SH3BGRL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)6.42751546
2protein neddylation (GO:0045116)5.79274899
3blood coagulation, intrinsic pathway (GO:0007597)5.16056502
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.93172282
5L-phenylalanine catabolic process (GO:0006559)4.93172282
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.86780002
7L-phenylalanine metabolic process (GO:0006558)4.86780002
8neutrophil activation involved in immune response (GO:0002283)4.75309914
9bundle of His cell to Purkinje myocyte communication (GO:0086069)4.74565581
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.65218079
11negative regulation of norepinephrine secretion (GO:0010700)4.64359189
12high-density lipoprotein particle remodeling (GO:0034375)4.60504074
13regulation of lipoprotein metabolic process (GO:0050746)4.57070153
14urea cycle (GO:0000050)4.40772053
15urea metabolic process (GO:0019627)4.40772053
16regulation of platelet aggregation (GO:0090330)4.36110895
17positive regulation of endothelial cell differentiation (GO:0045603)4.32460614
18reverse cholesterol transport (GO:0043691)4.32037210
19regulation of integrin-mediated signaling pathway (GO:2001044)4.30285319
20sulfur amino acid catabolic process (GO:0000098)4.29822917
21aromatic amino acid family catabolic process (GO:0009074)4.29636842
22phospholipid efflux (GO:0033700)4.26509099
23cysteine metabolic process (GO:0006534)4.20751053
24bile acid biosynthetic process (GO:0006699)4.17107015
25regulation of platelet activation (GO:0010543)4.11896000
26kynurenine metabolic process (GO:0070189)4.11596215
27regulation of protein activation cascade (GO:2000257)4.04371833
28alpha-linolenic acid metabolic process (GO:0036109)4.03000834
29nitrogen cycle metabolic process (GO:0071941)3.95626264
30protein carboxylation (GO:0018214)3.94903117
31peptidyl-glutamic acid carboxylation (GO:0017187)3.94903117
32negative regulation of heart rate (GO:0010459)3.92902865
33negative regulation of sterol transport (GO:0032372)3.91501816
34negative regulation of cholesterol transport (GO:0032375)3.91501816
35negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.87286114
36regulation of complement activation (GO:0030449)3.86214382
37indole-containing compound catabolic process (GO:0042436)3.85831993
38indolalkylamine catabolic process (GO:0046218)3.85831993
39tryptophan catabolic process (GO:0006569)3.85831993
40negative regulation of fibrinolysis (GO:0051918)3.81579375
41protein-lipid complex remodeling (GO:0034368)3.79468878
42macromolecular complex remodeling (GO:0034367)3.79468878
43plasma lipoprotein particle remodeling (GO:0034369)3.79468878
44platelet aggregation (GO:0070527)3.74019212
45regulation of cholesterol esterification (GO:0010872)3.72908995
46tryptophan metabolic process (GO:0006568)3.70412186
47cholesterol efflux (GO:0033344)3.69472514
48homocysteine metabolic process (GO:0050667)3.67425389
49bile acid metabolic process (GO:0008206)3.67067267
50negative regulation of platelet activation (GO:0010544)3.63349199
51bile acid and bile salt transport (GO:0015721)3.59841522
52regulation of cholesterol homeostasis (GO:2000188)3.53839677
53plasma lipoprotein particle clearance (GO:0034381)3.53662922
54complement activation, alternative pathway (GO:0006957)3.52471036
55negative regulation of homotypic cell-cell adhesion (GO:0034111)3.47838863
56serine family amino acid catabolic process (GO:0009071)3.47385272
57fibrinolysis (GO:0042730)3.45870272
58regulation of fibrinolysis (GO:0051917)3.45515310
59fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.44102683
60positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.43752500
61leukocyte migration involved in inflammatory response (GO:0002523)3.43117163
62phospholipid homeostasis (GO:0055091)3.42413723
63negative regulation of appetite (GO:0032099)3.42361214
64negative regulation of response to food (GO:0032096)3.42361214
65adenosine receptor signaling pathway (GO:0001973)3.41555671
66negative regulation of protein activation cascade (GO:2000258)3.39972050
67desmosome organization (GO:0002934)3.39373019
68cellular modified amino acid catabolic process (GO:0042219)3.38505568
69lysine metabolic process (GO:0006553)3.37151695
70lysine catabolic process (GO:0006554)3.37151695
71regulation of triglyceride catabolic process (GO:0010896)3.34097648
72dicarboxylic acid biosynthetic process (GO:0043650)3.32892565
73positive regulation of cAMP-mediated signaling (GO:0043950)3.31398808
74amino-acid betaine metabolic process (GO:0006577)3.31313159
75glyoxylate metabolic process (GO:0046487)3.30674663
76regulation of Golgi to plasma membrane protein transport (GO:0042996)3.29186529
77negative regulation of catecholamine secretion (GO:0033604)3.28727502
78glutamate metabolic process (GO:0006536)3.27784401
79triglyceride homeostasis (GO:0070328)3.25024057
80acylglycerol homeostasis (GO:0055090)3.25024057
81tyrosine metabolic process (GO:0006570)3.22775170
82negative regulation of protein localization to cell surface (GO:2000009)3.22256178
83aromatic amino acid family metabolic process (GO:0009072)3.21632014
84regulation of bile acid biosynthetic process (GO:0070857)3.20171214
85platelet degranulation (GO:0002576)3.20157757
86positive regulation of blood coagulation (GO:0030194)3.16061949
87positive regulation of hemostasis (GO:1900048)3.16061949
88positive regulation of mast cell activation (GO:0033005)3.14075714
89cellular glucuronidation (GO:0052695)3.11448865
90regulation of female receptivity (GO:0045924)3.10876540
91drug catabolic process (GO:0042737)3.10221670
92lipoxygenase pathway (GO:0019372)3.09629120
93glomerular visceral epithelial cell development (GO:0072015)3.07858075
94plasma lipoprotein particle assembly (GO:0034377)3.05840152
95regulation of protein glycosylation (GO:0060049)3.05358589
96lipoprotein metabolic process (GO:0042157)3.04139583
97alpha-amino acid catabolic process (GO:1901606)3.04010838
98angiogenesis involved in wound healing (GO:0060055)3.03864407
99negative regulation of heart contraction (GO:0045822)3.02683576
100regulation of endothelial cell differentiation (GO:0045601)3.02446322
101negative regulation of complement activation (GO:0045916)3.00969726
102tonic smooth muscle contraction (GO:0014820)2.99985738
