SH3BP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.53228672
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.53228672
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.53228672
4modulation by symbiont of host immune response (GO:0052553)6.53228672
5positive regulation by symbiont of host defense response (GO:0052509)6.53228672
6modulation by symbiont of host defense response (GO:0052031)6.53228672
7regulation of interferon-beta biosynthetic process (GO:0045357)5.54622496
8macrophage activation involved in immune response (GO:0002281)4.83143983
9detection of other organism (GO:0098543)4.75878625
10positive regulation of interferon-alpha production (GO:0032727)4.66479396
11detection of bacterium (GO:0016045)4.61762989
12positive regulation of gamma-delta T cell activation (GO:0046645)4.58816024
13regulation of interferon-alpha production (GO:0032647)4.45081778
14response to peptidoglycan (GO:0032494)4.42490814
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.39419858
16neutrophil activation involved in immune response (GO:0002283)4.32999794
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.29788511
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.29788511
19positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.29550566
20response to host immune response (GO:0052572)4.26164054
21response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.26164054
22immunoglobulin mediated immune response (GO:0016064)4.16096181
23antigen processing and presentation of endogenous antigen (GO:0019883)4.11329761
24detection of external biotic stimulus (GO:0098581)4.07747593
25response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.03363440
26response to host (GO:0075136)4.03363440
27response to host defenses (GO:0052200)4.03363440
28regulation of B cell receptor signaling pathway (GO:0050855)3.88007754
29positive regulation of antigen processing and presentation (GO:0002579)3.77403791
30negative regulation of cell killing (GO:0031342)3.72921851
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.72921851
32microglial cell activation (GO:0001774)3.71120985
33negative regulation of lymphocyte mediated immunity (GO:0002707)3.69016759
34detection of biotic stimulus (GO:0009595)3.68388102
35response to muramyl dipeptide (GO:0032495)3.61030730
36respiratory burst (GO:0045730)3.57633649
37positive regulation of B cell differentiation (GO:0045579)3.55503848
38negative regulation of interleukin-12 production (GO:0032695)3.54400601
39negative regulation of erythrocyte differentiation (GO:0045647)3.45937958
40positive regulation of interferon-beta production (GO:0032728)3.43149039
41regulation of interleukin-12 biosynthetic process (GO:0045075)3.41653534
42I-kappaB phosphorylation (GO:0007252)3.40792537
43negative regulation of T cell mediated immunity (GO:0002710)3.39645337
44negative regulation of leukocyte mediated immunity (GO:0002704)3.34270183
45regulation of myeloid leukocyte mediated immunity (GO:0002886)3.33810129
46myeloid cell activation involved in immune response (GO:0002275)3.31128412
47macrophage activation (GO:0042116)3.28586927
48regulation of gamma-delta T cell activation (GO:0046643)3.20716783
49regulation of leukocyte degranulation (GO:0043300)3.20096762
50regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.19824565
51response to type I interferon (GO:0034340)3.16845013
52natural killer cell mediated cytotoxicity (GO:0042267)3.16333101
53natural killer cell mediated immunity (GO:0002228)3.16333101
54type I interferon signaling pathway (GO:0060337)3.15654426
55cellular response to type I interferon (GO:0071357)3.15654426
56granulocyte activation (GO:0036230)3.15444235
57production of molecular mediator involved in inflammatory response (GO:0002532)3.15393562
58negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.13818133
59T-helper 1 type immune response (GO:0042088)3.12253917
60regulation of cholesterol storage (GO:0010885)3.10704687
61neutrophil activation (GO:0042119)3.10119808
62regulation of antigen processing and presentation (GO:0002577)3.09356980
63regulation of interleukin-8 biosynthetic process (GO:0045414)3.08610465
64leukocyte migration involved in inflammatory response (GO:0002523)3.07472939
65regulation of T cell tolerance induction (GO:0002664)3.06158333
66positive regulation of mast cell degranulation (GO:0043306)3.05384276
67positive regulation of mast cell activation involved in immune response (GO:0033008)3.05384276
68defense response to protozoan (GO:0042832)3.05042358
69regulation of gamma-delta T cell differentiation (GO:0045586)3.04114050
70regulation of T-helper 2 cell differentiation (GO:0045628)3.02465349
71regulation of dendritic cell antigen processing and presentation (GO:0002604)3.01880133
72lipopolysaccharide-mediated signaling pathway (GO:0031663)2.98835461
73positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.98806428
74activated T cell proliferation (GO:0050798)2.98040207
75positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.97809394
76regulation of tolerance induction (GO:0002643)2.96953865
77pinocytosis (GO:0006907)2.94615890
78neutrophil mediated immunity (GO:0002446)2.94156143
79B cell mediated immunity (GO:0019724)2.94130805
80regulation of B cell differentiation (GO:0045577)2.92042835
81interferon-gamma-mediated signaling pathway (GO:0060333)2.91584450
82B cell receptor signaling pathway (GO:0050853)2.91499305
83germinal center formation (GO:0002467)2.91467603
84negative thymic T cell selection (GO:0045060)2.90984564
85response to interleukin-15 (GO:0070672)2.88617465
86regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.88127044
87positive regulation of cellular amide metabolic process (GO:0034250)2.87285092
88positive regulation of toll-like receptor signaling pathway (GO:0034123)2.86283653
89T cell migration (GO:0072678)2.83099256
90positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.81300642
91negative regulation of T-helper cell differentiation (GO:0045623)2.81087305
92negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.81087305
93positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.80429296
94negative T cell selection (GO:0043383)2.80339297
95apoptotic cell clearance (GO:0043277)2.80199950
96low-density lipoprotein particle clearance (GO:0034383)2.80028237
97positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.79816033
98regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.79056187
99NIK/NF-kappaB signaling (GO:0038061)2.78300759
100regulation of mast cell degranulation (GO:0043304)2.77711837
101negative regulation of alpha-beta T cell activation (GO:0046636)2.77595990
102cellular extravasation (GO:0045123)2.77290444
103negative regulation of interleukin-6 production (GO:0032715)2.77117259
104detection of molecule of bacterial origin (GO:0032490)2.76793994
105antigen processing and presentation via MHC class Ib (GO:0002475)2.76381092
106positive regulation of type 2 immune response (GO:0002830)2.75676932
107T cell selection (GO:0045058)2.75395547
108regulation of mononuclear cell migration (GO:0071675)2.74904220
109negative regulation of granulocyte differentiation (GO:0030853)2.74073680
110response to protozoan (GO:0001562)2.73288291
111response to interferon-alpha (GO:0035455)2.72374085
112positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.70490872
113positive T cell selection (GO:0043368)2.69733454
114negative regulation of toll-like receptor signaling pathway (GO:0034122)2.69523989
115regulation of natural killer cell mediated immunity (GO:0002715)2.69182311
116negative regulation of cytokine production involved in immune response (GO:0002719)2.68652714
117leukocyte aggregation (GO:0070486)2.67507553
118regulation of interferon-beta production (GO:0032648)2.67157590
119negative regulation of lipid storage (GO:0010888)2.67009554
120JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.66913586
121regulation of mast cell activation involved in immune response (GO:0033006)2.63173028
122positive regulation of humoral immune response (GO:0002922)2.60881070
123positive regulation of mast cell activation (GO:0033005)2.59095369
124myeloid dendritic cell differentiation (GO:0043011)2.57407998
125leukocyte mediated cytotoxicity (GO:0001909)2.57222943
126regulation of toll-like receptor signaling pathway (GO:0034121)2.55394236
127myeloid dendritic cell activation (GO:0001773)2.53241023
128regulation of type I interferon-mediated signaling pathway (GO:0060338)2.52962050
129regulation of interleukin-12 production (GO:0032655)2.52838040
130regulation of mast cell activation (GO:0033003)2.52033193
131positive thymic T cell selection (GO:0045059)2.51722273
132hydrogen peroxide biosynthetic process (GO:0050665)2.50467013
133myeloid leukocyte activation (GO:0002274)2.50244650
134positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.50099680
135adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.49814734
136positive regulation of chemokine biosynthetic process (GO:0045080)2.49550599

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.50868344
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.38658692
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.31891423
4* IRF8_27001747_Chip-Seq_BMDM_Mouse3.91804312
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.89501071
6NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.46896966
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.37378777
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.20427905
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.14521918
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.06157349
