20.43798192
126NLK0.43794722
127CCNB10.43513764
128TAOK30.43272877
129EGFR0.42587050
130DYRK1B0.41982558
131OXSR10.41958312
132RPS6KB10.41480701
133MAP2K70.41253025
134PRKG10.40913114
135KDR0.40593069
136MAPK70.40480030
137PRKCE0.40092447
138IRAK10.39720134
139RPS6KL10.38821203
140RPS6KC10.38821203
141PRKACG0.37440844
142PKN10.37207264

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.13407915
2Legionellosis_Homo sapiens_hsa051342.81187468
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.59670814
4Staphylococcus aureus infection_Homo sapiens_hsa051502.58188420
5Malaria_Homo sapiens_hsa051442.48534136
6Graft-versus-host disease_Homo sapiens_hsa053322.45190256
7Allograft rejection_Homo sapiens_hsa053302.42410964
8Pertussis_Homo sapiens_hsa051332.32370674
9Phagosome_Homo sapiens_hsa041452.09166078
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.02586356
11Rheumatoid arthritis_Homo sapiens_hsa053231.99648986
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.98322554
13Measles_Homo sapiens_hsa051621.97621534
14Tuberculosis_Homo sapiens_hsa051521.95285599
15TNF signaling pathway_Homo sapiens_hsa046681.87492663
16Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.83876249
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.79249887
18Viral myocarditis_Homo sapiens_hsa054161.79087444
19Osteoclast differentiation_Homo sapiens_hsa043801.78260757
20Salmonella infection_Homo sapiens_hsa051321.76595140
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.74404056
22Type I diabetes mellitus_Homo sapiens_hsa049401.69776123
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.68577565
24Influenza A_Homo sapiens_hsa051641.61856086
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.60022900
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.58205360
27Toxoplasmosis_Homo sapiens_hsa051451.57925136
28Shigellosis_Homo sapiens_hsa051311.57821421
29Lysosome_Homo sapiens_hsa041421.57591345
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.46700855
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.46060691
32Collecting duct acid secretion_Homo sapiens_hsa049661.43622126
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.42769257
34African trypanosomiasis_Homo sapiens_hsa051431.41445790
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41198985
36Arachidonic acid metabolism_Homo sapiens_hsa005901.39080864
37Apoptosis_Homo sapiens_hsa042101.36880540
38Herpes simplex infection_Homo sapiens_hsa051681.34615984
39Hepatitis B_Homo sapiens_hsa051611.33553655
40Autoimmune thyroid disease_Homo sapiens_hsa053201.32294119
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.28785398
42Complement and coagulation cascades_Homo sapiens_hsa046101.24591165
43Chemokine signaling pathway_Homo sapiens_hsa040621.24203887
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.24136483
45Antigen processing and presentation_Homo sapiens_hsa046121.23057139
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21752453
47Amoebiasis_Homo sapiens_hsa051461.21312271
48Asthma_Homo sapiens_hsa053101.20063355
49Fatty acid elongation_Homo sapiens_hsa000621.18964838
50Hematopoietic cell lineage_Homo sapiens_hsa046401.17300954
51Jak-STAT signaling pathway_Homo sapiens_hsa046301.16153763
52Leukocyte transendothelial migration_Homo sapiens_hsa046701.13070234
53SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08531561
54B cell receptor signaling pathway_Homo sapiens_hsa046621.08454109
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06576225
56Regulation of autophagy_Homo sapiens_hsa041401.02056637
57Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.99560988
58Pancreatic cancer_Homo sapiens_hsa052120.94715806
59Nitrogen metabolism_Homo sapiens_hsa009100.93790464
60Platelet activation_Homo sapiens_hsa046110.92298864
61Chronic myeloid leukemia_Homo sapiens_hsa052200.92189630
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91922372
63Focal adhesion_Homo sapiens_hsa045100.89226690
64Phototransduction_Homo sapiens_hsa047440.88388752
65Caffeine metabolism_Homo sapiens_hsa002320.88386216
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86594770
67Systemic lupus erythematosus_Homo sapiens_hsa053220.85085167
68Hepatitis C_Homo sapiens_hsa051600.82866248
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81617381
70Proteoglycans in cancer_Homo sapiens_hsa052050.81602415