103regulation of cholesterol biosynthetic process (GO:0045540)2.99277327
104beta-amyloid metabolic process (GO:0050435)2.98612735
105arginine metabolic process (GO:0006525)2.98581999
106positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.98188128
107sterol transport (GO:0015918)2.96573618
108cholesterol transport (GO:0030301)2.96573618
109macroautophagy (GO:0016236)2.96221845
110positive regulation of lipid catabolic process (GO:0050996)2.94706756
111benzene-containing compound metabolic process (GO:0042537)2.93114242
112low-density lipoprotein particle remodeling (GO:0034374)2.92814996
113regulation of norepinephrine secretion (GO:0014061)2.92530361
114regulation of macrophage derived foam cell differentiation (GO:0010743)2.91628577
115negative regulation of thymocyte apoptotic process (GO:0070244)2.91140706
116positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.91064072
117negative regulation of coagulation (GO:0050819)2.90660201
118glucuronate metabolic process (GO:0019585)2.90281467
119uronic acid metabolic process (GO:0006063)2.90281467
120cell adhesion mediated by integrin (GO:0033627)2.89454490
121plasma lipoprotein particle organization (GO:0071827)2.88387730
122dopamine transport (GO:0015872)2.88239982
123ethanol oxidation (GO:0006069)2.88064534
124long-chain fatty acid biosynthetic process (GO:0042759)2.88031182
125protein-lipid complex assembly (GO:0065005)2.88009439
126negative regulation of blood coagulation (GO:0030195)2.87896100
127negative regulation of hemostasis (GO:1900047)2.87896100
128regulation of clathrin-mediated endocytosis (GO:2000369)2.86857382
129cellular amino acid catabolic process (GO:0009063)2.86528410
130positive regulation of coagulation (GO:0050820)2.86433498
131intestinal cholesterol absorption (GO:0030299)2.83549327
132positive regulation of cardiac muscle hypertrophy (GO:0010613)2.83384668
133positive regulation of muscle hypertrophy (GO:0014742)2.83384668
134regulation of hemostasis (GO:1900046)2.83336604
135regulation of blood coagulation (GO:0030193)2.83336604
136regulation of response to food (GO:0032095)2.82138721
137sterol homeostasis (GO:0055092)2.80733897
138cholesterol homeostasis (GO:0042632)2.80337634
139protein-lipid complex subunit organization (GO:0071825)2.79160376
140fatty acid elongation (GO:0030497)2.76757083
141hemidesmosome assembly (GO:0031581)2.75133432
142positive regulation of neurotransmitter secretion (GO:0001956)2.74660703
143acute-phase response (GO:0006953)2.72042827
144aldehyde catabolic process (GO:0046185)2.71892582
145indolalkylamine metabolic process (GO:0006586)2.71862494
146positive regulation of systemic arterial blood pressure (GO:0003084)2.70706256
147relaxation of smooth muscle (GO:0044557)2.70379826
148G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.70190874
149exogenous drug catabolic process (GO:0042738)2.70051463
150auditory receptor cell differentiation (GO:0042491)2.69668879
151platelet activation (GO:0030168)2.69644940
152complement activation, classical pathway (GO:0006958)2.69414460
153regulation of cAMP-dependent protein kinase activity (GO:2000479)2.68204542
154nitric oxide mediated signal transduction (GO:0007263)2.68181967
155autophagic vacuole fusion (GO:0000046)2.67849060
156coenzyme catabolic process (GO:0009109)2.67558587
157glomerular epithelial cell development (GO:0072310)2.67389934
158cellular ketone body metabolic process (GO:0046950)2.66261361
159pyrimidine nucleoside catabolic process (GO:0046135)2.65956045
160positive regulation of receptor recycling (GO:0001921)2.63632177
161xenobiotic catabolic process (GO:0042178)2.61543145
162regulation of coagulation (GO:0050818)2.60682355
163termination of G-protein coupled receptor signaling pathway (GO:0038032)2.58455523
164relaxation of muscle (GO:0090075)2.57697801
165negative regulation of blood circulation (GO:1903523)2.56167942
166purinergic nucleotide receptor signaling pathway (GO:0035590)2.54008191
167female mating behavior (GO:0060180)2.53162484
168neutrophil activation (GO:0042119)2.53083421
169negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.52485101
170regulation of inositol phosphate biosynthetic process (GO:0010919)2.52022320
171homotypic cell-cell adhesion (GO:0034109)2.51400612
172positive regulation of Rho protein signal transduction (GO:0035025)2.50662102
173fusion of sperm to egg plasma membrane (GO:0007342)2.50267628
174termination of signal transduction (GO:0023021)2.49450326
175regulation of integrin activation (GO:0033623)2.46439505
176water transport (GO:0006833)2.45802433
177positive regulation of glycolytic process (GO:0045821)2.43408205
178monoamine transport (GO:0015844)2.43013747
179positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.40855736
180positive regulation of neurotransmitter transport (GO:0051590)2.39170084
181negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.38878973
182negative regulation of wound healing (GO:0061045)2.37839074
183megakaryocyte development (GO:0035855)2.36618147
184negative regulation of neurotransmitter transport (GO:0051589)2.36556732
185mesodermal cell differentiation (GO:0048333)2.36537618
186artery smooth muscle contraction (GO:0014824)2.36030528
187positive regulation of synaptic transmission, GABAergic (GO:0032230)2.33764135

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.80438045
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.93774826
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.67070127
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.32313609
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.97967869
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.29298061
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.25591541
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.23630154
9GBX2_23144817_ChIP-Seq_PC3_Human3.13769902
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.71430638
11* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.56130881
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.47594987
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.45358610
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.44606785
15TAF15_26573619_Chip-Seq_HEK293_Human2.34359437
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.24088719