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.94510022
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.94160495
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.84260924
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.83832074
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.73933847
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.60067277
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.38940089
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.37223362
19VDR_21846776_ChIP-Seq_THP-1_Human2.37035580
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.36505131
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.32834641
22SCL_19346495_ChIP-Seq_HPC-7_Human2.30165081
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.28409837
24MYC_22102868_ChIP-Seq_BL_Human2.07897311
25RXR_22158963_ChIP-Seq_LIVER_Mouse2.06382168
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.03427935
27VDR_24763502_ChIP-Seq_THP-1_Human2.00208004
28PPARA_22158963_ChIP-Seq_LIVER_Mouse1.99007369
29* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.97516067
30SPI1_23127762_ChIP-Seq_K562_Human1.93908405
31PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.93471348
32MAF_26560356_Chip-Seq_TH1_Human1.91613208
33* SPI1_23547873_ChIP-Seq_NB4_Human1.89872275
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.81519431
35TCF7_22412390_ChIP-Seq_EML_Mouse1.80273839
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.78311106
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.78172625
38LXR_22158963_ChIP-Seq_LIVER_Mouse1.76607772
39RUNX_20019798_ChIP-Seq_JUKART_Human1.72577645
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.72434235
41* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.72322356
42MYB_26560356_Chip-Seq_TH2_Human1.70434281
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.68457209
44PU_27001747_Chip-Seq_BMDM_Mouse1.67264373
45CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.65853050
46MYB_26560356_Chip-Seq_TH1_Human1.64183731
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61952050
48UTX_26944678_Chip-Seq_JUKART_Human1.54771251
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.48684502
50* ELK3_25401928_ChIP-Seq_HUVEC_Human1.48069743
51* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47479690
52* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47201528
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45751620
54VDR_24787735_ChIP-Seq_THP-1_Human1.44009063
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42692294
56EGR1_23403033_ChIP-Seq_LIVER_Mouse1.42138768
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39230738
58* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.36497798
59STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35389321
60KDM2B_26808549_Chip-Seq_DND41_Human1.32740555
61* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32118642
62FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.31983254
63* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31922313
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27307265
65GATA1_22025678_ChIP-Seq_K562_Human1.26695559
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25947083
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.24822387
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23112858
69KDM2B_26808549_Chip-Seq_JURKAT_Human1.23101445
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.22544898
71PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22252418
72VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.20011669
73SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18595664
74MAF_26560356_Chip-Seq_TH2_Human1.18193510
75CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16523010
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15649195
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.12574270
78* GATA3_27048872_Chip-Seq_THYMUS_Human1.11560090
79* LXR_22292898_ChIP-Seq_THP-1_Human1.11197101
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10601314
81CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09962607
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08765874
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07300478
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06970443
85CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06838421
86CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05792045
87BCL6_27268052_Chip-Seq_Bcells_Human1.05183774
88LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.03412559
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02600842
90DROSHA_22980978_ChIP-Seq_HELA_Human1.01363270
91TP63_17297297_ChIP-ChIP_HaCaT_Human1.00540504
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97948404
93BCOR_27268052_Chip-Seq_Bcells_Human0.97602431
