SH3BP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polarized epithelial cell differentiation (GO:0030859)4.89525835
2positive regulation of SMAD protein import into nucleus (GO:0060391)4.40556038
3regulation of hippo signaling (GO:0035330)4.35080294
4skin morphogenesis (GO:0043589)4.26314594
5regulation of SMAD protein import into nucleus (GO:0060390)4.06653205
6paraxial mesoderm development (GO:0048339)3.85922573
7regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.80083020
8protein retention in ER lumen (GO:0006621)3.79042997
9hippo signaling (GO:0035329)3.77738504
10regulation of gene silencing by RNA (GO:0060966)3.77453103
11regulation of posttranscriptional gene silencing (GO:0060147)3.77453103
12regulation of gene silencing by miRNA (GO:0060964)3.77453103
13maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.76703757
14establishment of apical/basal cell polarity (GO:0035089)3.76238927
15dermatan sulfate biosynthetic process (GO:0030208)3.62552168
16collagen fibril organization (GO:0030199)3.61710889
17respiratory tube development (GO:0030323)3.60760916
18pattern specification involved in kidney development (GO:0061004)3.52003017
19collecting duct development (GO:0072044)3.47925492
20regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.37763556
21morphogenesis of an endothelium (GO:0003159)3.36179537
22endothelial tube morphogenesis (GO:0061154)3.36179537
23glomerular visceral epithelial cell development (GO:0072015)3.27243897
24establishment of monopolar cell polarity (GO:0061162)3.26805975
25establishment or maintenance of monopolar cell polarity (GO:0061339)3.26805975
26vascular endothelial growth factor signaling pathway (GO:0038084)3.25877013
27response to hepatocyte growth factor (GO:0035728)3.22007629
28cellular response to hepatocyte growth factor stimulus (GO:0035729)3.22007629
29astrocyte differentiation (GO:0048708)3.19316267
30endocardial cushion development (GO:0003197)3.18256385
31planar cell polarity pathway involved in neural tube closure (GO:0090179)3.14035745
32dermatan sulfate metabolic process (GO:0030205)3.12983969
33Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.10227796
34cochlea morphogenesis (GO:0090103)3.09424257
35mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.07482902
36epithelial cell-cell adhesion (GO:0090136)3.06174787
37kidney mesenchyme development (GO:0072074)3.05696997
38G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.04906332
39regulation of catenin import into nucleus (GO:0035412)3.03439062
40dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.03093330
41glomerular epithelial cell development (GO:0072310)3.02780061
42anterior/posterior axis specification, embryo (GO:0008595)3.00732937
43lung morphogenesis (GO:0060425)3.00711803
44regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.00105977
45regulation of establishment of planar polarity (GO:0090175)2.99523786
46positive regulation of catenin import into nucleus (GO:0035413)2.96943128
47positive regulation of actin filament depolymerization (GO:0030836)2.96015668
48regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.93375775
49mesenchymal-epithelial cell signaling (GO:0060638)2.92472571
50plasma membrane repair (GO:0001778)2.92161167
51focal adhesion assembly (GO:0048041)2.89049684
52cell-substrate adherens junction assembly (GO:0007045)2.89049684
53bone trabecula formation (GO:0060346)2.87916793
54protein heterotrimerization (GO:0070208)2.86725648
55substrate-dependent cell migration (GO:0006929)2.85730977
56renal filtration (GO:0097205)2.84763787
57embryonic foregut morphogenesis (GO:0048617)2.84286781
58regulation of plasminogen activation (GO:0010755)2.83459468
59ectodermal placode formation (GO:0060788)2.83326880
60regulation of heart morphogenesis (GO:2000826)2.82453767
61negative regulation of catenin import into nucleus (GO:0035414)2.80712533
62convergent extension (GO:0060026)2.80582371
63glomerular basement membrane development (GO:0032836)2.79908610
64adherens junction assembly (GO:0034333)2.79186242
65renal system development (GO:0072001)2.77734359
66hemidesmosome assembly (GO:0031581)2.75617150
67positive regulation of p38MAPK cascade (GO:1900745)2.74639026
68negative regulation of chondrocyte differentiation (GO:0032331)2.74163979
69cell surface receptor signaling pathway involved in heart development (GO:0061311)2.72309639
70cytoskeletal anchoring at plasma membrane (GO:0007016)2.72188506
71semaphorin-plexin signaling pathway (GO:0071526)2.70513867
72peptidyl-proline hydroxylation (GO:0019511)2.69404396
73desmosome organization (GO:0002934)2.68987489
74branching involved in salivary gland morphogenesis (GO:0060445)2.68732702
75positive regulation of osteoblast proliferation (GO:0033690)2.68582171
76collagen metabolic process (GO:0032963)2.65624542
77basement membrane organization (GO:0071711)2.65268714
78establishment of epithelial cell polarity (GO:0090162)2.64210144
79mesodermal cell differentiation (GO:0048333)2.63634271
80negative regulation of fibrinolysis (GO:0051918)2.63625269
81wound healing, spreading of epidermal cells (GO:0035313)2.62172892
82regulation of p38MAPK cascade (GO:1900744)2.62005673
83metanephric mesenchyme development (GO:0072075)2.60679647
84establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.58795617