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21841890
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.04623415
19LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.99560854
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92464098
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.82991163
22* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.80397836
23ZNF263_19887448_ChIP-Seq_K562_Human1.79912762
24* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.76900847
25SMAD4_21799915_ChIP-Seq_A2780_Human1.75755055
26VDR_22108803_ChIP-Seq_LS180_Human1.74661859
27SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.74294720
28SOX2_20726797_ChIP-Seq_SW620_Human1.70707778
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68876270
30P300_19829295_ChIP-Seq_ESCs_Human1.67335132
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.66025600
32GATA1_19941826_ChIP-Seq_K562_Human1.65858156
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61739586
34GATA4_25053715_ChIP-Seq_YYC3_Human1.59538233
35* GATA2_19941826_ChIP-Seq_K562_Human1.58674969
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58367367
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.56813028
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.55228386
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55201625
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.54831733
41EZH2_22144423_ChIP-Seq_EOC_Human1.54134884
42* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53563756
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.53255642
44FOXA2_19822575_ChIP-Seq_HepG2_Human1.53000944
45CDX2_20551321_ChIP-Seq_CACO-2_Human1.52917303
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.51403445
47SCL_19346495_ChIP-Seq_HPC-7_Human1.49594204
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.47209903
49CLOCK_20551151_ChIP-Seq_293T_Human1.44201595
50AR_25329375_ChIP-Seq_VCAP_Human1.43789205
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42853939
52* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.41263699
53TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.39106051
54IGF1R_20145208_ChIP-Seq_DFB_Human1.39084813
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37841639
56NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.35784014
57EWS_26573619_Chip-Seq_HEK293_Human1.35737586
58STAT3_23295773_ChIP-Seq_U87_Human1.35657537
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35391045
60ESR1_15608294_ChIP-ChIP_MCF-7_Human1.35344193
61PPAR_26484153_Chip-Seq_NCI-H1993_Human1.34461189
62* GATA6_25053715_ChIP-Seq_YYC3_Human1.33336851
63P53_22387025_ChIP-Seq_ESCs_Mouse1.32832245
64BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.31208849
65NANOG_18555785_Chip-Seq_ESCs_Mouse1.31098948
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30712503
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.29384694
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.28923113
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.28895276
70FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.28842973
71ER_23166858_ChIP-Seq_MCF-7_Human1.28755102
72NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28732643
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25982472
74TCF4_23295773_ChIP-Seq_U87_Human1.25791453
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.25596048
76FUS_26573619_Chip-Seq_HEK293_Human1.25545535
77SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.25426915
78SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.25426915
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24140087
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21218812
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20478803
82AHR_22903824_ChIP-Seq_MCF-7_Human1.19198114
83E2F1_18555785_Chip-Seq_ESCs_Mouse1.19084956
84TCF4_18268006_ChIP-ChIP_LS174T_Human1.18663925
85SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18240892
86FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18093710
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16864323
88NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16864323
89CMYC_18555785_Chip-Seq_ESCs_Mouse1.15944145
90SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13890334
91* HNF4A_19822575_ChIP-Seq_HepG2_Human1.13670565
92SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13006230
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12479903
94PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12045033
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11258752
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10974798
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10148072
98ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10060700
99NANOG_19829295_ChIP-Seq_ESCs_Human1.09495509
100SOX2_19829295_ChIP-Seq_ESCs_Human1.09495509
101AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.07946988
102GATA3_24758297_ChIP-Seq_MCF-7_Human1.07897005
103GATA1_22025678_ChIP-Seq_K562_Human1.07832541
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07305644
105SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.06979821
106CJUN_26792858_Chip-Seq_BT549_Human1.06858442
107BCAT_22108803_ChIP-Seq_LS180_Human1.06533204
108TAL1_26923725_Chip-Seq_HPCs_Mouse1.06391611
109LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06223572
110SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06192345
111TBL1_22424771_ChIP-Seq_293T_Human1.04391861
112KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.03956336
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03204697
114* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02932382
115ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02111549
116HTT_18923047_ChIP-ChIP_STHdh_Human1.00307920
117NFE2_27457419_Chip-Seq_LIVER_Mouse0.99667120
118GATA2_21666600_ChIP-Seq_HMVEC_Human0.99108403
119EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98854063
120HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98775729
121TP63_23658742_ChIP-Seq_EP156T_Human0.98622523
122STAT3_18555785_Chip-Seq_ESCs_Mouse0.98544472
123SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98051222
124FLI1_21867929_ChIP-Seq_TH2_Mouse0.97791936
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97704346
126TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97669549
127OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97535871
128CRX_20693478_ChIP-Seq_RETINA_Mouse0.97534683
129* SOX2_21211035_ChIP-Seq_LN229_Gbm0.97239610
130PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97012365
131ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96603009
132FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.96474135
133CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96462982
134LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95366468
135EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95203282
136* ELK4_26923725_Chip-Seq_MESODERM_Mouse0.95075089
137* RNF2_27304074_Chip-Seq_NSC_Mouse0.94915854
138AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94878758
139ATF3_27146783_Chip-Seq_COLON_Human0.94855098
140FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94778911
141NFYA_21822215_ChIP-Seq_K562_Human0.94580585
142GATA1_19941827_ChIP-Seq_MEL_Mouse0.94295740
143CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94179724
144EGR1_19032775_ChIP-ChIP_M12_Human0.91763483
145TRIM28_21343339_ChIP-Seq_HEK293_Human0.91420989
146KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91216665
147RACK7_27058665_Chip-Seq_MCF-7_Human0.91192388
148TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86662158
149ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.86619053
150P63_26484246_Chip-Seq_KERATINOCYTES_Human0.86526049
151THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86145716
152IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.84133214
153MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.83112869
154RXR_22108803_ChIP-Seq_LS180_Human0.82639394
155* CDX2_22108803_ChIP-Seq_LS180_Human0.81656796
156* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.81445247
157FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81435392
158KLF5_25053715_ChIP-Seq_YYC3_Human0.81435099
159RUNX1_27514584_Chip-Seq_MCF-7_Human0.79818485
160ARNT_22903824_ChIP-Seq_MCF-7_Human0.78368097
161STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.78142478
162JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77706025
163TCF4_22108803_ChIP-Seq_LS180_Human0.75618213
164ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.74692796
165JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74490455
166NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.72596020
167FOXA1_25552417_ChIP-Seq_VCAP_Human0.71917671
168KDM2B_26808549_Chip-Seq_K562_Human0.71072546
169PIAS1_25552417_ChIP-Seq_VCAP_Human0.70795909
170GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.67433341
171TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65053755
172SMAD4_21741376_ChIP-Seq_HESCs_Human0.64569538
173SMAD3_21741376_ChIP-Seq_HESCs_Human0.63230994
174* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.63209207

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology7.23803330
2MP0002139_abnormal_hepatobiliary_system5.84622455
3MP0005360_urolithiasis5.35387620
4MP0005085_abnormal_gallbladder_physiolo4.64428780
5MP0010234_abnormal_vibrissa_follicle4.40208930
6MP0005365_abnormal_bile_salt4.04910364
7MP0008875_abnormal_xenobiotic_pharmacok3.51424569
8MP0005083_abnormal_biliary_tract3.21127741
9MP0009780_abnormal_chondrocyte_physiolo2.98755498
10MP0003011_delayed_dark_adaptation2.89128533
11MP0009840_abnormal_foam_cell2.88734080
12MP0000465_gastrointestinal_hemorrhage2.68037341
13MP0003806_abnormal_nucleotide_metabolis2.64237250
14MP0002796_impaired_skin_barrier2.59399000
15MP0010329_abnormal_lipoprotein_level2.53117728
16MP0001666_abnormal_nutrient_absorption2.50723950
17MP0003705_abnormal_hypodermis_morpholog2.39763609
18MP0003252_abnormal_bile_duct2.38897307
19MP0003724_increased_susceptibility_to2.32014068
20MP0003191_abnormal_cellular_cholesterol2.30653418
21MP0004019_abnormal_vitamin_homeostasis2.26710297
22MP0002735_abnormal_chemical_nociception2.18020288
23MP0004510_myositis2.16406991
24MP0008872_abnormal_physiological_respon2.09152375
25MP0002254_reproductive_system_inflammat2.06275779
26MP0002736_abnormal_nociception_after2.03013005
27MP0005332_abnormal_amino_acid2.02298994
28MP0000230_abnormal_systemic_arterial2.02071499
29MP0003787_abnormal_imprinting1.99290711
30MP0004147_increased_porphyrin_level1.94675579
31MP0001968_abnormal_touch/_nociception1.92108174
32MP0003195_calcinosis1.89130809
33MP0000604_amyloidosis1.88645838
34MP0004858_abnormal_nervous_system1.88358184
35MP0005084_abnormal_gallbladder_morpholo1.83914471
36MP0008004_abnormal_stomach_pH1.83646765
37MP0003879_abnormal_hair_cell1.82253913
38MP0005646_abnormal_pituitary_gland1.79707483
39MP0003122_maternal_imprinting1.77387463
40MP0008775_abnormal_heart_ventricle1.72866692
41MP0004084_abnormal_cardiac_muscle1.67006550
42MP0005451_abnormal_body_composition1.60943546
43MP0004215_abnormal_myocardial_fiber1.51588032
44MP0001765_abnormal_ion_homeostasis1.51223454
45MP0000609_abnormal_liver_physiology1.49348674
46MP0003453_abnormal_keratinocyte_physiol1.47226293
47MP0002118_abnormal_lipid_homeostasis1.43522518
48MP0003329_amyloid_beta_deposits1.41641624
49MP0005409_darkened_coat_color1.40931652
50MP0008877_abnormal_DNA_methylation1.40852307
51MP0004947_skin_inflammation1.37694400
52MP0005319_abnormal_enzyme/_coenzyme1.36732024
53MP0006054_spinal_hemorrhage1.36368509
54MP0005501_abnormal_skin_physiology1.35558801
55MP0010678_abnormal_skin_adnexa1.33832276
56MP0004043_abnormal_pH_regulation1.32560833
57MP0004782_abnormal_surfactant_physiolog1.31141308
58MP0003868_abnormal_feces_composition1.30758259
59MP0000537_abnormal_urethra_morphology1.28461256
60MP0002090_abnormal_vision1.26350902
61MP0002909_abnormal_adrenal_gland1.26084091
62MP0005551_abnormal_eye_electrophysiolog1.25613818
63MP0009764_decreased_sensitivity_to1.23984524
64MP0000427_abnormal_hair_cycle1.23307003
65MP0002132_abnormal_respiratory_system1.23123138
66MP0009643_abnormal_urine_homeostasis1.21775054
67MP0004264_abnormal_extraembryonic_tissu1.20300012
68MP0010352_gastrointestinal_tract_polyps1.18890046
69MP0004036_abnormal_muscle_relaxation1.17494451
70MP0005410_abnormal_fertilization1.16907736
71MP0006276_abnormal_autonomic_nervous1.16746527
72MP0003300_gastrointestinal_ulcer1.14904926
73MP0010771_integument_phenotype1.14336631
