SH3BP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Rho GTPase activating protein (RhoGAP) family. The encoded protein regulates Rac signaling and plays a role in cytoskeletal dynamics, cell motility and epithelial junction formation. This protein's association with the exocyst complex, which tethers secretory vesicles to the plasma membrane, has been demonstrated to be important in cell motility. In a distinct complex, this protein has been shown to regulate epithelial junction formation and morphogenesis. By interacting with the Plexin-D1 cell surface receptor, this protein mediates changes in the cytoskeleton in response to semaphorin binding. This protein may promote metastasis in human liver cancer cells and tissues. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.82803691
2positive regulation of gamma-delta T cell activation (GO:0046645)5.76086804
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.42645002
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.30661808
5antigen processing and presentation of endogenous antigen (GO:0019883)5.23787831
6locomotory exploration behavior (GO:0035641)5.18033522
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.16010067
8synaptic vesicle exocytosis (GO:0016079)5.06240042
9positive regulation by symbiont of host defense response (GO:0052509)5.02009925
10modulation by symbiont of host defense response (GO:0052031)5.02009925
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.02009925
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.02009925
13positive regulation by organism of defense response of other organism involved in symbiotic interact5.02009925
14modulation by symbiont of host immune response (GO:0052553)5.02009925
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.99503423
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.89144382
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.66635648
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.64717568
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.63720834
20negative regulation of cell killing (GO:0031342)4.63720834
21glutamate secretion (GO:0014047)4.62340979
22detection of other organism (GO:0098543)4.55209780
23detection of bacterium (GO:0016045)4.53913007
24neutrophil activation involved in immune response (GO:0002283)4.52217619
25response to peptidoglycan (GO:0032494)4.50803286
26regulation of glutamate receptor signaling pathway (GO:1900449)4.46553213
27vocalization behavior (GO:0071625)4.42782695
28leukocyte aggregation (GO:0070486)4.38913251
29regulation of B cell receptor signaling pathway (GO:0050855)4.32480645
30regulation of synaptic vesicle exocytosis (GO:2000300)4.24040684
31negative regulation of erythrocyte differentiation (GO:0045647)4.21851545
32regulation of gamma-delta T cell activation (GO:0046643)4.18966436
33macrophage activation involved in immune response (GO:0002281)4.18555463
34synaptic vesicle docking involved in exocytosis (GO:0016081)4.14916130
35exploration behavior (GO:0035640)4.12004134
36negative regulation of interleukin-12 production (GO:0032695)4.09261099
37regulation of long-term neuronal synaptic plasticity (GO:0048169)3.97773233
38immunoglobulin mediated immune response (GO:0016064)3.94898051
39G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.94008293
40protein localization to synapse (GO:0035418)3.92198309
41ionotropic glutamate receptor signaling pathway (GO:0035235)3.87057049
42neurotransmitter secretion (GO:0007269)3.85972091
43regulation of neuronal synaptic plasticity (GO:0048168)3.83812777
44regulation of synaptic vesicle transport (GO:1902803)3.83762551
45positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.83706051
46sodium ion export (GO:0071436)3.75739183
47regulation of gamma-delta T cell differentiation (GO:0045586)3.74704895
48neuronal action potential propagation (GO:0019227)3.74421621
49cellular extravasation (GO:0045123)3.73739170
50regulation of synapse structural plasticity (GO:0051823)3.72790107
51response to muramyl dipeptide (GO:0032495)3.67990830
52layer formation in cerebral cortex (GO:0021819)3.67913716
53positive thymic T cell selection (GO:0045059)3.64229540
54detection of external biotic stimulus (GO:0098581)3.64163670
55respiratory burst (GO:0045730)3.58038305
56regulation of mast cell degranulation (GO:0043304)3.54551982
57positive regulation of synapse maturation (GO:0090129)3.52442761
58B cell receptor signaling pathway (GO:0050853)3.52123976
59negative regulation of lymphocyte mediated immunity (GO:0002707)3.50025392
60regulation of interferon-beta biosynthetic process (GO:0045357)3.47551828
61glutamate receptor signaling pathway (GO:0007215)3.47468530
62positive regulation of B cell differentiation (GO:0045579)3.46206788
63long-term memory (GO:0007616)3.43652773
64negative regulation of T cell mediated immunity (GO:0002710)3.41027346
65regulation of myeloid leukocyte mediated immunity (GO:0002886)3.39067583
66regulation of leukocyte degranulation (GO:0043300)3.38856691
67regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.36070637
68positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.34889001
69NIK/NF-kappaB signaling (GO:0038061)3.33753756
70negative regulation of leukocyte mediated immunity (GO:0002704)3.33245058
71cellular potassium ion homeostasis (GO:0030007)3.30985313
72thymic T cell selection (GO:0045061)3.30939710
73regulation of B cell differentiation (GO:0045577)3.29505965
74regulation of T cell tolerance induction (GO:0002664)3.27734974
75synaptic vesicle endocytosis (GO:0048488)3.27163028
76synaptic transmission, glutamatergic (GO:0035249)3.26666683
77T cell selection (GO:0045058)3.26586469
78dendritic spine morphogenesis (GO:0060997)3.24612963
79response to interleukin-15 (GO:0070672)3.23873004
80detection of biotic stimulus (GO:0009595)3.23817826
81response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.23120186
82response to host immune response (GO:0052572)3.23120186
83neutrophil activation (GO:0042119)3.21929559
84negative regulation of phagocytosis (GO:0050765)3.21656871
85positive regulation of membrane potential (GO:0045838)3.20502320
86regulation of ARF protein signal transduction (GO:0032012)3.19852783
87myeloid cell activation involved in immune response (GO:0002275)3.19398151