85growth hormone receptor signaling pathway (GO:0060396)2.58381214
86cellular response to vitamin D (GO:0071305)2.57832326
87regulation of cardioblast differentiation (GO:0051890)2.57665800
88locomotory exploration behavior (GO:0035641)2.57471014
89regulation of cell fate specification (GO:0042659)2.56603453
90positive regulation of endothelial cell differentiation (GO:0045603)2.56460583
91positive regulation of blood vessel endothelial cell migration (GO:0043536)2.55923403
92cell junction maintenance (GO:0034331)2.55300284
93cell adhesion mediated by integrin (GO:0033627)2.55290331
94craniofacial suture morphogenesis (GO:0097094)2.54562899
95negative regulation of cartilage development (GO:0061037)2.54282792
96establishment of tissue polarity (GO:0007164)2.54059591
97establishment of planar polarity (GO:0001736)2.54059591
98protein hydroxylation (GO:0018126)2.53547615
99regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.52997238
100substrate adhesion-dependent cell spreading (GO:0034446)2.52676207
101blood vessel endothelial cell migration (GO:0043534)2.52418172
102lung-associated mesenchyme development (GO:0060484)2.51830731
103heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.51673337
104lymphangiogenesis (GO:0001946)2.51139855
105cell migration involved in sprouting angiogenesis (GO:0002042)2.50911975
106positive regulation of endothelial cell apoptotic process (GO:2000353)2.50653358
107retina vasculature morphogenesis in camera-type eye (GO:0061299)2.50233111
108multicellular organismal macromolecule metabolic process (GO:0044259)2.50071926
109adherens junction organization (GO:0034332)2.49608145
110muscle cell migration (GO:0014812)2.48979725
111ectoderm development (GO:0007398)2.48909920
112extracellular matrix disassembly (GO:0022617)2.48488501
113regulation of endothelial cell differentiation (GO:0045601)2.47974687
114protein localization to endosome (GO:0036010)2.47056885
115protein carboxylation (GO:0018214)2.47000862
116peptidyl-glutamic acid carboxylation (GO:0017187)2.47000862
117establishment or maintenance of bipolar cell polarity (GO:0061245)2.46657191
118establishment or maintenance of apical/basal cell polarity (GO:0035088)2.46657191
119protein localization to cell surface (GO:0034394)2.46425030
120cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.46388031
121wound healing, spreading of cells (GO:0044319)2.45931637
122collagen catabolic process (GO:0030574)2.45425705
123regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.44605383
124stress fiber assembly (GO:0043149)2.44524427
125cell-substrate junction assembly (GO:0007044)2.43244013
126myelination in peripheral nervous system (GO:0022011)2.42932209
127peripheral nervous system axon ensheathment (GO:0032292)2.42932209
128cell migration involved in heart development (GO:0060973)2.42369036
129neuron projection extension involved in neuron projection guidance (GO:1902284)2.42098542
130axon extension involved in axon guidance (GO:0048846)2.42098542
131cell-cell junction maintenance (GO:0045217)2.41879235
132Golgi transport vesicle coating (GO:0048200)2.41738739
133COPI coating of Golgi vesicle (GO:0048205)2.41738739
134regulation of transforming growth factor beta2 production (GO:0032909)2.41378173
135negative regulation of osteoblast proliferation (GO:0033689)2.40614728
136type B pancreatic cell proliferation (GO:0044342)2.39594512
137sequestering of extracellular ligand from receptor (GO:0035581)2.39544436
138multicellular organismal metabolic process (GO:0044236)2.39426125
139actin filament depolymerization (GO:0030042)2.39281250
140insulin-like growth factor receptor signaling pathway (GO:0048009)2.39168139
141notochord development (GO:0030903)2.38330299
142retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.38025828
143endothelial cell morphogenesis (GO:0001886)2.37874681
144atrioventricular valve morphogenesis (GO:0003181)2.36642209
145apoptotic cell clearance (GO:0043277)2.35651304
146dorsal/ventral axis specification (GO:0009950)2.35564759
147cranial suture morphogenesis (GO:0060363)2.35133768
148negative regulation of axon extension involved in axon guidance (GO:0048843)2.35059485
149endodermal cell differentiation (GO:0035987)2.34520249
150negative regulation of fatty acid transport (GO:2000192)2.34517818
151non-canonical Wnt signaling pathway (GO:0035567)2.34465979
152camera-type eye morphogenesis (GO:0048593)2.33905765
153chondrocyte proliferation (GO:0035988)2.33282553
154apoptotic process involved in morphogenesis (GO:0060561)2.32658043
155extracellular matrix assembly (GO:0085029)2.32586861
156regulation of osteoblast proliferation (GO:0033688)2.32090789
157gap junction assembly (GO:0016264)2.31999845
158regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.31843706
159lens fiber cell development (GO:0070307)2.31283526

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.03504502
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.38722891
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.18650784
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.02140185
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.87756306
6ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.84332969
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.81928247