74MP0001756_abnormal_urination1.13430232
75MP0000579_abnormal_nail_morphology1.13303647
76MP0004484_altered_response_of1.10589211
77MP0009697_abnormal_copulation1.10510953
78MP0005167_abnormal_blood-brain_barrier1.09605167
79MP0005535_abnormal_body_temperature1.08478865
80MP0002733_abnormal_thermal_nociception1.06718490
81MP0003656_abnormal_erythrocyte_physiolo1.06174442
82MP0009046_muscle_twitch1.05698508
83MP0002078_abnormal_glucose_homeostasis1.03807464
84MP0005166_decreased_susceptibility_to1.01807399
85MP0003718_maternal_effect1.01662180
86MP0005058_abnormal_lysosome_morphology1.01509153
87MP0001216_abnormal_epidermal_layer1.01408563
88MP0009642_abnormal_blood_homeostasis1.00393374
89MP0005220_abnormal_exocrine_pancreas0.98825044
90MP0005647_abnormal_sex_gland0.97663317
91MP0004130_abnormal_muscle_cell0.96636086
92MP0003566_abnormal_cell_adhesion0.96304570
93MP0001764_abnormal_homeostasis0.95687426
94MP0000538_abnormal_urinary_bladder0.95515688
95MP0002138_abnormal_hepatobiliary_system0.94293188
96MP0005584_abnormal_enzyme/coenzyme_acti0.94280723
97MP0004085_abnormal_heartbeat0.91688012
98MP0005448_abnormal_energy_balance0.91502971
99MP0005174_abnormal_tail_pigmentation0.90008409
100MP0001879_abnormal_lymphatic_vessel0.89810446
101MP0000343_altered_response_to0.88498576
102MP0001485_abnormal_pinna_reflex0.88245175
103MP0004859_abnormal_synaptic_plasticity0.87613175
104MP0009745_abnormal_behavioral_response0.87460012
105MP0002272_abnormal_nervous_system0.87132826
106MP0003186_abnormal_redox_activity0.86711255
107MP0010386_abnormal_urinary_bladder0.86038323
108MP0002102_abnormal_ear_morphology0.85658699
109MP0001501_abnormal_sleep_pattern0.84712825
110MP0002734_abnormal_mechanical_nocicepti0.84060797
111MP0003953_abnormal_hormone_level0.83087269
112MP0005670_abnormal_white_adipose0.82972710
113MP0002060_abnormal_skin_morphology0.82351324
114MP0003880_abnormal_central_pattern0.82189212
115MP0010155_abnormal_intestine_physiology0.81597206
116MP0003941_abnormal_skin_development0.81593546
117MP0005381_digestive/alimentary_phenotyp0.81167598
118MP0001851_eye_inflammation0.81066757
119MP0002136_abnormal_kidney_physiology0.80725444
120MP0002693_abnormal_pancreas_physiology0.80246498
121MP0001661_extended_life_span0.79541116
122MP0002064_seizures0.78491446
123MP0000647_abnormal_sebaceous_gland0.76984760
124MP0003183_abnormal_peptide_metabolism0.76717450
125MP0004270_analgesia0.75852764
126MP0002876_abnormal_thyroid_physiology0.75718448
127MP0001984_abnormal_olfaction0.75496803
128MP0002098_abnormal_vibrissa_morphology0.73491243
129MP0003303_peritoneal_inflammation0.72635952
130MP0002557_abnormal_social/conspecific_i0.72110089
131MP0003866_abnormal_defecation0.71826491
132MP0005187_abnormal_penis_morphology0.71358766
133MP0001486_abnormal_startle_reflex0.71208852
134MP0005275_abnormal_skin_tensile0.71186676
135MP0001970_abnormal_pain_threshold0.69092349
136MP0000377_abnormal_hair_follicle0.68416104
137MP0004142_abnormal_muscle_tone0.68363871
138MP0005023_abnormal_wound_healing0.66985998
139MP0003075_altered_response_to0.66826678
140MP0005636_abnormal_mineral_homeostasis0.66498386
141MP0010368_abnormal_lymphatic_system0.66489675
142MP0005408_hypopigmentation0.64551930
143MP0000598_abnormal_liver_morphology0.63687463
144MP0008260_abnormal_autophagy0.62164937
145MP0005248_abnormal_Harderian_gland0.61113109
146MP0001324_abnormal_eye_pigmentation0.59347152
147MP0008469_abnormal_protein_level0.57168238
148MP0005253_abnormal_eye_physiology0.56735503
149MP0001664_abnormal_digestion0.56433038
150MP0001663_abnormal_digestive_system0.55464317
151MP0003638_abnormal_response/metabolism_0.55382314
152MP0002229_neurodegeneration0.54999295
153MP0009053_abnormal_anal_canal0.54918474
154MP0004185_abnormal_adipocyte_glucose0.54346042
155MP0001881_abnormal_mammary_gland0.53722773
156MP0000383_abnormal_hair_follicle0.53393611
157MP0009765_abnormal_xenobiotic_induced0.53136153
158MP0005197_abnormal_uvea_morphology0.52602377
159MP0003172_abnormal_lysosome_physiology0.52180266
160MP0001191_abnormal_skin_condition0.51531679

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)9.11647222
2Increased mean platelet volume (HP:0011877)8.78341728
3Menorrhagia (HP:0000132)8.52925911
4Petechiae (HP:0000967)8.06025649
5Abnormal platelet volume (HP:0011876)8.04091189
6Purpura (HP:0000979)6.92988702
7Gingival bleeding (HP:0000225)5.91905636
8Epistaxis (HP:0000421)5.63511942
9Deep venous thrombosis (HP:0002625)5.55881813
10Intrahepatic cholestasis (HP:0001406)5.55005615
11Abnormality of monocarboxylic acid metabolism (HP:0010996)5.38055045
12Xanthomatosis (HP:0000991)4.67826844
13Acanthocytosis (HP:0001927)4.55906670
14Abnormality of aromatic amino acid family metabolism (HP:0004338)4.49604148
15Hypobetalipoproteinemia (HP:0003563)4.32126992
16Abnormal platelet function (HP:0011869)4.28383947
17Impaired platelet aggregation (HP:0003540)4.28383947
18Poikilocytosis (HP:0004447)4.25599410
19Abnormality of glutamine family amino acid metabolism (HP:0010902)3.97810554
20Complement deficiency (HP:0004431)3.76622453
21Epidermoid cyst (HP:0200040)3.69385794
22Right ventricular cardiomyopathy (HP:0011663)3.62003965
23Prolonged partial thromboplastin time (HP:0003645)3.57201013
24Fat malabsorption (HP:0002630)3.51748472
25Focal segmental glomerulosclerosis (HP:0000097)3.49340283
26Hypolipoproteinemia (HP:0010981)3.47890377
27Pigmentary retinal degeneration (HP:0001146)3.27148730
28Papillary thyroid carcinoma (HP:0002895)3.23945162
29Hyperlipoproteinemia (HP:0010980)3.22963718
30Hypoalphalipoproteinemia (HP:0003233)3.21947373
31Hyperammonemia (HP:0001987)3.21850464
32Glomerulonephritis (HP:0000099)3.19950493
33Spontaneous hematomas (HP:0007420)3.18878967
34Dyschromatopsia (HP:0007641)3.12195056
35Conjugated hyperbilirubinemia (HP:0002908)3.07174728
36Glomerulosclerosis (HP:0000096)3.03023647
37Hypoglycemic coma (HP:0001325)2.96887669
38Vascular calcification (HP:0004934)2.95560297
39Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.95522346
40Abnormality of sulfur amino acid metabolism (HP:0004339)2.92320226
41Congenital stationary night blindness (HP:0007642)2.87247347
42Abnormality of the common coagulation pathway (HP:0010990)2.85567483