88regulation of mast cell activation involved in immune response (GO:0033006)3.17587606
89activation of protein kinase A activity (GO:0034199)3.15592385
90germinal center formation (GO:0002467)3.15102416
91positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.14880708
92regulation of dendritic cell antigen processing and presentation (GO:0002604)3.14848143
93cellular response to type I interferon (GO:0071357)3.14347208
94type I interferon signaling pathway (GO:0060337)3.14347208
95neuron cell-cell adhesion (GO:0007158)3.13843993
96proline transport (GO:0015824)3.13070897
97response to type I interferon (GO:0034340)3.12953013
98neuron-neuron synaptic transmission (GO:0007270)3.12579454
99T cell migration (GO:0072678)3.10641683
100regulation of excitatory postsynaptic membrane potential (GO:0060079)3.09577740
101antigen processing and presentation via MHC class Ib (GO:0002475)3.09240110
102tolerance induction (GO:0002507)3.08682662
103response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.08262784
104response to host (GO:0075136)3.08262784
105response to host defenses (GO:0052200)3.08262784
106granulocyte activation (GO:0036230)3.07359183
107B cell mediated immunity (GO:0019724)3.05831535
108regulation of tolerance induction (GO:0002643)3.05360321
109gamma-aminobutyric acid signaling pathway (GO:0007214)3.04902384
110interferon-gamma-mediated signaling pathway (GO:0060333)3.04813213
111regulation of synaptic plasticity (GO:0048167)3.04662706
112detection of molecule of bacterial origin (GO:0032490)3.02361997
113negative regulation of microtubule polymerization (GO:0031115)3.00262489
114mannose metabolic process (GO:0006013)3.00182777
115lipopolysaccharide-mediated signaling pathway (GO:0031663)2.98381262
116positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.97946783
117neuromuscular process controlling posture (GO:0050884)2.96303585
118response to histamine (GO:0034776)2.96138463
119neuromuscular process controlling balance (GO:0050885)2.95648157
120positive regulation of mast cell activation (GO:0033005)2.94260242
121defense response to protozoan (GO:0042832)2.93875541
122neurotransmitter transport (GO:0006836)2.93380520
123positive T cell selection (GO:0043368)2.93015599
124regulation of antigen processing and presentation (GO:0002577)2.92553539
125positive regulation of synaptic transmission, GABAergic (GO:0032230)2.92328996
126neurotransmitter-gated ion channel clustering (GO:0072578)2.90415306
127regulation of postsynaptic membrane potential (GO:0060078)2.88080897
128positive regulation of dendritic spine morphogenesis (GO:0061003)2.88072047
129positive regulation of neurotransmitter secretion (GO:0001956)2.87425345
130regulation of ARF GTPase activity (GO:0032312)2.86213632
131positive regulation of neurotransmitter transport (GO:0051590)2.85207890
132positive regulation of antigen processing and presentation (GO:0002579)2.84711344
133cerebellar Purkinje cell differentiation (GO:0021702)2.84390675
134dopamine receptor signaling pathway (GO:0007212)2.83861407
135negative regulation of cytokine production involved in immune response (GO:0002719)2.82960464
136regulation of alpha-beta T cell proliferation (GO:0046640)2.82759606
137gamma-aminobutyric acid transport (GO:0015812)2.80210813
138regulation of natural killer cell mediated immunity (GO:0002715)2.80004735
139regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.80004735
140prepulse inhibition (GO:0060134)2.79297824
141negative regulation of innate immune response (GO:0045824)2.79195448
142cellular response to interleukin-15 (GO:0071350)2.78416366
143regulation of regulated secretory pathway (GO:1903305)2.78294987
144regulation of neurotransmitter levels (GO:0001505)2.78099612
145long-term synaptic potentiation (GO:0060291)2.77846224
146regulation of vesicle fusion (GO:0031338)2.77525666
147macrophage activation (GO:0042116)2.76852725
148regulation of mast cell activation (GO:0033003)2.76794847
149response to protozoan (GO:0001562)2.76497000
150myeloid dendritic cell differentiation (GO:0043011)2.75516660
151G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.74812984
152positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.74459202
153myeloid dendritic cell activation (GO:0001773)2.74067321
154regulation of dendritic spine morphogenesis (GO:0061001)2.72818906
155regulation of neurotransmitter secretion (GO:0046928)2.71891246
156signal complex assembly (GO:0007172)2.71754259
157regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.71206252
158regulation of interleukin-2 biosynthetic process (GO:0045076)2.70231700
159positive regulation of fibroblast migration (GO:0010763)2.68726618
160regulation of T cell mediated cytotoxicity (GO:0001914)2.68420095
161membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.68369586
162negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.67211031
163microglial cell activation (GO:0001774)2.66489446
164leukocyte degranulation (GO:0043299)2.66251264
165positive regulation of dendritic spine development (GO:0060999)2.66251003
166clathrin coat assembly (GO:0048268)2.64224299
167regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.63384022
168negative regulation of interleukin-6 production (GO:0032715)2.63329742
169behavioral fear response (GO:0001662)2.61956287
170behavioral defense response (GO:0002209)2.61956287
171vesicle transport along microtubule (GO:0047496)2.59062735
172adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.57470903
173regulation of synaptic transmission, glutamatergic (GO:0051966)2.56359043
174response to pheromone (GO:0019236)2.55025308
175positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.51536499
176regulation of neurotransmitter transport (GO:0051588)2.51429229
177social behavior (GO:0035176)2.50518464
178intraspecies interaction between organisms (GO:0051703)2.50518464
179regulation of clathrin-mediated endocytosis (GO:2000369)2.49848662
180negative thymic T cell selection (GO:0045060)2.48862492
181establishment of synaptic vesicle localization (GO:0097480)2.47972251
182synaptic vesicle transport (GO:0048489)2.47972251
183auditory behavior (GO:0031223)2.46328466
184response to auditory stimulus (GO:0010996)2.46285077
185learning (GO:0007612)2.45957582
186positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.45829488