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.81928247
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.81928247
10NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.71101380
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.70784889
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.69497809
13CLOCK_20551151_ChIP-Seq_293T_Human2.63076192
14SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.45745853
15* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.42530509
16* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.39127356
17* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.36295654
18TCF3_18692474_ChIP-Seq_MEFs_Mouse2.32587179
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.21040729
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.20284937
21* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.19902939
22* ESR2_21235772_ChIP-Seq_MCF-7_Human2.16321375
23HIF1A_21447827_ChIP-Seq_MCF-7_Human2.10073495
24HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.08664709
25* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.97570624
26* ESR1_21235772_ChIP-Seq_MCF-7_Human1.97157685
27WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.94483340
28WT1_19549856_ChIP-ChIP_CCG9911_Human1.91883963
29TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.84437169
30* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.82863181
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.81050421
32SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.77283061
33* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.69681891
34ZNF263_19887448_ChIP-Seq_K562_Human1.69372655
35* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.64567964
36TCF3_18692474_ChIP-Seq_MESCs_Mouse1.63611158
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.62693293
38ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.61324504
39* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.59843097
40* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.59576843
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55971908
42* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.55949477
43SOX2_18555785_ChIP-Seq_MESCs_Mouse1.55183772
44SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.51973363
45* CJUN_26792858_Chip-Seq_BT549_Human1.47637132
46* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47286884
47* ELK3_25401928_ChIP-Seq_HUVEC_Human1.46949936
48DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.46939118
49NFIB_24661679_ChIP-Seq_LUNG_Mouse1.44904837
50ISL1_27105846_Chip-Seq_CPCs_Mouse1.44033006
51TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42309193
52P300_27058665_Chip-Seq_ZR-75-30cells_Human1.41037685
53FOXM1_23109430_ChIP-Seq_U2OS_Human1.40736718
54* FOXO3_23340844_ChIP-Seq_DLD1_Human1.38907660
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.37449511
56EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35334419
57KDM2B_26808549_Chip-Seq_K562_Human1.34919435
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34563507
59RACK7_27058665_Chip-Seq_MCF-7_Human1.34036887
60* BRD4_25478319_ChIP-Seq_HGPS_Human1.31448039
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.30807195
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30487773
63ATF3_27146783_Chip-Seq_COLON_Human1.29651219
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29212442
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27583204
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26252960
67ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25898127
68SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.25712064
69SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.25712064
70EZH2_18974828_ChIP-Seq_MESCs_Mouse1.24842142
71RNF2_18974828_ChIP-Seq_MESCs_Mouse1.24842142
72NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.24533050
73POU5F1_16518401_ChIP-PET_MESCs_Mouse1.24211295
74KDM2B_26808549_Chip-Seq_DND41_Human1.23833408
75* UBF1/2_26484160_Chip-Seq_HMECs_Human1.23744985
76SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23027591
77NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.22533776
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21052267
79* RUNX1_27514584_Chip-Seq_MCF-7_Human1.20184992
80TP53_18474530_ChIP-ChIP_U2OS_Human1.19634552
81CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19353331
82ERG_21242973_ChIP-ChIP_JURKAT_Human1.17933703
83* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.17683983
84MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.17681942
85* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17173860
86TBX20_22080862_ChIP-Seq_HEART_Mouse1.17138808
87TBX20_22328084_ChIP-Seq_HEART_Mouse1.17138808
88* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.16396038
89TP53_20018659_ChIP-ChIP_R1E_Mouse1.16293332
90NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.14243072
91AR_21909140_ChIP-Seq_LNCAP_Human1.13469025
92SOX2_18692474_ChIP-Seq_MEFs_Mouse1.13445073
93* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.12836892
94NANOG_18692474_ChIP-Seq_MEFs_Mouse1.11712931
95* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.10641007
96* TP53_23651856_ChIP-Seq_MEFs_Mouse1.09583095
97* FOXA2_19822575_ChIP-Seq_HepG2_Human1.08461930
98* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08230824