43Abnormality of proline metabolism (HP:0010907)2.85116917
44Hydroxyprolinuria (HP:0003080)2.85116917
45Conjunctival telangiectasia (HP:0000524)2.85007430
46Ulnar claw (HP:0001178)2.84518292
47Esophageal varix (HP:0002040)2.82902180
48Abnormality of complement system (HP:0005339)2.81428972
49Chorioretinal atrophy (HP:0000533)2.79977555
50Nephritis (HP:0000123)2.79057831
51Cholecystitis (HP:0001082)2.77553189
52Abnormal gallbladder physiology (HP:0012438)2.77553189
53Malnutrition (HP:0004395)2.77411891
54Biliary tract neoplasm (HP:0100574)2.77278723
55Thyroid carcinoma (HP:0002890)2.75092295
56Abnormal pupillary function (HP:0007686)2.74479217
57Hypercholesterolemia (HP:0003124)2.72308246
58Abnormality of pyrimidine metabolism (HP:0004353)2.69504021
59Steatorrhea (HP:0002570)2.67728851
60Joint hemorrhage (HP:0005261)2.62606859
61Sensorimotor neuropathy (HP:0007141)2.58984445
62Increased density of long bones (HP:0006392)2.56699800
63Hyperglycinemia (HP:0002154)2.56333465
64Axonal loss (HP:0003447)2.52600354
65Cardiovascular calcification (HP:0011915)2.52511604
66Myocardial infarction (HP:0001658)2.50195916
67Termporal pattern (HP:0011008)2.50139248
68Insidious onset (HP:0003587)2.50139248
69Hyperthyroidism (HP:0000836)2.49662682
70Polyphagia (HP:0002591)2.47536376
71Systemic lupus erythematosus (HP:0002725)2.47165110
72Ventricular fibrillation (HP:0001663)2.44144075
73Abnormality of the vasculature of the conjunctiva (HP:0008054)2.43265958
74Abnormality of the intrinsic pathway (HP:0010989)2.42422524
75Hyperglycinuria (HP:0003108)2.41316038
76Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.41172769
77Cone-rod dystrophy (HP:0000548)2.35760112
78Abnormality of aspartate family amino acid metabolism (HP:0010899)2.35252812
79Abnormality of nucleobase metabolism (HP:0010932)2.34840744
80Decreased central vision (HP:0007663)2.32607715
81Bruising susceptibility (HP:0000978)2.30244166
82Spastic diplegia (HP:0001264)2.28369438
83Hypoglycemic seizures (HP:0002173)2.27680077
84Central scotoma (HP:0000603)2.27506550
85Hepatocellular carcinoma (HP:0001402)2.25983442
86Increased CSF protein (HP:0002922)2.25757541
87Abnormal biliary tract morphology (HP:0012440)2.25287506
88Abnormal auditory evoked potentials (HP:0006958)2.23728352
89Testicular neoplasm (HP:0010788)2.23197649
90Abnormality of methionine metabolism (HP:0010901)2.22958882
91Abnormality of serine family amino acid metabolism (HP:0010894)2.22645592
92Abnormality of glycine metabolism (HP:0010895)2.22645592
93Abnormality of the heme biosynthetic pathway (HP:0010472)2.22605246
94Abnormality of lateral ventricle (HP:0030047)2.21764604
95Mesangial abnormality (HP:0001966)2.20536450
96Thyroid-stimulating hormone excess (HP:0002925)2.19265909
97Abnormality of purine metabolism (HP:0004352)2.17509106
98Hypomagnesemia (HP:0002917)2.17171543
99Neonatal onset (HP:0003623)2.16741695
100Skin nodule (HP:0200036)2.14884307
101Febrile seizures (HP:0002373)2.14738501
102Abnormality of the lower motor neuron (HP:0002366)2.14432246
103Cholelithiasis (HP:0001081)2.14302383
104Recurrent gram-negative bacterial infections (HP:0005420)2.13388403
105Plantar hyperkeratosis (HP:0007556)2.12279065
106Abnormality of the Achilles tendon (HP:0005109)2.09594784
107Upper motor neuron abnormality (HP:0002127)2.09456292
108Male infertility (HP:0003251)2.07100874
109Tongue fasciculations (HP:0001308)2.07028736
110Ketosis (HP:0001946)2.06901932
111Proximal tubulopathy (HP:0000114)2.05561205
112Onycholysis (HP:0001806)2.04117697
113Abnormal gallbladder morphology (HP:0012437)2.03540539
114Hyperactive renin-angiotensin system (HP:0000841)2.03406158
115Retinal atrophy (HP:0001105)2.01889817
116Gout (HP:0001997)2.00972840
117Abnormal ciliary motility (HP:0012262)2.00292324
118Hypophosphatemic rickets (HP:0004912)1.98790002
119Interstitial pulmonary disease (HP:0006530)1.98539196
120Peripheral demyelination (HP:0011096)1.97087353
121Bony spicule pigmentary retinopathy (HP:0007737)1.94525405
122Congenital sensorineural hearing impairment (HP:0008527)1.93161516
123Tetraparesis (HP:0002273)1.91883580
124Curly hair (HP:0002212)1.91547212
125Paralysis (HP:0003470)1.90247427
126Spontaneous abortion (HP:0005268)1.90109539
127Amyloidosis (HP:0011034)1.89856181
128Hypothermia (HP:0002045)1.89542560
129Segmental peripheral demyelination/remyelination (HP:0003481)1.89375431
130Abnormality of magnesium homeostasis (HP:0004921)1.88787970
131Fragile nails (HP:0001808)1.87137835
132Joint swelling (HP:0001386)1.84797234
133Generalized aminoaciduria (HP:0002909)1.83767298
134Hyperbilirubinemia (HP:0002904)1.83502228
135Status epilepticus (HP:0002133)1.82673458
136Macular degeneration (HP:0000608)1.81163606
137Abnormal respiratory epithelium morphology (HP:0012253)1.80877769
138Abnormal respiratory motile cilium morphology (HP:0005938)1.80877769
139Hand muscle atrophy (HP:0009130)1.80799841
140Upper limb muscle weakness (HP:0003484)1.80708580
141Increased cerebral lipofuscin (HP:0011813)1.80479322
142Mitral stenosis (HP:0001718)1.79642748
143Muscle fibrillation (HP:0010546)1.79613918
144Abnormality of renin-angiotensin system (HP:0000847)1.78815072
145Ileus (HP:0002595)1.78718142
146Decreased circulating renin level (HP:0003351)1.78142943
147Palmoplantar hyperkeratosis (HP:0000972)1.77624508
148Dynein arm defect of respiratory motile cilia (HP:0012255)1.77026907
149Absent/shortened dynein arms (HP:0200106)1.77026907
150Transitional cell carcinoma of the bladder (HP:0006740)1.76619475
151Metabolic alkalosis (HP:0200114)1.76605229
152Pancreatic islet-cell hyperplasia (HP:0004510)1.76417266
153Hyperinsulinemic hypoglycemia (HP:0000825)1.75462260
154Abnormality of chloride homeostasis (HP:0011422)1.75262285
155Hemorrhage of the eye (HP:0011885)1.74503407
156Abolished electroretinogram (ERG) (HP:0000550)1.74182398
157Irritability (HP:0000737)1.72893617
158Goiter (HP:0000853)1.72674059
159Hyperglycemia (HP:0003074)1.72404336
160Congenital ichthyosiform erythroderma (HP:0007431)1.71942012
161Potter facies (HP:0002009)1.70700776
162Facial shape deformation (HP:0011334)1.70700776
163Action tremor (HP:0002345)1.70033015
164Corneal erosion (HP:0200020)1.69784628
165Symptomatic seizures (HP:0011145)1.67256283
166Abnormal eating behavior (HP:0100738)1.65993030