187positive regulation of synaptic transmission (GO:0050806)2.45590166
188membrane depolarization (GO:0051899)2.45466194
189negative T cell selection (GO:0043383)2.42263572
190regulation of synaptic transmission (GO:0050804)2.42131001
191fear response (GO:0042596)2.40355630
192regulation of synaptic transmission, dopaminergic (GO:0032225)2.39885481
193positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.39063021
194transmission of nerve impulse (GO:0019226)2.37368718
195regulation of defense response to virus by virus (GO:0050690)2.36167545

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.96083929
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.26783730
3RARB_27405468_Chip-Seq_BRAIN_Mouse3.27782291
4* IKZF1_21737484_ChIP-ChIP_HCT116_Human3.23196682
5MYC_22102868_ChIP-Seq_BL_Human3.22135805
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.15579036
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.06424043
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.92575101
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.79130036
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.64955262
11KDM2B_26808549_Chip-Seq_SUP-B15_Human2.52333624
12REST_21632747_ChIP-Seq_MESCs_Mouse2.47183789
13VDR_21846776_ChIP-Seq_THP-1_Human2.42401089
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.40539177
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.35148348
16KDM2B_26808549_Chip-Seq_DND41_Human2.34471338
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.31835993
18DROSHA_22980978_ChIP-Seq_HELA_Human2.24546603
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.24469818
20* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.24157979
21* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.23337228
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.21773134
23* SPI1_23547873_ChIP-Seq_NB4_Human2.20875419
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.19588791
25E2F7_22180533_ChIP-Seq_HELA_Human2.17549966
26JARID2_20064375_ChIP-Seq_MESCs_Mouse2.17009287
27DNAJC2_21179169_ChIP-ChIP_NT2_Human2.16878155
28* TCF7_22412390_ChIP-Seq_EML_Mouse2.13935786
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.12589269
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.11691343
31BRD4_27068464_Chip-Seq_AML-cells_Mouse2.05807190
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.02831850
33* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.00994426
34SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.92309476
35* LXR_22292898_ChIP-Seq_THP-1_Human1.89399253
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.86924056
37KDM2B_26808549_Chip-Seq_K562_Human1.85986132
38GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.85526323
39KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.85012111
40EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.83913543
41* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.83114814
42* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.82278718
43MYB_26560356_Chip-Seq_TH1_Human1.78668138
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73907509
45SCL_19346495_ChIP-Seq_HPC-7_Human1.73762119
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.72988015
47TP63_17297297_ChIP-ChIP_HaCaT_Human1.72949983
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.72275317
49KDM2B_26808549_Chip-Seq_JURKAT_Human1.71839155
50SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.71727908
51SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.70503470
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.68878432
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.68527526
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.68527526
55* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.63212640
56MTF2_20144788_ChIP-Seq_MESCs_Mouse1.61495945
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.60461683
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55344291
59E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.54015365
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52632422
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.51667388
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.51613973
63* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.51034618
64RNF2_27304074_Chip-Seq_ESCs_Mouse1.50777087
65* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.50524573
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.49612849
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.48608341
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48545908
69SPI1_23127762_ChIP-Seq_K562_Human1.48387058
70SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.47018933
71MAF_26560356_Chip-Seq_TH1_Human1.46785210
72UTX_26944678_Chip-Seq_JUKART_Human1.44935836
73RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.44829132
74EZH2_27294783_Chip-Seq_ESCs_Mouse1.44236687
75RACK7_27058665_Chip-Seq_MCF-7_Human1.43138111
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43003098
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.42660852
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40108717
79* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39546309
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35943228
81RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.35660607
82EZH2_27304074_Chip-Seq_ESCs_Mouse1.35555669
83* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35141661
84VDR_24763502_ChIP-Seq_THP-1_Human1.33797180
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33791498
86* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33488594
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32594017
88TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.32472272
89SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.32051151
90GATA2_22383799_ChIP-Seq_G1ME_Mouse1.31143772
91CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30765887
92SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.30553773
93* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.29301115
94CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27784807
95CIITA_25753668_ChIP-Seq_RAJI_Human1.26066296
96NCOR1_26117541_ChIP-Seq_K562_Human1.25354431
97DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23700481
98LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23412431
99* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22342396
100Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22231044
101* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21096248
102* BCOR_27268052_Chip-Seq_Bcells_Human1.20948451
103ELK3_25401928_ChIP-Seq_HUVEC_Human1.20926362
104TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19968386
105GATA3_27048872_Chip-Seq_THYMUS_Human1.19113722
106* SMC4_20622854_ChIP-Seq_HELA_Human1.16983589
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14365785
108TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14122240
109* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13603657
110* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13246877
111VDR_24787735_ChIP-Seq_THP-1_Human1.12075093
112GATA1_19941826_ChIP-Seq_K562_Human1.11941597
113MAF_26560356_Chip-Seq_TH2_Human1.11430902
114SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10587200
115CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09977510
116KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09660419
117SA1_27219007_Chip-Seq_ERYTHROID_Human1.09568444
118* P68_20966046_ChIP-Seq_HELA_Human1.09473835
119PU_27001747_Chip-Seq_BMDM_Mouse1.09036150
120ELF1_20517297_ChIP-Seq_JURKAT_Human1.08062211
121CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07990414
122CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07626410
123GATA1_19941827_ChIP-Seq_MEL_Mouse1.06403252
124RUNX_20019798_ChIP-Seq_JUKART_Human1.05922308
125RING1B_27294783_Chip-Seq_ESCs_Mouse1.05288106
126CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05070759
127PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04990017
128* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04879387
129GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04763268
130FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.03710671
131TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03602186
132ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03518992
133* RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98989566
134TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97785792
135* RUNX1_22412390_ChIP-Seq_EML_Mouse0.97264147
136TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96980395
137KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95662039
138* BCL6_27268052_Chip-Seq_Bcells_Human0.95440342
139CTCF_21964334_ChIP-Seq_BJAB-B_Human0.94703411
140CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93842017
141AR_21572438_ChIP-Seq_LNCaP_Human0.93778669
142MYB_26560356_Chip-Seq_TH2_Human0.93759167
143LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93399076
144NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91259156
145SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90374377
146CREB1_26743006_Chip-Seq_LNCaP_Human0.90135290
147TET1_21451524_ChIP-Seq_MESCs_Mouse0.89999634
148* SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.88656483
149OCT4_19829295_ChIP-Seq_ESCs_Human0.88466040
150CTCF_27219007_Chip-Seq_Bcells_Human0.88056419
151MYB_21317192_ChIP-Seq_ERMYB_Mouse0.87610560
152TET1_21490601_ChIP-Seq_MESCs_Mouse0.87071146
153SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.87047282
154SA1_27219007_Chip-Seq_Bcells_Human0.85825383

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.38872907
2MP0003436_decreased_susceptibility_to4.06324442
3MP0003880_abnormal_central_pattern4.01401632
4MP0003635_abnormal_synaptic_transmissio3.88786250
5MP0003724_increased_susceptibility_to3.13364696
6MP0009745_abnormal_behavioral_response3.00859508
7MP0002063_abnormal_learning/memory/cond3.00644204
8MP0002419_abnormal_innate_immunity2.88052501
9MP0002064_seizures2.86609252
10MP0003300_gastrointestinal_ulcer2.82410978
11MP0005025_abnormal_response_to2.75136369
12MP0009046_muscle_twitch2.71749661
13MP0005423_abnormal_somatic_nervous2.60552494
14MP0001968_abnormal_touch/_nociception2.57198929
15MP0009785_altered_susceptibility_to2.54415368
16MP0002572_abnormal_emotion/affect_behav2.47520534
17MP0006082_CNS_inflammation2.45500130
18MP0005058_abnormal_lysosome_morphology2.26312664
19MP0002822_catalepsy2.26126570
20MP0004270_analgesia2.22413071
21MP0002148_abnormal_hypersensitivity_rea2.21016491
22MP0004947_skin_inflammation2.10115468
23MP0010155_abnormal_intestine_physiology2.09278219
24MP0009333_abnormal_splenocyte_physiolog2.05496980
25MP0008569_lethality_at_weaning1.99154686
26MP0002272_abnormal_nervous_system1.98162195
27MP0008260_abnormal_autophagy1.95454943
28MP0003191_abnormal_cellular_cholesterol1.93694841
29MP0002736_abnormal_nociception_after1.92191699
30MP0001533_abnormal_skeleton_physiology1.91746220
31MP0005451_abnormal_body_composition1.90603974
32MP0001501_abnormal_sleep_pattern1.89202902
33MP0003787_abnormal_imprinting1.82331343
34MP0003303_peritoneal_inflammation1.80148224
35MP0004510_myositis1.79033173
36MP0003122_maternal_imprinting1.77095453
37MP0004811_abnormal_neuron_physiology1.76614010
38MP0001486_abnormal_startle_reflex1.76595780
39MP0000858_altered_metastatic_potential1.72813804
40MP0001845_abnormal_inflammatory_respons1.71953992
41MP0001970_abnormal_pain_threshold1.69261382
42MP0002733_abnormal_thermal_nociception1.69061473
43MP0002734_abnormal_mechanical_nocicepti1.62683046
44MP0004858_abnormal_nervous_system1.60211326
45MP0001440_abnormal_grooming_behavior1.53544694
46MP0001873_stomach_inflammation1.51331930
47MP0003828_pulmonary_edema1.50332139
48MP0002184_abnormal_innervation1.49773183
49MP0008961_abnormal_basal_metabolism1.49159431
50MP0003123_paternal_imprinting1.48248922
51MP0002067_abnormal_sensory_capabilities1.46853881
52MP0009840_abnormal_foam_cell1.46602496
53MP0003172_abnormal_lysosome_physiology1.45931281
54MP0002557_abnormal_social/conspecific_i1.45294985
55MP0002909_abnormal_adrenal_gland1.44352362
56MP0003329_amyloid_beta_deposits1.44119090
57MP0000465_gastrointestinal_hemorrhage1.43694643
58MP0002998_abnormal_bone_remodeling1.41603054
59MP0008469_abnormal_protein_level1.39567642
60MP0002735_abnormal_chemical_nociception1.39090433
61MP0004381_abnormal_hair_follicle1.37295554
62MP0002132_abnormal_respiratory_system1.34451227
63MP0000490_abnormal_crypts_of1.32977816
64MP0004924_abnormal_behavior1.29094345
65MP0005386_behavior/neurological_phenoty1.29094345
66MP0001851_eye_inflammation1.24568293
67MP0003763_abnormal_thymus_physiology1.23345956