99CDX2_20551321_ChIP-Seq_CACO-2_Human1.08200646
100* RING1B_27294783_Chip-Seq_NPCs_Mouse1.07929784
101SOX2_20726797_ChIP-Seq_SW620_Human1.07022510
102POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.06910947
103CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06457695
104WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04698857
105TP53_22127205_ChIP-Seq_IMR90_Human1.04408430
106UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03502340
107* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03325845
108MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03318835
109SALL1_21062744_ChIP-ChIP_HESCs_Human1.03237249
110* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.02828453
111TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02803971
112KLF5_25053715_ChIP-Seq_YYC3_Human1.02677466
113* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01409630
114CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00603254
115TP53_16413492_ChIP-PET_HCT116_Human1.00466086
116STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00263080
117SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00248360
118RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99404110
119LXR_22292898_ChIP-Seq_THP-1_Human0.98887078
120ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98623108
121KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98303421
122NANOG_18692474_ChIP-Seq_MESCs_Mouse0.97583316
123NANOG_21062744_ChIP-ChIP_HESCs_Human0.97362929
124KDM2B_26808549_Chip-Seq_JURKAT_Human0.97003827
125ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96927862
126* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96387379
127ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95496021
128PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94881981
129SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.94787539
130RXR_22158963_ChIP-Seq_LIVER_Mouse0.93570235
131MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.93197411
132NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93196046

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005623_abnormal_meninges_morphology3.61847142
2MP0003705_abnormal_hypodermis_morpholog3.16625323
3MP0004272_abnormal_basement_membrane2.91301952
4MP0008438_abnormal_cutaneous_collagen2.72305496
5MP0000537_abnormal_urethra_morphology2.65617851
6MP0003941_abnormal_skin_development2.62713268
7MP0010234_abnormal_vibrissa_follicle2.43835659
8MP0005257_abnormal_intraocular_pressure2.37975578
9MP0010352_gastrointestinal_tract_polyps2.30738947
10MP0001348_abnormal_lacrimal_gland2.07414267
11MP0002877_abnormal_melanocyte_morpholog2.01978824
12MP0003566_abnormal_cell_adhesion2.01397653
13MP0005076_abnormal_cell_differentiation1.95618724
14MP0003091_abnormal_cell_migration1.92749152
15MP0003283_abnormal_digestive_organ1.86208779
16MP0010030_abnormal_orbit_morphology1.82149579
17MP0004858_abnormal_nervous_system1.81140999
18MP0004185_abnormal_adipocyte_glucose1.80293844
19MP0003950_abnormal_plasma_membrane1.80122147
20MP0000534_abnormal_ureter_morphology1.79441492
21MP0005275_abnormal_skin_tensile1.78106827
22MP0003385_abnormal_body_wall1.77448595
23MP0003119_abnormal_digestive_system1.76165385
24MP0000733_abnormal_muscle_development1.71758707
25MP0000516_abnormal_urinary_system1.71302977
26MP0005367_renal/urinary_system_phenotyp1.71302977
27MP0002653_abnormal_ependyma_morphology1.64276761
28MP0002282_abnormal_trachea_morphology1.64019269
29MP0009780_abnormal_chondrocyte_physiolo1.55383092
30MP0001299_abnormal_eye_distance/1.54739727
31MP0004084_abnormal_cardiac_muscle1.54726597
32MP0003942_abnormal_urinary_system1.51199047
33MP0000428_abnormal_craniofacial_morphol1.48955416
34MP0005409_darkened_coat_color1.48466914
35MP0002060_abnormal_skin_morphology1.46924557
36MP0001958_emphysema1.42440852
37MP0002254_reproductive_system_inflammat1.41533390
38MP0000013_abnormal_adipose_tissue1.41209922
39MP0003937_abnormal_limbs/digits/tail_de1.38419555
40MP0000566_synostosis1.36161401
41MP0009053_abnormal_anal_canal1.34861660
42MP0002084_abnormal_developmental_patter1.34802877
43MP0001849_ear_inflammation1.31092686
44MP0003115_abnormal_respiratory_system1.30456761
45MP0000762_abnormal_tongue_morphology1.30280584
46MP0002089_abnormal_postnatal_growth/wei1.27493989
47MP0005197_abnormal_uvea_morphology1.27005771
48MP0003123_paternal_imprinting1.25673528
49MP0000467_abnormal_esophagus_morphology1.24970110
50MP0000750_abnormal_muscle_regeneration1.22805906
51MP0002697_abnormal_eye_size1.22295856
52MP0004133_heterotaxia1.21925078
53MP0002085_abnormal_embryonic_tissue1.20202227
54MP0001915_intracranial_hemorrhage1.17794662
55MP0003935_abnormal_craniofacial_develop1.17035251
56MP0000462_abnormal_digestive_system1.15992199
57MP0004197_abnormal_fetal_growth/weight/1.15269890
58MP0000751_myopathy1.14216206
59MP0000767_abnormal_smooth_muscle1.13918851
60MP0009384_cardiac_valve_regurgitation1.13175672
61MP0000432_abnormal_head_morphology1.12865354
62MP0002896_abnormal_bone_mineralization1.11001276
63MP0001542_abnormal_bone_strength1.10141838
64MP0001730_embryonic_growth_arrest1.09830468
65MP0005508_abnormal_skeleton_morphology1.09753479
66MP0002925_abnormal_cardiovascular_devel1.09687031
67MP0001293_anophthalmia1.08669168
68MP0002234_abnormal_pharynx_morphology1.07644457