94KDM2B_26808549_Chip-Seq_K562_Human0.97331541
95GATA3_26560356_Chip-Seq_TH2_Human0.95304515
96GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94489256
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93969388
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93884624
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93665650
100GATA2_19941826_ChIP-Seq_K562_Human0.90608970
101GATA1_19941826_ChIP-Seq_K562_Human0.89372993
102ESR2_21235772_ChIP-Seq_MCF-7_Human0.87341940
103FOXO3_23340844_ChIP-Seq_DLD1_Human0.87293456
104NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.86132589
105TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83947578
106CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83870650
107GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83754555
108SA1_27219007_Chip-Seq_ERYTHROID_Human0.82790072
109TFEB_21752829_ChIP-Seq_HELA_Human0.82742492
110PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.82450756
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.82021857
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81393123
113RARG_19884340_ChIP-ChIP_MEFs_Mouse0.80382217
114NCOR1_26117541_ChIP-Seq_K562_Human0.79246400
115PU.1_20513432_ChIP-Seq_Bcells_Mouse0.79060494
116* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.78839977
117BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78035805
118GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77821941
119* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.76226389
120RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.76191453
121CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.75904554

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.77419499
2MP0003303_peritoneal_inflammation3.70296689
3MP0005058_abnormal_lysosome_morphology3.56528845
4MP0003436_decreased_susceptibility_to3.43096679
5MP0000569_abnormal_digit_pigmentation2.97653241
6MP0009840_abnormal_foam_cell2.80614591
7* MP0002419_abnormal_innate_immunity2.79537865
8MP0001790_abnormal_immune_system2.75275614
9MP0005387_immune_system_phenotype2.75275614
10MP0003172_abnormal_lysosome_physiology2.64228604
11MP0005000_abnormal_immune_tolerance2.62406468
12* MP0001800_abnormal_humoral_immune2.58344867
13MP0000685_abnormal_immune_system2.56569882
14MP0009785_altered_susceptibility_to2.54623265
15* MP0002452_abnormal_antigen_presenting2.49217982
16MP0005025_abnormal_response_to2.47022743
17MP0005464_abnormal_platelet_physiology2.35235373
18* MP0002723_abnormal_immune_serum2.30995514
19MP0003191_abnormal_cellular_cholesterol2.29692561
20MP0003300_gastrointestinal_ulcer2.27314213
21* MP0006082_CNS_inflammation2.17225240
22MP0002148_abnormal_hypersensitivity_rea2.12454435
23MP0005671_abnormal_response_to2.12372820
24* MP0001819_abnormal_immune_cell2.05565928
25* MP0002420_abnormal_adaptive_immunity2.04748909
26MP0009278_abnormal_bone_marrow2.02435402
27MP0003724_increased_susceptibility_to1.89095029
28MP0003828_pulmonary_edema1.81221966
29* MP0004947_skin_inflammation1.76686761
30* MP0001845_abnormal_inflammatory_respons1.71012859
31* MP0001533_abnormal_skeleton_physiology1.70431504
32MP0005360_urolithiasis1.70416977
33MP0000604_amyloidosis1.66876117
34* MP0002405_respiratory_system_inflammati1.64475686
35* MP0008469_abnormal_protein_level1.61240076
36* MP0000716_abnormal_immune_system1.61218036
37* MP0002398_abnormal_bone_marrow1.57012872
38* MP0000689_abnormal_spleen_morphology1.55009492
39MP0002139_abnormal_hepatobiliary_system1.54328458
40MP0002166_altered_tumor_susceptibility1.53797902
41MP0001853_heart_inflammation1.53148088
42MP0003448_altered_tumor_morphology1.45027269
43MP0002254_reproductive_system_inflammat1.44135901
44MP0004883_abnormal_blood_vessel1.43939891
45MP0003183_abnormal_peptide_metabolism1.43714286
46MP0010155_abnormal_intestine_physiology1.42048040
47* MP0004510_myositis1.40275195
48MP0003866_abnormal_defecation1.36889509
49MP0009764_decreased_sensitivity_to1.36023624
50MP0005257_abnormal_intraocular_pressure1.35358529
51MP0005174_abnormal_tail_pigmentation1.34687502
52MP0009333_abnormal_splenocyte_physiolog1.33423665
53* MP0002429_abnormal_blood_cell1.32889898
54* MP0002722_abnormal_immune_system1.32574894
55MP0001545_abnormal_hematopoietic_system1.30773681
56MP0005397_hematopoietic_system_phenotyp1.30773681
57MP0003705_abnormal_hypodermis_morpholog1.29892405
58MP0003075_altered_response_to1.28566987
59MP0002006_tumorigenesis1.28193404
60MP0000465_gastrointestinal_hemorrhage1.27314627
61MP0004381_abnormal_hair_follicle1.25360705
62MP0002396_abnormal_hematopoietic_system1.24602738
63MP0010307_abnormal_tumor_latency1.22413150
64MP0005076_abnormal_cell_differentiation1.21273968
65MP0003690_abnormal_glial_cell1.19013408
66* MP0002998_abnormal_bone_remodeling1.18763910
67MP0002132_abnormal_respiratory_system1.16876249