167Rhinitis (HP:0012384)1.64381060
168Nausea (HP:0002018)1.63504006
169Glycosuria (HP:0003076)1.61804951
170Abnormality of urine glucose concentration (HP:0011016)1.61804951
171Abnormality of calcium-phosphate metabolism (HP:0100530)1.59947016
172Bladder carcinoma (HP:0002862)1.59528681
173Bladder neoplasm (HP:0009725)1.59528681
174Abnormality of endocrine pancreas physiology (HP:0012093)1.59515517
175Abnormality of the pancreatic islet cells (HP:0006476)1.59515517
176Renal tubular acidosis (HP:0001947)1.58365935
177Abnormal respiratory motile cilium physiology (HP:0012261)1.58317878
178Arthropathy (HP:0003040)1.56064381
179Abnormality of vitamin metabolism (HP:0100508)1.55846991
180Fair hair (HP:0002286)1.52652497
181Ketoacidosis (HP:0001993)1.52092773
182Abnormal pancreas size (HP:0012094)1.51790270
183Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.51768082
184Abnormality of vitamin B metabolism (HP:0004340)1.51731618
185Rickets (HP:0002748)1.50939784
186Infertility (HP:0000789)1.50402180

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK23.63573707
2FRK3.37888300
3MAP3K93.24071385
4EPHA23.08313288
5MST42.97109367
6ACVR1B2.92200839
7KSR22.88236391
8MAP3K22.85497933
9TNIK2.71185675
10MYLK2.61797003
11EIF2AK12.59572746
12FER2.52393910
13MST1R2.50311057
14STK242.26682184
15ERBB42.16756453
16PTK2B2.16297333
17TRIM282.02837539
18LATS11.96792054
19ERN11.90826784
20TEC1.88237356
21PIK3CG1.87013323
22LATS21.81791455
23PNCK1.78616189
24PLK21.63386057
25NTRK11.62553566
26PBK1.62551563
27ARAF1.58663447
28NEK91.57681979
29SCYL21.55945574
30EPHB21.55513065
31MAP2K41.54349126
32FGFR21.53327459
33DAPK21.52872091
34PTK61.52560216
35MAP2K11.52284463
36FGFR41.47043346
37ADRBK21.44898017
38RIPK11.44212237
39MAPKAPK31.40319487
40NEK11.40174005
41PKN21.38747433
42RIPK41.38711100
43MAP2K21.36519363
44STK38L1.36185020
45MET1.35135179
46RET1.33671701
47GRK11.33513578
48BMPR21.32861083
49MINK11.31998192
50AKT31.29750994
51BCKDK1.27551537
52LIMK11.25634201
53FGR1.18225845
54PTK21.16737333
55PRKG21.12482308
56MATK1.11652081
57BTK1.10281700
58STK381.09080688
59GRK51.08029810
60MAP3K31.07451689
61MAP3K11.07238028
62PIK3CA1.04301606
63PDK21.03782511
64LRRK21.03047400
65PHKG11.02022579
66PHKG21.02022579
67BMPR1B0.99930038
68STK390.97881993
69ZAP700.95354858
70TESK10.93194378
71MAP3K110.91732511
72CAMKK10.90503046
73EPHA40.88838229
74SYK0.88552442
75TBK10.88427967
76SIK10.87660479
77TYK20.87215388
78MAP3K120.86247589
79ERBB20.85413522
80MAP3K140.84235654
81ILK0.82621211
82MAP4K20.81826275
83PRKCE0.80236069
84NTRK20.78711134
85TAF10.78190058
86SIK30.77565972
87NTRK30.77318637
88NLK0.76625432
89MAP3K130.74859184
90CSF1R0.74426136
91TRIB30.73100638
92WNK30.70425841
93EPHA30.69271776
94ADRBK10.68979990
95YES10.68246920
96SGK30.64137114
97PRKCG0.63714525
98CASK0.62151407
99PRKG10.61083756
100MAPK130.60096426
101ABL20.59431825
102NUAK10.58311920
103RPS6KB20.58188819
104MAP3K40.57790131
105JAK20.57458263
106STK100.56798015
107BMX0.56380202
108GRK60.56027293
109IRAK10.55779542
110PAK40.55651198
111PDPK10.55559983
112PRKD10.54859513
113PRKCZ0.54751729
114TAOK30.54278504
115CAMK2G0.54186453
116MAP3K50.53965822
117ERBB30.52016704
118CAMK1G0.51119763
119CAMK2A0.50851695
120DAPK30.50586809
121PLK30.48853045
122JAK10.47896177
123PAK60.46416911
124STK30.45262473
125PAK10.45171626
126TAOK10.45160864
127OXSR10.44975226
128FGFR30.44629530
129SGK4940.44562874
130SGK2230.44562874
131PRKCA0.42659470
132HCK0.42642160
133RPS6KA20.42349886
134EGFR0.41356118
135SGK20.40543459
136STK40.40142495
137MARK30.39189001
138KSR10.38859081
139CDK60.38777967
140ROCK10.38044910
141PDK40.37948592
142PDK30.37948592
143PDK10.37249989
144PRKCB0.37031028
145PRKCI0.36944173
146CAMK10.35400319
147MAP3K80.34975875
148BCR0.34692411
149DYRK1A0.34573105
150WNK40.34220886
151CAMK2D0.33968594
152TRPM70.33965690
153PAK30.32987791
154PINK10.32909703
155TNK20.32896998
156PRKAA20.32896177
157PRKACG0.30480444
158PDGFRA0.29950656

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.90546800
2Nitrogen metabolism_Homo sapiens_hsa009103.73201029
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.59669178
4Platelet activation_Homo sapiens_hsa046113.35006332
5Arginine biosynthesis_Homo sapiens_hsa002203.16176816
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.94381063
7Complement and coagulation cascades_Homo sapiens_hsa046102.48914036
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.45374456
9Tryptophan metabolism_Homo sapiens_hsa003802.04494817
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.04471306
11SNARE interactions in vesicular transport_Homo sapiens_hsa041301.99793750
12Bile secretion_Homo sapiens_hsa049761.98456552
13Fatty acid degradation_Homo sapiens_hsa000711.93122339
14Pentose and glucuronate interconversions_Homo sapiens_hsa000401.92836086
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.90517286
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.85419551
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.84495541
18Serotonergic synapse_Homo sapiens_hsa047261.82561705
19Arachidonic acid metabolism_Homo sapiens_hsa005901.75861025
20Histidine metabolism_Homo sapiens_hsa003401.72162161
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.69382629
22Retinol metabolism_Homo sapiens_hsa008301.68067709
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.65686576
24Phototransduction_Homo sapiens_hsa047441.64971463
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.58753916
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58228435
27Staphylococcus aureus infection_Homo sapiens_hsa051501.58120138
28Chemical carcinogenesis_Homo sapiens_hsa052041.57448731
29PPAR signaling pathway_Homo sapiens_hsa033201.53818292
30Peroxisome_Homo sapiens_hsa041461.50473536
31Gap junction_Homo sapiens_hsa045401.46721050
32Fat digestion and absorption_Homo sapiens_hsa049751.45524096
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.42696879
34Vascular smooth muscle contraction_Homo sapiens_hsa042701.39605243
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37837851
36Long-term depression_Homo sapiens_hsa047301.36859782
37Circadian entrainment_Homo sapiens_hsa047131.33958387
38Butanoate metabolism_Homo sapiens_hsa006501.29385852
39Phenylalanine metabolism_Homo sapiens_hsa003601.29297243