69MP0000003_abnormal_adipose_tissue1.07015154
70MP0002108_abnormal_muscle_morphology1.06952426
71MP0009250_abnormal_appendicular_skeleto1.06767704
72MP0003755_abnormal_palate_morphology1.06464947
73MP0005171_absent_coat_pigmentation1.06230826
74MP0002233_abnormal_nose_morphology1.05942909
75MP0005375_adipose_tissue_phenotype1.03961469
76MP0005666_abnormal_adipose_tissue1.02259495
77MP0005503_abnormal_tendon_morphology1.01916931
78MP0002111_abnormal_tail_morphology1.01747737
79MP0001879_abnormal_lymphatic_vessel1.01256853
80MP0003984_embryonic_growth_retardation1.00271564
81MP0002116_abnormal_craniofacial_bone0.99928746
82MP0002088_abnormal_embryonic_growth/wei0.99896544
83MP0001672_abnormal_embryogenesis/_devel0.99162692
84MP0005380_embryogenesis_phenotype0.99162692
85MP0002138_abnormal_hepatobiliary_system0.98565979
86MP0001346_abnormal_lacrimal_gland0.97830826
87MP0003122_maternal_imprinting0.97470248
88MP0001697_abnormal_embryo_size0.96768722
89MP0003279_aneurysm0.93821168
90MP0000778_abnormal_nervous_system0.93103577
91MP0002086_abnormal_extraembryonic_tissu0.92489009
92MP0002295_abnormal_pulmonary_circulatio0.92379682
93MP0000579_abnormal_nail_morphology0.92354172
94MP0002932_abnormal_joint_morphology0.90772967
95MP0003890_abnormal_embryonic-extraembry0.90713520
96MP0003861_abnormal_nervous_system0.90136669
97MP0010368_abnormal_lymphatic_system0.89855134
98MP0002249_abnormal_larynx_morphology0.88836333
99MP0006138_congestive_heart_failure0.87503110
100MP0000049_abnormal_middle_ear0.87050460
101MP0002092_abnormal_eye_morphology0.86411525
102MP0000350_abnormal_cell_proliferation0.85966029
103MP0004134_abnormal_chest_morphology0.84470090
104MP0006054_spinal_hemorrhage0.84309195
105MP0004087_abnormal_muscle_fiber0.83797620
106MP0004233_abnormal_muscle_weight0.83662324
107MP0005595_abnormal_vascular_smooth0.82023217
108MP0001243_abnormal_dermal_layer0.81826576
109MP0005193_abnormal_anterior_eye0.81771418
110MP0005023_abnormal_wound_healing0.81713432
111MP0000163_abnormal_cartilage_morphology0.81195302
112MP0010678_abnormal_skin_adnexa0.81036499
113MP0005248_abnormal_Harderian_gland0.80953970
114MP0001286_abnormal_eye_development0.80213784
115MP0009278_abnormal_bone_marrow0.79658669
116MP0010630_abnormal_cardiac_muscle0.78285393
117MP0003868_abnormal_feces_composition0.76239007
118MP0002128_abnormal_blood_circulation0.75871005
119MP0001614_abnormal_blood_vessel0.75560800
120MP0002114_abnormal_axial_skeleton0.74186281
121MP0002938_white_spotting0.70703568
122MP0001340_abnormal_eyelid_morphology0.69740739
123MP0003315_abnormal_perineum_morphology0.68166675
124MP0005501_abnormal_skin_physiology0.68128264
125MP0008932_abnormal_embryonic_tissue0.66652597
126MP0005408_hypopigmentation0.65489288
127MP0003453_abnormal_keratinocyte_physiol0.63297583
128MP0002113_abnormal_skeleton_development0.62770094
129MP0002177_abnormal_outer_ear0.61562619

Predicted human phenotypes

RankGene SetZ-score
1Vascular tortuosity (HP:0004948)4.01652581
2Arterial tortuosity (HP:0005116)3.92214239
3Premature rupture of membranes (HP:0001788)3.52514140
4Protrusio acetabuli (HP:0003179)3.46672354
5Shallow orbits (HP:0000586)3.42265736
6Ulnar bowing (HP:0003031)2.87755600
7Atrophic scars (HP:0001075)2.85706941
8Ankle contracture (HP:0006466)2.83294151
9Cerebral aneurysm (HP:0004944)2.76294980
10Vertebral compression fractures (HP:0002953)2.65810363
11Follicular hyperkeratosis (HP:0007502)2.59206470
12Scapular winging (HP:0003691)2.49681500
13Missing ribs (HP:0000921)2.47835421
14Hyperacusis (HP:0010780)2.46819457
15Short nail (HP:0001799)2.43896227
16Abnormality of the acetabulum (HP:0003170)2.35527215
17Deep venous thrombosis (HP:0002625)2.34067143
18Biconcave vertebral bodies (HP:0004586)2.31312209
19Mitral regurgitation (HP:0001653)2.30204486
20Colon cancer (HP:0003003)2.26579587
21Adactyly (HP:0009776)2.23485064
22Bladder diverticulum (HP:0000015)2.23150706
23Wide anterior fontanel (HP:0000260)2.18336351
24Abnormality of dentin (HP:0010299)2.17595413
25Joint laxity (HP:0001388)2.17049878
26Increased connective tissue (HP:0009025)2.16239314
27Abnormal ossification of hand bones (HP:0005921)2.15936971
28Upper limb amyotrophy (HP:0009129)2.15926828
29Distal upper limb amyotrophy (HP:0007149)2.15926828
30Mitral stenosis (HP:0001718)2.15467174
31Genu recurvatum (HP:0002816)2.14560636
32Abnormality of carpal bone ossification (HP:0006257)2.14299246
33Right ventricular cardiomyopathy (HP:0011663)2.12487735
34Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.12358952
35Short 4th metacarpal (HP:0010044)2.12358952
36Hand muscle atrophy (HP:0009130)2.09766534
37Elbow flexion contracture (HP:0002987)2.08369896
38Natal tooth (HP:0000695)2.07535074
39Bronchomalacia (HP:0002780)2.06398068
40Disproportionate tall stature (HP:0001519)2.06393903
41Cortical dysplasia (HP:0002539)2.06344878
42Type 1 muscle fiber predominance (HP:0003803)2.05476071
43Vertebral arch anomaly (HP:0008438)2.02944612
44Mildly elevated creatine phosphokinase (HP:0008180)2.02712825
45Rectal prolapse (HP:0002035)2.02558605
46Cardiovascular calcification (HP:0011915)2.01442973
47Abnormality of the astrocytes (HP:0100707)2.00515815
48Astrocytoma (HP:0009592)2.00515815
49Aplasia of the phalanges of the hand (HP:0009802)2.00095828