68MP0000955_abnormal_spinal_cord1.21961173
69MP0008872_abnormal_physiological_respon1.21301432
70MP0000569_abnormal_digit_pigmentation1.21149821
71MP0003705_abnormal_hypodermis_morpholog1.20766982
72MP0001529_abnormal_vocalization1.19853179
73MP0003879_abnormal_hair_cell1.18843033
74MP0002396_abnormal_hematopoietic_system1.17496626
75MP0003453_abnormal_keratinocyte_physiol1.17448708
76MP0001853_heart_inflammation1.17367496
77MP0004142_abnormal_muscle_tone1.13578564
78MP0005499_abnormal_olfactory_system1.13181770
79MP0005394_taste/olfaction_phenotype1.13181770
80MP0003075_altered_response_to1.12360115
81MP0002066_abnormal_motor_capabilities/c1.10690042
82MP0003121_genomic_imprinting1.10237059
83MP0002398_abnormal_bone_marrow1.10058058
84MP0000685_abnormal_immune_system1.09622978
85MP0002166_altered_tumor_susceptibility1.08123453
86MP0005671_abnormal_response_to1.07749406
87MP0005166_decreased_susceptibility_to1.06727405
88MP0002882_abnormal_neuron_morphology1.06207316
89MP0005310_abnormal_salivary_gland1.04172526
90MP0008874_decreased_physiological_sensi1.03442519
91MP0001905_abnormal_dopamine_level1.02973949
92MP0001849_ear_inflammation1.00992601
93MP0003448_altered_tumor_morphology1.00957285
94MP0009764_decreased_sensitivity_to1.00836960
95MP0000778_abnormal_nervous_system1.00434687
96MP0000703_abnormal_thymus_morphology0.97121946
97MP0000343_altered_response_to0.96615381
98MP0002152_abnormal_brain_morphology0.95567685
99MP0003633_abnormal_nervous_system0.94799331
100MP0001348_abnormal_lacrimal_gland0.94155783
101MP0005645_abnormal_hypothalamus_physiol0.93701837
102MP0001502_abnormal_circadian_rhythm0.93422338
103MP0005174_abnormal_tail_pigmentation0.93306041
104MP0002420_abnormal_adaptive_immunity0.90601305
105MP0001663_abnormal_digestive_system0.90213755
106MP0006276_abnormal_autonomic_nervous0.90194088
107MP0001819_abnormal_immune_cell0.89855954
108MP0001545_abnormal_hematopoietic_system0.89715942
109MP0005397_hematopoietic_system_phenotyp0.89715942
110MP0001984_abnormal_olfaction0.89340314
111MP0003091_abnormal_cell_migration0.88855310
112MP0004883_abnormal_blood_vessel0.88020374
113MP0004808_abnormal_hematopoietic_stem0.87278130
114MP0003866_abnormal_defecation0.85608762
115MP0002933_joint_inflammation0.84740615
116MP0008004_abnormal_stomach_pH0.84012527
117MP0003806_abnormal_nucleotide_metabolis0.83686174
118MP0001800_abnormal_humoral_immune0.83601134
119MP0004264_abnormal_extraembryonic_tissu0.83548671
120MP0001835_abnormal_antigen_presentation0.83038033
121MP0005390_skeleton_phenotype0.82411594
122MP0002722_abnormal_immune_system0.82009339
123MP0003690_abnormal_glial_cell0.81797211
124MP0008770_decreased_survivor_rate0.81342196
125MP0000716_abnormal_immune_system0.80886422
126MP0003566_abnormal_cell_adhesion0.78365201
127MP0002723_abnormal_immune_serum0.78058502
128MP0010234_abnormal_vibrissa_follicle0.78040447
129MP0002796_impaired_skin_barrier0.77842480
130MP0005000_abnormal_immune_tolerance0.77255951
131MP0009763_increased_sensitivity_to0.76061063
132MP0008877_abnormal_DNA_methylation0.74197874
133MP0002277_abnormal_respiratory_mucosa0.73998605
134MP0003183_abnormal_peptide_metabolism0.73716831
135MP0003795_abnormal_bone_structure0.72847983
136MP0004185_abnormal_adipocyte_glucose0.72646451
137MP0000689_abnormal_spleen_morphology0.72461014
138MP0003631_nervous_system_phenotype0.72290608
139MP0000604_amyloidosis0.71676185
140MP0002138_abnormal_hepatobiliary_system0.71343192
141MP0002452_abnormal_antigen_presenting0.71070515
142MP0005464_abnormal_platelet_physiology0.70270893
143MP0005646_abnormal_pituitary_gland0.69260019
144MP0002254_reproductive_system_inflammat0.68586359
145MP0002006_tumorigenesis0.68115666
146MP0004885_abnormal_endolymph0.67358083
147MP0005164_abnormal_response_to0.67137642
148MP0002429_abnormal_blood_cell0.66374353
149MP0002069_abnormal_eating/drinking_beha0.65239161
150MP0005387_immune_system_phenotype0.62538571
151MP0001790_abnormal_immune_system0.62538571
152MP0002653_abnormal_ependyma_morphology0.61690360
153MP0002019_abnormal_tumor_incidence0.61171947
154MP0000249_abnormal_blood_vessel0.61058273
155MP0005076_abnormal_cell_differentiation0.60668417
156MP0005075_abnormal_melanosome_morpholog0.59980346
157MP0009278_abnormal_bone_marrow0.59365677
158MP0005381_digestive/alimentary_phenotyp0.58134785
159MP0000015_abnormal_ear_pigmentation0.57853358
160MP0009765_abnormal_xenobiotic_induced0.57769356
161MP0002877_abnormal_melanocyte_morpholog0.57634335
162MP0005023_abnormal_wound_healing0.57489981
163MP0002083_premature_death0.56850604
164MP0002405_respiratory_system_inflammati0.55982006

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.15357879
2Focal motor seizures (HP:0011153)5.74118150
3Recurrent bacterial skin infections (HP:0005406)5.36185093
4Recurrent abscess formation (HP:0002722)5.32968164
5Visual hallucinations (HP:0002367)5.25661723
6Abnormality of macrophages (HP:0004311)5.09534265
7Myokymia (HP:0002411)5.07348772
8Focal seizures (HP:0007359)4.51582439
9Myositis (HP:0100614)4.28746631
10Recurrent gram-negative bacterial infections (HP:0005420)3.95460112
11Orchitis (HP:0100796)3.82768552
12Obstructive lung disease (HP:0006536)3.78303751
13Chronic obstructive pulmonary disease (HP:0006510)3.78303751
14Meningitis (HP:0001287)3.71072083
15Epileptic encephalopathy (HP:0200134)3.64883971
16Atonic seizures (HP:0010819)3.57612916
17Recurrent skin infections (HP:0001581)3.56928163
18Annular pancreas (HP:0001734)3.51272312
19Papilledema (HP:0001085)3.47345044
20Retrobulbar optic neuritis (HP:0100654)3.47082378
21Optic neuritis (HP:0100653)3.47082378
22Progressive cerebellar ataxia (HP:0002073)3.46464459
23Febrile seizures (HP:0002373)3.40912690
24Stomatitis (HP:0010280)3.39156021
25Spontaneous hematomas (HP:0007420)3.37130061
26Cellulitis (HP:0100658)3.34124285
27Gastrointestinal infarctions (HP:0005244)3.24103761
28Chronic mucocutaneous candidiasis (HP:0002728)3.23415779
29Recurrent cutaneous fungal infections (HP:0011370)3.23415779
30Recurrent viral infections (HP:0004429)3.18349356
31Pustule (HP:0200039)3.18055126
32Gingivitis (HP:0000230)3.18052704
33Gastrointestinal inflammation (HP:0004386)3.14988536
34Absence seizures (HP:0002121)3.13127386
35Inflammation of the large intestine (HP:0002037)3.10607519
36Vasculitis (HP:0002633)3.10087082