68MP0000343_altered_response_to1.16729081
69MP0003566_abnormal_cell_adhesion1.15674481
70MP0005310_abnormal_salivary_gland1.15364630
71MP0003656_abnormal_erythrocyte_physiolo1.12871057
72MP0002277_abnormal_respiratory_mucosa1.11799176
73* MP0000609_abnormal_liver_physiology1.09363696
74MP0005083_abnormal_biliary_tract1.08946561
75MP0002138_abnormal_hepatobiliary_system1.08539342
76MP0009763_increased_sensitivity_to1.06614943
77MP0005166_decreased_susceptibility_to1.04027345
78MP0005365_abnormal_bile_salt1.03638923
79* MP0001851_eye_inflammation1.03166833
80MP0003252_abnormal_bile_duct1.01508742
81MP0000858_altered_metastatic_potential1.01219045
82MP0005167_abnormal_blood-brain_barrier0.99052637
83MP0004808_abnormal_hematopoietic_stem0.96852618
84MP0003763_abnormal_thymus_physiology0.92894483
85MP0005451_abnormal_body_composition0.92648308
86MP0010329_abnormal_lipoprotein_level0.89973120
87* MP0001663_abnormal_digestive_system0.89281578
88MP0003453_abnormal_keratinocyte_physiol0.88070641
89MP0005023_abnormal_wound_healing0.87827098
90MP0008004_abnormal_stomach_pH0.87748260
91MP0004130_abnormal_muscle_cell0.87697457
92MP0008875_abnormal_xenobiotic_pharmacok0.86158529
93MP0003045_fibrosis0.85803347
94MP0003091_abnormal_cell_migration0.83858850
95MP0000371_diluted_coat_color0.82426125
96MP0000598_abnormal_liver_morphology0.81938613
97MP0000703_abnormal_thymus_morphology0.79685253
98* MP0002933_joint_inflammation0.79591368
99MP0002136_abnormal_kidney_physiology0.78923161
100* MP0001873_stomach_inflammation0.78791768
101MP0000767_abnormal_smooth_muscle0.77328391
102MP0008260_abnormal_autophagy0.75856039
103* MP0005390_skeleton_phenotype0.75532663
104MP0000249_abnormal_blood_vessel0.74373080
105MP0005085_abnormal_gallbladder_physiolo0.73250905
106MP0002009_preneoplasia0.73026577
107MP0001958_emphysema0.72526470
108MP0000490_abnormal_crypts_of0.71074175
109MP0002332_abnormal_exercise_endurance0.69990434
110MP0009765_abnormal_xenobiotic_induced0.69540140
111MP0003279_aneurysm0.68838481
112MP0000015_abnormal_ear_pigmentation0.68618703
113MP0001915_intracranial_hemorrhage0.68025613
114MP0001986_abnormal_taste_sensitivity0.67605068
115MP0005164_abnormal_response_to0.66675733
116* MP0005319_abnormal_enzyme/_coenzyme0.66234090
117* MP0003795_abnormal_bone_structure0.65275626
118MP0009115_abnormal_fat_cell0.64827596
119MP0003879_abnormal_hair_cell0.60518671
120MP0008874_decreased_physiological_sensi0.58570319
121MP0002693_abnormal_pancreas_physiology0.52064056
122* MP0005381_digestive/alimentary_phenotyp0.50442152

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.85354365
2Recurrent bacterial skin infections (HP:0005406)5.55731810
3Eczematoid dermatitis (HP:0000976)5.22916895
4Recurrent gram-negative bacterial infections (HP:0005420)4.99911832
5Systemic lupus erythematosus (HP:0002725)4.71269421
6Increased cerebral lipofuscin (HP:0011813)4.44554853
7Abnormality of macrophages (HP:0004311)4.11988187
8Vacuolated lymphocytes (HP:0001922)4.04146989
9Increased IgE level (HP:0003212)3.70880858
10Increased neuronal autofluorescent lipopigment (HP:0002074)3.67674088
11Glomerulonephritis (HP:0000099)3.65449487
12Recurrent skin infections (HP:0001581)3.62480918
13Gastrointestinal infarctions (HP:0005244)3.55121374
14Elevated erythrocyte sedimentation rate (HP:0003565)3.53022441
15Myositis (HP:0100614)3.48973029
16Myocardial infarction (HP:0001658)3.46574690
17Autoimmune thrombocytopenia (HP:0001973)3.44636778
18Keratoconjunctivitis sicca (HP:0001097)3.41896718
19Mediastinal lymphadenopathy (HP:0100721)3.39609207
20Dysostosis multiplex (HP:0000943)3.33366578
21Disinhibition (HP:0000734)3.28825325
22Recurrent fungal infections (HP:0002841)3.28243303
23Complement deficiency (HP:0004431)3.21343189
24Gingivitis (HP:0000230)3.20914923
25Encephalitis (HP:0002383)3.17653602
26Keratoconjunctivitis (HP:0001096)3.14838717
27Abnormality of glycolipid metabolism (HP:0010969)3.12244033
28Abnormality of liposaccharide metabolism (HP:0010968)3.12244033
29Abnormality of glycosphingolipid metabolism (HP:0004343)3.12244033
30Orchitis (HP:0100796)3.11226096
31Axonal loss (HP:0003447)3.09190748
32Hemoptysis (HP:0002105)3.05744178
33Periodontitis (HP:0000704)3.02263742
34Colitis (HP:0002583)3.02212075
35Stomatitis (HP:0010280)2.98708577
36Recurrent viral infections (HP:0004429)2.94083378
37Abnormality of T cell number (HP:0011839)2.92983651
38Mucopolysacchariduria (HP:0008155)2.92708338
39Urinary glycosaminoglycan excretion (HP:0003541)2.92708338
40Abnormality of glycosaminoglycan metabolism (HP:0004371)2.92036642
41Abnormality of mucopolysaccharide metabolism (HP:0011020)2.92036642
42Abnormality of polysaccharide metabolism (HP:0011012)2.92036642
43Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.90951462