50Aplasia involving bones of the extremities (HP:0009825)2.00095828
51Aplasia involving bones of the upper limbs (HP:0009823)2.00095828
52Flat acetabular roof (HP:0003180)1.99773125
53Arnold-Chiari malformation (HP:0002308)1.99650217
54Broad face (HP:0000283)1.98612938
55Abnormal delivery (HP:0001787)1.98018735
56Buphthalmos (HP:0000557)1.97663641
57Shawl scrotum (HP:0000049)1.97611822
58Aortic dissection (HP:0002647)1.97551069
59Camptodactyly of toe (HP:0001836)1.97329986
60Lymphangioma (HP:0100764)1.96460522
61Abnormality of the 4th metacarpal (HP:0010012)1.95475769
62Aortic regurgitation (HP:0001659)1.94793705
63Spinal rigidity (HP:0003306)1.94205258
64Asymmetry of the thorax (HP:0001555)1.92862159
65Esophageal atresia (HP:0002032)1.92681789
66Ependymoma (HP:0002888)1.91622042
67Deviation of the thumb (HP:0009603)1.91468970
68Difficulty climbing stairs (HP:0003551)1.91018255
69Long toe (HP:0010511)1.90718604
70Hypoventilation (HP:0002791)1.90434122
71Hyperextensible skin (HP:0000974)1.90208421
72Partial duplication of the phalanx of hand (HP:0009999)1.88456232
73Skull defect (HP:0001362)1.88250028
74Vertebral hypoplasia (HP:0008417)1.87909976
75Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.87909976
76Renal duplication (HP:0000075)1.87675788
77Morphological abnormality of the middle ear (HP:0008609)1.87634498
78Aneurysm (HP:0002617)1.87630126
79Aortic aneurysm (HP:0004942)1.87527710
80Mitral valve prolapse (HP:0001634)1.86218046
81Neoplasm of the oral cavity (HP:0100649)1.85149264
82Milia (HP:0001056)1.84302035
83Muscle fiber splitting (HP:0003555)1.84112734
84Partial duplication of thumb phalanx (HP:0009944)1.82846673
85Osteolytic defects of the hand bones (HP:0009699)1.82319605
86Osteolytic defects of the phalanges of the hand (HP:0009771)1.82319605
87Achilles tendon contracture (HP:0001771)1.82259559
88Broad metatarsal (HP:0001783)1.81515745
89Spondylolisthesis (HP:0003302)1.81420197
90Dilatation of the ascending aorta (HP:0005111)1.81291199
91Neonatal short-limb short stature (HP:0008921)1.81222895
92Soft skin (HP:0000977)1.80923957
93Selective tooth agenesis (HP:0001592)1.80371429
94Hypoplasia of the iris (HP:0007676)1.79416322
95Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.79306594
96Short humerus (HP:0005792)1.78839651
97Hallux valgus (HP:0001822)1.78723724
98Trismus (HP:0000211)1.78598245
99Fibroma (HP:0010614)1.78051077
100Broad ribs (HP:0000885)1.77819156
101Fused cervical vertebrae (HP:0002949)1.77776361
102Bowed forearm bones (HP:0003956)1.77633302
103Bowing of the arm (HP:0006488)1.77633302
104Anophthalmia (HP:0000528)1.77001789
105Fragile skin (HP:0001030)1.76998505
106Gastrointestinal carcinoma (HP:0002672)1.76486060
107Malignant gastrointestinal tract tumors (HP:0006749)1.76486060
108Abnormality of the Achilles tendon (HP:0005109)1.75088698
109Coxa vara (HP:0002812)1.74841127
110Absent frontal sinuses (HP:0002688)1.74473241
111Absent toe (HP:0010760)1.74274101
112Syringomyelia (HP:0003396)1.74243401
113Spinal cord lesions (HP:0100561)1.74243401
114Down-sloping shoulders (HP:0200021)1.74081929
115Turricephaly (HP:0000262)1.73881509
116Chin dimple (HP:0010751)1.72724056
117Bowel diverticulosis (HP:0005222)1.72296855
118Peritonitis (HP:0002586)1.72256295
119Proximal placement of thumb (HP:0009623)1.72229020
120Hyporeflexia of lower limbs (HP:0002600)1.71762944
121Congenital glaucoma (HP:0001087)1.71492285
122Abnormal hand bone ossification (HP:0010660)1.71374880
123Protruding ear (HP:0000411)1.70628607
124Esophageal varix (HP:0002040)1.70533576
125Fibrous tissue neoplasm (HP:0012316)1.70265586
126Wrist flexion contracture (HP:0001239)1.70091134
127Abnormality of the distal phalanges of the toes (HP:0010182)1.69877551
128Back pain (HP:0003418)1.68881906
129Absent hand (HP:0004050)1.68046508
130Hematochezia (HP:0002573)1.67264949
131Wormian bones (HP:0002645)1.67233161
132Insomnia (HP:0100785)1.67056672
133Advanced eruption of teeth (HP:0006288)1.66399266
134Aplasia/hypoplasia of the humerus (HP:0006507)1.66179834
135Blue sclerae (HP:0000592)1.65458334
136Renovascular hypertension (HP:0100817)1.64669181
137Deep palmar crease (HP:0006191)1.64039876
138Hypoplastic ischia (HP:0003175)1.64030676
139Coronal craniosynostosis (HP:0004440)1.64005232
140Arachnodactyly (HP:0001166)1.63763412
141Focal segmental glomerulosclerosis (HP:0000097)1.63596933
142Cervical subluxation (HP:0003308)1.63345662
143Increased variability in muscle fiber diameter (HP:0003557)1.63108199
144Neoplasm of the heart (HP:0100544)1.62462526
145Broad thumb (HP:0011304)1.62090043
146Inguinal hernia (HP:0000023)1.61510239
147Overgrowth (HP:0001548)1.61370191
148Vertebral fusion (HP:0002948)1.61207975
149Subacute progressive viral hepatitis (HP:0006572)1.61082462
150Vertebral clefting (HP:0008428)1.60477642
151Deviation of the hallux (HP:0010051)1.60467827
152Abnormal vertebral ossification (HP:0100569)1.60407813
153Ectopia lentis (HP:0001083)1.59352664
154Midface retrusion (HP:0011800)1.59111623
155Delayed cranial suture closure (HP:0000270)1.58376037
156Pterygium (HP:0001059)1.58345973
157Abnormality of the shoulder girdle musculature (HP:0001435)1.57679493
158Increased density of long bones (HP:0006392)1.57242088
159Abnormality of the distal phalanx of the thumb (HP:0009617)1.57129799
160Ankyloglossia (HP:0010296)1.56957284