37Supranuclear gaze palsy (HP:0000605)3.08213619
38Urticaria (HP:0001025)3.06552348
39Colitis (HP:0002583)3.03654917
40Depression (HP:0000716)3.02370127
41Mutism (HP:0002300)3.00615216
42Encephalitis (HP:0002383)3.00154028
43Dialeptic seizures (HP:0011146)2.92944831
44Abnormality of the lower motor neuron (HP:0002366)2.90545186
45Amyotrophic lateral sclerosis (HP:0007354)2.86597032
46Pointed chin (HP:0000307)2.83798515
47Diplopia (HP:0000651)2.82915822
48Abnormality of binocular vision (HP:0011514)2.82915822
49Impaired smooth pursuit (HP:0007772)2.80676110
50Abnormality of liposaccharide metabolism (HP:0010968)2.78789994
51Abnormality of glycosphingolipid metabolism (HP:0004343)2.78789994
52Abnormality of glycolipid metabolism (HP:0010969)2.78789994
53Prolonged bleeding time (HP:0003010)2.78304214
54Generalized tonic-clonic seizures (HP:0002069)2.69474141
55Hyperacusis (HP:0010780)2.67919014
56Agammaglobulinemia (HP:0004432)2.64219005
57Elevated erythrocyte sedimentation rate (HP:0003565)2.62846315
58Hemiplegia (HP:0002301)2.62519209
59Poor eye contact (HP:0000817)2.62053537
60Petechiae (HP:0000967)2.60202683
61Chest pain (HP:0100749)2.59294108
62Gastrointestinal stroma tumor (HP:0100723)2.58219299
63T lymphocytopenia (HP:0005403)2.57725410
64Insomnia (HP:0100785)2.57664502
65Keratoconjunctivitis sicca (HP:0001097)2.56921935
66Truncal ataxia (HP:0002078)2.55119662
67Lymphopenia (HP:0001888)2.50802642
68Increased neuronal autofluorescent lipopigment (HP:0002074)2.50392803
69Pulmonary infiltrates (HP:0002113)2.49619706
70Abnormality of ocular smooth pursuit (HP:0000617)2.47092743
71Osteomyelitis (HP:0002754)2.46710954
72Epistaxis (HP:0000421)2.45947895
73Hemoptysis (HP:0002105)2.45940445
74Ankle clonus (HP:0011448)2.45727213
75Impaired social interactions (HP:0000735)2.44812576
76Abnormal social behavior (HP:0012433)2.44812576
77Apathy (HP:0000741)2.43954288
78Amblyopia (HP:0000646)2.41132364
79Stereotypic behavior (HP:0000733)2.40560186
80Loss of speech (HP:0002371)2.39178047
81Abnormality of cells of the lymphoid lineage (HP:0012140)2.38468612
82Diminished motivation (HP:0000745)2.37697077
83Dysostosis multiplex (HP:0000943)2.37176209
84Abnormality of T cell number (HP:0011839)2.35933302
85Abnormal eating behavior (HP:0100738)2.35653479
86Systemic lupus erythematosus (HP:0002725)2.35299264
87Abnormality of T cells (HP:0002843)2.34804220
88Purpura (HP:0000979)2.34729222
89Premature loss of primary teeth (HP:0006323)2.33643571
90Postural instability (HP:0002172)2.30250971
91Malnutrition (HP:0004395)2.29173731
92Broad-based gait (HP:0002136)2.27855338
93Keratoconjunctivitis (HP:0001096)2.27827017
94Failure to thrive in infancy (HP:0001531)2.26778389
95Large eyes (HP:0001090)2.26328480
96Hemiparesis (HP:0001269)2.25989982
97Action tremor (HP:0002345)2.25883769
98Granulocytopenia (HP:0001913)2.24703201
99Genetic anticipation (HP:0003743)2.24487845
100Impaired vibration sensation in the lower limbs (HP:0002166)2.23970045
101Increased IgM level (HP:0003496)2.23759364
102Dysmetric saccades (HP:0000641)2.20523504
103Gaze-evoked nystagmus (HP:0000640)2.19736782
104Gingival bleeding (HP:0000225)2.18405520
105Dysdiadochokinesis (HP:0002075)2.18095186
106Amyloidosis (HP:0011034)2.18066704
107Leukocytosis (HP:0001974)2.17421183
108Increased serum ferritin (HP:0003281)2.17045295
109Skin ulcer (HP:0200042)2.16296113
110Sepsis (HP:0100806)2.15547467
111Hypochromic anemia (HP:0001931)2.14676025
112Bradykinesia (HP:0002067)2.14151565
113IgM deficiency (HP:0002850)2.13592500
114Vacuolated lymphocytes (HP:0001922)2.13512228
115Urinary bladder sphincter dysfunction (HP:0002839)2.13492980
116Arterial thrombosis (HP:0004420)2.13047003
117Slow saccadic eye movements (HP:0000514)2.11548148
118Dysmetria (HP:0001310)2.10023109
119Verrucae (HP:0200043)2.09482349
120Papilloma (HP:0012740)2.09482349
121Urinary urgency (HP:0000012)2.09323861
122Pulmonary embolism (HP:0002204)2.07602955
123Progressive inability to walk (HP:0002505)2.07293430
124Hypergammaglobulinemia (HP:0010702)2.07203485
125Polygenic inheritance (HP:0010982)2.06495741
126Restrictive lung disease (HP:0002091)2.05255195
127Abnormality of T cell physiology (HP:0011840)2.04885304
128Viral hepatitis (HP:0006562)2.03057400
129Deep palmar crease (HP:0006191)2.02374174
130Hepatosplenomegaly (HP:0001433)2.02258174
131Chronic otitis media (HP:0000389)2.00853958
132Spinal canal stenosis (HP:0003416)1.99796874
133Generalized hypotonia (HP:0001290)1.99195420
134Iris hypopigmentation (HP:0007730)1.98082528
135Obstructive sleep apnea (HP:0002870)1.96678667
136Ankyloglossia (HP:0010296)1.96469394
137Abnormality of oral frenula (HP:0000190)1.96136478
138Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.95879213
139Episodic fever (HP:0001954)1.95732627
140Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.95677961
141Anxiety (HP:0000739)1.95072356
142Anorexia (HP:0002039)1.93805246
143Inappropriate behavior (HP:0000719)1.93444127
144Hypertensive crisis (HP:0100735)1.90168832
145Emphysema (HP:0002097)1.90032451
146Hypercortisolism (HP:0001578)1.87531709
147Glomerulopathy (HP:0100820)1.87388877
148Panhypogammaglobulinemia (HP:0003139)1.86236101
149Segmental peripheral demyelination/remyelination (HP:0003481)1.85942069
150Thoracic kyphosis (HP:0002942)1.85340649
151Neuronal loss in central nervous system (HP:0002529)1.85229191
152Nasal polyposis (HP:0100582)1.84220551
153Autoimmune thrombocytopenia (HP:0001973)1.81903573
154Acute lymphatic leukemia (HP:0006721)1.80981086
155Rapidly progressive (HP:0003678)1.79718746
156Skin rash (HP:0000988)1.78858319
157Abnormal delayed hypersensitivity skin test (HP:0002963)1.78476509
158Upper motor neuron abnormality (HP:0002127)1.77649493
159Ocular albinism (HP:0001107)1.77262879
160Abnormality of the fingertips (HP:0001211)1.77088445
161Recurrent lower respiratory tract infections (HP:0002783)1.75929325
162Abnormality of the peritoneum (HP:0002585)1.75238838
163Abnormality of iron homeostasis (HP:0011031)1.74786115
164Basal cell carcinoma (HP:0002671)1.73177763
165Status epilepticus (HP:0002133)1.71242814
166Horizontal nystagmus (HP:0000666)1.67692642
167Fatigue (HP:0012378)1.65260600
168Atrophy/Degeneration involving motor neurons (HP:0007373)1.63410462
169Focal dystonia (HP:0004373)1.63396998
170Neoplasm of the heart (HP:0100544)1.62920646