71Steroid biosynthesis_Homo sapiens_hsa001000.81475388
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80516074
73Small cell lung cancer_Homo sapiens_hsa052220.80492358
74Serotonergic synapse_Homo sapiens_hsa047260.80357959
75Adherens junction_Homo sapiens_hsa045200.76449174
76Other glycan degradation_Homo sapiens_hsa005110.75644966
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75462613
78Protein export_Homo sapiens_hsa030600.74504995
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72327473
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71261055
81Linoleic acid metabolism_Homo sapiens_hsa005910.70123199
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67462714
83Peroxisome_Homo sapiens_hsa041460.65425324
84Glutathione metabolism_Homo sapiens_hsa004800.65244784
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.64877287
86Olfactory transduction_Homo sapiens_hsa047400.61966933
87Prolactin signaling pathway_Homo sapiens_hsa049170.60589099
88Salivary secretion_Homo sapiens_hsa049700.60004216
89Ether lipid metabolism_Homo sapiens_hsa005650.57909238
90Prion diseases_Homo sapiens_hsa050200.57214740
91ECM-receptor interaction_Homo sapiens_hsa045120.56750554
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56629045
93Propanoate metabolism_Homo sapiens_hsa006400.56164333
94Renin secretion_Homo sapiens_hsa049240.56036647
95p53 signaling pathway_Homo sapiens_hsa041150.56031644
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.55945951
97TGF-beta signaling pathway_Homo sapiens_hsa043500.54886819
98Renin-angiotensin system_Homo sapiens_hsa046140.53991842
99Butanoate metabolism_Homo sapiens_hsa006500.53957894
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.53676000
101Primary immunodeficiency_Homo sapiens_hsa053400.53166997
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52380729
103Long-term depression_Homo sapiens_hsa047300.52276148
104Melanoma_Homo sapiens_hsa052180.51673588
105Colorectal cancer_Homo sapiens_hsa052100.51600960
106HTLV-I infection_Homo sapiens_hsa051660.50606780
107Viral carcinogenesis_Homo sapiens_hsa052030.50007157
108Acute myeloid leukemia_Homo sapiens_hsa052210.49848463
109MicroRNAs in cancer_Homo sapiens_hsa052060.49548700
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49239684
111Pancreatic secretion_Homo sapiens_hsa049720.48888850
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48518426
113N-Glycan biosynthesis_Homo sapiens_hsa005100.48216864
114Circadian entrainment_Homo sapiens_hsa047130.47209799
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46611284
116Endometrial cancer_Homo sapiens_hsa052130.46575347
117Oxidative phosphorylation_Homo sapiens_hsa001900.46480447
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45359650
119Prostate cancer_Homo sapiens_hsa052150.44475619
120HIF-1 signaling pathway_Homo sapiens_hsa040660.43362656
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43092778
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42877679
123Parkinsons disease_Homo sapiens_hsa050120.42641551
124T cell receptor signaling pathway_Homo sapiens_hsa046600.39538594
125Sulfur metabolism_Homo sapiens_hsa009200.39463285
126Glycerolipid metabolism_Homo sapiens_hsa005610.37177640
127FoxO signaling pathway_Homo sapiens_hsa040680.36685002
128beta-Alanine metabolism_Homo sapiens_hsa004100.35944439
129Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35820893
130PPAR signaling pathway_Homo sapiens_hsa033200.33252680
131Gap junction_Homo sapiens_hsa045400.33022616
132Endocytosis_Homo sapiens_hsa041440.32890363
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31546514
134Epstein-Barr virus infection_Homo sapiens_hsa051690.31529287
135Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31397562
136Thyroid cancer_Homo sapiens_hsa052160.30271210
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29699980
138Vibrio cholerae infection_Homo sapiens_hsa051100.28973017
139Pathways in cancer_Homo sapiens_hsa052000.28608589
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28474097
141Chemical carcinogenesis_Homo sapiens_hsa052040.27316192
142Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27280229
143Glioma_Homo sapiens_hsa052140.26252457
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.24233908
145Insulin resistance_Homo sapiens_hsa049310.23854451

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