161Intestinal polyp (HP:0005266)1.56952169

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TYRO34.39451252
2EPHA23.29311725
3PDGFRA3.02165872
4LATS12.67013209
5TRIB32.63162103
6TTN2.43707607
7PTK62.40623872
8MYLK2.36851131
9DDR22.32420371
10PTK22.22515416
11PDGFRB2.12434650
12LATS22.02293075
13MST1R2.01395555
14SIK11.97676362
15FER1.94755046
16PAK41.92398465
17EPHB21.89750694
18BMX1.78700758
19PKN21.78454812
20RIPK11.72825823
21TESK11.69152517
22MAP3K21.65313657
23FGFR41.61108751
24LIMK11.60387517
25EPHB11.59293828
26CDK121.56476509
27PAK31.48587109
28ICK1.47916099
29NEK91.46814963
30DMPK1.45357508
31FES1.35904809
32KSR21.35580716
33PAK21.33409664
34MET1.30263711
35SMG11.28727406
36MTOR1.27697455
37AKT31.27401550
38LRRK21.25585870
39ROCK11.23706716
40EEF2K1.18543526
41NTRK11.15586045
42WNK41.14168307
43STK381.14101123
44FLT31.11032537
45PRKD31.07771612
46RET1.06320881
47TGFBR21.05167770
48MAP2K21.04090994
49STK38L1.00985934
50ILK0.97020555
51KDR0.95601916
52PRKD20.93330854
53CDK80.92079263
54MAP3K100.91354591
55WNK30.90485124
56TGFBR10.87434186
57CHUK0.87273954
58CSK0.86953083
59RPS6KA20.85945868
60FGFR10.85205963
61RPS6KB20.84756712
62EPHA30.83627065
63LMTK20.83365781
64PHKG20.82972640
65PHKG10.82972640
66PBK0.81166889
67PAK60.80713709
68MAPK150.79390394
69SCYL20.77444182
70ROCK20.76897290
71GSK3A0.76628043
72KSR10.76052195
73MAP3K30.75457235
74DYRK1B0.75352026
75ERN10.75277567
76MAP3K80.72869892
77PIK3CA0.72329340
78IRAK30.72233875
79MAP2K10.71206545
80TIE10.68496676
81MOS0.68397955
82ERBB20.67805680
83ALK0.66124229
84NEK20.66090677
85INSR0.65494113
86MAP3K60.64387062
87PIM20.60896502
88MAP3K90.59958137
89PAK10.59192494
90CDC42BPA0.56717194
91BCR0.56598125
92UHMK10.56404371
93CAMK1G0.55311767
94STK30.55067904
95TESK20.54991779
96DYRK20.53533550
97IRAK10.53518222
98CASK0.53487790
99PTK2B0.51523683
100PRKG20.50166598
101PRKCI0.50148464
102AKT20.49471249
103PNCK0.49344983
104PASK0.49066340
105SRC0.46206295
106ABL20.45859283
107TRPM70.45728921
108STK100.42678095
109TTK0.42119028
110MAPKAPK30.41471033
111FGR0.41243549
112NEK10.40219244
113TSSK60.40127573
114WNK10.39663123
115CDK90.38802526
116PKN10.38659687
117CDK150.38205694
118PRKD10.38119054
119BRSK10.37829743
120CDK180.37451319
121PDK20.37309613
122ERBB40.36582760
123CDK70.35852470
124RPS6KA10.35734226
125AURKA0.35666866
126MELK0.35401084
127WEE10.35392560
128CDK11A0.35185243
129PRKAA20.34272611
130ARAF0.33297494
131CAMK2G0.32583516
132DAPK30.32139765
133CDK60.31351758
134CHEK10.30645314
135EIF2AK10.30489929
136AURKB0.30271396
137FGFR30.29796306
138CDK140.29671956
139BRD40.28257504
140CAMK2B0.27298783
141RPS6KC10.27274012

Predicted pathways (KEGG)

RankGene SetZ-score
1Adherens junction_Homo sapiens_hsa045202.67404226
2Hippo signaling pathway_Homo sapiens_hsa043902.40106610
3Basal cell carcinoma_Homo sapiens_hsa052172.34817391
4Focal adhesion_Homo sapiens_hsa045102.30520481
5ECM-receptor interaction_Homo sapiens_hsa045122.28030999
6Tight junction_Homo sapiens_hsa045302.11718831
7Hedgehog signaling pathway_Homo sapiens_hsa043402.02152104
8MicroRNAs in cancer_Homo sapiens_hsa052062.00713175
9Small cell lung cancer_Homo sapiens_hsa052221.94995245
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.91542027
11Viral myocarditis_Homo sapiens_hsa054161.87722192
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.86018836
13Proteoglycans in cancer_Homo sapiens_hsa052051.74822420
14Bladder cancer_Homo sapiens_hsa052191.67610147
15Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.64809373
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.62719199
17TGF-beta signaling pathway_Homo sapiens_hsa043501.54028145
18Axon guidance_Homo sapiens_hsa043601.53189470
19Dilated cardiomyopathy_Homo sapiens_hsa054141.52124057
20Renal cell carcinoma_Homo sapiens_hsa052111.50696450
21Endometrial cancer_Homo sapiens_hsa052131.47737063
22Chronic myeloid leukemia_Homo sapiens_hsa052201.47132353
23Complement and coagulation cascades_Homo sapiens_hsa046101.40507229
24Amoebiasis_Homo sapiens_hsa051461.39485328
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.36311268
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.35505322
27Glioma_Homo sapiens_hsa052141.34528085
28Prion diseases_Homo sapiens_hsa050201.34349435
29AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.32282932
30Melanoma_Homo sapiens_hsa052181.32031736
31Notch signaling pathway_Homo sapiens_hsa043301.27659797
32Colorectal cancer_Homo sapiens_hsa052101.26539553
33Estrogen signaling pathway_Homo sapiens_hsa049151.23189666
34Regulation of actin cytoskeleton_Homo sapiens_hsa048101.22923116
35Melanogenesis_Homo sapiens_hsa049161.21456476
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20565744
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.18889265
38Pathways in cancer_Homo sapiens_hsa052001.17241992
39Prostate cancer_Homo sapiens_hsa052151.17218575
40Central carbon metabolism in cancer_Homo sapiens_hsa052301.16985204
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.16491889
42Wnt signaling pathway_Homo sapiens_hsa043101.14780355
43Protein digestion and absorption_Homo sapiens_hsa049741.14399235
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09587208
45mTOR signaling pathway_Homo sapiens_hsa041501.08526320
46Dorso-ventral axis formation_Homo sapiens_hsa043201.08478210