44Joint hemorrhage (HP:0005261)2.88516609
45Hypochromic anemia (HP:0001931)2.85357563
46Abnormality of complement system (HP:0005339)2.85190637
47Gingival bleeding (HP:0000225)2.84132800
48Pustule (HP:0200039)2.83388581
49Vasculitis (HP:0002633)2.82475974
50Cellulitis (HP:0100658)2.80062426
51Hematochezia (HP:0002573)2.75648415
52Loss of speech (HP:0002371)2.75498285
53Chronic obstructive pulmonary disease (HP:0006510)2.71666914
54Obstructive lung disease (HP:0006536)2.71666914
55Optic neuritis (HP:0100653)2.70592601
56Retrobulbar optic neuritis (HP:0100654)2.70592601
57T lymphocytopenia (HP:0005403)2.63645632
58Chest pain (HP:0100749)2.63639943
59Inflammation of the large intestine (HP:0002037)2.63179910
60Increased IgM level (HP:0003496)2.63003984
61Chronic otitis media (HP:0000389)2.57702555
62Nephritis (HP:0000123)2.56203250
63Pulmonary embolism (HP:0002204)2.53566315
64Spontaneous hematomas (HP:0007420)2.50425341
65Recurrent cutaneous fungal infections (HP:0011370)2.49835326
66Chronic mucocutaneous candidiasis (HP:0002728)2.49835326
67Gastrointestinal inflammation (HP:0004386)2.48308275
68Episodic fever (HP:0001954)2.47561146
69Osteomyelitis (HP:0002754)2.44376440
70Arterial thrombosis (HP:0004420)2.42270232
71Thick nail (HP:0001805)2.42011443
72Panhypogammaglobulinemia (HP:0003139)2.40166157
73Interstitial pulmonary disease (HP:0006530)2.40018226
74Granulocytopenia (HP:0001913)2.39888310
75Urticaria (HP:0001025)2.36572827
76Gangrene (HP:0100758)2.34840937
77Meningitis (HP:0001287)2.33871473
78Upper motor neuron abnormality (HP:0002127)2.33451217
79Thoracic kyphosis (HP:0002942)2.32076295
80Abnormality of T cells (HP:0002843)2.30330585
81Impaired platelet aggregation (HP:0003540)2.30304219
82Abnormal platelet function (HP:0011869)2.30304219
83Deep venous thrombosis (HP:0002625)2.29725408
84Autoimmune hemolytic anemia (HP:0001890)2.28458295
85Peritonitis (HP:0002586)2.27558634
86Pathologic fracture (HP:0002756)2.27070553
87Basal ganglia calcification (HP:0002135)2.26546066
88Agammaglobulinemia (HP:0004432)2.26331144
89Hypochromic microcytic anemia (HP:0004840)2.24877651
90Metaphyseal cupping (HP:0003021)2.23729952
91Epistaxis (HP:0000421)2.23382001
92Hypergammaglobulinemia (HP:0010702)2.22477271
93Anorexia (HP:0002039)2.19683488
94Hepatosplenomegaly (HP:0001433)2.17609587
95Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.15860344
96Amyloidosis (HP:0011034)2.15321783
97Eosinophilia (HP:0001880)2.14752589
98Pulmonary infiltrates (HP:0002113)2.13935554
99Nasal polyposis (HP:0100582)2.13812652
100Abnormality of the pleura (HP:0002103)2.13623400
101Prostate neoplasm (HP:0100787)2.12072390
102Gastrointestinal stroma tumor (HP:0100723)2.10307758
103Leukocytosis (HP:0001974)2.09349752
104Abnormality of T cell physiology (HP:0011840)2.08559682
105Hypercholesterolemia (HP:0003124)2.08096657
106Sepsis (HP:0100806)2.05989568
107Increased serum ferritin (HP:0003281)2.05145869
108Purpura (HP:0000979)2.04325052
109Osteolytic defects of the phalanges of the hand (HP:0009771)2.02847919
110Osteolytic defects of the hand bones (HP:0009699)2.02847919
111Xanthomatosis (HP:0000991)2.02729438
112Abnormality of cells of the lymphoid lineage (HP:0012140)2.02499362
113Bone pain (HP:0002653)2.02489263
114Restrictive lung disease (HP:0002091)2.01833054
115Abnormality of the nasal mucosa (HP:0000433)2.01126250
116Premature loss of primary teeth (HP:0006323)2.01098745
117Asymmetric septal hypertrophy (HP:0001670)2.01050859
118Abnormality of iron homeostasis (HP:0011031)2.00670281
119Abnormality of the endocardium (HP:0004306)1.98921063
120Malnutrition (HP:0004395)1.98162676
121Lymphopenia (HP:0001888)1.97928489
122Prolonged bleeding time (HP:0003010)1.96748781
123Abnormality of the thoracic spine (HP:0100711)1.96745224
124Petechiae (HP:0000967)1.95752881
125Abnormal delayed hypersensitivity skin test (HP:0002963)1.95727249
126Tetraparesis (HP:0002273)1.94756210
127Abnormality of the vasculature of the conjunctiva (HP:0008054)1.94733026
128Recurrent pneumonia (HP:0006532)1.92937479
129Acne (HP:0001061)1.92643280
130Mitral stenosis (HP:0001718)1.92561237
131Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.89982125
132Vertigo (HP:0002321)1.89578343
133IgM deficiency (HP:0002850)1.88810189
134Emphysema (HP:0002097)1.88110809
135Peripheral demyelination (HP:0011096)1.87914459
136Menorrhagia (HP:0000132)1.87820896
137Esophageal varix (HP:0002040)1.87715951
138Conjunctival telangiectasia (HP:0000524)1.86918511
139Skin ulcer (HP:0200042)1.86657991
140Global brain atrophy (HP:0002283)1.85146589
141Abnormality of the lumbar spine (HP:0100712)1.84290347
142Abnormality of the fingertips (HP:0001211)1.84187161
143Papilloma (HP:0012740)1.81903351
144Verrucae (HP:0200043)1.81903351

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.00629017