171Spastic gait (HP:0002064)1.61297752
172Limb dystonia (HP:0002451)1.60924497
173Ependymoma (HP:0002888)1.60356901
174Psychosis (HP:0000709)1.60311412
175Delusions (HP:0000746)1.59666846
176Polyphagia (HP:0002591)1.59546661
177Limb ataxia (HP:0002070)1.59302858
178Increased IgE level (HP:0003212)1.58887900
179Inability to walk (HP:0002540)1.58314105
180Elfin facies (HP:0004428)1.57928100
181Macroglossia (HP:0000158)1.57042001
182Recurrent fungal infections (HP:0002841)1.56032661
183Centrally nucleated skeletal muscle fibers (HP:0003687)1.55847073
184Dementia (HP:0000726)1.55761070
185Overriding aorta (HP:0002623)1.55396059
186Lower limb asymmetry (HP:0100559)1.54764751
187Mediastinal lymphadenopathy (HP:0100721)1.54536295
188Torticollis (HP:0000473)1.53829537
189Increased cerebral lipofuscin (HP:0011813)1.53577243
190Drooling (HP:0002307)1.53233904
191Excessive salivation (HP:0003781)1.53233904

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.14333679
2NTRK33.68475045
3EPHA43.23548999
4ERN13.18373201
5SIK22.58938733
6RIPK42.56923329
7MAP3K132.47405255
8MAP3K122.44553444
9MINK12.38365827
10IRAK42.36126782
11FES2.32980300
12MAP2K32.28779185
13KSR22.21671691
14CSK2.14151552
15DAPK12.10204401
16SMG12.07495759
17MAP3K42.00194408
18NTRK21.99982829
19MAP3K141.97987443
20CDK191.95051544
21CAMKK11.87452093
22EEF2K1.83335032
23DAPK21.80457150
24PAK61.77069115
25GRK61.77027314
26BTK1.69516792
27MAP4K11.61991691
28KSR11.60621667
29TAOK11.59021638
30MARK11.57980065
31MAP3K31.50648982
32TBK11.46905255
33PRKD31.45597563
34TYRO31.44863557
35EPHB11.44793690
36MAP2K71.43737554
37GRK51.43172810
38MAP2K41.42560201
39SIK11.42005369
40IKBKE1.37689301
41ALK1.37675365
42SCYL21.37294056
43IRAK31.35477726
44TXK1.34784386
45FGFR41.30564135
46TNK21.28341304
47MARK31.28216525
48CDK51.26717858
49RAF11.25478894
50CDK121.22103580
51ARAF1.21049706
52NTRK11.20742769
53JAK11.20218949
54STK101.16834926
55PKN21.16565408
56UHMK11.15919939
57LYN1.09952341
58PTK61.07920431
59ITK1.07510849
60CDC42BPA1.06698723
61PRPF4B1.05389256
62TNIK1.03395410
63CAMKK21.01286053
64MAP3K110.97843482
65SYK0.95889190
66TRIB30.94134463
67IKBKB0.93560344
68CDK180.91957113
69CDK150.90878139
70STK110.90379576
71CAMK10.88389084
72CDK11A0.87259457
73PRKCH0.85947243
74RET0.84479062
75STK380.84030505
76BRSK10.83724373
77CDK140.83123374
78NME20.81460816
79SIK30.80628404
80MAP3K100.79016937
81NEK10.78378223
82ZAP700.77615629
83PNCK0.76402391
84MAPK130.75556188
85MARK20.74693331
86MAP3K60.74683560
87CDK40.72862618
88FGFR30.72210597
89IRAK20.71451409
90PRKCG0.68666964
91MAPK120.67987228
92LRRK20.67929118
93TGFBR20.67459318
94HCK0.67025140
95CCNB10.65978188
96PDK10.65965442
97RIPK10.65828521
98YES10.65421806
99MAP3K80.62272097
100PLK20.61048682
101MOS0.59334498
102MAPK70.58675214
103RPS6KL10.58392485
104RPS6KC10.58392485
105MAP3K70.58064517
106TEC0.57673031
107BLK0.57117632
108MAP3K10.56495649
109KIT0.56247280
110CAMK40.54804267
111FGR0.53943574
112TTN0.52674891
113PIM10.52320880
114CSF1R0.51504699
115PRKCQ0.49632921
116MAPK110.49269188
117PRKG20.48530544
118NEK20.48402443
119HIPK20.48350742
120MATK0.47739113
121CDK60.47023418
122IRAK10.46768878
123DAPK30.45915813
124MAP2K20.45609536
125PRKD20.45247846
126FYN0.44146178
127RPS6KA60.43719576
128BMPR20.43475395
129LATS20.42973369
130RPS6KA20.42060410
131CLK10.41629199
132MAPKAPK20.40025800
133BMX0.39009017
134MAP2K60.38514045
135MAPK100.38413717
136TAOK30.37493503
137PAK40.37137167
138PTK2B0.36585866
139LCK0.36573663
140MAP3K20.35367462
141TESK20.34977882
142SGK30.34001750
143CDC70.33754678
144JAK30.31891394
145RPS6KA30.31125226
146SGK10.31097925
147ICK0.30960222
148TYK20.30942520
149PRKCZ0.30584473
150JAK20.30411903
151TAOK20.30293422
152PDPK10.29827578
153CAMK2A0.29778032

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.67638211
2Synaptic vesicle cycle_Homo sapiens_hsa047212.62301488
3Staphylococcus aureus infection_Homo sapiens_hsa051502.43734164
4Allograft rejection_Homo sapiens_hsa053302.40831143
5Other glycan degradation_Homo sapiens_hsa005112.35250916
6Graft-versus-host disease_Homo sapiens_hsa053322.33749327
7Olfactory transduction_Homo sapiens_hsa047402.28771713
8Long-term potentiation_Homo sapiens_hsa047202.25642158
9Autoimmune thyroid disease_Homo sapiens_hsa053202.24027539
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.14359170
11Circadian entrainment_Homo sapiens_hsa047132.00880260
12Morphine addiction_Homo sapiens_hsa050321.97990756
13GABAergic synapse_Homo sapiens_hsa047271.95795132
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.94528260
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.94080197
16Glutamatergic synapse_Homo sapiens_hsa047241.92590450
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.89673840
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.85532079
19Amphetamine addiction_Homo sapiens_hsa050311.81321730
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.78387399
21Antigen processing and presentation_Homo sapiens_hsa046121.77213250
22Dopaminergic synapse_Homo sapiens_hsa047281.74048140
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.67846784
24Viral myocarditis_Homo sapiens_hsa054161.64213274
25Toxoplasmosis_Homo sapiens_hsa051451.62872370
26Salivary secretion_Homo sapiens_hsa049701.61237522
27Measles_Homo sapiens_hsa051621.57474869
28Asthma_Homo sapiens_hsa053101.54576944
29Hematopoietic cell lineage_Homo sapiens_hsa046401.54519728
30Influenza A_Homo sapiens_hsa051641.52221631
31Cholinergic synapse_Homo sapiens_hsa047251.49382705
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.49066611
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.46187287
34Oxytocin signaling pathway_Homo sapiens_hsa049211.45972026
35Herpes simplex infection_Homo sapiens_hsa051681.44923710
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43212116
37Malaria_Homo sapiens_hsa051441.43111049
38Gastric acid secretion_Homo sapiens_hsa049711.40347283
39Long-term depression_Homo sapiens_hsa047301.40058124
40GnRH signaling pathway_Homo sapiens_hsa049121.34407981
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32900771
42TNF signaling pathway_Homo sapiens_hsa046681.32756119
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31331860
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28881141
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.27559977