47Biosynthesis of amino acids_Homo sapiens_hsa012301.08352232
48Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06758264
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05606650
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04776392
51Pancreatic cancer_Homo sapiens_hsa052121.04773051
52Gap junction_Homo sapiens_hsa045401.04435559
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04175534
54Lysine degradation_Homo sapiens_hsa003100.99246710
55PI3K-Akt signaling pathway_Homo sapiens_hsa041510.97163763
56Rap1 signaling pathway_Homo sapiens_hsa040150.94407258
57p53 signaling pathway_Homo sapiens_hsa041150.93052685
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91741923
59VEGF signaling pathway_Homo sapiens_hsa043700.91107032
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90888844
61Galactose metabolism_Homo sapiens_hsa000520.90209907
62N-Glycan biosynthesis_Homo sapiens_hsa005100.88452530
63Thyroid cancer_Homo sapiens_hsa052160.88364105
64ErbB signaling pathway_Homo sapiens_hsa040120.88355533
65Vitamin B6 metabolism_Homo sapiens_hsa007500.88305779
66Steroid biosynthesis_Homo sapiens_hsa001000.87974345
67Prolactin signaling pathway_Homo sapiens_hsa049170.86550567
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84400786
69HTLV-I infection_Homo sapiens_hsa051660.82865467
70Toxoplasmosis_Homo sapiens_hsa051450.81736153
71Type II diabetes mellitus_Homo sapiens_hsa049300.81431026
72HIF-1 signaling pathway_Homo sapiens_hsa040660.80634168
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79980372
74Insulin resistance_Homo sapiens_hsa049310.79922069
75GnRH signaling pathway_Homo sapiens_hsa049120.77991444
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.77972339
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77942384
78Viral carcinogenesis_Homo sapiens_hsa052030.77051894
79Shigellosis_Homo sapiens_hsa051310.77011946
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.75439724
81AMPK signaling pathway_Homo sapiens_hsa041520.75209797
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75169507
83Choline metabolism in cancer_Homo sapiens_hsa052310.73374811
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72876569
85Pentose phosphate pathway_Homo sapiens_hsa000300.72433298
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71462502
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69863281
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69712758
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69150201
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68081141
91TNF signaling pathway_Homo sapiens_hsa046680.67592346
92Thyroid hormone synthesis_Homo sapiens_hsa049180.66443627
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66402091
94Cholinergic synapse_Homo sapiens_hsa047250.65933178
95Apoptosis_Homo sapiens_hsa042100.65874441
96mRNA surveillance pathway_Homo sapiens_hsa030150.65014197
97Bile secretion_Homo sapiens_hsa049760.64717056
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64195860
99Platelet activation_Homo sapiens_hsa046110.62591189
100Non-small cell lung cancer_Homo sapiens_hsa052230.62369627
101Acute myeloid leukemia_Homo sapiens_hsa052210.62221548
102RNA transport_Homo sapiens_hsa030130.61177183
103Endocytosis_Homo sapiens_hsa041440.60909687
104Insulin signaling pathway_Homo sapiens_hsa049100.60726617
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.59683263
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59313405
107Arginine biosynthesis_Homo sapiens_hsa002200.57888024
108Phenylalanine metabolism_Homo sapiens_hsa003600.57193323
109Vibrio cholerae infection_Homo sapiens_hsa051100.56613965
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.56611978
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55053946
112Oocyte meiosis_Homo sapiens_hsa041140.54475900
113Ras signaling pathway_Homo sapiens_hsa040140.53827592
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53370782
115Arginine and proline metabolism_Homo sapiens_hsa003300.52876252
116Oxytocin signaling pathway_Homo sapiens_hsa049210.51647756
117Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51437373
118Carbon metabolism_Homo sapiens_hsa012000.51402664
119Spliceosome_Homo sapiens_hsa030400.50386103
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.49843694
121FoxO signaling pathway_Homo sapiens_hsa040680.49810256
122Fructose and mannose metabolism_Homo sapiens_hsa000510.49229407
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49060203
124Cell cycle_Homo sapiens_hsa041100.48900800
125Fatty acid biosynthesis_Homo sapiens_hsa000610.47808659
126Tyrosine metabolism_Homo sapiens_hsa003500.46721665
127Sphingolipid metabolism_Homo sapiens_hsa006000.46152871
128Glucagon signaling pathway_Homo sapiens_hsa049220.46001389
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45454493
130PPAR signaling pathway_Homo sapiens_hsa033200.44836330
131Cyanoamino acid metabolism_Homo sapiens_hsa004600.40539185
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40455015
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40121222
134Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38897023
135Fat digestion and absorption_Homo sapiens_hsa049750.38560077

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