40Caffeine metabolism_Homo sapiens_hsa002321.27242816
41Renin secretion_Homo sapiens_hsa049241.24991451
42beta-Alanine metabolism_Homo sapiens_hsa004101.24466565
43Sulfur metabolism_Homo sapiens_hsa009201.22226455
44ABC transporters_Homo sapiens_hsa020101.22098992
45ECM-receptor interaction_Homo sapiens_hsa045121.20672307
46Fatty acid metabolism_Homo sapiens_hsa012121.18792533
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18788818
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.15912044
49Insulin secretion_Homo sapiens_hsa049111.15682236
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.14826616
51GABAergic synapse_Homo sapiens_hsa047271.14625896
52Steroid hormone biosynthesis_Homo sapiens_hsa001401.12579136
53Starch and sucrose metabolism_Homo sapiens_hsa005001.11637816
54Synaptic vesicle cycle_Homo sapiens_hsa047211.10612625
55Pyruvate metabolism_Homo sapiens_hsa006201.09006902
56Propanoate metabolism_Homo sapiens_hsa006401.08522745
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07357311
58Morphine addiction_Homo sapiens_hsa050321.06942573
59Vitamin digestion and absorption_Homo sapiens_hsa049771.05272107
60Mineral absorption_Homo sapiens_hsa049781.04548710
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01775526
62Glycerolipid metabolism_Homo sapiens_hsa005611.01051749
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98695895
64Tyrosine metabolism_Homo sapiens_hsa003500.97581098
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97020219
66Selenocompound metabolism_Homo sapiens_hsa004500.94711103
67Glutamatergic synapse_Homo sapiens_hsa047240.90399728
68Sphingolipid metabolism_Homo sapiens_hsa006000.89945132
69Biosynthesis of amino acids_Homo sapiens_hsa012300.89688008
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88304769
71Salivary secretion_Homo sapiens_hsa049700.87632339
72Carbon metabolism_Homo sapiens_hsa012000.87532038
73Folate biosynthesis_Homo sapiens_hsa007900.86296821
74Amphetamine addiction_Homo sapiens_hsa050310.85756063
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84830749
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81632802
77Nicotine addiction_Homo sapiens_hsa050330.81209517
78Dopaminergic synapse_Homo sapiens_hsa047280.77424151
79Alcoholism_Homo sapiens_hsa050340.77371035
80Olfactory transduction_Homo sapiens_hsa047400.76437699
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.76209386
82Steroid biosynthesis_Homo sapiens_hsa001000.73875851
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73067145
84Renin-angiotensin system_Homo sapiens_hsa046140.72023864
85Long-term potentiation_Homo sapiens_hsa047200.68668175
86Chemokine signaling pathway_Homo sapiens_hsa040620.67822809
87Type II diabetes mellitus_Homo sapiens_hsa049300.67310728
88Collecting duct acid secretion_Homo sapiens_hsa049660.66624664
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65294180
90Inositol phosphate metabolism_Homo sapiens_hsa005620.63996713
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62990136
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62456227
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62436909
94Cholinergic synapse_Homo sapiens_hsa047250.61851814
95Fructose and mannose metabolism_Homo sapiens_hsa000510.61794375
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.61640058
97Ether lipid metabolism_Homo sapiens_hsa005650.61474607
98Lysosome_Homo sapiens_hsa041420.56379055
99Arginine and proline metabolism_Homo sapiens_hsa003300.55639320
100Pentose phosphate pathway_Homo sapiens_hsa000300.55378839
101Calcium signaling pathway_Homo sapiens_hsa040200.55192013
102Glutathione metabolism_Homo sapiens_hsa004800.54025384
103Fatty acid elongation_Homo sapiens_hsa000620.51609716
104Hematopoietic cell lineage_Homo sapiens_hsa046400.51502171
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50309400
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.49353626
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.49019668
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48772370
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48668529
110Choline metabolism in cancer_Homo sapiens_hsa052310.47997376
111Adherens junction_Homo sapiens_hsa045200.47882863
112Endocytosis_Homo sapiens_hsa041440.47033103
113Rap1 signaling pathway_Homo sapiens_hsa040150.46886982
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46741095
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45722658
116Bladder cancer_Homo sapiens_hsa052190.42822133
117Dorso-ventral axis formation_Homo sapiens_hsa043200.42330909
118Amoebiasis_Homo sapiens_hsa051460.40855599
119Thyroid cancer_Homo sapiens_hsa052160.39503581
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35773272
121Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34735145
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34717626
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34411176
124Linoleic acid metabolism_Homo sapiens_hsa005910.32929845
125Hepatitis C_Homo sapiens_hsa051600.32520937
126Phagosome_Homo sapiens_hsa041450.32290639
127Prion diseases_Homo sapiens_hsa050200.31846292
128Tight junction_Homo sapiens_hsa045300.29154145
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28939789
130Insulin resistance_Homo sapiens_hsa049310.27485922
131Vibrio cholerae infection_Homo sapiens_hsa051100.26644221
132Fatty acid biosynthesis_Homo sapiens_hsa000610.25742501
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.24920808
134Thyroid hormone synthesis_Homo sapiens_hsa049180.23236602
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.23052122
136Adipocytokine signaling pathway_Homo sapiens_hsa049200.22374771
137Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19378847
138Sulfur relay system_Homo sapiens_hsa041220.18727992
139Gastric acid secretion_Homo sapiens_hsa049710.18141188
140African trypanosomiasis_Homo sapiens_hsa051430.17765208
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.17747754
142Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.17738243
143Pancreatic secretion_Homo sapiens_hsa049720.17613265
144Endometrial cancer_Homo sapiens_hsa052130.17308088
145Phosphatidylinositol signaling system_Homo sapiens_hsa040700.17109861

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