46Renin secretion_Homo sapiens_hsa049241.27206688
47Cocaine addiction_Homo sapiens_hsa050301.25591694
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24936830
49Phagosome_Homo sapiens_hsa041451.19796599
50Glioma_Homo sapiens_hsa052141.19738662
51Leukocyte transendothelial migration_Homo sapiens_hsa046701.19221981
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18256971
53Gap junction_Homo sapiens_hsa045401.17981892
54Neurotrophin signaling pathway_Homo sapiens_hsa047221.17159505
55VEGF signaling pathway_Homo sapiens_hsa043701.16777946
56Serotonergic synapse_Homo sapiens_hsa047261.16669282
57Insulin secretion_Homo sapiens_hsa049111.16465291
58Taste transduction_Homo sapiens_hsa047421.16310132
59Calcium signaling pathway_Homo sapiens_hsa040201.15993040
60Lysosome_Homo sapiens_hsa041421.14421827
61Estrogen signaling pathway_Homo sapiens_hsa049151.14072111
62Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12267924
63Legionellosis_Homo sapiens_hsa051341.11727880
64Pertussis_Homo sapiens_hsa051331.11115086
65Hepatitis C_Homo sapiens_hsa051601.11090331
66Jak-STAT signaling pathway_Homo sapiens_hsa046301.09847117
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07844792
68Apoptosis_Homo sapiens_hsa042101.07125447
69Rheumatoid arthritis_Homo sapiens_hsa053231.05778438
70Oocyte meiosis_Homo sapiens_hsa041141.05710645
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04214537
72B cell receptor signaling pathway_Homo sapiens_hsa046621.03397768
73T cell receptor signaling pathway_Homo sapiens_hsa046601.03221249
74Non-small cell lung cancer_Homo sapiens_hsa052230.95680514
75cAMP signaling pathway_Homo sapiens_hsa040240.93878816
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.93815451
77Chemokine signaling pathway_Homo sapiens_hsa040620.91862188
78ErbB signaling pathway_Homo sapiens_hsa040120.91740989
79mTOR signaling pathway_Homo sapiens_hsa041500.89665703
80Notch signaling pathway_Homo sapiens_hsa043300.88961659
81Colorectal cancer_Homo sapiens_hsa052100.88508334
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87657606
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.87356677
84MAPK signaling pathway_Homo sapiens_hsa040100.87237894
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.86470668
86Collecting duct acid secretion_Homo sapiens_hsa049660.86364879
87Osteoclast differentiation_Homo sapiens_hsa043800.85715133
88African trypanosomiasis_Homo sapiens_hsa051430.85650987
89Epstein-Barr virus infection_Homo sapiens_hsa051690.84387252
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84267332
91Type II diabetes mellitus_Homo sapiens_hsa049300.83461688
92Primary immunodeficiency_Homo sapiens_hsa053400.82482984
93Viral carcinogenesis_Homo sapiens_hsa052030.77387602
94Melanogenesis_Homo sapiens_hsa049160.77166474
95HTLV-I infection_Homo sapiens_hsa051660.76149261
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75715148
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74299187
98Acute myeloid leukemia_Homo sapiens_hsa052210.73672017
99Endocytosis_Homo sapiens_hsa041440.73649438
100Type I diabetes mellitus_Homo sapiens_hsa049400.73011809
101Choline metabolism in cancer_Homo sapiens_hsa052310.72320762
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71925222
103Shigellosis_Homo sapiens_hsa051310.71598703
104Platelet activation_Homo sapiens_hsa046110.71427843
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70473636
106Chronic myeloid leukemia_Homo sapiens_hsa052200.70186975
107Bladder cancer_Homo sapiens_hsa052190.69463763
108Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69281515
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.69100094
110Leishmaniasis_Homo sapiens_hsa051400.66921161
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66100011
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64547915
113Amoebiasis_Homo sapiens_hsa051460.63945665
114Rap1 signaling pathway_Homo sapiens_hsa040150.61464007
115Endometrial cancer_Homo sapiens_hsa052130.60406939
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59950890
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.59641669
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59524119
119Inositol phosphate metabolism_Homo sapiens_hsa005620.58765411
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58040633
121Phototransduction_Homo sapiens_hsa047440.57327526
122Salmonella infection_Homo sapiens_hsa051320.57151349
123Tuberculosis_Homo sapiens_hsa051520.57062633
124Dorso-ventral axis formation_Homo sapiens_hsa043200.57013899
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55687787
126Alcoholism_Homo sapiens_hsa050340.54522891
127Axon guidance_Homo sapiens_hsa043600.54346601
128Prolactin signaling pathway_Homo sapiens_hsa049170.54124339
129Pancreatic cancer_Homo sapiens_hsa052120.53791645
130Central carbon metabolism in cancer_Homo sapiens_hsa052300.53048458
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.52647082
132Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51978758
133Thyroid cancer_Homo sapiens_hsa052160.51691589
134Renal cell carcinoma_Homo sapiens_hsa052110.51407530
135HIF-1 signaling pathway_Homo sapiens_hsa040660.50667588
136Hepatitis B_Homo sapiens_hsa051610.48931066
137Insulin resistance_Homo sapiens_hsa049310.48418901
138Prion diseases_Homo sapiens_hsa050200.48340441
139Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46911078
140Ras signaling pathway_Homo sapiens_hsa040140.46880587
141FoxO signaling pathway_Homo sapiens_hsa040680.46754678
142Prostate cancer_Homo sapiens_hsa052150.46658059
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46080600
144Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44782267
145Galactose metabolism_Homo sapiens_hsa000520.44534885
146Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44523816
147AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43880596
148Vibrio cholerae infection_Homo sapiens_hsa051100.43371599
149Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43195792
150Pentose phosphate pathway_Homo sapiens_hsa000300.43069353
151Fructose and mannose metabolism_Homo sapiens_hsa000510.42489116
152Insulin signaling pathway_Homo sapiens_hsa049100.40375814
153Cardiac muscle contraction_Homo sapiens_hsa042600.39966657

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