2TYK23.19009139
3ERN13.17347412
4TBK13.01709056
5BLK2.83816937
6MAP3K142.73798263
7RIPK42.63952729
8TRIB32.59169987
9PRPF4B2.42238962
10JAK32.23816283
11MAP2K32.21493695
12IRAK42.21046858
13TAOK32.17543053
14IKBKE2.15445277
15TNK22.11953516
16TGFBR22.10761878
17CSF1R2.00125157
18JAK11.97543841
19IRAK31.97303533
20ZAP701.83623704
21SIK21.82639156
22IKBKB1.82291616
23MAP3K131.76391159
24CAMK1D1.75152755
25EPHB11.72263404
26CDK121.65894025
27CSK1.65331900
28MAP3K31.64273579
29HCK1.56951818
30STK101.53872625
31FGFR41.50212640
32PKN21.48420670
33MAP3K101.39889523
34FES1.38483361
35CAMK1G1.34353384
36BTK1.32111921
37PTK61.29077741
38CHUK1.27873688
39TXK1.23793649
40TTN1.20713706
41* KIT1.17992599
42* SYK1.15182700
43RPS6KA41.12882307
44NEK91.11619993
45CDC42BPA1.11389261
46JAK21.11158528
47LCK1.10506688
48GRK71.09910857
49FGR1.09704142
50MARK21.07038238
51MAPK71.01701458
52LYN1.01605821
53IRAK10.95392386
54MAP3K70.94037550
55SIK10.93946211
56LRRK20.92942650
57MAP3K60.91279116
58PRKD20.91003778
59EEF2K0.90292743
60GRK60.90275880
61CDK60.88563061
62PIM10.87332020
63FGFR30.85853468
64YES10.85796509
65MAP3K110.85157250
66SIK30.81731844
67ITK0.81481920
68RIPK10.80472517
69CAMKK20.77548925
70IRAK20.76833071
71TAOK10.76353148
72BMX0.74345404
73MATK0.72994457
74TAOK20.71356940
75MARK30.70839111
76RET0.70482028
77MAP2K60.70406235
78TEC0.69402059
79BMPR20.68143810
80SGK30.66736981
81ABL10.65389079
82CAMKK10.63930701
83RPS6KL10.62165176
84RPS6KC10.62165176
85HIPK20.60867294
86* EGFR0.60027748
87PRKCH0.59166303
88PIM20.58793142
89CDK190.58690533
90MOS0.58111534
91NME20.57967620
92EPHA30.54451996
93ABL20.51368962
94STK110.51295301
95TLK10.50979565
96PIK3CG0.50966322
97NLK0.50842602
98PAK40.50598189
99CDK90.49170219
100STK30.45705091
101KSR20.45090761
102FRK0.44262489
103CLK10.44134956
104MST1R0.42282775
105RPS6KA20.41168420
106PTK2B0.40664161
107DAPK20.40258530
108PDK10.40192016
109CDK40.39951865
110TRPM70.38656276
111MTOR0.38200735
112MAPK110.37031529
113PDPK10.36930433
114FYN0.36550292
115MAP3K50.36228484
116PRKAA20.35308602
117MAPK120.35094803
118MAP3K10.35083493
119PRKCD0.34530056
120MAP3K80.34118369
121CAMK40.33365247
122MAP2K40.32623415
123RPS6KA60.32184998
124MAPK40.32106340
125NEK20.31167969
126GSK3A0.30946269
127MAPKAPK20.30867362
128PDGFRB0.30180200
129STK40.30101497
130ALK0.30064318
131SGK20.29612734
132PRKCQ0.29401841
133ERBB40.28831901

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.84111481
2Leishmaniasis_Homo sapiens_hsa051402.95529593
3Osteoclast differentiation_Homo sapiens_hsa043802.51251850
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.49419774
5B cell receptor signaling pathway_Homo sapiens_hsa046622.45160746
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.39663539
7Autoimmune thyroid disease_Homo sapiens_hsa053202.28428358
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.24989484
9Caffeine metabolism_Homo sapiens_hsa002322.16090685
10Lysosome_Homo sapiens_hsa041422.13224986
11Complement and coagulation cascades_Homo sapiens_hsa046102.03791087
12Tuberculosis_Homo sapiens_hsa051521.96924663
13Pertussis_Homo sapiens_hsa051331.96480492
14Malaria_Homo sapiens_hsa051441.88632503
15Type I diabetes mellitus_Homo sapiens_hsa049401.83552969
16Measles_Homo sapiens_hsa051621.83124113
17Other glycan degradation_Homo sapiens_hsa005111.80500503
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.74765505
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.71723176
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.69050788
21Influenza A_Homo sapiens_hsa051641.61567586
22Legionellosis_Homo sapiens_hsa051341.59634979
23Toxoplasmosis_Homo sapiens_hsa051451.58249836
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.52688506
25TNF signaling pathway_Homo sapiens_hsa046681.45666604
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.44486492
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.41808195
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39346057
29Antigen processing and presentation_Homo sapiens_hsa046121.37382343
30Hematopoietic cell lineage_Homo sapiens_hsa046401.34136559
31Apoptosis_Homo sapiens_hsa042101.32176069
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30007712
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.28543324
34Herpes simplex infection_Homo sapiens_hsa051681.23690672
35Shigellosis_Homo sapiens_hsa051311.23651232
36Chronic myeloid leukemia_Homo sapiens_hsa052201.23429531
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.23382624
38* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22896947
39Primary immunodeficiency_Homo sapiens_hsa053401.22062995
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.19449146
41Chemokine signaling pathway_Homo sapiens_hsa040621.19356258
42Phagosome_Homo sapiens_hsa041451.19262060
43Hepatitis B_Homo sapiens_hsa051611.13441030
44Graft-versus-host disease_Homo sapiens_hsa053321.12430646
45Acute myeloid leukemia_Homo sapiens_hsa052211.12308327
46Allograft rejection_Homo sapiens_hsa053301.09005118
47Salmonella infection_Homo sapiens_hsa051321.08388033
48Pancreatic cancer_Homo sapiens_hsa052121.08198749
49Hepatitis C_Homo sapiens_hsa051601.08031457
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07259169
51T cell receptor signaling pathway_Homo sapiens_hsa046601.04563640
52Rheumatoid arthritis_Homo sapiens_hsa053231.03845804
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99557446
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98547015
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.90904947
56Dorso-ventral axis formation_Homo sapiens_hsa043200.86744086
57Asthma_Homo sapiens_hsa053100.86002395
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83571689
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83018421
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82489700
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82349500
62Arginine biosynthesis_Homo sapiens_hsa002200.82145060
63Viral myocarditis_Homo sapiens_hsa054160.81638385
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.79010984
65Lysine degradation_Homo sapiens_hsa003100.78438623
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78269863
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.77199926
68Amoebiasis_Homo sapiens_hsa051460.76711226
69Prolactin signaling pathway_Homo sapiens_hsa049170.74416843
70African trypanosomiasis_Homo sapiens_hsa051430.73713116
71Platelet activation_Homo sapiens_hsa046110.73482487
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73341310
73Nitrogen metabolism_Homo sapiens_hsa009100.72481522
74FoxO signaling pathway_Homo sapiens_hsa040680.69630695
75Choline metabolism in cancer_Homo sapiens_hsa052310.69359856
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.68337514
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67678701
78Small cell lung cancer_Homo sapiens_hsa052220.66242689
79GnRH signaling pathway_Homo sapiens_hsa049120.65416352
80Notch signaling pathway_Homo sapiens_hsa043300.65276274
81ABC transporters_Homo sapiens_hsa020100.63482255
82Selenocompound metabolism_Homo sapiens_hsa004500.61006268
83Insulin resistance_Homo sapiens_hsa049310.60645254
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59421796
85VEGF signaling pathway_Homo sapiens_hsa043700.59072628
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57303972
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53956321
88Prion diseases_Homo sapiens_hsa050200.53769687
89Non-small cell lung cancer_Homo sapiens_hsa052230.52464038
90MAPK signaling pathway_Homo sapiens_hsa040100.51543278
91PPAR signaling pathway_Homo sapiens_hsa033200.51094415
92Epstein-Barr virus infection_Homo sapiens_hsa051690.49736768
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.48378988
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46585927
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.44953126
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44183326
97Endometrial cancer_Homo sapiens_hsa052130.44153360
98Rap1 signaling pathway_Homo sapiens_hsa040150.43740029
99Histidine metabolism_Homo sapiens_hsa003400.42837895
100Estrogen signaling pathway_Homo sapiens_hsa049150.41226143
101Type II diabetes mellitus_Homo sapiens_hsa049300.41039427
102MicroRNAs in cancer_Homo sapiens_hsa052060.40683351
103Tryptophan metabolism_Homo sapiens_hsa003800.40360949
104Viral carcinogenesis_Homo sapiens_hsa052030.40328781
105Proteoglycans in cancer_Homo sapiens_hsa052050.39551000
106Bladder cancer_Homo sapiens_hsa052190.38408947
107HIF-1 signaling pathway_Homo sapiens_hsa040660.38299493
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.38287434
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37979057
110Colorectal cancer_Homo sapiens_hsa052100.37539031
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36956978
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36761078
113ErbB signaling pathway_Homo sapiens_hsa040120.36720982
114Endocytosis_Homo sapiens_hsa041440.36325455
115HTLV-I infection_Homo sapiens_hsa051660.36205911
116mTOR signaling pathway_Homo sapiens_hsa041500.34975557
117Renal cell carcinoma_Homo sapiens_hsa052110.34940317
118Inositol phosphate metabolism_Homo sapiens_hsa005620.34862203
119Starch and sucrose metabolism_Homo sapiens_hsa005000.34498874
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34183410
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32706283
122Prostate cancer_Homo sapiens_hsa052150.32626432
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31333264
124Ras signaling pathway_Homo sapiens_hsa040140.31155681

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